Mbadamba mbadamba 600: ntuziaka maka ojiji

ihe na - arụ ọrụ - thioctic acid 600 mg

ndị na-ebu ụzọ: ike siri ike, ọkara yinye triglycerides.

shei: Ngwọta 70% sorbitol, na-abụghị ezigbo mkpu (n'ihe nke ihe na-egbu egbu), 85% glycerin (na usoro nke ihe na-egbu egbu), gelatin, titanium dioxide (E 171), carmine varnish (E 120).

Ngwongwo ogwu

N'ime mmadụ, a na-etinye thioctic acid ngwa ngwa mgbe nchịkwa ọnụ gasịrị. N'ihi nsonaazụ nkwuputa nke ụzọ mbụ gafere site na imeju, bioavailability zuru oke (ma e jiri ya tụnyere ọchịchị iv) nke thioctic acid a na-etinye n'ime ụlọ bụ ihe ruru. 20% N'ihi nkesa ngwa ngwa na akwara, ọkara ndụ nke thioctic acid site na plasma n'ime mmadụ bụ ihe dịka nkeji 25.

Site na bioav adị nke thioctic acid mgbe a na-ewere ya ọnụ na usoro usoro onunu ogwu siri ike karịa 60% n'ihe metụtara usoro ọgwụgwọ. Oke plasma kachasị nke ruru. 4 mcg / ml, mezuru mgbe ihe ruru. 0,5 h mgbe nchịkwa ọnụ nke 600 mg nke thioctic acid.

Na nnwale na ụmụ anụmanụ (oke, nkịta), na-eji akara redioaktivu, ọ ga-ekwe omume ịchọpụta tumadi ụzọ ezumike nke excretion (80-90%), ya bụ, n'ụdị metabolites. N'ime mmadụ, ọ bụ naanị ọghọm ihe dị oke egwu a na-ahụ na mmamịrị. Biotransformation na-aputa ihe site na nkpirisi oxidative nke akuku (beta oxidation) na / ma obu site na S-methylation nke isi okwu ndakọrịta.

Thioctic acid na-emeghachi omume na vitro na ogige ion metal (dịka ọmụmaatụ cisplatin). Thioctic acid nwere ụmụ irighiri shuga na-abanye n’ime mmiri na-agbaze agbaze.

Mlọ ọgwụ

Thioctic acid bu ihe di na vitamin-nke ma ihe endogenous nke na eme dika coenzyme na oxidative decarboxylation nke alpha-keto acid. Hyperglycemia kpatara ọrịa mellitus na-eduga n'ikenye glucose na protein matriks nke arịa ọbara yana ịmepụta ngwaahịa njedebe nke ngwaahịa glycosylation na-aga n'ihu ("Advanced Glycosylation End Products"). Usoro a na-eduga n'ịbelata ọbara ọbara endoneural na hypoxia / ischemia endoneural, nke a na-esonye na ịba ụba nke mmepụta radicals n'efu na-emebi irighiri akwara. Na irighiri akwara ozi, achọpụtabeghị ọgwụ antioxidants, dịka glutathione. Ọmụmụ ihe nyocha na-egosi na thioctic acid na-etinye aka na usoro biochemical ndị a, na-ebelata nguzobe nke ngwaahịa glycosylation, na-eme ka ọbara na -akwụsị nke endoneural, na-abawanye ọkwa physiological nke antioxidant glutathione. Ọ na - arụkwa ọrụ dị ka ihe antioxidant megide radikal oxygen na - akpata akwara na - arịa ọrịa shuga. Mmetụta ndị a hụrụ n'oge nnwale ahụ na-atụ aro na site n'enyemaka nke thioctic acid, enwere ike melite ọrụ nke akwara. Nke a metụtara nsogbu uche nke polyneuropathy na-arịa ọrịa shuga, nke nwere ike igosipụta dịka ọnyụnyụ na paresthesia (dịka ọmụmaatụ, ọkụ, mgbu, ọnụọgụ ma ọ bụ mkpọda). Ọmụmụ nyocha a na-egosi nsonaazụ bara uru nke thioctic acid na usoro ọgwụgwọ nke polyneuropathy na-arịa ọrịa mamịrị, yana mgbaàmà ndị ama ama dịka ọkụ, paresthesia, ọnụọgụ na mgbu.

