Atomax (Atomax) - ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Aha mba ofesi - atomax

Ngwakọta na ụdị ntọhapụ

Mbadamba ihe mkpuchi ihe fọrọ nke nta ka ọ bụrụ ọcha, gbaa gburugburu, biconvex, nke nwere ọkwa n'otu akụkụ, a na-anabata ike ịkpa ike. Otu mbadamba 1 nwere atorvastatin (n'ụdị nke calcium trihydrate atorvastatin) 10 mg.

Ndị pụrụ iche: carbonate carbon - 6 mg, lactose - 52.5 mg, ọka ọka - 25.66 mg, croscarmellose sodium - 5.21 mg, povidone (K-30) - 3.5 mg, magnesium stearate - 2 mg, anhydrous colloidal silicon dioxide - 1.5 mg, crospovidone - 4 mg

Ihe mejupụtara Shell: primellose 15 CPS - 2.05 mg, talc dị ọcha - 0.22 mg, titanium dioxide - 0.36 mg, triacetin - 0.16 mg.

10 PC - blisters (3) - ngwugwu nke kaadiboodu.
10 PC - blisters (4) - ngwugwu nke kaadiboodu.
10 PC - blisters (5) - ngwugwu nke kaadiboodu.

Ndị pụrụ iche: carbonate carbon - 10 mg, lactose - 78.34 mg, ọka ọka - 40 mg, croscarmellose sodium - 10.47 mg, povidone (K-30) - 5 mg, magnesium stearate - 4 mg, anhydrous colloidal silicon dioxide - 3 mg, crospovidone - 7 mg

Ihe mejupụtara Shell: primellose 15 CPS - 3.3 mg, talc dị ọcha - 0.36 mg, titanium dioxide - 0,58 mg, triacetin - 0.26 mg.

10 PC - blisters (3) - ngwugwu nke kaadiboodu.
10 PC - blisters (4) - ngwugwu nke kaadiboodu.
10 PC - blisters (5) - ngwugwu nke kaadiboodu.

Linlọ ọgwụ na ọgwụ ọgwụ

Ndị na-ere ọgwụ

Onye na-ahụ maka mmachi ahụ bụ HMG-CoA reductase inhibitor.

Ogwu ogwu nke Atomax

Hypolipidem gị n'ụlọnga si ìgwè nke statins. Ihe nchoputa ihe ndozi nke HMG-CoA reductase, enzyme nke na - agbanwe ato nke 3-hydroxy-3-methylglutaryl coenzyme A mevalonic acid, ihe eji eme ka sterols, tinyere cholesterol. A na-etinye TG na cholesterol n'ime imeju na VLDL, banye na plasma ma bufee ya na akwara anụ ahụ.

Emebere LDL site na VLDL n'oge mmekorita ya na ndị na-anabata LDL. Ọ na-ebelata ịdị n'otu nke cholesterol na lipoproteins na plasma n'ihi mgbochi nke HMG-CoA reductase, njikọ nke cholesterol na imeju na mmụba nke ọnụ ọgụgụ ndị na-anabata LDL na sel elu, nke na-eduga n'ịba ụba na catabolism nke LDL.

Na-ebelata nguzobe nke LDL, na - eme ka mmụba na nkwụsi ike na ọrụ nke ndị na - anabata LDL. Mbelata mkpokọta LDL na ndị ọrịa nwere hypercholesterolemia homozygous familial, nke na-anaghị anabata ọgwụgwọ na ọgwụ mmachi.

Na-ebelata mkpokọta cholesterol site na 30-46%, LDL - site na 41-61%, apolipoprotein B - site na 34-50% na TG - site na 14-33%, na-eme ka mmụba nke cholesterol HDL na apolipoprotein A. Dose-dependence belata mkpokọta nke LDL na ndị ọrịa nwere ụdị hypercholesterolemia homozygous na-eguzogide ọgwụ na ọgwụ hypolipPs ndị ọzọ.

N'ụzọ dị oke mkpa belata ihe egwu nke nsogbu nsogbu ischemic (gụnyere mmepe nke ọnwụ site na infarction myocardial) site na 16%, ihe ize ndụ nke ịmaliteghachi ụlọ ọgwụ maka angina pectoris, yana ihe ịrịba ama nke ischemia myocardial, na 26%. O nweghi uto carcinogenic na mutagenic. A na-enweta ọgwụ ọgwụgwọ ahụ izu abụọ mgbe ebidochara usoro ọgwụgwọ, rute karịa mgbe izu anọ gachara ma dịgide na oge ọgwụgwọ niile.

Mlọ ọgwụ

Idopu ihe n’ulo di elu. Oge iru C_max - 1-2 awa, C_max ihe na-arụ ọrụ na plasma ọbara dị na ụmụ nwanyị dị elu karịa 20%, AUC dị ala site na 10%, Cmax na ndị ọrịa nwere ọrịa cirrhosis na-egbu egbu bụ ugboro iri na isii, AUC ji okpukpu iri na otu dị elu karịa nke nkịtị. Nri jiri nwayọ belata ngwa-ngwa na oge iwere ọgwụ (site na 25% na 9%, otu), mana mbelata nke LDL cholesterol yiri nke ahụ na iji atorvastatin na-enweghị nri.

Ntinye uche nke atorvastatin mgbe etinyere ya na mgbede dị ala karịa n'ụtụtụ (ihe dịka 30%). E gosipụtara mmekọrịta kwụụrụ n’etiti ogosi nke itinye uche na ogo nke ọgwụ ahụ. Bioavailability - 14%, bioavailability usoro nke ọrụ mgbochi na-egbochi HMG-CoA reductase - 30%.

Usoro bioavailability dị ala bụ n'ihi metabolism metabolism na akpụkpọ anụ mucous nke eriri afọ (GIT) yana n'oge "ụzọ mbụ" site na umeji. Nkezi Vd bụ 381 L, njikọta na protein ndị na-edozi plasma karịrị 98%. Ọ metabolized tumadi na imeju n'okpuru ọrụ nke isoenzymes CYP3A4, CYP3A5 na CYP3A7 na-etolite ọgwụ metabolites na-arụsi ọrụ ike (ortho na ngwongwo parahydroxylated, ngwaahịa nke oxidation beta).

