Otu esi eji Lorista N maka ọrịa shuga

Lorista ® N - ọgwụ ejikọtara ọnụ, nwere mmetụta hypotensive.

Losartan. Nhọrọ antiotensin II na-anabata antagonist (ụdị AT 1) maka nchịkwa ọnụ, ọdịdị na-abụghị protein. Na vivo na in vitro losartan na ya na ihe ndi mmadu na - eme ka ihe ndi ozo na - eme ka ihe ndi ozo di ndu (EXP-3174) na - egbochi ihe anakpo physiologically di ukwu nke angiotensin II na ndi natara AT 1.

Losartan na-akpata esemokwu na-anabata ndị na-anabata ndị ọrụ AT 2 site na ịba ụba ọkwa nke angiotensin II.

Losartan adịghị egbochi ọrụ kininase nke abụọ, enzyme nke na-etinye aka na metabolism nke bradykinin.

Ọ na - ebelata OPSS, nrụgide dị na okirikiri nke “ọbara” na - erugharị n’ọbara, na - ebelata ibu mgbe ebusara ya, nwere mmetụta ọria.

Ọ na-egbochi mmepe nke hypertrophy myocardial, na-eme ka nnabata mmega ahụ nwee ndị ọrịa nwere nkụda mmụọ obi na-adịghị ala ala. Iwere losartan otu ugboro kwa ụbọchị na-eduga na mbelata dị ukwuu na SBP na DBP. Losartan na-ejikwa nrụgide ahụ na-achịkwa ụbọchị ahụ dum, ebe mmetụta antihypertensive kwekọrọ na ụda mmiri nke circadian. Mbelata ọbara mgbali elu na njedebe nke ọgwụ ahụ bụ ihe dịka 70-80% nke nsonaazụ ahụ dị elu nke ọgwụ ahụ, 5-6 awa mgbe nchịkwa gasịrị. Achọpụtaghị n ’ịba n’ ọrịa ahụ, losartan enweghị mmetụta ọmalịcha n’egwuregwu obi.

Losartan dị irè na ụmụ nwoke na ụmụ nwanyị, yana ndị agadi (karịa afọ 65) na ndị ọrịa na-eto eto (ndị dị n'okpuru afọ 65).

Hydrochlorothiazide. A ọrịa thiazide diuretic, nke mmetụta diuretic ya nwere bụ ihe jikọtara ya na mmebi nke reabsorption nke sodium, chlorine, potassium, magnesium, ion mmiri na nephron distal, na-egbu oge mkpụsị sọlfọ ion, uric acid. Ọ nwere antihypertensive Njirimara. Fọrọ nke nta ọ nweghị mmetụta ọ bụla na ọbara mgbali nkịtị.

Mmetụta ọgbụgba ahụ na-apụta mgbe awa 1-2 gachara, rutekarị mgbe ọ gachara 4, wee bido awa 6-12. Mmetụta antihypertensive na-apụta mgbe ụbọchị 3-4 gachara, mana ọ nwere ike were izu 3-4 iji rụpụta ezigbo ọgwụgwọ ọgwụgwọ.

Mlọ ọgwụ

Aclọ ọgwụ ọgwụ nke losartan na hydrochlorothiazide mgbe ewere ya n'otu oge adịghị iche na nke ahụ mgbe ejiri ya iche.

Losartan. Ọ na-etinye obi gị dum na ngọngọ nri. Ọ na - eme metabolism dị mkpa n'oge "ụzọ mbụ" site na imeju, na - akpụ metabolite na - arụ ọrụ (EXP-3174) yana carbonxylic acid na metabolites ndị ọzọ na - adịghị arụ ọrụ. Bioavailability dị ihe dịka 33%. Withakingụ ọgwụ ahụ nwere nri adịghị enwe mmetụta ọfụma na ụlọ ọgwụ n'ọbara ya. T max - 1 awa mgbe nchịkwa ọnụ, yana metabolite ya na-arụ ọrụ (EXP-3174) - awa 3-4.

Ihe karịrị 99% nke losartan na EXP-3174 na-ejikọ protein protein, ọkachasị na albumin. Olu nke nkesa losartan bu lita 34. Ọ banyere n'ụzọ ọjọọ nke ukwuu site na BBB.

Losartan bụ metabolized site na nguzobe nke metabolites na-arụ ọrụ (EXP-3174) (14%) na arụ ọrụ, gụnyere 2 isi metabolites guzobere site na hydroxylation nke otu butyl nke yinye, yana metabolite dị obere - N-2-tetrazole glucuronide.

Mkpochapu plasma nke losartan na metabolite na-arụ ọrụ bụ ihe dịka 10 ml / s (600 ml / min) na 0.83 ml / s (50 ml / min), n'otu n'otu. Nwepu nke rensa na losartan na metabolite ya na-arụ ọrụ bụ ihe dịka 1.23 ml / s (74 ml / min) na 0.43 ml / s (26 ml / min). T 1/2 nke losartan na metabolite na-arụ ọrụ bụ awa 2 na awa 6-9, n'otu n'otu. Emere ya karie ka bile - 58%, akụrụ - 35%.

Hydrochlorothiazide. Mgbe nchịkwa ọnụ gachara, ntinye nke hydrochlorothiazide bụ 60-80%. A na - enweta C max hydrochlorothiazide n'ime ọbara 1-5 awa mgbe abata.

Ihe jikọtara na protein plasma nke hydrochlorothiazide bụ 64%.

Hydrochlorothiazide adịghị metabolized ma ọ na-apịpụta ngwa ngwa site na akụrụ. T 1/2 bụ 5-15 awa.

