Liptonorm: ntuziaka maka ojiji, analogues, ọnụahịa, nyocha

Nọmba ndebanye: P Nke 016155/01

Aha ahia ogwu: Liptonorm®

International Nonproprietary Aha: Atorvastatin

Mpempe usoro onunu ogwu: mbadamba mkpuchi

Ngwakọta

Mbadamba ụrọ ọ bụla nwere:
Ihe eji arụ ọrụ - calcium Atorvastatin, na ego nke 10 mg na 20 mg nke atorvastatin
Ndị e mere: carbon dioxide, microcrystalline cellulose, lactose, tween 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium dioxide, polyethylene glycol.

Nkọwa

Mpempe akwụkwọ mkpuchi biconvex na-acha ọcha, gburugburu, biconvex. N'oge ezumike ahụ, mbadamba ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha.

Ndị na-ere ọgwụ: onye nnọchi mmanu mmanu - onye na - egbochi HMG CoA reductase.

ATX CODE S10AA05

Ngwongwo ogwu

Mlọ ọgwụ
Hypolipidem gị n'ụlọnga si ìgwè nke statins. Mainzọ kachasị mkpa nke atorvastatin bụ mgbochi nke ọrụ 3-hydroxy-3-methylglutaryl coenzyme A - (HMG-CoA) reductase, enzyme nke na-ejigide ntụgharị nke HMG-CoA na mevalonic acid. Mgbanwe a bụ otu n'ime ụzọ izizi na cholesterol synthesis chain n'ime ahụ. Mmechi nke atorvastatin cholesterol synthesis na - eduga n'ịbawanye ọrụ nke ndị na - anabata LDL (obere npoproteins dị ala) na imeju, yana na anụ ahụ extrahepatic. Ndị na-anabata ihe a na - ekekọta LDL ma wepụ ha na plasma ọbara, nke na - eduga n'ịbelata cholesterol LDL n'ime ọbara.
Mmetụta antisclerotic nke atorvastatin bụ nsonaazụ nsonaazụ nke ọgwụ na mgbidi nke arịa ọbara na akụkụ ọbara. Ọgwụ ahụ na-egbochi njikọ nke isoprenoids, nke bụ ihe na-eto eto nke mkpụrụ ndụ dị n’ime akwara ọbara. N'okpuru mmetụta nke atorvastatin, mmụba nke endothelium na-eme ka akwara ọbara dị mma. Atorvastatin na-ebelata cholesterol, obere lipoproteins dị ala, apolipoprotein B, triglycerides. Na-akpata mmụba nke HDL cholesterol (nnukwu nha dipoproteins) na apolipoprotein A.
Omume nke ọgwụ ahụ, dịka iwu, na-etolite mgbe izu abụọ nke nchịkwa gachara, a na-enweta nsonaazụ kachasị mgbe izu anọ gachara.

Mlọ ọgwụ
Idopu ihe n’ulo di elu. Oge iji rute ịta ahụhụ kachasị elekere bụ 1-2 elekere, ntinye uche kachasị na ụmụ nwanyị bụ 20% dị elu, AUC (mpaghara dị n'okpuru usoro) bụ 10% dị ala, ntinye uche kachasị na ndị ọrịa nwere nsogbu ịrụ mmanya bụ ugboro iri na isii, AUC ji okpukpu iri na otu karịa nke nkịtị. Nri jiri nwayọ belata ngwa-ngwa na oge iwere ọgwụ (site na 25% na 9%, otu), mana mbelata nke LDL cholesterol yiri nke ahụ na iji atorvastatin na-enweghị nri. Ntinye uche nke atorvastatin mgbe etinyere ya na mgbede dị ala karịa n'ụtụtụ (ihe dịka 30%). Ekpughela mmekọrịta dị n’agbata ogo igba mmata na ị ofụ ọgwụ.
Bioavailability - 14%, bioavailability usoro nke ọrụ mgbochi na-egbochi HMG-CoA reductase - 30%. Usoro bioavailability dị ala bụ n'ihi metabolism metabolism na akpụkpọ anụ mucous nke eriri afọ na n'oge "ụzọ mbụ" site na imeju.
Nkezi ogo nke nkesa bụ 381 l, ihe jikọrọ ya na protein protein plasma bụ 98%.
Ọ metabolized kachasị na imeju n'okpuru ọrụ nke cytochrome P450 CYP3A4, CYP3A5 na CYP3A7 na nguzobe nke metabolites na-arụ ọrụ metabolites (ortho- na para-hydroxylated derivatives, beta-oxidation ngwaahịa).
Mmetụta ọgwụ mgbochi megide ọgwụ mgbochi HMG-CoA dị ihe dịka 70% kpebisiri ike site na ọrụ nke ịmegharị metabolites.
A na - akụ ya na bile mgbe akwara hepatic na / ma ọ bụ extrahepatic metabolism (anaghị ata ahụhụ enterohepatic siri ike).
Ọkara ọkara bụ awa 14. Ọrụ mgbochi ihe mgbochi megide HMG-CoA reductase na-adịgide ruo ihe dịka awa 20-30, n'ihi ọnụnọ nke metabolites na-arụ ọrụ. Ihe na-erughị 2% nke ọgwụ a na-ekpebi n’ime mmamịrị.
Achọghị ya ka ọ dịrị n'oge ịba ọcha n'anya.

Ihe ngosi maka ojiji

Hypercholesterolemia nke mbu, hyperlipidemia agwakọta, heterozygous na hyzycholesterolemia homozygous (dị ka mgbakwunye na nri).

Nlekọta anya na akụkụ ọ bụla nke ọgwụ ahụ, ọrịa imeju na ogbo ahụ (gụnyere ọrịa ịba ọcha n'anya, ịba ọcha n'anya na-arụ ọrụ), mụbara ọrụ nke transminases hepatic (ihe karịrị ugboro atọ ma e jiri ya tụnyere njedebe dị elu nke ụkpụrụ) nke amaghị ama, mmebi imeju (ogo A na B dabere na sistemụ Nwa-Pyug), ọrịa etiology ọ bụla, afọ ime, lactation, afọ rue afọ 18 (etinyere ịdị ike na nchekwa ahụ).

Jiri nlezianya: akụkọ ihe mere eme nke ọrịa imeju, nnukwu elektrọnte electrolyte, endocrine na nsogbu nke metabolic, ahoụrụma, hypotension, nnukwu ọrịa (sepsis), ọdịdọ a na-achịkwaghị achịkwa, nnukwu ịwa ahụ, mmerụ ahụ.