Na vitro, ortho- na para-hydroxylated metabolites nwere mmetụta inhibitory na GMK-CoA reductase, dị ka nke atorvastatin. Mmetụta inhibitory ọgwụ a na-emegide HMG-CoA reductase bụ ihe dịka 70% kpebisiri ike site na ọrụ nke ịmegharị metabolites na-adịgide ruo ihe dị ka awa 20-30 n'ihi ọnụnọ ha. Ndi_1/2 - elekere 14. Akpachapụ ya na bile mgbe hepatic na / ma ọ bụ extrahepatic metabolism (ọ dịghị eme ngbanwe ahụ enterohepatic). Ihe na-erughị 2% nke ọgwụ a na-ekpebi n’ime mmamịrị.

Achọghị ya ka ọ dịrị n'oge ịba ọcha n'anya n'ihi njikọkọ nke ukwuu na protin plasma.

Site na nkwarụ imeju na ndị ọrịa nwere ị cirụ mmanya na-egbu egbu (-mụ-Pyug B), Cmax na AUC mụbara nke ukwuu (oge 16 na 11, n'otu n'otu).

C_max na AUC nke ọgwụ na ndị agadi (65 afọ okenye) bụ 40 na 30%, n'otu aka ahụ, dị elu karịa ndị nọ na ọrịa ndị okenye na-eto eto (enweghị uru ọria). Cmax n'ime ụmụ nwanyị dị 20% dị elu, na AUC bụ 10% dị ala karịa ụmụ nwoke (ọ nweghị uru ụlọ ọgwụ).

Ọkpụkpụ ntaramahụ ahụ anaghị emetụta nsị plasma nke ọgwụ.

- na nri iji gwọọ ndị ọrịa nwere ọrịa TG (ụdị nke IV dịka Fredrickson) yana ndị ọrịa nwere dysbetalipoproteinemia (ụdị III dịka Fredrickson), ebe ọgwụgwọ nri anaghị enye mmetụta zuru oke,

- na mgbakwunye na nri iji belata ọkwa dị elu nke ngụkọta cholesterol, LDL-C, apolipoprotein B na TG ma na-abawanye HDL-C na ndị ọrịa nwere hypercholesterolemia bụ isi, heterozygous ezinụlọ na hypercholesterolemia na-enweghị ezinụlọ (jikọtara ọnụ) hyperlipidemia (ụdị IIa na IIb IIb IIb ),

- iji belata ogo nke cholesterol zuru oke na LDL-C n’ime ndị ọrịa nwere hypercholesterolemia homozygous familial, mgbe ọgwụgwọ nri na ụzọ ọgwụgwọ ndị ọzọ anaghị agwọ ọrịa anaghị arụ ọrụ nke ọma.

Usoro usoro onunu ogwu

Tupu nhọpụta Atomax, onye ọrịa ahụ kwesịrị ịkwado maka inye nri azụ dị ala, nke ọ ga-enwerịrị ileru anya na oge ọgwụgwọ niile.

Usoro ọgwụgwọ mbụ bụ nkezi 10 mg 1 oge / ụbọchị. Ọgwụ dịgasị iche site na 10 ruo 80 mg 1 oge / ụbọchị. Enwere ike iji ọgwụ a mee ihe n'oge ọ bụla n'ụbọchị ma ọ bụ n'agbanyeghị oge nri. A họrọ ọgwụ ahụ na-eburu n'uche usoro mbụ nke LDL-C, ebumnuche ọgwụgwọ na mmetụta nke onye ọ bụla. Na mmalite ọgwụgwọ na / ma ọ bụ n'oge mmụba nke dose nke Atomax, ọ dị mkpa iji nyochaa ọkwa nke plasma lipid kwa izu 2-4 ma dozie dose ahụ dabere.

Na hypercholesterolemia bụ isi na hyperlipidemia agwakọta n'ọtụtụ oge, nhọpụta nke Atomax na dose 10 mg 1 oge / ụbọchị zuru ezu. A na-ahụkarị ọgwụgwọ ọgwụgwọ dị ukwuu ka izu abụọ gachara, dịka iwu, a na-ahụkarịkarị ọgwụgwọ ọgwụgwọ ka izu anọ gachara. Site n'ọgwụgwọ ruo ogologo oge, mmetụta a na-adịgide.

Iji ogwu eme ihe n’ime ndị ọrịa nwere ọdịda akụrụ na ọrịa akụrụ adịghị emetụta ọkwa nke atorvastatin na plasma ọbara ma ọ bụ ogo nke mbelata ọdịnaya nke LDL-C mgbe ejiri ya, ya mere, achọrọ ịgbanwe ọgwụ a chọrọ.

Mgbe ị na-eji ọgwụ eme ihe na ndị ọrịa agadi enweghị ọdịiche na nchekwa, nrụpụta ọrụ, ma ọ bụ ihe mgbaru ọsọ nke mgbaru ọsọ ọgwụgwọ Lipid na-emetụta ma ọha mmadụ.

Mmetụta akụkụ Atomax

Si uche: amblyopia, ịnụ ntị na ntị, akpọnwụ nke conjunctiva, nsogbu nke ebe obibi, ọbara ọgbụgba na anya, ntị chiri, mgbali intraocular, parosmia, uto nke uto, ọnwụ nke ihe ụtọ.

Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: isi ọwụwa, dizziness, asthenic syndrome, nsogbu ehighị ụra ma ọ bụ ụra, ụra abalị, amnesia, paresthesias, neuropathy akụkụ, akuko obi, ataxia, hyperkinesis, ịda mba, hypesthesia.

Site na nri digestive: ọgbụgbọ, obi mgbawa, afọ ntachi ma ọ bụ afọ ọsịsa, flatulence, gastralgia, mgbu nke afọ, anorexia ma ọ bụ agụụ riri nri, ọnụ na-egbu egbu, belicia, dysphagia, vomiting, stomatitis, esophagitis, glossitis, gastroenteritis, hepatitis, hepatic colic, cheilitis, ọnya afọ. pancreatitis, cholestatic jaundice, ụba ọrụ nke enzymes imeju (AST, ALT), ọbara ọgbụgba, melena, goms ọbara ọgbụgba, tenesmus.

Site na usoro mọzụlụ: ọrịa ogbu na nkwonkwo, nkwonkwo akwara ụkwụ, bursitis, myositis, myopathy, ọrịa ogbu na nkwonkwo, myalgia, rhabdomyolysis, nkwonkwo nkwonkwo, azụ mgbu, ụbara CPK.

Site na usoro iku ume: ọla kọpa, rhinitis, dyspnea, ụkwara ume ọkụ bronchi, imi.

Site na usoro urinary: ọrịa urogenital, ọrịa akụkụ, dysuria (gụnyere pollakiuria, nocturia, urinary incontinence ma ọ bụ njigide urinary, urination dị mkpa), nephritis, cystitis, hematuria, urolithiasis, albuminuria.

