Augmentin n'ụdị nkwusioru: ntuziaka maka ụmụaka
Ntụ ntụ maka nkwadebe nke nkwusioru maka nchịkwa ọnụ nke ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, nwere njiri mara, mgbe etinyere ya, a na-etisa nkwụchi nke ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọcha.
| 5 ml nke nkwusioru emechara. | |
| amoxicillin (n'ụdị nke amoxicillin trihydrate) | 125 mg |
| clavulanic acid (n'ụdị potassium clavulanate) * | 31,25 mg |
Ndị pụrụ iche: xanthan gum - 12.5 mg, aspartame - 12.5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 150 mg, oroma oroma 1 - 15 mg, oroma oro 2 - 11.25 mg, rasberi rasberi - 22.5 mg, ihe na-adọrọ adọrọ "Molasses na-acha ọcha" - 23.75 mg, silicon dioxide - 125 mg.
11.5 g - karama karama (1) zuru ezu na okpu eji atule ya - ngwugwu nke kaadiboodu.
Ntụ ntụ maka nkwadebe nke nkwusioru maka nchịkwa ọnụ nke ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, nwere njiri mara, mgbe etinyere ya, a na-etisa nkwụchi nke ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọcha.
| 5 ml nke nkwusioru emechara. | |
| amoxicillin (n'ụdị nke amoxicillin trihydrate) | 200 mg |
| clavulanic acid (n'ụdị potassium clavulanate) * | 28.5 mg |
Ndị pụrụ iche: xanthan gum - 12.5 mg, aspartame - 12.5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 79.65 mg, oroma oroma 1 - 15 mg, oroma oro 2 - 11,25 mg, rasberi rasberi - 22.5 mg, Flavour "Molasses" - 23.75 mg, silicon dioxide - ihe ruru 552 mg.
7,7 g - karama karama (1) zuru ezu na okpu eji eme ihe - ngwugwu nke kaadiboodu.
Ntụ ntụ maka nkwadebe nke nkwusioru maka nchịkwa ọnụ nke ihe na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, nwere njiri mara, mgbe etinyere ya, a na-etisa nkwụchi nke ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke ọcha.
| 5 ml nke nkwusioru emechara. | |
| amoxicillin (n'ụdị nke amoxicillin trihydrate) | 400 mg |
| clavulanic acid (n'ụdị potassium clavulanate) * | 57 mg |
Ndị pụrụ iche: xanthan gum - 12.5 mg, aspartame - 12.5 mg, succinic acid - 0.84 mg, colloidal silicon dioxide - 25 mg, hypromellose - 79.65 mg, oroma oroma 1 - 15 mg, oroma oro 2 - 11,25 mg, rasberi rasberi - 22.5 mg, ihe na-adọrọ adọrọ "Molasses na-acha ọcha" - 23.75 mg, silicon dioxide - ruo 900 mg.
12,6 g - karama karama (1) zuru ezu na okpu eji eme ihe - ngwugwu nke kaadiboodu.
* n'ime mmepụta ọgwụ, a na-edobe ọgwụ clavulanate potassium na ngafe 5%.
Omume ọgwụ
Amoxicillin bụ ọgwụ mgbochi ọgwụ nke na-eme ka mmiri dị nro dị n'ọtụtụ ọgụ na -emegide ọtụtụ gram-positive na gram-microorganisms. N'otu oge ahụ, ọgwụ ce-lactamases ga-emerịrị mbibi ahụ, yabụ na ụdị ọrụ ahụ nke amoxicillin anaghị adị na microorganisms nke na-emepụta enzyme a.
Clavulanic acid, ihe β-lactamase inhibitor nke metụtara penisilini, nwere ike ime ka ọtụtụ β-lactamases ndị dị na penisilini na cephalosporin na-eguzogide ọgwụ. Clavulanic acid nwere nrụpụta zuru ezu megide s-lactamases nke plasmid, nke na-ekpebikarị iguzogide nje bacteria, yana ọfụma na-emegide chromosomal ct-lactamases nke ụdị 1, nke clavulanic acid na-egbochi.
Ọnụnọ nke clavulanic acid dị na nkwadebe Augmentin protects na-echebe amoxicillin site na mbibi site na enzymes - β-lactamases, nke na-enye ohere ịgbasa ụdị nje nje nke amoxicillin.
Ihe ndị a bụ ọrụ njikọta nke vitro nke amoxicillin na clavulanic acid.
Nje bacteria na-agbakarị ọgwụ ma ọ bụ ngwakọta nke amoxicillin na clavulanic acid
Aerobes nke dị mma: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, Streptococcus spp. (beta ọzọ hemolytic streptococci) 1,2, Staphylococcus aureus (na-emetụta methicillin) 1, Staphylococcus saprophyticus (na-emetụta methicillin), Staphylococcus spp. (coagulase-adịghị mma, na-emetụta methicillin).
Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Anaerobes dị mma nke Gram: Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.
Anaerobes ihe na-acha ọbara ọbara: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp.
Ndị ọzọ: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Nje nke bu nje nke nwetara ihe ojoo na nchikota amoxicillin na clavulanic acid nwere ike idi
Aerobes Gram-negative: Escherichia coli 1, Klebsiella oxytoca, Klebsiella pneumoniae 1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.
Aerobes dị mma: Corynebacterium spp., Enterococcus faestero, prọonia, Streptococcus 1,2, Virptoans Streptococcus 2.
Nje bacteria na -eche na -echeta njikọta nke amoxicillin na clavulanic acid
Aerobes Gram-negative: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersin
Ndị ọzọ: Chlamydia poniaoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.
1 E gosipụtara ụdị microorganism dị iche iche, arụmọrụ nke akụrụngwa nke ngwakọta nke amoxicillin na clavulanic acid n'ọmụmụ nyocha.
