ZENTIVA METFORMIN

Metformin-Zentiva bụ ọgwụ achọrọ maka ọgwụgwọ ụdị ọrịa shuga mellitus nke 2 (DM 2). Onye na - emepụta ihe - Sanofi India Ltd. / Zentiva. Akwukwo ndi biguanides. Na mgbakwunye na ebumnuche bụ isi, ọ na-agbada cholesterol na kilogram ọzọ. Isi ihe na - arụ ọrụ bụ metformin hydrochloride.

Ngwá ọrụ na-enyere aka belata imepụta glucose site na umeji, na-egbu oge ịmịcha ya na ngwe, ma na-egbochi njikọ nke abụba. Na ntinye n’ime akwara, uche insulin na-abawanye. Metformin nwere mmetụta dị mma na metabolism lipid. Na-ebelata cholesterol, LDL, triglycerides. A na-ebelata mkpụkọ shuga n'ime ọbara site na ịkwụsịlata glucose. Ka omumu akwukwo, ahutara na ahu otutu ahu ya bu ihe ozo.

Ihe ngosi maka ojiji

Edere ọgwụ ahụ n'ọnọdụ ndị a:

• ịgwọ ụdị ọrịa shuga 2 dị ka ọgwụgwọ anụ ahụ,
• ịgwọ ọrịa shuga 2dị nke Abụọ nke insulin ma ọ bụ ọgwụ ndị ọzọ na-ebelata shuga,
• Mbelata ndaghari site na sisitemu obi na ndi mmadu nwere oria 2,
• ọgwụ siri ike na ọgwụgwọ oke ibu.

Ntụziaka maka ojiji

Edere ọgwụ ahụ maka ndị okenye na ụmụaka site na afọ 10 dịka atụmatụ a:

1. Monotherapy ma ọ bụ ihe jikọtara ya na ọgwụ ndị ọzọ nwere tableted

Ha na - amalite usoro ogwu site na obere doses - 500 mg 2-3 ugboro n'ụbọchị. Mgbe izu 1-2 gachara, ọ bụrụ na ọ dị mkpa, dozie usoro ahụ. Oke kachasị bụ 2000-3000 mg na usoro onwa atọ.

A na-eri ọgwụ ahụ 500-850 mg 2-3 ugboro n'ụbọchị. Imezi inje insulin.

1. Ndị nwere ogo obere akụrụ na-amalite ị takingụ ọgwụ mg 500 ugboro otu ugboro n'ụbọchị. Usoro onunu ogwu kacha bu 1000 mg ugboro abuo.

Ihe ngbanwe

A na-egbochi ọgwụ a na mkpụrụokwu ndị a:

• hypersensitivity nke mmiri ọgwụ,
• agafeghị oke / nnukwu akwara ọdịda,
• obi obara
• mmanya riri ahụ
• obi nko nso,
• imeju imeju
• afọ ime / lactation.

Nsonaazụ

Ndị ọrịa na-anabata Metformin nke ọma, mana n'ọnọdụ ụfọdụ, a na-achọpụta mmetụta ọjọọ ndị a:

• mwepu absorption nke B12 (iji ogologo oge),
• eriri afọ
• uto mebiri
• akpụkpọ mmeghachi omume
• lactic acidosis.

Mmekọrịta na ọgwụ ndị ọzọ

Ọgwụ ahụ enweghị dakọtara na ethanol. Insulin, ihe ndi a na-eji salicylic acid, MAO inhibitors, sulfonylureas, nootropics na-eme ka metformin rụọ ọrụ. Ihe mgbochi a na-a Oụ n’ọnụ, homonụ, akwara ozi, niacin, phenothiazines belata mmetụta nke ọgwụ.

Usoro na nchekwa nke ọgwụ

Metformin Zentiva achọghị ọnọdụ nchekwa. A na-echekwa ya na okpomọkụ nke ogo 25 na ngwugwu mbụ. Ndụ shelf bụ afọ 3.

Ahịa ọgwụ nwere ọtụtụ ọgwụ dabere na metformin.

Aha ndị ama ama ama:

• Bagomet, Argentina,
• Glycomet, India,
• Glucophage, France,
• Insufor, Turkey,
• Metformin Sandoz, Slovenia / Poland,
• Siofor, Germany.

Mpempe mwepụta, ihe mejupụtara

Mbadamba mbadamba, nke ihe mkpuchi na-acha uhie uhie, bụ nke gbara agba, biconvex, nwere nsogbu nke nkewa abụọ.

PRING sodium carboxymethyl stachi - 40 mg, povidone 40 - 80 mg, colloidal silicon dioxide - 14 mg, ọka ọka - 20 mg, magnesium stearate - 6 mg.

Ihe mejupụtara nke uwe ihe nkiri: sephyphilm 752 white (hypromellose - 35-45%, microcrystalline cellulose - 27-37%, macrogol stearate - 6-10%, titanium dioxide - 18-22%) - 20 mg, macrogol 6000 - 0.23 mg.

10 PC. - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (6) - ngwugwu nke kaadiboodu.
10 PC. - blisters (9) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Ọgwụ hypoglycemic maka iji ọnụ mee ihe. Metformin bụ biguanide nwere mmetụta hypoglycemic, nke na-ekpebi mbelata basal (ibu ọnụ) na postprandial (awa 2 mgbe mmalite oriri) oriri ịba ụba nke plasma. N'adịghị ka usoro sulfonylurea, metformin anaghị akpali akpali insulin site na mkpụrụ ndụ beta nke pancreatic ma ghara ibute oria hypoglycemia.

Na-eme ka mmata nke ndị na-anabata ihe na insulin na itinye glucose site na sel. Na-ebelata mmepụta glucose imeju site na igbochi gluconeogenesis na glycogenolysis. Na-egbu oge itinye glucose umeji.

Metformin na-akpali njikọ nke glycogen njikọ intracellular site na ime ihe na glycogen synthase. Na-eme ka ikike ibuwanye nke ndị na-ebuga glucose ụdị ọ bụla.

Metformin nwere mmetụta bara uru na metabolism lipid: ọ na-ebelata cholesterol zuru oke, LDL na triglycerides.

Mgbe ị na-ewere metformin, ịdị arọ nke onye ọrịa ahụ ọ na-adịgide ma ọ bụ na-ebelata obere oge.

N'ime ndị ọrịa dị afọ 10 ruo afọ iri abụọ bụ ndị mesoro metformin maka afọ 1, ndị na - ahụ maka njikwa glyce bụ nke ndị okenye.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-etinye metformin n’ime eriri afọ. Na kacha mezuru 2.5 awa mgbe ingestion. Bioavailability maka usoro onunu ogwu nke 500 na 850 mg na ahụike bụ 50-60%. Nchoputa nke metformin mgbe insolite zuru ezu juru eju. A na-eche na ọgwụ pharmacokinetics nke nnabata metformin bụ nke na-abụghị ahịrị. Mgbe ejiri metformin mee ihe na usoro ndị a tụrụ aro yana dabere na usoro a tụrụ aro, C ss na plasma na-enweta n'ime awa 24-48 ma na-abụkarị ihe na-erughị 1 /g / ml. C max metformin anaghị agafe 5 μg / ml, ọbụlagodi mgbe ị na-eji ọgwụ ahụ na oke doses.

Nri na-ebelata ogo ma na-agbadata mmata nke metformin. Mgbe ịbatara mbadamba ụrọ 850 mg, mbelata na C max nke 40%, mbelata na AUC nke 25% yana mmụba nke 35 nkeji oge iji rute C max.

A na-ekesa Metformin ngwa ngwa na anụ ahụ, ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Metformin banye n’ime sel ọbara. C max n'ime ọbara dị ala karịa C max na plasma ọbara, a na-enwetakwa ihe dị ka n'otu oge. Mkpụrụ ndụ ọbara uhie, n'ọdịdị ọ bụla, bụ ebe ebusa nkesa nke abụọ. Agba nke d d na nkezi nke 67-276 lita.

Ọ bụ akụrụ na - agbanwegharị Metformin na - agbanweghi agbanwe, ọ bụ metabolized obere nwa, achọpụtabeghị metabolites.

Mgbe ị theụsịrị ọgwụ ahụ n’ime eriri afọ, 20-30% nke ihe ndị a na-ejighi ya. Mkpochapu akwara nke metformin karịrị 400 ml / min, nke na-egosi mkpochapụ nke metformin site na mkpochasị ngwongwo na-ekpo ọkụ na mmiri. Mgbe nchịkwa ọnụ gachara, T 1/2 bụ ihe dịka awa 6.5.