Ọnọdụ pụrụ iche

• Taabụ 1 losartan potassium 100 mg hydrochlorothiazide 25 mg Ndị ọkachamara: pregelatinized stachi - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Ngwakọta nke akpụkpọ ahụ ihe nkiri: hypromellose - 10 mg, macrogol 4000 - 1 mg, quinoline odo (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potassium 100 mg hydrochlorothiazide 12.5 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc. losartan potassium 100 mg hydrochlorothiazide 25 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Ihe ndị dị mkpa: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate Shell: hypromellose, macrogol 4000, quinoline acha odo odo (E104), titanium dioxide (E171), tal. losartan potassium 50 mg hydrochlorothiazide 12.5 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc.

Lorista N contraindications

• Hypersensitivity na losartan, na ọgwụ ndị a na - enweta site na sulfonamides na akụkụ ndị ọzọ nke ọgwụ, anuria, nrụrụ akụrụ siri ike (nhichapụ creatinine (CC) erughị 30 ml / min.), Hyperkalemia, akpịrị ịkpọ nkụ (gụnyere nnukwu ọnụọgụ nke diuretics) oke nsia nke akwara, hypokalemia diski, ime, lactation, hypotension, afọ n’agbata afọ iri na asatọ (arụpụtaghị ọrụ na nchekwa), ụkọ lactase, galactosemia ma ọ bụ glucose / gal malabsorption syndrome. Na-eme ihe nkiri. Na mkpachapụ anya: mmiri-electrolyte ọbara nguzogide nsogbu (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), akwara abụọ akwara arter stenosis ma ọ bụ stenosis nke otu akụrụ akwara, ọrịa shuga ọrịa shuga, hypercalcemia, hyperuricemia na / ma ọ bụ gout, ihe ụfọdụ na-adịghị ala ala. mepụtara na ọgwụ ndị ọzọ, gụnyere ndị na - egbochi AP

Lorista N side effects

• N'akụkụ ọbara na sistem lymphatic: ugboro ugboro: anaemia, Shenlane-Genokha purpura. Na akụkụ nke sistemụ mgbochi: adịkarịghị: mmeghachi omume anaphylactic, angioedema (gụnyere ọrịị nke ogwooro na ire, na-akpata ihe mgbochi nke okporo ụzọ na / ma ọ bụ ọrịre nke ihu, egbugbere ọnụ, pharynx). Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: na - enwekarị isi ọwụwa, ọgbụgbọ na sistemu, ehighị ụra, ike ọgwụgwụ, adịghị ala: migraine. Site na sisitemu obi: otutu mgbe: orthostatic hypotension (based on dose), palpitations, tachycardia, di obere: vasculitis. Site na sistem iku ume: oge ​​mgbe: ụkwara, ọrịa iku ume nke elu, ọrịa pharyngitis, ọzịza nke mucosa nke imi. Site na eriri afọ: oge: afọ ọsịsa, dyspepsia, ọgbụgbọ, ọgbụgbọ, mgbu afọ. Site na sistemu ịba ọcha n'anya: adịkarịghị: ịba ọcha n'anya, ọrụ imeju na-arụ ọrụ. Site na anụ ahụ na abụba subcutaneous: ugboro ugboro: urticaria, itching skin. Site na usoro akwara na uru ahụ: oge: myalgia, azụ mgbu, ugboro ugboro: arthralgia. Ihe ndi ozo: otutu oge: asthenia, adighi ike, akwara isi, obi mgbu. Na-egosi ụlọ nyocha: ọtụtụ mgbe: hyperkalemia, ịba ụba nke ọbara haemoglobin na hematocrit (ọ bụghị ọgwụgwọ dị oke mkpa), na-adịghị ala ala: mmụba dị elu na serum urea na creatinine, adịkarịghị: ụba ọrụ nke imeju na enzymes bilirubin.

Ọnọdụ nchekwa

• chekwaa n temperature ulo oku okpomoku 15-25
• gbapụ ụmụaka

Kwa afọ, ọnụ ọgụgụ na-arịwanye elu nke ndị mmadụ na-ata ahụhụ site na mmepe nke ọrịa obi. Dabere na ọnụ ọgụgụ, n'oge na-adịbeghị anya, ọbụna obere ụmụaka echewo nsogbu a. Taa, enwere ọtụtụ ọgwụ na-enyere aka ịlụ ọgụ ọgụ nke ọbara mgbali elu. Otu n’ime ihe kachasị dị irè bụ Lorista N.

Lorista N bụ ọgwụ ejikọtara ọnụ nke nwere mmetụta hypotensive. Ihe ndị mejupụtara ya na-edozi ọbara mgbali elu ma na-enyere aka iwepu ọdịda obi. Mmetụta dị mma nke mbadamba nkume ahụ bụ nke ihe ndị bụ isi na - arụ ọrụ -. Ọ na - akpalite mgbochi nke ndị na - anabata angiotensin II na obi, arịa ọbara na akụrụ. N'ihi nke a, a na-achọpụta mbelata vasoconstriction.

N’adịghị ka Lorista

N'ime ụlọ ahịa ọgwụ Russia, ọtụtụ ngwaahịa ndị yiri ya na-ere otu mgbe - Lorista N na ọtụtụ ndị amaghị ihe dị iche n'etiti ha.

Isi ihe dị na nchikota ọgwụ. Na Lorista, losartan bụkwa isi ihe eji arụ ọrụ. Ọrụ nke mgbakwunye ndị ọzọ bụ ọrụ: ọka ọka, cellactose, steeti magnesium.

N’ime ụdị ọgwụ a ka mma na nganiihu H, ndepụta hydrochlorothiazide na-agbakwụnye. Ọ na - enyere aka belata ọkwa nke cortical ngalaba nke Na + reabsorption. Enweghịkwa mkpa iji aka ịhọrọ usoro ọgwụgwọ mbụ maka ndị ọrịa tozuru oke.

