Metformin-Teva analogues
Peeji a na-enye ndepụta nke ihe analogues Metformin-Teva niile mejupụtara yana ngosipụta maka ojiji. Ndepụta analogues dị ọnụ ala, ị nwekwara ike ịtụle ọnụ ahịa dị na ụlọ ahịa ọgwụ.
- Atụmatụ Metformin-Teva dị ọnụ ala karịa:Ọrịa
- Analogue kacha ewu ewu nke Metformin-Teva:Metformin
- Nhazi ATX: Metformin
- Ngwaọrụ mejupụtara / ihe mejupụtara: metformin
| # | Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|---|
| 1 | Ọrịa metformin Analogue na ihe mejuputara ma gosiputa ya | 12 nkp | 15 UAH |
| 2 | Metformin metformin Analogue na ihe mejuputara ma gosiputa ya | 13 nkp | 12 UAH |
| 3 | Reduxin Met metformin, sibutramine Analogue na ihe mejuputara ma gosiputa ya | 20 nkp | -- |
| 4 | Metformin Canon metformin, ovidone K 90, stachi ọka, crospovidone, magnesium stearate, talc Analogue na ihe mejuputara ma gosiputa ya | 26 nkp | -- |
| 5 | Analog Mpempe na Akwukwo | 37 nkp | -- |
Mgbe ị na-agbakọ ọnụ ego ahụ Metformin-Teva na-akwụ ụgwọ analogues dị ọnụ ala agbakwunyere ụgwọ opekata mpe enwere na ndepụta ọnụahịa nke ndị ahịa ọgwụ nyere
| # | Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|---|
| 1 | Metformin metformin Analogue na ihe mejuputara ma gosiputa ya | 13 nkp | 12 UAH |
| 2 | Reduxin Met metformin, sibutramine Analogue na ihe mejuputara ma gosiputa ya | 20 nkp | -- |
| 3 | Ngwakọta Siofor na ngosipụta analog | 208 rub | 27 UAH |
| 4 | Ọrịa metformin Analogue na ihe mejuputara ma gosiputa ya | 12 nkp | 15 UAH |
| 5 | Analog Mpempe na Akwukwo | 37 nkp | -- |
Nyere ndepụta ọgwụ analogues dabere na ndekọ ọnụ ọgụgụ nke ọgwụ a kacha chọọ
Analogs na ihe mejupụtara ma gosipụta maka ojiji
| Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 nkp | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metinin, Sibutramine | 20 nkp | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 nkp | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Mpempe usoro metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Formethine | 37 nkp | -- |
| Metformin Canon metformin, ovidone K 90, stachi ọka, crospovidone, magnesium stearate, talc | 26 nkp | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
N'elu ndepụta ọgwụ analogues, nke Metformin-Teva Substitutes, bụ nke kachasị mma n'ihi na ha nwere otu ihe mejupụtara nke ihe ndị na-arụ ọrụ ma na-emekọ ihe dabere na ngosipụta maka ojiji
Ngwakọta dị iche iche, nwere ike yikọ ọnụ na njiri na usoro nke ngwa
| Aha | Ọnụahịa na Russia | Ọnụahịa na Ukraine |
|---|---|---|
| Rosiglitazone enyere aka, metformin hydrochloride | -- | -- |
| Glibenclamide Glibenclamide | 30 nkp | 7 UAH |
| Maninyl Glibenclamide | 54 nkp | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 nkp | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeton MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 nkp | 57 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 nkp | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Ọlta | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Glim | -- | -- |
| Glimepiride glimepiride | 27 nkp | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 ite | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Diamlaid glamepiride | 2 ite | -- |
| Micronized Amaryl M Limepiride, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 nkp | 101 UAH |
| Glucovans glibenclamide, metformin | 34 nkp | 8 UAH |
| Dianorm-m Gliclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 nkp | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 nkp | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 nkp | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Mee metformin XR mechie, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 ite | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 nkp | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 nkp | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 nkp | 895 UAH |
| Onglisa saxagliptin | 1472 nkp | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 nkp | 1250 UAH |
| Trazhenta linagliptin | 89 nkp | 1434 UAH |
| Lixumia lixisenatide | -- | 2498 UAH |
| Guarem Guar resin | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 nkp | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 ite | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 nkp | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 nkp | 3200 UAH |
| Invocana canagliflozin | 13 nkp | 3200 UAH |
| Jardins Empagliflozin | 222 nkp | 566 UAH |
| Dulaglutide Trulicity | 115 nkp | -- |
Etu esi achọta analog dị ọnụ ala nke ọgwụ na-akwụ ụgwọ?
