Etu ị ga-esi jiri ọgwụ Tritace Plus mee ihe?

Mlọ ọgwụ Ramiprilat, metabolism nke ramipril na-arụ ọrụ, na-egbochi enzyme dipeptidyl carboxypeptidase I (okwu: angiotensin na-agbanwe enzyme, kininase II). Na plasma na anụ ahụ, enzyme a na - eme ka ntụgharị nke angiotensin nke m gbanwee bụrụ ihe na - arụ ọrụ nke vasoconstrictor (vasoconstrictor) angiotensin II, yana ndakpọ nke vasodilator bradykinin. Mbelata okike nke angiotensin II na igbochi ndakpọ nke bradykinin na-eduga n'ịbawanye akwara nke ọbara.
Ebe ọ bụ na angiotensin nke abụọ na - akpalite mwepụta nke aldosterone, a na - ebelata nzuzo nke aldosterone n'ihi ramiprilat. Mmụba nke ọrụ bradykinin, doro anya, na-ekpebi cardioprotective na endothelioprotective mmetụta nke a hụrụ na nyocha anụmanụ. Taa, e guzobeghi etu nke a si emetụta ntinye nke mmetụta ụfọdụ (dịka ọmụmaatụ, ụkwara na-ewe iwe).
Ndị na - egbochi ACE dị irè ọbụna maka ndị ọrịa nwere ọbara mgbali elu, bụ mgbe mgbakwunye nke renin na plasma ọbara dị ala. Nzaghachi nkezi nke ACE inhibitor monotherapy na ndị ọrịa nwere agbụrụ Negroid (na-abụkarị na ọnụ ọgụgụ ndị nwere ọbara mgbali elu na ntinye uche dị ala) dị ala ma e jiri ya tụnyere ndị nnọchi nke agbụrụ ndị ọzọ.
Iwere ramipril na-ebute mbelata nke ukwuu na nguzogide akwara ọgụ. Na mkpokọta, plasma na-asọba na sel zuru ụwa ọnụ na-agbanwe agbanwe anaghị agbanwe agbanwe.
Mmeghe nke ramipril na ndị ọrịa nwere ọbara mgbali elu na-eduga na mbelata ọbara mgbali elu na supine na ọnọdụ iguzosi ike, na-enweghị uto na ọnụego obi.
N’ọtụtụ ndị ọrịa, ọgwụ antihypertensive mgbe a jisịrị ọnụ nke nchịkwa otu na-apụta mgbe awa 1-2. Ọ na-abụkarị nsonaazụ otu pacenti gachara awa 3 ruo 6 ma ọ na-anọkarị awa iri abụọ na anọ.
Mmetụta antihypertensive kachasị na ọgwụgwọ ogologo oge ya na ramipril bụ mgbe ahuru ka izu 3-4 gachara. E kpughere ya na iji ọgwụ ogologo oge ọ na-adịgide ruo afọ 2.
Na nzaghachi na mwepu nke ramipril na-abaghị uru, ọnweghị ọbara mgbali ngwa ngwa ma kwupụta ọkwa.
Ọmụmụ AIRE gosipụtara na n'ime ndị ọrịa nwere ngosipụta nke ọrịa nke nkụda obi, ọgwụgwọ nke malitere ụbọchị 3 ruo 10 mgbe nnukwu myocardial infarction, ramipril belatara ohere nke ọnwụ na 27% ma e jiri ya tụnyere placebo. Subanalysis kpughere mbelata ihe egwu ndị ọzọ, gụnyere ihe ọghọm nke ọnwụ na mberede (site na 30%) yana ihe ọghọm nke ọrịa na-ebute mmepe nke nnukwu obi obi na-adịgide (site na 23%). Na mgbakwunye, olile anya ụlọ ọgwụ emesia n'ihi nkụchi obi dara jiri 26% belata.
N'ime ndị ọrịa na-arịa ọrịa mamịrị ma ọ bụ nephropathy na-arịa ọrịa mamịrị, ramipril na-ebelata ọnụego ọganihu nke ọdịda akụrụngwa na mmalite ọdịda gbasara akụrụngwa ọgwụgwụ, yana n'ihi nke a, ọ dị mkpa ka a na-egbu ya ma ọ bụ na-emegharị akụrụ. N'ime ndị ọrịa na-arịa ọrịa shuga mbụ na-arịa ọrịa mamịrị ma ọ bụ nke ọrịa mamịrị, ramipril na-ebelata excursion albumin.
Ọmụmụ HOPE ebe a na - achịkwa ọgwụ (Nsonaazụ Nnwale Mgbochi Ọgụgụ Obi), nke were afọ 5, gụnyere ndị ọrịa dị afọ 55 gbagowe bụ ndị nwere nnukwu ọrịa obi n'ihi ọrịa vaskụla. (dịka oria akwara akwara dị adị, akụkọ ihe mere eme nke ọrịa strok ma ọ bụ ọrịa vaskụla ụkwara ala) ma ọ bụ ọrịa shuga, nwere opekata mpe otu ihe ọzọ dị egwu (microalbuminuria, ọbara mgbali elu, oke ọkwa izugbe. Cholesterol, cholesterol HDL dị ala, na-ese anwụrụ). Ndị ọrịa 4645 gbakwunyere usoro ọkọlọtọ ejiri ramipril mee ihe maka ebumnuche prophylactic. Ihe omumu a gosiputara na ramipril, nke nwere onu omuma di elu, belatara oria myocardial infarction, strok, ma obu onwonye obi. Na mgbakwunye, ramipril na-ebelata oke onwu na mbilite nke mkpa ịlọ ụwa, ọ na-egbu oge ịmalite na ngụgụ nke nkụda mmụọ obi. Ramipril na-ebelata ihe ize ndụ nke ịmalite ọrịa nephropathy na ọha mmadụ na ndị ọrịa nwere ọrịa shuga. Ramipril na-ebelata oke nke microalbuminuria. A hụrụ mmetụta dị otú ahụ na ndị ọrịa nwere ma ọ bụ ọbara mgbali elu na normotension.
Mlọ ọgwụ A metabolism usoro nke prodrug, ramipril, na-eme na imeju, n'ihi nke nke na-arụ ọrụ metabolite ramiprilat (site hydrolysis, nke na-adịkarị na imeju). Na mgbakwunye na mmegharị dị otú ahụ na ịmepụta ramiprilat, ramipril na-enwe glucuronidation ma gbanwee ghọọ ramipril diketopiperazine (ether). Ramiprilat bụkwa glucuronidated ma gbanwee ya na ramiprilat diketopiperazine (acid).
N'ihi nsị / metabolization nke prodrug a, ihe dị ka 20% nke ramipril nke a na-eji ọnụ na-ahụ.
Ihe bioavailability nke ramiprilat mgbe nchịkwa ọnụ nke 2.5 na 5 mg nke ramipril bụ ihe dị ka 45%, ma e jiri ya tụnyere mgbe nchịkwa iv nke otu usoro ọgwụgwọ.
Mgbe nchịkwa ọnụ nke 10 mg nke ramipril nke akara akara, ihe dịka 40% nke aha ahụ niile ka etinyere na feces na ihe dịka 60% na mmamịrị ahụ. Mgbe nchịkwa ọnụ nke 5 mg nke ramipril nye ndị ọrịa nwere mmiri mmerụ ahụ, ihe dị ka ramipril na metabolites ya na-adị na awa 24 ka mbu nwere mmamịrị na bile.
Ihe dị ka 80 ruo 90% nke metabolites dị na mmamịrị na bile bụ ramiprilat ma ọ bụ ramiprilat metabolites. Ramipril glucuronide na ramipril diketopiperazine na-ewe ihe dị ka 10 ruo 20% nke mkpokọta ahụ, na ramipril na-enweghị nchebe dị ihe dị ka 2%.
N'ime ọmụmụ anụmanụ, ramipril achọpụtara ka ọ na-abanye na mmiri ara.
Ramipril na-abanye ngwa ngwa mgbe nchịkwa ọnụ gasịrị. Dika emere ka o guzosie ike site na itule ego nke ihe na-eme ka ogha n’iru n’ime mmamiri, nke na-egosiputa otu n’ime uzo isi ewepu, nnabata ramipril erughi 56%. Iwere ramipril na nri ekpughere nnukwu mmetụta na mmiri.
A na-enweta mkpo plasma kachasị nke ramipril 1 awa mgbe nchịkwa ọnụ. Ọkara ndụ nke ramipril dị ihe dị ka awa 1. A na-ahụkarị mkpụmkpụ nke ramiprilat na plasma n'etiti awa 2 na 4 mgbe nchịkwa ọnụ nke ramipril gasịrị.
Mbelata nke ịta nke ramiprilat na plasma na-apụta n'ọtụtụ usoro. Oge mbu nke nkesa mbu na mkpochapu dika ihe dika awa 3. Mgbe nke a gasiri, enwere mgbanwe mgbanwe (ya na ihe dika ihe dika ihe dika awa iri na ise), emesia oge ikpe azu, oge eji eme ka plasma nke ramiprilat di ala, na oge ihe dika ubochi 4-5.
Ọnụnọ nke usoro ikpeazụ n'ihi ntakịrị nke ramiprilat ngwa ngwa site na mmekọrịta chiri anya, kama, enwere mmekọrịta na ACE.
Na agbanyeghi ogologo mkpochapu ikpeazụ, mgbe otu ramipril jiri otu mgali 2.5 ma ọ bụ karịa, ọnọdụ kwụ ọtọ (mgbe plasma ịta ahụhụ nke ramiprilat na-adịgide) mgbe ihe dị ka ụbọchị anọ gachara. Mgbe ọ gbasasịrị ugboro ugboro, ndụ ọkara ahụ dị irè, dabere na dose ahụ, bụ elekere 13-17.
Nnyocha ọmụmụ vitro egosila na mgbochi nke ramiprilat bụ 7 mmol / L, na oge nnupụisi nke ramiprilat na ACE bụ awa 10.7, nke na-egosi ọrụ dị elu.
Njikọ ramipril na ramiprilat na protein protein dị ihe dịka 73 na 56%, otu isi.
N'ime ndị ahụ dị afọ 65-76 na afọ, kaetik nke ramipril na ramiprilat yiri nke ahụ na ndị ahụ dị afọ iri na ụma.
Site na arụmọrụ gbasara akụrụ arụrụala, mwepu nke ramiprilat site na akụrụ na-ebelata, nwezịpụrụ akwara nke ramiprilat na-agbadata na ogo nke njigide creatinine. Nke a na-ebute mmụba nke plasma nke ramiprilat, nke na-agbada nwayọ nwayọ karịa ndị mmadụ nwere ọrụ ezumike nkịtị.
Site na ntinye nke usoro onyonyo dị elu (10 mg) yana mbelata ọrụ imeju, ntụgharị nke ramipril gaa ramiprilat na-emecha, mgbanye plasma nke ramipril na-abawanye na mpụta nke ramiprilat na-ebelata.
Dịka ọ dị na ndị mmadụ nwere ahụike na ndị ọrịa nwere ọbara ọgbụgba, mgbe ọnụ a na-achịkwa 5 mg nke ramipril otu ugboro kwa izu maka izu abụọ na ndị ọrịa nwere mkpọda obi, enweghi nnukwu nchịkọta nke ramipril na ramiprilat.
Ihe nchekwa nchekwa nke ime. Nsonaazụ nke nnwale ọ bụla gosiri na enweghị ihe egwu ọ bụla na mmadụ dabere n'ọmụmụ ihe ọmụmụ gbasara nchekwa ọgwụ, nsí na oke onunu, genotoxicity, carcinogenicity.

Ihe ngosiputa maka iji ọgwụ Tritace

AH (ọbara mgbali elu), na ebumnuche nke iwetulata ọbara mgbali elu dị ka monotherapy ma ọ bụ na njikọta ndị ọzọ antihypertensive, dịka ọmụmaatụ, diuretics na ndị na-emegide calcium.
Ọrịa obi na-eme mkpọtụ, yana njikọ ya na akwara.
Ọkpụkpụ obi na -akpata n'ime ụbọchị ole na ole mbụ ọ rịsịrị nnukwu ọrịa myocardial infarction.
Ọrịa mamịrị ma ọ bụ ọrịa mamịrị ma ọ bụ ọrịa mamịrị ma ọ bụ nephropathy mbụ.
Mbelata ihe ize ndụ nke infarction myocardial, ọrịa strok, ma ọ bụ ọnwụ obi na ndị ọrịa nwere nnukwu ọrịa obi n'ihi ọrịa obi na-arịa (na ma ọ bụ na-enweghị myocardial infarction), ọrịa strok, akụkọ ihe mere eme nke ọrịa vaskụla, ma ọ bụ ọrịa shuga mellitus nwere opekata mpe otu ihe. ihe egwu vaskụla (microalbuminuria, ọbara mgbali elu, cholesterol dị elu, cholesterol HDL dị ala, ise anwụrụ).

