Gliclazide (Gliclazide)

Gliclazide MV bụ ihe nnọchianya hypoglycemic maka ịgwọ ụdị ọrịa shuga 2. Ihe na-arụ ọrụ bụ Gliclazide.

Ngwunye ọgwụ hypoglycemic nke na-ahụ maka ọnya, ihe dị na usoro nke usoro nke n'ọgbọ nke abụọ. Na-akwalite mmiri ọgwụ insulin site na mkpụrụ ndụ nke akwara.

Ọgwụ ahụ na-eme ka anụ ahụ dị elu na insulin, na-akpali ọrụ nke enzymes intracellular (karịchaa, akwara glycogen synthetase). Na-ebelata oge dị n'etiti oge iri nri rue mmalite insulin insulin. Weghachi mbido insulin nke mbụ, na-ebelata oke postprandial nke hyperglycemia.

Gliclazide MV na-ebelata nrapado platelet na nchịkọta, na-ebelata mmepe nke thrombus parietal, ma na-eme ka akwara fibrinolytic vaskụla. Normalizes vaskụla permeability.

• Lowers cholesterol ọbara (Cs) na Cs-LDL
• Na-abawanye ịta nke HDL-C,
• Na-ebelata radicals n'efu.
• Na-egbochi mmepe nke microthrombosis na atherosclerosis.
• Ọ na - eme ka microcirculation dịkwuo mma.
• Na-ebelata akwara vaskụla na adrenaline.

Site na nephropathy ọrịa mamịrị na iji ogologo oge, enwere nnukwu mbelata na proteinuria.

Mgbe ị na-ede ọgwụ ahụ, njikwa glycemic siri ike nwere uru dị ukwuu nke anaghị ekpebi site na nsonaazụ nke iji ọgwụ ọgwụ antihypertensive.

Nchikota nke Gliclazide MV (mbadamba 1):

• Ihe na-arụ ọrụ: gliclazide - 30 ma ọ bụ 60 mg,
• Ihe ntinye aka: hypromellose - 70 mg, sillofon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Ihe ngosi maka ojiji

Kedu ihe na-enyere Gliclazide MV aka? Dịka ntuziaka ahụ si dị, ọgwụ maka ọgwụgwọ nke ogo ogo 2 nke ọrịa shuga mellitus (nke na-abụghị insulin) na ngosipụta izizi nke microangiopathy mamịrị.

A na-ejikwa ya maka igbochi nsogbu microcirculatory, dị ka akụkụ nke usoro ọgwụgwọ siri ike, n'otu oge yana usoro ndị ọzọ na-enye sulfonylurea.

Ntụziaka maka iji Gliclazide MV (30 60 mg), usoro onunu ogwu

Ọgwụ a na -eche ọnụ na 30 nkeji tupu nri.

Ntuziaka a na-atụ aro kwa ụbọchị nke Gliclazide MV bụ 80 mg site na ntuziaka maka ojiji; ọ bụrụ na ọ dị mkpa, ọ na-abawanye ruo 160-320 mg na usoro abụọ kewara.

Na -eche iche na-adabere na-ebu ọnụ glycemia na 2 awa mgbe eri, yana na clinical ngosipụta nke ọrịa.

Ọ bụrụ n’ịfughị ​​ogwu, ị gaghị a takeụ okpukpu abụọ. Mgbe ị na-edochi ọgwụ hypoglycemic ọzọ, a gaghị achọ oge mgbanwe - Gliclazide MB na-amalite ịchi ya.

Ikekwe ngwakọta na biguanides, insulin, alfa-glucosidase inhibitors. Na mmezi obere akwara na-agabigaghị agbatị, a na-ede ya otu usoro onunu ogwu.

N'ime ndị ọrịa nwere ọrịa hypoglycemia, a na-eji ntakịrị ọgwụ.

Ntụziaka pụrụ iche

Na ọgwụgwọ nke ọrịa mellitus na-abụghị insulin na-akpata, a ga-eji ọgwụ ahụ n'otu oge yana nri nwere obere kalori nwere obere carbohydrates.

N'oge usoro ọgwụgwọ, ịkwesịrị ileba anya n'ihe ọmụmụ kwa ụbọchị na ọkwa glucose, yana ọkwa glucose n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri.