Ihe ozo di iche n'etiti ogwu ndia bu ugwo. Ọnụ ego nke Lorista dị obere ma dị 100-130 rubles. Banyere usoro eji eme ihe, ọgwụ abụọ ahụ na-enyere aka belata ọbara mgbali elu.

Anddị na ọnụego ọgwụ a

Ogwu a di n ’udidi ndi n’eme ka odo acho odo odo. Mgbe ụfọdụ enwere mbadamba nke agba akwụkwọ ndụ akwụkwọ ndụ. Ha dị obere nha ma baa uru n'ụdị, yabụ na -eme oriri nnabata dị ka o kwere mee. N’otu akụkụ enwere akara nkewa (Lorista ND, nke nwere nnukwu ọdịnaya nke akụrụngwa nọ n'ọrụ, ọ nọghị ya).

Mgbe ọ gafesịrị nyocha ahụ ma gakwuru onye ọkachamara, onye ọrịa ahụ nwere ike ịghọta ihe kachasị mma n'ọnọdụ ya - N ma ọ bụ ND. Ọ baghị uru ịkọwa onwe gị ọgwụgwọ ka ọ ghara imerụ anụ ahụ ahụ. Ọnụ ego ha bụ 230 rubles.

Mejupụtara, usoro nke ihe na akụrụngwa

Mbadamba ụrọ ọ bụla nwere ihe eji emepụta fim ma nwee: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), ọka ọka pregelatinized, MCC, magnesium stearate na lactose monohydrate. Ọzọkwa, enwere mbadamba ụrọ nwere oke ọdịnaya losartan (100 mg). A na-akpọ ha Lorista ND. A gbakwunye 25 mg nke hydrochlorodisiad na nchịkọta ha. Ngwa inyeaka nọgidere bụrụ otu.

Maka imepụta mkpuchi ihe nkiri, ndị na-emepụta na-eji talc, edo edo edo, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Ofzọ usoro ihe ndị dị n’ọrụ bụ iji belata ọbara mgbali elu ma belata ibu dị n’obi. Ihe ndị mejupụtara mbadamba nkume ndị ahụ na-atụnye ụba na-arụ ọrụ plasma renin, mbelata nke ọdịnaya potassium na mmelite na nzuzo nke aldosterone.

Ihe e ji mara ọgwụ ahụ bụ ọgwụ uricosuric. Ọ na - egbochi mmetụta anụ ahụ nke angiotensin II. Na hydrochlorothiazide, ihe ahụ na-ebelata hyperuricemia. Ọgwụ anaghị emetụta ugboro ole contractions nke akwara obi. Antihypertensive mmetụta a na-ebu site na mgbasawanye nke akwara. Mgbe awa 2-3 gachara, nsonaazụ pụtara ihe were otu ụbọchị.

Losartan na-agbadata nke ọma site na eriri afọ, ogo nke bioavailability bụ 32-33%. Ihe mejupụtara ya na protein protein. Ihe dị ka 58% nke ọgwụ ahụ sitere na ahụ ahụ, yana akwara, 35% na-ewepụtakwa ya na akụrụ. Mgbe abatasịrị, hydrochlorothiazide batara na protein protein (ihe dị ka 65%). N’ime awa 5-10 ka ahụ pụọ na mmamịrị.

Ihe ngosi na ike

Ọgwụ a na-arụ dị ka otu n’ime ihe mejupụtara usoro ọgwụgwọ siri ike na nchoputa nke ọbara mgbali elu. Ihe ngosi ndi ozo gunyere:

1. Mbelata ihe ize ndụ nke ịmalite ọrịa vaskụla na ọrịa obi.
2. Mwepu mgbaàmà na-adịghị mma nke nwere nnukwu hypertrophy ventricular.

Ọkpụkpụ hypertrophy

Lorista N nwere ọtụtụ contraindications, nke a ga-akwụ ụgwọ lebara anya pụrụ iche tupu iwere:

• akpịrị ịkpọ nkụ
• enweghị lactose n’ahụ,
• ngbaka
• gbasara akwara
• ọbara mgbali ala
• tụụrụ ime
• anabataghị onye ọ bụla ma ọ bụ anabataghị ihe ndị mejupụtara ya.

Ọzọkwa, enyeghị ọgwụ ahụ maka ụmụaka ndị gbara afọ 18. Na gout, ọrịa shuga, ụkwara ume ọkụ, ọrịa ọbara, a na-anabata ọgwụ ahụ, mana n'okpuru nlekọta siri ike nke dọkịta na-aga.

Medication -ụ ọgwụ onwe gị nwere ike ime ka ọnọdụ ahụ ka njọ. Tupu ị theụọ ọgwụ ahụ, ịkwesịrị ịchọpụta ụdị nrụgide edenye ya.

Ntụziaka maka ojiji

Emere ọgwụ a maka nchịkwa ọnụ, n'agbanyeghị nri oriri. Anabatachara ị withụ ọgwụ ọjọọ iji belata ọbara mgbali elu. Usoro onunu ogwu dabere na udiri oria ogwu.

Dabere na ntuziaka maka ojiji, yana ọbara mgbali elu kwa ụbọchị, a na-ahapụ ya ka ọ were 1 mbadamba. Usoro onunu ogwu kacha bu 2 PC. Ọ dị mkpa ka ọ dịkwuo ike ịbawanye ọgwụ a site n'aka dibịa na-aga ya.

Mgbe ị na-achọpụta ọbara mgbali elu ventricular, ọgwụ mbụ kwa ụbọchị bụkwa 50 mg, ya bụ, 1 mbadamba. Ke usenubọk m̀m in mbubreyo - enye ikenen̄ekede iyom.