Usoro onunu ogwu na nhazi

Tupu ịmalite ọgwụgwọ na Liptonorm, a ga-ebugharị onye ọrịa ahụ na nri nke na -ebelata mbelata ọbara, nke a ga-ahụrịrị n'oge ọgwụgwọ ya.
N'ime, were oge ọ bụla n'ụbọchị (mana n'otu oge ahụ), n'agbanyeghị nri ị ga-eri.
Usoro akwadoro ịmalite bụ 10 mg otu ugboro n'ụbọchị. Na-esote, a na-ahọrọ dose ahụ n’otu dabere na ọdịnaya cholesterol - LDL. Ekwesịrị ịgbanwe ogwu ahụ ka ọ dịkarịa ala izu anọ. Ogo kachasị kwa ụbọchị bụ 80 mg na 1 dose.

Ihe mbu (heterozygous hereditary na polygenic) hypercholesterolemia (ụdị IIa) na hyperlipidemia agwakọta (ụdị IIb)
Ọgwụgwọ ebido na usoro ọgwụgwọ akwadoro, nke a na-abawanye ka izu anọ nke ọgwụgwọ gasịrị, dabere na nzaghachi onye ọrịa. Oke kachasị kwa ụbọchị bụ 80 mg.

Homozygous hereditary hypercholesterolemia
Usoro ọgwụgwọ bụ otu ihe ahụ na ụdị hyperlipidemia ndị ọzọ. A na-ahọrọ oge izizi iche iche dabere ogo ọrịa ahụ. N'ime ọtụtụ ndị ọrịa nwere hypercholesterolemia homozygous, a na-ahụ mmetụta kachasị mma mgbe ị na-eji ọgwụ ahụ kwa ụbọchị nke 80 mg (otu oge).

N'ime ndị ọrịa nwere ọrịa akụrụ na ndị ọrịa merela agadi, a chọghị ịgbanwe ọgwụ Liptonorm.
N'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ, ekwesịrị ịkpachara anya na nkwụsị nke mkpochapu ọgwụ ahụ n'ahụ. Ekwesịrị iji nlezianya nyochaa ụlọ ọgwụ na ụlọ nyocha, ọ bụrụ na achọpụtara mgbanwe mgbanwe ọrịa, ịbelata ọgwụ ahụ ma ọ bụ kwụsịlata ọgwụgwọ.

Si n'etiti ụjọ usoro: n'ihe karịrị 2% nke ikpe - ehighị ụra nke ọma, dizzness, na-erughị 2% nke ikpe - isi ọwụwa, asthenic syndrome, malaise, iro ụra, ụra abalị, amnesia, paresthesia, neuropathy akụkụ, amnesia, lab ikwu mmetụta, ataxia, facial nerve palsy, hyperkinesis, depression hyperesthesia, ọnwụ nke nsụhọ.
Si uche: amblyopia, ịda ntị na ntị, akpọnwụ nke conjunctiva, nsogbu nke ebe obibi, ọbara ọgbụgba n'anya, ntị chiri, glaucoma, parosmia, ọnwụ nke uto, oke nke uto.
Si usoro obi: n'ihe karịrị 2% nke ikpe - mgbu obi, n'ihe na-erughị 2% - palpitations, vasodilation, migraines, hypotension post ọbara, ọbara mgbali elu, phlebitis, arrhythmia, angina pectoris.
Site na sistemụ hemopoietic: anaemia, lymphadenopathy, thrombocytopenia.
Site na usoro iku ume: N'ihe kariri 2% nke ikpe - ọria, ọrịa rhinitis, na erughi 2% nke ikpe - oyi baa, dyspnea, ụkwara ume ọkụ, imi.
Site na nri digestive: n'ihe karịrị 2% nke ikpe - ọgbụgbọ, obi mgbawa, afọ ntachi ma ọ bụ afọ ọsịsa, flatulence, gastralgia, eriri afọ, anorexia ma ọ bụ agụụ riri, nkụ na-egbu, belching, dysphagia, vomiting, stomatitis, esophagitis, glossitis, nrosive and ulcerative ọnya nke mucous membrane nke oghere ahụ. ọnụ, eriri afọ, ọrịa ịba ọcha n'anya, ịba ọcha n'anya colic, cheilitis, ọnya duodenal, pancreatitis, cholestatic jaundice, ọrụ imeju na-arụ ọrụ, ọbara ọgbụgba, melena, goms ọbara ọgbụgba, tenesmus.
Site na usoro mọzụlụ: n'ihe karịrị 2% nke ikpe - ogbu na nkwonkwo, n'ihe na-erughị 2% nke ikpe - nkwonkwo ụkwụ, bursitis, tendosynovitis, myositis, myopathy, ọrịa ogbu na nkwonkwo, myalgia, rhabdomyolysis, torticollis, ọbara mgbali, nkwonkwo nkwonkwo.
Site na usoro mkpụrụ ndụ: n'ihe karịrị 2% nke ikpe - ọrịa urogenital, ọrịa akụkụ, na-erughị 2% nke ikpe - dysuria (gụnyere pollakiuria, nocturia, urinary incontinence ma ọ bụ njigide urinary, mmamịrị nke urination), nephritis, hematuria, ọbara ọgbụgba, nephrourolithiasis, metrorrhagia, epididymitis, belata libido, enweghi ike, ejaculation.
Na akpukpo ahu: ihe na-erughị 2% nke ikpe - alopecia, xeroderma, ịba ụba ọsụsọ, eczema, seborrhea, ecchymosis, petechiae.
Mmeghachi omume nfụkasị ahụ: n’ihe na-erughị 2% nke ikpe - itching, ọnya anụ ahụ, kọntaktị dermatitis, adịkarịghị - urticaria, angioedema, facial edema, photosensitivity, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (syndrome Lyell's syndrome).
Nnyocha ụlọ nyocha: ihe na-erughị 2% nke ikpe bụ hyperglycemia, hypoglycemia, mmụba nke serine creatine phosphokinase, alkaline phosphatase, albuminuria, mmụba nke alanine aminotransferase (ALT) ma ọ bụ aspartic aminotransferase.
Ndị ọzọ: ihe na-erughị 2% nke ikpe - oke ibu, gynecomastia, mastodynia, exacerbation nke gout.

Dodoụbiga ya ókè

Ọgwụgwọ: ọ nweghị ọgwụ mgbochi akọwapụtara. A na-eme ọgwụgwọ Symptomatic. Ha na - eme ihe iji kwado ọrụ dị mkpa nke anụ ahụ na usoro iji gbochie mmụba ọgwụ ahụ: eriri afọ, oriri nke unyi na - arụ ọrụ. Ọkpụkpụ anụ ahụ adịghị arụ ọrụ.
Ọ bụrụ na enwere ihe ịrịba ama na ọnụnọ nke ihe ndị dị ize ndụ maka mmepe nke nnukwu akwara ọdịda n'ihi rhabdomyolysis (mmerụ ahụ dị oke egwu ma bụrụ nke siri ike), a ga-akwụsị ọgwụ ozugbo.
Ebe ọ bụ na atorvastatin nwere njikọ dị ukwuu na protein plasma, hemodialysis bụ ụzọ na - adịghị mma iji wepu ihe a n'ahụ.