Pharmacodynamics na pharmacokinetics

Inye ahihia gụnyere ihe dị ka ihe na - arụ ọrụ thioctic acid (alfa lipoic acid) n'ụdị nnu etinyere etinne, nke bụ ọgwụ na - egbu mmụọ nke na - ejikọ usoro ntụpọ nke alpha-keto acid decarboxylation.

Ọgwụ Berlition na-ebelata ọkwa plasma. glucose nwekwuo umeji glycogenesighi ike nguzogide insulin, na-akpali cholesterol, na-edozi metabolism nke metabolism. Thioctic acidN'ihi ọrụ antioxidant dị n'ime ya, ọ na-echebe sel nke ahụ mmadụ site na mmebi nke ngwaahịa ha rere ere.

N'ime ndị ọrịa ọrịa shuga thioctic acid na-ebelata ntọhapụ nke ngwaahịa ngwaahịa protein glycation na mkpụrụ ndụ akwara, na - eme ka microcirculation dịkwuo elu ma na - eme ka ọbara na - agbatị endoneural, na - eme ka ịta ahụ nwee ike antioxidant glutathione. N'ihi ikike ịbelata glucose plasma, ọ na-emetụta ụzọ ọzọ nke metabolism ya.

Thioctic acid na-ebelata nnakọta nke ọrịa metabolites ọgwụ ụkwara akwara, si otú a na-enye aka na mbelata ọzịza nke akwara anụ ahụ. Normalizes na ụzọ nke akwara ozi na ike metabolism. Isonye na metabolism abụba, na-abawanye biosynthesis phospholipidsn'ihi nke mebiri emebi nke membranes cell na-gbanwee. Iwepu mmetụta nsi metabolic ngwaahịa mmanya (pyruvic acid, acetaldehyde), na-ebelata mwepụta nke ikuku oxygen na --akasị irighiri akwara ischemia na endoneural hypoxiaMbelata ihe mgbaàmà polyneuropathyn'ụdị paresthesiaọnya na -eme ọkụ, ọnụnọ na ihe mgbu na ụkwụ.

Dabere na ihe ndị e kwuru n'elu, a na-eji ọgwụ thioctic acid arụ ọrụ hypoglycemic ya, ọrụ neurotrophic na antioxidant, yana mmelite ọria metabolism emereme. Jiri na nkwadebe nke ihe eji eme ka aru oru di n’ime ya nnu etinne etinyere na-enye gị ohere ibelata ogo mmetụta mmetụta thioctic acid.

Mgbe a na -ekwu ya site na edere, a na-etinye thioctic acid ngwa ngwa na ngwa ngwa kpamkpam site na nri diges (nri a na-ewere dị ka ibelata ibelata absorption. TCmax na plasma dịgasị n'etiti nkeji 25-60 (ya na nchịkwa iv nke nkeji 10-11). Plasma Cmax bụ 25-38 mcg / ml. Bioavailability nke ihe dịka 30%, Vd nke ihe dị ka 450 ml / kg, AUC nke ihe dịka 5 μg / h / ml.

Thioctic acid nwere ike ibute nsonaazụ mbụ nke “imeju” sitere na imeju. Mwepu nke metabolic na ngwaahịa emere site na usoro mbijighari na akuku ihe eji eme otutu ihe. Ctọ anụ n'ụdị metabolites bụ 80-90% site na akụrụ. T1 / 2 na-ewe ihe dị ka nkeji iri abụọ na ise. Mkpochapụ plasma bụ 10-15 ml / min / n'arọ.