Nsonaazụ

Ntụziaka ahụ dọrọ aka ná ntị na ọ ga-ekwe omume ịzụlite mmetụta ndị a na-esote mgbe ị na-ede akwụkwọ Gliclazide MV:

• Ogbugbu, vomiting, afo mgbu,
• Thrombocytopenia, erythropenia, agranulocytosis, hemolytic anaemia,
• Allergic vasculitis,
• Akpụkpọ ahụ, itching,
• Imeju imeju
• Ahụhụ anya
• Hypoglycemia (ya na ngafere oke).

Ihe ngbanwe

Glyclazide MV na-contraindicated na ndị a:

• 1dị 1 nke ọrịa shuga mellitus (insulin-dependance),
• Ketoacidosis
• Ọrịa mamịrị precca na coma
• Nsogbu akụrụ na oke ịba ọcha n'anya,
• Hypersensitivity na sulfonylureas na sulfonamides.
• Ojiji nke gliclazide na imerizole imerizole (gụnyere miconazole).

Edebere ya site na iji nlezianya mee agadi, na-enwe nri na-adịghị adị, hypothyroidism, hypopituitarism, ọrịa akwara siri ike na atherosclerosis, enweghi afọ ojuju, ọgwụgwọ ogologo oge na glucocorticosteroids.

Dodoụbiga ya ókè

A na - egosipụta nrịbama nke overdose site na hypoglycemia - isi ọwụwa, ike ọgwụgwụ, adịghị ike siri ike, ịsụsọ, palpitations, ọbara mgbali elu, arrhythmia, iro ụra, mkpasu iwe, iwe, iwe iwe, mmeghachi omume oge, ọhụhụ ụzọ na okwu, ịma jijiji, ọgbụgba, ihe mgbu, bradycardia, nsụhọ nke mmụọ.

Site na hypoglycemia dị ala na-enweghị mmetụ ọfụma, belata ọgwụ ahụ ma ọ bụ nwekwuo carbohydrates na-enye nri.

Ọ bụrụ na enyocha hypoglycemic coma ma ọ bụ enyo enyo enyo, 50 ml nke 40% glulin ngwọta (dextrose) kwesịrị ịbanye (intravenously). Mgbe nke ahụ gasị, a ga - etinye ntụtụ 5% dextrose n'ime intravenly, nke ga - enyere gị aka ịchekwa mkpa glucose dị n'ọbara (ọ bụ ihe dịka 1 g / l).

Ekwesịrị iji nlezianya nyochaa ọbara glucose na onye ọrịa ahụ ka ọ na-elele onye ọrịa ahụ ọ dịkarịa ala ụbọchị 2 mgbe ọ nwesịrị ịdoụbiga mmanya ókè.

Ọnọdụ ya kpebisikwuo ike mkpa nyocha nke ọrụ dị mkpa nke onye ọrịa.

Ebe ọ bụ na ihe na-arụ ọrụ dị ukwuu na-ejikọ protein protein plasma, usoro ọgwụgwọ adịghị arụ ọrụ.

Analogs Glyclazide MV, ọnụahịa dị na ahịa ọgwụ

Ọ bụrụ na ọ dị mkpa, ịnwere ike dochie Gliclazide MV site na iji analog na mmetụta ọgwụgwọ - ndị a bụ ọgwụ ọjọọ:

Mgbe ị na-ahọrọ analogues, ọ dị mkpa ịghọta na ntuziaka maka ojiji nke Glyclazide MV, ọnụahịa na nyocha, anaghị etinye ọgwụ maka otu ụdị mmetụta. Ọ dị mkpa ịnweta ndụmọdụ nke dọkịta na ịghara ime mgbanwe ọgwụ ọ bụla.

Ọnụahịa na ụlọ ahịa ọgwụ Russia: Glyclazide MV 30 mg 60 mbadamba 60 - site na 123 ruo 198 rubles, mbadamba Glyclazide MV 60 mg 30 - site na 151 ruo 210 rubles, dị ka ọgwụ ọgwụ 471.

Chekwaa n'ebe gbara ọchịchịrị, ebe ụmụaka agaghị enweta ya na okpomọkụ ruo 25 Celsius. Ndụ shelf bụ afọ 3.