Ndị ọrịa nwere mmasị ma ha drinkụọ ọgwụ ahụ maka ndụ ha ma ọ bụ na ha agaghị a .ụ. Iji mee ka nrụgide dozie ahụ na mgbaàmà nke ọrịa ahụ ịlaghachi azụ, ọ dị mkpa iji mezue usoro ahụ zuru ezu (ihe dị ka ụbọchị 30). Mgbe nke a gasịrị, dibịa ga-aga ga-eduzi nyocha ọzọ wee kọọ banyere omume ndị ọzọ. Ọ bụrụ na mwakpo ugboro ugboro, ịnwere ike ịme usoro ahụ ọzọ.

Ọ dị mkpa ịtụle mmekọrịta dị n'etiti ọgwụ a:

Mmetụta akụkụ na ị andụbiga mmanya ókè

Ọ bụrụ na ewere ọgwụ ahụ n'ụzọ na-ezighi ezi, nsonaazụ na-achọghị ka nwere ike ime (Isiokwu 2).

Mmetụta dị iche iche nwekwara ike ịpụta n'ụdị rashes na akpụkpọ ahụ, yana itching na-eso ya. N'ihe banyere ịdoụbiga mmanya ókè, onye ọrịa nwere:

• brasycardia / tachycardia,
• mbelata nke ọbara mgbali elu,
• hyponatremia,
• hypochloremia.

Ọ bụrụ n ’ihe ịrịba ama mbụ nke ịdoụbiga mmanya ókè pụtara, ọ dị mkpa ịkpọtụrụ ọkachamara. Ihe enyemaka mbu n'ọnọdụ dị otú a bụ lavage gastric. Ọzọkwa, onye ọrịa ga-achọ ọgwụgwọ Symptomatic.

Maka ọgwụgwọ nke ọrịa obi, yana ọbara mgbali elu, a na-ejikwa Lorista N. nọ n'ọnọdụ ndị ka ukwuu, mkpa a na-ebilite na ntinye nke otu akụkụ ụfọdụ.

Na mgbakwunye, ụfọdụ analogues dị ọnụ ala karịa Lorista N. Ndepụta nke ọgwụ nwere otu arụmọrụ na-arụ ọrụ gụnyere:

1. Co-Centor (50 mg). Ọnụ ego ahụ bụ 130 rubles.
2. (Nke 30). Enwere ike ịzụta ahịa ọgwụ maka 100-110 rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Tupu ị dochie ọgwụ dọkịta nyere gị, ọ dị mkpa ịkpọtụrụ ya, ka ị ghara ịkpasu nsogbu nke nsogbu.

Ngwakọta na ụdị ọgwụ ahụ

Mbadamba ihe mkpuchi site na odo na odo na-acha akwụkwọ ndụ na agba, oval, biconvex ubé, na-enwe ihe ize ndụ n'otu akụkụ, ụdị mbadamba dị na mpaghara obe bụ isi nke mbadamba ọcha.

Ndị pụrụ iche: stgelatinized steepụ - 34.92 mg, microcrystalline cellulose - 87.7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Ihe ndị mejupụtara ihe nkiri ahụ: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, quinoline odo (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (6) - ngwugwu nke kaadiboodu.
10 PC. - blisters (9) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Omume ọgwụ - hypotensive .

Mlọ ọgwụ

Lorista ® N - ọgwụ ejikọtara ọnụ, nwere mmetụta hypotensive.

Losartan. Nhọrọ antiotensin II na-anabata antagonist (ụdị AT 1) maka nchịkwa ọnụ, ọdịdị na-abụghị protein. Na vivo na in vitro losartan na ya na ihe ndi mmadu na - eme ka ihe ndi ozo na - eme ka ihe ndi ozo di ndu (EXP-3174) na - egbochi ihe anakpo physiologically di ukwu nke angiotensin II na ndi natara AT 1.

Losartan na-akpata esemokwu na-anabata ndị na-anabata ndị ọrụ AT 2 site na ịba ụba ọkwa nke angiotensin II.

Losartan adịghị egbochi ọrụ kininase nke abụọ, enzyme nke na-etinye aka na metabolism nke bradykinin.

Ọ na - ebelata OPSS, nrụgide dị na okirikiri nke “ọbara” na - erugharị n’ọbara, na - ebelata ibu mgbe ebusara ya, nwere mmetụta ọria.

Ọ na-egbochi mmepe nke hypertrophy myocardial, na-eme ka nnabata mmega ahụ nwee ndị ọrịa nwere nkụda mmụọ obi na-adịghị ala ala. Iwere losartan otu ugboro kwa ụbọchị na-eduga na mbelata dị ukwuu na SBP na DBP. Losartan na-ejikwa nrụgide ahụ na-achịkwa ụbọchị ahụ dum, ebe mmetụta antihypertensive kwekọrọ na ụda mmiri nke circadian. Mbelata ọbara mgbali elu na njedebe nke ọgwụ ahụ bụ ihe dịka 70-80% nke nsonaazụ ahụ dị elu nke ọgwụ ahụ, 5-6 awa mgbe nchịkwa gasịrị. Achọpụtaghị n ’ịba n’ ọrịa ahụ, losartan enweghị mmetụta ọmalịcha n’egwuregwu obi.

Losartan dị irè na ụmụ nwoke na ụmụ nwanyị, yana ndị agadi (karịa afọ 65) na ndị ọrịa na-eto eto (ndị dị n'okpuru afọ 65).

Hydrochlorothiazide. A ọrịa thiazide diuretic, nke mmetụta diuretic ya nwere bụ ihe jikọtara ya na mmebi nke reabsorption nke sodium, chlorine, potassium, magnesium, ion mmiri na nephron distal, na-egbu oge mkpụsị sọlfọ ion, uric acid. Ọ nwere antihypertensive Njirimara. Fọrọ nke nta ọ nweghị mmetụta ọ bụla na ọbara mgbali nkịtị.