Iji chọta analog na-enweghị ego ọfụma n’egwuregwu, mkpụrụ ọgụgụ ma ọ bụ ntụgharị, nke mbụ anyị na-atụ aro ị attentiona ntị na ihe mejupụtara ahụ, ya bụ otu ihe ahụ na njiri mara maka ojiji. Otu ihe eji eme ọgwụ eme ihe ga-egosi na ọgwụ ahụ kwekọrọ na ọgwụ ahụ, ọgwụ kwekọrọ ma ọ bụ ọgwụ ọzọ. Agbanyeghị, echefula maka ihe ndị na - adịghị ike nke ọgwụ ndị yiri ya, nke nwere ike imetụta nchekwa na ịdị irè. Echefula banyere ntuziaka nke ndị dọkịta, ọgwụ ịchọrọ onwe gị nwere ike imerụ ahụ ike gị, yabụ gbaa dọkịta gị mgbe niile tupu ị usingụ ọgwụ ọ bụla.
Ntụziaka Metformin-Teva
Omume ọgwụ
Metformin na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose site na eriri afọ, na - eme ka glucose na - emegagharị, ma na - emekwa ka ọ nwee mmetụta nke anụ ahụ na insulin. Ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ beta nke pancreas, anaghị akpata mmeghachi omume hypoglycemic. Na-ebelata ọkwa nke triglycerides na obere linoproteins dị ala n'ime ọbara. Na-eme ka ahụ gị dị ike ma ọ bụ belata ya. O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.
Mlọ ọgwụ
Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na ngọngọ nri. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ 50-60%. Cmax na plasma ọbara ruru ihe ruru elekere 2.5 mgbe mmịnye ahụ gasị. Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọta na gland salvary, akwara, imeju na akụrụ. Ọ bụ akụrụ na-agbanweghi agbanwe. T1 / 2 bụ awa 9-12. Na arụ ọrụ ezumike n’akuku ezighi ezi, nchịkọta ọgwụ ga-ekwe omume.
Ihe na-egosi
- ụdị ọrịa shuga mellitus nke 2 na-enweghị ọchịchọ nke ketoacidosis (karịsịa na ndị ọrịa na-ebu oke ibu) na arụmọrụ nke usoro ọgwụgwọ nri,
- yana insulin - maka ụdị ọrịa shuga 2 nke ọrịa mellitus, ọkachasị na oke ibu, ya na insulin nke abụọ.
Usoro usoro onunu ogwu
Ọ bụ dibia a ka edobere ọgwụ a n’otu, dabere n’ọkwa glucose dị n’ọbara.
Ọgwụ nke mbụ bụ 500-1000 mg / ụbọchị (mbadamba 1-2). Mgbe ụbọchị 10-15 gachara, mmụba ọzọ na-abawanye ụba n'oge enwere ike dabere na ọkwa glucose ọbara.
Ọgwụ nchekwa ọgwụ na-abụkarị 1500-2000 mg / ụbọchị. (Taabụ 3-4.) Ogo kachasị bụ 3000 mg / ụbọchị (mbadamba 6).
N'ime ndị ọrịa agadi, ọgwụ a na-atụ aro kwa ụbọchị ekwesịghị gafere 1 g (2 mbadamba).
Ekwesịrị iji mbadamba Metọdin were obere mmiri mmiri (iko mmiri) zuru oke ma ọ bụ ozugbo nri ahụ gasịrị. Iji belata nsonaazụ si eriri afọ, a ga-ekewa ihe ị na-eme kwa ụbọchị n'ime usoro 2-3.
