Trometamol (trometamol)

Usoro C4H11NO3, aha kemịkal: 2-amino-2- (hydroxymethyl) -1,3-propanediol.
Otu ọgwụ: metabolites / ndị na-achịkwa nguzozi mmiri-electrolyte na steeti acid-base.
Ihe ogwu ogwu: diuretic, weghachi alkaline steeti nke ọbara.

Ngwongwo ogwu

Trometamol nwere akụ nke akụ. Tromethamol mgbe a na-achịkwa ya introvenly na-abawanye ihe nchekwa alkaline nke ọbara ma belata ọdịnaya nke ion hydrogen, si otú a na-ewepụ acididemia. Trometamol na-abanye na membranes cell, na-enyere aka wepu acid acid n’ime, nwere osmotic diuretic na mmetụta hypoglycemic. Trometamol bụ onye na-anabata proton. Trometamol anaghị eme ka ịba ụba carbon dioxide dị n’ọbara, n’adịghị ka sodium bicarbonate. Enwere ike iji Trometamol mee ihe maka iku ume na metabolic acidosis. Trometamol na-akpali diureis, akụrụ na-apụ apụ kpamkpam, mgbe elekere asatọ gachara 75% nke ọgwụ ahụ wepụ ahụ. Ime ka mmamịrị na osmodiuretic mee ihe na-eso akpata mwepụ nke acid na-adịghị ike n'ahụ. Trometamol na-enyocha mmiri na-agba mmiri ma ghara ịsa resubation, n'ihi ya, dị ka osmotic diuretics, na-abawanye diureis ma, site na mkpokọta ụwa, echekwara ngwa ngwa. Mmetụta a na arụ ọrụ akụrụ nwere ike bụrụ ihe a na-achọsi ike na oliguria na metabolic acidosis. Mgbe nchịkwa ọnụ gasịrị, ọ dịghị etinye obi gị dum, na-arụ ọrụ dị ka ọgwụ nnu.

Ọrịa na - esonyere metabolic na acid acidis (oke ọbara ọgbụgba, ujo, mgbasa nke extracorporeal, peritonitis, ọkụ, nnukwu pancreatitis), ọrịa mamịrị nke ketoacidosis, n'oge ịmaliteghachi na oge ịmaliteghachi nke acidosis ngwa ngwa, iwepụ ya na barbiturates, salicylates, salicylates, mmanya, maka mgbochi nke acidosis na nhọpụta nke allopurinol.

Usoro onunu ogwu nke trometamol na onunu ogwu

A na - ahazi ọgwụ Trometamol n'ọtụtụ 120 tụlee kwa nkeji, mmelite ọnụego nchịkwa akwadoghị maka igbochi mmeghachi omume ọjọọ (a na-anabata nchịkwa ngwa ngwa n'ọnọdụ ndị dị iche (dịka ọmụmaatụ, iji wepụ acidosis n'oge njide obi)). A na-edobe dose nke trometamol n'otu n'otu dabere n'ụdị usoro eji eme ihe, ịdị arọ nke onye ọrịa, yana ụkọ ala. Ogo kachasị bụ 1.5 g / kg kwa ụbọchị. Nchịkwa ugboro ugboro nke trometamol ga - ekwe omume ka ụbọchị abụọ ruo ụbọchị atọ gachara.
Nje nke trometamol banye na oghere ihe nwere ike iduga mmepe nke necrosis anụ ahụ.
N'oge ọgwụgwọ, enwere ihe ọghọm nke iku ume iku ume.
N'ime ụmụ amụrụ ọhụrụ, ị ofụ ọgwụ ọjọọ ahụ ga-ekwe omume naanị mgbe uru atụ anya ọgwụgwọ dị gafere ohere ọ nwere ike ibute.
N'oge ọgwụgwọ, ọ dị mkpa iji chịkwaa ịba ụba nke glucose, bicarbonate na ọbara electrolytes ndị ọzọ, steeti acid-base, plasma ionogram, nrụgide nke carbon dioxide, na-eduzi mmanu mmanu.

Nsonaazụ trometamol

Mmeghachi omume mpaghara: phlebitis, spalic venous, mgbakasị mgbidi nke veins, hemolysis, thrombophlebitis, necrosis mpaghara.
Ọrịa metabolism: hypokalemia, hyponatremia, hypochloremia, hypoglycemia.
Ndị ọzọ: hypotension, nsogbu iku ume, nsogbu iku ume, nsogbu iku ume etiti, nsogbu nke dyspeptik (gụnyere ọgbụgbọ, ọgbụgbọ), adịghị ike n'ozuzu.

Mmekọrịta nke trometamol na ihe ndi ozo

Trometamol na-akụda nsonaazụ barbiturates, anticoagulants na-apụtaghị ìhè (ọgwụ coumarin), salicylates.
Trometamol na-eme ka mmetụta nke tricyclic antidepressants tricyclic, narcotic analgesics, chloramphenicol, macrolides (oleandomycin, erythromycin), aminoglycosides.
Site na iji trometamol na ọgwụ antidiabetic jikọtara ọnụ, enwere ike ịkwalite mmetụta hypoglycemic (gụnyere mmepe nke hypoglycemia), ya mere ọ dị mkpa izere iji nkwonkwo mee ihe ma ọ bụ belata ọgwụ ọgwụ antidiabetic.

Dodoụbiga ya ókè

An Withụbiga ọgwụ ókè na-egbu egbu, ihe na-akpata mmụba na-abawanye (adịghị ike n'ozuzu, hypotension, iku ume oge, nkụda mmụọ, ọgbụgbọ, hypoglycemia, vomiting, acid acid base base na mmezi mmiri. Ọgwụgwọ Symptomatic dị mkpa, ọ bụrụ na ọ dị mkpa, ikuku na-arụ ọrụ. Enweghị ọgwụ mgbochi akọwapụtara.

Ọgwụ Farmacology

Site na iji nlekọta iv, ọ na-ebelata mkpokọta nke hydrogen ma na-eme ka nchekwa nke alkaline dị n'ọbara, si otú ahụ wepụ acid ọrịa, na-abanye mkpụrụ ndụ n'ime membranes ma na-enyere aka iwepụ akwara intracellular acidosis, akụrụ anaghị agbanwe agbanwe ma na-akpali diuresis. Mgbe etinyere ya, ọ na-arụ ọrụ dị ka ọgwụ nnu.

Weputara udi ya na ihe mebere ya

Formdị usoro ọgwụ ahụ bụ ihe ngwọta maka infusion. N'ọnọdụ ọ bụ mmiri doro anya, enweghị agba na-enweghị irighiri ala ọzọ. Onweghi isi isi puru iche. Ngwakọta nke usoro onunu ogwu gunyere ihe ndi ozo n’enye ndi ozo. Ngwa inyeaka na-arụ ọrụ dịka ihe na - eme ka ebe a na - edozi ihe, na - echekwa ihe niile dị na - arụ ọrụ nke ihe ahụ na - arụ ọrụ.

1 liter nke usoro onunu ogwu:

• ọ dịghị ihe karịrị 36.5 g nke tromethamol fosfomycin,
• 0.37 g nke potassium chloride,
• ọbụghị karịa 1.75 g nke sodium hydrochloride.

Ihe ndị a dị n’elu bụ isi. Ndị pụrụ iche bụ:

• acetic acid (ihe kariri 99%),
• mmiri dị ọcha.

A na-awụnye ụdị usoro onunu ogwu n'ime akpa (1 l) nke iko transperent. Ejiri mpempe akwụkwọ roba na foil na-acha uhie uhie kpuchie elu karama ahụ.

Acid-base balance na alkalization | Etu esi edozi ahu

Kedu otu esi achọpụta ogo ngwa ngwa nke pH n'ụlọ?

Nnwale dị mfe maka ịchọpụta nguzozi-acid acid na iji iku ume

Omume ọgwụ

Ngwunye ọgwụ gụnyere usoro ọgwụgwọ ọgwụgwọ na-ewepụ ọ̀tụ̀tụ̀ alkaline site na ibelata ion hydrogen. Ihe na-arụ ọrụ, nke bụ akụkụ nke ọgwụ ahụ, bụ ihe na-anabata proton. Mgbe etinyere sodium ion n’ime ahụ, hydrocarbonate na-agbake, nke na-eme ka nrụgide carbon dioxide na -akpata oge ikuku acidosis.

Emebere nguzogide Acid n’ihi ikike nke iji ogwu dozie acidity na pH.