Mmekọrịta na ọgwụ ndị ọzọ

Site na nchịkwa nke oge cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, ọgwụ antifungal (metụtara azoles) na nicotinamide, itinye uche nke atorvastatin na plasma ọbara (yana ihe ize ndụ nke myopathy) na-abawanye. Antacids na-ebelata ịta ahụ site na 35% (nsonaazụ nke cholesterol LDL adịghị agbanwe).
Ojiji atorvastatin na-egbochi ya na ihe mgbochi nchebe nke a maara cytochrome P450 CYP3A4 inhibitors na-abawanye na mmụba nke plasma nke atorvastatin.
Mgbe ị na-eji digoxin na mkpokọta atorvastatin na dose nke 80 mg / ụbọchị, ịta nri digoxin na-abawanye ihe dịka 20%.
Na-eme ka ndọta ahụ dị pasent 20 (mgbe e nyere ya ọgwụ atorvastatin na dose 80 mg / ụbọchị) nke ọgwụ mgbochi nwere noareindrone na ethinyl estradiol.
Mmetụta ịdị ala nke njikọta na colestipol karịrị nke ahụ maka ọgwụ ọ bụla n'otu n'otu.
Site na nchịkwa nke oge a na warfarin, oge prothrombin na-ebelata na ụbọchị mbụ, ka osila dị, mgbe ụbọchị iri na ise gasịrị, ihe ngosi a na-ezigide. N'akụkụ a, ndị ọrịa na-ewere atorvastatin nwere warfarin kwesịrị yikarịrị ka ọ dị na mbụ iji chịkwaa oge prothrombin.
Iji ihe ọpeụpeụ mkpụrụ osisi grape n'oge ọgwụgwọ na atorvastatin nwere ike ibute mmụba nke ọgwụ na plasma ọbara. N'akụkụ a, ndị ọrịa na-a theụ ọgwụ ahụ kwesịrị izere ị drinkingụ ihe ọ juiceụ thisụ a.

Ntụziaka pụrụ iche

Ọrụ imeju na-arụ ọrụ
Ojiji nke HMG-CoA reductase inhibitors iji belata egbugbere ọnụ ọbara nwere ike iduga mgbanwe na usoro biochemical nke na-egosipụta ọrụ imeju.
Ekwesịrị ileba anya na ọrụ imeju tupu ọgwụgwọ, izu isii, izu iri na abụọ ka ebido Liptonorm na mgbe mkpụrụ ọgwụ nke ọ bụla na-abawanye, na kwa oge, dịka ọmụmaatụ, ọnwa 6 ọ bụla. A na-ahụ mgbanwe na ọrụ nke enzymes imeju na ọnwa atọ mbụ mgbe ịmalite ị Liụ Liptonorm. Ekwesịrị inyocha ndị ọrịa nwere mmụba na ọkwa transaminase ruo mgbe ọkwa enzyme ga-alaghachi na nkịtị. N'ọnọdụ na ụkpụrụ nke alanine aminotransferase (ALT) ma ọ bụ aspartic aminotransferase (AST) karịrị okpukpu atọ karịa nke oke anabataghị nke ọma, a na-atụ aro ka ịbelata Liptonorm ma ọ bụ kwụsị ọgwụgwọ.

Akwara akwara
Ndị ọrịa nwere mgbasa myalgia, nkụda mmụọ ma ọ bụ adịghị ike na / ma ọ bụ mmụba dị ukwuu na KFK na-anọchite anya ìgwè dị ize ndụ maka mmepe nke myopathy (akọwapụtara dị ka mgbu mgbu na mmụba na-emetụta ọnụ na KFK karịa ugboro 10 ma e jiri ya tụnyere oke dị elu nke nkịtị).
Mgbe ị na-edepụta ọgwụ njikọta Liptonorm na cyclosporine, ihe dị iche iche nke fibric acid, erythromycin, clarithromycin, immunosuppressants, na ọgwụ antifungal nke usoro azole, yana ọnụọgụ nke niacin nke na-ebute mbelata ọkwa nke lipid, ọ dị mkpa iji nyochaa uru elele na ogo nke ihe ize ndụ na ọgwụgwọ a na nyocha a. onye akara ya ma obu akara ya n’arụ aru, ike ọgwụgwụ ma ọ bụ adịghị ike pụtara, karịchaa n’ọnwa ndị mbụ nke ọgwụgwọ yana mmụba na ntụtụ ọ bụla Reparata.

Ekwesịrị ịkwụsịtụ ọgwụgwọ Liptonorm nwa oge ma ọ bụ kwụsịlata n'ihi mmepe nke ọnọdụ dị oke njọ nke nwere ike ibute ọrịa myopathy, yana ọ bụrụ na enwere ihe ndị dị ize ndụ maka mmepe nke nnukwu akwara ọdịda n'ihi rhabdomyolysis (dịka ọmụmaatụ nnukwu ọrịa, hypotension akwara, nnukwu ịwa ahụ, trauma, nnukwu, ịwa ahụ, nnukwu ahụ, trauma, nnukwu nsogbu metabolic na endocrine, yana enweghi echiche elektrọnte).
N ’N’ime ụmụ nwanyị tozuru oke, na-ejighị ọgwụ mgbochi a pụrụ ịdabere na ya, a gaghị atụ aro iji Liptonorm. Ọ bụrụ na onye ọrịa ahụ na-eme atụmatụ ịtụrụ ime, o kwesịrị ịkwụsị ị Liụ Liptonorm opekata mpe otu ọnwa tupu ịtụrụ ime.
Onye ọrịa ahụ kwesịrị ịkpọtụrụ dọkịta ozugbo ma ọ bụrụ na mgbu na-enweghị nkọwa ma ọ bụ adịghị ike akwara na-eme, karịsịa ma ọ bụrụ na ha na-arịa ọrịa ịba na ahụ ọkụ.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ

Achọpụtaghị mmetụta ọjọọ nke Liptonorm n'ikike ịnya ụgbọ ala ma jiri ya rụọ ọrụ nke chọrọ nlebara anya.

Mpempe mwepụta

Mbadamba ụrọ nke 10 na 20 mg.
Na mbadamba 7, 10 ma ọ bụ 14 na blister Al / PVC.
1, 2, 3, 4 blisters na kaadiboodu tinyere ntuziaka maka ojiji.

Ọnọdụ nchekwa

Ndepụta B. N'ebe kpọrọ nkụ, ọchịchịrị na-erughị 25 Celsius.
Ekwela ka ụmụaka ghara iru ya.