N'ihe banyere ọrụ akụrụ na - arụ ọrụ, nchịkọta ọgwụ ga - ekwe omume, nke na - eduga n'ịba ụba nke mkpokọta metformin na plasma ọbara.

Ndị otu ọrịa pụrụ iche

Ndị ọrịa nwere ọrụ mgbazinye nsogbu. Ihe omuma ndi di na ndi oria nwere ezughi oke gbasara akuru ndi pere mpe anaghikwa ekwe ka atule ihe metformin na ndi otu a, dika esi eme ya n’otu n’otu.

Ndị ọrịa dị na nwata. Mgbe otu usoro metformin na-eji otu ọgwụ dị 500 mg, a chọpụtara profaịlụ ọgwụ ọgwụ nke yiri nke a hụrụ n'etiti ndị okenye nwere ahụike. Mgbe ojiji nke metformin ugboro ugboro na dose nke mg mg 500 ugboro 2 / ụbọchị maka ụbọchị 7 na ụmụaka, C max na AUC 0-t belata
odika 33% na 40%, n'otu n'otu, jiri ya tụnyere ụkpụrụ nke paramara ndị a na ndị okenye nwere ọrịa shuga bụ ndị natara metformin na usoro ọgwụ nke 500 mg ugboro abụọ kwa ụbọchị maka ụbọchị 14. Ebe ọ bụ na ahọrọ ọgwụ nke ọgwụ a n'otu n'otu dabere na ọkwa nke glycemia, data ndị a nwere obere ọgwụ.

Usoro onunu ogwu na nhazi

A na-ewere ọgwụ ọnụ. Mbadamba ga-achịrị dum n’oge ma ọ bụ ozugbo nri were obere mmiri mmiri.

Ekwesịrị ị Metụ ọgwụ Metformin Zentiva kwa ụbọchị, na-enweghị nkwụsị. Ọ bụrụ na a kwụsịrị ọgwụgwọ, onye ọrịa ahụ kwesịrị ịgwa dọkịta.

Monotherapy na ọgwụgwọ nkwonkwo yana njikọta ọnụ nke ndị ọzọ na-ekwu okwu hypoglycemic

Usoro ọgwụgwọ mbụ, dịka iwu, bụ 500 mg ma ọ bụ 850 mg ugboro abụọ / ụbọchị mgbe ma ọ bụ n'oge nri. Mmụba na-eji nwayọọ nwayọọ na-abawanye na dose ga-ekwe omume dabere na ntinye glucose n'ọbara.

Daysbọchị iri itoolu nke iji rụọ ọrụ, a ga-emegharị dose ahụ yana iburu nsonaazụ nke ịtụle mkpokọta glucose na plasma ọbara. Mmụba na-eji nwayọ nwayọ nwayọ pụrụ inye aka melite nnabata afọ.

Ọgwụ mmezi na-abụkarị 1500-2000 mg / ụbọchị. Iji belata nsonaazụ si eriri afọ, a ga-ekewa ihe ị na-eme kwa ụbọchị n'ime usoro 2-3. Ogo kachasị bụ 3000 mg / ụbọchị, kewara 3 doses.

Enwere ike ịnyefe ndị ọrịa na-a metụ metformin na onunu nke 2000-3000 mg / ụbọchị site na ị were mbadamba metformin na usoro nke 500 mg gaa na ị were mbadamba metformin na usoro nke 1000 mg. Ihe kachasị atụ aro ị bụ
3000 mg / ụbọchị, kewara 3 doses.

N'ihe banyere ịhazi mgbanwe site na ị takingụ ọgwụ hypoglycemic ọzọ: ị ga-akwụsị ị takingụ ọgwụ ọzọ wee malite ị startụ Metformin Zentiva na usoro egosipụtara.

Nchikota insulin

Iji nweta ike nchịkwa glucose ọbara dị mma, enwere ike iji metformin na insulin mee ihe njikọta. Usoro mbụ nke Metformin Zentiva, dịka iwu, bụ 500 mg ma ọ bụ 850 mg ugboro abụọ / ụbọchị, ebe ahọpụtara insulin na ndabere nke mgbanye glucose ọbara.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

Enwere ike iji Metformin rụọ ọrụ na ndị ọrịa nwere obere akwara ezughị oke (CC 45-59 ml / min, GFR 45-59 ml / min / 1.73 m 2 nke anụ ahụ) naanị na enweghị ọnọdụ ndị ọzọ nke nwere ike ịbawanye ihe egwu lactic acidosis, yana n'okpuru ọnọdụ ndị na - eme mgbanwe dose: ọgwụ mbụ nke Metformin Zentiva bụ 500 mg ma ọ bụ 850 mg 1 oge / ụbọchị.

Oke kachasị bụ 1000 mg / ụbọchị, kewara abụọ. Achọrọ iji nlezianya na-arụ ọrụ gbasara akụrụngwa (ọnwa 3-6 ọ bụla).

Ọ bụrụ na QC 2 nke anụ ahụ dị elu, a ga-akwụsị Metformin Zentiva ozugbo.

Ndị okenye na-arịa ọrịa

N'ihi ọrụ gbasara akụrụ nwere ike ịdapụta, a ga-ahọrọ ọgwụ ọgwụ Metformin Zentiva na ndị ọrịa agadi n'okpuru nlele anya mgbe niile na-egosi ihe gbasara ọrụ akụrụ (kpebie itinye uche nke creatinine n'ọbara ọbara ọbụlagodi ugboro 2-4 n'afọ).

Childrenmụaka na ndị nọ n'afọ iri na ụma

N'ime ụmụaka gbara afọ 10 na karịa, a ga-eji ọgwụ Metformin Zentiva mee ihe dịka monotherapy yana yana insulin. Usoro ọgwụgwọ mbụ, dịka iwu, bụ 500 mg ma ọ bụ 850 mg 1 oge / ụbọchị mgbe ma ọ bụ n'oge nri. Mgbe ụbọchị 10-15 gachara, a ga-agbanwe ọgwụ ya dabere na-egosi mgbanye glucose n'ọbara. Ọgwụ kachasị kwa ụbọchị bụ 2000 mg, kewara 2-3 usoro.

Dodoụbiga ya ókè

Mgbaàmà: mgbe etinyere ya na ọkara nke 85 g (ugboro 42.5 karịa kwa ụbọchị), ahụghị mmepe nke hypoglycemia. Site na oke mmeri nke metformin, acidctis lactate nwere ike ịmalite. Lactic acidosis bụ ihe mberede ma chọọ ọgwụgwọ inpatient. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ.

Ihe mgbaàmà izizi nke lactic acidosis bụ ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, iwetulata ahụ, mgbu nke afọ, mgbe nke ahụ gasịrị, iku ume ọsọ ọsọ, nkụda mmụọ, mmetụ mmụọ na mmepe nke coma nwere ike ime.

Na nzụlite nke oke ọgwụ mejupụtara nke metformin, pancreatitis nwere ike ime.

Ọgwụgwọ: a bụrụ ihe ịrịba ama nke lactic acidosis, a ga-akwụsị ọgwụgwọ na metformin ozugbo, a ga-ebunye onye ọrịa ngwa ngwa n'ụlọ ọgwụ, a ga-ekpebi itinye uche nke lactic acid na plasma ọbara wee chọpụta nchoputa ahụ. Usoro kachasị dị irè maka iwepu lactic acid na metformin n'ahụ ahụ bụ hemodialysis. A na-eme ọgwụgwọ Symptomatic.

Mmekọrịta ya na l / s ndị ọzọ

Ndị ọrụ rediopa nwere iodine

Nlekọta intravascular nke iodine nwere radipaque nwere ike iduga mmepe nke ọdịda akụrụngwa na-arụ ọrụ, si otú a na-abawanye mkpokọta metformin na ihe ize ndụ nke lactic acidosis. N'ime ndị ọrịa nwere GFR> 60 ml / min / 1.73 m2 nke mpaghara elu ahụ, a ga-akwụsị metformin tupu ma ọ bụ n'oge nyocha X-ray ma ghara ịmalitegharia n'ime awa 48 ka emechara ya, ọ bụrụ na egosipụtara ọrụ akụrụ dị mma. N'ime ndị ọrịa nwere ọrụ mgbazi oruru nke ịkpa oke (GFR 45-60 ml / min / 1.73 m 2), a ga-akwụsị iji metformin awa 48 tupu nchịkwa nke iodine nwere ọdịiche ma maliteghachi tupu 48 awa gụchara ọmụmụ a ma ọ bụ mgbe nyochachara nyocha. gbasara akụrụngwa na enweghị ihe ịrịba ama nke nbibi ya.