Ihe ngbanwe

A na - egbochi mkpụrụ osisi Berlition na ndị ọrịa na - erubeghị afọ 18, ndị ọrịa nwere mmetụta onwe onye na - arụ ọrụ (thioctic acid) ma ọ bụ ihe ọ bụla nke inyeaka ejiri ya na usoro ọgwụgwọ nke ọgwụ, yana ịgwọ ụmụ nwanyị na ụmụ nwanyị dị ime.

Berlition 300 mbadamba, n'ihi ọnụnọ n'ụdị usoro a lactosecontraindicated na ndị ọrịa na ihe ọ bụla nketa shuga enweghị ndidi.

Maka usoro usoro ọgwụ niile

• imebi / mgbanwe na uto,
• ibelata na plasma ọdịnayaglucose (N'ihi nzipu nke nnabata ya),
• ọgbụgba hypoglycemiagụnyere nkwarụ anya, anya ntughari, hyperhidrosis, isi ọwụwa,
• Ngosipụta nfụkasịgụnyere anụahụ ihe nwu/itchingurticaria ihe ọkụ ọkụ (urticaria), nsogbu anaphylactic (N'okwu ndị dịpụrụ adịpụ).

Agbakwunye maka ụdị parenteral nke ọgwụ

• diplopia,
• na-ere ọkụ na mpaghara ịgba ọgwụ ahụ,
• ogwe,
• thrombocytopathy,
• purpura
• mkpụkpu ume na ụba intracranial mgbali (ekwuputara na usoro nchịkwa ngwa ngwa ma gafere oge adịghị anya).

Berlition, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Ntụziaka gọọmentị maka ojiji nke Berlition 300 bụ otu ihe ahụ maka ntuziaka maka ojiji nke Berlition 600 maka ụdị usoro ọgwụ a (ọgwụ ntụtụ, capsules, mbadamba).

Ngwọta Berlition bu n’obi maka nkwadebe nke infusions bụ n’ebido n’ibe ọgwụ kwa ụbọchị nke 300-600 mg, nke a na-ahụ n’ịkwa ahụ kwa ụbọchị n’ime mmiri na-eji ma ọ dịkarịa ala minit 30, maka izu 2-4. Ngwa ngwa tupu ọgbụgba ahụ, a na-akwado ọgwụ ọgwụ site na ịgwakọta ọdịnaya nke 1 ampoule nke 300 mg (12 ml) ma ọ bụ 600 mg (24 ml) na 250 ml Sodium Chloride Injection (0,9%).

Na njikọ na fotoensitivity nke ngwọta infusion dị njikere, a ga-echedo ya ka ọ ghara ikpughe ọkụ, dịka ọmụmaatụ, ejiri mkpuchi alumini kpuchie ya. N’ụdị a, ihe ga-edozili ya ga-ejide ihe aka ya ihe dịka awa 6.

Mgbe izu 2-4 zuru ezu nke iji ọgwụ eme ihe, ha na-agbanwe gaa na ọgwụgwọ site na iji ụdị ọgwụ ọgwụ. A na-edozi kabetị mmiri ma ọ bụ mbadamba ọgwụ kwa ụbọchị na-elekọta 300-600 mg ma na-ebu ya na afọ efu dịka ihe dị ka ọkara otu awa tupu nri, na-a 100ụ mmiri 100-200 ml.

Ọ bụ dibia bekee na-ekpebi oge niile infusion na ọgwụgwọ ọgwụgwọ, yana ike omume omume ha ugboro ugboro.

Dodoụbiga ya ókè

Ihe mgbaàmà ọjọọ nke ịdoụbiga mmanya ókè thioctic acid ayarade onwe ya ọgbụgbọ na-atụgharị na vomit na isi ọwụwa.