Mmetụta ọgbụgba ahụ na-apụta mgbe awa 1-2 gachara, rutekarị mgbe ọ gachara 4, wee bido awa 6-12. Mmetụta antihypertensive na-apụta mgbe ụbọchị 3-4 gachara, mana ọ nwere ike were izu 3-4 iji rụpụta ezigbo ọgwụgwọ ọgwụgwọ.

Ihe ngbanwe

Hypersensitivity na losartan, na ngwaahịa ndị a na - enweta site na sulfonamides na akụkụ ndị ọzọ nke ọgwụ, anuria, nsogbu akụrụ siri ike (Cl creatinine 65 afọ) na ndị ọrịa na - eto eto (

Mlọ ọgwụ

Ọnọdụ pụrụ iche

• Taabụ 1 losartan potassium 100 mg hydrochlorothiazide 25 mg Ndị ọkachamara: pregelatinized stachi - 69.84 mg, microcrystalline cellulose - 175.4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Ngwakọta nke akpụkpọ ahụ ihe nkiri: hypromellose - 10 mg, macrogol 4000 - 1 mg, quinoline odo (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potassium 100 mg hydrochlorothiazide 12.5 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc. losartan potassium 100 mg hydrochlorothiazide 25 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12.5 mg Ihe ndị dị mkpa: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate Shell: hypromellose, macrogol 4000, quinoline acha odo odo (E104), titanium dioxide (E171), tal. losartan potassium 50 mg hydrochlorothiazide 12.5 mg Ndị ọkachamara: pregelatinized stachi, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Ihe mejupụtara Shell: hypromellose, macrogol 4000, quinoline odo odo (E104), titanium dioxide (E171), talc.

Ngosiputa Lorista N

• * Ọbara mgbali elu (nye ndị ọrịa gosiri ọgwụgwọ ọgwụgwọ). * Mbelata ihe ize ndụ nke ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na ogwe aka ekpe ventricular.

Lorista N contraindications

• Hypersensitivity na losartan, na ọgwụ ndị a na - enweta site na sulfonamides na akụkụ ndị ọzọ nke ọgwụ, anuria, nrụrụ akụrụ siri ike (nhichapụ creatinine (CC) erughị 30 ml / min.), Hyperkalemia, akpịrị ịkpọ nkụ (gụnyere nnukwu ọnụọgụ nke diuretics) oke nsia nke akwara, hypokalemia diski, ime, lactation, hypotension, afọ n’agbata afọ iri na asatọ (arụpụtaghị ọrụ na nchekwa), ụkọ lactase, galactosemia ma ọ bụ glucose / gal malabsorption syndrome. Na-eme ihe nkiri. Na mkpachapụ anya: mmiri-electrolyte ọbara nguzogide nsogbu (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), akwara abụọ akwara arter stenosis ma ọ bụ stenosis nke otu akụrụ akwara, ọrịa shuga ọrịa shuga, hypercalcemia, hyperuricemia na / ma ọ bụ gout, ihe ụfọdụ na-adịghị ala ala. mepụtara na ọgwụ ndị ọzọ, gụnyere ndị na - egbochi AP

Lorista H usoro onunu ogwu

• 100 mg + 25 mg 12.5 mg + 100 mg 12.5 mg + 50 mg 25 mg + 100 mg 25 mg + 100 mg 50 mg + 12.5 mg

Lorista N side effects

• N'akụkụ ọbara na sistem lymphatic: ugboro ugboro: anaemia, Shenlane-Genokha purpura. Na akụkụ nke sistemụ mgbochi: adịkarịghị: mmeghachi omume anaphylactic, angioedema (gụnyere ọrịị nke ogwooro na ire, na-akpata ihe mgbochi nke okporo ụzọ na / ma ọ bụ ọrịre nke ihu, egbugbere ọnụ, pharynx). Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: na - enwekarị isi ọwụwa, ọgbụgbọ na sistemu, ehighị ụra, ike ọgwụgwụ, adịghị ala: migraine. Site na sisitemu obi: otutu mgbe: orthostatic hypotension (based on dose), palpitations, tachycardia, di obere: vasculitis. Site na sistem iku ume: oge ​​mgbe: ụkwara, ọrịa iku ume nke elu, ọrịa pharyngitis, ọzịza nke mucosa nke imi. Site na eriri afọ: oge: afọ ọsịsa, dyspepsia, ọgbụgbọ, ọgbụgbọ, mgbu afọ. Site na sistemu ịba ọcha n'anya: adịkarịghị: ịba ọcha n'anya, ọrụ imeju na-arụ ọrụ. Site na anụ ahụ na abụba subcutaneous: ugboro ugboro: urticaria, itching skin. Site na usoro akwara na uru ahụ: oge: myalgia, azụ mgbu, ugboro ugboro: arthralgia. Ihe ndi ozo: otutu oge: asthenia, adighi ike, akwara isi, obi mgbu. Na-egosi ụlọ nyocha: ọtụtụ mgbe: hyperkalemia, ịba ụba nke ọbara haemoglobin na hematocrit (ọ bụghị ọgwụgwọ dị oke mkpa), na-adịghị ala ala: mmụba dị elu na serum urea na creatinine, adịkarịghị: ụba ọrụ nke imeju na enzymes bilirubin.

Mkparịta ụka ọgwụ ọjọọ

Dodoụbiga ya ókè

Ọnọdụ nchekwa

• chekwaa n temperature ulo oku okpomoku 15-25
• gbapụ ụmụaka

Kwa afọ, ọnụ ọgụgụ na-arịwanye elu nke ndị mmadụ na-ata ahụhụ site na mmepe nke ọrịa obi. Dabere na ọnụ ọgụgụ, n'oge na-adịbeghị anya, ọbụna obere ụmụaka echewo nsogbu a. Taa, enwere ọtụtụ ọgwụ na-enyere aka ịlụ ọgụ ọgụ nke ọbara mgbali elu. Otu n’ime ihe kachasị dị irè bụ Lorista N.