X intoụbiga ihe ọ alcoholụ theụ na-egbu egbu egbu, ihe ize ndụ nke ịmalite ọrịa lactic acidosis na-abawanye, karịsịa n'ihe ụnwụ nri ma ọ bụ erighị nri na-edozi ahụ, na-agbaso nri kalori dị ntakịrị ma ọ bụ nke imeju. Mgbe ị na-a theụ ọgwụ ahụ, a ga-ezere mmanya na ọgwụ nwere ethanol.

Mgwakọta chọrọ ịkpachara anya

Ekwesighi ka eji Danazol eme ihe oge a iji zere uto hyperglycemic nke ikpeazụ. Ọ bụrụ na ọgwụgwọ na danazol dị mkpa ma kwụsịchaa nke abụọ, a chọrọ idozi dose nke metformin n'okpuru njikwa glucose ọbara.

Chlorpromazine mgbe ewere ya na oke onunu (100 mg / ụbọchị) na-eme ka ịbawanye ụba nke glucose n'ọbara, na-ebelata ntọhapụ nke insulin. Na ọgwụgwọ nke ọgwụ mgbochi na mgbe ịkwụsị ọrụ ha, achọrọ ịgbatị dose nke metformin n'okpuru njikwa glucose ọbara.

GCS nke systemic na ime ihe dị na mpaghara belata nnabata glucose, dịkwuo n'ọbara nke glucose n'ọbara, mgbe ụfọdụ na-akpata ketosis. Na ọgwụgwọ nke corticosteroids na mgbe ha kwụsịrị ị ,ụ ha, a na-achọ nhazigharị nke metformin n'okpuru njikwa nke glucose n'ọbara.

Diuretics (ọkachasị loopbacks)

Ojiji a na - eme "akaghị ihe" diuretics nwere ike ibute mmepe nke lactic acidosis n'ihi ọdịda akụrụngwa nke arụ ọrụ ga-eduga. Ekwesighi inye ndị ọrịa Metformin inye ọgwụ ma ọ bụrụ na CC dị n'okpuru 60 ml / min.

Beta 2 -adrenomimetik na ụdị injections

Beta 2 -adrenergic agonists na-eme ka mkpokọta glucose dị n'ọbara n'ihi mkpali nke-2 -adrenoreceptors. N'okwu a, ọ ga-adị mma ka ị lebanye anya mgbe niile oke glucose na ọbara. Ọ bụrụ na ọ dị mkpa, a na-atụ aro insulin.

N'iji oge nke ọgwụ ndị a dị n’elu, enwere ike idozi sọọsọ metformin n’oge ọgwụgwọ ma ọ bụ nkwụsị ya.

Ọgwụ antihypertensive, ewezuga ndị na - egbochi ACE, nwere ike gbanwee oke glucose n'ọbara. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịhazigharị ọgwụ nke metformin.

Nri nke sulfonylureas, insulin na acarbose

N'iji imezu ihe eji eme ya na metformin, mmepe nke hypoglycemia kwere omume.

N'iji imezu ihe eji eme ya na metformin, mmepe nke hypoglycemia kwere omume.

Na-abawanye mmịba ma na-abawanye C max nke metformin.

Ọgwụ cationic

Amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim na vancomycin, ndị na-akpọ aha tubules, na-asọ mpi na metformin maka usoro ụgbọ njem tubular ma nwee ike iduga mmụba na C max ruo 60%.

Enwere ike belata mmetụta hypoglycemic nke metformin site na phenothiazines, glucagon, estrogens, gụnyere mgbochi mkpịsị ede, phenytoin, sympathomimetiks, nicotinic acid, isoniazid, ndị na-egbochi ọwa calcium na-egbochi.

Levothyroxine nwere ike belata mmetụta hypoglycemic nke metformin. A na-atụ aro maka nyocha ọbara glucose ọbara, ọkachasị n'oge nnabata ma ọ bụ nkwụsị nke ọgwụgwọ homonụ, ọ bụrụ na ọ dị mkpa, ekwesịrị idozigharị usoro nke metformin.

Site na ojiji nke metformin na NSAIDs, MAO inhibitors, oxytetracycline, ihe dị iche iche nke fibroic acid, cyclophosphamide, probenecid, chloramphenicol, ọgwụ antioxideam nke sulfonamide, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.

N'ime ndị ọrụ afọ ofufo nwere ahụ ike na ọmụmụ n'ọtụtụ metformin na propranolol, yana metformin na ibuprofen, enweghị mgbanwe na paradaịs ọgwụ ha.

Metformin nwere ike belata mmetụta ọgwụgwọ anticoagulant fenprocoumone. Mgbe ejikọtara ọnụ, a na-atụ aro iji nlezianya nyochaa MHO.

N'oge ime na lactation

Ọrịa shuga na-achịkwaghị achịkwa n'oge afọ ime nwere ihe ka ukwuu n'ihe ize ndụ nke arụrụala ịmụ nwa na ọnwụ mmadụ na-anwụ. Onu ogugu data n’egosi na iwere metformin n’ime ndi nwanyi di ime emeghi ka nsogbu nke imu nwa buru n’afọ puta. Ọmụmụ anụmanụ egosibeghị mmetụta na-emerụ ahụ na afọ ime, mmepe nke ẹmbrayo ma ọ bụ nwa n’afọ, ụzọ ọrụ na mmepe ịmụ nwa.

Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n'ihe gbasara ịtụrụ ime na ndabere nke were metformin, ekwesịrị ị kwụsị ọgwụ ahụ ma ekwenyekwa ọgwụ insulin.

Ọ dị mkpa idobe ọkwa glucose ọbara na ọkwa dịkarịrị nso na nkịtị iji belata ihe egwu dị njọ na nwa ebu n’afọ.

Metformin na-abanye n’ime mmiri ara. Achọpụtaghị nsonaazụ n'akụkụ ụmụ amụrụ ọhụrụ / ụmụ ọhụrụ mgbe ha na-etinye metformin. Agbanyeghị, n'ihi data dị ụkọ, a naghị atụ aro ka ị theụ ọgwụ ahụ n'oge a na-enye nwa ara. Ekwesịrị ime mkpebi ịkwụsị inye ara, na-eburu n'uche uru ị benefitsụ ara na ihe ọghọm nke nsonaazụ nwatakịrị nwere.

Nsonaazụ

Mgbe ị na-eji Metformin, nsonaazụ ndị a na-esote nwere ike ịpụta, nke kewara gaa na klaasị sistemu na klas dị na MedDRA. Mkpebi ugboro ole mmetụta dị ka nhazi WHO si dị: oge ​​mgbe (≥10%), ọtụtụ mgbe (≥1% na ọbara na sistem lymphatic: ugboro ole amaghi - anaemia hemolytic.

Site na akụkụ nke metabolism na nri nri: ọ dịkarịghị - acid laisate, belata vitamin B 12 n'ime ndị ọrịa nwere ọrịa megaloblastic anaemia, amabeghị ugboro ole a - ọrịa neuropathy na-emetụta ndị ọrịa nwere ụkọ vitamin B 12.

Site na usoro ụjọ ahụ: ọtụtụ mgbe - nsị nke uto, a maghị ugboro ole - encephalopathy.

Site na ngwe nri: otutu oge - ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, afọ na-egbu, agụụ. Mmetụta ndị a na - achọghị mgbe niile na - amalite n'oge ọgwụgwọ na n'ọtụtụ oge kpebiri n'onwe ha. Iji gbochie ihe omume ha, a na-atụ aro ị doseụ ọgwụ metformin kwa ụbọchị maka onyo abụọ ma ọ bụ atọ n'oge nri ma ọ bụ mgbe nri ahụ gasịrị. Ntinye nwayọ nwayọ nke dose ọgwụ nwere ike inye aka melite nnabata site na mgbaze nri.

N’akụkụ anụ ahụ na akwara dị n’ime ala: ọ na - esiri ike - erythema, itching skin, urticaria, ugboro ole amaghi - photoensitivity.

Na akụkụ nke imeju na ọnya biliary: ọ na - adịkarịghị ike - ụba ọrụ nke hepatic transaminases ma ọ bụ ịba ọcha n'anya, na-apụ n'anya mgbe ọpụpụ ọgwụ.

Mmetụta nsonaazụ nke ụlọ nyocha na usoro ọmụmụ: amabeghị ugboro ole a - mbelata mkpokọta nke TSH na plasma na ndị ọrịa nwere hypothyroidism, hypomagnesemia megide ndabere nke afọ ọsịsa.

