Etu esi eji Fenofibrate?

Fenofibrate bụ ọgwụ eji egbugbere ọnụ nke ana - agwọ hypercholesterolemia na hyperlipidemia agwakọta. Mmetụta ahụ sitere na ntinye nke ndị na-anabata PPAR.. A na-ejikarị nri ọgwụ otu ugboro n'ụbọchị. Nsonaazụ ndị kachasị emetụta ya bụ isi ọwụwa na mgbu afọ. Fenofibrate nwere ike ime ka akpụkpọ ahụ nwee mmetụta na ìhè anyanwụ.

Ngwakọta na ụdị ntọhapụ

Fenofibrate dị n'ụdị akwa ntụ dị ọcha, nke a na-agbanyeghị na mmiri. A na - eme ka prodrug n'ime ahụ n'ime fenfibric acid dị n'ọrụ.

Ugbu a (2018), a na-eji fenofibrate micronized eme ihe n'ụzọ kachasị.

Na-adọrọ mmasị! Emepụtara ọgwụ ahụ site n'aka ụlọ ọrụ na-emepụta ọgwụ bụ አራትnier Pharma. Na United States, ọ bụrụla ọgwụ na-eweta ike dị ala na-ere ahịa n'ahịa.

Ngwongwo ogwu

PPARs bụ ndị nabatara ọgwụ nuklia nke ligands sitere n'okike ma ọ bụ roba rụọ ọrụ, ma na-abawanye ma ọ bụ na-egbochi ngosipụta nke mkpụrụ ndụ ihe nketa ụfọdụ. Enwere PPA alfa, beta na gamma ndị na-anabata ya. Ihe fọrọ nke nta ka ọ bụrụ fibrates niile na-ejikọ ọnụ na ndị na-anabata Alfa.

Isi mmetụta nke ọgwụ:

• Ọ na-egbochi ngosipụta nke apolipoprotein C3 (APOC3), nke n'aka nke na-egbochi lipoprotein lipase maka hydrolysis nke intravascular triglycerides (TG). PPAR-alpha na-abawanye ọrụ nke lipoprotein lipase, nke na-ebelata mkpokọta triglycerides n'ime ọbara.
• Na-eme ka njikọ nke APOA1, APOA2 na ya wee HDL
• N'oge ule nke ụlọ ọgwụ rụrụ na fenofibrate, cholesterol ọbara gbadara n'etiti 20 na 25%, HDL mụbara site na 10 ruo 30%
• Na-ebelata ngosipụta nke endothelin-1, nke bụ vasoconstrictor dị ike. Ọzọkwa, site na usoro a, fibrates na-ebelata ngosipụta nke cytokines, karịsịa IL-1 na IL-6, ya mere, ha nwere mmetụta mgbochi mkpali siri ike. A makwaara na iji PPAR-alfa, ụfọdụ fibrates nwere ike belata ngosipụta nke fibrinogen, yabụ ha nwere ike inwe mmetụta antithrombotic
• Na-eme ka mmiri ọgwụ cholesterol na-amụba, nke nwere ike inye aka na lithogenesis.

Oke plasma ịta (Cmax) na-enweta elekere awa 2-4 mgbe nchịkwa ọnụ gachara. Bioavailability belatara nke ukwuu ma ọ bụrụ na ejiri nri ahụ were nri. Mgbe nchịkwa ọnụ gasịrị, mmiri ọgwụ fenofibrate na-agbaze ngwa ngwa site na esterases n'ime metabolite na-arụ ọrụ - fenofibric acid. Fenofibric acid na Plasma albumin nwere mmekọrịta chiri anya (ihe karịrị 98%). Achọpụtaghị fenofibrate na-agbanweghi agbanwe na plasma. Ọgwụ abụghị ọgwụ maka cytochrome P450. Ọgwụ a adịghị etinye aka na metabolism metabolism.

A na-ewepụ ọgwụ ahụ n'ahụ ahụ tumadi na mmamịrị. A na - ekpochapucha ngwaahịa niile otu izu. A na - ewepu Fenofibrate n'ụdị fenofibric acid yana usoro glucuroconjugate ya. N'ime ndị ọrịa agadi, iwepu fenofibric acid anaghị agbanwe. Ọgwụ Pharmacokinetic mgbe otu ọgwụ na ọgwụgwọ na-aga n'ihu na-egosi enweghị mkpo. A naghị ekpochapụ Fenofibric acid site na usoro ọgwụgwọ. Ọkara ọkara bụ ihe dịka awa iri abụọ.

Ihe ngosi maka ojiji

Ọnụ ego Fenofibrate bụ 800 Russian rubles.