Exbọchị mmebi

Afọ 2 Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Usoro ahịa ọgwụ ahịa

Emeputa:
"M.J. Biopharm", India
113 Jolly Maker Chambers-II, Nariman Point, Mumbai 400021, India
Tele: 91-22-202-0644 Faksị: 91-22-204-8030 / 31

Nnọchi anya na Russian Federation
119334 Russia, Moscow, ul. Kosygina, 15 (GC Orlyonok), ọfịs 830-832

Ihe ngwugwu:
Onye na - ere ọgwụ - Leksredstva OJSC
305022, Russia, Kursk, ul. Ọgbakọ nke abụọ, 1a / 18.
Tel / Faksị: (07122) 6-14-65

Ngwakọta, ụdị ntọhapụ

Ihe na-arụ ọrụ nke Liptonorm bụ atorvastatin. A na - emeju ya site na ihe inye aka: calcium carbonate, cellulose, shuga mmiri ara ehi, hydroxypropyl cellulose, croscarmellose, magnesium stearate, titanium dioxide, polyethylene glycol.

Liptonorm bụ mbadamba ọcha, nke gbara agba, gbajiri agbaji. E nwere ụzọ ọdịiche abụọ nke ọgwụ nwere ihe nwere arụ ọrụ nke 10 ma ọ bụ 20 mg.

Omume ọgwụ

Atorvastatin bụ ihe na-egbochi HMG-CoA reductase inhibitor. Enzyme a dị mkpa maka ahụ mepụta kọlestrọl. Mkpụrụ ndụ Liptonorm bụ otu na ya. Mkpụrụ ndụ akwara na - ewere ya ka ọ bụrụ enzyme, tinye na mmeghachi nke cholesterol guzobe - ọ na - akwụsị. E kwuwerị, Njirimara nke atorvastatin abụghị otu HMG-CoA reductase.

Ọkwa cholesterol na-ada. Iji kwụọ maka ụkọ ya, ahụ ahụ na-amalite imebi ihe ụmụ irighiri ihe nwere LDL, nke na-eduga n'ịbelata ịdị n'otu ha. Ihe ozo cholesterol bu aru ala. Transportbufe sterol, a chọrọ “lipoproteins” dị elu nke ukwuu. N'ihi ya, nọmba ha na-eto.

Mbelata nke cholesterol, LDL, triglycerides na-ebelata ọganihu nke atherosclerosis. Ebe ọ bụ na ngafe ngwaahịa nke metabolism abụba nwere ikike imubanye n’elu arịa ọbara. Mgbe nkwụnye ego ahụ ghọrọ ihe dị mkpa, ọ na-ekpuchi akụkụ ya ụfọdụ ma ọ bụ kpuchie ya kpamkpam. Atherosclerosis nke akwara obi na - eduga n'ọbara obi, ọrịa ụbụrụ, aka na aka - guzobe ọnya trophic, ụkwụ necrosis.

A na-ebelata ịdị irè nke atorvastatin na efu ma ọ bụrụ na mmadụ anaghị eso usoro nri iji wedata cholesterol. Ahụ mmadụ anaghị emefu akụ nke aka ya iji kpuchie ụkọ sterol, maka na o si na nri.

Cholesterol etoju tozuru oke mgbe izu abụọ gachara site na mbido ị theụ ọgwụ. A na - enweta nsonaazụ kachasị mgbe izu anọ gachara.

Atorvastatin metabolites dịpụrụ adịpụ na bile, nke imeju na-emepụta. Na okpu akụkụ, usoro a na-esikwu ike. Ya mere, site na iji ọrịa imeju, a na-ede ọgwụ ahụ nke ọma.

Liptonorm: ngosipụta maka ojiji

Dika ntuziaka maka ojiji nke Liptonorm, edepụtara ọgwụ a ka ọ bụrụ ihe mgbakwunye na usoro ọgwụgwọ nri maka:

• hypercholesterolemia,
• gwakọtara na hyperlipidemia,
• heterozygous na homozygous familial hypercholesterolemia dị ka mgbakwunye na usoro ọgwụgwọ nri,

Ojiji nke atorvastatin na-enyere aka belata ọnya ọnya obi, nkụchi obi na ndị ọrịa nwere ọrịa obi. Na mgbakwunye, ndị ọrịa na-a Liụ Liptonorm adịkarịghị achọ ntachi obi, ntagide, ịga ụlọ ọgwụ nwere nsogbu obi.

Ofzọ nke ngwa, usoro onunu ogwu

Tupu ịmalite ọgwụgwọ na Liptonorm, yana oge niile, onye ọrịa ahụ ga-agbaso ihe oriri.

A na-ewere mbadamba otu ugboro / ụbọchị, na-enweghị aka banyere nri, mana oge niile n'otu oge. Usoro akwadoro ịmalite bụ 10 mg. Ọzọkwa, a na-ahọrọ usoro onyonye ahụ n'otu n'otu, na-eburu n'uche mgbanwe nke mgbanwe cholesterol, LDL. Emeghari usoro onodu ogwu a adighi aghafere oge 1 izu / 4. Ihe kacha anabata ike ị nweta bụ 80 mg. Site na mmeghachi ahụ na-adịghị ike nke ị toụ na atorvastatin, a na-enye onye ọrịa ọgwụ statin dị ike ma ọ bụ ịgbakwunye ọgwụ ndị ọzọ na-ebelata cholesterol (usoro nke bile acid, cholesterol absorption inhibitors).

Na mmebi imeju, ịhọpụta Liptonorm kwesịrị ịnwe nleba anya na arụ ọrụ nke ahụ. Ọ bụrụ na ha gafere oke iwu, a ga-akagbu ọgwụ ahụ ma ọ bụ belata usoro onunu ogwu.

Contraindications, mmetụta dị n'akụkụ

A na-egbochi Liptonorm na ndị nwere mmetụta na atorvastatin, lactose, akụkụ ọ bụla nke ọgwụ ma ọ bụ analog. Mbadamba na-contraindicated na:

• nnukwu ọrịa imeju
• mmụba na ALT, GGT, AST karịa ugboro 3,
• ọrịa siri ike
• cirrhosis
• ụmụaka na-erubeghị afọ 18.

Edere Liptonorm maka ndị nne dị ime, ụmụ nwanyị na-enye nwa ara. Ọ bụrụ n’atụmatụ ịtụrụ ime, a na-akwụsị ọgwụ ahụ opekata mpe ọnwa tupu ụbọchị a. Site na ịtụrụ ime na-akwadoghị, ị ga-akwụsị ị takingụ ọgwụ ahụ, wee gakwuru dọkịta ozugbo. Ọ ga - ekwu maka nsogbu ọghọm dị na nwa ebu n’afọ, ma tụọkwa nhọrọ maka ịme ihe.

Ọtụtụ ndị ọrịa na-anabata ọgwụ ahụ ngwa ngwa. Mmetụta ndị ọghọm ọ bụrụ na ọ dị, dị nwayọọ, na-apụ n'anya mgbe obere oge. Mana ikekwe bekee na-enwe nchekwube nke ihe omume.