Childrenmụaka na ndị nọ n'afọ iri na ụma

Ebuputara data, data banyere iji aha ndebanye aha, yana nsonaazụ nke nnwale ụlọ ọgwụ a na - achịkwa ọnụ ọgụgụ ụmụaka pere mpe n’afọ 10-16 nke ejiri mmachi mesoo otu afọ, na - egosi na ihe ọjọọ ụmụaka na-ahụ na okike na ogo siri ike na ndị nọ okenye ọrịa.

Ntụziaka pụrụ iche

Lactic acidosis bụ obere, mana njọ (ọnwu dị elu na enweghị ọgwụgwọ ozugbo), nsogbu metabolic nke nwere ike ime n'ihi mmụpụta nke metformin. Enwere akụkọ banyere ikpe nke lactic acidosis n'oge ọgwụgwọ na metformin na ndị ọrịa nwere ọrịa mellitus yana nnukwu ọrịa gbasara akụrụ ma ọ bụ nnukwu nkwarụ nke ọrụ akụrụ. Ekwesịrị ị attentiona ntị na ọnọdụ enwere mgbe ezughi oke akwara nwere ike ime, dịka ọmụmaatụ, n'ihe banyere akpịrị ịkpọ nkụ (na ọnya afọ ma ọ bụ ọgbụgbọ) ma ọ bụ mmalite ọgwụgwọ antihypertensive ma ọ bụ ọgwụgwọ ọrịa akwara (karịsịa “loopback”), yana mmalite NSAID. N'ọnọdụ ndị a nnukwu ọnọdụ, a ga-akwụsị ịgwọ ọrịa ya na Metformin Zentiva nwa oge.

Ekwesịrị ịtụle ihe ndị ọzọ metụtara ihe ize ndụ, dị ka ọrịa mellitus decompensated, ketosis, ibu ọnụ ogologo oge, ị alcoholụbiga mmanya ókè, ọrịa imeju na ọnọdụ ọ bụla metụtara hypoxia siri ike (dịka ọmụmaatụ, nkụda obi obi na-adịghị ala ala. )

E kwesịrị ịtụle ihe ize ndụ nke ịmalite lactic acidosis mgbe mgbaàmà ndị na-enweghị isi, dịka nkwarụ akwara, nsogbu nke diski diski, mgbu afọ, na asthenia siri ike. Ekwesịrị ịgwa ndị ọrịa ka ha gwa dọkịta ha ozugbo banyere ihe mgbaàmà ndị a, karịsịa ma ọ bụrụ na onye ọrịa ahụ kwagidere usoro ọgwụgwọ metformin nke ọma. N'okwu a, ọgwụgwọ Met Metinin Zentiva kwesịrị ịkwụsị, ma ọ dịkarịa ala, ruo nwa oge, ruo mgbe a ga-akọwapụta ọnọdụ ahụ. A ga-ekpebi ajụjụ nke ịmaliteghachi ọgwụgwọ ahụ n'otu n'otu, na-eburu n'uche uru / ihe nhịahụ ruru, yana na-ebukwa n'uche ọnọdụ ọrụ gbasara akụrụngwa na onye ọrịa a.

Ọrịa: lactate acidosis bụ nke iku ume acidotic na-enwe, mgbu afọ, hypothermia, sotewe. Ihe ngosi nke ulo-akwukwo gunyere: mbelata pH ọbara (ihe kariri 7.25), mkpocha nke lactic acid na plasma kariri 5 mmol / l, na ubara anionic na nha nke lactate / pyruvate. Ọ bụrụ na a na-enyo metabolic acidosis, ọ dị mkpa ịkwụsị ị metụ metformin ma gwọọ onye ọrịa ozugbo.

Ndị dọkịta kwesịrị ịgwa ndị ọrịa banyere ihe ize ndụ nke lactic acidosis na mgbaàmà ya.

Shouldkwesịrị ịkwụsị ị Metụ ọgwụ Metformin Zentiva 48 awa tupu usoro ọgwụgwọ ịwa ahụ emee n'okpuru nkụnwụ ahụ, ogwe azụ ma ọ bụ ọgwụ epidural. Enwere ike ịmaliteghachi usoro ọgwụgwọ a tupu 48 awa mgbe a wasịrị ya ahụ ma ọ bụ mgbe mweghachi nke oriri ma ọ bụ naanị na arụ ọrụ nkịtị.

N'ihi na metformin bụ akụrụ na-apụ n'anya, ekwesịrị ilebara onye na - egosi QC anya tupu ịmalite ọgwụgwọ wee mezie ya mgbe niile.

- ọbụlagodi otu ugbo n’afọ n’ime ndị ọrịa arụmọrụ arụmọrụ nkịtị,

- opekata mpe ugboro anọ n’afọ n’ime ndị ọrịa nwere ọnụ ahịa CC n’ogweghị ike nke ndị nkịtị na ndị ọrịa agadi.

Na KK 2 ahụ na-ebu ụzọ) ọgwụ ọgwụ Metformin Zentiva na-contraindicated.

Kpa mba n’arụ ọrịa n’arụ ndị okenye ọrịa anaghị abụkarị asymptomatic.

Ekwesịrị ịkpachara anya maka ịrụ ọrụ nkwụghachi ụgwọ enwere ike ịnwere ma ọ bụrụ na akpịrị ịkpọ nkụ ma ọ bụ iji ọgwụ ọgwụ antihypertensive, mmerụ ahụ (ọkachasị "loopback") ma ọ bụ NSAID. N'okwu ndị a, a na-atụ aro ka ịlele ọnọdụ ọrụ arụmọrụ tupu ịmalite ọgwụgwọ na Metformin Zentiva.

Ndị ọrịa nwere nkụda obi nwere nnukwu ihe ize ndụ nke ịmalite hypoxia na ọdịda akụrụ. N'ime ndị ọrịa nwere ọrịa obi na-adịghị ala ala, enwere ike iji ọgwụ Metformin Zentiva na-edobe ya mgbe niile maka ọrụ obi yana ọrụ akụrụ.

Ojiji nke Metformin Zentiva na contraindicated na ndị ọrịa nwere nnukwu ọrịa ma ọ bụ na-adịghị ala ala daa na hemodynamics kwụsiri ike.

Metformin emetụtaghị ọrụ omumu nke oke ma ọ bụ oke oke mgbe ejiri ya na doses ruo 600 mg / kg / ụbọchị, nke bụ ihe dị ka okpukpu atọ karịa nke kachasị na-atụ aro kwa ụbọchị na ụmụ mmadụ dabere na nsonaazụ ntụnyere dabere na mpaghara ahụ.

Childrenmụaka na ndị nọ n'afọ iri na ụma

Ekwesịrị ịchọpụta nchoputa nke ụdị ọrịa shuga abụọ nke ọrịa mellitus tupu ịmalite ọgwụgwọ na Metformin Zentiva.

N'ime ule ndị a na-ejikwa ụlọ ọgwụ a na-achịkwa na-adịgide ruo otu afọ, ahụghị mmetụta metformin na uto na uto nke ụmụaka. Agbanyeghị, n'ihi enweghị data ogologo oge, a na-atụ aro iji nlezianya nyochaa mmetụta na-esochi nke metformin na paramita ndị a na ụmụaka na-ewere Metformin Zentiva, karịsịa na ụmụaka gbara afọ 10-12.

Prekpachara anya

- Ndi oria kwesiri iso nri mgbe obula karia mgbe dum ubochi. Ndị ọrịa nwere oke ibu kwesịrị ịnọgide na-agbaso nri kalori (mana ọ bụghị ihe na-erughị 1000 kcal kwa ụbọchị).

- A ga-eme nyocha ụlọ nyocha oge niile iji chịkwaa ọrịa shuga.

-Metformin anaghị ebute hypoglycemia n'oge monotherapy, ka ọ dọọ, ọ na-adụ ịdọ aka na ntị mgbe ejiri ya na insulin ma ọ bụ ndị ọzọ hypoglycemic (dịka ọmụmaatụ, sulfonylureas, repaglinide).

- Ogologo oge ọgwụgwọ na metformin na-esolata mbelata vitamin V 12 na plasma ọbara, nke nwere ike ibute neuropathy akụkụ. A na-atụ aro maka itinye vitamin C 12 nke plasma

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Ojiji nke ọgwụ Metformin Zentiva dị ka monotherapy anaghị emetụta ikike ịkwọ ụgbọala na usoro.

Mgbe ị na-ejikọ Metformin Zentiva na ndị ọrụ hypoglycemic ndị ọzọ (gụnyere sulfonylureas, insulin, meglitinides), ọ dị mkpa ịdọ ndị ọrịa aka ná ntị banyere ike ịmalite ọnọdụ hypoglycemic nke ike ịkwọ ụgbọala na itinye aka na ọrụ ndị ọzọ dị ize ndụ nke chọrọ nlebara anya ka njọ. na mmeghachi omume psychomotor ngwa ngwa.