N'okwu a, ngwaahịa nke ọxịdọrọ nke acid nke sitere na organic na-ahapụ ahụ ngwa ngwa.

Mlọ ọgwụ

Site na ịba ụba, ọgwụ ahụ na-abanye kpọmkwem n'ọbara ọbara, nke na-ebugharị ya na anụ ahụ dị nro. A na-enweta nsonaazụ ọgwụgwọ kachasị mgbe awa 1.5-2 gachara mgbe nchịkwa ọgbụgba. Ọgwụ na-ahapụ ahụ gị na mmamịrị na-agbanweghi. Ọ bụrụ na onye ọrịa nwere nsogbu na mmamịrị nke mmamịrị, a na-atụ aro ka ọ wepu ọgwụ ahụ site na mmachi ọgwụ a na-akpata. Iwepu ọkara ndụ na-ewere awa 6-8.

Ihe ngosi maka ojiji

Ihe ngosiputara bu ihe eji eme ihe bu ihe iku ume na metabolic acidosis. Dịka ntuziaka ahụ si dị, ọgwụgwọ ọgwụ ga-ekwe omume site na ọrịa pathologies dịka:

• na-enwu ọkụ nke ogo nke 3-4,
• postosum acidosis,
• acidosis ọbara,
• nsị na salicylates, mmanya methyl na barbiturates,
• cell acidosis, nke tolitere na ndabere nke hypoglycemia,
• ujo ala
• edere n'ụbụrụ,
• edem edere na-egbu egbu,
• Nsogbu gbasara akwara gbasara ịwa ahụ.

Nke a bụ ọgwụ nke nwere ọtụtụ mmetụta dị iche iche, nke a na-eji na orthopedics, neurology, spinal surgery, ọgwụgwọ cancer na ụmụaka na ndị okenye, gụnyere ọrụ ịwa ahụ iji chebe akụkụ ahụ dị na oncology. Na mgbakwunye na iweghachi nguzozi acid-base, ọgwụ ahụ na-eme ka CBS kwụsie ike.

Ihe ngbanwe

Site na contraindications zuru ezu edepụtara na nkọwapụta ahụ, a naghị anabata iji ọgwụ ahụ eme ihe. Ndị a gụnyere:

• afọ ụmụaka (ruo ọnwa iri na abụọ),
• hypersensitivity
• alkaloses,
• ujo (ogbo nke ukwu),
• emesaya
• hypokalemia
• ịhydụbiga mmanya ókè
• hyponatremia.

Ọ bụrụ na onye ọrịa nwere nnukwu gbasara akụrụ, a machibidoro iji ya iwu.

Otu esi ewere trometamol

Sdị usoro usoro onunu ogwu g’eme ka nchịkwa ọgbụgba dị ogologo gafee nkeji iri isii. Ọ bụrụ na maka ahụike, ọ dị mkpa maka nchịkwa ugboro ugboro, mgbe ahụ, a ga-ebelata dose ahụ. A na-ekpebi ọgwụgwọ ọgwụgwọ n'otu n'otu, dabere na ogo ọrịa ahụ.

A na-agbakọ usoro usoro usoro ọgwụgwọ dabere na ịdị arọ nke onye ọrịa. Usoro ọgwụgwọ a na-atụ aro kwa ụbọchị ekwesịghị gafere 36 g / n'arọ nke aro, nke ya na 1000 ml. Thekpụrụ kwa ụbọchị maka ụmụaka gbara afọ 12 agaghị agafe 20-30 ml.

Na-arịa ọrịa shuga

Oke kachasị maka ndị ọrịa na - arịa ọrịa shuga ekwesịghị gafere 10-15 g kwa kilogram 10 nke ịdị arọ. Ogwu dị elu chọrọ mgbakwunye nke sodium chloride. N'ihe nwere ike ịbawanye hypoglycemic coma, a ga-enye insulin na dextrose n'ụdị edozi otu oge na ọgwụ.

Nsonaazụ trometamol

N'ọtụtụ oge, ndị ọrịa na-anabata ọgwụ ahụ nke ọma. Nsonaazụ na-ebilite megide nzụlite usoro ahọpụtara n'ụzọ ọgwụ ezighi ezi:

• mgbagasị mgbidi nke arịa ọbara
• mgbali elu
• venospasm
• thrombophlebitis na saịtị ịgba agba,
• Mbelata nrụgide nkebi
• abawanye na pH
• hypochremia,
• hyponatremia.

Na ọdịda akụrụngwa, a na-amanye mkpụrụ ndụ potassium ngwa ngwa.

Mmetụta ikike ịchịkwa usoro

Ojiji nke ọgwụ n'oge oge ume tupu usoro ịwa ahụ na obere usoro ịwa ahụ nwere ike imetụta ọsọ nke mmeghachi omume psychomotor. A naghị atụ aro ka ịkwọ ụgbọala nke oge ọgwụ.

Ntụziaka pụrụ iche

Ọgwụ ekwesịghị ịdaba na oghere oghere. N'okwu a, ihe ọghọm nke imepe anụ ahụ necrosis na-abawanye. Ọ bụrụ na-ejighi ya, onye ọrịa nwere ike ịda mba iku ume. Nyochaa ọkwa glucose dị mkpa, a ga-ebu ionogram serum kwa oge. N'oge ọgwụgwọ, ịta bicarbonate nwere ike ịba ụba.

Ọ bụrụ na onye ọrịa ahụ nwere ọrịa diuretic, ọ dị mkpa ka a duzie diuresis a manyere ya amanye.

Iwebata ọgwụ ngwa ngwa na-eme ka ohere nke pathologies si na usoro hematopoietic pụta.

Mmekọrịta na ọgwụ ndị ọzọ

Ojiji nke ọgwụ na ọgwụ mgbochi ọgwụ na-ebikọ ohere nke hypoglycemia. A naghị akwado ya ka ịgwakọta ihe dị n'ime otu arịa na ọgwụ ndị ọzọ. Maka ịgwakọta mmanye, ọ dị mkpa ị attentiona ntị na agba nke ihe ngwọta: ọ bụrụ na mmiri mmiri ahụ wee bụrụ urukpuru ma ọ bụ nwee ọhụụ, a machibidoro ya ịbanye onye ọrịa.

Ọgwụ nwere ike ịkwalite ọrụ nke ọtụtụ ọgwụ, gụnyere narcotic analgesics, aminoglycosides, ọgwụ nje (Biseptrim, Monural), chloramphenicol, NSAIDs (Dexketoprofen), tricyclic antidepressants.

Ngwọta infusion na mgbakwunye na anticoagulants na-apụtaghị ìhè (ọgwụ coumarin) salicylates na barbiturates nwere ike belata ọrụ nke ikpeazụ.

Mmanya ndakọrịta

Ihe ndị na-arụ ọrụ n’ụdị usoro onunu ogwu na-enwe ike ịkwalite ọrụ ethanol, si otú a na-akpalite mmepe nke mmụmkpụ anụ ahụ n’ahụ. N’oge eji eme ya, a na-atụ aro ịhapụ ị drinkingụ ihe ọholicụholicụ na-aba n’anya.

Ogwu ahu nwere aha ana - ahazi ya na otutu. Ndị nọchiri ha niile nwere ụdị ọgwụgwọ a na mbụ na ha nwere ike ịdị iche na ihe mejupụtara. Ihe ama ama analogues nke ogwu:

Lokpụrụ analogues na ahụike nwere ọgwụ mgbochi, na ojiji nke iji ya na-aghọ ihe agaghị ekwe omume.

Enwere m ike ịzụta na ndenye ọgwụ

Somefọdụ ụlọ ahịa ọgwụ dị n'ịntanetị, ịnwere ike ịzụta ọgwụ na-enweghị ndenye ọgwụ. N'okwu a, a ga-echetarịrị na ihe ọ bụla akwadoghị mbido ọgwụ a zụtara site na ịntanetị.

Ihe mgbochi maka trometamol umi

Nyochaa ọdịnaya nke glucose na electrolytes ọbara, KShchS bụ ihe dị mkpa.

Trometamol N - ọgwụ emere iji mezie acidosis. A na-eji onye nnọchianya ahụ eme ihe n'ụdị parenteral, ya bụ, a na-ahụ maka ngwa ngwa. M ga-enyocha maka ndị na-agụ akwụkwọ "ntule banyere Health" ntuziaka maka ngwaahịa ọgwụ a.