A na-eji Fenofibrate na mgbakwunye na nri ma ọ bụ ọgwụ ndị ọzọ (dịka mmega ahụ, ịbelata ibu) na ọgwụgwọ nke ụdị II, III, IV na V hyperlipidemia. Fenofibrate kwesịrị ka ewere ya dị ka ọgwụ nke abụọ. Enwere ike iji ọgwụ ahụ naanị mgbe ị na-etinyebiga ihe ókè nke lipids n'ime ọbara. Ekwesịrị iji ya mee ihe ọzọ ma ọ bụrụ na ihe ndị ọzọ na-arụ ọrụ si na statin otu anaghị arụ ọrụ ma ọ bụ na-egbochi ọgwụ.

Na nyocha, ọgwụgwọ fenofibrate belatara ugboro ugboro nkụchi obi na ọrịa obi. Agbanyeghị, ekwenyebeghị ya na ọgwụ nwere mmetụta dị mma na mmepe nke ọrịa obi.

Ntụziaka maka ojiji

Dịka ntuziaka ahụ si dị, a na-ewere fenofibrate otu ugboro n'ụbọchị. Nri oriri na-eme ya n'otu oge belata bioavailability nke ọgwụ. A na-atụ aro ị waterụ mbadamba ụrọ ewere mmiri.

Ekwesighi iji oge eji ime na inye ara ara, n'ihi na, dịka ntuziaka maka ojiji, ọgwụ nwere mmetụta teratogenic.

Contraindications, mmetụta ndị dị na ya, ịdoụbiga mmanya ókè, ịmekọrịta ọgwụ

Fenofibrate bụ contraindicated banyere hypersensitivity, nephropathy, imeju imeju, na-adịgide adịgide hepatic dysfunction, ọrịa nke gallbladder, gara aga photoallergic ma ọ bụ phototoxic mmeghachi omume. N'ọnọdụ ụcha akpụkpọ ahụ (mmeghachi nke fototoxic) na ịcha ọbara ọbara, ọnya na-agba agba, bloating na itching, ekwesịrị ịkwụsị ọrụ ndị na-arụ ọrụ.

A na-atụ aro ka ị gwa dọkịta gị ozugbo na mgbu, adịghị ike, na ọnya ahụ. Womenmụ nwanyị nwere ikike ịmụ nwa kwesịrị ị attentiona ntị na mgbochi dị irè n'oge ọgwụgwọ.

Fenofibrate na-akpata mgbakasị afọ na eriri afọ, na-eme ka enzymes imeju na-etoju nke njikọ nke homocysteine. Ọ na - ebute mgbu mgbu, ihe nfụkasị ahụ na - efe efe, gallstones, ma na - ebute ọkwa kinine creatine. Ọmụmụ ọgwụ nyocharala na ọgwụ nwere ike ibute nnukwu ịda mba na iji ogologo oge.

Mkparịta ụka ọgwụ ọjọọ ga-ekwe omume na ọgwụ anticoagulants, cyclosporine, ihe ndị metụtara hepatotoxic na mgbochi monoamine oxidase. Fenofibrate bụ ihe na-egbochi ụfọdụ cytochrome P450 isoforms.

Ihe analogues bu nke Fenofibrate: Fenofibrate Canon na Tricor.

Fonfibrat Canon

Emeputa - Canonfarm Production CJSC (Russia)

Ọnụahịa - site na 820 rubles

Nkọwa - mbadamba ihe mkpuchi nke eji eme ihe maka ọbara dị elu

Uru - na - ebelata ịta nke lipoproteins dị ala na nke dị ala, na - abawanye HDL ma nwee mmetụta antithrombotic na usoro ọgwụgwọ

Cons - na - ebute ike ọgwụgwụ, isi ọwụwa, ịda mba, eriri afọ, ịba ọcha n'anya na oke gbasara akụrụ

Emeputa - Recipharm Fontaine (France)

Ọnụahịa - site na 1200 rubles

Nkọwa - mbadamba ihe mkpuchi nke nwere fenofibrate nke micronized, nke a na-eji na-emeso oke cholesterol na triglycerides n'ime ọbara.

Uru - na - ebelata ịta nke LDL, VLDL, fibrinogen ma na - abawanye HDL. Ọdịnaya nke ihe nrịbama ọrịa ọgụ na uric acid n’arụ ọbara.

Cons - na - akpata dyspepsia, ụba enzymes imeju, jaundice, gallstones, rhabdomyolysis, drectfunction na nnukwu cephalgia.

Weputara udi ya na ihe mebere ya

A na-eme ọgwụ ahụ n'ụdị mbadamba membrane. Lọ ọgwụ ọ bụla nwere ọgwụ frifibrate nke 145, 160 ma ọ bụ 180 nke micronized. Dika eji eme ihe ndi ozo:

• mmiri ara ehi shuga
• microcrystalline cellulose,
• crospovidone
• hypromellose,
• sillodioxide dioxideated
• emecha
• suryum sury na scusum,
• stereta magnesium.