Site na usoro omumu: ọbara ọgbụgba, ọbara ọgbụgba, metrorrhagia, epididymitis, mbelata libido, enweghi ike, ejaculation, gynecomastia.

Mmeghachi omume akpụkpọ anụ: alopecia, sweating, eczema, seborrhea, ecchymosis.

Si usoro obi: mgbu obi, palpitations, vasodilation, hyperension orthostatic, phlebitis, arrhythmia.

Site na sistemụ hemopoietic: anaemia, lymphadenopathy, thrombocytopenia.

Site n'akụkụ nke metabolism: hyperglycemia, hypoglycemia, ibu ibu, njọ nke N'ezie nke gout, ahụ ọkụ.

Mmeghachi omume nfụkasị ahụ: pruritus, ọnya anụ ahụ, kọntaktị dermatitis, urticaria, angioedema, facial edema, photoensitivity, anaphylaxis, erythema multiforme exudative (gụnyere ọrịa Stevens-Johnson syndrome), na - egbu egbu epidermal necrolysis (ọrịa Lyell syndrome).

Ihe ngbanwe Atomax

- gbara afọ 18 (agbadobeghị ịdị irè na nchekwa),

- ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba na ọrụ nke serum transaminases (karịa ugboro atọ ma e jiri ya tụnyere VGN) nke sitere na mmalite amabeghị

- Hypersensitivity na mmiri nke ọgwụ.

Na ịkpachara anya nke a inụrụma na-egbu egbu, yana akụkọ banyere ọrịa imeju, imirikiti nnukwu electrolyte, ọrịa endocrine na metabolic, hypotension, nnukwu ọrịa (sepsis), ọrịa na-achịkwaghị achịkwa, nnukwu ịwa ahụ, mmerụ ahụ, ọrịa akwara nke akwara.

Ime na lactation

Atomax bụ contraindicated na ime na lactation (inye ara).

Amabeghị ma atorvastatin na-apụ apụ na mmiri ara. N’enye ohere nke ihe ojoo n’ime ụmụ aka, ọ bụrụ na ọ dị mkpa, iji ọgwụ n’oge a na-enye nwa ga-ekpebi nkwụsị nke ị breastụ ara.

Mụ nwanyị nwere afọ ọmụmụ n'oge ịgwọ ọrịa kwesịrị iji ụzọ mgbochi afọ ime. Enwere ike ịgwa Atorvastatin ụmụ nwanyị toro afọ ịmụ nwa naanị ma ọ bụrụ na ịmụ nwa ga-adị obere, a na-emekwa ka onye ọrịa mara ihe ọghọm dị na ọgwụgwọ nke nwa ebu n’afọ.

Jiri maka ọrụ imeju na-arụ ọrụ

Ọ contraindicated bụrụ na nke ọrịa imeju na-arụ ọrụ ma ọ bụ na-abawanye na ọrụ nke transumases ọbara (karịa ugboro atọ ma e jiri ya tụnyere VGN) nke sitere na mmalite amabeghị. Eji ya na akpachapụ anya na-egbu egbu a ,ụrụma, na akụkọ ihe mere eme nke ọrịa imeju.

Jiri maka ọrụ ezighi ezi na-arụ ọrụ

Ọrịa akụrụ anaghị emetụta nsonaazụ nke atorvastatin na plasma ọbara ma ọ bụ mmetụta ọ nwere na metabolism lipid. N'akụkụ nke a, a chọghị ịgbanwe ọgwụ na ndị ọrịa nwere ọrụ mgbazinye nsogbu. Ọ bụ ezie na emebeghị ọmụmụ banyere ndị ọrịa nwere ọrịa akụrụ, hemodialysis bụ eleghi anya na ọ ga - eme ka ngbanwe nke atorvastatin dị elu, ebe ọ na - ejikọ protein protein.

Ojiji nke ogwu n’ime umuaka

Ndi nwere mgbochi: afọ rue afọ 18 (edozighi ịdị irè na nchekwa).

Jiri ndị ọrịa agadi

Ntụziaka pụrụ iche maka nnabata

Tupu ịmalite Atomax, a ga-enye onye ọrịa iwu usoro hypocholesterol kwesịrị, nke ọ ga-agbaso n'oge usoro ọgwụgwọ niile.

Ojiji nke HMG-CoA reductase inhibitors iji belata egbugbere ọnụ ọbara nwere ike iduga mgbanwe na usoro biochemical na-egosipụta ọrụ imeju.

Ekwesịrị ilebara ọrụ imeju anya tupu ịmalite usoro ọgwụgwọ, izu isii na iri na abụọ mgbe mmalite nke ọchịchị Atomax yana mgbe ọ bụla na-abawanye, na kwa oge, dịka ọmụmaatụ, ọnwa 6 ọ bụla. Enwere ike ịhụ mmụba na ọrụ nke enzymes hepatic n'ime ọbara ọbara n'oge ọgwụgwọ Atomax. Ekwesịrị inyocha ndị ọrịa nwere mmụba na ọrụ transaminase ruo mgbe ọkwa enzyme ga-alaghachi na nkịtị. N'ọnọdụ nke ụkpụrụ ALT ma ọ bụ AST karịrị VGN ugboro atọ karịa VGN, a na-atụ aro ka ibelata ọgwụ Atomax ma ọ bụ kwụsị ọgwụgwọ.

Ekwesịrị iji Atomax kpachara anya na ndị ọrịa na-a abuseụbiga mmanya ókè na / ma ọ bụ nwee ọrịa imeju, ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba na-aga n'ihu na ọrụ transaminase nke na-amaghị ama sitere na ọgwụ ahụ.