2 inszọ ụdị nje dị iche iche anaghị emepụta β-lactamases. Ihe mmetụta uche na amoxicillin monotherapy na-atụ aro inwe uche yiri nke ahụ na nchikota nke amoxicillin na clavulanic acid.
Mlọ ọgwụ
Ngwa ọrụ abụọ a na-arụ ọrụ nke Augmentin ®, amoxicillin na clavulanic acid, na-agbakarị ngwa ngwa ma zuo oke na eriri afọ mgbe nchịkwa ọnụ gasịrị. Mwepu nke ihe ndi ahu di nma kachasi nma ma oburu ị takinguru ogwu na mmalite nri.
Augmentin ® 125 mg / 31.25 mg kwa ntụ ọka nkwupụta 5 ml
A na-egosi usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo ahụike dị afọ 2-12 afọ na afọ efu weere 40 mg / 10 mg / n'arọ ahụ / ụbọchị nke ọgwụ Augmentin ®, ntụ ntụ maka nkwusioru maka nchịkwa na usoro 3 site n'ọnụ, 125 mg / 31.25 mg na 5 ml (156.25 mg).
Mpempe ọgwụ pharmacokinetic nke bụ isi
| Nkwadebe | Dose (mg / n'arọ) | C max (mg / l) | T max (h) | Auc (mg × h / l) | T 1/2 (h) |
| Amoxicillin | |||||
| Augmentin ® 125 mg / 31.25 mg kwa 5 ml | 40 | 7.3±1.7 | 2.1 (1.2-3) | 18.6±2.6 | 1±0.33 |
| Clavulanic acid | |||||
| Augmentin ® 125 mg / 31.25 mg kwa 5 ml | 10 | 2.7±1.6 | 1.6 (1-2) | 5.5±3.1 | 1.6 (1-2) |
Augmentin ® 200 mg / 28.5 mg na ntụ ntụ nkwụchi 5 ml
E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo nwere ahụike dị afọ 2-12 afọ na afọ efu weere Augmentin ®, ntụ ntụ maka nkwụsị ọnụ, 200 mg / 28.5 mg na 5 ml (228.5 mg) na usoro nke 45 mg / 6.4 mg / kg / ụbọchị, kewara abụọ.
Mpempe ọgwụ pharmacokinetic nke bụ isi
| Ihe eji arụ ọrụ | C max (mg / l) | T max (h) | AUC (mg × h / l) | T 1/2 (h) |
| Amoxicillin | 11.99±3.28 | 1 (1-2) | 35.2±5 | 1.22±0.28 |
| Clavulanic acid | 5.49±2.71 | 1 (1-2) | 13.26±5.88 | 0.99±0.14 |
Augmentin ® 400 mg / 57 mg ọgwụ ntụ ntụ na 5 ml
E gosipụtara usoro ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid na ọmụmụ dị iche iche n'okpuru, mgbe ndị ọrụ afọ ofufo nwere ahụike were otu ọgwụ Augmentin ®, ntụ ntụ maka nkwụsị ọnụ, 400 mg / 57 mg na 5 ml (457 mg).
Mpempe ọgwụ pharmacokinetic nke bụ isi
| Ihe eji arụ ọrụ | C max (mg / l) | T max (h) | AUC (mg × h / l) |
| Amoxicillin | 6.94±1.24 | 1.13 (0.75-1.75) | 17.29±2.28 |
| Clavulanic acid | 1.1±0.42 | 1 (0.5-1.25) | 2.34±0.94 |
Dị ka ọ dị na ochichi iv nke ngwakọta nke amoxicillin na clavulanic acid, a na-ahụkarị ọgwụ amoxicillin na clavulanic acid na akụkụ ahụ na akwara dị iche iche, ọnya dị n'etiti (akụkụ nke eriri afọ, adipose, ọkpụkpụ na akwara anụ ahụ, ọnya ọgbụgba na peritoneal, akpụkpọ ahụ, bele, na mwepụ ụkwara). )
Amoxicillin na clavulanic acid nwere ogo na-esighi ike nke na-ejikọ protein protein. Nnyocha e mere egosiwo na ihe dị ka 25% nke ngụkọta nke clavulanic acid na 18% nke amoxicillin na-ejikọ na protein plasma ọbara.
Na omumu ihe omumu, ahutara ihe mejuputara ọgwụ ahu Augmentin ®.
Amoxicillin, dị ka ọtụtụ penisiliniins, na-abanye n'ime mmiri ara. Achọpụtakwala mpaghara nke clavulanic acid na mmiri ara. Ewezuga na enwere ike ịmịnye mmụọ, mmepe nke afọ ọsịsa na candidiasis nke akpụkpọ ahụ mucous, enweghị mmetụta ọjọọ ndị ọzọ nke amoxicillin na clavulanic acid na ahụike nke ụmụaka na-enye ara. Ihe omumu banyere oru omumu n’ime anumanu gosiputara na amoxicillin na clavulanic acid na –ebute ihe mgbochi n’ime ala, n’enweghi ihe ojoo n’enye nsogbu n’aru nwa ebu n’afọ.
10-25% nke ọgwụ mbu nke amoxicillin na-apụ n’arụ n’ụdị metabolite na-adịghị arụ ọrụ (penisilloic acid). Clavulanic acid bụ metabolized n'ụba ruo 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid na 1-amino-4-hydroxy-butan-2-otu ma kpụrụ ya na akụrụ site na ngọngọ diges, yana ikuku kubie ume n'ụdị carbon dioxide.
Dị ka ọgwụ penicillins ndị ọzọ, amoxicillin na-apụkarị site na akụrụ, ebe a na-ahụ ọgwụ clavulanic acid site na usoro gbasara akụrụ na extrarenal. Ihe dị ka 60-70% nke amoxicillin na ihe dị ka 40-65% nke clavulanic acid bụ nke akụrụ na-agbanweghi agbanwe n’ime awa 6 mbụ mgbe ha nwesịrị 1 mbadamba 250 mg / 125 mg ma ọ bụ mbadamba 500 nke 500 mg / 125 mg.