Ọgwụ Farmacology

Na-eme ka mmiri ọgwụ insulin na-abawanye site na mkpụrụ ndụ beta nke pancreatic ma melite itinye glucose. Na-akpali ọrụ nke akwara glycogen synthetase. Irè na metabolic latent latent mellitus, na ndị ọrịa nwere oke ibu usoro iwu. Na-ebuputa profaịlụ glycemic mgbe ọtụtụ ụbọchị ọgwụgwọ gasịrị. Ọ na - ewelata oge dị n’etiti oge iri nri na mmalite insulin insulin, na - eweghachi mbido insulin mbụ ma belata hyperglycemia nke iri nri. Ọ na - eme ka ọgwụ mgbochi ala dị mma, akụrụngwa nke ọrịa rheological, ọbara ọbara na usoro microcirculation. Na-egbochi mmepe nke microvasculitis, gụnyere ọnya anya nke anya. Na-egbochi nchịkọta platelet, na-eme ka nrụpụta nkekọ dịkwuo ntakịrị, na-eme ka heparin na ọrụ fibrinolytic dịkwuo elu, na-eme ka ndidi heparin nwekwuo ike. Ọ na-egosipụta akụrụngwa antioxidant, na-eme ka vasculari na-emekọ njikọ, na-eme ka ọbara na-aga n'ihu na microvessels, na-ewepụ ihe ịrịba ama nke microstasis. Site na nephropathy mamịrị, a na-ebelata proteinuria.

Na nyocha na ọmụmụ banyere egbu egbu na ụdị egbu egbu, enweghị akara nke ọrịa carcinogenicity, mutagenicity na teratogenicity (oke, oke bekee), yana mmetụta na ọmụmụ (oke).

Jiri nwayọ na ngwa ngwa mụta na ngịga diges, C_max rụzuru mgbe awa 2-6 gasịrị (maka mbadamba nkume nwere ntọhapụ gbanwere - awa 6-12) gachara. Emebere ndọta plasma ịkpa oke mgbe ụbọchị abụọ gachara. Indmịnye protein ndị dị na plasma bụ 85–9%, olu nke nkesa bụ 13-24 l. Ogologo oge iji mee ihe n’otu ọgwụ ruru awa iri abụọ na anọ (maka mbadamba ụrọ nke ewepụtara ahapụrụ - karịa awa iri abụọ na anọ). N'ime imeju, ọ na - eme ntụ ntụ, hydroxylation, glucuronidation na usoro nke metabolites 8 na - adịghị arụ ọrụ, otu n'ime ha nwere mmetụta microcirculation. A na - ekeji ya n'ụdị metabolites na mmamịrị (65%) na site na nri diges (12%). Ndi_1/2 - 8-12 awa (maka mbadamba nkume nwere ntọhapụ gbanwere - ihe dị ka awa iri na isii).

Nsonaazụ nke ihe ahụ Glyclazide

Site na ngwara: ọ na - adịkarịke - mgbaàmà nke dyspeptik (ọgbụgbọ, ọgbụgbọ, mgbu nke afọ), adịkarịghị - jaundice.

Site na sisitemu obi na obara: cytopenia atụgharị, eosinophilia, anaemia.

Na akpukpo ahu: adịkarịghị - mmeghachi omume nfụkasị anụ ahụ, eserese.

Site n'akụkụ nke metabolism: hypoglycemia.

Site na ụjọ na akwara anụ ahụ: adịghị ike, isi ọwụwa, ọgbụgbọ, mgbanwe nke uto.

Mmekorita

Mmetụta na-abawanye nke Ace inhibitors, anabolic Steroid, beta-blockers, fibrates, biguanides, chloramphenicol, cimetidine, coumarin, fenfluramine, fluoxetine, salicylates, guanethidine, Mao inhibitors, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamide, tetracyclines.

Barbiturates, chlorpromazine, glucocorticoids, sympathomimetics, glucagon, saluretics, rifampicin, homonụ thyroid, nnu nke lithium, oke nicotinic acid, ọgwụ mgbochi na estrogens - na-ebelata hypoglycemia.

Dodoụbiga ya ókè

Ọrịa Ọnọdụ hypoglycemic, ruo coma, akụkụ ụbụrụ.

Ọgwụgwọ: ịbanye glucose dị n'ime, ọ bụrụ na ọ dị mkpa - na / ntinye nke usoro glucose (50%, 50 ml). Nyochaa glucose, urea nitrogen, electrolytes serum. Na ụbụrụ ụbụrụ - mannitol (iv), dexamethasone.