Ọrịa Atorvastatin nwere ike ime ka myopathy. Nyocha nke myopathy (mgbu mgbu na adịghị ike na mgbakwunye na mmụba na ọrụ CPK site na ugboro 10 ma e jiri ya tụnyere VGN) kwesịrị iburu n'uche ndị ọrịa nwere ọrịa myalgia, mmerụ ahụ ma ọ bụ adịghị ike na / ma ọ bụ mmụba dị ịrịba ama na ọrụ CPK. E kwesịrị ịdọ ndị ọrịa ọdụ na ha kwesịrị ịgwa dọkịta ozugbo ozugbo banyere ọdịdị mgbu na-enweghị ike ma ọ bụ adịghị ike na akwara, ma ọ bụrụ na ha na-arịa ọrịa ịba ma ọ bụ ahụ ọkụ. A ga-akwụsị ịgwọ ọrịa Atomax ma ọ bụrụ na enwee mmụba dị ukwuu na ọrụ CPK ma ọ bụ ọnụnọ nke myopathy nke enwetara ma ọ bụ enyo enyo. Ihe ọghọm nke myopathy na ọgwụgwọ nke ọgwụ ndị ọzọ nke klas a mụbara site na oge nke cyclosporine, fibrates, erythromycin, niacin ma ọ bụ ọgwụ azole antifungal. Ọtụtụ n'ime ọgwụ ndị a na-egbochi metabolism nke CYP3A4 na usoro mgbasa ozi na / ma ọ bụ ụgbọ njem ọgwụ. Atorvastatin bụ nke sitere na CYP3A4.Mgbe ị na-edepụta atorvastatin yana ọgwụ fibrates, erythromycin, ọgwụ immunosuppressive, ọgwụ azole antifungal ma ọ bụ niacin na usoro onunu ogwu, a ga-elele uru na ọghọm nke ọgwụgwọ kwesịrị ka ejiri nlezianya chọpụta ndị ọrịa oge niile ịchọpụta mgbu akwara ma ọ bụ adịghị ike, karịchaa n'ọnwa ndị mbụ nke ọgwụgwọ yana oge nke ịba ụba doses ọ bụla ọgwụ. N'ọnọdụ ndị dị otú ahụ, enwere ike ịkwado mkpebi nke oge ọrụ KFK, ọ bụ ezie na njikwa dị otú ahụ anaghị egbochi mmepe nke myopathy siri ike.

Mgbe ị na-eji atorvastatin, yana ọgwụ ndị ọzọ nke klas a, a na-akọwapụta ikpe nke rhabdomyolysis na nnukwu akwara ọdịda n'ihi myoglobinuria. Atomax kwesịrị ka a kwụsịtụrụ nwa oge ma ọ bụ kwụsịchaa kpamkpam ma ọ bụrụ na e nwere ihe ịrịba ama nke myopathy enwere ike ma ọ bụ ihe dị ize ndụ maka mmepe nke ọdịda akwara n'ihi rhabdomyolysis (dịka ọmụmaatụ, nnukwu ọrịa na-efe efe, hypotension, ịwa ahụ siri ike, trauma, metabolic siri ike, endocrine na nsogbu ọgba aghara na enweghị nsogbu).

Tupu ịmalite ọgwụgwọ Atomax, ọ dị mkpa ịnwale iji nweta hypercholesterolemia site na usoro nri nri zuru oke, ịba ụba ọrụ mmega ahụ, oke ibu na ndị ọrịa nwere oke ibu na ọgwụgwọ nke ọnọdụ ndị ọzọ.

E kwesịrị ịdọ ndị ọrịa ọdụ na ha kwesịrị ịgakwuru dọkịta ozugbo ma ọ bụrụ na mgbu na-enweghị nkọwa ma ọ bụ adịghị ike nwere ahụ, ọ bụrụ na ọnya ma ọ bụ ahụ ọkụ na-eso ya.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Achọghị mmetụta ọjọọ nke Atomax n'ikike ịnya ụgbọ ala na iji usoro rụọ ọrụ akọghị.

Dodoụbiga ya ókè

Ọgwụgwọ: ọ nweghị ọgwụ mgbochi akọwapụtara, ana-agwọ ọrịa ọgwụgwọ. Ọkpụkpụ anụ ahụ adịghị arụ ọrụ.

Mmekọrịta na ọgwụ ndị ọzọ

Ihe ọghọm nke myopathy n'oge ọgwụgwọ nke ọgwụ ndị ọzọ nke klas a na-abawanye site na ojiji nke cyclosporine, fibrates, erythromycin, ndị ọrụ antifungal metụtara azoles, na niacin.

Site na ntinye nke oge atorvastatin na nkwụsị nke nwere magnesium na aluminom hydroxides, ntinye nke atorvastatin na plasma belatara ihe dịka 35%, agbanyeghị, ogo mbelata ogo LDL-C agbanweghị.

Iji otu oge atorvastatin anaghị emetụta ọgwụ ọgwụ nke antipyrine, yabụ, mmekọrịta na ọgwụ ndị ọzọ metabolized site na otu cytochrome isoenzymes anaghị atụ anya.

Site na iji colestipol na-emekọ ihe ọnụ, plasma nke atorvastatin belatara ihe dị ka 25%. Agbanyeghị, mmetụta dị ala nke njikọta nke atorvastatin na colestipol karịrị nke ọgwụ ọ bụla n’otu n’otu.

Site na nchịkwa nke digoxin na atorvastatin ugboro ugboro na 10 mg, ikike itinye digoxin na plasma ọbara agbanweghị. Ka osi di, mgbe eji digoxin na atorvastatin na onwa 80 mg / ubochi, ntughari nke digoxin riri elu dika 20%. Ekwesịrị ị hụ ndị ọrịa na-anata digoxin yana atorvastatin.

Iji otu oge atorvastatin na erythromycin (500 mg 4 ugboro / ụbọchị) ma ọ bụ clarithromycin (500 mg 2 ugboro / ụbọchị), nke na-egbochi CYP3A4, mmụba na plasma nwere mkpokọta nke atorvastatin.

N'iji oge nke atorvastatin (10 mg 1 oge / ụbọchị) na azithromycin (500 mg 1 oge / ụbọchị), itinye uche nke atorvastatin na plasma ọbara agbanweghị.

Atorvastatin enweghị mmetụta ọfụma na ụlọ ọrụ gbasara mkpokọta nke terfenadine na plasma ọbara, nke CYP3A4 metabolized ka ukwuu; n'akụkụ a, ọ bụ eleghi anya na atorvastatin nwere ike imetụta parameters nke ọgwụ ndị ọzọ CYP3A4 ndị ọzọ.

Site n'iji atorvastatin na oge onyunyo ogwu nke nwere norethindrone na ethinyl estradiol, ọnụọgụ AUC nke northindrone na ethinyl estradiol hụrụ ihe dịka 30% na 20%, n'otu n'otu. E kwesịrị ịtụle mmetụta a mgbe ị na-ahọrọ ọgwụ mgbochi nwanyị maka nwanyị na-anata atorvastatin.

Enweghị mmekọrịta dị egwu dị n'etiti atorvastatin na estrogens hụrụ.

Mgbe ị na-amụ mmekọrịta nke atorvastatin na warfarin na cimetidine, enweghị mmekọrịta dị oke egwu a hụrụ.