Ojiji nke ọgwụ Tritace

A na-ekpebi usoro ọgwụgwọ ahụ dabere na ntinye ọgwụ a nyere ndị ọrịa akọwapụtara.
A ga-eji mmiri mmiri were mmiri (were ihe dị ka iko 1/2) were were mbadamba Tritace. Mbadamba ekwesighi-ata ata ma ọ bụ gwepịa ya.
Ihe oriri adịghị emetụta mmịpụta nke ramipril. Ya mere, enwere ike ibute Tritace tupu, tupu nri ma ọ bụ mgbe e risịrị nri.
Ọgwụ ọbara mgbali elu (ọbara mgbali elu).
Usoro akwadoro ịmalite maka ndị okenye: 2.5 mg Tritace otu ugboro n'ụbọchị.
Dabere na nzaghachi nke onye ọrịa ahụ, enwere ike ịbawanye dose ahụ. A na-atụ aro ka iwelie dose ahụ site na ị na-atụgharị ya kwa izu abụọ ọ bụla.
Maintenancegwọ mmezi a na-adịkarị: 2.5 na 5 mg Tritace kwa ụbọchị.
Ikike dị ukwuu maka ndị okenye kwa ụbọchị: 10 mg Tritace.
Ihe ozo maka ịbawanye ogwu nke ihe kariri 5 mg nke Tritace kwa ụbọchị nwere ike ịbụ ojiji ọzọ, dịka ọmụmaatụ, diuretic ma ọ bụ calcium antagonist.
Ọgwụgwọ ọrịa obi ọgụ.
Usoro akwadoro ịmalite maka ndị okenye: 1.25 mg Tritace 1 oge kwa ụbọchị.
Dabere na nzaghachi onye ọrịa ahụ, enwere ike ịbawanye ọgwụ ahụ site na ị na-atụgharị ya kwa izu 1-2 ọ bụla. Ọ bụrụ na ọgwụ achọrọ bụ 2.5 mg nke Tritace ma ọ bụ karịa, enwere ike iwere ya otu ọgwụ ma ọ bụ ekewa abụọ.
Ikike kachasị kwa ụbọchị: 10 mg Tritace.
Ọgwụgwọ mgbe infarction myocardial.
Usoro akwadoro ịmalite: 5 mg Tritace kwa ụbọchị, kewara abụọ n'ime 2,5 mg, a na-ewere otu ọgwụ n'ụtụtụ na nke ọzọ na mgbede. Ọ bụrụ na onye ọrịa ahụ anabataghị usoro ọgwụgwọ mbụ ahụ, a na-atụ aro ka ọ were ọgwụ 1.25 mg ugboro abụọ kwa ụbọchị maka ụbọchị 2.
Mgbe ahụ, dabere na nzaghachi nke onye ọrịa ahụ, enwere ike ịbawanye dose ahụ. Ọ na-atụ aro ka iwelie dose ahụ site na ị na-atụgharị ya kwa ụbọchị 1 ruo 3.
N’ọ n’i n’ihu, enwere ike ị takenụkọta ego otu ugboro kwa ụbọchị, nke bu ụzọ kewaa abụọ, a ga-ewere otu otu.
Ikike kachasị kwa ụbọchị: 10 mg Tritace.
Ahụmịhe n’imeso ndị ọrịa nwere ọrịa siri ike (klas IV, NYHA - New York Heart Association) nkụda mmụọ obi ozugbo infarction myocardial ezughi. N'ihe banyere iji ọgwụ Tritace mee ihe, a na-atụ aro ịmalite usoro ọgwụgwọ site na iji ọgwụ kachasị dị ala kwa ụbọchị (1.25 mg nke Tritace otu ugboro kwa ụbọchị) na mmụba ọ bụla ga-esochi ya kwesịrị iji nlezianya buru ibu.
Ọgwụ nke nephropathy na-arịa ọrịa mamịrị ma ọ bụ ọrịa mamịrị.
Usoro akwadoro ịmalite maka ndị okenye: 1.25 mg Tritace 1 oge kwa ụbọchị.
Dabere na ndidi onye ọrịa ị drugụ ọgwụ, enwere ike ịbawanye dose ahụ ka ọ bụrụ mmezi ya, nke bụ 5 mg nke Tritace 1 oge kwa ụbọchị.
Usoro ọgwụgwọ dị karịa 5 mg nke Tritace otu ugboro n'ụbọchị agụghị akwụkwọ nke ọma n'oge ule ụlọ ọgwụ na-achịkwa.
Iji belata ihe ọgbụgba myocardial infarction, ọrịa strok, ma ọ bụ ọnwụ obi.
Usoro akwadoro ịmalite maka ndị okenye: 2.5 mg Tritace 1 oge kwa ụbọchị.
Dabere na ndidi onye ọrịa ị drugụ ọgwụ, enwere ike ịba ụba nke ọgwụ ahụ. Ọ na-atụ aro ka ịgbanye okpukpu abụọ mgbe ọgwụgwọ izu 1 gachara, ma ka izu atọ gachara - mụbaa ya ka ọ dị na mbụ mmezi nke 10 mg Tritace otu ugboro n'ụbọchị.
N'ime ule ụlọ ọgwụ a na-achịkwa, ojiji nke iji ihe karịrị 10 mg nke Tritace otu ugboro n'ụbọchị agụghị akwụkwọ zuru ezu.
Agụbeghị ndị ọrịa nwere nnukwu akụrụ siri ike na mkpochapụ creatinine nke ≤36 ml / min nke ọma.
Onu ogugu ndi mmadu puru iche.
Ndị ọrịa nwere ọrụ mgbazinye nsogbu.
Ọ bụrụ na nkọcha nke creatinine bụ 50-20 ml / min kwa 1.73 m 2 nke akụkụ ahụ dị elu, a na-ejikarị ọgwụ okenye nke kwa ụbọchị nke 1.25 mg nke Tritace. Oke kachasị kwa ụbọchị na nke a bụ 5 mg Tritace.
Ndị ọrịa nwere ahụghịzi elektrọnte ahụ, ndị ọrịa nwere nnukwu ọbara ọgbụgba (mgbali elu akwara), yana ndị ọrịa maka mmeghachi omume hypotensive nwere ike ibute otu ihe atụ (dịka ọmụmaatụ, na-enwe nnukwu ogosi ike nke akwara ọbara ma ọ bụ arịa ụbụrụ, a ga-eji obere mbido mbụ belata 1 , 25 mg Tritace kwa ụbọchị.
A na-agwọ ndị ọrịa ọrịa nkwarụ na mbụ.
Ọ dị mma ịkwụsị ị diụ ọgwụ mkpụrụ ụbọchị abụọ ruo ụbọchị atọ ma ọ bụ, dabere na oge ihe ndị diuretic ahụ mere, ọbụlagodi tupu ịmalite ọgwụgwọ na Tritace, ma ọ bụ opekata mpe belata ọgwụ nke diuretic ahụ. Ọgwụ nke ụbọchị mbụ maka ndị ọrịa okenye jibu ọrịa ịba ọcha n'anya na-abụkarị 1.25 mg Tritace.
Ndị ọrịa nwere ọria imeju.
Enwere ike ịbawanye azịza nke ọgwụgwọ ma ọ bụ belata. Ya mere, ekwesịrị ịmalite usoro ọgwụgwọ ndị ọrịa n'okpuru nlekọta ahụike siri ike. Ọgwụ kachasị maka ndị okenye bụ 2.5 mg Tritace.
Ndị okenye.
Ọgwụ nke mbụ kwesịrị ịdị obere - 1.25 mg Tritace kwa ụbọchị.

Ihe mgbochi iji ọgwụ Tritace

hypersensitivity na ramipril, ihe mgbochi ACE ọzọ ma ọ bụ nke ọ bụla na ndị mejupụtara ọgwụ ahụ,
Akụkọ banyere anakpoede,
stalosis akụrụngwa (akwara ma ọ bụ akwara akwara)
Ọnọdụ ejikọtara ọnụ ma ọ bụ nke ejighi ọnọdụ ya,
hyperaldosteronism,
oge ime
oge lactation
afọ ụmụaka.

Zere iji Tritace ma ọ bụ ihe ndị ọzọ ACE na-egbochi yana usoro ọgwụgwọ extracorporeal, nke nwere ike ibute kọntaktị ọbara na mbara ihu ndị na-adịghị mma, ebe ọ bụ na enwere ihe egwu nke mmeghachi omume anaphylactoid, nke nwere ike ibute oke nsogbu anaphylactic.
Ya mere, mgbe ị na-ewere Tritace, ọ gaghị ekwe omume iji usoro nhicha ọbara ma ọ bụ usoro iji gosipụta usoro ọgwụgwọ ahụ ma ọ bụ usoro ịwa ahụ ọkụ, iji sodium-2-methylsulfonate membranes na-egosipụta ike dị elu (dịka ọmụmaatụ, "AN 69") na usoro apheresis LDL site na iji dextran sulfate.