Yabụ, nkuzi nke trometamol N:

Kedu ihe bụ trometamol N mepụtara na ụdị ntọhapụ ?

Ọgwụ Trometamol N dị na ngwangwa doro anya maka infusion, mmiri mmiri adịghị acha, enweghị isi, ekwesịghị ịnwe ụmụ irighiri mmiri. Ihe ndị dị n’ọrụ ọgwụ ahụ bụ: trometamol, potassium chloride, sodium chloride. N’ime ihe mejupụtara trometamol N, n’etiti inyeaka, enwere ike ịmara ọnụnọ nke glacial acetic acid, yana mmiri maka ịgba ntụtụ.

Emechiri ọgwụ a na karama 500 n'ime iko karama, nke a na-etinye ya na mkpọchi kaadiboodu. Ekwesịrị ịwepụ ngwaahịa ọgwụ na ebe gbara ọchịchịrị. Ndụ shelf bụ afọ abụọ, mgbe nke ahụ gasị ghasasịrị usoro ahụ. A na-ere ọgwụ n'ụlọ ọgwụ.

Gini bu trometamol H ?

Omume nke trometamol N na-enyere aka belata itinye uche nke hydrogen n’ime ahụ. Ihe na-arụ ọrụ bụ ihe a na-akpọ proton anabata. Ezigbo ọgwụ maka metabolic na iku ume acidosis. Ọgwụ ahụ kpụrụ akụrụ jiri ihe dịka pasentị iri asaa na ise.

Kedu ihe na-egosi trometamol H ?

N'ime akaebe nke trometamol N, nkọwa ya na-ezo aka n'iji metabolic na iku ume acidosis, nke pụtara n'ụdị siri ike:

Ọnwụ akpata oyi
Ahịhịa acid Postis,
Ọkụ na-emebi emebi
Na ọrịa ụbụrụ,
Ọnụnọ nke mmịnye ọbara acidosis n'ihi mmịnye ọbara dị ogologo,
Mmepe nke sel acidosis megide ndabere nke nchọpụta hyperglycemic coma,
Mgbe ị na-eji ihe a na-akpọ extracorporeal mgbasa,
Pulmonary edema n'ụdị siri ike ma na-egbu egbu,
Withisonụ mmanya mmanya methyl, na mgbakwunye, barbiturates ma ọ bụ salicylates.

Na mgbakwunye, ọgwụ Trometamol N dị irè na mmepe nke postalution renal ọdịda dara.

Kedu ihe bụ contraindications maka trometamol H? ?

Na contraindications, trometamol N, ntuziaka maka ojiji gụnyere ụdị ndị a:

Ejila ihe ngwọta ahụ ruo otu afọ,
Site na hypersensitivity na mmiri nke ọgwụ ọgwụ.
Na hyponatremia,
Edekwala usọbọ nke alkailis,
Na hypokalemia,
Okpo iku ume na ụdị a na-akpọ ụgwọ akwụ ụgwọ, ọkachasị, enwere mmetụta,
Na ịba ọcha n'anya,
Ọnọdụ ọnụ nke steeti ujo.

N'iji nlezianya mee ihe, a na-eji ọgwụ ahụ maka akwara ezughị ezu ma ọ bụ oke ịba ọcha n'anya.

Kedu ihe bụ ojiji na usoro nke trometamol H ?

Ebumnuche eji trometamol N bụ nke na-aga n’ihu ịba n’ahụ, nke a na-arụ ma ọ dịkarịa ala otu elekere. Ọ bụrụ n’ịchọrọ iji ọgwụ n’echi ya, a na-atụ aro ka a belata ya. Dọkịta dobere ọgwụ ahụ dabere ogo acidosis.

Ọ gwụla ma akọwapụtara ya, ọ na - abụkarị ogo trometamol N dị iche na 5 ruo 10 milliliters nke trometamol N kwa kilogram ahụ / awa, nke ga-adaba na 500 ml / h. N'okwu a, oke kachasị kwa ụbọchị ekwesịghị ịkarị 1.5 g / n'arọ. Ọ bụrụ na ọghọm dị na isonye na hypoglycemia, mgbe ahụ, a ga-elekọta insulin nke nwere usoro dextrose.

Kedu ihe bụ mmetụta trometamol H ?

A, ọgwụ trometamol N na-anabata ndị ọrịa nke ọma. Ọ bụrụ na a na-eme infusion nke ọgwụ ahụ ngwa ngwa, nke a nwere ike ibute ụfọdụ mgbakasị ahụ nke mgbidi venous, a naghị ewepụ hemolysis, na mgbakwunye, ọbara mgbali na-ebelata, mmepe nke venospasm na hypokalemia bụ ihe e ji mara ya, na mmepe nke thrombophlebitis, n'ihi iwe anụ ahụ mpaghara, anaghị ewepụ.

Site na mbelata nke mbufụt nke carbon dioxide ma nwee mmụba n'ọdịdị pH, enwere ike ịchọpụta nkụda mmụọ. Site na mmụba na diuresis, megide mmalite nke iwebata ọgwụ, onye ọrịa ahụ nwere ike inwe hyponatremia, yana hypochloremia. Site na mmepe nke nsonaazụ trometamol N, onye ọrịa kwesịrị ịgwọ ọrịa Symptomatic.

Trometamol N - imeju

A na - ahụta ọrịa nrịba ama nke trometamol N: adịghị ike izugbe, hypotension akwara, edere umeji iku ume, a na - ekpebi hypoglycemia n'ụlọ nyocha, imebi mmiri-electrolyte itule bụ agwa, na mgbakwunye, itule acid-base nwere ike gbanwee. Ọgwụ ọgwụgwọ adịghị adị. Edere onye ọrịa ọrịa usoro ọgwụgwọ Symptomatic. Ọ bụrụ n ’ọnọdụ chọrọ, kesaa ikuku ume.

Ọkpụkpụ nke ọgwụ Tromethamol N banye na nke a na-akpọ oghere nwere ike ibute necrosis anụ ahụ, n'akụkụ nke a, a ga-eji nlezianya were ntụtụ ọgwụ ahụ. Na mgbakwunye, iji gbochie mmepe nke mmetụta ndị dị na ya, ọ dị mkpa iji nwayọọ nwayọọ ewebata ọgwụ ahụ. Njikwa ngwa ngwa ga-ekwe omume naanị na acidosis, mgbe njide ejiri obi wee nwee.

Tupu ị nye ọgwụ Tromethamol H, ị ga-agba mbọ hụ na enweghị ntụpọ na mmezi ahụ, na mgbakwunye, ekwesighi imebi iguzosi ike n'ezi ihe nke vial ahụ. N'ime usoro iji ọgwụ a, ọ dị mkpa iji nyochaa ọkwa nke glucose n'ọbara, yana ikpebi nchịkọta nke bicarbonates, a na-akpọkwa diuresis a na-amanye.

Otu esi edochi trometamol N, gịnị bụ analogues nke ọgwụ ?

Trometamol ọgwụ na-ezo aka analogues nke trometamol N.

Aha ahia: Trometamol N

Usoro onunu ogwu:

Ngwakọta kwa 1 liter nke ihe ngwọta
Bekee arụ ọrụ:
trometamol - 36.30 g,
potassium chloride - 0.37 g,
sodium chloride - 1.75 g.
Ndị ọkachamara: acetic acid 99%, mmiri maka ịgba ntụtụ.
K + - 5 Mm / L, Na + - 30 mM / L, C1 - - 35 mM / L.
Osmolarity osmolarity: 470 mOsmol / l.

Nkọwa: mmiri doro anya, enweghị agba ma ọ bụ nke enweghị agba, enweghị mmiri, enweghị mmiri.

Otu na-ere ọgwụ:

Koodu ATX: B05BB03.

Mlọ ọgwụ
Ebumnuche ọgwụgwọ na trometamol N bụ iji belata mkpụmkpụ nke hydrogen ion site na iwebata ihe na-eme dị ka ndị na-anabata H +.

Tromethamol, nke bụ akụkụ nke Tromethamol H, bụ onye na - anabata proton: tromethamol N 2 С0 3 trometamol-Н + + НС0 3 -

E gosipụtara ojiji nke usoro ọgwụgwọ nke trometamol, nke mbụ, n'ọnọdụ ebe ntinye nke Na + ion jikọtara ya na nlọghachi nke bicarbonate bụ ihe na-adịghị mma maka electrolyte, yana na acidosis nke iku ume, na ntinye nke bicarbonate na-emekwuwanye akụkụ nke nrụgide carbon dioxide.

