Kefsepim - ntụziaka maka ojiji

Ihe ngosi maka iji ogwu Kefsepim na-:
- ka oyi baa (imeru oke na ihe siri ike) nke akpata aru nke Streptococcus pneumoniae (tinyere okwu nke iso bacteremia concomitant), Pseudomonas aeruginosa, Klebsiella pneumoniae ma ọ bụ Enterobacter spp.
- urinary tract na-efe efe (ma ihe siri ike ma na-enweghị nsogbu),
- ọrịa na-efe efe nke anụ ahụ na anụ ahụ dị nro,
- nje dị mgbagwoju anya nke intra-abdominal (yana yana metronidazole) nke Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.,
- usoro na - efe efe mepụtara megide nzụlite nke immunodeficiency steeti (dịka ọmụmaatụ, febrile neutropenia),
- mgbochi nke ibute ọrịa n’oge ịwa ahụ,

Nsonaazụ

Site na usoro nri: afọ ọsịsa, ọgbụgbọ, ọgbụgbọ, afọ ntachi, afọ mgbu, dyspepsia,
Usoro obi: mgbu n’azụ sternum, tachycardia,
Mmeghachi omume nfụkasị ahụ: itching, ọnya anụ ahụ, anafilais, ahụ ọkụ,
Sistemụ akwara Central: isi ọwụwa, nkụda ụra, ehighị ụra nke ọma, paresthesia, nchekasị, ọgba aghara, nsogbu
Usoro iku ume: ụkwara, akpịrị mgbu, ume iku ume,
Mmeghachi omume mpaghara: ya na nchịkwa intravenous - phlebitis, na nchịkwa intramuscular - hyperemia na ihe mgbu na saịtị ịgba ahụ,
Ndị ọzọ: asthenia, sweating, vaginitis, peripheral edema, mgbu azụ, leukopenia, neutropenia, Mmụba na prothrombin,

Ime

Iji ọgwụ ọjọọ eme ihe Kefsepim N’oge ime ime ga-ekwe omume n’okwu ebe ebumnuche eburu n’obi ya na nne karịrị ihe dị n’iru nwa ebu n’afọ.
Ọ bụrụ na ọ dị mkpa, ka iji ọgwụ eme ihe n’oge a na-enye nwa kwesịrị ikpebi nkwụsị nke inye ya ara.

Mmekọrịta na ọgwụ ndị ọzọ

Iji nnukwu ọgwụ aminoglycosides n’otu oge na ọgwụ ahụ KefsepimEkwesịrị ilebara anya iji nyochaa ọrụ akụrụngwa n'ihi ọgwụ nephrotoxicity na ototoxicity nke ọgwụ nje aminoglycoside. A hụrụ Nephrotoxicity mgbe ojiji nke cephalosporins ndị ọzọ n'otu oge yana ọrịa diuretics, dị ka furosemide. Ọgwụ mgbochi anaghị agwọ ọrịa, na-ebelata mkpochapu nke cephalosporins, na-abawanye ohere ịkwafu ọbara. Ntinye uche nke Kefsepim site na 1 ruo 40 mg / ml. dakọtara na ụdị parenteral ndị dị otú a: 0.9% sodium chloride solution maka injection, 5% na 10% ngwọta glucose maka ntụtụ, 6M sodium lactate for injection, glucose 5% na 0.9% sodium chloride solution maka ntụtụ, ngwọta Ringer na lactate na mmiri 5% dextrose maka ntụtụ. Iji gbochie mmekorita ọgwụ nke ọgwụ na ọgwụ ndị ọzọ, azịza nke Kefsepim (dị ka ọtụtụ ọgwụ beta-lactam ndị ọzọ) ekwesịghị ịnwe otu oge na ngwọta nke metronidazole, vancomycin, gentamicin, tobramycin sulfate na netilmicin sulfate. N'ihe banyere nhọpụta nke ọgwụ Kefsepim na ọgwụ ndị a, ị ga-abanye ọgwụ mgbochi ọ bụla iche.

Usoro onunu ogwu:

ntụ ntụ maka ngwọta maka nchịkwa intramuscular

otu karama nwere:

Aha

Ngwakọta, g

0,5 g

1 g

Cefepime hydrochloride monohydrate, gbakọrọ ya na cefepime

(ruru pH sitere na 4.0 ruo 6.0)

ntụ ntụ site na-acha ọcha na-acha ọcha na-acha ọcha.