Nsonaazụ nke ọgwụ Tritace

Ebe ọ bụ na Tritace bụ ọgwụ na - egbochi ọgwụ, ọtụtụ n'ime ihe ndị ọ na - arụpụta na - esote ya na - ebilite ebumnuche ya, na - ebute mgbakwunye adrenergic ma ọ bụ hypoperfusion akụkụ. Ọtụtụ mmetụta ndị ọzọ (dịka ọmụmaatụ, mmetụta na nguzozi nke electrolytes, ụfọdụ anaphylactoid ma ọ bụ mmeghachi omume mkpali sitere na akpụkpọ ahụ mucous) na-akpata site na mgbochi ACE ma ọ bụ mmetụta ọgwụ ndị ọzọ na klas a.
Usoro akwara na akwara.
N’oge na-adịghị anya, mgbaàmà dị nro na mmeghachi omume nwere ike ime, dịka isi ọwụwa, enweghị isi, tachycardia, adịghị ike, iro ụra, ibu iwe, ma ọ bụ mbelata nke mmeghachi omume.
Mmeghachi omume nrịanrịa na ihe mgbaàmà, dịka akwara akụkụ, ịpụpụ, ọgbụgbọ, tinnitus, ike ọgwụgwụ, ahụ erughị ala, nkụda mmụọ, oke ụjọ, nchekasị, ọhụhụ, nsogbu ụra, ọgba aghara, nchekasị, ịgafe dysfunction, mmetụta ọrịa palpitations, ọsụsọ gabigara ókè, imerụ ntị, ụra ụra, iwu orthostatic, yana mmeghachi omume siri ike dịka angina pectoris, ihe gbasara obi na enweghị mwepụ na - adịghị ahụkebe.
Ọrịa hypotension siri ike anaghị adịkarị, ischemia myocardial ma ọ bụ nke akụkụ ụbụrụ, myocardial infarction, mkpirikpi ischemic ọgụ, ischemic stroke, exacerbation of circulatory disturbances by vaskụla stenosis, na-akawanye njọ ngosipụta nke ihe ịtụnanya Raynaud ma ọ bụ paresthesia ka a hụrụ n'ọnọdụ ndị dịpụrụ adịpụ.
Akụrụ na itule electrolyte.
Mgbe ụfọdụ enwere mmụba na urea na serum creatinine (ihe gbasara nke puru omume na-abawanye site na iji mgbatị ndị ọzọ) na ịda mba na ọrụ akụrụ, n'ọnọdụ ndị dịpụrụ adịpụ enwere ike ibido - mmepe nke nnukwu gbasara akụrụ.
Mgbe ufodu, itinye nkpuru ahihia karia karia. N'ọnọdụ ndị dịpụrụ adịpụ, ọkwa sodium serum nwere ike ibelata, yana proteinuria dị adị nwere ike ịbawanye (n'agbanyeghị eziokwu ahụ na ndị na-egbochi ACE na-edugakarị na proteinuria) ma ọ bụ mmụba na mmamịrị (n'ihi ọrụ ọria obi dị mma).
Usoro iku ume, anaphylactic / anaphylactoid na mmeghachi omume anụ ahụ.
Oge ụfọdụ nwere ụkwara akpọnwụ akpọnwụ (na-enweghị mkpụrụ). Ukwara nta a na-akawanye njọ n’abali na mgbe ezumike (dịka ọmụmaatụ, ebe dina ala), ihe na - apụtakarị na ụmụ nwanyị na ndị anaghị a smokeụ sịga.
N’oge na-adịghị anya, mkpọchi imi, sinusitis, bronchitis, bronchospasm, na dyspnea na-etolite.
N’oge na-adịghị anya, enwere ike ịhụ ọrịa angioneurotic edema (angioedema nke ndị na-egbochi ACE na-eme ọtụtụ oge na ndị ọrịa nke agbụrụ Negroid ma e jiri ya tụnyere ndị ọrịa nke agbụrụ ndị ọzọ). Mmeghachi mmetụta siri ike nke ụdị a na ọgwụ anaphylactic ndị ọzọ na-abụghị ọgwụ ọgwụ, ma ọ bụ mmeghachi omume anaphylactoid na ramipril ma ọ bụ ihe ọ bụla ọzọ dị ụkọ.
Mmeghachi omume si anụ ahụ ma ọ bụ akpụkpọ anụ mucous, dị ka ihe nchapu, itching, ma ọ bụ hives adịghị adị. N'ọnọdụ ndị na-adịghị ahụkebe, ọnya nke ọdịdị anụ ahụ machibpapular, pemphigus, njọ nke psoriasis, psoriasiform, pemphigoid ma ọ bụ lichenoid exanthema na enanthema, erythema multiforme, Stevens-Johnson syndrome, necrolysis na-egbu egbu, alopecia, onycholysis ma ọ bụ photocholism nwere ike.
Ohere nwere ike ịdapụta na nhụsianya nke ihe anaphylactic na mmeghachi omume anaphylactoid na venom ahụhụ n'oge mgbochi ACE na-abawanye. Ekwenyere na enwere ike ịhụ mmetụta dị otú ahụ na-emetụta nza ndị ọzọ.
Ọkpụkpụ afọ, imeju.
N’oge na-adịghị anya, ọgbụgbọ, mmụba nke ọkwa enzymes nke imeju na / ma ọ bụ bilirubin, yana ọrịa jaundice, nwere ike ime. Oge ụfọdụ, akpọnwụ akpọnwụ, ihe mgbochi, afọ erughị ala, mgbu epigastric, iwe nri, afọ ntachi, afọ ọsịsa, vomiting, na ịba ụba enzymes pancreatic. N'ọnọdụ ndị dịpụrụ adịpụ, ọrịa pancreatitis ma ọ bụ mmebi imeju (gụnyere nnukwu ọrịa imeju).
Mmeghachi omume Hematologic.
Oge ụfọdụ, enwere ike inwe obere - n'ọnọdụ ụfọdụ dị mkpa - belata ọnụ ọgụgụ mkpụrụ ndụ ọbara uhie na haemoglobin, ọnụ ọgụgụ mkpụrụ ndụ ọbara ọcha ma ọ bụ platelet. N'ọnọdụ ndị dịpụrụ adịpụ, a na-ahụkarị agranulocytosis, pancytopenia na ụmị ọkpụkpụ.
Mmeghachi omume hematological maka ihe ACE inhibitors na-emekarị na ndị ọrịa nwere ọrụ gbasara akụrụngwa na-arụ ọrụ, ọkachasị yana congenites collagenoses (dịka ọmụmaatụ, systemic lupus erythematosus ma ọ bụ scleroderma), ma ọ bụ na ndị ọrịa na-eji ọgwụ ndị ọzọ nwere ike ime ka mgbanwe na nhazi nke ọbara.
N'ọnọdụ ndị dịpụrụ adịpụ, ọbara ọgbụgba hemolytic nwere ike ịmalite.
Nsonaazụ ndị ọzọ.
N’oge na-adịghị anya, conjunctivitis nwere ike ime, yana oge ụfọdụ na-emegharị ahụ, na-ebelata libido, enweghị agụụ na isi na-egbu (dịka ọmụmaatụ, ụtọ dị n’ime ọnụ) ma ọ bụ na-ele mmadụ anya n’ihu, mgbe ụfọdụ, ihe na-efunahụ ya.
N'ọnọdụ ndị dịpụrụ adịpụ, a hụrụ vasculitis, myalgia, ogbu na nkwonkwo, ahụ ọkụ na eosinophilia, yana mmụba n'ọnụ ọgụgụ nke ọgwụ antiinclear.

Ntụziaka pụrụ iche maka iji ọgwụ Tritace mee ihe

Ekwesịrị iji tritace mee ihe n'okpuru nlekọta nke dọkịta.
N'ime ndị ọrịa mesoro ndị na-egbochi ACE, a hụrụ ntụgharị ihu nke ihu, aka, egbugbere ọnụ, ire, glottis ma ọ bụ pharynx. Ọgwụgwọ mberede maka angioedema na-eyi ndụ egwu gụnyere nchịkwa nke epinephrine ozugbo (sc ma ọ bụ nwayọ iv) n’usoro ECG na njikwa ọbara mgbali. A na-atụ aro ịgba ọgwụ n'ụlọ ọgwụ, na-elebara onye ọrịa anya ma ọ dịkarịa ala awa iri na abụọ ruo 24, ruo mgbe ihe mgbaàmà na-apụ n'anya kpamkpam.
N'ime ndị ọrịa mesoro ndị na - egbochi ACE, a hụrụ ihe banyere angioedema nke eriri afọ. Ndị ọrịa a mere mkpesa nke mgbu afọ (ya na ma ọ bụ na ọ bụ ọgbụgba ma ọ bụ ọgbụgbọ), na n'ọnọdụ ụfọdụ angioedema nke ihu mekwara. Ọrịa angioedema nke eriri afọ kwụsịrị mgbe ọ kwụsịrị ihe mgbochi ACE.
Enweghi ahụmịhe ọgwụgwọ zuru oke na Tritace maka ụmụaka, ndị ọrịa nwere nnukwu akụrụ oke (mwepụta creatinine n'okpuru 20 ml / min kwa 1.73 m2 nke mpaghara ahụ dị ala), yana ndị ọrịa nọ na mgbapụta.
Ndị ọrịa nwere nnukwu ọrụ nke sistemụ renin-angiotensin. N'ime usoro ọgwụgwọ nke ndị ọrịa nwere nnukwu ọrụ nke sistemụ renin-angiotensin, a ga-emerịrị nlekọta pụrụ iche. N'ime ndị ọrịa dị otu ahụ, enwere ihe ọghọm na mbelata ọbara mgbali na mberede na ọrụ ezigharị n'ihi mmachi ACE, ọkachasị mgbe etinyere ACE inhibitor ma ọ bụ concomitant diuretic na nke mbụ ma ọ bụ nke mbụ na ọnụọgụ dị elu. Ná mmalite nke ị drugụ ọgwụ ma ọ bụ na-abawanye na dose, a ga-eme nlezianya banyere ọbara mgbali ruo mgbe enwere ihe egwu nke mbelata ọbara mgbali elu.
Enwere ike ịtụ anya ọrụ na-arịwanye elu nke usoro renin-angiotensin, karịchaa:

n'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba. N'ime usoro ọgwụgwọ mbụ, achọrọ nlekọta ahụike pụrụ iche,
n’ebe ndị ọrịa nwere nnukwu nkụchi obi ma ọ bụ n’ihe banyere ọgwụ ndị ọzọ na-ebelata ọbara mgbali elu. Bụrụ na nkụda mmụọ siri ike n'oge mmalite nke ọgwụgwọ, nlekọta ahụike siri ike dị mkpa,
n'ime ndị ọrịa nwere nnukwu nsogbu n'ihe metụtara ọbara n'ọbara (dịka ọmụmaatụ, aortic stenosis ma ọ bụ mitral valve stenosis ma ọ bụ kadio hyprophic cardiomyopathy). N'ime usoro ọgwụgwọ mbụ, ịchọrọ nlekọta ahụike siri ike,
n'ime ndị ọrịa nwere ezigbo akwara akwara stenosis. N'ime usoro ọgwụgwọ mbụ, achọrọ nlekọta siri ike.

Ọ nwere ike ịdị mkpa ịkwụsị ọgwụgwọ amalite na diuretics:

n’ebe ndị ọrịa na-a tookụ ọgwụ na mbụ. Ọ bụrụ na ịkwụsị ma ọ bụ mbelata dose nke ọrịa ahụ agaghị ekwe omume, nlekọta ahụike siri ike dị mkpa na mmalite nke ọgwụgwọ,
n'ime ndị ọrịa nwere ihe iyi egwu ma ọ bụ enweghị ike na nguzozi electrolyte (n'ihi ezughị oke nke mmiri ma ọ bụ nnu, ma ọ bụ n'ihi ọnwụ ha - afọ ọsịsa, swab ma ọ bụ ọsụsọ dị ukwuu, n'ọnọdụ ebe ụgwọ maka enweghị mmiri na nnu ezughị ezu).

Mmezi nke steeti mmiri akpịrị, hypovolemia ma ọ bụ erughi electrolyte tupu ọgwụgwọ akwadoro (agbanyeghị, maka ndị ọrịa nwere nkụchi obi, a ga-eji nlezianya nyochaa usoro ndị ahụ idozi ihe banyere ohere enwere oke ibu). N'ọnọdụ dị oke mkpa nke ụlọ ọgwụ, enwere ike ịmalite ma ọ bụ gaa n'ihu ọgwụgwọ Tritace ka ọ na - eme ihe kwesịrị ekwesị iji gbochie mbelata ọbara mgbali elu na mbelata ọrụ ọrụ akụrụ.
Ndị ọrịa nwere ọria imeju.
N'ime ndị ọrịa nwere ọrụ imeju na-adịghị mma, nzaghachi maka ọgwụgwọ Tritace nwere ike ịbawanye elu ma ọ bụ belata. Na mgbakwunye, na ndị ọrịa nwere ọrịa imeju nke akwara na edema na / ma ọ bụ ascites, enwere ike ịbawanye ọrụ nke usoro renin-angiotensin, ya mere, a ga-elebara anya pụrụ iche n'oge ọgwụgwọ ndị ọrịa a.
Ndị ọrịa maka mbelata ọbara mgbali elu na-eweta otu ihe egwu (dịka ọmụmaatụ, ndị ọrịa nwere nnukwu ihe akwara nke akwara akwara akwara) ma ọ bụ arịa ụbụrụ dị mkpa, nlekọta ahụike siri ike dị mkpa na mmalite ọgwụgwọ.
Ndị agadi.
N'ime ndị agadi, mmeghachi omume na ndị na - egbochi ACE nwere ike ịkọ nkọ karịa. Ná mmalite nke ọgwụgwọ ha, a na-atụ aro maka nyocha maka ọrụ gbasara akụrụ.
Ọ na-atụ aro ka nyochaa ọrụ gbasara akụrụngwa, ọkachasị n'izu ndị mbụ yana onye na - egbochi ihe ACE. Nke kachasị nlebara anya dị mkpa maka ndị ọrịa nwere:

obi obara
ọrịa vasorenal, gụnyere ndị ọrịa nwere nnukwu akwara mkpọnwụ akwara stenosis. N'ime ndị otu ikpeazụ nke ndị ọrịa, ọbụlagodi ntakịrị ọkwa na serum creatinine nwere ike igosi mbelata ọrụ ọrụ akụrụngwa,
arụ ọrụ akụrụ,
ntụgharị akụrụ.