Lorista N bụ ọgwụ ejikọtara ọnụ nke nwere mmetụta hypotensive. Ihe ndị mejupụtara ya na-edozi ọbara mgbali elu ma na-enyere aka iwepu ọdịda obi. Mmetụta dị mma nke mbadamba nkume ahụ bụ nke ihe ndị bụ isi na - arụ ọrụ -. Ọ na - akpalite mgbochi nke ndị na - anabata angiotensin II na obi, arịa ọbara na akụrụ. N'ihi nke a, a na-achọpụta mbelata vasoconstriction.

N’adịghị ka Lorista

N'ime ụlọ ahịa ọgwụ Russia, ọtụtụ ngwaahịa ndị yiri ya na-ere otu mgbe - Lorista N na ọtụtụ ndị amaghị ihe dị iche n'etiti ha.

Isi ihe dị na nchikota ọgwụ. Na Lorista, losartan bụkwa isi ihe eji arụ ọrụ. Ọrụ nke mgbakwunye ndị ọzọ bụ ọrụ: ọka ọka, cellactose, steeti magnesium.

N’ime ụdị ọgwụ a ka mma na nganiihu H, ndepụta hydrochlorothiazide na-agbakwụnye. Ọ na - enyere aka belata ọkwa nke cortical ngalaba nke Na + reabsorption. Enweghịkwa mkpa iji aka ịhọrọ usoro ọgwụgwọ mbụ maka ndị ọrịa tozuru oke.

Ihe ozo di iche n'etiti ogwu ndia bu ugwo. Ọnụ ego nke Lorista dị obere ma dị 100-130 rubles. Banyere usoro eji eme ihe, ọgwụ abụọ ahụ na-enyere aka belata ọbara mgbali elu.

Anddị na ọnụego ọgwụ a

Ogwu a di n ’udidi ndi n’eme ka odo acho odo odo. Mgbe ụfọdụ enwere mbadamba nke agba akwụkwọ ndụ akwụkwọ ndụ. Ha dị obere nha ma baa uru n'ụdị, yabụ na -eme oriri nnabata dị ka o kwere mee. N’otu akụkụ enwere akara nkewa (Lorista ND, nke nwere nnukwu ọdịnaya nke akụrụngwa nọ n'ọrụ, ọ nọghị ya).

Mgbe ọ gafesịrị nyocha ahụ ma gakwuru onye ọkachamara, onye ọrịa ahụ nwere ike ịghọta ihe kachasị mma n'ọnọdụ ya - N ma ọ bụ ND. Ọ baghị uru ịkọwa onwe gị ọgwụgwọ ka ọ ghara imerụ anụ ahụ ahụ. Ọnụ ego ha bụ 230 rubles.

Mejupụtara, usoro nke ihe na akụrụngwa

Mbadamba ụrọ ọ bụla nwere ihe eji emepụta fim ma nwee: losartan potassium (50 mg), hydrochlorothiazide (12.5 mg), ọka ọka pregelatinized, MCC, magnesium stearate na lactose monohydrate. Ọzọkwa, enwere mbadamba ụrọ nwere oke ọdịnaya losartan (100 mg). A na-akpọ ha Lorista ND. A gbakwunye 25 mg nke hydrochlorodisiad na nchịkọta ha. Ngwa inyeaka nọgidere bụrụ otu.

Maka imepụta mkpuchi ihe nkiri, ndị na-emepụta na-eji talc, edo edo edo, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Ofzọ usoro ihe ndị dị n’ọrụ bụ iji belata ọbara mgbali elu ma belata ibu dị n’obi. Ihe ndị mejupụtara mbadamba nkume ndị ahụ na-atụnye ụba na-arụ ọrụ plasma renin, mbelata nke ọdịnaya potassium na mmelite na nzuzo nke aldosterone.

Ihe e ji mara ọgwụ ahụ bụ ọgwụ uricosuric. Ọ na - egbochi mmetụta anụ ahụ nke angiotensin II. Na hydrochlorothiazide, ihe ahụ na-ebelata hyperuricemia. Ọgwụ anaghị emetụta ugboro ole contractions nke akwara obi. Antihypertensive mmetụta a na-ebu site na mgbasawanye nke akwara. Mgbe awa 2-3 gachara, nsonaazụ pụtara ihe were otu ụbọchị.

Losartan na-agbadata nke ọma site na eriri afọ, ogo nke bioavailability bụ 32-33%. Ihe mejupụtara ya na protein protein. Ihe dị ka 58% nke ọgwụ ahụ sitere na ahụ ahụ, yana akwara, 35% na-ewepụtakwa ya na akụrụ. Mgbe abatasịrị, hydrochlorothiazide batara na protein protein (ihe dị ka 65%). N’ime awa 5-10 ka ahụ pụọ na mmamịrị.

Ihe ngosi na ike

Ọgwụ a na-arụ dị ka otu n’ime ihe mejupụtara usoro ọgwụgwọ siri ike na nchoputa nke ọbara mgbali elu. Ihe ngosi ndi ozo gunyere:

1. Mbelata ihe ize ndụ nke ịmalite ọrịa vaskụla na ọrịa obi.
2. Mwepu mgbaàmà na-adịghị mma nke nwere nnukwu hypertrophy ventricular.

Ọkpụkpụ hypertrophy

Lorista N nwere ọtụtụ contraindications, nke a ga-akwụ ụgwọ lebara anya pụrụ iche tupu iwere:

• akpịrị ịkpọ nkụ
• enweghị lactose n’ahụ,
• ngbaka
• gbasara akwara
• ọbara mgbali ala
• tụụrụ ime
• anabataghị onye ọ bụla ma ọ bụ anabataghị ihe ndị mejupụtara ya.