Metformin maka oke ibu: ntuziaka maka ojiji, nyocha na ego ole ka ọ na-eri?

Mgbe idebe mmemme pụrụ iche nke na - enyere aka belata oke ibu anaghị enye nsonaazụ a na - ahụ anya, ọtụtụ ndị na - amalite ị drugsụ ọgwụ na - enyere aka ifelata.

Otu n'ime ọgwụ ndị a bụ Metformin, nke ọ bụghị naanị na ọ na-alụ ọgụ ụma karịa, mana ọ na - eme ka metabolism dị mma ma na - eme ka akụkụ ahụ dị na - arụ ọrụ.

Agbanyeghị, ọtụtụ nwere mmasị etu esi ewere Metformin maka oke ibu iji mepụta nsonaazụ a na-ahụ anya ma nọgide na-enwe mmetụta ahụ.

Gịnị bụ metformin?

Metformin - ọgwụ, a na-akpọkwa Glucofage, dị n'ụdị mbadamba ma jiri ya belata shuga ọbara. A na-ejikarị ya agwọ ọrịa dịka ọrịa shuga.

Ọgwụ nwere ihe ndị a na-enye ọgwụgwọ na ahụ mmadụ:

• Kpochapu cholesterol ojoo ma na - egbochi ibute ọrịa atherosclerosis
• Na-egbochi omume nke ọrịa dịka ọrịa strok n'ihi ọganihu nke ọrịa shuga
• A na - eji ya egbochi mmepe nke ọrịa shuga
• Agụụ igbo

Ọgwụ nwere mmetụta ndị ọ na-achọ ma chọọ nyocha pụrụ iche na ndụmọdụ ahụike iji kọwaa ụzọ ziri ezi ọgwụ ahụ dị.

Ego ole ka ị ga-ewe?

Ego ole ka ị chọrọ ị were ihe a iji nweta nsonaazụ?

Iji gwọọ ọrịa a, ekenye onye ọrịa shuga otu onye ka ọ bụla.

Ọtụtụ mgbe, usoro ị standardụ ọgwụ ahụ bụ mbadamba abụọ kwa ụbọchị n'ụtụtụ na mgbede. A na-eji ọgwụ eji nri.

E kwesịrị iji mmiri dị ukwuu hichaa mbadamba ahụ. Dabere ogo ogo ọrịa ahụ, mmụba nke ị asụ ọgwụ dịka dọkịta depụtara ga-ekwe omume. A naghị eji ụdị ọgwụ a maka afọ erubeghị afọ iri abụọ.

Enwere m ike ifelata mgbe ị na-ewere Metformin?

Ojiji nke ọgwụ a na-ebelata nnabata shuga ma belata nguzobe anụ ahụ. N’ezie ị nwere ike belata ibu, mana ọ nwere ike tụgharịa n’ụzọ dị anya ma ọ bụrụ na ịgbasoghị iwu niile.

Iji belata ibu, ọgwụ nwere mmetụta dị mma na-eso ahụ:

• Na -ebelata oriri nke carbohydrates ma wepu ha dika eke
• Oxidizes acid na-egbochi ma gbochie ịmịcha ha
• Ọ na - egbochi oke abụba site na ịmegharị abụba ka ọ bụrụ ike maka ahụ
• Na-akwalite nkụda mmụọ glucose akụkụ
• Ọ na - ewepụ mmetụta nke agụụ mgbe niile.

Should kwesịrị ịmara na naanị ọgwụ agaghị enwe ike iwepụ ụtụ ahụ. Iji mee nke a, ị ga-ebu ụzọ leba anya n'ihe oriri dị mma, ma belata oriri nke nri na-emebi ihe. Ọ dịkwa ezigbo mkpa ịme mmega ahụ nkịtị nke ga - enyere aka ilekọta ma wusi nsonaazụ ya ike.

Kedu ka Metformin si enyere aka ifelata?

• Iji Metformin na-ebelata nnabata shuga ma na-eme ka metabolism dịkwuo elu, N'ihi nke a, abụba na-abanye obere irighiri, nke a gbanwere bụrụ nke ike, a na-ewepụ ihe ndị ọzọ abụba ahụ.
• Na mgbakwunye, a na-ekpuchi carbohydrates nke mmadụ riri na ụdị ụdị shei, nke na-egbochi mgbaze ha, N'ihi ya, a na-ewepụ ihe ndị na-enye carbohydrates n'ahụ.
• Ọgwụ na - enyere aka iwepụ cholesterol ọjọọ, nke na-abanye n’ime ahụ yana nri ratụ ratụ, ma na-eme ka ibughari nke nri na-aba n’ime ahụ, si otú a na-arụ ọrụ ha.
• Ihe oriri kwesịrị ekwesị na-enyere aka igbochi ihe ndị na-emebi ihe ịbanye na ahụ. na mkpokọta mkpụrụ ndụ abụba, na iji ọgwụ eme ihe na-ewepụ kilogram ndị ọzọ.

Etu esi a Metụ Metformin maka oke ibu?

Ọtụtụ mgbe, ị useụ ọgwụ ahụ na-apụta na enweghị ọgwụ dọkịta, yabụ na mbụ ị ga-eji ọgwụ kachasị ntakịrị.

Maka oge mbụ ụbọchị iri, a na-atụ aro ka ọ ghara iji karịa mbadamba abụọ kwa ụbọchị, n'ụtụtụ na n'anyasị. A na-ewere ngwa ahụ mgbe nri, ị ga-a ,ụ mbadamba mmiri nke nwere nnukwu mmiri.

Wepu nri dika:

• Tọ
• Oyiyi.
• Eghere.
• Ire.
• Mmanya na-egbu egbu
• Anụ oriri na azụ̀ nwere abụba.
• Ihe ọ .ụ Carụ Carbonated.
• Anwụrụ anụ.
• Ngwa soseji.
• Nri mkpọ.

Mgbe ọtụtụ izu nke ịsụ ọgwụ ọ bụla, ọ ga-ekwe omume ịbawanye ọgwụ ahụ na mbadamba atọ kwa ụbọchị. Usoro iji ọgwụ ahụ eme ihe adịghị karịa otu ọnwa, mgbe nke a gasịrị, ọ dị mkpa ịhapụ ezumike ma ọ dịkarịa ala ọnwa atọ. Ọ bụrụ na i were Metformin ruo ogologo oge, riri ahụ na mbelata na nsonaazụ ahụ nwere ike ịpụta.

Zentiva metformin

A na-eji Metformin zentiva arụ ọrụ na ahụike dịka otu n'ime ọgwụ maka ụdị shuga 2. Taa, ụlọ ọrụ na-emepụta ọgwụ na-emepụta ọtụtụ ọgwụ dị iche iche na-ebelata shuga, metformin zentiva bụ otu n'ime ha.

Otu uru isi ọgwụ a bara bụ na, n’adịghị ka ọgwụ ndị a na - enweta na sulfonylureas, ọ naghị ebute hypoglycemia. A kọwara ihe ngosi a site na eziokwu ahụ bụ na Metformin abụghị ihe mkpali nke insulin na-agba site na mkpụrụ ndụ beta nke pancreatic.

Ntụziaka maka ojiji

Mbadamba ụrọ na-ewere ọnụ. A naghị akwado ya taa ata ma ọ bụ gbutuo mbadamba. A na-agbakọ usoro ọgwụgwọ ahụ kwa ụbọchị iji ọgwụ ahụ, maka ọnwa 1.

Usoro onunu ogwu maka ndi okenye:

• A na-atụ aro ka ịmalite were ya were ọgwụ nke 500 mg, were ọgwụ ịkarị 1.5 g,
• jiri nwayọ, mgbe ụbọchị iri gachara, ọnụọgụ ọgwụ na-abawanye site na 850 mg ugboro abụọ n'ụbọchị ma ọ bụ ruo 1000 mg, yana ọnụọgụ kwa ụbọchị nke 3 g.

N'ọnọdụ ụfọdụ, a na-anabata mgbanwe site na 500 mg gaa 1000 mg ozugbo. Ọ bụ dọkịta na-eme ngụkọta nke usoro ọgwụgwọ na usoro ọgwụgwọ, dabere n'ọnọdụ onye ọrịa.

Innovation na ọrịa shuga - na-a everyụ kwa ụbọchị.