A na-eme ọgwụ ahụ n'ụdị mbadamba membrane.

Ihe mpụga ahụ bụ mejupụta talc, xanthan gum, titanium dioxide, polyvinyl mmanya na lecithin soya. Mbadamba ụcha nwere ọdịdị dị ogologo nke nwere ihe osise na akụkụ abụọ nke usoro onunu ogwu, na-egosi mkpụrụedemede mbụ nke ihe na-arụ ọrụ na usoro onunu ogwu.

Usoro nke ime ihe

Mbadamba ọgwụ Fenofibrate bụ otu nke ndị ọrụ hypoglycemic ma bụrụ ihe ewepụtara na fibroic acid. Ihe a nwere ikike imetụta ọkwa nke lipids n’ahụ.

Ngwongwo ogwu bu ihe sitere na RAPP-alpha na-aru oru (onye nnabata nke onye na - eme ngagharị peroxisis). N'ihi mmetụta na-akpali akpali, usoro metabolic nke mmebi abụba na mwepu nke plasma lipoproteins (LDL) dị ala na-eme ka ọ dịkwuo mma. A na - eme ka nguzobe nke apoproteins AI na AH wee pụta, n'ihi nke a na - abawanye nke lipoproteins densens (HDL) dị elu site na 10-30% na - eme ka lipoprotein lipase na - arụ ọrụ.

N'ihi mweghachi nke metabolism abụba n'ihe gbasara mmebi nke nguzobe nke VLDL, onyinye fenofibrate na - eme ka ntụpọ nke LDL dịkwuo elu, belata ọnụ ọgụgụ irighiri akwara dị ala na obere nha.

A na-abawanye ọkwa LDL n’ebe ndị ọrịa nọ n’ihe ize ndụ nke ibute ọrịa obi.

Ọgwụ na-enyere aka belata cholesterol site na 20-25% na triglycerides site na 40-55%. Na ọnụnọ nke hypercholesterolemia, ọkwa cholesterol metụtara LDL na-agbadata ruo 35%, ebe hyperuricemia na atherosclerosis belatara na mkpokọta uric acid n'ime ọbara site na 25%.

Mlọ ọgwụ

Mgbe a na -ekwu ya ọnụ, a na-etinye micronized fenofibrate n'akụkụ proximal nke obere eriri afọ site na iji microvilli, site na ebe ọ na-abanye n'ime arịa ọbara. Mgbe ọ batara na eriri afọ, ihe ahụ na - arụ ọrụ bara uru ozugbo nye fenofibroic acid site na hydrolysis na esterases. Ngwa ahịa ire ere na-erute ọkwa plasma kachasị n'ime awa 2-4. Nri ọnụego nnabata na bioavailability anaghị emetụta n'ihi nanoparticles.

Mgbe ọ batara na eriri afọ, ihe ahụ na - arụ ọrụ bara uru ozugbo nye fenofibroic acid site na hydrolysis na esterases.

N'ime ọbara ọbara, akụrụngwa na-arụ ọrụ na-ejikọ plasma albumin site na 99%. Ọgwụ a adịghị etinye aka na metabolism metabolism. Nkeji ọkara ndụ dị ka elekere iri abụọ. N'oge ule nke ụlọ ọgwụ, enweghi ọnọdụ nke ịchịkọta ma otu ma ọ bụ ịchịkwa ọgwụ ogologo oge. Ọkpụkpụ anụ ahụ adịghị arụ ọrụ. A na-ewepụ ọgwụ ahụ n'ụdị fenofibroic acid kpamkpam n'ime ụbọchị 6 site na usoro urinary.

Ihe ngbanwe

Edeghị ọgwụ ahụ n'ihi ọgwụ mgbochi siri ike:

• hypersensitivity na fenofibrate na ihe ndi ozo eji aru aru nke ogwu.
• ọrịa imeju
• nnukwu nsogbu gbasara akụrụ,
• ụyọkọ galactosemia na fructosemia, ụkọ nke lactase na sucrose, glucose na galactose na-emetụta ya,
• Akụkọ banyere ọrịa akwara ọrịa,
• mmetụta ọkụ ka ejiri ya na Ketoprofen ma ọ bụ fibrates ndị ọzọ,
• usoro ọnya na ọnya mmanụ.

Edeghị ọgwụ a maka ọgwụ ụyọkọ galactosemia.
Edeghị ọgwụ a maka ọrịa imeju.
Edeghị ọgwụ a maka ọgwụ mkpụrụ ndụ ihe nketa.
Edeghị ọgwụ a maka nnukwu ọrịa gbasara akụrụ.
Edeghị ọgwụ ahụ maka ọrịa akwara maka mmerụ akuko.
Edeghị ọgwụ a maka usoro pathological na gallbladder.