Ntụziaka Liptonorm na-adọ aka na ntị maka nsonaazụ ndị a:

• Usoro ụjọ: ụra oge, ure, adịkarịghị isi ọwụwa, ụkwara, ụra, ụra abalị, amnesia, belatara / ịbawanye ụba, ụbụrụ akwara, nsogbu mmetụta uche, mmebi ahụ na-emebi emebi, ahụ mkpọnwụ ihu, enweghị mmụọ.
• Akụkụ anụ ahụ: anya abụọ, ntị na-akụ ntị, anya akọrọ, ntị chiri, glaucoma, ihe ọjọọ.
• Ọkpụkpụ akwara: oge ​​mgbu - mgbu obi, adịghị ala ala, palpitations, hypotension ma ọ bụ ọbara mgbali, arrhythmia, angina pectoris, phlebitis.
• Usoro iku ume: ọtụtụ mgbe - bronchitis, rhinitis, adịkarịghị - oyi baa, ụkwara ume ọkụ, imi.
• Usoro nri: ọgbụgbọ, obi mgbawa, afọ ntachi ma ọ bụ afọ ọsịsa, afọ mgbu, gas, anorexia ma ọ bụ agụụ riri nri, ọnụ na-egbu egbu, na -eme nri, ilo mmiri, ọgbụgbọ, ọnya afọ, ire, eriri afọ, ọnya afọ, ọnya afọ, ọnya afọ, ọnya afọ. , ọrịa ogbu na nkwonkwo, jaundice, ọrụ imeju na-arịa ya, ọbara ọgbụgba, mgbatị ọbara.
• Usoro akwara: mgbe mgbe - ogbu na nkwonkwo, nke na - adịghị ahụkebe - nkwonkwo ụkwụ, bursitis, mgbu nkwonkwo, myositis, myopathy, myalgia, rhabdomyolysis, ịba ụba olu.
• Sistemula mkpụrụ ndụ: ọtụtụ mgbe - ọrịa ọnya ụbụrụ, ọrịa akụkụ, adịkarịghị - dysuria, mbufụt nke akụrụ, ọbara ọgbụgba, mbufụt nke ngwa ule, belata libido, enweghi ike, ejaculation.
• Akpukpo aru: alopecia, iribiga elu, eczema, dandruff, hemorrhage ntụpọ.
• Mmeghachi omume nfụkasị ahụ: itching, ihe ọkụ ọkụ, akparị akparị akpịrị, urticaria, mmeghachi omume hypersensitivity, photoensitivity, anaphylaxis.
• Ndị na-egosi ụlọ nyocha: shuga dị elu / dị ala, ụba CPK, alkaline phosphatase, ALT, AST, GGT, anaemia, thrombocytopenia.
• Ndị ọzọ: uru dị arọ, gynecomastia, iwe nke gout.

Ọtụtụ mgbe, ndị na-ese anwụrụ, ndị aholicụrụma, ndị ọrịa na-arịa ọrịa shuga, enweghị thyroid, ọrịa imeju, hypotension na-ata ahụhụ site na nsonaazụ.

Kwụsị Liptonorm, kpọọkwa dọkịta gị ma ọ bụrụ:

• obi mgbu ma ọ bụ adịghị ike a na-akọwaghị,
• mmụba okpomoku
• ogwe.

Mmekorita

Ọgwụ nwere ike imeghachi ọgwụ ndị a:

• antacids (omeprazole, almagel),
• digoxin
• erythromycin, clarithromycin,
• ndị na-egbochi nchebe
• ụfọdụ ọgwụ mgbochi
• fibrates
• warfarin
• itraconazole, ketoconazole.

Ndị ahịa ọgwụ na Russia adịghị ere ọgwụ ahụ. Ọ kubiela akwụkwọ ndebanye aha. Ọnụahịa Liptonorm n'oge ahịa pụọ ​​na ire ahụ bụ 284 rubles kwa ngwungwu 10 mg, 459 rubles kwa 20 mg.

Enweghi ọgwụ Liptonorm abụghị nsogbu. Enwere otutu analogues nke ogwu nwere otu ihe eji eme ihe. Inwere ike juo n ’ụlọ ahịa ọgwụ:

• Atoris
• Anvistat
• Atomax
• Atọ
• Ihe eji agwu Tulip
• Atorvastitin-OBL,
• Atorvastatin-Teva,
• Atorvastatin MS,
• Atorvastatin Avexima,
• Atorvox
• Vazator
• Lipoford
• Liprimar
• Novostat,
• Torvas
• Torvalip
• Torvacard
• Torvazin.

Na mgbakwunye na ọgwụ ndị a dị n'elu, ị nwere ike bulie analogues Liptonorm site na usoro nke ime ihe:

• simvastatin - 144-346 rubles.,
• lovastatin - 233-475 rubles.,.
• rosuvastatin - 324-913 rub.,
• fluvastatin - 2100-3221 ite.

Statkpụrụ niile nwere otu usoro eji arụ ọrụ, mana nke ọ bụla n'ime ha nwere ihe ha ga-eji rụọ ọrụ. Ya mere, na-agwa dọkịta gị mgbe niile tupu ị gbanwee ọgwụ ahụ.

Ihe ndi edere n’ere ihe omume a doziri
dị ka usoro nchịkọta akụkọ nke saịtị ahụ si dị.

Mwepụta wepụtara ya na ihe mejupụtara

Liptonorm dị n'ụdị mbadamba: ejiri mkpuchi dị ọcha, okirikiri, biconvex kpuchie ya, na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha (pcs iri na anọ. Na blisters, blisters 2 na ngwugwu kaadiboodu).

Ihe na - arụ ọrụ nke ọgwụ ahụ bụ atorvastatin (n'ụdị nnu nke calcium). Na mbadamba 1 ọ nwere 10 ma ọ bụ 20 mg.

Ndị na-ahụ maka ihe: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, tween 80, lactose, hydroxypropyl methyl cellulose, microcrystalline cellulose, titanium dioxide, calcium carbonate, polyethylene glycol.

Ngwakọta na usoro onunu ogwu

Akụkụ kachasị arụ ọrụ nke Liptonorm bụ Atorvastatin calcium trihydrate n'ụdị nnu nke calcium. Otu n’ime ihe inyeaka ya gụnyere:

• carbon dioxide
• Ejima 80,
• MCC
• mgbakwunye nri nri E463 na E572,
• sodium croscarmellose
• lactose
• mmiri dị ọcha.

A na-emepụta Liptonorm n'ụdị mbadamba. Mbadamba ụrọ nke 10 mg ma ọ bụ 20 mg dị na igwe 7, 10, 14, 20, 28 ma ọ bụ 30 PC.

Ihe ngosi maka ojiji

Edere ọgwụ maka ọgwụ cholesterol. Ebumnuche ya bụ igbochi ọdịnaya nwere ike ịmịnye mmadụ ọbara. Kwesịrị iji Liptonorm mee ihe n’usoro dọkịta nyere ya.