N'oge usoro ọgwụgwọ na Metformin Zentiva, ndị ọrịa buru ibu na-enweta mbelata nke ahụ ya ma ọ bụ mgbatị ya!

Metformin Richter

Ekwesịrị ị were mbadamba Metformin-Richter dum ma ọ bụ ozugbo nri gachara, were obere mmiri washedacha ha. Iji belata nsonaazụ si eriri afọ, a ga-ekewa ihe ị na-eme kwa ụbọchị n'ime usoro 2-3.

N'ihi ịba ụba nke lactic acidosis, a ga-ebelata dose ahụ na nsogbu metabolic siri ike.

Ngwakọta, ịhapụ ụdị

Ọgwụ a dị na mbadamba nkume nke nwere ihe mejupụtara metformin: 500, 850 ma ọ bụ 1000 mg.

Ngwa jikọtara: steeti sodium carboxymethyl, povidone-40, aerosil, stachi ọka, E-572.

Ihe mkpuchi ihe nkiri: Sepifilm-752 (White) Macrogol-6000.

500 mg - okirikiri, convex n'akụkụ abụọ, kpuchie ya na mkpuchi ọcha.

850 mg na 1000 mg bụ nke elongated, convex, na mkpuchi ọcha. N’otu n’ime ihe dị na ọgwụ mgm 500 ahụ, e nwere ihe nkedo nke na-eme ka agbasa ga-agbasa, na nkwadebe 1000 mg ka etinyere ya n’akụkụ abụọ.

Ihe ngwugwu dị na paịlị dị mbadamba 10. Na mkpọ nke kaadiboodu gbara ọkpụrụkpụ - 3/6/9 efere yana nkọwa-ntuziaka.

Ngwongwo na-agwọ ọrịa

Ezubere ọgwụ a maka nchịkwa ọnụ. A na - enye nsonye mmịkọ site na ya isi - metformin. A na-etinye ihe a n’ime otu biguanides - ogige nke nwere hypoglycemic Njirimara nke nwere ike ịhazi ọdịnaya glycemic dị n’ahụ. Ọ dị iche na usoro ndị ọzọ nke sulfonylurea n'ihi na ọ naghị emetụta mkpụrụ ndụ nke agwaetiti nke Langerhans na-emepụta insulin mmiri ọgwụ, yabụ anaghị enye aka na ntinye hypoglycemia.

Mgbe ọ batasịrị n’ime ahụ, ọ na-eme ka nnabata nke insulin na-anabata nnabata ma na-emekwa ka nhazi nke glucose na-arụ ọrụ. Na mgbakwunye, ọ na-egbochi imepụta ihe n’ime imeju site na-egbochi usoro nke glycogenolysis, gluconeogenesis ma gbochie ya itinye ya na ngari nri.

Metformin na - eme ka glucose dị mma, na - enwe mmetụta bara uru na oke cholesterol na - emerụ ahụ ma baa uru. Fọrọ nke nta ọ bụla mmetụta na set nke mmezi pound.

A na-etinye ihe ahụ na ngọngọ diges, a na-etolite uche kachasị n'ime ọbara mgbe awa 2-2.5 gachara. Ọnụego mgbakasị ahụ pụrụ ịda n'ihi nri a na-eri, ebe ọ bụ na a na-eji nwayọọ na-anwụ anwụ ngwa ngwa. Metformin ihe fọrọ nke nta ka ọ bụrụ adịghị anabata protein ndị dị na plasma, mana ọ nwere ike ịgafe sel ọbara ọbara.

Ihe fọrọ nke nta ka ọ bụrụ na ọ dịghị etolite akụrụngwa metabolic, akụrụ ya ga-abụ nke fọrọ obere ka ọ bụrụ otu ụdị.

Mkparịta ụka ọgwụ ọjọọ

Ọnụ ego, 500 mg: (30 pcs.) - 133 rub., (60 PC.) - 139 rub. 850 mg: (30 PC.) - 113 rub., (60 pcs.) - 178 rub. 1000 mg: (30 PC.) -153 rub., (60 PC.) - 210 rub.

Njikwa glycemia na-eji Metformin Zentiva kwesịrị iburu n'uche njirimara nke njikọ yana ọgwụ ndị ọzọ. Ma ọ bụghị ya, n’otu oge usoro ọgwụgwọ nke ihe dị iche iche nwere ike ibute mmeghachi omume a na-enweghị ike ịkọwapụta na ịmalite inwe mmetụta ọjọọ.

Mbadamba ụrọ na-a drinkụ ihe ọ withụ withụ nwere ayodiin nwere nke nwere ayodiin. Ndị na-emepụta na-atụ aro ịkwụsịtụ ojiji nke metformin ụbọchị abụọ tupu nyocha X-ray. Anabatachachi nnabata mgbe usoro usoro a gachara, ka emechara ụbọchị abụọ. Ọ bụrụ na onye ọrịa ahụ na-eleghara ọgwụ contraindications, nsonaazụ nke ọgwụ ndị ahụ ga-abụ arụmọrụ gbasara akụrụngwa, nke ga-eduga na nchịkọta nke metformin na ahụ ma mekwaa ọnọdụ ndụ egwu - lactic acidosis.

Ngwakọta ndị a na-achọghị

Mmanya na-egbu egbu Pnweta ọgwụ megide nzụlite nnukwu ị alcoholụ mmanya na-egbu egbu na-eso akpata nguzobe acidosis. Ọnọdụ egwu na-egosiputa onwe ya nke ukwuu ma ọ bụrụ na agụụ na-agụ onye ọrịa ma ọ bụ daa nri (nri, bu ọnụ) ma ọ bụ nwee nsogbu imeju / akụrụ. Ka ịghara ịkpasu oke nsogbu na ahụike, mgbe ị na-ewere Metformin, ịkwesịrị iwepu mmanya ị ,ụ mmanya na-aba n'anya, ọgwụ na ethanol.

Nchikota nke metformin na ogwu ndi ozo choro ichota akara

• Danazole: ọ bụ ihe na-achọghị ka ikpokọta ya na metformin n'ihi mmetụta hyperglycemic nwere ike ịdị. Ọ bụrụ na ọ gaghị ekwe omume ịkagbu Danazol, ekwesịrị ịlele usoro nke metformin mgbe niile ma gbanwee ya dịka ndị na - egosi shuga si dị.
• Chlorpromazine nwere ike ịbawanye glycemia na nnukwu usoro, na-egbochi ntọhapụ nke insulin.
• GCS na-ebelata nnabata glucose, na-abawanye glycemia, n'ọnọdụ ụfọdụ ọ nwere ike ịkpasu ketosis. N'oge nchịkwa GCS na mgbe akagbuo ha, ịkwesịrị ịgbanwe usoro onunu ogwu nke metformin.
• Diuretics Nlekọta nke nkwonkwo nwere ike ịkpalite lactic acidosis n'ihi mbelata ọrụ ọrụ na mkpokọ.
• Β2-adrenergic agonists site na ime ihe na-anabata ndị na-anabata ihe na-abawanye ọdịnaya glucose ọbara. Ọ dị mkpa ịlele usoro nke metformin mgbe niile ma ọ bụ were insulin dochie ya.
• Ọgwụ na sulfonylurea, insulins na salicylates mgbe gị na ọgwụ Zentiva na-emekọrịta ihe na-ewelie mmetụta hypoglycemic.
• Nifedipine na - akwalite oriri nke metformin ma na - eme ka itinye uche ya na anụ ahụ dịkwuo elu.
• Ọgwụ nke cationic otu, n'ihi eziokwu ahụ bụ site na teliles renal na-ewepụ ha, na-abanye na mpi na metformin ma ya mere na-enwe ike ịkwalite ọdịnaya ya.
• Emebisiri ọrụ nke Metformin Zentiva n'okpuru mmetụta nke phenositins, estrogens (gụnyere dịka akụkụ nke mgbochi mgbochi), ọmịiko, nicotinic acid, BKK, onye na-ahụ maka ọgwụ TB bụ Isoniazid.
• Streme ka ihe omume nke mbadamba nkume nwere metformin nwere ike ịhụta mgbe ejikọtara ya na NSAIDs, MAOI, ọgwụ Oxytetracycline, fibrates, cyclophosphamide, sulfonamides.
• Ọgwụ nwere ike ịkụda nsonaazụ Fenprokumon.