1 M trometamol na-adọpụ 1 M H 2 C0 3 ma na-enye ahụ ahụ bicarbonate 1 M. N'ihi nke a, a na-ebelata nrụgide nke carbon dioxide na itinye uche nke rogen hydrogen na-enweghị ihe metụtara nkuume. Ya mere, enwere ike iji trometamol mee ihe maka iku ume na metabolic acidosis.

Mlọ ọgwụ Tromethamol na trometamol-N + ka akụrụ na-agbanwegharịghị, mgbe awa asatọ gachara, a na-ekepụ 75% ahụ. Trometamol na-enwu mmiri ma na-agba mmiri mmiri, ọ bụ ya mere na, dị ka osmotic diuretics, na-abawanye diureis ma, site na mkpokọ ikuku ụwa, echekwara ngwa ngwa ya. Mmetụta a na arụ ọrụ gbasara akụrụngwa dịka mgbakwunye nke trometamol nwere ike ịchọ na metabolos acidosis na oliguria.

Ihe ngosi maka ojiji
Sedị siri ike nke metabolic na iku ume acidosis:

• postosum acidosis,
• Site na mmịnye ọbara acidosis n'ihi mmịnye ọbara dị ogologo,
• cell acidosis na mmiri ọgwụ hyperglycemic,
• oke oku
• iji ọgwụ mmekpa ahụ ọzọ n'ịwa ahụ,
• edere n'ụbụrụ,
• ụdị dị iche iche nke edem edem,
• arụ ọrụ ma postolowo ezughi oke,
• nsị na barbiturates, salicylates na mmanya methyl.

• Ọgwụ nzuzo nke ọgwụ ahụ,
• alkaloses,
• nnukwu nsogbu gbasara akwara
• ọrịa okuku umeji na-ala ala (emphysema)
• ujo na ọnụ ala,
• ịhydụbiga mmanya ókè
• hypokalemia
• hyponatremia,
• ụmụaka na-erubeghị afọ 1.

Ikpachapụ anya: sistemụ akụrụngwa na / ma ọ bụ ọdịda imeju.

Ime na lactation
Iji ọgwụ eme ihe n'oge ime na n'ịra nwa ga-ekwe omume naanị ma ọ bụrụ na ebumnuche ebumnuche ya na nne ya karịrị ihe ọ bụla nwere ike ibute nwa ebu n’afọ.

Usoro onunu ogwu na nhazi
A na-ezubere ọgwụ ahụ naanị maka nchịkwa akwara ọbara site na ntanye nke ogologo oge ọ dịkarịa ala otu elekere. Ọ bụrụ na ọ dị mkpa, iwebata n’ụbọchị nke abụọ na nke sochirinụ, a ga-ebelata dose ahụ.

A na-ekpebi ọgwụ ahụ dabere na ogo acidosis dị .. ofzọ nke nhọrọ bụ emebere iche maka ọgwụgwọ n'okpuru nchịkwa steeti acid na-akpata ọbara. N'ihi ya, egoro maka trometamol N chọrọ maka infusion bụ nke kwekọrọ na uru ahụ gbakọrọ agbakwunyere mgbakwunye (BE) na oke ahụ na, belụsọ ma akọwapụtara ya bụ: 1 ml nke trometamol H = BE (mM / L) x n'arọ ahụ x x 2 (ọnụọgụ abụọ) nwetara n'ihi mmụba nke ikike nchekwa mgbe agbakwunye 100 mm acetate / l).

Buffering ìsì
Ọ bụrụ na ọnọdụ teknụzụ maka ikpebi ihe ndị na - egosi ọnọdụ acid-base nke ọbara dị, mgbe ahụ, ọ bụrụ na enwere akara ngosipụta ụlọ ọgwụ, enwere ike ịrụ ọrụ na Tromethamol N. 500 ml / h Thebọchị kwa ụbọchị bụ -1000 (-2000) ml. Dosebọchị kwa ụbọchị maka ụmụaka site na afọ 1 bụ 10-20 ml nke trometamol N / n'arọ ahụ.

Ogo kachasị bụ 1.5 g / kg / ụbọchị. Mgbe ị na-eji ọgwụ ndị dị elu, a na-atụ aro ya (iji zere ibelata mkpokọta electrolytes n'ime ọbara) ịgbakwunye NaCl na ọnụego 1 75 g na KC1 na ọnụego 0.372 g kwa 1 lita nke 3.66% ngwọta. Ọ bụrụ na enwere ihe ize ndụ nke hypoglycemia, a na-atụ aro ka ịhazi otu oge 5-10 / o nke dextrose na insulin (dabere na otu 1 nke insulin kwa 4 g nke dextrose akọrọ).

Mmetụta akụkụ
A na-anabatakarị trometamol N. Ọ bụrụ na ọnụego infused dị oke, enwere ike ịhụ ihe ndị a: mgbakasị mgbidi nke veins na hemolysis, ikekwe mbelata ọbara mgbali, hypokalemia, venospasm. N'ihi mgbakasị anụ ahụ, thrombophlebitis nwere ike ịmalite na saịtị ahụ.

Mbelata ngwa ngwa na nsogbu nke carbon dioxide dioxide na mmụba nke pH nwere ike ibute ịda mbà iku ume. N'akụkụ a, na acidosis nke iku ume, a na-atụ aro ntụtụ nke trometamol H naanị ma ọ bụrụ na ọ ga - ekwe omume ịme ikuku umeji aka na umeji, n'ihi ịba ụba nke insulin na iji ngwa ngwa glucose, hypoglycemia nwere ike ịmalite na mpụta.

N'ihi ụba diuresis, hyponatremia na hypochloremia nwere ike ime. N'ihi hyperkalemia, nke bidoro na mbụ n'ihe banyere nchụpụ nke potassium cellular (ọkachasị, na ọdịda akụrụ), na n'ihi ọnwụ nke abụọ nke potassium, ọ bụrụ na ọ dị mkpa, a chọrọ nlele nke ọkwa potassium na ọbara ọbara (lee ntuziaka pụrụ iche).

Dodoụbiga ya ókè
Ọrịa adịghị ike izugbe, hypotension akwara, nkụda mmụọ, hypoglycemia, mmiri mmiri elektrolyte na itule acid-base.
Ọgwụgwọ: ọ nweghị ọgwụ mgbochi akọwapụtara. Na-eduzi usoro ọgwụgwọ Symptomatic, ọ bụrụ na ọ dị mkpa, ikuku ikuku.

Mmekọrịta na ọgwụ ndị ọzọ
Site na iji trometamol H na ọgwụ antidiabetic n'otu oge, enwere ike nwekwuo mmụba na mmetụta hypoglycemic (ihe ize ndụ nke hypoglycemia), yabụ, n'otu oge a ga-ezere iji ma ọ bụ ibelata dose nke ọgwụ antidiabetic kwekọrọ.

Mgbe ị na-agwakọta n'otu akpa ya na ọgwụ ọgwụ ndị ọzọ, ekwesịrị iburu n'uche na uru pH nke ihe ngwọta nke trometamol H bụ 8.1-8.7, nke nwere ike ibute usoro nke ngwakọta.

Ọ bụrụ na a na-ahụ ntụpọ ma ọ bụ ọrịa opalescence mgbe ị na-agwakọta trometamol N n'otu akpa yana ihe ngwọta ndị ọzọ maka nchịkwa parenteral, a gaghị enwe ike iji ụdị ngwakọta a.

A na - eme ka mmetụta nke narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants na-akawanye mma. A na - eme ka mmetụta nke anticoagulants na - apụtaghị ìhè (ọgwụ coumarin), barbiturates, salicylates na ojiji nke trometamol N. nke na-agagharị.

Ntụziaka pụrụ iche
Ọ bụrụ na ọgwụ abanye n'ọnọdụ ahụ, ọ nwere ike ibute mmepe nke necrosis anụ ahụ. Enwere ihe ọghọm nke ịchọ ịda mba iku ume (lee mmetụta ndị ọzọ).