N'ọnọdụ ndị siri ike, enwere ike ịchọpụta ya nsụhọ ma obu mkpali uchemomotorjuputara ogwe, hypoglycemia (tupu coma), nnukwu nsogbu acid-base na lactic acidosisnkọ necrosis ọkpụkpụ otutu okpu okpu, hemolysis, DIC, mgbochi nke ụmị ọkpụkpụ.

Ọ bụrụ na ị na-enyo mmetụta na-egbu egbu nke thioctic acid (dịka ọmụmaatụ, mgbe ị na-ewere ihe karịrị 80 mg nke onye na-ahụ maka ọgwụgwọ kwa kilogram 1 nke ịdị arọ), a na-atụ aro ka a kpọga onye ọrịa n'ụlọ ọgwụ ozugbo wee bido mejuputa usoro anabatakarị iji gbochie nsị na mberede (nhicha eriri afọnnabata anwansi wdg). N'ọdịnihu, usoro ọgwụgwọ Symptomatic ka egosiri.

Ọgwụgwọ lactic acidosis, jisie ike ọdịdọ na ọrịa ndị ọzọ nwere ike itinye ndụ n'ihe gbasara onwe ha kwesịrị ịpụta na ngalaba ahụ nlekọta kpụ ọkụ n'ọnụ. Kpọmkwem ọgwụ mgbochi amaghi. Hemoperfusion, ịba ọcha n'anya na usoro nzacha mmanye ndị ọzọ anaghị arụ ọrụ.

Mwepụta wepụtara ya na ihe mejupụtara

Berdị usoro nke Berlition 600 bụ mkpocha maka nkwadebe nke ihe mgbochi infusion: mmiri doro anya, greenish-edo edo na 24 ml na ampoules iko gbara ọchịchịrị (25 ml) na akara nkwụsịtụ (akara ọcha) na mpempe akwụkwọ ndụ akwụkwọ ndụ na-acha odo odo. 5 pcs. n’ime pọmpụ rọba, n’ime ngwugwu akpa 1 pallet.

Otu ampoule nwere:

• ihe na-arụ ọrụ: thioctic acid - 0.6 g,
• ihe inyeaka: ethylenediamine, mmiri maka ịgba ntụtụ.

Mlọ ọgwụ

Site na nchịkwa nke ọgwụ ọgwụ intraven, a na-enweta mkpokọta kachasị nke thioctic acid na plasma mgbe minit 30 gasịrị. Nha C_max odika 20 μg / ml. Metabolized site ọxịdọrọ nke eriri yinye, yana conjugation. Ise_d (olu ekesa) bụ 450 ml / n'arọ. Ọkpụkpụ nke Thioctic acid na metabolites ya na-abụpụta akụrụ (ụzọ bụ isi mpụga). Ọkagbu ọkara ndụ bụ ihe dịka nkeji iri abụọ na ise.

Berlition 600: ntuziaka maka ojiji (usoro onunu ogwu na usoro)

A na-edozi Berlition 600 n'ime intravenly n'ụdị nke usoro infusion.

Na mbido usoro ọgwụgwọ, a na-enye ọgwụ ọgwụ na ọgwụ nke 600 mg kwa ụbọchị (1 ampoule of concentrate). Dịka iwu, usoro ọgwụgwọ bụ izu izu 2-4, mgbe emesịrị usoro ọgwụgwọ mmezi ya na thioctic acid n'ụdị mbadamba ụrọ na ntinye nke 300-600 mg kwa ụbọchị. Dọkịta ahụ kpebiri ka oge niile ọgwụgwọ, yana ọ dị mkpa maka usoro ọmụmụ ugboro ugboro.

Iji kwadebe osisa nye infusion, ihe dị n’ime otu ampoule na-diliri n’ime mmiri ọgwụ dị n’ime 250 ml. A na-ahazi azịza a rụchara arụmọrụ, nwayọ (opekata mpe nkeji iri atọ). Thioctic acid dị mma na-eyi egwu, yabụ ekwesịghị ịgwakọta ọgwụ ahụ tupu oge eruo. Ekwesiri idozi usoro a kwadebere ka ọkụ ghara ịmị ọkụ.