Ndị nwere mmeghachi omume anaphylactoid na ahụịkere na ahụekere na -ewe ahụ ekwesịghị ị theụ ọgwụ.

Ndị na-ahụ maka ọgwụ, INN, akporo

Fenofibrate bụ otu ndị pụrụ iche - ọgwụ na-ebelata mkpụrụ ndụ nke a na-eme na fibroic acid. Ọgwụ dị otú ahụ na-enwe ike belata mkpokọta cholesterol nke "ọjọọ" n'ọbara ma belata ọkwa nke triglycerides.

A na-eji ọgwụ ahụ eme ihe iji belata mkpokọta lipids, nchịkọta buru ibu nke na-emetụta ahụike mmadụ. A na - enye ya oge mgbe maka ndị ọrịa nwere ọrịa mellitus, yana ọrịa nke obi na akwara ọbara (dịka ọmụmaatụ, cardiac ischemia, atherosclerosis) iji mezie ọkwa nke lipids.

INN bụ Fenofibrate, ebe ọ bụ ihe mejupụtara ọgwụ ahụ ma na-ekpebi usoro ọrụ ya na ahụ.

Mwepụta wepụtara, ọnụ ahịa na Russia

A tọhapụrụ ọgwụ ahụ n'ụdị mbadamba ụcha nwere agba ọcha, ọdịdị gbara ya gburugburu na warara nkewa. Mbadamba ụrọ nke ọ bụla nwere otu iko na-arụ ọrụ nke 145. A na-akwakọba ha na blister plastic maka iberibe 7, 10 ma ọ bụ 15. Na mkpokọta, n'ime igbe kaadiboodu enwere 10 mbadamba iri.

Ọnụahịa ahụ dabere na ọnụọgụ mbadamba dị na ngwugwu ahụ, yana ebe ịzụrụ ọgwụ ahụ. A na-egosi ọnụ ahịa nke otu ngwugwu nke mbadamba 30 mbadamba 145 nke ọgwụ ọgwụ na nnukwu obodo Russia na tebụl.

A na-enye ọnụ ahịa kachasị ọnụ site na ndị ahịa ọgwụ n'ịntanetị. N'ebe ahụ ị nwere ike ịtụ nnyefe ngwa ngwa ozugbo n'ụlọ gị.

Ihe mejuputara ihe

Akụkụ bụ isi nke ọgwụ ahụ bụ fenofibrate. A na-akpọ ya dị ka ọgwụ fibroic acid (fibrates). Otu mbadamba nwere 145 mg nke ihe a. Ọzọkwa, ihe mejupụtara ọgwụ ahụ gụnyere ihe ndị dị otú ahụ - cellulose, magnesium stearate, povidone, mannitol, stachi, silicon dioxide. Ha nwere ọrụ inyeaka.

Ngwongwo ọgwụ

Fenofibrate nwere ike ime ka ụfọdụ ndị na-anabata Alfa na-anabata ya (RAPP). Nke a na - ebute ịba ụba lipolysis na iwepu lipoproteins dị ize ndụ dị ala, nke nwere ike ịchịkọta ma tinye ya na mgbidi nke arịa ọbara, na - akpata nsonaazụ na-adịghị mma. N'okwu a, mmetụta ndị a na-ahụ:

• ibelata triglycerides na cholesterol dị njọ,
• belata na uric acid (mmetụta uricosuric),

njikọ nke platelet agakọ (mgbochi nke thrombosis),

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ kpamkpam na eriri afọ mgbe awa anọ gachara. Ọ bụrụ na ejiri ya n’usoro, mgbe ahụ ịta n’ọbara nke ihe ahụ dị arụ ọrụ na-agbanwe agbanwe. Fenofibrate na - ejikọ protein protein niile.

N'ime usoro nhazi ya a na-emepụta acid fenofibroic. Na metabolism metabolism adịghị eso. Ntụrụndụ na-aputa site na akụrụ. A na-ahụ ndụ ndụ ọkara ka elekere iri abụọ na asatọ gasịrị. Ọ ga-ewe ihe dị ka ụbọchị isii iji kpochapụ ngwaahịa nke fenoforbit metabolites kpamkpam.

Ihe ngosi na ike

Edere ọgwụ iji belata ọkwa nke triglycerides na cholesterol dị ala dị ala na ọrịa ndị dị ka:

Ysgwakọta dyslipidemia. Ọ na-ebute oria ọtụtụ mgbe:

• ọrịa shuga mellitus
• ischemia
• Usoro atherosclerotic n'ime akwara ma ọ bụ akwara akwara akwara,
• abdominal artery aneurysm,
• nsogbu ndị ọzọ. A na-ejikarị ọgwụ ahụ eme ihe na njikọ site na iji statins iji belata ọdịnaya nke triglycerides ma mee ka ọkwa nke HDL (cholesterol bara uru).