Nlekota uzo electrolyte.
A na-atụ aro ka a na -echebe ya mgbe niile gbasara ọgwụ potassium. Ọ dị mkpa ileba anya ugboro ugboro maka ọkwa ọgwụ serum n'ime ndị ọrịa nwere nsogbu ezumike ha na-arụ ya.
Hematologic nlekota.
A na-atụ aro inyocha ọnụ ọgụgụ nke leukocytes iji chọpụta oge leukopenia ga-ekwe omume. A na-atụ aro ka a na -emekwu nleba anya na usoro izizi nke ndị ọrịa nwere nsogbu gbasara akụrụ, ya na collagenosis (systemic lupus erythematosus ma ọ bụ scleroderma) ma ọ bụ ndị ọrịa na-anata ọgwụgwọ na ọgwụ ndị ọzọ na-emetụta ụkpụrụ hemogram.
Jiri n'oge ime na lactation.
N'ime oge ime ime, amachibidoro ị were Tritace (lee mpaghara NKWUKWU NSỌ). N'ihi ya, tupu ị theụ ọgwụ ọjọọ n'ime ụmụ nwanyị ịmụ nwa, ọ dị mkpa iwepu ime ọ ga-ekwe omume. Womenmụ nwanyị toro afọ kwesịrị iji ọgwụ mgbochi ndị a pụrụ ịdabere na ya mgbe ha na-ewere Tritace. Ọ bụrụ na nwanyị chọrọ ịtụrụ ime, kwụsịrị ị theụ ọgwụ ahụ wee were ọgwụ ọzọ dochie ya (ewezuga ndị mgbochi ACE). Ọ bụrụ na enweghị ike ịkwụsị ọgwụgwọ na ACE inhibitors, a ga-egbochi ime ime. N'ọnọdụ nke etinyere afọ ime n'oge ọgwụgwọ na Tritace, ọ dị mkpa ka ịgbanwee ngwa ngwa o kwere omume (n'okpuru nlekọta nke dọkịta) gaa na onye ọzọ na-ahụ maka ọrịa nke nwere ike ịdaba na nwa ebu n'afọ (ewepu ACE inhibitors).
Nnyocha ụmụ anụmanụ egosila na ramipril na-abanye n'ime mmiri ara. Ebe ọ bụ na amabeghị ma ramipril na-abanye na mmiri ara ara mmadụ, ojiji nke Tritace mgbe a na-enye nwa ara bụ nke imegide.
Childrenmụaka. N'ihi enweghị ahụmịhe ahụike zuru ezu, ekwesighi inye ụmụaka Tritace ọgwụ.
Ikike ime ka ọnụego mmeghachi omume dị mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ọrụ na usoro ndị ọzọ.Effectsfọdụ mmetụta nsonaazụ (dịka ọmụmaatụ, akara nke mbelata ọbara mgbali, ọkachasị ọgbụgbọ, ọgbụgbọ) nwere ike ibelata nlebara anya onye ọrịa na nzaghachi psychomotor.

Ọgwụ Mmekọrịta Ọgwụ

Njikọ ọnụ na-contraindicated.
Ofzọ nke ọgwụgwọ extracorporeal, nke na-ebute kọntaktị ọbara nwere ihe ndị na-adịghị mma ebubo, dị ka dialysis ma ọ bụ hemofiltration na-eji ụfọdụ membranes nwere oke ọnụọgụ (dịka ọmụmaatụ, polyacrylonitrile membranes) na Ldl apheresis site na iji dextrin sulfate.
Njikọ ọnụ na-anaghị akwadoro.
Nchịkwa nke potassium, sọlfọ na-agbapụta mkpụrụ osisi: mmụba nke ndọta potassium ga-atụ anya. Site na iji ọgwụgwọ n'otu oge na ramipril nwere ọgwụ drọọtin na-eme ka ọnụọgụ (dịka ọmụmaatụ, spironolactone) ma ọ bụ nnu nnu, ịkpachara anya nlebara anya nke potassium ịta ahụ dị mkpa.
Jiri ịkpachara anya.
Ọgwụ antihypertensive (dịka ọmụmaatụ diuretics) na ọgwụ ndị ọzọ nwere ike belata ọbara mgbali elu (dịka nitrates, tricyclic antidepressants, anesthetics): enwere ike ịtụ anya mmụba na antihypertensive mmetụta nke ramipril. Ọ na-atụ aro ka ị na-eleba anya n'ihe gbasara sodium n'ụka na ndị ọrịa na-anata ọgwụgwọ n'otu oge yana diuretics.
Vasoconstrictive sympathomimetics: nwere ike wedata nsonaazụ nke mbelata ọbara mgbali Tritace. A na-atụ aro iji nlezianya nyochaa ọbara mgbali karịsịa. Allopurinol, immunosuppressants, glucocorticosteroids, procainamide, cytostatics na ọgwụ ndị ọzọ nwere ike ibute mgbanwe na hemogram: nwere ike iwelie ohere nke mmeghachi omume hematological mgbe ejiri otu oge na ramipril.
Nnu nke lithium. Enwere ike belata mmiri nke lithium site na ndị na - egbochi ACE. Mbelata dị otú ahụ nwere ike ibute mmụba nke nsị lithium serum na mmụba na nsi lithium. N'akụkụ a, ọ dị mkpa ịchịkwa mkpo lithium n'ọbara ọbara.
Ndị ọrụ Antidiabetic (dịka ọmụmaatụ, insulin na usoro sulfonylurea). Ndị na - egbochi ACE nwere ike iwelie mmetụta nke insulin. N'ọnọdụ ụfọdụ, nke a nwere ike ibute mmepe nke hypoglycemia na ndị ọrịa na-ejikwa ọgwụ antidiabetic eme n'otu oge. Na mmalite ọgwụgwọ, a na-atụ aro iji nlezianya nke ọkwa glucose ọbara.
Ihe oriri anaghị agbanwe agbanwe mkpokọ mmiri ramipril.
Ekwesiri iburu n'uche.
NSAIDs (dịka ọmụmaatụ, indomethacin na acetylsalicylic acid). Ikekwe na-akụda nsonaazụ nke mbelata ọbara mgbali n'okpuru ọrụ Tritace. Na mgbakwunye, ọgwụgwọ n'otu oge na ACE inhibitors na NSAIDs nwere ike ibute oke ihe egwu nke ọrụ akụrụ belata yana ịba ụba ọkwa potassium.
Heparin. Ikekwe, mmụba na mkpokọta nke potassium n'ime ọbara ọbara.
Mmanya na-egbu egbu: na-abawanye vasodilation. Tritace nwere ike ime ka ihe mmanya na-egbu dịkwuo elu.
Nnu Saltba ụba nnu nwere ike imebi ihe mgbochi ọgwụ nke Tritace.
Ofzọ nke hyposensitization akọwapụtara. N'ihi mgbochi nke ACE, ohere na ogo nke anaphylactic na mmeghachi omume anaphylactoid na venom ahụhụ na-abawanye.A na-atụ aro na enwere ike ịhụ mmetụta dị otú ahụ na-emetụta nza ndị ọzọ.

Doụbiga ọgwụ ike Tritace, mgbaàmà na ọgwụgwọ

Ihe mgbaàmà nke ịxụbiga mmanya ókè. Dodoụbiga ihe ókè nwere ike ime ka akwara na-ebuwanye ibu (yana oke hypotension, ujo), bradycardia, enweghi ike itule ihe banyere ihe itule ihe na akuko.
Oụ ọgwụ mgbochi. Ntinye mmiri nke mbu, dịka ọmụmaatụ, site na ịsacha afọ, iji adsorbents, sodium thiosulfate (ọ bụrụ na ọ ga-ekwe omume, na nkeji iri atọ mbụ). N'ihe banyere hypotension, na mgbakwunye na nha iji weghachi olu mmiri na nguzozi nnu, ọ dị mkpa iji ndị agonist nke ndị nnabata α1-adrenergic (dịka ọmụmaatụ, norepinephrine, dopamine) ma ọ bụ angiotensin II (angiotensinamide), nke, dịka iwu, dị naanị na nyocha ndị mmadụ. ulo oru nyocha.
Onweghi data banyere ịdị irè nke diuresis a na-amanye, mgbanwe nke nzaghachi mmamịrị, ọnya ọbara ma ọ bụ usoro nke iji mee ka mkpochapu nke ramipril ma ọ bụ ramiprilat dị ngwa. Agbanyeghị, enwere ike ịtụle ọnya ọgbụgba ma ọ bụ nyocha ọbara ọbara.

Mpempe usoro onunu ogwu

Njirimara nke anụ ahụ na kemịkal:

Tritace PLUS ® 5 mg / 12.5 mg bụ mbadamba ihe na-acha pinki pinki pinki nwere akara na-akwụ ụgwọ n'akụkụ abụọ. Stampụ n’elu: 41 / AV.

Tritace PLUS ® 10 mg / 12.5 mg obulu oroma nwere oke nkewa na akuku ya. Stampụ 42 / AV.

Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ

Nri. Foodme nri n'otu oge anaghị emetụta nnabata nke ramipril.

Ofzọ nke ọgwụgwọ ọrịa extracorporeal, nke na - ebute ọbara nke nwere ihe ndị na - adịghị mma ebubo, dị ka dialysis ma ọ bụ hemofiltration site na iji membranes nwere oke ọnụọgụ (dịka ọmụmaatụ, polyacrylonitrile membranes) na apheresis nke obere lipoproteins dị ala site na iji dextran sulfate - nyere ohere nke ịbawanye ụba anaphylactic. mmeghachi omume (lee

Eji ọgwụ eji nwere aliskiren eme ọgwụ ka ejiri ya na ndị ọrịa nwere ọrịa shuga ma ọ bụ ndị ọrịa nwere nnukwu ọrụ mkpo ya.

A na - atụgharị ọgwụ maka angiotensin II antagonists na ọgwụ ọgwụ maka ndị ọrịa nwere nephropathy ọrịa shuga mana akwadoghị maka ndị ọrịa ndị ọzọ niile.

Mgwakọta chọrọ ịkpachapụ anya.

Nchịkwa nke potassium, heparin, potassium na-eme ka ọnụọgụ mmiri na ihe ndị ọzọ na-arụ ọrụ na-eme ka ọkwa potassium dị n'ọbara plasma (gụnyere angiotensin II antagonists, trimethoprim, tacrolimus, cyclosporine). Hyperkalemia nwere ike ime, yabụ ịkwesịrị iji nlezianya nyochaa ọkwa nke potassium na plasma ọbara.

Ọgwụ antihypertensive (dịka ọmụmaatụ diuretics) na ihe ndị ọzọ na - arụ ọrụ nke nwere ike belata ọbara mgbali (dịka nitrates, tricyclic antidepressants, anesthetics, mmanya, baclofen, alfuzosin, doxazosin, prazosin, tamsulosin, terazosin). Enwere ike ịbawanye n'ihe egwu nke hypotension (lee mpaghara “Usoro Ọgwụ na Nchịkwa” maka diuretics).

Vasopressor sympathomimetics na ihe ndị ọzọ na - arụ ọrụ (dịka eg epinephrine), nke nwere ike belata mmetụta antihypertensive nke ramipril. A na-atụ aro ka inyocha ọbara mgbali mgbe niile.

Allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics na ihe ndị ọzọ nwere ike ibute mgbanwe na foto ọbara. Likba ụba nke mmeghachi omume ọbara (lee akụkụ “atụmatụ nke ngwa”).

Nnu nke lithium. Ebe ọ bụ na ndị na - egbochi ACE nwere ike belata ikuku lithium, nke a nwere ike ibute mmụba nke nsị lithium.

Ndị ọrụ antidiedi, gụnyere insulin. Mmeghachi omume hypoglycemic nwere ike ime. Hydrochlorothiazide nwere ike imebi mmetụta nke ọgwụ antidiabetic. Ya mere, na mmalite nke ojiji nke ọgwụ ndị a n'otu oge, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose dị n'ọbara. Ekwesịrị iji Metformin jiri nlezianya mee ihe, nyere ihe ize ndụ nke lactic acidosis n'ihi ọdịda akụrụngwa nke ọrụ nwere ike n'ihi hydrochlorothiazide.

Ọgwụ antisteroidal anti-inflammatory ọgwụ (NSAIDs) na acetylsalicylic acid. A na-atụ anya mbelata na mmetụta antihypertensive nke Tritace Plus ®. Ọzọkwa, n'otu oge a ga-ejikọ ndị ACE inhibitors na NSAIDs nwere oke ihe ọghọm nke ọrụ ezumike nkuku na mmụba nke ọkwa potassium n'ime ọbara.

Anticoagulants nke ọgwụ . N'iji imekota ya na hydrochlorothiazide, enwere ike imebi ihe anticoagulant.

Corticosteroids, ACTH, amphotericin B, carbenoxolone, iji ọtụtụ ikikere, ọgwụ na-egbu egbu (yana iji ogologo oge) yana ọgwụ ndị ọzọ ejikọtara ọnụ ma ọ bụ ihe ndị na-arụ ọrụ na-ebelata oke potassium na plasma ọbara. Riskbawanye n'ihe egwu nke hypokalemia.

Nkwadebe Digitalis, ihe ndị na-arụ ọrụ nke nwere ike ịbawanye oge nke oge QT, ọgwụ antiarrhythmic. Na ọnụnọ nke elektrọnte elektrik (dịka ọmụmaatụ, hypokalemia, hypomagnesemia), mmetụta proarrhythmic nwere ike ịba ụba, mmetụta antiarrhythmic nwere ike ịkụda.