N'ime usoro iji ọgwụ ahụ, ọ dị mkpa ijikwa ọdịnaya glucose ọbara (ihe ize ndụ nke hypoglycemia), serion ionogram, ịta ahụhụ bicarbonate, nrụgide nke carbon dioxide na nguzogide acid, yana mmanye diuresis. Iji ọgwụ eme ihe n'ime ụmụ amụrụ ọhụrụ ga-ekwe omume naanị ma ọ bụrụ na uru ebumnuche ahụ karịrị ihe ọ bụla enwere ike ibute ya.

Iji zere mmepe nke mmetụta ndị ọzọ, ekwesighi iji trometamol na ọnụego dị elu. A na-anabata nchịkwa ngwa ngwa (ihe ruru 60 ml / min) n'ọnọdụ ndị na-enweghị atụ (dịka ọmụmaatụ, iji wepụ acidosis n'oge njide obi).

Mpempe mwepụta
Ngwọta maka infusion. 500 ml nke ọ bụla n'ụdị m gosipụtara iko karama (Heb. F.), ejiri ụdị m bromobutyl roba stof (Heb. F.) maka ịkpụpu ya na okpu plastik n'okpuru okpu nke alumini nwere onye na-eji plastik etinyere na karama ahụ.
10 vials na kaadiboodu na ntuziaka maka ojiji (maka ụlọ ọgwụ).

Ọnọdụ nchekwa
N’ebe gbara ọchịchịrị na-adịghị elu karịa 25 Celsius. Dowe ọgwụ ahụ ka ụmụaka ghara inweta ya!

Exbọchị mmebi
Afọ 2
Ejila oge emechara ka egosiputara na nkwakọ ngwaahịa ahụ jiri naanị ihe doro anya na vials emebibeghị!

Usoro ahịa ọgwụ ahịa
Site na ndenye ọgwụ.

Companylọ ọrụ na-emepụta ihe
Berlin-Chemie AG Menarini Group Glienicker Veg 125 12489
Berlin Germany

Adreesị ụlọ ọrụ nnọchiteanya na Russia
115162 Moscow, nkp. Shabolovka, ụlọ 31, peeji nke B

A na-egosipụta analogues nke ọgwụ trometamol n, dabere na mkpụrụ okwu ahụike, a na-akpọ "okwu abụọ" - ọgwụ ndị na-agbanwe agbanwe nke nwere otu ma ọ bụ karịa otu ihe ahụ na-arụ ọrụ ka ha na-emetụta ahụ. Mgbe ị na-ahọrọ okwu ntụgharị, tụlee ọ bụghị naanị ọnụ ahịa ha, kamakwa mba mmepụta na aha onye mere ya.

Ndepụta nke analogues

Attentionaa ntị! Ndepụta ahụ nwere okwu ana - egosi trometamol H, nke nwere otu ihe mepụtara, yabụ ị nwere ike ịhọrọ onye dochie onwe gị, na-eburu n'uche ụdị na ọgwụ nke dọkịta gị nyere. Nye ndị na-emepụta ihe si USA, Japan, Western Europe, yana ụlọ ọrụ ndị ama ama sitere na Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime / n'ime, n'ụdị usoro 3.66%, ọkara nke ihe ngwọta maka onye ọrịa nwere oke ahụ dị 60 n'arọ bụ 500 ml / h (ihe dị ka 120 tụlee / min). A na-agbakọ dose ahụ site na usoro: K = B x E, ebe K bụ ego nke trometamol ngwọta (ml), B bụ mbelata ntọala (mmol / l), E bụ ibu ahụ onye ọrịa (n'arọ). Ogo kachasị bụ 1.5 g / kg / ụbọchị. Inwere ike ibanyeghachi tupu oge awa iri asaa na asaa ruo iri asaa na asaa ma ọ bụrụ na ọ dị mkpa, iwebata ụbọchị gara aga belata dose ahụ. Mgbe ị na-eji ọgwụ ndị dị elu, a na-atụ aro ya (iji zere iwetulata mkpokọta electrolytes n'ime ọbara) ịgbakwunye NaCl na ọnụego 1.75 g na KCl na ọnụego 0.372 g kwa 1 lita nke 3.66% ngwọta. Ọ bụrụ na enwere ihe ize ndụ nke hypoglycemia, a na-atụ aro ka ịhazi otu oge 5-10% nke dextrose na insulin (dabere na otu 1 nke insulin kwa 4 g nke dextrose akọrọ).

Ajuju, azịza, nyocha banyere ọgwụ Tromethamol N

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke kachasi nma banyere ogwu ahu di na ntuziaka onye batara ma obu onye ichoro. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Exbọchị mmebi

Usoro usoro

Otu ọgwụ ọgwụ nke trometamol

Nhazi ọkwa nosological (ICD-10)

Njirimara nke ihe trometamol

Ngwurugwu na-acha ọcha. Na mmiri mfe mmiri. Ngwọta nke usoro nwere mmeghachi alkaline.

Ọgwụ Farmacology

Site na iji nlekọta iv, ọ na-ebelata mkpokọta nke hydrogen ma na-eme ka nchekwa nke alkaline dị n'ọbara, si otú ahụ wepụ acid ọrịa, na-abanye mkpụrụ ndụ n'ime membranes ma na-enyere aka iwepụ akwara intracellular acidosis, akụrụ anaghị agbanwe agbanwe ma na-akpali diuresis. Mgbe etinyere ya, ọ na-arụ ọrụ dị ka ọgwụ nnu.

Ojiji nke trometamol

Ọrịa tinyere metabolic acidosis, gụnyere mamịrị ketoacidosis nke na-arịa ọrịa shuga, na-egbu egbu na salicylates, barbiturates, mmanya methyl, nhọpụta nke allopurinol (mgbochi nke acidosis).

Ihe ngbanwe

Hypersensitivity, nnukwu gbasara akụrụ ọdịda.

Ihe mgbochi ngwa

Oge mkpụkọ akwara na / ma ọ bụ imeju imeju, afọ iku ume.

Nsonaazụ nke ihe trometamol

Okpu umeji iku ume, hypotension, nsogbu dyspeptik, hypoglycemia.

Mmekorita

Ọ na-eme ka mmetụta nke narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants, na-ebelata usoro anticoagulants na-apụtaghị ìhè (ọgwụ ndị coumarin), barbiturates, salicylates.

Dodoụbiga ya ókè

A na - amata ya site na ụba nsonaazụ (iku ume oge ụfọdụ, hypotension, ọgbụgbọ, vomiting, hypoglycemia). Ọgwụgwọ bụ Symptomatic.

Ofzọ nlekọta

Ihe mgbochi maka trometamol umi

Nyochaa ọdịnaya nke glucose na electrolytes ọbara, KShchS bụ ihe dị mkpa.

Trometamol N - ọgwụ emere iji mezie acidosis. A na-eji onye nnọchianya ahụ eme ihe n'ụdị parenteral, ya bụ, a na-ahụ maka ngwa ngwa. M ga-enyocha maka ndị na-agụ akwụkwọ "ntule banyere Health" ntuziaka maka ngwaahịa ọgwụ a.

Yabụ, nkuzi nke trometamol N:

Kedu ihe bụ trometamol N mepụtara na ụdị ntọhapụ ?

Ọgwụ Trometamol N dị na ngwangwa doro anya maka infusion, mmiri mmiri adịghị acha, enweghị isi, ekwesịghị ịnwe ụmụ irighiri mmiri. Ihe ndị dị n’ọrụ ọgwụ ahụ bụ: trometamol, potassium chloride, sodium chloride. N’ime ihe mejupụtara trometamol N, n’etiti inyeaka, enwere ike ịmara ọnụnọ nke glacial acetic acid, yana mmiri maka ịgba ntụtụ.

Emechiri ọgwụ a na karama 500 n'ime iko karama, nke a na-etinye ya na mkpọchi kaadiboodu. Ekwesịrị ịwepụ ngwaahịa ọgwụ na ebe gbara ọchịchịrị. Ndụ shelf bụ afọ abụọ, mgbe nke ahụ gasị ghasasịrị usoro ahụ. A na-ere ọgwụ n'ụlọ ọgwụ.

Gini bu trometamol H ?

Omume nke trometamol N na-enyere aka belata itinye uche nke hydrogen n’ime ahụ. Ihe na-arụ ọrụ bụ ihe a na-akpọ proton anabata. Ezigbo ọgwụ maka metabolic na iku ume acidosis. Ọgwụ ahụ kpụrụ akụrụ jiri ihe dịka pasentị iri asaa na ise.

Kedu ihe na-egosi trometamol H ?