Ọ bụ dibia bekee na-ekpebi oge ọ ga-anọ na usoro ọgwụgwọ. Tupu ịkọwa ọgwụ, ị kwesịrị ijide n'aka na onye ọrịa ahụ enweghị ọgwụ mgbochi dị otú a:

• onye anabataghi ya maka ihe mejuputara ogwu ahu.
• nnukwu nsogbu gbasara akwara
• hypersensitivity na fibrates na Ketoprofen,
• ihe mgbochi ọbara,
• adịghị ala ala ma ọ bụ ọrịa pancreatitis (nke ọzọ abụghị nke kpatara ọbara mgbali elu),
• umuaka na umuaka,
• oge GW,
• tụụrụ ime
• arụ ọrụ imeju (cirrhosis).

Anwaleghị ọgwụ ahụ n'ahụ ụmụaka, ụmụ nwanyị dị ime, na ndị nne na-enye nwa ara. Yabụ, amabeghị ihe nwere ike ịkpatara ndị mmadụ ụdị nsogbu a. Ebe ọ bụ na fenofibrate nwere ike ịbanye na Plasenta na banye na mmiri ara, a gaghị atụ aro iji ya ka ọ ghara imerụ nwa ahụ.

Site na ịkpachapụ anya na oke nlekọta nke dọkịta, a na-eji ọgwụ ahụ maka hypothyroidism, ọrịa gbasara akụrụ, yana maka ọgwụgwọ ndị ọrịa agadi na ndị na-a abuseụbiga mmanya ókè.

Ntụziaka maka ojiji

Ọ dị mkpa iji fenofibrate n'ụzọ ziri ezi. Nke a ga - enyere ntuziaka maka ojiji aka, nke na - atụ aro:

1. Were mbadamba nkume ndị ahụ n'ime mmiri na-ata ata.
2. A isụ ọgwụ na-a drunkụ mmanya otu ugboro n’ụbọchị, na-ejikọ ya na nri a na-eri (ya mere, ọ na-etinye gị obi gị ụtọ).
3. Usoro ọgwụgwọ nke ọgwụ maka ọrịa dị iche iche bụ 145 mg kwa ụbọchị. Ọrịa anaghị eme mgbanwe ọ bụla maka ndị okenye.

Ekwesịrị iji Fenofibrate ogologo oge. N'okwu a, a ga-ahụrịrị usoro nri hypocholesterol pụrụ iche.

Mgbe oge ụfọdụ gasịrị (ihe dị ka ọnwa 3 mgbe ịmalite ọgwụgwọ), a ga-enyocha ọbara onye ọrịa iji hụ ọnọdụ dị mma. Ọ bụrụ na egoghị nke a, ịkwesịrị idozi ọnya ma ọ bụ gbanwee usoro ọgwụgwọ.

Mkparịta ụka ọgwụ ọjọọ

Enwere ike iji ọgwụ ahụ mee ihe na njikọta na ọgwụ niile. Lee ihe atụ ụfọdụ nke mmekọrịta ya na ọgwụ ndị ọzọ:

1. Site na nhazi oge a na anticoagulants, a na-eme ka mmetụta ha kawanye mma. Nke a nwere ike ibute ọbara ọgbụgba. Ọ bụrụ na ịchọrọ iji ha n'otu oge, mgbe ahụ ị ga-ebelata usoro nke anticoagulants ugboro atọ.
2. Fenofibrate nwere cyclosporine, mgbe ejikọtara ọnụ, ọ na-akpalite mmebi nke ọrụ akụrụ.
3. Iji ya na fibrates ndị ọzọ eme ihe na-abawanye ohere ị nwere ịmalite mmerụ ahụ na uru akwara.

Ntụziaka pụrụ iche

Ọ dị mkpa ịmụ ntuziaka pụrụ iche tupu ị usingụ ọgwụ. Themfọdụ n’ime ha bụ:

1. Ọgwụ ahụ adịghị arụ ọrụ ma ọ bụrụ na ị wepụghị ọrịa ndị na-akpalite mmụba nke ọkwa lipid.
2. Mgbe ị na-a theụ ọgwụ ahụ, ị ​​kwesịrị iso nri nwere obere cholesterol dị ala.
3. Enwere ike inyocha ịdị irè ọgwụgwọ site na nsonaazụ nyocha ọbara maka ọdịnaya nke mkpokọta cholesterol, LDL, triglycerides.
4. Ọ bụrụ na onye ọrịa ahụ na-a drugsụ ọgwụ ọgwụ homonụ, mgbe ahụ i kwesịrị ịchọpụta ma mmụba nke ọkwa lipid abụghị ihe na-akpata ahaghị n ’ịba uru nke homonụ.
5. N'ime afọ mbụ nke ị theụ ọgwụ ahụ, a na-atụ aro ka ị nyochaa ọkwa nke transminases hepatic (ALT na AST).