Glyclazide-akpachara anya

N'oge usoro ị doseụ ọgwụ, ọkachasị mgbe ejikọtara ya na ọgwụ insulin, ọ dị mkpa iji chọpụta profaịlụ shuga na mgbanwe nke glycemia, n'ọdịniihu a na-ahụ maka ọkwa glucose ọbara n'ọdịniihu. Maka igbochi hypoglycemia, ọ dị mkpa n'ụzọ doro anya na oriri, zere agụụ ma kwụsị ị useụ mmanya. Ojiji nke beta-igbochi egbochi nwere ike ikpuchi ihe ngosi nke hypoglycemia. A na-atụ aro iji obere carb, nke nwere obere carb. Jiri ịkpachara anya na-arụ ọrụ maka ndị ọkwọ ụgbọ ala na ndị ọrụ ha jikọtara na itinye uche ha na nlebara anya.

Mwepụta wepụtara ya na ihe mejupụtara

Gliclazide MV dị n'ụdị mbadamba ụrọ nwere ndọtọ gbanwere: cylindrical, biconvex, ọcha nwere ude ma ọ bụ ọcha, obere marbling ga-ekwe omume (10, 20 ma ọ bụ iberibe iri atọ na ngwakọta aluminium ma ọ bụ ngwugwu mkpụrụ ndụ polyvinyl, 1, 2, 3, Mpempe akwụkwọ 4, 5, 6, 10 na ngwungwu kaadiboodu, 10, 20, 30, 40, 50, 60, ma ọ bụ 100 PC. Na mpempe plastik, 1 nwere ike na kaadiboodu).

Ngwakọta nke mbadamba 1 gụnyere:

• Ihe na-arụ ọrụ: gliclazide - 30 mg,
• Ihe ntinye aka: hypromellose - 70 mg, sillofon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Mlọ ọgwụ

Glyclazide bụ ihe dị n'ụsọ sulfonylurea nke nwere ngwongwo hypoglycemic ma bu n'obi maka nchịkwa ọnụ. Ọdịiche ya site na ọgwụ ọjọọ na ụdị a bụ ọnụnọ nke nwere heterocyclic mgbanaka N-nwere njikọ endocyclic.

Gliclazide na-ebelata glucose ọbara, na-akwalite mmepụta insulin site na mkpụrụ ndụ beta nke agwaetiti Langerhans. Nnukwu ịba ụba nke C-peptide na postprandial insulin na-adịgide ka afọ nke ọgwụgwọ 2 gasịrị. Dị ka ọ dị n'ihe ndị ọzọ sitere na usoro sulfonylurea, mmetụta a bụ n'ihi nzaghachi ike nke β-sel nke agwaetiti nke Langerhans maka mkpali glucose, a na-arụ dị ka ụdị physiological si dị. Ọ bụghị nanị na Gliclazide na-emetụta metabolism metabolism, kamakwa ọ na-akpalite mmetụta hemovascular.

N'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke gelllazide, gliclazide na-enyere aka weghachite mbido mbụ nke mmepụta insulin, nke bụ nsonaazụ nke glucose ma na-akpali usoro nke abụọ nke nzuzo insulin. Nnukwu mmụba na njikọta insulin na-ejikọ ya na nzaghachi maka mkpali kpatara glucose ma ọ bụ oriri nri.

Ojiji nke gliclazide na-ebelata ihe ize ndụ nke imepụta obere akpa arịa ọbara ọbara site na ime ihe ndị nwere ike ịkpalite mmepe nke nsogbu na ndị ọrịa nwere ọrịa mellitus, mbelata ọdịnaya nke ihe na-eme ka platelet (thromboxane B₂, beta-thromboglobulin), ihe mgbochi nke platelet adhesion na nchịkọta, yana imetụta mweghachi nke fibrinolytic sistemu nke vaskụla endothelium, na ụba ọrụ nke plasminogen, nke bụ ihe na-eme ka anụ ahụ rụọ ọrụ.

Ojiji nke glycazide gbanwere, ebumnuche glycosylated hemoglobin (HbAlc) erughị 6.5%, na njikwa glycemic siri ike dabere na ọmụmụ ụlọ ọgwụ a pụrụ ịdabere na ya, nwere ike belata ihe egwu macro- na nsogbu microvaskụ na-eso ụdị ọrịa shuga 2, ma e jiri ya tụnyere glycemic ọdịnala. njikwa.