N'ime akaebe nke trometamol N, nkọwa ya na-ezo aka n'iji metabolic na iku ume acidosis, nke pụtara n'ụdị siri ike:

Ọnwụ akpata oyi
Ahịhịa acid Postis,
Ọkụ na-emebi emebi
Na ọrịa ụbụrụ,
Ọnụnọ nke mmịnye ọbara acidosis n'ihi mmịnye ọbara dị ogologo,
Mmepe nke sel acidosis megide ndabere nke nchọpụta hyperglycemic coma,
Mgbe ị na-eji ihe a na-akpọ extracorporeal mgbasa,
Pulmonary edema n'ụdị siri ike ma na-egbu egbu,
Withisonụ mmanya mmanya methyl, na mgbakwunye, barbiturates ma ọ bụ salicylates.

Na mgbakwunye, ọgwụ Trometamol N dị irè na mmepe nke postalution renal ọdịda dara.

Kedu ihe bụ contraindications maka trometamol H? ?

Na contraindications, trometamol N, ntuziaka maka ojiji gụnyere ụdị ndị a:

Ejila ihe ngwọta ahụ ruo otu afọ,
Site na hypersensitivity na mmiri nke ọgwụ ọgwụ.
Na hyponatremia,
Edekwala usọbọ nke alkailis,
Na hypokalemia,
Okpo iku ume na ụdị a na-akpọ ụgwọ akwụ ụgwọ, ọkachasị, enwere mmetụta,
Na ịba ọcha n'anya,
Ọnọdụ ọnụ nke steeti ujo.

N'iji nlezianya mee ihe, a na-eji ọgwụ ahụ maka akwara ezughị ezu ma ọ bụ oke ịba ọcha n'anya.

Kedu ihe bụ ojiji na usoro nke trometamol H ?

Ebumnuche eji trometamol N bụ nke na-aga n’ihu ịba n’ahụ, nke a na-arụ ma ọ dịkarịa ala otu elekere. Ọ bụrụ n’ịchọrọ iji ọgwụ n’echi ya, a na-atụ aro ka a belata ya. Dọkịta dobere ọgwụ ahụ dabere ogo acidosis.

Ọ gwụla ma akọwapụtara ya, ọ na - abụkarị ogo trometamol N dị iche na 5 ruo 10 milliliters nke trometamol N kwa kilogram ahụ / awa, nke ga-adaba na 500 ml / h. N'okwu a, oke kachasị kwa ụbọchị ekwesịghị ịkarị 1.5 g / n'arọ. Ọ bụrụ na ọghọm dị na isonye na hypoglycemia, mgbe ahụ, a ga-elekọta insulin nke nwere usoro dextrose.

Kedu ihe bụ mmetụta trometamol H ?

A, ọgwụ trometamol N na-anabata ndị ọrịa nke ọma. Ọ bụrụ na a na-eme infusion nke ọgwụ ahụ ngwa ngwa, nke a nwere ike ibute ụfọdụ mgbakasị ahụ nke mgbidi venous, a naghị ewepụ hemolysis, na mgbakwunye, ọbara mgbali na-ebelata, mmepe nke venospasm na hypokalemia bụ ihe e ji mara ya, na mmepe nke thrombophlebitis, n'ihi iwe anụ ahụ mpaghara, anaghị ewepụ.

Site na mbelata nke mbufụt nke carbon dioxide ma nwee mmụba n'ọdịdị pH, enwere ike ịchọpụta nkụda mmụọ. Site na mmụba na diuresis, megide mmalite nke iwebata ọgwụ, onye ọrịa ahụ nwere ike inwe hyponatremia, yana hypochloremia. Site na mmepe nke nsonaazụ trometamol N, onye ọrịa kwesịrị ịgwọ ọrịa Symptomatic.

Trometamol N - imeju

A na - ahụta ọrịa nrịba ama nke trometamol N: adịghị ike izugbe, hypotension akwara, edere umeji iku ume, a na - ekpebi hypoglycemia n'ụlọ nyocha, imebi mmiri-electrolyte itule bụ agwa, na mgbakwunye, itule acid-base nwere ike gbanwee. Ọgwụ ọgwụgwọ adịghị adị. Edere onye ọrịa ọrịa usoro ọgwụgwọ Symptomatic. Ọ bụrụ n ’ọnọdụ chọrọ, kesaa ikuku ume.

Ọkpụkpụ nke ọgwụ Tromethamol N banye na nke a na-akpọ oghere nwere ike ibute necrosis anụ ahụ, n'akụkụ nke a, a ga-eji nlezianya were ntụtụ ọgwụ ahụ. Na mgbakwunye, iji gbochie mmepe nke mmetụta ndị dị na ya, ọ dị mkpa iji nwayọọ nwayọọ ewebata ọgwụ ahụ. Njikwa ngwa ngwa ga-ekwe omume naanị na acidosis, mgbe njide ejiri obi wee nwee.

Tupu ị nye ọgwụ Tromethamol H, ị ga-agba mbọ hụ na enweghị ntụpọ na mmezi ahụ, na mgbakwunye, ekwesighi imebi iguzosi ike n'ezi ihe nke vial ahụ. N'ime usoro iji ọgwụ a, ọ dị mkpa iji nyochaa ọkwa nke glucose n'ọbara, yana ikpebi nchịkọta nke bicarbonates, a na-akpọkwa diuresis a na-amanye.

Otu esi edochi trometamol N, gịnị bụ analogues nke ọgwụ ?

Trometamol ọgwụ na-ezo aka analogues nke trometamol N.

Aha ahia: Trometamol N

Aha International nonproprietary:

Usoro onunu ogwu:

Ngwakọta kwa 1 liter nke ihe ngwọta
Bekee arụ ọrụ:
trometamol - 36.30 g,
potassium chloride - 0.37 g,
sodium chloride - 1.75 g.
Ndị ọkachamara: acetic acid 99%, mmiri maka ịgba ntụtụ.
K + - 5 Mm / L, Na + - 30 mM / L, C1 - - 35 mM / L.
Osmolarity osmolarity: 470 mOsmol / l.

Nkọwa: mmiri doro anya, enweghị agba ma ọ bụ nke enweghị agba, enweghị mmiri, enweghị mmiri.

Otu na-ere ọgwụ:

Koodu ATX: B05BB03.

Mlọ ọgwụ
Ebumnuche ọgwụgwọ na trometamol N bụ iji belata mkpụmkpụ nke hydrogen ion site na iwebata ihe na-eme dị ka ndị na-anabata H +.

Tromethamol, nke bụ akụkụ nke Tromethamol H, bụ onye na - anabata proton: tromethamol N 2 С0 3 trometamol-Н + + НС0 3 -

E gosipụtara ojiji nke usoro ọgwụgwọ nke trometamol, nke mbụ, n'ọnọdụ ebe ntinye nke Na + ion jikọtara ya na nlọghachi nke bicarbonate bụ ihe na-adịghị mma maka electrolyte, yana na acidosis nke iku ume, na ntinye nke bicarbonate na-emekwuwanye akụkụ nke nrụgide carbon dioxide.

1 M trometamol na-adọpụ 1 M H 2 C0 3 ma na-enye ahụ ahụ bicarbonate 1 M. N'ihi nke a, a na-ebelata nrụgide nke carbon dioxide na itinye uche nke rogen hydrogen na-enweghị ihe metụtara nkuume. Ya mere, enwere ike iji trometamol mee ihe maka iku ume na metabolic acidosis.

Mlọ ọgwụ Tromethamol na trometamol-N + ka akụrụ na-agbanwegharịghị, mgbe awa asatọ gachara, a na-ekepụ 75% ahụ. Trometamol na-enwu mmiri ma na-agba mmiri mmiri, ọ bụ ya mere na, dị ka osmotic diuretics, na-abawanye diureis ma, site na mkpokọ ikuku ụwa, echekwara ngwa ngwa ya. Mmetụta a na arụ ọrụ gbasara akụrụngwa dịka mgbakwunye nke trometamol nwere ike ịchọ na metabolos acidosis na oliguria.

Ihe ngosi maka ojiji
Sedị siri ike nke metabolic na iku ume acidosis:

• postosum acidosis,
• Site na mmịnye ọbara acidosis n'ihi mmịnye ọbara dị ogologo,
• cell acidosis na mmiri ọgwụ hyperglycemic,
• oke oku
• iji ọgwụ mmekpa ahụ ọzọ n'ịwa ahụ,
• edere n'ụbụrụ,
• ụdị dị iche iche nke edem edem,
• arụ ọrụ ma postolowo ezughi oke,
• nsị na barbiturates, salicylates na mmanya methyl.