Na-egosi Augmentin ®
Nje virus nke bakteria na-akpata:
- Ọrịa nke akụkụ okuku ume na elu akụkụ akụkụ ENT (dịka ọmụmaatụ, ụkwara ume ọkụ ugboro ugboro, sinusitis, otitis media), nke ihe na-ebutekarị bụ Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogenes,
- Ọrịa dị ala nke akụkụ okuku ume na akwara: oke iwe nke bronchitis na-adịghị ala ala, ọnya ụkwara ume ọkụ na bronchopneumonia, nke na-akpatakarị ọrịa okpokoro akpịrị, Haemophilus influenzae * na Moraxella catarrhalis *,
- Ọrịa urinary na-efe efe: cystitis, urethritis, pyelonephritis, ọrịa nke akụkụ ahụ nwanyị, nke na-ebutekarị site na ụdị nke ezinụlọ Enterobacteriaceae (ọkachasị nke Escherichia coli *), staphylococcus saprophyticus na ụdị ụdị mkpụrụ ndụ Enterococcus,
- gonorrhoea nke Neisseria gonorrhoeae kpatara, *
- Ọrịa nke anụ ahụ na anụ ahụ dị nro, nke Staphylococcus aureus * na-ebutekarị, Symptococcus pyogenes na ụdị mkpụrụ ndụ ihe nketa Bactero> * representativesfọdụ ndị nnọchite nke ụdị a nke microorganisms na-emepụta β-lactamase, nke na-eme ka ha bụrụ ndị na-enweghị mmetụta na amoxicillin.
Ọrịa Augmentin be nwere ike ịgwọ ọrịa ndị microorganisms na-emetụta amoxicillin, ebe ọ bụ na amoxicillin bụ otu n'ime ihe ndị dị na ya.
Augmentin ® ka egosiri maka ọgwụgwọ nke ọrịa nje jikọtara nke microorganisms nke nwere amoxicillin, yana microorganisms na-emepụta β-lactamase, na-emetụta nchikota nke amoxicillin na clavulanic acid.
Ọkpụkpọ nke nje bacteria na nchikota amoxicillin na clavulanic acid dịgasị iche dabere na mpaghara na oge. N'ebe enwere ike, ekwesiri iburu n'uche ọgụgụ data mpaghara. Ọ bụrụ na ọ dị mkpa, a ga-anakọta ma nyocha microbiological maka ịchọpụta ihe banyere nje.
Koodu ICD-10| Koodu ICD-10 | Ngosipụta |
| A54 | Ọrịa Gonococcal |
| H66 | Mgbasa ozi oturu na nke ekwesighi ekwenye ekwenye |
| J01 | Ọkpụkpụ sinusitis |
| J02 | Nnukwu pharyngitis |
| J03 | Nnukwu oria |
| J04 | Ọrịa na-arịa nnukwu ọrịa laryngitis na tracheitis |
| J15 | Nje na-efe efe na-efe efe, ọ bụghị ebe ndị ọzọ |
| J20 | Nnukwu akwara |
| J31 | Ọrịa rhinitis na-egbu egbu, nasopharyngitis na pharyngitis |
| J32 | Ọrịa sinusitis na-adịghị ala ala |
| J35.0 | Ọrịa na-adịghị ala ala |
| J37 | Ọrịa na-adịghị ala ala na laryngotracheitis |
| J42 | Ọrịa na-adịghị ala ala, akọpụtaghị ya |
| L01 | Mmetụta impetigo |
| L02 | Ọkpụkpụ anụ, obụpde na carbuncle |
| L03 | Flegmon |
| L08.0 | Pyoderma |
| M00 | Ọrịa ogbu na nkwonkwo |
| M86 | Osteomyelitis |
| N10 | Nnukwu akwara tubulointerstitial nephritis (nnukwu pyelonephritis) |
| N11 | Ọrịa nephritis na-adịghị ala ala (pyelonephritis na-adịghị ala ala) |
| N30 | Cystitis |
| N34 | Ọrịa urethritis na urethral syndrome |
| N41 | Ọrịa na-efe efe nke prostate |
| N70 | Ọrịa salpesitis na oophoritis |
| N71 | Ọrịa inflammatory nke akpanwa, ewezuga maka cervix (gụnyere endometritis, myometritis, metritis, pyometra, uterine abscess) |
| N72 | Ọrịa cervical na-efe efe (gụnyere cervicitis, endocervicitis, exocervicitis) |
| T79.3 | Ọrịa ọnya na-akpata ọnya mgbe ochie gasịrị, ọ bụghị ebe ọzọ nkewa |
Usoro usoro onunu ogwu
A na-ewere ọgwụ ọnụ.
A na-edobe usoro usoro onunu ogwu n'otu oge dabere na afọ, oke ahụ, ọrụ akụrụ nke onye ọrịa, yana ogo ọrịa ahụ.
Maka nnabata kachasị mma na mbelata mmetụta ndị ọ ga - ekwe omume ga-esite na nri mgbari nri, a na-atụ aro Augmentin ® ka ị malite nri.
Obere oge nke ọgwụ mgbochi bụ ụbọchị 5.
Ọgwụ ekwesịghị ịga n’ihu karịa ụbọchị iri na anọ na-enweghị nyocha banyere ọnọdụ ụlọ ọgwụ.
Ọ bụrụ na ọ dị mkpa, ọ ga-ekwe omume duziri ọgwụ (na mmalite ọgwụgwọ, parenteral management of the ọgwụ with sochiri transition to oral management).