Ọgwụ Liptonorm nwere ụdị ọrụ dị iche iche. Ọgwụ nwere mmetụ egbugbere ọnụ yana mmetụta nke na - egbochi atherosclerotic. Mmetụta ịdị ala nke ọgwụ Liptonorm bụ na ihe na-arụ ọrụ ya na-enye aka na mgbochi nke cholesterol na iwepu ụmụ irighiri mmiri LDL na plasma ọbara.

Mmetụta ọgwụ mgbochi atherosclerotic sitere n'eziokwu ahụ bụ na ọgwụ ahụ nwere ike ịkwụsị uto nke mkpụrụ ndụ n’ime arịa ọbara yana belata ọdịnaya nke ihe ndị nwere ike ịmịnye ọbara. N'ihi oke ihe dị iche iche a na-eme, a ga-edenye ọgwụ ahụ maka ọrịa ndị na-esonụ:

• mkpụrụ ndụ ihe nketa ga-eme ka ihe ndị dị na ndụ ghara ịba ụba,
• dyslipidemia,
• hetero - ma ọ bụ ụdị homozygous nke ụdị hypercholesterolemia nke ezinụlọ.

Ekwesighi ịgwakọta Liptonorm na ọgwụ maka oke ibu Liponorm. Na mgbakwunye na eziokwu ahụ bụ na nke ikpeazụ bụ nri mgbakwunye, a na-ere ya naanị capsules.

Nsonaazụ

Ọ bụrụ na onye ọrịa ahụ akpachara anya leghara ọgwụ anya ma ọ bụ gafere mbadamba ihe enyere n'iwu, ọ nwere ike imetụta nsonaazụ ya. Ndobeghi iwu nke usoro ọgwụgwọ nwere ike ibute mmeri usoro na akụrụngwa:

1. CNS Ihe ngosipụta kachasị nke malfunction nke sistemụ ụjọ bụ akpịrị ịkpọ nkụ na nchekasị ụra. N'ebe ndị dịpụrụ adịpụ, ndị ọrịa na-enweta ihe mgbaàmà dịka ụra abalị, asthenia, ataxia, paresis na hyperesthesia, na-eduga na ịda mbà n'obi ruo ogologo oge.
2. Akụkụ anụ ahụ. A na-ahụta ihe mgbaàmà nke imebi ọrụ ha dị ka ọbara ọgbụgba na eyeball, ụkọ mmiri mmiri, enweghị mmetụ ọ bụla mgbe ị na-eri nri, enweghị ike ịchọpụta isi.
3. Usoro mkpụrụ ndụ. Ọrịa Urological na nke nwanyị, nsogbu nke urination, mmepe nke nnukwu nsogbu akụrụngwa n'oge usoro ọgwụgwọ, obere ikike bụ mmeghachi omume kachasị njọ n'oge ọgwụgwọ Liptonorm.
4. Sistem Lymphatic. Usoro ọgwụgwọ nke ahụike nwere ike ịkpalite mmepe nke ọrịa ọbara - lymphadenopathy, anaemia ma ọ bụ thrombocytopenia.
5. Iri nri. Emegaghị iwu usoro onunu ogwu nke mbadamba dika ntuziaka ndi a si eduga na mmepe nke oria eriri afọ na imeju, nke na-egosipụta site na ịchafụ, mkpọtụ, ọgbụgbọ na ọgbụgba, colic imeju, na ọbụna ịba ọcha n'anya.
6. Ọkpụkpụ akụrụngwa. Ndị ọrịa nwere ike ịnwe ọbara mgbali elu akwara, angina pectoris, mkpakọ obi.
7. Sistem di iche-iche. Enwere ike ịmịcha ahụ ma ọ bụ mmeghachi ahụ nfụkasị gụnyere rashes, itching, seborrhea, eczema, urticaria ma ọ bụ ujo na-adịghị ahụkebe.

Ntụziaka maka ojiji

Liptonorm bụ onye nnọchi anya otu ọgwụ ọgwụ ndị a na-eji na ọgwụgwọ nke oke oke itule oke ume. Atorvastatin - akụrụngwa nọ n'ọrụ, nwere mmetụta na-ebelata ike nke ukwuu, ya bụ, ọ na - enyere aka belata ihe dị n’ime ọbara. Ọdịnaya ya n’ime ọbara na-ebili mgbe ihe dị ka elekere 1 gachara. N'ụtụtụ, ọnụ ọgụgụ a dị ihe dịka 30% karịa nke mgbede.

A na-ahụ nsonaazụ a site na iji statins mgbe ụbọchị iri na anọ gachara. Mmetụta kachasị na-enweta naanị mgbe ọnwa 1 ejiri.

Theakingụ ọgwụ ahụ esighi na nri ịbanye n'ime ahụ. Naanị ọnọdụ nke na - eme ka ịdị irè nke iji ọgwụ eme ihe bụ ị ofụ mbadamba ụnyaahụ n'otu oge. Onye ọrịa agaghị agafe iwu - 10 mg kwa ụbọchị. Ceedgabiga usoro ọgwụ kwa ụbọchị nwere ike ibute nnukwu nsogbu ahụike ma kpasuo mmeghachi omume na-adịghị mma.

Tupu ịmalite ọgwụgwọ, ndị dọkịta kwesịrị ilebara ọrụ imeju anya. Ndị ọkachamara na-atụ aro ịkpachara anya ma na-eleta dọkịta mgbe niile iji nyochaa ọrụ imeju maka ọnwa atọ mbụ mgbe ịmalite ọgwụgwọ. Enwere ike ịmeghari dose ọtụtụ izu mgbe ịmalite ọgwụgwọ, mana ọ bụghị oge karịa 1 oge kwa ọnwa. N'oge nnabata ya, ndị dọkịta kwesịrị ọnwa 6 ọ bụla. njikwa mgbanwe na nguzozi enzyme.

Dabere na ọnọdụ eji eme ihe, a ga-echekwa mbadamba ndị ahụ n'ebe dị mma. Ndị na-egosi ogo okpomọkụ n'ime ụlọ a +25 ogo.

Jiri n’oge ime

Amachibidoro ihe eji eme ọgwụ ahụ maka ndị ọrịa n’oge ime na n’oge a na-enye nwa ara (na-enye nwa ara) n’ihi mmetụta ọjọọ ọ ga-ekwe omume n’ahụ́ nwa amụrụ ọhụrụ. Ọ bụrụ na onye ọrịa ahụ na-eme atụmatụ ịtụrụ ime, ọ ka mma ịhapụ ya ọtụtụ ọnwa. Womenmụ nwanyị n'oge ịgwọ Liptonorm ekwesịghị ileghara igbochi afọ ime.

Ihe ndị ọzọ na-egbochi afọ ime gụnyere nwata na oge uto. Ihe omuma banyere imu ihe banyere umuaka nwere ogwu rue oge a.