• Ọgwụ nzuzo nke ọgwụ ahụ,
• alkaloses,
• nnukwu nsogbu gbasara akwara
• ọrịa okuku umeji na-ala ala (emphysema)
• ujo na ọnụ ala,
• ịhydụbiga mmanya ókè
• hypokalemia
• hyponatremia,
• ụmụaka na-erubeghị afọ 1.

Ikpachapụ anya: sistemụ akụrụngwa na / ma ọ bụ ọdịda imeju.

Ime na lactation
Iji ọgwụ eme ihe n'oge ime na n'ịra nwa ga-ekwe omume naanị ma ọ bụrụ na ebumnuche ebumnuche ya na nne ya karịrị ihe ọ bụla nwere ike ibute nwa ebu n’afọ.

Usoro onunu ogwu na nhazi
A na-ezubere ọgwụ ahụ naanị maka nchịkwa akwara ọbara site na ntanye nke ogologo oge ọ dịkarịa ala otu elekere. Ọ bụrụ na ọ dị mkpa, iwebata n’ụbọchị nke abụọ na nke sochirinụ, a ga-ebelata dose ahụ.

A na-ekpebi ọgwụ ahụ dabere na ogo acidosis dị .. ofzọ nke nhọrọ bụ emebere iche maka ọgwụgwọ n'okpuru nchịkwa steeti acid na-akpata ọbara. N'ihi ya, egoro maka trometamol N chọrọ maka infusion bụ nke kwekọrọ na uru ahụ gbakọrọ agbakwunyere mgbakwunye (BE) na oke ahụ na, belụsọ ma akọwapụtara ya bụ: 1 ml nke trometamol H = BE (mM / L) x n'arọ ahụ x x 2 (ọnụọgụ abụọ) nwetara n'ihi mmụba nke ikike nchekwa mgbe agbakwunye 100 mm acetate / l).

Buffering ìsì
Ọ bụrụ na ọnọdụ teknụzụ maka ikpebi ihe ndị na - egosi ọnọdụ acid-base nke ọbara dị, mgbe ahụ, ọ bụrụ na enwere akara ngosipụta ụlọ ọgwụ, enwere ike ịrụ ọrụ na Tromethamol N. 500 ml / h Thebọchị kwa ụbọchị bụ -1000 (-2000) ml. Dosebọchị kwa ụbọchị maka ụmụaka site na afọ 1 bụ 10-20 ml nke trometamol N / n'arọ ahụ.

Ogo kachasị bụ 1.5 g / kg / ụbọchị. Mgbe ị na-eji ọgwụ ndị dị elu, a na-atụ aro ya (iji zere ibelata mkpokọta electrolytes n'ime ọbara) ịgbakwunye NaCl na ọnụego 1 75 g na KC1 na ọnụego 0.372 g kwa 1 lita nke 3.66% ngwọta. Ọ bụrụ na enwere ihe ize ndụ nke hypoglycemia, a na-atụ aro ka ịhazi otu oge 5-10 / o nke dextrose na insulin (dabere na otu 1 nke insulin kwa 4 g nke dextrose akọrọ).

Mmetụta akụkụ
A na-anabatakarị trometamol N. Ọ bụrụ na ọnụego infused dị oke, enwere ike ịhụ ihe ndị a: mgbakasị mgbidi nke veins na hemolysis, ikekwe mbelata ọbara mgbali, hypokalemia, venospasm. N'ihi mgbakasị anụ ahụ, thrombophlebitis nwere ike ịmalite na saịtị ahụ.

Mbelata ngwa ngwa na nsogbu nke carbon dioxide dioxide na mmụba nke pH nwere ike ibute ịda mbà iku ume. N'akụkụ a, na acidosis nke iku ume, a na-atụ aro ntụtụ nke trometamol H naanị ma ọ bụrụ na ọ ga - ekwe omume ịme ikuku umeji aka na umeji, n'ihi ịba ụba nke insulin na iji ngwa ngwa glucose, hypoglycemia nwere ike ịmalite na mpụta.

N'ihi ụba diuresis, hyponatremia na hypochloremia nwere ike ime. N'ihi hyperkalemia, nke bidoro na mbụ n'ihe banyere nchụpụ nke potassium cellular (ọkachasị, na ọdịda akụrụ), na n'ihi ọnwụ nke abụọ nke potassium, ọ bụrụ na ọ dị mkpa, a chọrọ nlele nke ọkwa potassium na ọbara ọbara (lee ntuziaka pụrụ iche).

Dodoụbiga ya ókè
Ọrịa adịghị ike izugbe, hypotension akwara, nkụda mmụọ, hypoglycemia, mmiri mmiri elektrolyte na itule acid-base.
Ọgwụgwọ: ọ nweghị ọgwụ mgbochi akọwapụtara. Na-eduzi usoro ọgwụgwọ Symptomatic, ọ bụrụ na ọ dị mkpa, ikuku ikuku.

Mmekọrịta na ọgwụ ndị ọzọ
Site na iji trometamol H na ọgwụ antidiabetic n'otu oge, enwere ike nwekwuo mmụba na mmetụta hypoglycemic (ihe ize ndụ nke hypoglycemia), yabụ, n'otu oge a ga-ezere iji ma ọ bụ ibelata dose nke ọgwụ antidiabetic kwekọrọ.

Mgbe ị na-agwakọta n'otu akpa ya na ọgwụ ọgwụ ndị ọzọ, ekwesịrị iburu n'uche na uru pH nke ihe ngwọta nke trometamol H bụ 8.1-8.7, nke nwere ike ibute usoro nke ngwakọta.

Ọ bụrụ na a na-ahụ ntụpọ ma ọ bụ ọrịa opalescence mgbe ị na-agwakọta trometamol N n'otu akpa yana ihe ngwọta ndị ọzọ maka nchịkwa parenteral, a gaghị enwe ike iji ụdị ngwakọta a.

A na - eme ka mmetụta nke narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants na-akawanye mma. A na - eme ka mmetụta nke anticoagulants na - apụtaghị ìhè (ọgwụ coumarin), barbiturates, salicylates na ojiji nke trometamol N. nke na-agagharị.

Ntụziaka pụrụ iche
Ọ bụrụ na ọgwụ abanye n'ọnọdụ ahụ, ọ nwere ike ibute mmepe nke necrosis anụ ahụ. Enwere ihe ọghọm nke ịchọ ịda mba iku ume (lee mmetụta ndị ọzọ).

N'ime usoro iji ọgwụ ahụ, ọ dị mkpa ijikwa ọdịnaya glucose ọbara (ihe ize ndụ nke hypoglycemia), serion ionogram, ịta ahụhụ bicarbonate, nrụgide nke carbon dioxide na nguzogide acid, yana mmanye diuresis. Iji ọgwụ eme ihe n'ime ụmụ amụrụ ọhụrụ ga-ekwe omume naanị ma ọ bụrụ na uru ebumnuche ahụ karịrị ihe ọ bụla enwere ike ibute ya.

Iji zere mmepe nke mmetụta ndị ọzọ, ekwesighi iji trometamol na ọnụego dị elu. A na-anabata nchịkwa ngwa ngwa (ihe ruru 60 ml / min) n'ọnọdụ ndị na-enweghị atụ (dịka ọmụmaatụ, iji wepụ acidosis n'oge njide obi).

Mpempe mwepụta
Ngwọta maka infusion. 500 ml nke ọ bụla n'ụdị m gosipụtara iko karama (Heb. F.), ejiri ụdị m bromobutyl roba stof (Heb. F.) maka ịkpụpu ya na okpu plastik n'okpuru okpu nke alumini nwere onye na-eji plastik etinyere na karama ahụ.
10 vials na kaadiboodu na ntuziaka maka ojiji (maka ụlọ ọgwụ).

Ọnọdụ nchekwa
N’ebe gbara ọchịchịrị na-adịghị elu karịa 25 Celsius. Dowe ọgwụ ahụ ka ụmụaka ghara inweta ya!

Exbọchị mmebi
Afọ 2
Ejila oge emechara ka egosiputara na nkwakọ ngwaahịa ahụ jiri naanị ihe doro anya na vials emebibeghị!

Usoro ahịa ọgwụ ahịa
Site na ndenye ọgwụ.