Standkpụrụ ALT na AST

Usoro ndị dị otú a nwere ike iwelie arụ ọrụ ọgwụ ike, ma gbochie mmepe mmepe nke mmeghachi omume na nsogbu ndị na-adịghị mma.

Mmetụta ọghọm, ị symptomsụbiga ọ symptomsụ ókè

Ogwu nwere mmetụta ndi ozo zuru ezu. Ọtụtụ mgbe ha na-ebili n'ihi ojiji na-ekwesịghị ya. N'okwu a, ndị ọrịa nwere ike inweta:

• nsogbu digestive, nke gosipụtara site na ọgbụgbọ, ọgbụgbọ, flatulence, mgbu afọ, afọ ọsịsa,
• ọria aru
• ịkpụzi okwute n'ime dule dule,
• mmepe nke ịba ọcha n'anya (gosipụtara site na ọrịa jaundice, itching skin),
• spasm, ike ọgwụgwụ na ọnya,
• abawanye na sel ọbara ọcha na haemoglobin,
• isi ọwụwa
• imebi arụmọrụ,
• thromboembolism, leukocytosis,
• nnukwu akwara ọdịda
• usoro mbufụt ke ngụgụ
• ntutu isi
• Ihe nfụkasị ahụ na anụ ahụ n'ụdị nke ọbara ọbara, itching, rashes, urticaria,
• fotophobia.

Do Overụbiga mmanya ókè dị ụkọ. N'okwu a, ekwesịrị ịkpọga onye ọrịa n'ụlọ ọgwụ. Ha na-eme ọgwụgwọ Symptomatic. Ọ gaghị ekwe omume ịdọrọ ọgwụ ahụ site na ọgwụgwọ metụtara ọgwụgwọ.

Uzo di iche

Fenofibrate na-ezo aka n'ụkpụrụ hypoglycemic. Ihe analorọ ya nwere otu ihe eji arụ ọrụ. Ndị kasị ewu ewu na ha:

1. Tricor bụ ihe dị oke ọnụ karịa, mana ọgwụ dị elu sitere na France.
2. Lipantil bụ ngwaahịa French nke nwere 200 mg nke fenofibrate na mbadamba 1.
3. Exlip bụ ọgwụ ntọhapụ nke ndị Turkey nwere 250 mg nke fenofibrate.

Drugsfọdụ ọgwụ nwere ihe ndị ọzọ, mana ha nwere otu mmetụta. Themfọdụ n’ime ha bụ:

1. Atorvacor. Ọgwụ ahụ nwere ọgwụ atorvastatin nọ n'ọrụ ma bụrụ ihe mgbochi nke HMG-CoA reductase. A na-eji ya maka hyperlipidemia.
2. Livostor. Ngwaahịa a nwekwara atorvastatin. Ọ bụ ọgwụ dịtụ ọnụ ala iji belata cholesterol ọbara.
3. Ihe eji agwu Tulip. Ọ bụ ụlọ ọrụ na-emepụta ọgwụ Sandoz dị na Poland. Atorvastatin dị ka ihe na-arụ ọrụ.

A na-eji ego ndị dị otú ahụ maka ntachi obi na fenofibrate. Kenye otu analog ihe ozo ma obu ozo.

Nyocha nke ndị dọkịta na ndị ọrịa

Iji nyochaa ịdị irè nke ọgwụ ahụ, ọ dị mkpa ịmata ihe ndị dọkịta na ndị ọrịa ha na-ekwu banyere Fenofibrate. Nke a bụ ụfọdụ ezigbo nyocha:

Ọgwụ Fenofibrate bụ ọgwụ dị irè maka ịgwọ ọrịa hyperlipidemia. Uru ya dị na mkpokọta ihe arụ ọrụ n'ime ọbara, nke na-eduga na nsonaazụ na-adịgide adịgide - mbelata LDL na triglycerides.

Uzo esi ewere Fenofibrate

A na-ewere mbadamba n'echeghị ata. Ndị ọrịa toro eto kwesịrị ị toụ 145 mg ọgwụ ọjọọ kwa ụbọchị. Mgbe ị na-agbanwe site na usoro onyunyo nke 165, 180 mg gaa na mkpụrụ ọgwụ kwa ụbọchị nke 145 mg, ọ dịghị achọ ịgbatịzi ụkpụrụ kwa ụbọchị.

A na-atụ aro ị drugụ ọgwụ ahụ ogologo oge megide ndabere nke usoro ọgwụgwọ nri kwesịrị ekwesị. Ekwesịrị ka ndị dibịa bekee nyochaa ọgwụ ịgwọ ọrịa ga-arụ ọrụ nke ọma dabere na ọdịnaya nchịkwa ọbara ahụ.