Mmejuputa ikike ogwu glycemic siri ike mejuputara gliclazide (nkezi kwa ubochi bu 103 mg) na iwelie onodu ya (ihe ruru 120 mg kwa ubochi) mgbe ị na-eme usoro ọgwụgwọ na ndabere (ma ọ bụ kama) tupu ịgbakwunye ya hypoglycemic ọgwụ (dịka ọmụmaatụ, insulin, metformin mkpụrụ osisi thiazolidinedione, alfa glucosidase inhibitor). Ojiji gliclazide na otu ndị ọrịa nọ na-ahụ maka nchịkwa glycemic siri ike (na nkezi, uru HbAlc bụ 6.5% na nkezi oge nlegide bụ afọ 4.8), ma e jiri ya tụnyere ìgwè ndị ọrịa na-enwe njikwa ọkọlọtọ (nkezi HbAlc uru bụ 7.3% ) ekwenti na enwere ikelata nsogbu ihe mgbochi nsogbu nke micro- na macrovascular (site na 10%) n'ihi mbelata di egwu na nsogbu nke ibute oria microvascular (site na 14%), oge Itijah na progression nke microalbuminuria (9%), gbasara akụrụ nsogbu (11%), mmalite na progression nke nephropathy (21%), na mmepe nke macroalbuminuria (30%).

Mgbe ị na-edepụta gliclazide, njikwa glycemic siri ike nwere uru dị ukwuu nke anaghị ekpebi nsonaazụ nke ọgwụgwọ na ọgwụ antihypertensive.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, glycoside na-etinye obi gị dum na ngari nri site na 100%. Ihe dị n'ime ya na plasma ọbara na-abawanye nwayọ n'ime awa isii mbụ, ntinye ahụ na-akwụsi ike ruo awa 6-12. Ogo ma ọ bụ ogo nke nnabata gliclazide bụ ihe oriri n’onweghị.

Ihe dị ka 95% nke ihe na-arụ ọrụ na-ekekọta protein protein. Olu nke nkesa dị ihe dịka 30 lita. Ceptionnabata Gliclazide MV na usoro nke 60 mg otu ugboro kwa ụbọchị na-enye gị ohere ịnwe ntinye ọgwụgwọ gliclazide na plasma ọbara ruo awa 24 ma ọ bụ karịa.

Metabolism nke Gliclazide na-aputa ihe na mbu na imeju. Achọghị ọgwụ metabolites na-arụ ọrụ nke ọgwụ a na plasma. A na - ekepụta Gliclazide site na akụrụ n'ụdị metabolites, ihe dịka 1% apụtaghị na mmamịrị ahụ. Oge ndụ ọkara bụ awa iri na isii (ihe ngosi nwere ike ịdị iche site na awa iri na abụọ ruo iri abụọ).

Edere mmekọrịta kwụ ọtọ n’etiti ọgwụ a nabatara maka ọgwụ a (ọ karịrị ihe karịrị 120 mg) na mpaghara dị n’okpuru usoro ụlọ ọgwụ ọgwụ “ịta - oge”. N'ime ndị ọrịa agadi, enweghị mgbanwe mgbanwe dị ukwuu na ụlọ ọgwụ n'usoro ọgwụ.

Ihe ngbanwe

• 1dị 1 nke ọrịa shuga mellitus (insulin-dependance),
• Ọrịa ndị na-emetụta oke umeju na akụrụ,
• Ketoacidosis
• Ọrịa mamịrị na precoa
• Ejiri nkwekọrịta na imidazole (gụnyere miconazole),
• Hypersensitivity na sulfonamides na sulfonylureas.

A naghị akwado iji Glyclazide MV maka ụmụ nwanyị na-ete nwa na ụmụ nwanyị dị ime.

Ntụziaka maka iji Gliclazide MV: usoro na usoro onunu ogwu

A na -ekwu Gliclazide MV tupu nri.

Ọtụtụ ọgwụ ị theụ ọgwụ ahụ bụ ugboro 2 n'ụbọchị.

Dọkịta na-ekpebi ọgwụ ụbọchị ọ bụla n'otu n'otu, dabere na ngosipụta nke ọrịa na ọrịa mgbatị, na afọ na-enweghị isi na awa 2 mgbe nri gasịrị.