Nsonaazụ

• metabolism: ọ na - adịkarịghị - mbelata glucose plasma, mgbe ụfọdụ ruo hypoglycemia (nke gosipụtara na mgbaàmà dị ka ọgbụgbọ, isi ọwụwa, ọhụhụ na ọsụsọ dị ukwuu),
• sistemụ akwara na akụkụ ahụ: ọ na - adịkarịghị - mgbanwe na uto, nsogbu ọhụhụ nke binokụl, nkwarụ,
• sisitemu nke hematopoietic: nke ukwuu adịkarịghị - thrombophlebitis, ọgbụgba ọbara ọgbụgba, ọbara ọgbụgba bara ụba n'ihi ọrụ platelet arụ ọrụ,
• mmeghachi omume nfụkasị: dịkarịsịrị - urticaria, itching, ihe ọnya na anụ ahụ, ikpe dịpụrụ adịpụ - ujo anacticlactic,
• mmeghachi omume mpaghara: adịkarịghị - anụ ọkụ na - enwu ọkụ na ntanetị nke ọgwụ infusion,
• Ndị ọzọ: ike iku ume na mmetụta nke ibu dị na isi (pụta na nchịkwa ọgwụ ngwa ngwa ma gafere na nke ha).

Ntụziaka pụrụ iche

Ndị ọrịa nwere ọrịa shuga na-a agentsụ ndị ọrụ hypoglycemic pụrụ iche kwesịrị ịchọrọ ọkwa shuga dị ha mgbe niile (karịchaa na mmalite ọgwụgwọ na Berlition 600). Nke a dị mkpa maka igbochi hypoglycemic steeti. N'ọnọdụ ụfọdụ, enwere ike ịchọ mmegharị insulin ma ọ bụ ọgwụ hypoglycemic nke nchịkwa ọnụ.

Site na nchịkwa akwara ọbara, mmeghachi omume onwe onye nwere ike ime. Ọdịdị nke itching akpụkpọ, ọgbụgbọ, malaise ma ọ bụ ihe ịrịba ama ndị ọzọ nke hypersensitivity bụ ihe na-egosi maka ịkwụsị nke thioctic acid ozugbo.

Mmanya na-egbu egbu na-ebelata Berlition 600, yabụ n'oge ọgwụgwọ ị kwesịrị ịhapụ ị drinksụ mmanya nwere mmanya.

Naanị 0.9% sodium chloride solution ga-eji dị ka ihe mgbaze maka itinye uche. Ekwesịrị ịchekwa azịza a kwadebere na ebe gbara ọchịchịrị, ihe ndị ọzọ na-echebe ya site na ọkụ site na foil aluminom. Ndụ shelf nke ihe ngwọta abụghị 6 awa.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Enweghị data na nsonaazụ Berlition 600 n'ikike onye ọrịa itinye uche ma ọ bụ meghachi omume ozugbo, ebe ọ bụ na emebeghị nnyocha pụrụ iche. N'oge ọgwụgwọ ọgwụ ahụ, akpachara anya kwesịrị igosipụta mgbe ị na-arụ ọrụ ọ bụla metụtara ihe ize ndụ na-arịwanye elu na ndụ na ahụike.

Mkparịta ụka ọgwụ ọjọọ

Berlition 600 na-enwe ike iji ígwè, magnesium, calcium na ọla ndị ọzọ etolite chelate dị iche iche, yabụ aga-ezere iji ha n'otu oge.

Acid Thioctic na-akwalite mmetụta hypoglycemic nke insulin na ọgwụ hypoglycemic, ma na-ebelatakwa ọgwụgwọ ọgwụgwọ nke cisplatin.

Ethanol belata mmebi nke Berlition 600.

Iji kwadebe ihe ngwọta maka infusion, ịnweghị ike iji ihe ngwọta nke fructose, dextrose, glucose, Ringer, yana ihe ngwọta nke na-emekọrịta ihe njikọ diski na SH-otu.