Ọnụ ahịa ọgwụ ọjọọ

A na-ekpebi ọnụahịa ọgwụ Liptonorm site n'ọtụtụ njirisi - ọnụ ọgụgụ nke blisters na ngwugwu, usoro onunu ogwu, wdg. Na nkezi, enwere ike ịzụta mbadamba 10 mg n'ụlọ ahịa ọgwụ maka 200-250 rubles. Ọnụ ego nke otu ngwugwu 28. 20 mg nke ọ bụla bụ 400-500 rubles.

Na Ukraine, ọnụahịa ọgwụ na usoro onunu ogwu nke 20 mg bụ 250-400 UAH.

Analogs Liptonorm

N'agbanyeghị eziokwu ahụ bụ na Liptonorm bụ ọgwụ dị oke irè, ọ dịghị adabara ndị ọrịa niile. Perskpachara anya na mpaghara nke ọgwụ ahụ na ịpụbiga mmanya ókè bụ isi ihe abụọ mere eji dochie ya na usoro analogue dị ọnụ ala.

Ọgwụ ndị na-esote ya bụ otu analogues nke Liptonorm:

Nyocha Nyocha

Nyocha nyocha ya na-egosi na ndị dọkịta na-edenyekarị onye ọrịa ọgwụ ahụ na-akọwaghị nkọwapụta nke njikwa ya yana nsonaazụ ndị ọ bụla.

Tamara, Moscow: “N’ụbọchị ndị mbụ, mgbe m takingụchara ọgwụ ahụ, amalitere m mgbu afọ, wee na-asụ m n’afọ, mgbe ụbọchị ole na ole gachara, ọgbụgbọ na ọgbụgbọ. Agwaghị m ụzọ gosipụta ihe ngosi ndị a na iwere Liptonorm. Ebe ọ bụ na m na-arịa ọrịa n'ihi eriri afọ site na nwata site na obere mgbanwe na nri m, aghọrọ m onye na-ahụ maka ịmị afọ. N'ihi dọkịta, ahụrụ m ihe kpatara ahụ erughị ala na afọ, mana m ka nwere ajụjụ ahụ. Gịnị kpatara na onye na-ahụ maka nri m na-egosighi ịdọ aka na ntị ka ọ pụta?

Ekaterina, Novosibirsk: “Ibu ibu m buru ibu kemgbe m dị afọ iri na ụma, ma, naanị mgbe m gbara afọ iri atọ, ekpebiri m ilekọta onwe m ma chọpụta ihe kpatara nsogbu m. Nnyocha ụlọ nyocha egosila na ihe kpatara ya bụ cholesterol dị elu na onye na-ahụ maka nri na-edozi ahụ ka ọ depụtara m Liptonorm.N’ụbọchị mbụ, ọbara mgbali elu m ruru 150. N’echi ya n'ụtụtụ mgbali ahụ bụ ihe dị mma, mana mgbe nri ehihie ọ maliri ọzọ ruo 160. Mgbe nke ahụ gasịrị, ekpebiri m ịgụgharị ntuziaka ahụ, na ngwụsị, aghọtara m ihe na-eme. Ọbara mgbali elu m na-arụpụta ọgwụ. Nrụgide ahụ kwụsịrị nanị ụbọchị 5 mgbe ịmalite ọgwụgwọ. ”

Na-achịkọta nyocha niile dị n'elu banyere mbadamba mbadamba Liptonorm, ekwesiri ikwubi na ọ dị mkpa ịkpọtụrụ dọkịta tupu iji ha. Nke mbu, nke a bụ n'ihi eziokwu ahụ bụ na ọgwụ ahụ bụ nke otu statins nke nwere ike igbochi mmụba nke cholesterol. Dị ka ị maara, nhọpụta ma ọ bụ kagbuo ihe ọ bụla nke homonụ nwere ike iburu n’aka onye ọkachamara.

Nke abuo, ogwu ahu nwere otutu contraindications na nsonaazụ ya site na eriri afọ, usoro akwara etiti, akwara obi na sistem ndị ọzọ dị mkpa. Ọkachamara kwesịrị ịkọ ọgwụ, kọwaa njirimara niile nke ngwa ahụ, kọwakwa onye ọrịa banyere nsogbu enwere ike.

Usoro onunu ogwu na nhazi

Tupu o depụta Liptonorm na oge ọ bụla iji ya, onye ọrịa ahụ kwesịrị ịgbaso nri na-eme ka mbelata ọbara.

A na-a oụ ọgwụ ahụ otu oge kwa ụbọchị, n'agbanyeghị nri, n'otu oge.

Ọgwụ nke mbụ kwa ụbọchị na-abụkarị 10 mg. Na-esote, a na-edozi ọgwụ ahụ n'otu n'otu, dabere na ọdịnaya cholesterol nke lipoproteins dị ntakịrị. Oge etiti n’agbata mgbanwe mgbanwe ekwesịghị ịbụ ihe na-erughị izu anọ. Ogo ị na-anabata kwa ụbọchị bụ 80 mg.

Nsonaazụ

Nsonaazụ ndị enwere ike ị ofụ ọgwụ ahụ (ọtụtụ mgbe - karịa 2%, adịkarịghị - erughị 2%):

• Sistemụ akwara Central: ọtụtụ mgbe - ọgbụgbọ, ehighị ụra, adịghị ike - malaise, asthenic syndrome, iro ụra, isi ọwụwa, ụra abalị, mmetụta uche, neuropathy akụkụ, ataxia, paresthesia, ọdịdị ihu, hyperesthesia, hyperkinesia, amnesia, ịda mba, ọnwụ nke nsụhọ.
• Ọkpụkpụ akwara dị iche iche: mgbe mgbe mgbu mgbu, adịkarịghị mgbe postpot hypotension, arrhythmia, vasodilation, ụba obi, angina pectoris, ọbara mgbali elu, phlebitis,
• Ahụ akụkụ: nkụ conjunctiva, glaucoma, hemorrhage anya, amblyopia, ọgba aghara nke ebe obibi, parosmia, na-akụ ntị, ntị, ntị na-emebi emebi, ihe uto,
• Usoro iku ume: ọtụtụ mgbe - rhinitis, bronchitis, adịkarịghị - imi imi, oyi baa, ụkwara ume ọkụ, dyspnea,
• Usoro nri: oge ​​- cheilitis, goms ọbara ọgbụgba, nro na ọnya ọnya nke mucosa, stomatitis, glossitis, akpọnwụ akpọnwụ, afọ ma ọ bụ afọ ọsịsa, obi mgbu, flatulence, ọgbụgbọ, gastralgia, belching, mgbu nke ime, vomiting, dysphagia , esophagitis, anorexia ma ọ bụ agụụ riri, duodenal ọnya afọ, hepatic colic, gastroenteritis, ịba ọcha n'anya, ọrụ imeju na-egbu, cholestatic jaundice, pancreatitis, melena, ọbara ọgbụgba,
• Usoro genitourinary: ọtụtụ mgbe - akụkụ akụkụ, ọrịa urogenital, adịkarịghị - hematuria, nephritis, nephrourolithiasis, dysuria (gụnyere urinary incontinence ma ọ bụ njigide nke urinary, nocturia, pollakiuria, urination mmanu), metrorrhagia, ọbara ọgbụgba, epididymitis, ngba, mbelata nke libido, enweghi ike,
• Usoro akwara: mgbe mgbe - ọrịa ogbu na nkwonkwo, ụkwara - tendosynovitis, bursitis, myositis, myalgia, ọrịa ogbu na nkwonkwo, torticollis, nkwonkwo ụkwụ, nkwonkwo nkwonkwo, ọbara mgbali, myopathy, rhabdomyolysis,
• Usoro nke Hematopoietic: lymphadenopathy, anaemia, thrombocytopenia,
• Ọrịa ịba ọcha na mmeghachi ahụ nfụkasị: adịkarịghị - mmụba na-aba ụba, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, itching, anụ ahụ ọkụ, kọntaktị dermatitis, adịkarịghị - ọdịdị ihu, angioedema, urticaria, photoensitivity, multiforme non-toxic exudative erythema Stevens-Johnson syndrome, anaphylaxis,
• Ihe ngosi nke ulo-akwukwo: adighi ike - albuminuria, hypoglycemia, hyperglycemia, oru ndi alkaline phosphatase, serum creatinine phosphokinase na hepatic transaminases,
• Ndị ọzọ: adịkarịghị - mastodynia, gynecomastia, uru dị arọ, njọ nke gout.