Dịka iwu, usoro izizi bụ 80 mg kwa ụbọchị, nkezi nkezi bụ 160-320 mg kwa ụbọchị.

Ntụziaka pụrụ iche

Na ọgwụgwọ nke ọrịa mellitus na-abụghị insulin na-akpata, a ga-eji Gliclazide MV n'otu oge yana nri nwere obere kalori nwere obere carbohydrates.

N'oge usoro ọgwụgwọ, ịkwesịrị ileba anya n'ihe ọmụmụ kwa ụbọchị na ọkwa glucose, yana ọkwa glucose n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri.

Site na usoro ịwa ahụ ma ọ bụ ịgwọ ọrịa shuga mellitus, enwere ike ịtụle ọgwụ insulin.

N'ihe banyere hypoglycemia, ọ bụrụ na onye ọrịa maara, a ga-eji ọnụ gluga (ma ọ bụ mmiri shuga). N'ọnọdụ nke mmụọ, akpịrị ga-achịkwa glucose (intravenously) ma ọ bụ glucagon (subcutaneously, intramuscularly or intravenously). Iji zere ịmaliteghachi hypoglycemia mgbe mweghachi nke nsụhọ, ekwesịrị inye onye ọrịa ahụ nri nwere carbohydrate.

Ekwesighi iji gliclazide n'otu oge na cimetidine.

Site na iji gliclazide na verapamil jikọtara ọnụ, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose n'ọbara, yana acarbose, iji nlezianya nyochaa ma mezie usoro nchịkwa nke ndị na-ahụ maka hypoglycemic dị mkpa.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Ndị ọrịa na-ewere Glyclazide MV kwesịrị ịma nke ga-ekwe omume mgbaàmà hypoglycemia ma dọọ aka ná ntị banyere mkpa ọ dị ịkpachara anya mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ụfọdụ ọrụ chọrọ mmeghachi omume psychomotor ozugbo, karịsịa na mmalite ọgwụgwọ.

Ime na lactation

Enweghị ahụmịhe banyere nhọpụta nke Gliclazide MV nye ụmụ nwanyị dị ime. Mmụta n'ime anụmanụ anabataghị ọnụnọ nke njiri teratogenic. Na enweghi ụgwọ zuru oke maka ọrịa mellitus n'oge ọgwụgwọ, enwere ihe ọghọm nke ibute ọrịa afọ na - ebu n'afọ, nke nwere ike belata nchịkwa zuru oke. Kama gliclazide n'ime ụmụ nwanyị dị ime, a na-atụ aro iji insulin, nke bụkwa ọgwụ ịhọrọ maka ndị ọrịa na-eme atụmatụ ịtụrụ ime, ma ọ bụ ndị tụụrụ ime n’oge ọgwụgwọ Gliclazide MV.

Ebe ọ bụ na enweghị ozi banyere ị ofụ ọgwụ ike na-arụ ọrụ n'ime mmiri ara, na ụmụ amụrụ ọhụrụ enwere ihe ọghọm nke ịmalite hypoglycemia neonatal, na-ewere Gliclazide MB n'oge a na-enye nwa ara.

Mkparịta ụka ọgwụ ọjọọ

Site na iji Gliclazide MV jikọtara ọnụ na ọgwụ ụfọdụ, mmetụta ndị na-adịghị mma nwere ike ime:

• Ihe ndi Pyrazolone, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): ike nke ike hypoglycemic nke glyclazide,
• Ndị na - eme nhọrọ beta-ahọrọ: enwere ike ịba ụba hypoglycemia, ịba ụba ọsụsọ na ịma jijiji nke tachycardia na ịma jijiji nke njirimara hypoglycemia,
• Gliclazide na acarbose: uto hypoglycemic mmetụta,
• Cimetidine: ịba ụba ịba ụba nke gliclazide plasma (hypoglycemia siri ike nwere ike ịmalite, gosipụtara n'ụdị nkụda mmụọ nke sistemụ akwara na ụbụrụ na-enweghị isi),
• Glucocorticosteroids (gụnyere ụdị usoro onodu ogwu), diuretics, barbiturates, estrogens, progestin, ọgwụ estrogen-progestogen jikọtara ọnụ, diphenin, rifampicin: mbelata mmetụta hypoglycemic nke glycazide.

Ihe analogues nke Gliclazide MV bụ: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeton MV, Diabefarm MV, Diabinax, Diabetalong.