Omume ọgwụ

Mlọ ọgwụ

Oge Cefepime bụ ọgwụ mgbochi oke nke cephalosporin. Cepepime na-egbochi njikọ nke protein nje nke mgbidi, nwere ụdị dịgasị iche iche nke ihe ndị na-egbochi nje megide gram-positive na gram-negative bacteria, gụnyere ọtụtụ nje na-eguzogide ọgwụ aminoglycosides ma ọ bụ ọgwụ ọgbọ cephalosporin nke atọ dị ka ceftazidime.

Cepepime na-eguzogide mmiri nke hydrolysis nke beta-lactamases dịkarịsịrị ala, ọ nwere obere ala maka beta-lactamases ma banye ngwa ngwa n'ime sel nke nje bacteria na-adịghị mma.

E gosiputara na oge mmebi nwere nkpuru okwu di uku ma obu protein picillin nke nwere ihe dika PSB, udiri anumanu nwere udiri abuo na PSB .. Cepepime nwere otutu ihe banyere nje.

Cepepime na-arụ ọrụ megide microorganisms ndị a:

Staphylococcus aureus (gụnyere ụdị na-emepụta beta-lactamase), staphylococcus epidermidis (gụnyere ụdị na-emepụta beta-lactamase), ụdị ndị ọzọ nke staphylococcus spp. C), akpa ume ụrọ (ptoptoccccus sịnịma) nke gụnyere pensụl na mkpirisi nguzogide na penisilini - opekempe inhibitory ịta sitere na 0.1 ruo 1 μg / ml), beta-hemolytic Streptococcus spp. otu (otu, C, G, F), Streptococcus bovis (otu D), Streptococcus spp. otu na-amaghị nwoke,

Mara: Imirikiti ụdị enterococcal, dị ka Enterococcus faecalis, na staplelococci na-egbochi methicillin na-eguzogide ọgwụ mgbochi cephalosporin ọtụtụ, gụnyere cefepime.

Acinetobacter calcoaceticus (ụdị nke anitratus, lwofii),
Aeromonas hydrophila,
Capnocytophaga spp.,.
Citrobacter spp. (gụnyere Citrobacter diversus, Citrobacter freundii),
Campylobacter jejuni,
Enterobacter spp. (gụnyere Enterobacter cloacae, Enterobacter aerogenes, Enterobacter nkezakii),
Escherichia coli,
Gardnerella vaginalis,
Haemophilus ducreyi,
Haemophilus influenzae (gụnyere beta-lactamase na-emepụta nsogbu),
Haemophilus parainfluenzae, Hafnia alvei,
Klebsiella spp. (gụnyere Klebsiella poniaoniae, Klebsiella oxytoca, Klebsiella ozaenae),
Legionella spp.,
Morganella morganii,
Moraxella catarrhalis (Branhamella catarrhalis) (gụnyere beta-lactamase na-emepụta nsogbu),
Neisseria gonorrhoeae (gụnyere ụdị na-emepụta beta-lactamase),
Neisseria meningitidis,
Pantoea agglomerans (nke a na-akpọbu Enterobacter agglomerans),
Proteus spp. (gụnyere Proteus mirabilis na Proteus vulgaris),
Providencia spp. (gụnyere Providencia rettgeri, Providencia stuartii),
Pseudomonas spp. (gụnyere Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzer),
Salmonella spp.,
Serratia spp. (gụnyere Serratia marcescens, Serratia liquefaciens),
Shigella spp.,
Yersinia enterocolitica,

Rịba ama: oge ikuku anaghị arụ ọrụ megide ọtụtụ ụdị Stenotrophomonas maltophilia, nke a na-akpọbu Xanthomonas maltophilia na Pseudomonas maltophilia).

Anaerobes:

Bacteroides spp.,
Clostridium na-esi ísì ụtọ
Fusobacterium spp.,
Mobiluncus spp.,.
Peptostreptococcus spp.,.
Prevotella melaninogenica (nke a maara Bacteroides melaninogenicus),
Veillonella spp.,

Rịba ama: Cepepime adịghị arụ ọrụ megide Bacteroides fragilis na Clostridium difficile. Nkwụghachi nke abụọ nke microorganisms na cefepime amalite nwayọọ nwayọọ.

Mlọ ọgwụ

Nkezi plasma nke oge ezumike na ndị okenye dị mma n'ọtụtụ oge mgbe otu nchịkwa akwara ji nkeji iri atọ ruo awa iri na abụọ na mkpụkọ kachasị (C_tah) enyere na tebụl dị n'okpuru.

Nkezi plasma cefepime concentrations (μg / ml) mgbe nchịkwa intravenous gasịrị.