A na-ewere mbadamba n'echeghị ata.

Sistemụ akwara Central

Ehihie na isi ọwụwa nwere ike ibute nsonaazụ nsị na akwara.

Site n'iji ọgwụ ọjọọ eme ihe na-adịghị mma, enwere ike ịmetụta akụkụ ya n'ụdị ihe ọdịdọ.
Site n'iji ọgwụ ọjọọ eme ihe n'ụzọ na-ezighi ezi, mmetụta ọzọ nwere ike ịpụta n'ụdị mgbu olu.
Site n'iji ọgwụ ọjọọ eme ihe na-ezighi ezi, mmetụta ọzọ nwere ike ịpụta n'ụdị ihe ọkụ ọkụ na anụahụ.
Site n'iji ọgwụ ọjọọ eme ihe n'ụzọ na-ezighi ezi, mmetụta ọzọ nwere ike ịpụta n'ụdị mmụba nke mkpụrụ ndụ ọbara ọcha n'ime ọbara.
Site n'iji ọgwụ ọjọọ eme ihe na-ezighi ezi, mmetụta ọzọ n'ụdị afọ ọsịsa nwere ike pụta.
Site n'iji ọgwụ ọjọọ eme ihe n'ụzọ na-ezighi ezi, mmetụta ọzọ nwere ike ịpụta n'ụdị nke vomiting.
Site n'iji ọgwụ ọjọọ eme ihe na-ezighi ezi, mmetụta ọzọ nwere ike ịpụta n'ụdị ntutu isi.

Site na usoro mkpụrụ ndụ ihe nketa

Onweghi mgbanwe na-adighi mma n’omume nke usoro olulu.

Ọtụtụ mgbe, ọnya anụ ahụ, ọnụnọ (nwute ọkụ), itching ma ọ bụ hives nwayọ nwayọ ruo obere. N'ọnọdụ ndị a na-adịghị ahụkebe, ntutu na-emebi, ọdịdị nke erythema, blisters ma ọ bụ nodules anụ ahụ na-ejikọta n'okpuru radieshon ultraviolet.

Mmetụta ikike ịchịkwa usoro

Inweta Fenofibrate anaghị emetụta ịta ahụhụ, mmeghachi omume anụ ahụ na nke uche, ya mere, n'oge ọgwụgwọ Lipid na-ebelata, ịnya ụgbọ ala na ịrụ ọrụ na ngwaọrụ ndị nwere mgbagwoju anya.

N'oge ị ofụ ọgwụ ahụ, a na-anabata ịkwọ ụgbọ ala ma jiri ngwaọrụ ndị dị mgbagwoju anya rụọ ọrụ.

Jiri n'oge ime na lactation

Na omumu ihe omumu banyere umu anumanu, ahughi ihe teratogenic. N'ime nyocha ndị a kapịrị ọnụ, edere nsị na ahụ nne ya na ihe ize ndụ nye nwa ebu n’afọ, ya mere, ọgwụ a ka ewere ya naanị ma ọ bụrụ na mmetụta dị mma ọ dịịrị nwanyị dị ime karịrị ihe nhụjuanya intrauterine n’ime nwata ahụ.

A na-ahapụ ịụ ara ara n'oge ọgwụgwọ.

Cribdebere Fenofibrate Childrenmụaka

A naghị akwado ọgwụ ahụ maka ụmụaka na ndị na-eto eto na-erubeghị afọ 18 n'ihi enweghị ozi gbasara mmetụta Fenofibrate na uto na ahụ.

A naghị akwado ọgwụ ahụ maka ụmụaka na ndị na-eto eto na-erubeghị afọ 18.
Cance canceụ nwa ara n’oge a na-a withụ ọgwụ a ka akagbuola.
Theụ ọgwụ n’oge afọ ime bụ naanị ma ọ bụrụ na mmetụta dị mma ọ dịịrị nwanyị dị ime karịrị ihe ize ndụ intrauterine dị n’ime nwata ahụ.

Dodoụbiga ya ókè

Onwebeghi ọnọdụ ịdoụbiga mmanya ókè n'ihi ị drugụ ọgwụ ọjọọ. Onweghi ihe puru iche ajuju idozi ya. Ya mere, ọ bụrụ na onye ọrịa nwere otu oke ọgwụ dị elu malitere inwe mmetụta na-arịa ọrịa, ịka njọ ma ọ bụ nsonaazụ ya, ọ dị mkpa ịchọ enyemaka ahụike. N ’ụlọ ọgwụ, a na-ewepụ ihe ngosipụta nke usoro ị symụbiga mmanya ókè.