Site n’otu oge eji atorvastatin na dose nke 80 mg na amlodipine na dose nke 10 mg, ọgwụ ọgwụ nke atorvastatin na steeti oruru agbanwe agbanwebeghị.

Ihe eji emeju atorvastatin nwere ihe mgbochi nchebe nke a maara dị ka ndị na - egbochi CYP3A4 tinyere mmụba nke mkpokọta plasma nke atorvastatin.

Onwebeghi mmetụta ọjọọ dị na ọgwụ ọjọọ nke atorvastatin na ndị na-egbochi ihe ọgụ.

Amaghị ọgwụ ike ọgwụ ọgwụ.

Usoro ahịa ọgwụ ahịa

Ogwu gi bu ogwu.

Usoro na ọnọdụ nchekwa

Ndepụta B. Ekwesịrị ịchekwa ọgwụ ahụ ka ụmụaka ghara iru ya, n'ebe akọrọ, gbara ọchịchịrị na-adịghị elu karịa 25 Celsius. Ndụ shelf bụ afọ 2.

Iji ọgwụ atomax mee ihe naanị dị ka dọkịta nyere iwu, a na-enye nkọwa ahụ maka ntụnye!

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Kedu ihe a na-agaghị emeli mgbe erichara nri, ka ọ ghara imerụ ahụike

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Amaghị nwa (amụghị nwa) - whim ma ọ bụ mkpa?

Ihe ngosi maka ojiji

Ọgwụ Atomax a na-eji ya na nri iji belata ọkwa dị elu nke mkpokọta cholesterol, LDL-C, apolipoprotein B na TG ma na-abawanye HDL-C na ndị ọrịa nwere hypercholesterolemia bụ isi, heterozygous ezinụlọ na hypercholesterolemia na-enweghị ezinụlọ na jikọtara (agwakọta) hyperlipidemia (ụdị IIa na IIb IIb. ), jikọtara ya na nri maka ịgwọ ndị ọrịa nwere ọ̀tụ̀tụ̀ ọbara dị elu nke TG (ụdị nke IV dị ka Fredrickson) yana ndị ọrịa nwere dysbetalipoproteinemia (ụdị III dị ka Fredrickson), na usoro ọgwụgwọ nri anaghị enye mmetụta zuru oke, iji belata Nia ngụkọta cholesterol na LDL-C na ọrịa na homozygous ezinụlọ hypercholesterolemia, mgbe nri ọgwụ na ndị ọzọ na-abụghị pharmacological agwọ ọrịa na-adịghị zuru ezu irè.

Ofzọ nke ngwa

Tupu oge atọrọ Atomax onye ọrịa ahụ ga-akwadokwa usoro iri nri dị ala iji belata, nke ọ ga-agbaso ruo oge ọgwụgwọ niile.
Usoro ọgwụgwọ mbụ bụ nkezi 10 mg 1 oge / ụbọchị. Ọgwụ dịgasị iche site na 10 ruo 80 mg 1 oge / ụbọchị. Enwere ike iji ọgwụ a mee ihe n'oge ọ bụla n'ụbọchị ma ọ bụ n'agbanyeghị oge nri. A họrọ ọgwụ ahụ na-eburu n'uche usoro mbụ nke LDL-C, ebumnuche ọgwụgwọ na mmetụta nke onye ọ bụla. Na mmalite ọgwụgwọ na / ma ọ bụ n'oge mmụba nke dose nke Atomax, ọ dị mkpa iji nyochaa ọkwa nke plasma lipid kwa izu 2-4 ma dozie dose ahụ dabere.
Na hypercholesterolemia bụ isi na hyperlipidemia agwakọta, n'ọtụtụ oge, nhọpụta nke Atomax na dose 10 mg 1 oge / ụbọchị zuru oke. A na-ahụkarị ọgwụgwọ ọgwụgwọ dị ukwuu ka izu abụọ gachara, dịka iwu, a na-ahụkarịkarị ọgwụgwọ ọgwụgwọ ka izu anọ gachara. Site n'ọgwụgwọ ruo ogologo oge, mmetụta a na-adịgide.
Ojiji nke ọgwụ ahụ n’ime ndị ọrịa nwere akụrụ akwara na ọrịa akụrụ anaghị emetụta ọkwa nke atorvastatin na plasma ọbara ma ọ bụ ogo nke mbelata ọdịnaya nke LDL-C n’oge eji ya, ya mere, a chọghị ịgbanwe ọgwụ.
Mgbe ị na-eji ọgwụ ahụ eme ihe na ndị ọrịa merela agadi, enweghị ọdịiche na nchekwa, ịdị irè ma ọ bụ nweta ebumnuche nke usoro ọgwụgwọ iji egbugbere ọnụ na-adịghị ala ma e jiri ya tụnyere ọnụ ọgụgụ mmadụ niile.

Etu esi ewere choromerol na Atomax?

Ọgwụ dị n'ụdị mbadamba nkume. Akụkụ ha bụ convex, elu ya siri ike. N’otu akụkụ enwere ihe ọghọm. Ha nwere shei soluble, bu nke nwere agba di ọcha. Mbadamba mbadamba ahu juru na blisters, nke edochiri n’ime igbe kaadi riri oke.

ihe na-arụ ọrụ (ihe mejupụtara), nke bụ atorvastatin,
ọka ọka
carbon dioxide
lactose
povidone
sodium croscarmellose
sịlịkọn
ikuku na-egbu egbu
crospovidone.

Gịnị bụ shei nke mbadamba ihe? Site na triacetin, talc ọcha, primmeloza, titanium dioxide.

Etu esi a Atụ mmanya Atomax, ntuziaka maka ojiji nke dị na nchịkọta, onye ọ bụla kwesịrị ịma. Nke a bụ ọgwụ na-eme ka ike gwụ ala, bụ nke ebumnuche iji wedata cholesterol, nke na - emetụta ahụ mmadụ. N'akuku ndi otu statins. Ọzọkwa, ọgwụ bụ asọmpi nhọrọ na-egbochi HMG-CoA reductase. Ezubere ya maka ọrụ ọzọ: iwetulata plasma lipoproteins. Atomax nwere mmetụta bara uru na lipoproteins dị ala n'elu mkpụrụ ndụ akwara.

N'ihi ọgwụgwọ ahụ, a na-achọpụta mmụba a kapịrị ọnụ na ọrụ ndị na-anabata ndị LDL. Okwesiri ighota ihe ojoo di ma oria nke ischemia.

Ọgwụ anaghị enwe mmetụta ọjọọ n’ahụ.