N'ihi ịba ụba nke lactic acidosis, a ga-ebelata dose ahụ na nsogbu metabolic siri ike.
Mmetụta akụkụ
Site na nri digestive: ọgbụgbọ, vomiting, dara ụtọ ọnụ, enweghị agụụ, afọ ọsịsa, flatulence, mgbu afọ. Mgbaàmà ndị a bụ ihe a na-ahụkarị na mmalite ọgwụgwọ ma na-apụkarị n'onwe ha. Ihe mgbaàmà ndị a nwere ike belata nhọpụta nke anthocides, ihe dị iche iche nke atropine ma ọ bụ ọgwụ antispasmodics.
Site n'akụkụ nke metabolism: n'ọnọdụ ndị dị ụkọ - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ), yana ọgwụgwọ ogologo oge - hypovitaminosis B12 (malabsorption).
Site na akwara hemopoietic: n'ụzọ ụfọdụ - megaloblastic anaemia.
Site na usoro endocrine: hypoglycemia.
Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ.
Ihe ngbanwe
- mamịrị ketoacidosis, ọrịa mamịrị, prema, shuga,
- arụ ọrụ ezughi oke ọrụ,
- ọrịa siri ike nke nwere nsogbu ịrịa ọrịa akwara: akpịrị ịkpọ nkụ (na ọnya afọ, ọgbụgbọ), ahụ ọkụ, ọrịa na-efe efe, hypoxia (ujo, sepsis, akụrụ, ọrịa akụrụ, ọrịa bronchopulmonary)
- ngosipụta a na - akpọ clinically nke ọrịa siri ike na nke na - adịghị ala ala nke nwere ike ibute mmepe nke hypoxia anụ ahụ (obi ma ọ bụ akụkụ iku ume, nnukwu myocardial infarction),
- ezigbo arụ ọrụ ịwa ahụ na mmerụ ahụ (mgbe egosiri ọgwụ insulin),
- arụ ọrụ imeju.
egbu egbu egbu, ị alcoholụ mmanya na-egbu egbu,
- iji maka opekata mpe, ma ọ dịkarịa ala ụbọchị abụọ tupu yana n'ime ụbọchi abụọ ka emechara nyocha redio ma ọ bụ x-ray na ntinye nke ayodiin nwere ọdịiche,
- lactic acidosis (gụnyere akụkọ ihe mere eme),
- esoro na nri kalori (erughi 1000 cal / day),
- afọ ime
- oge ọmụmụ,
- Hypersensitivity na ọgwụ.
A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.
Ime na lactation
Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n’oge ime n’oge ị na-ewere Metformin, ekwesịrị ịkagbu ya, ekwenyekwa ọgwụ insulin. Ebe o bu na enweghi data banyere banye n’ime mmiri ara, a na - enye ogwu a n’ime mmiri ara. Ọ bụrụ na ọ dị mkpa iji Metformip n’oge ara, a ga-akwụsị ịhapụ inye ya ara.
Ntụziaka pụrụ iche
N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ akụrụngwa. Ọbụlagodi ugboro 2 n’afọ, yana n’ile anya myalgia, ekwesịrị ịhapụ lactate dị na plasma. Na mgbakwunye, otu ugboro n’ime ọnwa isii ọ bụla, ọ dị mkpa ịchịkwa ọkwa nke creatinine na ọbara ọgbụgba (ọkachasị n’etiti ndị ọrịa agadi.) Ekwesighi inye usoro Metformin ọgwụ ma ọ bụrụ na ọkwa creatinine dị n’ọbara dị elu karịa 135 μmol / L n’ime ụmụ nwoke na 110 μmol / L.
Ikekwe ojiji nke ọgwụ Metformin yana njikọta usoro sulfonylurea. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.
Nkeji iri anọ na asatọ tupu ma ọ bụ n’ime elekere iri anọ na asatọ gbasara rediopaque (urography, iv angiography), ị kwesịrị ịkwụsị ị were Metformin.