Ndị okenye na ụmụaka karịrị afọ 12 ma ọ bụ na-eru 40 n'arọ ma ọ bụ karịa
Ọ na-atụ aro ka iji ụdị ọgwụ on ọzọ nke Augmentin ® ma ọ bụ nkwusioru ya na amoxicillin na clavulanic acid 7: 1 (400 mg / 57 mg na 5 ml).
Agedmụaka dị n’agbata ọnwa atọ ruo afọ iri na abụọ n’arụ ahụ́ ya erughị 40 n'arọ
A na-eme ngụkọta oge dabere na afọ na oke ahụ, nke egosipụtara na mg / kg body body / day (ịgbakọ dịka amoxicillin) ma ọ bụ na ml nke nkwusioru.
Otutu nke iwere ihe na-anakpo 125 mg / 31.25 mg na 5 ml bụ ugboro 3 / ụbọchị kwa awa asatọ.
Otutu nke nkwusioru 200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml - 2 ugboro / ụbọchị kwa awa 12 ọ bụla.
Usoro usoro usoro onunu ogwu a ka akwadoro ka ana egosiputa ya na oge oru ya na tebulu di n'okpuru.
Tebụl Augmentin s usoro onunu ogwu (onodu ogwu maka amoxicillin)
| Otutu ntinye - 3 ugboro / ubochi Nkwụsị 4: 1 (125 mg / 31.25 mg na 5 ml) | Otutu maka nnabata - ugboro abụọ / ụbọchị Nkwụsị 7: 1 (200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml) | |
| Doses dị ala | 20 mg / n'arọ / ụbọchị | 25 mg / n'arọ / ụbọchị |
| Akwa doses | 40 mg / n'arọ / ụbọchị | 45 mg / n'arọ / ụbọchị |
A na-eji ọgwụ Augmentin Low dị ala iji gwọọ ọrịa nke anụ ahụ na anụ ahụ dị nro, yana tonsillitis ugboro ugboro.
A na-eji ọtụtụ ọgwụ Augmentin to agwọ ọrịa dị ka otitis media, sinusitis, tract akụkụ okuku ume na ọrịa urinary, na ọkpụkpụ na nkwonkwo.
Enwe data ezughi oke nke ụlọ ọgwụ iji kwado ọgwụ ojiji nke Augmentin ® na nha karịa 40 mg / kg / ụbọchị n'ime usoro atọ kewara (4: 1 nkwusi) na 45 mg / kg / ụbọchị na usoro 2 kewara (nkwusioru 7: 1) ezughi oke nke nyocha ụlọ ọgwụ iji kwado iji jupụta na ụmụaka na-erubeghị afọ abụọ.
Umuaka site na omumu rue onwa ato
N'ihi ezumike nke akụrụ ahụ, ọgwụ a tụrụ aro ya nke Augmentin ® (ngụkọta maka amoxicillin) bụ mg mg 30 / kg / ụbọchị n'ime usoro 2 nke 4: 1.
Ojiji nke mmachi 7: 1 (200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml) bụ contraindicated na onu ogugu a.
Umu aka amuzu
Enweghị ntuziaka maka usoro usoro usoro onunu ogwu.
Ndị okenye na-arịa ọrịa
O ghaghi imeghari udiri ogwu a. N'ime ndị ọrịa nwere nsogbu gbasara akwara nwere nsogbu, ha kwesịrị idozigharị ya dịka ndị a maka ndị okenye nwere ọrụ mgbazi.
Ndị ọrịa nwere ọrụ mgbazinye nsogbu
Imeghari usoro a dabere na oke ọgwụ a tụrụ aro ya na amoxicillin ma a na-eburu n'uche n'uche ụkpụrụ QC.
| QC | Nkwusi 4: 1 (125 mg / 31.25 mg na 5 ml) |
| > 30 ml / min | Enweghị mmezi usoro onunu ogwu achọrọ |
| 10-30 ml / min | 15 mg / 3.75 mg / kg ugboro 2 / ụbọchị, oke kachasị bụ 500 mg / 125 mg 2 ugboro / ụbọchị |
| ndị ọrịa nwere CC> 30 ml / min, na ntinye ọ̀gaghị achọrọ. N'ọnọdụ ka ukwuu, ọ bụrụ na ọ ga-ekwe omume, a ga-ahọrọ usoro ọgwụgwọ nke ihe na-ahụ maka ọrịa nwa oge. Ọrịa ịba ọcha n'anya Usoro akwadoro usoro ọgwụgwọ bụ 15 mg / 3.75 mg / kg 1 oge / ụbọchị. Tupu oge mmegharị ahụ, a ga-enyekwu otu 15 mg / 3.75 mg / kg. Iji weghachite mkpokọta ihe ndị nọ n'ọrụ ọgwụ ọgwụ Augmentin ® n'ọbara, a ga-enyerịị usoro nke abụọ nke 15 mg / 3.75 mg / kg mgbe emume hapatialysis gasịrị. Ndị ọrịa nwere ọria imeju A na- eji nlezianya na-agwọ ọgwụgwọ; a na-enyocha ọrụ imeju. Enweghi data zuru oke iji dozie usoro usoro onunu ogwu di na ndi otu a. Iwu maka nkwadebe nke nkwusioru A kwadebere nkwusioru ya ozugbo tupu ojiji izizi. Nkwusioru (125 mg / 31.25 mg na 5 ml): gbakwunye ihe dị ka 60 ml nke mmiri esiwo n ’ime ụlọ okpomọkụ ka karama ntụ, wee jiri karama mechie karama ahụ ma maa jijiji ruo mgbe ntụ ọka ahụ kpamkpam, kwe ka karama ahụ guzoro ruo minit 5 iji hụ na o zuru. ozuzu. Tinye mmiri n’ime akara n’ime karama ahụ ma gbanye karama ahụ ọzọ. Na mkpokọta, a chọrọ ihe dị ka 92 ml mmiri iji kwadebe nkwusioru. Nkwusioru (200 mg / 28.5 mg na 5 ml ma ọ bụ 400 mg / 57 mg na 5 ml): gbakwunye ihe dị