Kedu mgbe ichere maka nsonaazụ? Iji hụ mgbanwe dị mma, ịkwesịrị ị were ọgwụ ọbụlagodi izu abụọ. Ekwesịrị iji ọgwụ ahụ otu ọnwa site na mmalite ọgwụgwọ. Mgbe usoro ahụ gwụchara, mmetụta ahụ ga-ahụ ogologo oge.

Ihe ngosi maka ojiji. Edere Atomax n'ọnọdụ ndị dịka:

Cholesterol dị elu.
Mmụba LDL-C mụbara.
Mmụba na thyroglobulin na apolipropylene B.
Ọ bụrụ na ọkwa nke serum TG abawanye.
N'okwu ahụ mgbe dysbetalipoproteinemia malitere.

Atomax anaghị adị irè ma ọ bụrụ na onye ọrịa anaghị eso usoro nri pụrụ iche nke dọkịta nyere. Ọgwụ a bụ ihe inyeaka ma na-eme yana njikọta na nri nri pụrụ iche.

Etu esi ewere ma kedụ ọgwụ ole eji ọgwụ a? Tupu ịmalite usoro ọgwụgwọ, onye ọrịa ahụ kwesịrị ịgbanwe gaa nri pụrụ iche na-ebelata ume nri. Ndị dọkịta na-atụ aro ịgwọ ọrịa iche iche maka onye ọrịa ọ bụla. Enwere ike ị medicineụ ọgwụ ahụ tupu oge nri, ka emesịa, na tupu nri n'oge oge ọ bụla n'ụbọchị. Ofgwọ ọgwụ dị irè site na nke a anaghị ebelata.

Kedu ka Atomax si emeso ọgwụ ndị ọzọ? N'okwu ahụ mgbe ejiri ọgwụ ahụ jikọta ya na erythromycin ma ọ bụ ndị na-ahụ maka antifungal, mmetụta ndị dị n'ụdị myopia nwere ike ime. Ekwesighi iji Atomax mee ihe yana njikọta nke nwere hydroxide na aluminom, ma ọ bụghị ya, itinye uche nke atorvastatin n'ọbara na-ebelata yana nsonaazụ ọgwụgwọ, n'otu n'otu.

Enwere ike iji Terfenadine mee ihe, ebe ọgwụ a na-ajụ taa adịghị agbanwe Njirimara nke ndị bụbu. Enwere ike iji ya mee ihe na estrogens - ọ dịghị ihe dị njọ ga-eme.

Emegideghị Warfarin na Cimetidine.

Ejila ya na ndị na - egbochi ya, n'ihi na nchikota a na - eme ka ịba ụba nke Atomax dị n'ọrụ. Ọ dị mkpa ịhapụ ndị na - egbochi ya, ma ọ bụ belata usoro onunu ogwu. Ekwesịrị ime nke a n'okpuru nlekọta ndị dọkịta.

Ihe ngbanwe

Ihe mgbochi igbochi iji ogwu Atomax bụ: ọrịa ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba na ọrụ nke serum transaminases (karịa ugboro 3 ma e jiri ya tụnyere VGN) sitere na mmalite amabeghị, afọ ime, lactation, afọ n'okpuru afọ 18 (arụpụtaghị na ịdị mma na nchekwa), hyperensitivity na mmiri ọgwụ.
Jiri ịkpachara anya na-egbu egbu a ,ụrụma, na akụkọ banyere ọrịa imeju, nnukwu elektrọnte elektrik, endocrine na metabolic ọrịa, hypotension, nnukwu ọrịa (sepsis), ọrịa na-achịkwaghị achịkwa, nnukwu ịwa ahụ, mmerụ ahụ, na ọrịa akwara.

Ime

Atomax contraindicated maka iji n'oge ime na lacting (inye ara).
Amabeghị ma atorvastatin na-apụ apụ na mmiri ara. N’enye ohere nke ihe ojoo n’ime ụmụ aka, ọ bụrụ na ọ dị mkpa, iji ọgwụ n’oge a na-enye nwa ga-ekpebi nkwụsị nke ị breastụ ara.
Mụ nwanyị nke afọ omumu kwesịrị iji ụzọ zuru oke nke mgbochi afọ n'oge ọgwụgwọ. Enwere ike ịgwa Atorvastatin ụmụ nwanyị toro afọ ịmụ nwa naanị ma ọ bụrụ na ịmụ nwa ga-adị obere, a na-emekwa ka onye ọrịa mara ihe ọghọm dị na ọgwụgwọ nke nwa ebu n’afọ.

Mmekọrịta na ọgwụ ndị ọzọ

Agbanyeghị, mmetụta dị ala nke njikọta nke atorvastatin na colestipol karịrị nke ọgwụ ọ bụla n’otu n’otu.
Site na nchịkwa nke digoxin na atorvastatin ugboro ugboro na 10 mg, ikike itinye digoxin na plasma ọbara agbanweghị. Ka osi di, mgbe eji digoxin na atorvastatin na onwa 80 mg / ubochi, ntughari nke digoxin riri elu dika 20%. Ekwesịrị ị hụ ndị ọrịa na-anata digoxin yana atorvastatin.
Iji otu oge atorvastatin na erythromycin (500 mg 4 ugboro / ụbọchị) ma ọ bụ clarithromycin (500 mg 2 ugboro / ụbọchị), nke na-egbochi CYP3A4, mmụba na plasma nwere mkpokọta nke atorvastatin.
N'iji oge nke atorvastatin (10 mg 1 oge / ụbọchị) na azithromycin (500 mg 1 oge / ụbọchị), itinye uche nke atorvastatin na plasma ọbara agbanweghị.
Atorvastatin enweghị mmetụta ọfụma na ụlọ ọrụ gbasara mkpokọta nke terfenadine na plasma ọbara, nke CYP3A4 metabolized ka ukwuu; n'akụkụ a, ọ bụ eleghi anya na atorvastatin nwere ike imetụta parameters nke ọgwụ ndị ọzọ CYP3A4 ndị ọzọ.
Site n'iji atorvastatin na oge onyunyo ogwu nke nwere norethindrone na ethinyl estradiol, ọnụọgụ AUC nke northindrone na ethinyl estradiol hụrụ ihe dịka 30% na 20%, n'otu n'otu. E kwesịrị ịtụle mmetụta a mgbe ị na-ahọrọ ọgwụ mgbochi nwanyị maka nwanyị na-anata atorvastatin.
Enweghị mmekọrịta dị egwu dị n'etiti atorvastatin na estrogens hụrụ.
Mgbe ị na-amụ mmekọrịta nke atorvastatin na warfarin na cimetidine, enweghị mmekọrịta dị oke egwu a hụrụ.
Site n’otu oge eji atorvastatin na dose nke 80 mg na amlodipine na dose nke 10 mg, ọgwụ ọgwụ nke atorvastatin na steeti oruru agbanwe agbanwebeghị.
Ihe eji emeju atorvastatin nwere ihe mgbochi nchebe nke a maara dị ka ndị na - egbochi CYP3A4 tinyere mmụba nke mkpokọta plasma nke atorvastatin.
Onwebeghi mmetụta ọjọọ dị na ọgwụ ọjọọ nke atorvastatin na ndị na-egbochi ihe ọgụ.