Nyocha na Gliclazide MV

Gliclazide MV bụ nke sitere n'ụkpụrụ nke sulfonylurea nke ọgbọ nke abụọ ma nwee mmetụta dị iche iche nke usoro hypoglycemic, nke kọwara site na ịdị elu dị elu maka ndị na-anabata mkpụrụ ndụ 2 (ihe 2-5 dị elu karịa n'ọgbọ gara aga nke ọgwụ). Ngwongwo ndị a na-enye gị ohere iji mmetuta ọgwụgwọ dị ntakịrị ma belata mmeghachi omume na-adịghị mma.

Dabere na nyocha, a na-eji MV Gliclazide mee ihe maka nsogbu nke ọrịa shuga mellitus (retinopathy, nephropathy na ọdịda akwara na-adịghị ala ala, angiopathy). Nke a bụ akụkọ sitere n’aka ndị ọrịa ebugharị ịnata ọgwụ a. Nke a bụ n'ihi eziokwu ahụ bụ na otu n'ime glycazide metabolites na-emetụta microcirculation nke ukwuu, na-ebelata ogo angiopathy na ihe ize ndụ nke ịmalite nsogbu microvascular (nephropathy na retinopathy). N'otu oge ahụ, ọbara ọgbụgba n'ime conjunctiva na-emekwa kawanye mma na akwara vaskụla na-apụ n'anya.

Ọtụtụ ndị ọkachamara na-ekwusi ike na n'oge ọgwụgwọ Gliclazide MV, ọ dị mkpa iji zere agụụ ma nye nri maka nri nwere carbohydrates. Ma ọ bụghị ya, megide ụdị nri nwere kalori na oke mgbatị ahụ, onye ọrịa ahụ nwere ike ịmalite hypoglycemia. Site na nrụgide anụ ahụ, a chọrọ ndozi dose. N'ime ụfọdụ ndị ọrịa, mgbe ha drinkingụsịrị mmanya mgbe a na-eji Gliclazide MV, a chọpụtara ihe mgbaàmà hypoglycemia.

A naghị akwado Gliclazide MV maka ndị ọrịa merela agadi nwere ike ịmalite hypoglycemia, yabụ, na nke a, ọ bara uru iji ọgwụ na-eme mkpụmkpụ.

Ndị ọrịa na-ahụta ịdị mma nke iji gliclazide n'ụdị nke mbadamba ihe ndozi emegharị: ha na-eme ihe nwayọ karị, a na-ekesasịkwa akụkụ ahụ na-arụ ọrụ n'ime ahụ niile. N'ihi nke a, enwere ike ị theụ ọgwụ ahụ otu oge kwa ụbọchị, yana usoro ọgwụgwọ ya bụ ugboro 2 erughị nke gliclazide ọkọlọtọ. Enwekwara akụkọ na site na usoro ọgwụgwọ ogologo oge (afọ 3-5 site na mmalite nke nchịkwa), ụfọdụ ndị ọrịa zụlite nguzogide, nke chọrọ nchịkwa nke ọgwụ shuga ndị ọzọ.

Usoro onunu ogwu na nhazi

Ọ bụ dọkịta nke bịara na-ekpebi ọgwụ ole ọ ga-a drugụ maka ọgwụ ahụ. N'okwu a, afọ onye ọrịa, ọnụnọ na ịdị njọ nke mgbaàmà nke ọrịa ahụ, yana ọkwa glycemia na-ebu ọnụ na awa 2 mgbe nri gachara.

Dabere na ntuziaka maka Gliclazide, usoro izizi ụbọchị kwa ụbọchị bụ 80 mg, nkezi bụ 160 mg, ikike kachasị anabata bụ 320 mg. Ekwesịrị ị drugụ ọgwụ ahụ ugboro abụọ n'ụbọchị 30-60 nkeji tupu nri.

Ọgwụ izizi nke MV Glyclazide bụ 30 mg. Ọ bụrụ na ọgwụgwọ ọgwụgwọ ezughi oke ihe dị ka otu ugboro n’izu abụọ ọ bụla, a ga-eji nwayọ belata ọgwụ ahụ ka ọ bụrụ nke kachasị elu kwa ụbọchị nke 120 mg (mbadamba 4) Ana-ewere mbadamba ntọhapụ gbanwere otu ugboro kwa ụbọchị n’oge nri ụtụtụ.