Mmekọrịta na ọgwụ ndị ọzọ

Mgbe ị na-ejikọ fenofibrate na ọgwụ anticoagulants maka nchịkwa ọnụ, ịdị irè nke ọgwụ a na-atụle na-abawanye. Site na mmekorita a, ihe ize ndụ ọbara ọgbụgba na-abawanye n'ihi nchụpụ nke anticoagulant site na protein protein plasma.

Site n'iji ihe ndị na-egbochi HMG-CoA reductase na-egbochi, ihe egwu nke nsonaazụ nsí na akwara olu na-abawanye, yabụ ọ bụrụ na onye ọrịa ahụ ewere statins, ọ dị mkpa ịkagbu ọgwụ ahụ.

Cyclosporine na-eme ka akụrụ na-emebi emebi, yabụ mgbe ị na-ewere Fenofibrate, ị ga-enyocha ọnọdụ nke anụ ahụ mgbe niile. Ọ bụrụ na ọ dị mkpa, a ga-akagbu ijikwa ọgwụ hypolipidem.

Mmanya ndakọrịta

Ekwesighi ị .ụ mmanya na-egbu egbu n'oge ọgwụgwọ ya. Mmanya Ethyl na-ebelata mmetụta ọgwụgwọ nke ọgwụ ahụ, na-eme ka mmetụta utịp ke mkpụrụ ndụ imeju, akwara ndị dị n’ahụ na mgbasa ọbara.

Analogues nke ọgwụ ahụ nwere ọgwụ ọgwụ nwere otu ụdị arụmọrụ:

• Ihe omumu
• Atorvacor
• Lipantil
• Cyprofibrate,
• Mpempe akwụkwọ Canon Fenofibrate,
• Livostor
• Nkeji,
• Trilipix.

A na-agbanye ya na ogwu ozo emechaa mgbe nyochachara ogwu.

Ntụziaka aghụghọ Lipantil 200 M nkuzi Phenofibrate CANON

Ọnọdụ nchekwa maka ọgwụ

Ọ na-atụ aro ịchekwa ọgwụ ahụ na okpomọkụ ruo 25 + Celsius C n'ebe nkụ, adịghị anya site na ìhè anyanwụ.

Ọ na-atụ aro ịchekwa ọgwụ ahụ na okpomọkụ ruo 25 + Celsius C n'ebe nkụ, adịghị anya site na ìhè anyanwụ.

Nyocha Fenofibrate

Enwere okwu na-agba ume nke ndị na-ahụ maka ọgwụ na ndị ọrịa.

Olga Zhikhareva, dibia bekee, Moscow

Irè n'ọgụ megide elu triglycerides. Ana m akwado iji maka ụdị IIa, IIb, III na hyperlipoproteinemia. N'ime usoro ọgwụgwọ, ana m edepụta oge nchịkwa na usoro onunu ogwu n'otu oge. Enweghị mmetụta ọ bụla a hụrụ. Ọ nweghị mmetụta akpọsa na belata cholesterol.

Afkasy Prokhorov, onye na-ahụ maka nri na-edozi ahụ, Yekaterinburg

N'iburu oke ibu na cholesterol dị elu, fenofibroic acid na-enyere aka nke ọma. Karịsịa na ịdị ala nke mmega ahụ na nri dị ala. N'oge usoro ọgwụgwọ, ana m akwado ịhapụ omume ọjọọ ma sororo ndụmọdụ ndị dọkịta ka ọ nwekwuo arụmọrụ.

Nazar Dmitriev, onye gbara afọ 34, Magnitogorsk

Ezi usọbọ. Lipids bụ 5.4. N'iji Fenofibrate mee ihe mgbe niile, ogo abụba belatara ruo 1.32. Borderline dị 1.7. Enweghị mmetụta ọ bụla akọwapụtara.

Anton Makaevsky, onye gbara afọ 29, St. Petersburg

O were ihe dị ka otu afọ kama Torvacard n'ihi ọdịnaya dị ala nke HDL. Mgbe ọnwa 4-5 nke nchịkwa gasịrị, mwakpo ọgbụgbọ na mgbu n'ime akwara dị elu malitere ịpụta. Mgbe ọnwa 8-9 gachara, ha rụrụ ọrụ ịwa ahụ iji wepu ọnya afọ. A hụrụ viscous bile na nkume rụrụ arụ. Mgbe ọgụ ahụ mechara, ọgụ ahụ kwụsịrị.

Mikhail Taizhsky, 53 afọ, Irkutsk

Ọgwụ dụrụ mmanya iji mee ka mgbidi vaskụla sikwuo ike, mana enweghị m ike ikwu banyere ihe ahụ. A naghị enwe mmetụta olu. Site n'enyemaka nke ọgwụ ahụ, ịdị arọ belatara n'ihi agụụ, mana akpụkpọ ama ama nke ukwuu. Chọgharị ọrụ achọrọ. Enwere m afọ ojuju n'ihe si na ya pụta.