Ọzọkwa, enyeghị ọgwụ ahụ maka ụmụaka ndị gbara afọ 18. Na gout, ọrịa shuga, ụkwara ume ọkụ, ọrịa ọbara, a na-anabata ọgwụ ahụ, mana n'okpuru nlekọta siri ike nke dọkịta na-aga.

Medication -ụ ọgwụ onwe gị nwere ike ime ka ọnọdụ ahụ ka njọ. Tupu ị theụọ ọgwụ ahụ, ịkwesịrị ịchọpụta ụdị nrụgide edenye ya.

Ntụziaka maka ojiji

Emere ọgwụ a maka nchịkwa ọnụ, n'agbanyeghị nri oriri. Anabatachara ị withụ ọgwụ ọjọọ iji belata ọbara mgbali elu. Usoro onunu ogwu dabere na udiri oria ogwu.

Dabere na ntuziaka maka ojiji, yana ọbara mgbali elu kwa ụbọchị, a na-ahapụ ya ka ọ were 1 mbadamba. Usoro onunu ogwu kacha bu 2 PC. Ọ dị mkpa ka ọ dịkwuo ike ịbawanye ọgwụ a site n'aka dibịa na-aga ya.

Mgbe ị na-achọpụta ọbara mgbali elu ventricular, ọgwụ mbụ kwa ụbọchị bụkwa 50 mg, ya bụ, 1 mbadamba. Ke usenubọk m̀m in mbubreyo - enye ikenen̄ekede iyom.

Ndị ọrịa nwere mmasị ma ha drinkụọ ọgwụ ahụ maka ndụ ha ma ọ bụ na ha agaghị a .ụ. Iji mee ka nrụgide dozie ahụ na mgbaàmà nke ọrịa ahụ ịlaghachi azụ, ọ dị mkpa iji mezue usoro ahụ zuru ezu (ihe dị ka ụbọchị 30). Mgbe nke a gasịrị, dibịa ga-aga ga-eduzi nyocha ọzọ wee kọọ banyere omume ndị ọzọ. Ọ bụrụ na mwakpo ugboro ugboro, ịnwere ike ịme usoro ahụ ọzọ.

Ọ dị mkpa ịtụle mmekọrịta dị n'etiti ọgwụ a:

Mmetụta akụkụ na ị andụbiga mmanya ókè

Ọ bụrụ na ewere ọgwụ ahụ n'ụzọ na-ezighi ezi, nsonaazụ na-achọghị ka nwere ike ime (Isiokwu 2).

Mmetụta dị iche iche nwekwara ike ịpụta n'ụdị rashes na akpụkpọ ahụ, yana itching na-eso ya. N'ihe banyere ịdoụbiga mmanya ókè, onye ọrịa nwere:

• brasycardia / tachycardia,
• mbelata nke ọbara mgbali elu,
• hyponatremia,
• hypochloremia.

Ọ bụrụ n ’ihe ịrịba ama mbụ nke ịdoụbiga mmanya ókè pụtara, ọ dị mkpa ịkpọtụrụ ọkachamara. Ihe enyemaka mbu n'ọnọdụ dị otú a bụ lavage gastric. Ọzọkwa, onye ọrịa ga-achọ ọgwụgwọ Symptomatic.

Maka ọgwụgwọ nke ọrịa obi, yana ọbara mgbali elu, a na-ejikwa Lorista N. nọ n'ọnọdụ ndị ka ukwuu, mkpa a na-ebilite na ntinye nke otu akụkụ ụfọdụ.

Na mgbakwunye, ụfọdụ analogues dị ọnụ ala karịa Lorista N. Ndepụta nke ọgwụ nwere otu arụmọrụ na-arụ ọrụ gụnyere:

1. Co-Centor (50 mg). Ọnụ ego ahụ bụ 130 rubles.
2. (Nke 30). Enwere ike ịzụta ahịa ọgwụ maka 100-110 rubles.
3. Lozap 100 Plus (250 rubles).
4. Simartan-N.

Tupu ị dochie ọgwụ dọkịta nyere gị, ọ dị mkpa ịkpọtụrụ ya, ka ị ghara ịkpasu nsogbu nke nsogbu.

Ngwakọta na ụdị ọgwụ ahụ

Mbadamba ihe mkpuchi site na odo na odo na-acha akwụkwọ ndụ na agba, oval, biconvex ubé, na-enwe ihe ize ndụ n'otu akụkụ, ụdị mbadamba dị na mpaghara obe bụ isi nke mbadamba ọcha.

Ndị pụrụ iche: stgelatinized steepụ - 34.92 mg, microcrystalline cellulose - 87.7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1.75 mg.

Ihe ndị mejupụtara ihe nkiri ahụ: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, quinoline odo (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (6) - ngwugwu nke kaadiboodu.
10 PC. - blisters (9) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Mkpokọta ọgwụ antihypertensive. Losartan na hydrochlorothiazide nwere mmetụta antihypertensive na-agbakwunye, na-ebelata ọbara mgbali elu ka ukwuu karịa ihe ọ bụla mejupụtara iche.

Losartan bụ onye na - ahọta onye na - anabata angiotensin II na - anabata ya (ụdị AT 1) maka nchịkwa ọnụ. Na vivo na in vitro, losartan na ọgwụ ya na-arụ ọrụ na-arụ ọrụ na-E-3174 na-egbochi mmetụta physiologically pụtara nke angiotensin II na ndị na-anabata AT 1, n'agbanyeghị usoro njikọta ya: ọ na-ebute mmụba nke ọrụ renin ọbara na mbelata nke ịhapụ aldosterone na plasma ọbara. Losartan na-akpata esemokwu na-anabata ndị na-anabata ndị ọrụ AT 2 site na ịbawanye ụba nke angiotensin II.Ọ dịghị egbochi ọrụ nke kininase II, enzyme nke na-etinye aka na metabolism nke bradykinin. Ọ na-ebelata OPSS, nrụgide dị na mgbasa akwara, na-ebelata ibu mgbe myocardium, nwere mmetụta diuretic. Ọ na-egbochi mmepe nke hypertrophy myocardial, na-eme ka ndidi na-eme ka ndị ọrịa nwee nkụchi obi (chF). Inweta losartan 1 oge / ụbọchị na-eduga ná mbelata ọnụ ọgụgụ dị ukwuu systolic na ọbara ọbara diastolic.