Ihe analogues nke Berlition 600 bụ: Tiolepta, Thioctic acid-Vial, Thiogamma, Thioctacid 600 T, Lipoic acid, Alpha-lipoic acid, Thioctic acid, Lipothioxin, Berlition 300, Thioctacid BV, Espa-Lipon, Octolipen, Lipolion, PolionLolion, Lilonion .

Berlition 600 nyocha

Ọgwụ ahụ enwetawo ọtụtụ nyocha dị mma, ebe ọ bụghị naanị na ọ dị irè, kamakwa ndị ọrịa nabatara ya nke ọma. N'ihi mmetụta antitoxic ya, a na-ejikarị Berlition 600 na ọgwụgwọ nke ịhoụbiga mmanya ókè. Ọ na - enyere aka nke ọma na mgbochi na ọgwụgwọ nke ọrịa shuga, na - adị irè karịa ụfọdụ analogues.

Dabere na nyocha, Berlition 600 enweghị ihe ọ bụla nwere ntụpọ, ma e wezụga nke na-efu nnukwu ego.

Usoro onunu ogwu na nhazi

Dosebọchị kwa ụbọchị bụ 1 capsule nke ọgwụ Berlition® 600 capsules (nke kwekọrọ na 600 mg nke thioctic acid), nke a na-ewere otu oge, ihe dị ka nkeji iri atọ tupu nri mbụ.

Na paresthesia siri ike, ị nwere ike ibu ụzọ jiri thioctic acid mepụta ọgwụ infusion.

Childrenmụaka na ndị nọ n'afọ iri na ụma

Lmụaka na ndị ntorobịa ekwesịghị ịnara capsules 600

Berlition® 600 ka a ga-ebufere afọ efu, na-elo ihe niile ma andụọ ọtụtụ mmiri. Eating eatingụ nri ọnụ n'otu oge nwere ike ime ka mmịcha ahụ sie ike. Ya mere, maka ndị ọrịa na-akọwa ogologo oge nke ịkwa iko, ọ dị ezigbo mkpa na ị beụ ọgwụ ahụ ọkara ọkara tupu nri ụtụtụ.

Ebe ọ bụ ọrịa na-adịghị ala ala banyere polyneuropathy mamịrị, ọgwụgwọ ogologo oge nwere ike ịdị mkpa.

Ihe ndabere maka ọgwụgwọ polyneuropathy na-arịa ọrịa shuga bụ nchịkwa kachasị mma n'ọrịa shuga.

Mwepụta wepụtara na nkwakọ

A na-etinye 15 capsules na mbadamba ihe na-acha uhie uhie nke ihe nkiri PVC (eriri iji PVDH) na fopụl aluminom.

Ihe ngwugwu 1 ma ọ bụ abụọ tinyere ntuziaka maka ojiji ahụike na steeti ahụ na asụsụ Russian ka etinye na ngwugwu kaadiboodu.

Na-echekwa na okpomọkụ agaghị akarị 25 Celsius.

Debe ebe aka ndi umu aka!

Ejila mgbe emechaala!

Mmekorita

N'ihi na thioctic acid njirimara bụ mmekọrịta ya na ndị ọrụ ọgwụgwọ, gụnyere ionic metal complexes (wdg. na platinum Cisplatin) N'akụkụ a, ijikọ Berlition na nhazi ọla nwere ike ibute mbelata arụ ọrụ nke ikpeazụ.

Nlekọta oge ọgwụ ethanol nwere ọgwụ na - eduga na mbelata ọgwụgwọ Berlition.

Acid Thioctic na-eme ka ọrụ hypoglycemic dịkwuo elu ọgwụ ọgwụ hypoglycemic ọgwụ na insulinnke ahụ nwere ike ịchọ mgbanwe nke usoro usoro ha si arụ ọrụ.