ka 40 ml nke mmiri sie mmiri mee ka mmiri ahụ banye na karama ntụ, wee mechie karama ahụ na mkpuchi ma maa jijiji ruo mgbe ntụ ọka ahụ gbazere kpamkpam, nye ya. kwusi vial ahụ maka minit 5 iji hụ na ngwakọta zuru ezu. Tinye mmiri n’ime akara n’ime karama ahụ ma gbanye karama ahụ ọzọ. Na mkpokọta, a chọrọ ihe dị ka 64 ml mmiri iji kwadebe nkwusioru. Maka ụmụaka na-erubeghị afọ abụọ, a pụrụ iji mmiri gwọọ ntụtụ nke ọgwụ mgbochi Augmentin Aug na nke 1: 1. Ekwesịrị imebi karama ahụ nke ọma tupu ojiji ọ bụla. Maka ịsingụ ọgwụ ọ accurateụ accurateụ ziri ezi, a ga-eji okpu eji atụ ahụ, nke a ga-eji mmiri wee saa ya nke ọma. Mgbe dilution, ekwesịrị ịchekwa nkwụsị ahụ ihe na-erughị ụbọchị 7 na friji, mana ọ bụghị kpọnwụrụ. Mmetụta akụkụEdeputara ihe ojoo ndi a dị n’okpuru dị ka mmebi nke akụkụ ahụ na akụrụngwa na ugboro ole nke ihe omume. A na-ekpebi ugboro ole a na-ahụkarị dịka nke a: ọtụtụ mgbe (≥1 / 10), ọtụtụ mgbe (≥1 / 100, Ọrịa na parasitic): mgbe mgbe - candidiasis nke akpụkpọ ahụ na akpụkpọ anụ mucous. Site na sistemu hemopoietic: adịkarịghị - enwere ike iweghachi leukopenia (gụnyere neutropenia) na ndọghachi azụ thrombocytopenia, ọ dịkarịghị - enwere ike iweghachite agranulocytosis na mgbake ọbara hemolytic, ịgbatị oge prothrombin na oge ọbara ọgbụgba, anaemia, eosinophilia, thrombocytosis. Site na usoro ahụ ji alụso ọrịa ọgụ: ọ dịkarịsịrị - angioedema, mmeghachi omume anaphylactic, ọrịa nke metụtara ọrịa ọbara, vasculitis nfụkasị. Site na sistemụ ụjọ: obere oge - ọgbụgba, isi ọwụwa, ọ na - adịkarịghị - enwere ike iweghachite hyperactivity, nkwarụ (ụbụrụ nwere ike ịdakwasị ndị ọrịa nwere nsogbu gbasara akụrụ, yana ndị na - anata oke ọgwụ ahụ), nsogbu ehighị ụra, oke iwe, nchekasị, mgbanwe omume . Site na usoro nri: ndi okenye: otutu mgbe - afọ ọsịsa, mgbe mgbe - ọgbụgbọ, ọgbụgbọ, ụmụaka - mgbe mgbe - afọ ọsịsa, ọgbụgbọ, ọgbụgbọ, ọnụọgụ mmadụ niile: ọgbụgbọ bụ ihe a na-ahụkarị mgbe ị na-a doụ ọgwụ ọjọọ. Ọ bụrụ na mgbe ịmalite ị drugụ ọgwụ ahụ enwere mmeghachi omume na-adịghị mma site na eriri afọ, a ga-ewepụ ha ma ọ bụrụ na ị theụọ ọgwụ ahụ na mbido nri. Na - adịghị ala ala - ọgba aghara nri, ọ na - esikarị - mgbochi ọnya nje na - akpata nje site na ị pụ ọgwụ nje (gụnyere pseudomembranous colitis na hemorrhagic colitis), asịrị ntutu ojii, gastritis, stomatitis. N’aka ụmụaka, mgbe etinyere nkwusioru ahụ, ọ na-abụkarị nke na-achọpụta ịchọpụta elu ala nke enamel ezé. N'akụkụ imeju na ọnya biliary: na-adịghị ala ala - mmụba dị ala na ọrụ nke ACT na / ma ọ bụ ALT (nke a hụrụ na ndị ọrịa na-anata ọgwụgwọ ọgwụ mgbochi beta-lactam, mana amabeghị mkpa ọ dị banyere ya), adịkarịghị - ịba ọcha n'anya na cholestatic jaundice (ihe ịtụnanya ndị a ka a chọpụtara n'oge ọgwụgwọ na ndị ọzọ penisiliniins na cephalosporins), mmụba na mkpokọta nke bilirubin na alkaline phosphatase. A hụrụ ihe ojoo sitere na imeju bụ ọkachasị ndị nwoke na ndị ọrịa nwere ike jikọta ya na ọgwụgwọ ogologo oge. Ọ bụghị obere ụmụaka ka a hụrụ ihe ọjọọ ndị a. Ihe iriba ama na akara a edepụtara na - emekarị ma ọ bụ ozugbo ngwụcha ọgwụgwọ ahụ, na agbanyeghị, enwere ike ha apụta ọtụtụ izu mgbe emechara ọgwụgwọ ahụ. A na - agbanwegharị ihe ọghọm. Ihe ojoo sitere na imeju nwere ike bụrụ ihe siri ike, n'ọnọdụ ndị a na-adịghị ahụkebe, enwere akụkọ banyere nsonaazụ na-egbu egbu. N'ihe fọrọ nke nta ka ọ bụrụ n'ọnọdụ niile, ndị a bụ ndị nwere nnukwu ọnụọgụ na-arịa ọrịa ma ọ bụ ndị na-anata ọgwụ hepatotoxic n'otu oge. Site na anụ ahụ na akwara dị n'okpuru ala: adịghị ala ala - ọnya, itching, urticaria, adịkarịghị - erythema multiforme, nke dịkarịsịrị ike - Stevens-Johnson syndrome, toxic epidermal necrolysis, bulf exfoliative dermatitis, nnukwu exanthematous pustulosis. Site na sistemụ urinary: ọ dịkarịsịrị ike - nephritis interstitial, crystalluria, hematuria. Ihe ngbanwe