Mwepụta wepụtara ya na ihe mejupụtara

Atomax bụ ọgwụ achọrọ iji gbochie HMG-CoA reductase, na-ebute mbelata nke cholesterol na sel imeju. N'adịghị ka statins nke ọgbọ mbụ, Atomax bụ ọgwụ nke sitere na sịntetik.

Na ahịa ọgwụ, mmadụ nwere ike ịchọta ọgwụ ọgwụ ụlọ ọrụ India HeteroDrags Limited na osisi ụlọ nke OJSC NIZHFARM, LLC Skopinsky Pharmaceutical Plant.

Atomax dị n'ụdị mbadamba ọcha nke gbara agba gburugburu akụkụ ya. Site n’elu kpuchie ha akpụkpọ ihe nkiri.Otu ngwugwu nwere mbadamba iri atọ.

Mbadamba ụrọ ahụ gụnyere 10 ma ọ bụ 20 mg nke ihe na - arụ ọrụ - atorvastatin calcium trihydrate.

Na mgbakwunye na akụrụngwa bụ isi, mbadamba ihe ọ bụla na shei ya nwere ụfọdụ ego:

sodium croscarmellose,
mee ka talcum ntụ ntụ dị ọcha
lactose n'efu
stereta magnesium,
ọka ọka
carbon dioxide
povidone
silikon dioxide anakpo ahihia,
crospovidone
triacetin

Na mgbakwunye, a na-etinye ụfọdụ etu titanium dioxide na nkwadebe.

Usoro nke ihe eji arụ ọrụ

Dịka anyị kwuru na mbụ, a na-enweta mmetụta mmachi nke Atomax site na igbochi HMG-CoA reductase. Ebumnuche bụ isi nke enzyme a bụ ịtụgharị methylglutaryl coenzyme A ka mevalonic acid, nke bụ usoro nke cholesterol.

Atorvastatin na-arụ ọrụ na mkpụrụ ndụ imeju, na-ebelata ego nke LDL na mmepụta cholesterol. Ejiri ya maka ndị ọrịa na-arịa ọrịa hypercholesterolemia, nke enweghị ike ịgwọ ya na ọgwụ ndị ọzọ belata cholesterol. Mgbanwe nke mbelata cholesterol na-adabere na oke nke ihe bụ isi.

Atomax adighi akwado ka ewere ya n’oge nri, dika iri nri na - ebelata oke nke mmiri. Ngwakọta ahụ na-arụ ọrụ na-etinye obi gị dum na ngọngọ nri. A na-ahụ ọdịnaya kachasị nke atorvastatin ruo awa 2 mgbe etinyere ọrụ.

N'okpuru nduzi nke enzymes pụrụ iche CY na CYP3A4, metabolism na-eme na imeju, n'ihi nke a na-emepụta metabolites parahydroxylated. Mgbe ahụ, ewepụrụ metabolites ahụ n’onwe ya yana bile.

Ihe ngosi na contraindications maka iji ogwu

Ejiri Atomax belata cholesterol. Dọkịta na-edepụta ọgwụ ọgwụ na nri nri maka ọrịa ndị dị ka isi, heterozygous ezinụlọ na hypercholesterolemia na-abụghị nke ezinụlọ.

Iji mbadamba ụrọ dịkwa mkpa maka ụba mkpụrụ nke thyroglobulin (TG), mgbe ọgwụgwọ nri anaghị ebute nsonaazụ ha chọrọ.

Atorvastatin na -ebelata cholesterol nke ọma na ndị ọrịa nwere hypercholesterolemia homozygous familialia, mgbe ọgwụgwọ na nri anaghị agwọ onwe ya.

A machibidoro Atomax ụfọdụ ụdị ndị ọrịa. Ntụziaka ahụ nwere ndepụta nke contraindications maka iji ọgwụ ahụ:

Childrenmụaka na ndị nọ n’agbata afọ 18.
Oge ị ga-amụ nwa na inye ya ara.
Hepatic dysfunction nke amaghi.
Ọgwụ mkpuchi nke ihe ndị dị na ngwaahịa ahụ.

Ejiri ọgwụ ahụ jiri nlezianya mee ihe banyere hypotension akwara, nleghara anya nke electrolytes, malfunctions nke usoro endocrine, ọrịa imeju, a chronicụrụma na-adịghị ala ala na Akwụkwụ na - enweghị ike ịchịkwa.

Ntuziaka maka iji ọgwụ ahụ

Isi ihe dị mkpa na ọgwụgwọ Atomax bụ idebe nri pụrụ iche. Ihe oriri na-edozi ahụ iji belata oriri nke nwere cholesterol dị elu. Ya mere, nri anaghị ewepụ iri viscera (akụrụ, ụbụrụ), yolks akwa, bọta, anụ ezi, wdg.

Usoro onorvastatin dịgasị iche site na 10 ruo 80 mg. Dịka iwu, dibịa bekee depụtara ọgwụ izizi nke 10 mg kwa ụbọchị. Ọtụtụ ihe na-emetụta usoro ị aụ ọgwụ, dị ka ọkwa nke LDL na cholesterol zuru oke, ebumnuche ọgwụgwọ na arụmọrụ ya.

Ibawanye usoro ogwu nwere ike rụrụ mgbe ụbọchị 14-21 gachara. N'okwu a, ntinye nke lipids na plasma ọbara bụ ihe amanyere.

Mgbe ọgwụgwọ 14 gachara, a na-achọpụta mbelata nke cholesterol, mgbe ụbọchị iri abụọ na abụọ gachara, a na-enweta ike ọgwụgwọ kachasị. Site na usoro ọgwụgwọ ogologo oge, metabolism metabolism na-alaghachi na nkịtị.