Berlition maka ogwu ogwu ekwekorita na ogwu ogwu ejiri ya dika ihe ndabere maka nkwadebe nke ngwakọta mmanu, tinyere azịza ringer na Dextroseyana azịza ndị na-emeghachi na akwa ndọrọ ma ọ bụ ìgwè SH.

Thioctic acid nwere ikike nke ime ka ahịhịa ndị nwere ike ịkpụ ya na ụmụ irighiri shuga.

Usoro ahịa ọgwụ ahịa

Emeputa / Onye nwe Asambodo Ndebanye aha

BERLIN-HEMI AG (MENARINI GROUP)

Gliniker Veg 125

12489 Berlin, Germany

Ihe ngwugwu

Scritndorf nke Glọlọ nke Germany, Obodo Germany

Adreesị nke nzukọ a na-anabata mkpesa sitere n'aka ndị na-azụ ahịa maka ịdị mma nke ngwaahịa (ngwongwo) n'ókèala nke Kazakhstan:

Nnochite nke JSC "Berlin-Chemie AG" na Republic of Kazakhstan

Nọmba ekwentị: +7 727 2446183, 2446184, 2446185

Berlition ma ọ bụ Heptral

Na njikọ na akụrụngwa hepatoprotective nke Berlition, otu ọgwụ ọgwụ nwere mmetụta mweghachi na ya mkpụrụ ndụ imeju, otu n'ime ndị nnọchi anya a ma ama nke Heptral. N’ezie, ọ bụ ihe siri ike ịkọwa ihe banyere ọgwụ abụọ a na-agwọ ọrịa, n’ihi na ha ka nọ n’òtù ọgwụ dị iche iche, gụnyere ihe dị iche iche na-arụ ọrụ ma na-egosipụta usoro dị iche iche, n’agbanyeghi na n’inye ọgwụgwọ ọrịa ọrịa, a na-edochi ha ma ọ bụ na-emeju ibe ha.

N'ihi ezughi oke nyocha nke Berlition na ahụ ụmụaka, ojiji ọ na-ahụ maka ụmụaka bụ nke contraindicated.

Ntụziaka maka ojiji

Mkpụrụ osisi na-ezo aka n'ihe ndị na-eme ka metabolic dị n’usoro nke na-ahazi metabolism nke abụba na carbohydrates. Ihe na-arụ ọrụ nke ọgwụ ahụ bụ thioctic acid. A na-emepụta ọgwụ ahụ na mbadamba ụrọ na n'ụdị itinye uche maka nkwadebe nke ihe ngwọta maka infusion.

Edere akwụkwọ nri maka ndị ọrịa na-arịa ọrịa ndị a:

• polyneuropathy, mepụtara megide mmalite nke ọrịa shuga mellitus na a alcoụrụma na-adịghị ala ala,
• steatohepatitis nke usoro dị iche iche,
• steatosis imeju
• ịba ọcha n'anya
• egbu egbu.

Nsonaazụ

Enwere ike ịhụ mmetụta ndị na-adịghị mma n'oge ọgwụgwọ Berlition:

Urticaria

Niile usoro onunu ogwu:

• nfụkasị, nke nwere ike igosipụta onwe ya na urticaria (mgbe ị na-eji usoro ịgba ntụtụ, mmeghachi omume nfụkasị usoro sistemụ nwere ike ịmalite ruo anafilaisis),
• mbelata nke ọbara shuga, ebe ọ bụ na a na-etinyekwu glucose mma.

Maka mpempe ịgba ọgwụ:

• ogwe
• ọhụụ
• hyperplasia intracranial na mkpụmkpụ ume (a hụrụ ya na ngwa ngwa nke ọgwụ, mmetụta ndị a na - adịghị mma na - agafe onwe ha),
• thrombophlebitis
• ntụpọ ọbara anụ ahụ na akpụkpọ ahụ mucous,
• platelet dị ala,
• ihe mbufụt,
• nụrụ ụtọ njo
• na-ere ọkụ n’ebe a na-agba ya ihe.