Nsonaazụ

Njikwa nke glycemia site na enyemaka nke ọgwụ Metformin Zentiva nwere ike ibute mmetụta na-adịghị mma n'ụdị nsogbu dị iche iche:

• Ọbara na lymph: hemolytic anaemia.
• Metabolism na nri nri: lactic acidosis, mmetụ nke cyanocobalamin na-arịa ọrịa n'ime ndị ọrịa nwere ọrịa B12 folio-deficiency pathology. Ọzọkwa, ihe na-eme na nephrompathy nke nsogbu n'akụkụ ndị ọrịa enweghi nsogbu anaghị ewepụrụ onwe ha. B12.
• NS: dysgeusia, encephalopathy.
• Ọkụ afọ: ọgbụgbọ, mkpọtụ nke ọgbụgbọ, afọ ọsịsa, mgbu nke afọ, belatara nri iri nri. Mmetụta ndị na-achọghị na-abụkarị na mmalite nke usoro ọgwụgwọ ma mesịa jiri nwayọọ nwayọọ kwụsị mgbe a na-eburu mbadamba. Iji gbochie ha ịpụta, a na-atụ aro ka usoro ubochi kwa ụbọchị ka usoro 2-3 ma drinkụọ ihe ọ drinkụ duringụ n'oge nri. Usoro a ga - ahụ maka ịbanye ọgwụ nwayọ nwayọ na mkpụrụ ndụ ma na - eso mee ka ahụ dịkwuo nro.
• Akpukpo aru na s / c nke dermis: itching, urticaria, erythema, na ufodu ndi oria - mmụba na ncha akpụkpọ ahụ n’anyanwụ anyanwụ na UV
• Imeju: oge ​​ụfọdụ mmụba na ọrụ nke enzymes na-apụ n'anya mgbe ọ kwụsịrị ọrụ ahụ, ịba ọcha n'anya.
• Data nnwale nke ụlọ nyocha: mbelata nke mkpụrụ ndụ TT thyroid na ndị ọrịa nwere hypothyroidism, hypomagnesemia n'ihi afọ ọsịsa.

Metformin analogs

Ọ bụrụ na ọ dị mkpa, ịnwere ike iji ọgwụ nwere ụdị ihe mebere Met Metin, ndị a gụnyere:

• Mpempe Novo.
• Siofor.
• Gliformin.
• Ọrịa.
• Glyminfor.
• Mpempe.
• Glycon.
• Sofamet.
• Metospanin.

N'agbanyeghị ụdị ọgwụ analogue, ọ dị mkpa ịmụ ntuziaka na nkọwa zuru ezu ma mara mmetụta ndị ọ na-akpata.

Iji belata ịdị arọ nke otu ọgwụ agaghị ezu. Iji nweta nsonaazụ a na-ahụ anya, ọ dị mkpa iji echiche gakwute nsogbu ahụ. Iji Metformin na-enye gị ohere ịmalite usoro nke itinye ego na abụba, n'agbanyeghị nke adịghị na nri na mmega ahụ, ọgwụ a agaghị adị irè.

Nyocha ndị mmadụ gbasara metformin:

Metformin zentiva maka oke ibu, nkuzi

Ọ bụrụ na mkpụrụ ndụ ndị a na-eguzogide ọgwụ, ya bụ, insulin insulin, mgbe ahụ ha agaghị enweta glucose site n'ọbara. Ndị na-ahụ maka ọgwụ hypoglycemic, ma e wezụga insulin. Mmeghachi omume anụ ahụ na-adịkarị obere, gụnyere erythema, pruritus, urticaria.

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin salicylates, MAO inhibitors, oxygentetracycline inhibitors nke ACE, yana clofibratomycyclophosphamide, hypoglycemic mmetụta nke metformin nwere ike ịbawanye elu.

Ọ na-agbanwe usoro ọjọọ nke na-ebute oke ibu, insulin na-eguzogide ọgwụ na hyperinsulinism.

Agbanyeghị, enweghị data na nsonazụ metformin na itolite etolite na metformin belata nke ukwuu, yabụ jiri nlezianya na-elele paramita ndị a na ụmụaka ana - agwọ metformin, ọkachasị mgbe ha na - eto eto.

Metformin: ntuziaka maka ojiji ibu

Kedu ihe nwere ike dochie Siofor? Mmetụta shuga na-ebelata ọgwụ a na-ahụ nke ọma ma na-ahụ ya n’ebe ndị ọrịa niile nọ. Mbadamba ihe mkpuchi.

Mgbe ị tabletsụchara mbadamba metformin, ị nwere ike ị alcoholụ mmanya na-eme ihe ike ruo n'ókè ọ fọrọ obere ka ọ bụrụ ozugbo, ọ dịghị mkpa ichere. You nwere ike were usoro ọmụmụ vitamin B12 otu ugboro n’afọ iji gbochie ụkọ nri n’oge usoro ọgwụgwọ na-aga n’ihu na metformin.

Ọnọdụ a etolite na Metformin, nke ebumnuche bụ idobe ọkwa shuga nkịtị na ọrịa shuga. N'ezie, ma e wezụga ikpe mgbe oke ibu na-eso ndị ọrịa shuga. Iji belata nsogbu ọrịa shuga na ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 2 dị oke ibu dịka ọgwụ nke mbụ nwere usoro ọgwụgwọ nri adịghị arụ ọrụ.

Metformin: nyocha nke ifelata

Enwere ike iburu Siofor maka oke ibu Siofor na mbadamba metformin ndị ọzọ maka ibu belata ọ bụghị naanị maka ndị ọrịa nwere ọrịa shuga 2, kamakwa maka ndị nwere ahụike. Nke dị n’elu peeji a, ị gụọla usoro usoro usoro onunu ogwu kwesịrị ịdị iji zere afọ ọsịsa, isi ọkụ, ọgwụ na mmetụta ndị ọzọ.

N'ihi ya, n'ime oge dị mkpirikpi, agbakwunyere m ihe fọrọ nke nta ka ọ bụrụ 20 n'arọ. Kedu ụdị dose kachasị elu kwa ụbọchị? Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha. Zentiva Slovakia Biko mara na ọgwụ mbụ abụghị Siofor, mana Glucophage.

Mbadamba ụrọ Metformin na-aba uru ma na-emebi ahụ ya

"Metformin" bụ ọnya hypoglycemic na-elekọta mmadụ gosipụtara maka iji ya na ọgwụgwọ nke ụdị ọrịa shuga 2 nke ọrịa mellitus.

• Kedu ụdị mpempe akwụkwọ Metformin na mejupụtara?

Ngwakọta kemịkal dị n'ọrụ bụ metformin hydrochloride, ihe dị n'ime ya bụ milligram 500. Ndi ozo bu: talc, povidone K90, na mgbakwunye, crospovidone, ọka ọka, titanium dioxide, magnesium stearate, macrogol 6000.

Metformin ọgwụ ahụ dị na mbadamba ụrọ, ha gbara ya gburugburu n'ụdị yana ọcha. Wepụtara na blisters nke 10 iberibe. A na-ere ọgwụ ndị erere.

• Gịnị bụ usoro Metformin ji arụ ọrụ?

Metformin bụ otu nke biguanides ma nwee ihe ndị a na-eme iji belata ọgwụ chọrọ iji belata ma mee ka ọkwa glucose dị n'ọbara, na-enweghị emetụta insulin nke insulin.

Mbadamba ụrọ Metformin nwere ike ime ka usoro glucose dị elu ma tinye n'ọrụ site na uru anụ ahụ, karịsịa akwara, nke na-eduga n'ịbelata ọkwa nke carbohydrate. Ọ dị mkpa icheta na iji shuga dị mma ga-achọ ka arụ ọrụ zuru oke.

Ọgwụ na-egbochi usoro ndu nke carbohydrates n'ime imeju, nke na-emetụta ọdịnaya nke ọ bụghị naanị glucose, kamakwa triglycerides dị ize ndụ. Normalization nke lipid etoju nwere mmetụta dị mma na usoro nke ọrịa shuga, na-egbochi mmepe nke nsogbu.

Metformin na - enyere aka belata ma meekwa ka ahụ sie onye ahụ ike. N’ezie, nke a anaghị ewepụ mkpa ọ dị ịrapara na nri pụrụ iche nke nwere ntakịrị ume nke carbohydrates na abụba.

Ọgwụ nwere mmetụta nke fibrinolytic, ihe kpatara ya bụ mgbochi nke anụ ahụ plasminogen activates inhibitor. Kwalite n'ọbara nke anụ ahụ na --eme ka mgbochi nke nsogbu vaskụla ụbụrụ na - esokarị ọrịa shuga.

Metformin na-agbasi ike na eriri afọ. Usoro ọgwụgwọ nke ọgwụ ahụ na-etolite awa 2.5 mgbe nchịkwa gasịrị. Ogwu a di otutu aru ma nwekwa ike imubanye aru: aru ara, imeju, na akwara, akwara.