Ọ bụrụ na onye ọrịa ahụ na-arịa ọrịa bronchopulmonary ma ọ bụ ọrịa na-efe efe nke akụkụ ahụ akụkụ, ekwesịrị ịgwa dọkịta na-aga ya ozugbo.
N'oge ọgwụgwọ, ị kwesịrị ịhapụ ị alcoholụ mmanya na ọgwụ nwere ethanol. .
Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa
Ojiji iji ọgwụ ahụ monotherapy anaghị emetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ.
Mgbe agbakwunyere Metformin na ndị ọzọ hypoglycemic (ihe dị n'ụkpụrụ sulfonylurea, insulin), ọnọdụ hypoglycemic nwere ike ịmalite ebe ike ịkwọ ụgbọala na itinye aka na ọrụ ndị ọzọ dị ize ndụ chọrọ nlebara anya na mmeghachi omume psychomotor ngwa ngwa.
Dodoụbiga ya ókè
Site na mmachi nke Metformin, a acid acidisis nwere nsonaazụ na-egbu egbu ga-ekwe omume. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ.
Ihe mgbaàmà nke lactic acidosis: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, okpomoku ahụ dị ala, mgbu afọ, olu mgbu, n'ọdịniihu enwere ike ịba ụba iku ume, ọgbụgbọ, nsụda mmụọ na mmepe nke coma.
Ọgwụgwọ : n'ihe banyere ihe ịrịba ama nke lactic acidosis, a ga-akwụsị ọgwụgwọ na Metformin ozugbo, onye ọrịa kwesịrị ịga ụlọ ọgwụ ngwa ngwa, ebe o kpebisiri ike itinye uche nke lactate, gosipụta nchoputa ahụ. Measurezọ kachasị dị irè maka iwepu lactate na metformin n'ahụ ahụ bụ hemodialysis. A na-eme ọgwụgwọ Symptomatic.
Site na usoro ọgwụgwọ ejikọtara na Metformin na sulfonylureas, hypoglycemia nwere ike ịmalite.
Mkparịta ụka ọgwụ ọjọọ
Ekwesighi ka eji Danazol eme ihe oge a iji zere uto hyperglycemic nke ikpeazu. Ọ bụrụ na ọgwụgwọ na danazol dị mkpa ma kwụsịchaa nke ikpeazụ, a chọrọ ndozi nke metformin na ayodiin iji chịkwaa ọkwa nke glycemia.
Njikọ ndị chọrọ nlekọta pụrụ iche: chlorpromazine - mgbe ewere ya na nnukwu doses (100 mg / ụbọchị) na-abawanye glycemia, na-ebelata ntọhapụ nke insulin.
Na ọgwụgwọ nke ọgwụ mgbochi na mgbe ịkwụsịsịrị ịhapụ nke ikpeazụ, achọrọ ịgbatị dose nke metformin n'okpuru njikwa glycemia.
Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, AC inhibitors, clofibrateeri, cyclophosphamide, β-blockers, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.
Site na iji GCS eme ihe n'otu oge, mgbochi ogwu a na-aralụ a ,ụ, epinephrine, sympathomimetics, glucagon, homonụ thyroid, thiazide na loop diuretics, ọgwụ phenothiazine, usoro nicotinic acid, mbelata mmetụta hypoglycemic nke metformin ga - ekwe omume.
Cimetidine belatara mkpochapu nke metformin, nke na-abawanye ohere nke lactic acidosis.
Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin).
Mmanya na-aba n'anya na-eme ka ohere mmadụ nwere ịrịa lactic acidosis n’oge ị alcoholụbiga mmanya ókè, karịchaa n’ihe metụtara ibu ọnụ ma ọ bụ ịgbaso nri kalori, yana ọrịa imeju.
Usoro ahịa ọgwụ ahịa
Ogwu gi bu ogwu.
Usoro na ọnọdụ nchekwa
Chekwaa n’ebe kpọrọ nkụ, ọchịchịrị na okpomọkụ nke 15 Celsius ruo 25 Celsius.
Ekwela ka ụmụaka ghara iru ya.
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