Ọgwụ nke mmetụta ya na-emetụta site na mgbanwe na ọkwa soda

A na-atụ aro ka ị na-agbakarị oge a na-atụle ọkwa sel potassium na nyocha ECG ma ọ bụrụ na a na-ewere hydrochlorothiazide na ọgwụ ndị ọ na-emetụta mgbanwe ndị dị na ọkwa potassium (dịka ọmụmaatụ, digitalis glycosides na ọgwụ antiarrhythmic) yana ọgwụ ndị na-esote na-akpata polymorphic pirouette ụdị tachycardia ( achricular tachycardia) (gụnyere ụfọdụ ọgwụ antiarrhythmic), ebe ọ bụ na hypokalemia bụ ihe na-eso akpata mmepe nke pirouette tachycardia:

ọgwụ klaasị ọgwụ antiarhythmic (quinidine, hydroquinidine, obedipyramide)
ọgwụ mgbochi III nke antiarrhythmic (amiodarone, sotalol, dofetilide, ibutilide)
ụfọdụ antipsychotics (wdg, thioridazine, chlorpromazine, levomepromazine, trifluoroorazine, ciamemazine, sulpiride, sultopride, amisulpiride, thiapride, pimozide, haloperidol, droperidol)
ọgwụ ndị ọzọ (dịka, bepridil, cisapride, difemanil, erythromycin maka nchịkwa intravenous, halofantrine, misolastine, pentamidine, terfenadine, vincamine maka nchịkwa intravenous).

Methyldopa. Achọpụtala ụfọdụ ọrịa anaemia na iji otu oge hydrochlorothiazide na methyldopa.

Cholestyramine ma ọ bụ ndị ọzọ ion mgbanwe resins nke a na-ewere ọnụ. Mwepu mmiri nke hydrochlorothiazide. Ekwesịrị ịụ ọgwụ sulfonamide dịkarịa ala 1:00 tupu ma ọ bụ awa 4-6 ka ị ofụ ọgwụ ndị a.

Curariform akwara dị jụụ. Nwere ike ịbawanye ma mụbaa oge izu ike nke akwara.

Ngwọta Calcium na ọgwụ na-abawanye ọkwa nke calcium na plasma ọbara. Site n'iji hydrochlorothiazide mee ihe n'otu oge, enwere ike ịtụ anya mmụba nke sọlfọ plasma, yabụ, ọ dị mkpa iji nlezianya nyochaa ọkwa nke calcium na plasma ọbara.

Carbamazepine. Enwere ihe ize ndụ nke hyponatremia n'ihi mmụba hydrochlorothiazide.

Ndị na-agbanwe iche na ayodiin nwere ayodiin. N'ihe banyere akpịrị ịkpọ nkụ nke mmiri ọgwụ metụtara, gụnyere hydrochlorothiazide, enwere ọghọm nke ịmalite nsogbu gbasara akụrụ, ọ kachasị mgbe ị na-a agentụ ọgwụ dị iche iche nke ndị na-egosi ayodiin nwere ayodiin.

Penicillin. Hydrochlorothiazide excretion na - apụta na tubules nke nephron, n'ihi nke a na - ebelata mkpịsị penicillin.

Quinine. Hydrochlorothiazide na-ebelata excretion quinine.

Vildagliptin. A hụrụ mmụba nke ọrịa angioneurotic edema na ndị ọrịa bụ ndị na-ewere ndị mgbochi ACE na vildagliptin n'otu oge.

Ndị na - egbochi MTOR (dịka Temsirolimus) . Enwere mmụba nke ọrịa angioedema na ndị ọrịa n'otu oge na-ewere ACE inhibitors na mTOR inhibitors (ebumnuche nke rapamycin na anụ).

Heparin. Enwere ike ịbawanye elu na ọnụọgụ potassium.

Mgbe ị na-etinye salseslates dị elu, hydrochlorothiazide nwere ike ịkwalite mmetụta ha na-egbu egbu na sistemụ akwara.

Site n'iji cyclosporine n'otu oge, hyperuricemia nwere ike ịbawanye elu ma ohere nke nsogbu dị ka gout nwere ike ịbawanye elu.

Mmanya na-egbu egbu Ramipril nwere ike iduga ụba vasodilation ma si otú a kwalite mmetụta mmanya.

Mmanya na-egbu egbu, barbiturates, ọgwụ ma ọ bụ ọgwụ mgbochi. Nwere ike ịkwalite hypotension orthostatic.

Nnu Enwere ike ịgwụ ike nke ọgwụ ọgwụ na-abawanye ma ọ bụrụ na -emekwu nnweta nnu na nri.

Beta blockers na diaxoside. Ojiji nke thiazide diuretics, gụnyere hydrochlorothiazide, na beta-blockers nwere ike ịbawanye n'ihe ize ndụ nke hyperglycemia.

Amantadine. Thiazides, tinyere hydrochlorothiazide, nwere ike ịbawanye ohere nke nsonaazụ nke amantadine.

Amonia Pressor (dịka adrenaline). Ọ ga - ekwe omume belata nsonaazụ nke amịrị pressor, mana obughi nke ga - ewepu ojiji ha.

Ọgwụ mgbochi-gout (probenecid, sulfinpyrazone na allopurinol). Enwere ike ịchọ ndozi nke ọgwụ uricosuric, ebe hydrochlorothiazide nwere ike ịbawanye ọkwa seric uric acid. O yikarịrị ka ọ ga-adị mkpa ịbawanye ọgwụ nke probenecid ma ọ bụ sulfinpyrazone. Site n'iji thiazides na-eme n'otu oge, mmụba nke ugboro ole a na-enwe nzaghachi allopurinol ga-ekwe omume.

Anticholinergics (dịka ọmụmaatụ, atropine, biperiden). N'ihi mmebi nke eriri afọ na mbelata ọnụọgụ nke mmiri na-apụ apụ na afọ, bioavailability nke ụdị diọsia thiazide na-abawanye.

Mmetụta ọgwụ ọjọọ na nsonaazụ nnwale

N'ihi mmetụta nke metabolism nke calcium, thiazides nwere ike imetụta nsonaazụ nke ntule nke ọrụ nke glands parathyroid (lee akụkụ "Akụkụ ojiji").

Nnukwu hyposensitization. N'ihi mgbochi nke ACE, ohere na ogo nke anaphylactic na mmeghachi omume anaphylactoid na venom ahụhụ na-abawanye. A kwenyere na a pụkwara ịhụ mmetụta a maka ihe nfụkasị ndị ọzọ.

Njirimara ngwa

Ndị otu ọrịa pụrụ iche

Ime Ọgwụ ekwesịghị ịnabata ndị ACE inhibitors ma ọ bụ ndị angagonensin II antagonist ekwesịghị ịmalite n’oge atụrụ ime. Ọ gwụla ma ọ bụrụ na ịga n'ihu na ọgwụgwọ na ACE inhibitor / angiotensin II antagonist antagonist dị mkpa, a na-ebufe ndị ọrịa na-eme atụmatụ ịtụrụ ime na ọgwụ antihypertensive ọzọ, nke a na-ahụta dị mma n'oge afọ ime.

Ihe ngbochi abuo nke renin-angiotensin- RAAS site na iji ọgwụ ndi nwere aliskiren

Ihe mgbochi abụọ nke renin-angiotensin site na iji ọgwụ Tritace Plus ® na aliskiren akwadoghị, ebe ọ bụ na enwere ohere ịba ụba, hyperkalemia na mgbanwe na ọrụ akụrụ.

Maka ndị ọrịa nwere ọrịa mellitus ma ọ bụ arụ ọrụ na-arụ ọrụ na-arụ ọrụ (GFR 60 ml / min), ejiri ọgwụ ọnụ jikọtara Tritace Plus ® na aliskiren (lee akụkụ "Contraindications").

Ọrịa dị oke egwu maka hypotension akwara

Ndị ọrịa nwere ọrụ nrụnye renin-angiotensin. N'ime ndị ọrịa nwere oke ọrụ nke renin-angiotensin-enwere ihe ọghọm nke mbelata ọbara mgbali elu na arụ ọrụ ezigharị na-akpata n'ihi mgbochi nke ACE. Nke a bụ eziokwu kacha bụrụ mgbe etinyere ACE inhibitor ma ọ bụ conceritant diuretic na nke izizi ma ọ bụ na-abawanye ọgwụ ahụ maka oge mbụ. Enwere ike ịtụ anya mmụba na ọrụ nke renin-angiotensin-chọrọ nlebara anya ọgwụ, gụnyere ilegide anya na ọbara mgbali elu, dịka ọmụmaatụ, na ndị ọrịa:

ya na obara mgbali elu,
na obi mgbakasị obi,
ya na ihe mgbochi hemodynamically di egwu nke uzo omimi ma obu obara site n’oghere aka ekpe (dika ima atu, stenosis nke aortic ma obu valvur mitali)
ya na akụrụngwa akwara gbasara akwara nọ na ọnụnọ akụrụ nke abụọ na-arụ ọrụ
nwere nnukwu mmiri mmiri ma ọ bụ enweghị elektrik (gụnyere ndị ọrịa a na-enweta diuretics),
na ọrịa nhụjuanya na / ma ọ bụ ascites,
onye na-awa ahu aru ma o bu n’azu ogwu nke neme ka obara idi ike.

Tupu ịmalite ọgwụgwọ, a na-atụkarị aro ka akpachapụ akpịrị, hypovolemia, ma ọ bụ electrolyte mmezi (agbanyeghị, na ndị ọrịa nwere nkụchi obi, a ga-eji nlezianya dozie usoro ndị ahụ n'ihe banyere ihe ize ndụ nke oke ibu).

N'ime ndị ọrịa nwere ọrụ imeju na-arụ ọrụ, ọ nwere ike ịkwalite mmeghachi omume maka ọgwụgwọ na Tritace Plus ® ma ọ bụ belata. Na mgbakwunye, na ndị ọrịa nwere ọrịa imeju nke imeju, nke edepụtara na edema na / ma ọ bụ ascites, enwere ike ịbawanye ọrụ nke usoro renin-angiotensin, ya mere, a ga-elebara anya pụrụ iche n'oge ọgwụgwọ ndị ọrịa a.

Ihe ogwugwo. Ọ bụrụ na ọ ga - ekwe omume, a ga-akwụsị ịhapụ ndị na - egbochi ACE, dịka ramipril, ụbọchị 1 tupu ịwa ahụ.

Ọrịa dị n'ihe banyere ọrịa obi ma ọ bụ ọrịa ụbụrụ ụbụrụ n'ihe nnwere onwe akwara ozi. N'ime usoro ọgwụgwọ mbụ, onye ọrịa chọrọ nlekọta ahụike nke ọma.

Isi hyperaldosteronism. Nchikota ramipril + hydrochlorothiazide abụghị ọgwụ ịhọrọ n'ịgwọ hyperaldosteronism. Agbanyeghị, ọ bụrụ na ejiri ramipril + hydrochlorothiazide na onye ọrịa nwere ọrịa hyperaldosteronism nke mbụ, ọ dị mkpa iji nlezianya nyochaa ọkwa nke potassium na plasma ọbara.

Ndị okenye na-arịa ọrịa. Lee mpaghara "Usoro Ọgwụ na Nchịkwa".

Ndị ọrịa nwere ọrịa imeju. N'ime ndị ọrịa nwere ọrịa imeju, echiche erughị ala sitere na ọgwụgwọ nke hydrochlorothiazide nwere ike iduga mmepe nke encephalopathy hepatic.

N'ihe banyere nsogbu imeju na ndị ọrịa na-arịa ọrịa imeju na-aga n'ihu, ekwesịrị iji thiazides jiri nlezianya mee ihe, ebe ọgwụ ndị a nwere ike ịkpata cholestasis intrahepatic, yana obere mgbanwe na mmiri mmiri nnu nwere ike ịkpasu mmepe nke hepatic coma. A na - egbochi hypothiazide n'ime ndị ọrịa nwere nnukwu ịba ọcha n'anya (lee mpaghara "Contraindications").

Nyochaa ọrụ akụrụ. Ekwesịrị inyocha ọrụ mmerụ ahụ tupu oge ọgwụgwọ yana iji dozie ya, ọkachasị izu ndị mbụ. Ndị ọrịa nwere nsogbu gbasara akụrụngwa (lee Nkebi "Usoro Ọgwụ na Nchịkwa") chọrọ nlezianya kachasị.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu. N'ime ndị ọrịa nwere ọrịa akụrụ, thiazides nwere ike ịmalite ọdịdị mberede nke uremia. N'ime ndị ọrịa nwere nsogbu akụrụngwa ezughi oke, mmetụta ngụkọta nke ihe ndị nọ n'ọrụ nwere ike ime.Ọ bụrụ na mmụba nke akụrụngwa akụrụ pụtara, dị ka egosipụtara site na mmụba nke nitrogen fọdụrụ, a ga-eji nlezianya tụọ mkpebi ikpe ịgbatị ọgwụgwọ. Ekwesịrị ịtụle iji kwụsị ị treatmentụ ọgwụ (lee mpaghara “Contraindications”).