A na-eme mmụcha nke metformin hydrochloride na mmamịrị. Iwepu ọkara ndụ na - eme site na awa 9 ruo 12. Site na ọrịa akụrụ, ihe ngosi a dị mkpa nwere ike ịba ụba.

• Gịnị ka Metformin na-eme, kedụ uru ọ baara ahụ mmadụ?

Nlekọta nke ọgwụ Metformin (shuga) na-akụda shuga (ụdị mbadamba) na-enye ohere iji ọrịa shuga mellitus nke ụdị nke abụọ (ya na arụmọrụ adịghị mma, usoro mmega ahụ, ọkachasị yana yana oke oke ibu).

Ekwesịrị itinye Metformin n'ụdị ọrịa shuga 2 n'ọrịa ndị ọkachamara na nsonaazụ ọmụmụ ụlọ nyocha nke onye ọrịa. Iji iwu akwadoghị nwere ike ibute nsonaazụ dị egwu.

Anaghị anabata ojiji nke Metformin maka ụdị shuga 2 n'ọnọdụ ndị akọwapụtara n'okpuru:

• Nsogbu dị ukwuu na imeju, • ọdịda arụ, • Ime, • Ọrịa, • Ọrịa na-efe efe, • Mkpa ọgwụgwọ ọgwụgwọ, • acid acid,, ị intoụbiga mmanya ókè,

Na mgbakwunye, a naghị eji ngwá ọrụ ahụ maka ọnọdụ hypoxic.

• Gini bu ogwu nke metformin? Etu esi ewere Metformin maka ọrịa shuga.

Usoro ọgwụgwọ dị mma ma dị nchebe na-abụkarị site na milligrams 500 ruo 1 gram nke metformin hydrochloride kwa ụbọchị. N'ọdịnihu, dabere n'ọkwa glucose, ị nwere ike ịhazigharị ọnụọgụ ọgwụ ị medicationụrụ. Usoro kachasị elu kwa ụbọchị bụ 3 grams.

Metformin ọgwụ ahụ, nke anyị gara n'ihu na-ekwu maka ya na ibe a: www.rasteniya-lecarstvennie.ru, ekwesighi etipịa ma ọ bụ rie ata. A na-atụ aro ị takeụ ọgwụ ahụ ugboro abụọ ruo atọ n'ụbọchị, mgbe nri gachara, yana ọkara iko mmiri. Ọgwụgwọ bụ oge ndụ gị niile.

• Nwere Metformin Metubiga oke ókè?

Mgbaàmà bụ: mbelata aru nke aru, afọ ọsịsa, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, na iku ume. Ọgwụ dị ka ndị a: ụlọ ọgwụ ọsịsọ, ọrịa ịba ọcha n'anya, ọgwụgwọ Symptomatic.

• Kedu ihe mmetụta nke metformin?

Mgbe ị na-ewere Metformin, nkọwa ahụ - nkọwa nke agbakọtara na ngwugwu ahụ, na-adọ ndị ọrịa aka ná ntị na ịgwọ ya na ọgwụ ahụ nwere ike sonyere akara ngosipụta. Dịka ọmụmaatụ, ọ nwere ike ịbụ: mgbu afọ, afọ ọsịsa, agụụ riri, ụtọ ọla na ọnụ, obi mgbawa, mmeghachi ahụ nfụkasị, ọgbụgbọ, isi ọwụwa, mgbakwunye, adịghị ike, yana mgbanwe na nyocha ọbara.

Ọnọdụ Hypoglycemic na-esonyere adịghị ike na anya mmiri. Nke a kwesịrị icheta ma ọ bụrụ na a manyere onye ọrịa ịgbaso usoro ọgwụgwọ zuru oke metụtara ojiji nke metformin na ọgwụ ndị ọzọ na-ebelata shuga. Site na iji monotherapy, ihe ndị dị otú ahụ na-akpatakarị ọnọdụ.

• Etu esi edochi metformin?

Metadiene, Siofor 500, Bagomet, Metformin Novartis, Metospanin, Metformin-Teva, Metformin-BMS, Langerine, Metformin-Canon, Sofamet, Nova Met, Gliformin, Formin Pliva, Glucofage ogologo, Metformin hydrochloride, Metfogamma 850, Metfogamma 1000, 1000fo , Metformin MV-Teva, NovoFormin. Siofor 1000, Glycon, Glucofage, Metformin Zentiva, Metformin Richter, Siafor, Glyformin Prolong, Glyminfor, Diaformin OD, Metformin, Metfogamma 500, yana Formmetin.

Ndị ọrịa kwesịrị icheta na ị drugsụ ọgwụ iji belata shuga anaghị ewepu mkpa ịgbaso nri obere carb. Na mgbakwunye, mmega ahụ na mkpa ọ dị ịchekwa glucose mgbe niile dị mkpa. Echefula banyere mkpa ịhapụ àgwà ọjọọ.

Metformin maka oke ibu: etu esi ewere ya, ihe ị ga - atụ ụjọ banyere nyocha + nke ndị felatawo na ndị dọkịta

Na usoro a, ihe na-adọrọ mmasị nke burula ụzọ dị ukwuu n'ịgwọ ọrịa shuga, enwere ike iji ya mee ihe mgbe ụfọdụ n'ụzọ anụ ahụ dị omimi ma na-agụsi ya ike dị ka ọgwụ ịka nká. Metformin maka iwelata ibu: otu esi ewere ya nke ọma, onye nwere ike ịnwale ya, na onye ga - eme nke ọma na - enweghị ya, nyocha nke ndị dọkịta na ndị furu oke site na nzukọ na n'ezie.

Gịnị bụ metformin?

Nke a bụ ọgwụ shuga dị ala nke na-arụ ọrụ na mpụta. Ọ dịghị akpali ahụ mmadụ na-eme ka insulin na-arụ ọrụ ngwa ngwa, mana ọ na-emetụta ọsọ na ike nke metabolism metabolism n’akwara ndị ọzọ na anụ ahụ nke anụ ahụ - na mpụga pancreas.

Ntinye ederede ọsọ ọsọ:

Kedu ihe bụ usoro nke metformin ji arụ ọrụ n'ahụ

Ndepụta nke usoro bụ ihe dị oke mkpa. N'ime nri ọkpọọpụta nke onye nrụpụta, ị nwere ike ịgụ ya na ntuziaka ọ bụla (rịọ maka "metformin ntuziaka maka ojiji").

N'okwu dị mfe, akọwapụtara uru ọgwụ dị na ihe atụ dị n'okpuru.

Usoro edepụtara maka usoro iji mee ihe dabara adaba na ọgwụgwọ nke ọtụtụ ọrịa:

1. Ọrịa shuga,
2. Ọrịa nke nnabata glucose ("ọrịa shuga"),
3. Ibu oke ibu na metabolic syndrome,
4. Cleopolycystic ovary n'ime ụmụ nwanyị.

A na-ejikwa Metformin na ọgwụ egwuregwu na iji gbochie ịka nká.

Ọgwụ na-ebelata glycation protein - otu n'ime isi ihe kpatara sistemu ọnya ụbụrụ. Enwere ndị obodo na-anụ ọkụ n'obi na-eji ọgwụ ahụ eme ka ndị ntorobịa dịkwuo ogologo. Elena Malysheva a ma ama aguputala nyocha ugboro ugboro banyere metformin. Nke a abụghị ikwubiga okwu ókè ma ọ bụ ikwujọ mmadụ, kama ọ bụ nkwubi okwu sayensị ugbu a.

Hyperinsulinism - Nsogbu nke Ndị riri oke

Insulin bu homonụ nke pancreas mepụtara. Ihe dị na ya bụ ihe na - eme ka ụmụ irighiri ihe glucose na sel anyị nọ: “Ndeewo! Anyị maara ibe anyị! Anọ m n'ihe oriri, anyị ga-eri nri ehihie! ”

Hyperinsulinism bụ ọnọdụ a na-efe efe mgbe ọnya na-amịpụta insulin zuru ezu maka iri nri, mana ọ na-anara ọbara nke ọma n'ihi mbelata nke mmetụta nke ndị na-anabata anụ ahụ.

“Anyị amataghị onye ọ bụ - mee ka ịta ahụ dịkwuo nkọ!” - ihe a chọrọ maka nsogbu a na-esochi. Gland na-emezu: enwere insulin karị n'ọbara.

Nke a bụkwa ọnya iji na-abawanye ụba anụ ahụ!

N'ihi na ịba insulin mgbe niile na-akwalite nchekwa abụba: carbohydrates na protein a na-ejikọtaghị na-edozi nke ọma karị.