Otu mbadamba 1 nwere 300 nke thioctic acid.

Dị ka ngwa ndị ọzọ ọ gụnyere:

• MCC
• ejima
• mmiri ara ehi shuga
• fumed silica,
• E 572,
• sodium croscarmellose.

Na shei nwere ihe ndi a:

• titanium na-acha ọcha
• paraffin mmiri
• hypromellose,
• sodium dodecyl sulfate,
• dye E104 na E110.

Na 1 ampoule nke itinye uche maka nkwadebe nke ihe ngwọta maka infusion, enwere ike ịnwe 300 mg ma ọ bụ 600 mg nke arụ ọrụ.

Dika ihe ndi inyeaka, ihe ndi mmadu nwere mmiri, ethylenediamine, na Berlition 300 nwekwara macrogol.

Pharmacology na pharmacokinetics

Thioctic acid bụ ọgwụ antioxidant. Dị ka coenzyme nke ogige mitochondrial multienzyme, ọ na-ekere òkè na ikuku oxygen nke propanonic acid na alfa-keto acid.

Ọ na-ebelata ọkwa nke glucose n'ọbara ma na-eme ka nchịkọta nke glycogen na imeju, na-enyere aka imeri nguzogide insulin. Na -emezi usoro metabolism nke lipids na carbohydrates, na-eme ka ọrụ imeju dịkwuo mma. Lowers ọkwa nke glucose, lipids na cholesterol n'ime ọbara, nwere mmetụta hepatoprotective.

Mgbe a na -ekwu ya n’onu, ọ na-anabata ya nke ọma site na eriri afọ, ebe nri n’otu oge, nri adsorption na-ebelata. Site na nchịkwa intraven, a na-achọpụta itinye uche kachasị mgbe nkeji iri gachara, mgbe ewere ya ọnụ site na nkeji 40-60.

Na-agagharị na imeju, ihe dị n’ime bụ metabolized, a na-apịpụta ya n’ime akụrụ.

Usoro ịzụta na nchekwa

Nwere ike ịzụta ọgwụ dabere na ndenye dọkịta.

Okwesiri ịchekwa ihe mmachi na oge okpomọkụ na-erughị ogo 25 na ebe gbara ọchịchịrị ebe ụmụaka enweghị ike inweta ya.

Ọgwụ ekwesịghị oyi.

Ndụ nchekwa nke ndị uche bụ ọnwa 36.

Mbadamba kwesịrị ịchekwa n’ebe ụmụ anaghị enweta ya, yana n ’ọnọdụ okpomọkụ agaghị akarị ogo iri abụọ na ise. Ndụ shelf bụ ọnwa 24.

(Hapụ nyocha gị na nkwupụta)

* - Uru dị n'etiti ọtụtụ ndị na-ere ahịa n'oge nleba anya abụghị onyinye a na-enye n'ihu ọha

Ọnụ ahịa mkpụrụ osisi, ebe ị ga-azụ

Na Russia, ọnụahịa nkezi nke Berlition 600 na ampoules Nke 5 bụ 900 rubles, na Berlition 300 na ampoules Nke 5 bụ 600 rubles. Ọnụahịa nke Berlition 600 na capsules Nke 30 bụ ihe dịka 1000 rubles. Ọnụahịa nke Berlition 300 na mbadamba ụrọ 30 bụ ihe dị ka 800 rubles.

Na Ukraine (gụnyere Kiev, Kharkov, Odessa, wdg) Enwere ike ịzụta mkpụrụ osisi Berlition na nkezi: ampoules 300 Nke 5 - 280 hryvnia, ampoules 600 Nke 5 - 540 hryvnia, capsules 300 Nke 30 - 400 hryvnia, capsules 600 Nke 30 - 580 hryvnia , mbadamba 300 Nke 30 - 380 hryvnias.