Electrolyte ahaghioke. Dịka ọ dị na ndị ọrịa niile na-anata ọgwụgwọ n'ọba, ọ dị mkpa ịgụta ọkwa electrolytes n'ọbara plasma oge niile. Thiazides, gụnyere hydrochlorothiazide, nwere ike imebi mmebi nke mmiri-electrolyte (hypokalemia, hyponatremia na hypochloremic alkalosis).

Ọ bụ ezie na hypokalemia nwere ike ịmalite na ihe gbasara thiazide diuretics, ojiji nke ramipril na-eme n'otu oge nwere ike belata hypokalemia kpatara ọnya. Ihe ọghọm nke hypokalemia kacha elu na ndị ọrịa nwere ọrịa cirrhosis, ndị ọrịa nwere ọrịa diuresis, na ndị ọrịa na-ezuru electrolytes na-ezughị ezu, yana ndị ọrịa na-anata ọgwụgwọ n'otu oge corticosteroids na ACTH (lee Nkebi “Mmekọrịta na ọgwụ ndị ọzọ na ụdị ndị ọzọ mmekorita ”. N'ime izu izizi nke ọgwụgwọ, ekwesịrị ịbelata ọkwa nke plasma potassium mbụ. Ọ bụrụ na achọpụtara ọkwa potassium dị ala, mgbazi dị mkpa.

Nkpata nke hyponatremia nwere ike ime. Ntọala sodium dị ala nwere ike ibido bụrụ asymptomatic, yabụ ikpebi ego ole ọ dị dị ezigbo mkpa. N'ime ndị ọrịa agadi na ndị ọrịa cirrhosis, a ga-eme ụdị ule a ọtụtụ oge.

Egosipụta Thiazides ka ọ na - amụba urinary magnesium excretion, nke nwere ike ibute hypomagnesemia.

Hyperkalemia N'ime ụfọdụ ndị ọrịa natara ndị na - egbochi ACE, dị ka Tritace Plus ®, a hụrụ ọnọdụ nke hyperkalemia. Ndị otu nwere ọrịa hyperkalemia gụnyere ndị ọrịa nwere ọrịa akụrụ, ndị agadi (karịa afọ 70), ndị ọrịa enweghị ọrịa mellitus na-arịa ọrịa na-enweghị ọgwụgwọ ma ọ bụ ndị na-achịkwa nke ọma, ma ọ bụ ndị na-atsụ nnu, ihe ndị na-enye potassium, na ihe ndị ọzọ na-arụ ọrụ nke na-eme ka ọ̀tụ̀tụ̀ plasma na-eto ọbara, ma ọ bụ ndị ọrịa nwere ọnọdụ dịka akpịrị ịkpọ nkụ, mkpochapụ akwara ma ọ bụ acidicis metabolic. Ọ bụrụ n’otu oge a na-egosi ọgwụ ndị dị n’elu, a na-atụ aro ka ị na-elele ọkwa nke potassium n’ime plasma ọbara (lee Nkebi “iso ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ”).

Encephalopathy ịba ọcha n'anya. N'ime ndị ọrịa nwere ọrịa imeju, echiche amaghị ihe ọ bụla sitere na ọgwụgwọ nke ịba ọcha n'anya, gụnyere hydrochlorothiazide, nwere ike iduga mmepe nke encephalopathy hepatic. N'ihe banyere encephalopathy hepatic, ọgwụgwọ kwesịrị ịkwụsị ozugbo.

Hypercalcemia. Hydrochlorothiazide na-akpali mweghachi nke calcium na akụrụ, nke nwere ike ibute hypercalcemia. Nke a nwere ike gbagharia nsonaazụ nke ule emere iji mụọ ọrụ nke gril parathyroid.

Ọkpụkpụ Angioneurotic. N'ime ndị ọrịa na-anata ndị na - egbochi ACE, dị ka ramipril, a hụrụ angioedema (lee Akụkụ "Mmeghachi Omume"). N'ihe banyere angioedema, a ga-akwụsị ịgwọ Tritace Plus ® ozugbo ọgwụgwọ ọgwụgwọ ga-amalite. Onye ọrịa ahụ kwesịrị ịnọ n'okpuru nlekọta ahụike ma ọ dịkarịa ala awa iri na abụọ ruo iri abụọ na abụọ (iri abụọ na abụọ) ga - enwe ike wepụta ya mgbe mgbaàmà kpamkpam.

N'ime ndị ọrịa na-anata ihe mgbochi ACE, dịka Tritace Plus ®, enweela nsogbu nke angioedema nke eriri afọ (lee mpaghara "Mmeghachi omume"). Ndị ọrịa a mere mkpesa nke mgbu afọ (yana ma ọ bụ na ha enweghị ọgbụgbọ / ọgbụgbọ).

Mmeghachi omume anaphylactic n'oge hyposensitization. Site na iji ihe mgbochi ACE, ohere nke omume na ogo nke anaphylactic na mmeghachi omume anaphylactoid na venom ahụhụ na ihe nfụkasị ndị ọzọ na-abawanye.

Neutropenia / agranulocytosis. Ọrịa nke neutropenia / agranulocytosis adịkarịghị. A kọọkwa banyere mgbochi ụmị ọkpụkpụ. Iji mata ihe nwere ike ime leukopenia, a na-atụ aro ijikwa ọnụ ọgụgụ sel ọbara ọcha n'ime ọbara. Nleba anya ugboro ugboro na ọgwụgwọ maka ndị ọrịa nwere ọrụ mgbazinye nsogbu, na ndị ọrịa nwere njikọ collagenosis (dịka ọmụmaatụ, systemic lupus erythematosus or scleroderma) yana ndị na-a takingụ ọgwụ ndị ọzọ nwere ike ibute mgbanwe na foto ọbara (lee Nkebi “ nmekorita ya na ogwu ndi ozo na ndi ozo na nmekorita ya ”na mmeghachi omume ojoo”.

Ndịrịta iche nke agbụrụ. Ndị na - egbochi ACE nwere ike ịkpata ọrịa angioedema na ndị ọrịa agbụrụ Negroid karịa ndị nnọchite nke agbụrụ ndị ọzọ. Dị ka ndị ọzọ ACE inhibitors, mmetụta dị egwu nke ramipril nwere ike ghara ịkọwapụta na ndị ọrịa agbụrụ Negroid ma e jiri ya tụnyere ndị nnọchi nke agbụrụ ndị ọzọ. Nke a nwere ike ịbụ n'ihi eziokwu ahụ bụ na n'ọrịa ndị isi ojii na-arịa ọbara mgbali elu, a na-ahụkarị mgbali ọbara na arụ ọrụ adịghị ala.

Ndị na-eme egwuregwu Hydrochlorothiazide nwere ike inye nsonaazụ dị mma mgbe ị na-eme ule doping.

Ọ na-ahụkarị ọgwụ metabolism na endocrine. Ọgwụ nke Thiazide nwere ike belata nnabata glucose. N'ọnọdụ ụfọdụ, ndị ọrịa na-arịa ọrịa shuga nwere ike ịchọ ndozi nke insulin na ndị na-ahụ maka ọgwụ antidiedi. Mgbe ejiri thiazides gwọọ ya, ụdị ọrịa shuga na-arịa ọrịa nwere ike ịmalite ịghọ ihe pụtara ìhè.

Ọgwụ Thiazide diuretic nwere ike jikọta ya na cholesterol dị elu na triglycerides. N'ime ụfọdụ ndị ọrịa, ojiji nke thiazide diuretics nwere ike ịkpalite mmepe nke hyperuricemia ma ọ bụ nnukwu ọgụ nke gout.

Ughkwụ ụgbụ. Mgbe ị na-eji ndị na-egbochi ACE, a kọtụrụla ụkwara. Dịka iwu, ụkwara a adịghị amịpụta mkpụrụ, ọ na-agbatị ogologo ma na-apụ n'anya mgbe ịkwụsị ọgwụgwọ. Na nchọpụta ọdịiche dị na ụkwara, ị kwesịrị icheta ma ọ bụrụ na enwere ike ịrịa ụkwara nke ndị na-egbochi ACE.

Nnukwu myopia na nnukwu glaucoma nnukwu. Hydrochlorothiazide bụ nkwadebe sulfonamide. Ogwe Sulfanilamides na sulfonamide nwere ike ime ka omiosyncrasies na-eduga na myopia nwa oge na nnukwu mmechi mmechi glaucoma. Ihe mgbaàmà gụnyere nnukwu mmalite nke nhụjuanya anya na-ebelata ma ọ bụ ihe mgbu anya ma na-abụkarị n'ime awa ole na ole ruo ọtụtụ izu mgbe ịmalite ọgwụ.

Ọrịa glaucoma na-enweghị ọgwụgwọ nwere ike bute ọhụụ na-adịgide adịgide. Ọgwụ ọgwụgwọ kachasị maka ọnọdụ a bụ ịkwụsị ị takingụ ọgwụ ahụ ozugbo enwere ike. Enwere ike ịchọ nlekọta ahụike mberede ma ọ bụ nke ịwa ahụ ma ọ bụrụ na nrụgide intraocular na-enweghị nchịkwa. Ihe ndị dị ize ndụ maka ịmalite glaucoma nnukwu ọrịa nwere ike ịgụnye akụkọ ihe mere eme nke sulfonamide ma ọ bụ nke penisilini.

Dr. N'ime ndị ọrịa, n'agbanyeghị ọnụnọ nke akụkọ ihe mere eme dum

Mpempe mwepụta

Tritace Plus dị n'ụdị mbadamba.

Ere ọgwụ na-acha odo odo na agba, n'akụkụ ọ bụla enwere ihe ndenye nkewa. N'elu ya bụ stampụ 41 / AV. Anabataghị inwetara nke ọ bụla gbara ọchịchịrị.

Ere ọgwụ gbara agba gbara agba na agba, n'akụkụ ya abụọ enwere ihe nkerisi. N'elu ya bụ stampụ 42 / AY. Anabataghị inwetara nke ọ bụla gbara ọchịchịrị.

Mbadamba ụrọ fọrọ nke nta ka ọ bụrụ ọcha, nwere agba-acha nwere nsogbu nkewa, ọdịdị ya. N'akụkụ abụọ a, e nwere akara ụlọ ọrụ na stampụ HNW.

Erere ọgwụ ike na-acha odo odo. E nwere oke nkerisi na akụkụ abụọ. Stampụ 39 / AV. Anabataghị ịhapụ ebe gbara ọchịchịrị.

Omume ọgwụ

Ejikọtara ọnụ ọgwụ antihypertensive, nke mejupụtara ihe arụ ọrụ abụọ na-arụ ọrụ.

Ihe mejuputara ugbua bu ACE enzyme inhibitor. Ofkpụrụ nke mmetụta na-egbochi igbochi ntụgharị nke otu ụdị angiotensin (M) nye onye ozo (II).

N'okwu a, enweghi mmụba nke obi site na usoro nkwụghachi ụgwọ, a naghị ebelata mmepụta aldosterone, ọkwa nke nrụgide na capillaị nke sistem oriọna anaghị agbanwe, anaghị abawanye ọbara ọgbụgba, mmụba na glomeruli nke sistem ngbanwe adịghị agbanwe agbanwe, nguzogide n’ime arịa nke sistem n’akpịrị na-agbanwekwa na ọkwa mbụ.

Ọmụmụ ihe omimi egosila na ọgwụgwọ ogologo oge na-eduga n'ịdị ogo ọbara myocardial n’ebe ndị ọrịa na-ata ahụhụ ọbara mgbali elu. Na ischemic myocardium Ramipril na - akwalite mgbasa ọbara, na - ebelata ugboro ugboro myocardial reperfusion yana ihe nwere ike ịmalite arrhythmias.

A na - enweta mmetụta Cardioprotective (obi +) n'ihi nsonaazụ nke usoro njikọ ahụ prostaglandinsọ bụkwa n'ihi nhiwe nke nitric oxide na mkpụrụ ndụ endotheliocyte. Ngwakọta ọrụ nọ n'ọrụ nwere ike belata nchịkọta platelet.