Ihe mgbochi: arụ ọrụ imeju. Ime na lactationN'ime omumu banyere oru omumu na anumanu, onu na ochichi nke Augmentin cause emeghi teratogenic. N'ime otu nnyocha ụmụ nwanyị nwere membranes akatabeghị aka, achọpụtara na ọgwụ ọgwụ prophylactic nwere ike ịnwe n'ihe egwu dịkwuo elu nke necrotizing enterocolitis n'ime ụmụ amụrụ ọhụrụ. Dịka ọgwụ niile, a naghị atụ aro Augmentin use maka oge a dị ime, ọ gwụla ma uru a tụrụ anya na nne ga-akarị ike nwa ebu n’afọ. Enwere ike iji ọgwụ Augmentin ® mee ihe n’oge a na-enye nwa ara. Na ewezuga ohere nke ịrịa afọ ọsịsa ma ọ bụ candidiasis nke akpụkpọ ahụ mucous nke ọnụ na-esonye na nbanye n'ime mmiri ara ara nke ọnụọgụ ọgwụ na-arụ ọrụ nke ọgwụ ahụ, enweghị mmetụta ọjọọ ndị ọzọ a hụrụ na ụmụ a na-enye ụmụ ara. N'ọnọdụ mmetụta ọjọọ na ụmụaka ndị na-enye nwa ara, ọ dị mkpa ịkwụsị ị -ụ ara. Ntụziaka pụrụ icheTupu ịmalite ọgwụgwọ na Augmentin ®, ọ dị mkpa ịnakọta akụkọ banyere ahụike zuru ezu gbasara mmerụ ahụ gara aga banyere penicillins, cephalosporins ma ọ bụ ihe ndị ọzọ na-akpata mmeghachi omume nfụkasị n'ime onye ọrịa. A kọwara mmeghachi omume dị njọ, na mgbe ụfọdụ ọnwụ, hypersensitivity mmeghachi omume (anaphylactic reactions) na penisilini. Ihe ọghọm nke mmeghachi omume dị otú a bụ nke kachasị elu na ndị ọrịa nwere akụkọ banyere hypersensitivity hypersensitivity penicillins. Maka mmeghachi omume nfụkasị ahụ, ọ dị mkpa ịkwụsị ọgwụgwọ na Augmentin ® wee malite usoro ọgwụgwọ ọzọ kwesịrị ekwesị. N'ihe banyere nzaghachi hypersensitivity siri ike, e kwesịrị inye epinephrine ozugbo. Oxygen therapy, ochichi nke GCS na inye nke patway ikuku, gụnyere intubation, nwekwara ike choro. Ọ bụrụ na inyo enyo na mononucleosis na-efe efe, ekwesighi iji Augmentin ®, ebe ọ bụ na ndị ọrịa nwere ọrịa a, amoxicillin nwere ike ibute ọnya akpụkpọ ahụ, nke na-agbagha nchọpụta nke ọrịa ahụ. Ọgwụ ogologo oge na Augmentin ® na-eduga mgbe ụfọdụ ịmụba ụmụ irighiri ihe na-adịghị mma. Na mkpokọta, Augmentin ® na-anabata nke ọma ma nwee agwa ọjọọ nwere ụdị penicillins niile. N'oge ọgwụgwọ ogologo oge na Augmentin ®, a na-atụ aro ka inyocha ọrụ akụrụ, imeju na usoro hematopoiesis n'oge oge. A kọwara ọrịa nke pseudomembranous colitis mgbe ị na-a antibioticsụ ọgwụ nje, n ’ụzọ nke ya nwere ike ịdị iche site na obere gaa na-eyi ndụ egwu. Ya mere, ọ dị mkpa ịtụle ohere ịnwe pseudomembranous colitis na ndị ọrịa nwere afọ ọsịsa n'oge ma ọ bụ mgbe ejiri ọgwụ nje. Ọ bụrụ na afọ ọsịsa na-adịte aka ma ọ bụ sie ike ma ọ bụ ọrịa ahụ na-enwe afọ, a ga-akwụsị ọgwụgwọ ozugbo wee nyochaa onye ọrịa ahụ. N'ime ndị ọrịa na-anakọta ngwakọta nke amoxicillin na clavulanic acid yana anticoagulants na-apụtakarị (ọnụ), n'ọnọdụ dị ụkọ, mmụba na oge prothrombin (MHO mụbara). Site na ntinye njikọta nke anticoagulants na-apụtachaghị ọnụ (n'ọnụ) yana ngwakọta nke amoxicillin na clavulanic acid, nlebara anya nke ihe ndị dị mkpa dị mkpa. Iji nọgide na-enwe mmetụta ọgwụ anticoagulants chọrọ, a ga-achọ ndozigha dose. N'ime ndị ọrịa nwere nsogbu gbasara akwara nwere nsogbu, ọgwụ Augmentin ® kwesịrị belata ya. N'ime ndị ọrịa nwere ọrịa diuresis, ọrịa kristal na-adịkarị obere, ọ kachasị na usoro ọgwụgwọ oge. Site na ntinye nke amoxicillin na oke onunu ogwu, a na-atụ aro ka ị ofụọ mmiri zuru ezu ma dokwaa ọnọdụ zuru oke iji belata ohere ịkpụpụta kristalillin kristal. Mgbe ị na-ewere Augmentin ® n'ime, a na-achọpụta ọdịnaya dị elu nke amoxicillin na mmamịrị, nke nwere ike ibute nsonaazụ ụgha na mkpebi mkpebi nke glucose na mmamịrị (dịka ọmụmaatụ, nnwale Benedict, nnwale na-agba ọkụ). N'okwu a, a na-atụ aro iji usoro glucose oxidant maka ikpebi mkpokọ glucose na mmamịrị. Clavulanic acid nwere ike ime ka ejikọghị ọnụ nke G nke immunoglobulin na albumin na mkpokọ erythrocyte, na-eduga na nsonaazụ ụgha nke ule Coombs. Ilekọta ahụike anya na-enyere gị aka ịsachapụta eze n ’ị takingụ ọgwụ a, ebe ọ bụ na ichi ezé ezị gị. Iji ihe ojoo na ọgwụ Achọpụtaghị ị dependụ ọgwụ, ọgwụ riri ahụ na mmeghachi omume anụ ahụ metụtara iji ọgwụ Augmentin ®. Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa Ebe ọgwụ ahụ nwere ike ibute ọgbụgba, ọ dị mkpa ịdọ ndị ọrịa aka na ntị banyere ị ga-akpachara anya mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ọrụ igwe na-akpụ akpụ. Dodoụbiga ya ókèMgbaàmà: mgbaàmà eriri afọ na enweghị mmiri elektrik na - eleghara anya. A kọwara amoxicillin crystalluria, n'ọnọdụ ụfọdụ na-eduga na mmepe nke ọdịda akwara. Ọnọdụ nwere ike ịdakwasị ndị ọrịa nwere nsogbu gbasara akụrụ, yana ndị na-anata oke ọgwụ. Ọgwụgwọ: mgbaàmà eriri afọ - ọgwụgwọ ọrịa, na-elezi anya na nhazi nke mmiri mmiri elektrolyte. Bụrụ na ị anụbiga ihe ọseụ ,ụ, enwere ike wepu amoxicillin na clavulanic acid n'ọbara ọbara site na hemodialysis. Nsonaazụ nke ihe ọmụmụ a na-aga n'ihu nke emere ụmụaka 51 n'ime ebe a na-egbu egbu gosiri na nchịkwa nke amoxicillin na nha erughị 250 mg / n'arọ anaghị eduga mgbaàmà dị egwu ma ọ chọghị lavage gastric. Usoro ahịa ọgwụ ahịaE wepụtara ya na ndenye ọgwụ. Ego ole bụ nkwụsịtụ Augmentin? Ọnụego ọnụ ahịa dị n'ụlọ ahịa ọgwụ dị na:
Mkparịta ụka ọgwụ ọjọọA naghị atụ aro iji ọgwụ Augmentin ® na probenecid n'otu oge. Probenecid na-ebelata mmiri mmiri nke tubular nke amoxicillin, yabụ, iji ọgwụ ahụ eme ihe n'otu oge Augmentin ® na probenecide nwere ike ibute mmụba na nnọgide n'ọbara nke amoxicillin, mana ọbụghị clavulanic acid. Ojiji allopurinol na amoxicillin nwere ike ime ka ihe nwetakwuo mmetuta akpụkpọ ahụ. Ugbu a, enweghi data na akwụkwọ a na-eme n'otu oge nke ngwakọta nke amoxicillin na clavulanic acid na allopurinol. Penicillins nwere ike belata mkpochapụ nke methotrexate site na ahụ site na igbochi mmiri nzuzo nke tubular ya, yabụ, iji ọgwụ ahụ eme ihe n'otu oge Augmentin ® na methotrexate nwere ike ịbawanye nsí nke methotrexate. Dị ka ọgwụ ndị ọzọ na-egbochi nje ihe, nkwadebe Augmentin can nwere ike imetụta microflora eriri afọ, na-eduga n'ịbelata nnabata estrogen site na eriri afọ yana mbelata ịdị irè nke ọgwụ mgbochi ọnụ. Akwukwo a na - akọwa okwu banyere obere mmụba na MHO n'ime ndị ọrịa yana jikọtara ọnụ nke acenocumarol ma ọ bụ warfarin na amoxicillin. Ọ bụrụ na ọ dị mkpa iji ọgwụ anticoagulants dee n'otu oge Augmentin ®, ekwesịrị ilebara oge prothrombin ma ọ bụ MHO anya mgbe ị na-edezi ma ọ bụ kagbuo Augmentin ®, ịchọrọ ịgbanwe mmezi nke ọgwụ anticoagulants maka nchịkwa ọnụ. N'ime ndị ọrịa na-anata ọgwụ mocopetolate mofetil, mgbe ịmalitere njikọta nke amoxicillin na clavulanic acid, mbelata nke mkpokọta metabolite na-arụ ọrụ, mycophenolic acid, tupu ị doseụ ọgwụ ọzọ nke ọgwụ ahụ ihe dị ka 50%. Mgbanwe ndị a na mkpofu enweghị ike igosipụta mgbanwe niile na mkpughe nke mycophenolic acid. Mwepụta wepụtara ya na ihe mebereỌgwụ a mejupụtara:
Odi di iche-iche:
Ntụ ntụ ezubere maka nrụpụta nke mmachi ahụ dị na UK (SmithKline Beecham Pharmaceuticals). Mmetụta ọgwụAchọpụtara mmetụta nje ahụ. Ọgwụ a na-arụ ọrụ na aerobic / anaerobic gram-positive, aerobic gram-microorganisms. Ọ dị irè nke ukwuu megide ụdị ndị nwere ike ịmịpụta beta-lactamase. N'okpuru mmetụta nke clavulanic acid, a na-eme ka nguzogide nke amoxicillin nwee mmetụta nke ihe dịka beta-lactamase. N'okwu a, enwere mmụba nke mmetụta nke ihe a. Ọgwụ na-arụ ọrụ megide:
Mgbe ị na-edepụtara nwata ọgwụ, dọkịta kwesịrị ịgbakọ ego ole achọrọ maka nkwusioru ya. Ihe ngosi maka ojijiEdere Augmentin maka nje ndị na-akpata nje na-akpata microorganisms nke na-emetụta ọgwụ nje:
Ọzọkwa, a na-eji ọgwụ ahụ eme ọgwụ, na-egbochi nsogbu ndị na-efe efe nke nwere ike ime n'oge arụ ọrụ na ngwe nri, olu, isi, pelvis, akụrụ, nkwonkwo, obi, bile ducts.