Companylọ ọrụ na-emepụta ihe
Berlin-Chemie AG Menarini Group Glienicker Veg 125 12489
Berlin Germany

Adreesị ụlọ ọrụ nnọchiteanya na Russia
115162 Moscow, nkp. Shabolovka, ụlọ 31, peeji nke B

A na-egosipụta analogues nke ọgwụ trometamol n, dabere na mkpụrụ okwu ahụike, a na-akpọ "okwu abụọ" - ọgwụ ndị na-agbanwe agbanwe nke nwere otu ma ọ bụ karịa otu ihe ahụ na-arụ ọrụ ka ha na-emetụta ahụ. Mgbe ị na-ahọrọ okwu ntụgharị, tụlee ọ bụghị naanị ọnụ ahịa ha, kamakwa mba mmepụta na aha onye mere ya.

Nkọwapụta ọgwụ ọjọọ

Ndepụta nke analogues

Attentionaa ntị! Ndepụta ahụ nwere okwu ana - egosi trometamol H, nke nwere otu ihe mepụtara, yabụ ị nwere ike ịhọrọ onye dochie onwe gị, na-eburu n'uche ụdị na ọgwụ nke dọkịta gị nyere. Nye ndị na-emepụta ihe si USA, Japan, Western Europe, yana ụlọ ọrụ ndị ama ama sitere na Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Nsonaazụ Saịtị

Akụkọ Nlele Ndị ọbịa

Ndị ọbịa Na-akọ Esemokwu Nsonaazụ

Ndị ọbịa na-akọ Ego ọnụahịa

Ndị bịara na-akọ banyere ugboro ole ndị mmadụ na-anabata kwa ụbọchị

Nleta Usoro Ọgwụ Maka Ndị Ọbịa

Ndị ọbịa na-akọ akụkọ banyere ụbọchị ha gwụrụ

Ndị ọbịa na-akọ banyere oge nnabata

Ndị ọbịa atọ kọọrọ afọ ole ha dị

Nleta ndị nleta

Ntụziaka gọọmentị maka ojiji

Trometamol N

Nọmba ndebanye:

Aha International nonproprietary:

Usoro onunu ogwu:

Otu na-ere ọgwụ:

Ngwongwo ogwu

Ihe ngosi maka ojiji

Ihe ngbanwe

Ime na lactation

Usoro onunu ogwu na nhazi

Nsonaazụ

Dodoụbiga ya ókè

Mmekọrịta na ọgwụ ndị ọzọ

Ntụziaka pụrụ iche

Mpempe mwepụta

Ọnọdụ nchekwa

Exbọchị mmebi

Mpempe nnabata, nkwakọ na ngwakọta Trometamol N

Ngwọta maka infusion bụ transperent, enweghị agba ma ọ bụ ihe fọrọ nke nta enweghị, enweghị urughuru, enweghị isi.

Ndị pụrụ iche: acetic acid 99%, mmiri d / i.

500 ml - karama (10) - igbe kaadiboodu.

Ngosi nke ogwu Trometamol N

Sedị siri ike nke metabolic na iku ume acidosis:

• postosum acidosis,
• Site na mmịnye ọbara acidosis n'ihi mmịnye ọbara dị ogologo,
• cell acidosis na mmiri ọgwụ hyperglycemic,
  oke oku
• ujo
• iji ọgwụ mmekpa ahụ ọzọ n'ịwa ahụ,
• edere n'ụbụrụ,
• ụdị dị iche iche nke edem edem,
• arụ ọrụ ma postolowo ezughi oke,
• nsị na barbiturates, salicylates na mmanya methyl.

Usoro usoro onunu ogwu

A na-ezube ọgwụ ahụ naanị maka ọchịchị iv site na ịgbanye infp infusion maka ọ dịkarịa ala 1 awa.

Ọ bụrụ na ọ dị mkpa, iwebata n’ụbọchị nke abụọ na nke sochirinụ, a ga-ebelata dose ahụ.

A na-etinye dose ahụ dabere ogo acidosis dị. Ofzọ ịhọrọ bụ ka emeoro ọgwụ ahụ si agbasa n'okpuru ọchịchị acid na-steeti ọbara. N'ihi ya, ego trometamol N chọrọ maka infusion bụ nke kwekọrọ na mgbakwunye mgbakwunye ezughị ezu (BE) yana ahụ, ma belụsọ akọwapụtara, bụ: 1 ml nke trometamol H = BE (mM / L) x n'arọ ahụ x.

A na - enweta ọnụọgụ abụọ site na mbenata ebe nchekwa ma agbakwunye 100 mm acetate / l).

Ọ bụrụ na ọnọdụ teknụzụ maka ikpebi ihe ndị na - egosi acid-base steeti ọbara, anọghị n ’akara ngosipụta nke ụlọ ọgwụ, na - akpata nkụpu na trometamol N.

Ọ gwụla ma akọwapụtara ya nke ọma, nkezi ogo okenye bụ 5-10 ml nke trometamol N / kg body body / h, nke kwekọrọ na 500 ml / h. Thebọchị kwa ụbọchị bụ 1000 (-2000) ml.

Dosebọchị kwa ụbọchị maka ụmụaka site na afọ 1 bụ 10-20 ml nke trometamol N / n'arọ ahụ.

Ogo kachasị bụ 1.5 g / kg / ụbọchị.

Mgbe ị na-eji ọgwụ ndị dị elu eme ihe, a na-atụ aro ya (iji zere ịbelata mkpokọta electrolytes n'ọbara) ịgbakwunye NaCl na ọnụego 1.75 g na KCl na ọnụego 0.372 g kwa 1 lita nke 3.66% ngwọta.

Ọ bụrụ na enwere ihe ize ndụ nke hypoglycemia, a na-atụ aro ka ịhazi otu oge 5-10% nke dextrose na insulin (dabere na otu 1 nke insulin kwa 4 g nke dextrose akọrọ).

Mmetụta akụkụ

A na-anabatakarị trometamol N. Ọ bụrụ na ọnụego infused dị oke, enwere ike ịhụ ihe ndị a: mgbakasị mgbidi nke veins na hemolysis, ikekwe mbelata ọbara mgbali, hypokalemia, venospasm. N'ihi mgbakasị anụ ahụ, thrombophlebitis nwere ike ịmalite na saịtị ahụ.

Mbelata ngwa ngwa na nsogbu nke carbon dioxide dioxide na mmụba nke pH nwere ike ibute ịda mbà iku ume. N'akụkụ a, na acidosis akụkụ okuku ume, infusion nke trometamol H ka a na-atụ aro naanị ma ọ bụrụ na enwere ike nke ikuku usoro. N'ihi mmụba nke insulin na ịba ụba nke glucose n'ụlọ, hypoglycemia nwere ike ịmalite.

N'ihi ụba diuresis, hyponatremia na hypochloremia nwere ike ime. N'ihi hyperkalemia, nke bidoro na mbụ n'ihe banyere nchụpụ nke potassium cellular (ọkachasị, na ọdịda akụrụ), na n'ihi ọnwụ nke abụọ nke potassium, ọ bụrụ na ọ dị mkpa, a chọrọ nlele nke ọkwa potassium na ọbara ọbara (lee ntuziaka pụrụ iche).

Mkparịta ụka ọgwụ ọjọọ

Site na iji trometamol H na ọgwụ antidiabetic n'otu oge, enwere ike nwekwuo mmụba na mmetụta hypoglycemic (ihe ize ndụ nke hypoglycemia), yabụ, n'otu oge a ga-ezere iji ma ọ bụ ibelata dose nke ọgwụ antidiabetic kwekọrọ.

Mgbe ị na-agwakọta n'otu akpa na ọgwụ ndị ọzọ, ekwesịrị iburu n'uche na uru pH nke ihe ngwọta nke trometamol H bụ 8.1-8.7, nke nwere ike ibute usoro nke ngwakọta.

Ọ bụrụ na a na-ahụ ntụpọ ma ọ bụ ọrịa opalescence mgbe ị na-agwakọta trometamol N n'otu akpa yana ihe ngwọta ndị ọzọ maka nchịkwa parenteral, a gaghị enwe ike iji ụdị ngwakọta a.

A na - eme ka mmetụta nke narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants na-akawanye mma.

Mmetụta nke mgbochi coagulants na-apụtaghị ìhè (usoro coumarin), barbiturates, salicylates na-akụda ike ka ejiri ya na trometamol N.