Hydrochlorothiazide

Ihe mejuputara ugbua bu thiazide diureticma nwee ike ịgbanwe reabsorption nke potassium, chlorine, sodium, magnesium ion. Ihe na-arụ ọrụ na-egbu oge uric acid na anụ ahụ, na-eji nwayọ nwayọ nwayọ n ’usoro nke calcium ion, na-agbanwe ntighachi mmiri na nephrons (ngalaba distal).

A na - enweta mmetụta antihypertensive site na ịkwalite mmetụta na - akpata nkụda mmụọ megide ganglia, na - ebelata ịdị njọ nke mmetụta ndị nrụgide. norepinephrine, adrenaline na amịrị vasoconstrictor ndị ọzọ, n'ihi mbelata BCC. N'okpuru nkịtị ọbara mgbali Anaghị egosipụta mmetụta hypotensive.

A na-egosipụta Ramipril na hydrochlorothiazide site na mgbakwunye. Hydrochlorothiazide na-ekpudo potassium site n'ahụ ahụ, Ramipril na-ewepụ mmetụta a, na-egbochi ọnwụ nke K +.

Pharmacodynamics na pharmacokinetics

A na-edekọ mmetụta antihypertensive nke Ramipril 90 nkeji mgbe ọ takingụsịrị ọgwụ ahụ, ana-ahụpụta nsonaazụ kachasị mgbe awa 5-9 gachara. Mmetụta ahụ dịgidere ụbọchị dum. Mgbe emechara ọgwụgwọ, usoro “mwepu” adịghị etolite. Mmetụta diuretic hydrochlorothiazide na-apụta mgbe awa 1-2 gachara.

A na-ahụta nsonaazụ kachasị mgbe elekere anọ gasịrị ma nwee ike ịdịru elekere 12. A na-ahụ mmetụta antihypertensive mgbe ụbọchị 3-4 gasịrị, otu ọ dị, ọ ga-ekwe omume nweta arụmọrụ ọgwụgwọ kachasị mma naanị mgbe ọ gachara izu 3-4.

Nsonaazụ

Usoro obi:

Ọkpụkpụ mkpụrụ ndụ:

mbelata libido
proteinuria
mbelata mmamịrị,
ụba ogo nke ihe mgbaàmà nke ọdịda akwara.

Usoro ụjọ:

ụjọ ụjọ
mgbanwe ischemic na ụbụrụ,
anya ntughari,
adịghị ike
paresthesia
ịmụba iro ụra
nchegbu
nchegbu
nsogbu ịrahụ ụra, ehighị ụra nke ọma,
obi erughi ala,
ịkụda mmụọ
ndaba,
nkụda mmụọ
ukwu aka.

Akụkụ akụrụngwa:

mgbanwe n'ime ntụnye ụtọ,
nkwarụ anya,
ọgba aghara vestibular
tinnitus.

Ọna nri:

Usoro okuku ume:

Azịza Allergic:

mmụọ ire, egbugbere ọnụ, larynx ma ọ bụ n'ihu isi,
akpụkpọ anụ ahụ,
angioedema nke nsọtụ ya,
serositis
pemphigus
Ọrịa Lyell
ndise
vasculitis
dermatitis na-efe efe,
akpụkpọ anụ?
urticaria
myositis
ọrịa ogbu na nkwonkwo
onycholysis,
eosinophilia.

Akụkụ Hematopoietic:

pancytopenia
mbelata hemoglobin,
agranulocytosis,
thrombocytopenia
hemolytic anaemia,
erythropenia.

Mmetụta enwere ike na nwa ebu n’afọ:

ọkpụkpụ nke okpokoro isi,
hyperkalemia
nchọpụta nke ọgwụ antiinuclear,
hyponatremia,
nkwekọrịta ukwu
hyperazotemia,
mgbanwe na arụ ọrụ nke sisitemu sistem,
dobe n'ọbara
oligohydramnios
hypoplasia nke ọkpụkpụ nke okpokoro isi.

Mmeghachi omume ụlọ nyocha:

nchọpụta nke ọgwụ antiinuclear,
hyperkalemia
hyperazotemia,
hypercreatininemia,
hyperbilirubinemia,
mụbara ALT, AST, bilirubin.

Mmeghachi omume ndị ọzọ:

Omume jọrọ njọ nke hydrochlorothiazide:

arrhythmia,
mgbakasị ahụ
ndaba,
ike nke psyche na onodu,
hypochloremic alkalosis,
afọ ọsịsa
cholecystitis
tachycardia,
anaemia (aplastic, hemolytic),
orthostatic hypotension,
mgbu mgbu
sialadenitis
pancreatitis
anorexia
hyperuricemia
hyperglycemia
ihe ojoo nke gout,
na-arịa ọrịa vasculitis,
akpụkpọ anụ ahụ,
oyi baa
ụkwara ume ọkụ nke sitere na mkpụrụ ndụ abụghị.

Ntụziaka na Tritac Plus (Usoro na usoro onunu ogwu)

Sing na-eme atụmatụ iburu n'uche njirimara mmadụ. Oge nnabata a tụrụ aro bụ elekere ụtụtụ. Ihe kachasị akwadoro kwa ụbọchị bụ ị were mbadamba 2 na ọgwụ 5 + 25 ma ọ bụ 4 na mbadamba 2.5 + 12.5, nke kwekọrọ na 50 mg nke hydrochlorothiazide na 10 mg nke Ramipril.

Mgbe ha na-amapụ ọgwụ, ha na-anwa were ya ngwa ngwa o kwere mee. Anaghị anabata onwe gị ugboro ole a doseụsịrị ya. Mbadamba ga-eji mmiri sachaa mbadamba, anabataghị ịta ata. Nri anaghị emetụta ogo nke ọgwụgwọ ọgwụgwọ nke Tritace Plus.

Jiri n’oge ime na n’oge a na-enye nwa ara

Ekwesighi iji Tritace ® Plus n'oge ime. Yabụ, tupu ị theụ ọgwụ ọjọọ n'ime ụmụ afọ ọmụmụ, a ga-agụpụ afọ ime, yana n'oge ọgwụgwọ ha kwesịrị iji ụzọ ịtụkwasị obi nke igbochi afọ ime. N'ihe banyere ime n'oge ị duringụ ọgwụ, ị kwesịrị ịkwụsị ị itụ ya ngwa ngwa o kwere mee ma nyefee onye ọrịa ahụ ka ọ takingụọ ọgwụ ndị ọzọ na - egbochi ọgwụ, nke ihe ize ndụ maka nwatakịrị ahụ ga-akacha.

N'ihi ihe egwu nke ramipril na hydrochlorothiazide na nwa ebu n’afọ, a na-atụ aro ka ndị ụmụ nwanyị na-enweghị ike ibugharị na ọgwụgwọ ọzọ maka ọbara mgbali elu (na-enweghị ndị na-egbochi ACE na diuretics) ka ha zere ịtụrụ ime.

Amabeghị ma mmetụta Tritace ® Plus n'ime oge ọnwa atọ nwere ike imetụta mmepe nke nwa ebu n’afọ. Ojiji nke ACE n’ime mgbochi nke abụọ na nke atọ nke afọ ime jikọtara ya na nsogbu ndị nwere ike ịbe nwa ebu n’afọ na nwa amụrụ ọhụrụ, gụnyere mgbada ọbara mgbali, hypoplasia ọkpụkpụ cranial, anuria, ndọghachi azụ ma ọ bụ ọdịda akụrụngwa akwara, na ọnwụ.

A kọkwara mmepe nke oligohydramnios, o doro anya na ọ bụ n'ihi nbibi nke akụrụ nwa ebu n’afọ, oligohydramnios n’ọnọdụ ndị a sokwa ya na nkwekọrịta nke nsọtụ nwa ebu n’afọ, mmebi nke akwara mkpụrụ ndụ, ịmụba amụba na intrauterine na-enweghị mmechi nke botallic ya (ọ bụ na ọ bụghị ya) mmetụta ndị a bụ mmetụta nke onye na - egbochi ACE.

A na-atụ aro iji nlezianya nyochaa ụmụ amụrụ ọhụrụ ndị ekpughere intrauterine kpughere ndị na-egbochi ACE iji chọpụta mbelata ọbara mgbali, oliguria na hyperkalemia. Na oliguria, ọ dị mkpa iji nọgide na-enwe ọbara mgbali na mmanụ na-esi ísì ụtọ site na iwebata mmiri kwesịrị ekwesị na ọgwụ vasoconstrictor. Sdị ụmụ amụrụ ọhụrụ a nwere ihe egwu ibute ọrịa oliguria na nsogbu akwara ozi, n'ihi mbelata ọbara na akụrụngwa yana usoro ọbara n'ihi mbelata ọbara mgbali nke ndị na - egbochi ACE. Echere na site na iji hydrochlorothiazide n'oge ọnwa nke abụọ nke afọ ime, mmepe nke thrombocytopenia na ụmụ amụrụ ọhụrụ ga-ekwe omume.

Oge ara

Ebe ọ bụ na ramipril na hydrochlorothiazide dị na mmiri ara, ọ bụrụ na ọ dị mkpa iji ọgwụ Tritace gbakwunye n'oge a na-enye nwa ara, a ga-akwụsị inye ya ara.

Usoro onunu ogwu na nhazi

Ofzọ nke ngwa

E kwesiri iji mmiri zuru oke were were iko mmiri (1/2 iko). Mbadamba nkume enweghị ike egwepịa ma rie ata. Nri adighi enwe mmetụta di egwu na bioavailability nke ogwu, ya mere enwere ike iwere ya tupu, mgbe nri ma ọ bụ mgbe nri ahụ gasịrị. A na-atụkarị aro ka a doseụọ kwa ụbọchị otu oge n'otu oge n'ụbọchị, ọkachasị n'ụtụtụ.

Usoro ịchọrọ na Sharp Dosing tụrụ aro

A na-ahọrọ doses nke ọgwụ ahụ n'otu n'otu. Nhọrọ nke doses bụ nke dọkịta na-eme dabere ogo ọbara mgbali elu na ọnụnọ nke ihe ndị metụtara ihe egwu, yana nnabata ọgwụ a.

A na - ahọpụta nrịba nke Tritace Plus site na ntinye ọnụ (mmụba nwayọ ma ọ bụ, ọ bụrụ na ọ dị mkpa, Mbelata) nke usoro ramipril na hydrochlorothiazide n'otu oge.

Mgbe ahọpụtachara onye ọrịa ahụ ọgwụ ramipril na hydrochlorothiazide, maka ịdị mma nke ndị ọrịa, enwere ike dochie anya ị intụ ọgwụ ahụ site na ị theụ ọgwụ Tritace gbakwunyere usoro kwesịrị ekwesị, na-ejide n'aka na a na-ewere ọgwụ ndị ahụ nke ramipril na hydrochlorothiazide n'otu mbadamba.

Ọgwụ na-adịkarị: 2.5 mg ramipril na 12.5 mg hydrochlorothiazide otu ugboro kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, dose ahụ nwere ike ịbawanye site na etiti oge izu abụọ.
N'ime ndị ọrịa na-enweghị ike nweta mbelata ọbara mgbali dị mkpa na ramipril monotherapy na 10 mg, ma ọ bụ na ndị ọrịa nwere mbelata ọbara mgbali dị mkpa nke a na-enweta na ramipril na 10 mg na hydrochlorothiazide na usoro nke 12.5 mg -25 mg weere dị ka nkwadebe dị iche, ọ ga-ekwe omume iji ọgwụ Tritace ® gbakwunye 12.5 mg + 10 mg na 25 mg + 10 mg.

N'ọtụtụ oge, ọbara mgbali ga-agbadata nke ọma mgbe ị na-ewere Tritace ® Plus na usoro onunu ogwu site na 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide na 5 mg nke ramipril na 25 mg nke hydrochlorothiazide. Usoro akwadoro usoro onunu ogwu na usoro onunu ogwu di iche-iche

Ọgwụgwọ ndị ọrịa na-anata ọrịa ịba
Ọrịa ndị agabatabeghị ọgwụgwọ nke gara aga tupu ha a theụ ọgwụ Tritace gbakwunyere, ọ bụrụ na ọ ga - ekwe omume ụbọchị 2-3 ma ọ bụ karịa (ọ dabere na oge mmeju nke ọnya ahụ), a ga-akagbu ma ọ bụ, opekata mpe, belata dose ahụ.
Ọ bụrụ na ọ gaghị ekwe omume ịkwụsị ị diụ ọgwụ, a na-atụ aro ịmalite ọgwụgwọ na obere usoro ramipril (1.25 mg kwa ụbọchị) na njikọ a, na-a drugsụ ọgwụ dị iche iche nke ramipril na hydrochlorothiazide. A na-atụ aro na n'ọdịniihu, aga-ebufe inyefe Tritace ® gbakwunyere n'ụzọ nke na nha mbụ kwa ụbọchị agaghị agafe 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide. Ọgwụgwọ ndị ọrịa nwere ọrụ ezughi oke ọrụ
Mgbe mwepụ nke creatinine sitere na 30 ruo 60 ml / min kwa 1.73 m2 nke mpaghara ahụ dị elu, ọgwụgwọ na-amalite site na ramipril monotherapy kwa ụbọchị nke 1.25 mg.
Mgbe mmụba nke nwayọ nke ramipril, ọgwụgwọ na ọgwụ ngwakọta na-amalite site na iji ọgwụ mgara nke 2,5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide. Oke kacha akwadoro kwa ụbọchị maka ndị ọrịa nwere akwara bụ 5 mg ramipril na 25 mg hydrochlorothiazide. Ndị ọrịa dị otú a ekwesịghị ịnara mbadamba Tritace ® gbakwunyere 12.5 mg + 10 mg na 25 mg + 10 mg.