Ntụziaka pụrụ iche

N’oge ahụ dum, ọ dị mkpa ileba anya nke ọma n’ihe banyere ụlọ ọgwụ na ihe nyocha nke ọrụ arụ. Ọ bụrụ na achọpụtara mgbanwe mgbanwe nke ọrịa, ịbelata Liptonorm ka ọ belata ma ọ bụ kwụsịchaa ị intụ ya kpamkpam.

Tupu ịkọwa ọgwụ ahụ, mgbe ahụ izu isii na izu iri na abụọ ka ịmalite ọgwụgwọ gasịrị, mgbe ọ bụla na-abawanye ọgwụ, yana oge niile n'oge usoro ọgwụgwọ (dịka ọmụmaatụ, ọnwa 6 ọ bụla), a ga-enyocha ọrụ imeju. A na-ahụkarị mgbanwe n’ọrụ enzyme n’ime ọnwa atọ ndị mbụ ewere Liptonorm. N'ihe banyere mmụba nke ọgwụ hepatic, ndị ọrịa kwesịrị ịnọ n'okpuru nlekọta ahụike ruo mgbe eweghachitere ndị na-egosi ihe. Ọ bụrụ na uru nke alanine aminotransferase (ALT) ma ọ bụ aspartate aminotransferase (AST) karịrị ugboro atọ karịa otu uru ahụ maka hyrenplasia adrenal hyperplasia, a na-atụ aro ka ibelata dose ma ọ bụ kwụsị ọgwụ.

Ọ dị mkpa iji tụọ uru a tụrụ anya ya na ogo ihe ọghọm ma ọ bụrụ na ọ dị mkpa iji jikwa Liptonorm na onye ọrịa na-anata cyclosporine, erythromycin, clarithromycin, immunosuppressants, ọgwụ fibroic acid, nicotinic acid (na usoro onyonyo nwere mmetụta dị ala), ndị na-ahụ maka ihe mgbochi bụ ndị azoleeri. Ọ bụrụ na enwere ihe ịrịba ama nke mgbu akwara, adịghị ike, ma ọ bụ ike ọgwụgwụ, ọkachasị n'oge ọnwa ole na ole mbụ nke ọgwụgwọ ma ọ bụ na mmụba na ụdị ọgwụ ọ bụla, a ga-eji nlezianya nyochaa ọnọdụ onye ọrịa ahụ.

Ọ bụrụ na enwere ihe ndị dị ize ndụ maka mmepe nke nnukwu akwara ọdịda dị ka nsonaazụ rhabdomyolysis (dịka ọmụmaatụ, hypotension arterial, nnukwu metabolic na ọrịa endocrine, nnukwu ọrịa, trauma, ịwa ahụ buru ibu, elektrolyte), yana n'ihe banyere ọnọdụ siri ike nke nwere ike igosi. mmepe nke myopathy, Liptonorm ga-abụrịrị nwa oge ma ọ bụ kwụsịchapụrụ kpamkpam.

E kwesịrị ịdọ onye ọrịa ọdụ gbasara ịchọrọ ịkpọtụrụ dọkịta ozugbo ma ọ bụrụ na ị na-enwe adịghị ike ma ọ bụ mgbu mgbu na-enweghị nkọwa, yana ọkachasị ma ọ bụrụ na ọnya na / ma ọ bụ fever na-esonyere gị

Enweghị akụkọ ọ bụla banyere mmetụta ọjọọ Liptonorm na ikike ịkwọ ụgbọala na ịrụ ọrụ chọrọ nlebara anya.

Mkparịta ụka ọgwụ ọjọọ

Immunosuppressants, ndị ọrụ antifungal na-esite na azole, fibrates, cyclosporine, erythromycin, clarithromycin, nicotinamide na-abawanye itinye uche nke atorvastatin na plasma ọbara na ihe ize ndụ nke ịmalite myopathy.

Ọkwa ihe eji arụ ọrụ Liptonorm bukwara site na ndị na - egbochi CYP3A4.

Ihe anakpo Antacids belata mkpocha nke atorvastatin site na 35%, mana anaghị emetụta ọdịnaya cholesterol dị obere lipoproteins dị ala.

Mgbe ị na-ewere Liptonorm kwa ụbọchị nke 80 mg n'otu oge na digoxin, ịta nke ikpeazụ na ọbara na-abawanye ihe dịka 20%.

Liptonorm, nke a na-ewere kwa ụbọchị nke 80 mg, na-eme ka mmụba nke ọgwụ mgbochi ọnụ nke nwere ethinyl estradiol ma ọ bụ norethidrone site na 20%.

Mmetụta hypolipPs nke njikọta nke atorvastatin na colestipol dị elu karịa nsonaazụ dị na ọgwụ ọ bụla n'otu n'otu.

N'ihe banyere ojiji nke warfarin na ụbọchị mbụ nke ọgwụgwọ, oge prothrombin na-ebelata, ma mgbe ụbọchị iri na ise gasịrị, ihe ngosi a, dịka iwu, na-agbanwe. Maka nke a, ndị ọrịa na-anata otu ụdị ahụ kwesịrị ịchịkwa oge prothrombin karịa oge mbụ.

N'oge ọgwụgwọ, a naghị atụ aro ka ọ consumeụọ mmiri mkpụrụ osisi grape, ebe ọ nwere ike inye aka mee ka mkpokọta atorvastatin dị na plasma ọbara.