Ihe ngbanweDodị usoro onunu ogwu nke Augmentin contraindicated maka iji na ọnụnọ nke ọnọdụ ma ọ bụ ọrịa ndị a:
Fọdụ usoro onunu ogwu nke Augmentin na mgbakwunye na egosipụtara nwere ọgwụ mgbochi ndị ọzọ: 1. Nkwụchi 125 / 31.25: 2. Akwadoro 200 / 28.5 na 400/57:
3. Mbadamba ị allụ ọgwụ (250/125, 500/125 na 875/125):
Ntụziaka maka ojijiUndermụaka na-erubeghị afọ iri na abụọ ma ọ bụ nwee obere ahụ ya na-erughị 40 n'arọ kwesịrị iwere Augmentin naanị na nkwusioru. N'okwu a, ụmụ ọhụrụ na-erughi ọnwa 3 ka enwere ike ịhapụ nkwusioru ya na iji usoro ọgwụ ọgwụ 125 / 31.25 mg. N’aka umuaka kariri onwa ato, o nyeiri ya ohere iji ihe ndozi mee ihe ndi ozo aru oru. N'ihi eziokwu ahụ bụ na ebumnuche Augmentin bụ maka ụmụaka, a na-akpọkarị ya “Augmentin ụmụaka,” na-egosighi ọdịdị usoro (nkwụsị). A na-agbakọ ọnụọgụ nke nkwụsị ahụ n'otu oge dabere na afọ na ogo ahụ nwata ahụ. Ntụziaka maka ojiji na-egosi na achọrọ ego nke nkwusiocha ahụ emechara (ngwọta) na-eji iko ma ọ bụ sirinji tụọ ihe. Iji were ọgwụ a maka ụmụaka, ị nwere ike gwakọta nkwusioru ahụ na mmiri, na nha nke otu na otu, mana naanị mgbe achọpụtara usoro achọrọ.
Iji gbakọọ ego iji ọgwụ ahụ, ịkwesịrị iji ụkpụrụ ndị a: Nkwụsị 200 mg.
Nkwụsị 400 mg.
Nkwusioru 125 mg.
A na-agbakọta usoro onunu ogwu a dabere na ụdị ọrịa, ọkwa, N'ezie, ibu na afọ onye ọrịa. Ekwesịrị icheta na ọ bụ naanị dọkịta nwere ike ịkọtara onye ọrịa ahụ ọgwụ ole achọrọ. Mgbe ị na-agbakọ usoro onunu ogwu, a na-atụ aro ịtụle naanị ọdịnaya sodium nke amoxicillin. Iwu maka nkwadebe nke nkwusioruEkwesịrị ịkwado nkwusioru ahụ ozugbo tupu ị takingụ ọgwụ. Iwu esi nri:
A ga-amarịrị ite ogwu ahụ gharịị tupu ịmalite ojiji ọ bụla. Iji hụ na usoro ọgwụ zuru oke, a na-atụ aro iji okpu ahụ, nke agụnyere na ngwa ahụ. Ekwesịrị ịsachasị okpu ahụ ọ bụla. Ndụ nchekwa nke nkwusiocha ahụ agwụchabeghị ihe karịrị izu 1 na friji. Nkwụsị agaghị agbajikwa. Maka ndị ọrịa na-erubeghị afọ 2, ị nwere ike iji mmiri sie ike 1: 1 gwakọta ọgwụ a kwadebere otu ọgwụ ahụ. NsonaazụA na-ahụta ọgwụ nje dị mma maka ahụ ụmụaka. A nwalere ọgwụ ahụ ruo ọtụtụ afọ, n'ihi nke a, usoro nke usoro ya bụ nke a mụrụ nke ọma. Dị ka o kwesịrị ịdị, mmetụta ndị ọzọ nwere ike ime, mana enwere ike ịnwe ha dị ala.
Enwere ike ịchọta ndepụta zuru ezu nke mmetụta Augmentin na ntuziaka maka ọgwụ. Na kwa ntuziaka maka ojiji nwere ndepụta zuru oke nke ndụmọdụ na usoro nke etu esi eme usoro ọgwụgwọ ọgwụ. Iji chebe ahụ nwatakịrị ahụ na ihe ndị a na-adịghị mma, ọ dị mkpa iji nlezianya lelee usoro ịsụ ọgwụ ọ byụ specialistụ site n'aka ọkachamara ọkachamara. Ọnọdụ nchekwa na ndụ nchekwaỌ na-atụ aro ịchekwa ngwugwu nwere ọgwụ ahụ n'akụkụ akụkụ ụmụaka agaghị eru ya. Ọ dị mkpa iji họrọ ebe kpọrọ nkụ, ọnọdụ okpomọkụ dị na ya ekwesịghị ịdị elu karịa 25 0 C. Ruo ụbọchị 7-10 ị nwere ike ịchekwa nkwusiocha ahụ kwụsịrị na ogo 2-8. Ekwesịrị iji usoro a ga-eji gbanye ya ka ọ bụrụ ihe eji eme ya.
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