Losartan na-achịkwa ọbara ọgbụgba n'ehihie, ebe mmetụta antihypertensive kwekọrọ na ụda mmiri nke circadian. Mbelata ọbara mgbali elu na njedebe nke ọgwụ ahụ bụ ihe dịka 70-80% nke nsonaazụ kachasị nke losartan, 5-6 awa mgbe mmesịrị. Onweghi onye weputara ya oria.

Losartan enweghị mmetụta ọgwụgwọ dị ukwuu n'ọbara obi, nwere mmetụta uricosuric na-adịchaghị ala ma na-adịte aka.

Hydrochlorothiazide- a thiazide diuretic nke mmetụta diuretic metụtara ya na mmebi nke reabsorption nke sodium, chlorine, potassium, magnesium, ion mmiri na nephron distal, na-egbu oge excretion nke calcium ion, uric acid. Ọ nwere mmetụta antihypertensive, ihe omume ya na-amalite n'ihi mgbasa nke arterioles. Fọrọ nke nta ọ nweghị mmetụta ọ bụla na ọbara mgbali nkịtị. Mmetụta ọgbụgba ahụ na-apụta mgbe awa 1-2 gachara, rute n'ogo mgbe awa anọ gachara wee ruo awa 6-12. Mmetụta antihypertensive kachasị na-apụta mgbe ụbọchị 3-4 gachara, mana ọ nwere ike were izu 3-4 iji rụpụta ezigbo ọgwụgwọ ọgwụgwọ.

N'ihi mmetụta diuretic, hydrochlorothiazide na-abawanye ọrụ plasma renin, na-akpali secretion nke aldosterone, na-eme ka ịbawanye ụba nke angiotensin II ma belata mkpokọta nke potassium na plasma ọbara. Recenata losartan na-egbochi mmetụta physiological nke angiotensin II na, n'ihi mgbachi nke mmetụta nke aldosterone, nwere ike inye aka belata mmebi nke potassium na-ewere ị aụ diuretic. Hydrochlorothiazide na-akpata ntakịrị mmụba nke mkpokọta uric acid n'ime ọbara, ngwakọta nke losartan na hydrochlorothiazide na-enyere aka belata ịdị ọcha hyperuricemia nke diuretic kpatara.

Mlọ ọgwụ

Aclọ ọgwụ ọgwụ nke losartan na hydrochlorothiazide na iji otu oge adịghị iche na ojiji ha na-eji monotherapy.

Mgbe nchịkwa ọnụ gasịrị, losartan na-etinye obi gị dum na ngọngọ nri. Ọ na - eme metabolism dị mkpa n'oge "ụzọ mbụ" site na imeju, na - akpụpụta ọgwụ ọgwụ na - eme ka ọ bụrụ metabolites na - arụ ọrụ metabolites (E-3174) na metabolites na - adịghị arụ ọrụ. Bioavailability dị ihe dịka 33%. A na-agbadata nkezi nke C max nke losartan na metabolite na-arụ ọrụ mgbe ọ gbasịrị 1 awa na mgbe awa 3-4 gachara. Losartan na metabolite ya na-arụ ọrụ na-ejikọ protein protein plasma (ọkachasị c) karịa karịa 99%. V d nke losartan bụ 34 lita. Ọ banyere n'ụzọ ọjọọ nke ukwuu site na BBB.

Losartan bụ metabolized iji mepụta metabolite na-arụ ọrụ (E-3174) (14%) na arụ ọrụ, gụnyere metabolites abụọ bụ isi mepụtara site na hydroxylation nke butyl group nke yinye na metabolite dị obere, N-2-tetrazolglucuronide. Mkpochapu plasma nke losartan na metabolite na-arụ ọrụ ya bụ ihe dịka 10 ml / sec (600 ml / min) na 0.83 ml / sec (50 ml / min), n'otu n'otu. Nwepu nke rensa na losartan na metabolite ya na-arụ ọrụ bụ ihe dịka 1.23 ml / sec (74 ml / min) na 0.43 ml / sec (26 ml / min). T 1/2 nke losartan na metabolite na-arụ ọrụ bụ awa 2 na awa 6-9, kwekọrọ. Ọ bụ nke dịkarịsịrị site n'iji eriri afọ mee ihe - 58%, akụrụ - 35%. Ọ dịghị akpọnwụ.

Mgbe etinyere ya na ọnụọgụ ruo 200 mg, losartan na metabolite na-arụ ọrụ ya nwere ọgwụ ọgwụ linear.

Mgbe nchịkwa ọnụ gachara, ntinye nke hydrochlorothiazide bụ 60-80%. A na - enweta C max na plasma ọbara n'ime elekere 1-5 site na nmalite Megide protein ndị dị n'ọbara plasma - 64%. Penetrates site na ihe mgbochi placental. Ara na mmiri ara. Hydrochlorothiazide adịghị metabolized ma akụrụ ya ewepụta ngwa ngwa. T 1/2 bụ 5-15 awa dịkarịa ala, 61% nke ọgwụ a na -ewere ọnụ na-agbanwe agbanwe n'ime awa 24.

Ọbara mgbali ọgụ (nye ndị ọrịa gosipụtara ọgwụgwọ ịgwọ ọrịa), belatara ọghọm ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na mgbali elu ventricular.

Ihe ngbanwe

Anuria, nnukwu nsogbu gbasara akụrụ (CC