Ọgwụgwọ ndị ọrịa nwere obere (5-6 isi na Child-Pyo ọnụ ọgụgụ) ma ọ bụ agafeghị oke (isi ihe 7-9 maka nha Child-Pyo) arụ ọrụ imeju.
Ọgwụgwọ na Tritace ® gbakwunyere kwesịrị ịmalite n’okpuru nlekọta ahụike yana oke ramipril kwa ụbọchị kwesịrị ịbụ 2.5 mg.
N'ime ndị ọrịa dị otú ahụ, enweghị ike iji mbadamba Tritace ®, gbakwunye 25 mg + 5 mg, 12.5 + 10 mg 25 mg + 10 mg.

Ọgwụgwọ ndị ọrịa agadi
Ọgwụ kwesịrị ịmalite nke obere doses, na mmụba nke doses kwesịrị ịdị nwayọọ nwayọọ (na obere mmụba nke doses) n'ihi oke ohere nke nsonaazụ, karịsịa na ndị ọrịa na-esighi ike.

Dose kwuo

Mgbe ịwụsịrị usoro ọzọ, ekwesịrị ị doseụ ọgwụ ahụ echere ozugbo enwere ike. Agbanyeghị, ọ bụrụ na achọtara ihe a dị nso na oge ị ofụ ọgwụ na-esote, ọ dị mkpa ka ịhapụ ọgwụ ahụ achụrụ ma laghachi na usoro a na-emebu, na-ezere ịgbagha mkpụrụ ọgwụ ahụ na obere oge.

Mmetụta akụkụ

Ihe ndị a bụ mmetụta ndị na - achọghị mma nwere ike ime na iji Tritace ® gbakwunyere, ihe ndị na - arụ ọrụ ya (ramipril na hydrochlorothiazide), ndị ọzọ na - egbochi ACE, ma ọ bụ ihe ndị ọzọ dị ka hydrochlorothiazide, nke enyere dị ka usoro ndị a na - esote ugboro ole ha mere:
ugboro ugboro (≥ 10%), mgbe (≥ 1% - Ọrịa obi
Ugboro ugboro: ischemia myocardial, tinyere mmepe nke angina pectoris, tachycardia, cardiac arrhythmias, palpitations, akụkụ isi.
Amaghi ama: infarction myocardial.

Ọrịa sitere na ọbara na sistem lymphatic
Ugboro ugboro: mbelata nke ọnụ ọgụgụ leukocytes n'ọbara mgbatị, mbelata ọnụọgụ ọbara ọbara na mgbagwọ ọbara, mbelata hemoglobin, hemolytic anaemia, mbelata ọnụ ọgụgụ platelet n'ọbara.
Ugboro amaghi: mmebi nke ụmị ọkpụkpụ, gụnyere agranulocytosis (mbelata nke ukwuu ma ọ bụ mfu nke granulocytes site na oke ala), pancytopenia, eosinophilia, hemoconcentration n'ihi mbelata nke ihe ndị dị n’ime ahụ, gụnyere ọbara n’onwe.

Ọrịa nke sistem
Ọtụtụ mgbe: isi ọwụwa, ịmụ anya isi (mmetụta nke “ịdị nfe”) na isi).
Ugboro ugboro: vertigo, paresthesia, shoor, ahaghị n ’ọhụụ, anụ ahụ na - ere ọkụ, dysgeusia (nke megidere uto), agegezia (ida uto).
Amaghi ama: ischemia ụbụrụ, gụnyere ọrịa ọgbụgbọ na ụbụrụ nke ụbụrụ na - akpata nsogbu, mmeghachi omume psychomotor, parosmia (isi na - esite na ya, tinyere isi nke isi ọ bụla na - enweghị isi).

Mmebi nke akụkụ nke ọhụụ
Ugboro ugboro: ọgba aghara a na-ahụ anya, gụnyere ihie nke ihe a na-ahụ anya, conjunctivitis.
Amaghi ama: xantopsia, mbelata nke mmepụta nke mmiri mmiri (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Mmetụta ntị na nkwarụ labyrinthine
Ugboro ugboro: na-akụ ntị.
Ugboro amaghi: okfu nụ.

Ọkpụkpụ nke sistem, obi na akụkụ akụkụ ahụ
Ọtụtụ mgbe: ụkwara ("akọrọ") ụkwara, ọnya afọ.
Ugboro ugboro: sinusitis, mkpụmkpụ ume, imi mkpọchi.
Amaghi ama: bronchospasm, tinyere ihe mgbaàmà nke ụkwara ume ọkụ bronchial, alveolitis nfụkasị (pneumonitis), edema na - abụghị cardiogenic pulmonary edema (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Ọgba aghara digestive
Ugboro ugboro: mmeghachi omume mbufụt nke akpụkpọ ahụ mucous nke eriri afọ, mgbari nri, ahụ erughị ala nke afọ, dyspepsia, gastritis, ọgbụgbọ, afọ ntachi, gingivitis (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).
Ọ dịkarịghị: vomiting, aphthous stomatitis, glossitis, afọ ọsịsa, mgbu epigastric, mucosa a na-ede ede.
Ugboro amaghi: pancreatitis (n'ọnọdụ pụrụ iche, mgbe ị na-ewere ndị na-egbochi ACE, a hụrụ ọgwụ pancreatitis na-egbu egbu), ịba ụba nke enzymes pancreatic n'ime ọbara, ọrịa angioedema nke obere eriri afọ, sialadenitis (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Mmebi nke akụrụ na eriri afọ
Ugboro ugboro: arụmọrụ gbasara akụrụ, gụnyere oke akụrụ gbasara akwara, mmụba nke mmamịrị ahụ, mmụba nke mkpokọta urea n'ọbara, mmụba na nsụpụta nke creatinine n'ime ọbara (ọbụla nwude ntakịrị na ntinye uche nke creatinine na ụkwara akwara akwara dị obere nwere ike igosi ọrụ ezigoro arụmọrụ).
Ugboro amaghi: ụba proteinuria, interstitial nephritis (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Ọkpụkpụ nke anụahụ na anụ ahụ dị n'okpuru ala
Ugboro ugboro: ọrịa angioedema: n'ọnọdụ ndị pụrụ iche, ihe mgbochi nke ụzọ ikuku n'ihi angioedema nwere ike ibute ọnwụ, ọrịa psoriasis-dị ka dermatitis, ịba ụba aja aja, ọnya anụ ahụ, ọkachasị, akwara paakilar akpukpo aru, ọnya isi, isi nkwọcha.
Amaghi ama: tocrolysis na-egbu egbu, Stevens-Johnson syndrome, erythema multiforme, pemphigus, na-akawanye njọ nke psoriasis, exfoliative dermatitis, mmeghachi omume fotoisiti, onycholysis, pemphigoid ma ọ bụ lichenoid exanthema ma ọ bụ enanthema, urticaria, systemic lupus erythematosus antiisseisation.

Ọkpụkpụ akwara na uru ahụ
Ugboro ugboro: myalgia.
Ugboro amaghi: ọrịa ogbu na nkwonkwo, nkwonkwo akwara spastic, adịghị ike akwara, isi ike, tetany (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Ọrịa site na usoro endocrine
Ugboro amaghi: ọrịa nke ezughị oke nke homonụ antidiuretic (SNA ADH).

Ọrịa metabolism na nri nri
Ọtụtụ mgbe: decompensation nke ọrịa shuga mellitus, ibelata nnabata glucose, ịba ụba nke glucose n'ọbara, mụbaa ịta ahụhụ uric acid n'ime ọbara, mụbaa mgbaàmà nke gout, ịba ụba nke cholesterol na triglycerides n'ime ọbara (n'ihi ọnụnọ nke hydrochlorothiazide na ihe mejupụtara).
Ugboro ugboro: anorexia, agụụ belatara, belata potassium n'ime ọbara, akpịrị ịkpọ nkụ (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).
Oke: mụbara potassium n'ime ọbara (n'ihi ọnụnọ ramipril na nkwadebe).
Ugboro amaghi: mbelata nke sodium ọbara, glucosuria, alkalal metabolic, hypochloremia, hypomagnesemia, hypercalcemia, akpịrị ịkpọ nkụ (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).

Ọrịa vaskụla
Ugboro ugboro: mbelata nke ukwuu na ọbara mgbali elu, hyperension orthostatic (ọ na - egbochi orthostatic usoro nke ụda vaskụla), ịda mba, ịwụfu ọbara ọbara n'ihu.
Ugboro amaghi: thrombosis nwere nnukwu mfu nke mmiri, vaskụla stenosis, ihe omume ma ọ bụ nbawanye ike nke mgbasa ọbara na nzụlite ọnya ọnya afọ, Raynaud's syndrome, vasculitis.

Ọrịa na nkwarụ izugbe na saịtị ịgba ahụ
Ọtụtụ mgbe: ike ọgwụgwụ, asthenia.
Ugboro ugboro: mgbu obi, ahụ ọkụ.

Ọrịa sistem
Amaghi ama: mmeghachi omume anaphylactic ma ọ bụ anaphylactoid na ramipril (yana mgbochi ACE, mmụba nke anaphylactic siri ike ma ọ bụ mmeghachi omume anaphylactoid na venom ụmụ ahụhụ ga-ekwe omume) ma ọ bụ mmeghachi omume anaphylactic na hydrochlorothiazide, mmụba nke titin antinuclear antibody titer.

Nmebi nke imeju na ọnya biliary
Ugboro ugboro: cholestatic ma ọ bụ cytolytic ịba ọcha n'anya (n'ọnọdụ ndị pụrụ iche na nsonaazụ na-egbu egbu), mmụba nke ọrụ enzymes “imeju” na / ma ọ bụ mmụba nke mkpokọta bilirubin n'ọbara, cholecystitis na-enweghị atụ (n'ihi ọnụnọ hydrochlorothiazide na nkwadebe).
Ugboro amaghi: nnukwu imeju okpu, ọrịa cholestatic jaundice, ọnya hepatocellular.

Mmebi nke akụkụ anụ ahụ na mammary gland
Ugboro ugboro: dysfunction adịgboroja.
Ugboro amaghi: mbelata libido, gynecomastia.

Ọrịa uche
Ugboro ugboro: ọnọdụ obi erughị ala, enweghị mmasị, nchekasị, ahụ́ ịma jijiji, nsogbu ịrahụ ụra (gụnyere ịrahụ ụra).
Amaghi ama: mgbagwoju anya, nchekasị, nlebara anya na-ebelata (ịtalata ịta).

Mmeghachi omume ọjọọ

Ihe nchekwa nchekwa Ramipril gụnyere ụkwara akwara na-ekweghị akwụsị akwụsị na mmeghachi omume n'ihi ọbara ọgbụgba. Mmeghachi omume ọjọọ dị na ọnya gụnyere ọnya afọ, myocardial infarction, angioedema, hyperkalemia, ọrụ akwara nwere nsogbu ma ọ bụ ọrụ ịba ọcha ahụ, ọrịa akwara na-eme ka akpụkpọ ahụ na -akpata ya, yana neutropenia / agranulocytosis.

Mmeghachi omume kachasị na-akọkarị n'oge ọgwụgwọ na amlodipine bụ ụra, ọgbụgbọ, isi ọwụwa, tachycardia, hyperemia, ọnya afọ, ọgbụgbọ, ọzịza na nkwonkwo ụkwụ, ọzịza, na ịba ụba ike.

A na-ekewa ọnọdụ mmeghachi omume dị ka ndị a: ọtụtụ mgbe (≥ 1/10), ọtụtụ mgbe (≥ 1/100 ruo