Must ga-echekwa ọgwụ a ebe a na-echekwa ya site na obere ụmụaka. Usoro nchekwa nke nchekwa dị iche na 5 Celsius Celsius.

Ndụ shelf bụ afọ abụọ, mgbe oge a gasịrị, amachibido ị medicineụ ọgwụ ahụ.

Ihe Pot Pụrụ Ime na do Overụbiga mmanya ókè

A machibidoro ịnwe nchịkwa nke ọgwụ maka ọgwụgwọ ọgwụ ọgwụ.

Mgbe ufodu, ogwu nwere ike ibute mmeghachi omume ojoo n’onye oria.

Tupu iji Atomax, ịkwesịrị ịgakwuru dọkịta gị.

Akwụkwọ ntụziaka a na - ekwupụta omume enwere ike ịme ụdị mmetụta ndị a:

Ọgba aghara nke usoro akwara dị n’etiti: ọrịa asthenic, ụra na-adịghị mma ma ọ bụ ụra, ụra abalị, amnesia, dizziness, isi ọwụwa, ịda mba, tinnitus, nsogbu obibi, paresthesia, neuropathy akụkụ, uto ọgba aghara, ọnụ akọrọ.
Mmeghachi omume metụtara akụkụ anụ ahụ na -akụ ahụ: mmepe nke ntị chiri, nkụkpọ nkụ.
Nsogbu nke akwara na akwara obara: aholebonia, anemia, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, ubara obi obi, arrhythmia.
Dysfunction of the digestive tract and biliary system: afọ ntachi, afọ ọsịsa, ọgbụgbọ na ọgbụgbọ, mgbu nke afọ, hepatic colic, belching, obi mgbawa, ịba ụba gas na -eme, nnukwu pancreatitis.
Mmeghachi omume nke anụ ahụ: itching, ihe ọkụ ọkụ, eczema, mgbu nke ihu, eserese.
Nsogbu nke uru ahụ: akwara olu nke ala akụkụ ahụ, azụ mgbu nke nkwonkwo na azụ, myositis, rhabdomyolysis, ogbu na nkwonkwo, iwe nke gout.
Urination na-enweghị nsogbu: urination na-egbu oge, cystitis.
Ọkpụkpụ nke plọgum lab: hematuria (ọbara na mmamịrị), albuminuria (protein na mmamịrị).
Mmeghachi omume ndị ọzọ: ọbara mgbali elu, agụụ mmekọahụ na-ebelata, dysfunction dysfunction, alopecia, sweating riri nne, seborrhea, stomatitis, goms ọbara ọgbụgba, eriri akụkụ, ikpu na imi.

Atụ atorvastatin dị elu na-eme ka ohere nke akụrụ ghara ibilite, yana ọrịa myopathy (ọrịa neuromuscular) na rhabdomyolysis (ogo nke myopathy).

Ruo ugbu a, enweghi ọgwụ pụrụ iche maka ọgwụ a.

Ọ bụrụ n ’ihe ịrịba ama nke ịdoụbiga mmanya ókè, a ga-ewepụ ha. N'okwu a, ọrịa ịba ọcha n'anya anaghị arụ ọrụ.

Mmekọrịta na ọgwụ ndị ọzọ

Ihe ike ọgwụ na-arụ ọrụ nwere ike ịmeghachi n'etiti onwe ha n'ụzọ dị iche iche, n'ihi nke ọgwụgwọ nke Atomax nwere ike iwusi ike ma ọ bụ mee ka ọ daa mba.

Ohere iji mekọrịta n'etiti ihe dị iche iche nke ọgwụ dị iche iche chọrọ ka onye ọrịa ahụ kọwaara dibịa na-aga ahụ maka ị medicationsụ ọgwụ na-emetụta ọrụ Atomax.

Ntuziaka maka ojiji nke ọgwụ hypoliplera, enwere ozi zuru oke banyere njikọta ya na ọgwụ ndị ọzọ.

Ejikọtara ọnụ na cyclosporine, erythromycin, fibrates na ndị na-egbochi antifungal (otu ìgwè nke ihe mgbu) na-amụba ohere nke neuromuscular pathology - myopathy.
N'oge nyocha, otu oge nlekọta Antipyrine anaghị eme mgbanwe dị ukwuu na ọgwụ ọgwụ. Ya mere, a na-anabata nkwonkwo ọgwụ abụọ.
Yiri ojiji nke ihe na-egbochi ihe nwere magnesium hydroxide ma ọ bụ aluminom hydroxide na-eduga n'ịbelata ọdịnaya nke atorvastatin na plasma.
Njikọ nke Atomax yana ọgwụ mgbochi afọ ime nke nwere tinylestradiol na norethindrone na-abawanye AUC nke ihe ndị a.
Ojiji nke colestipol n’otu oge belata ogo atorvastatin. N'aka nke a na-eme ka mmerụ ahụ dị ala belata.
Atomax nwere ike ịmụba digoxin na n'ọbara. Ọ bụrụ na ọ dị mkpa, ịgwọ ọgwụ a kwesịrị ka ọ bụrụ nlekọta ahụike siri ike.
Njikwa nje ọzọ nke Azithromycin anaghị emetụta ihe ndị dị na Atomax nọ n'ọrụ na plasma ọbara.
Ojiji nke erythromycin na clarithromycin na-eme ka mmụba nke ọkwa nke atorvastatin dị n’ọbara.
N'oge nyocha nke ụlọ ọgwụ, achọpụtaghị mmeghachi omume kemịkal n'etiti Atomax na Cimetidine, Warfarin.
A na-achọpụta mmụba na ọkwa nke ihe na-arụ ọrụ na nchikota nke ọgwụ yana ndị na-egbochi nchebe.
Ọ bụrụ na ọ dị mkpa, dọkịta na-enye gị ohere ikpokọta Atomax na ọgwụ, nke gụnyere Amplodipine.
Emebeghị nnyocha banyere otú ọgwụ si emekọrịta ọgwụ ọgwụ mgbochi.

Site na njikọta nke Atomax na estrogens, enweghị ihe ọjọọ ọ bụla hụrụ.

Ọnụahịa, nyocha na analogues

O nweghi ihe omuma banyere odi nma nke iji Atomax na intaneti. Eziokwu ahụ bụ na ka ọ dị ugbu a, a na-eji ihe oyiyi ọgbọ IV eme ihe na ahụike. Ọgwụ ndị a nwere usoro onunu ogwu ha, ha anaghị akpata ọtụtụ nsonaazụ.

Atomax siri ike ịzụta na ụlọ ahịa ọgwụ nke obodo n'ihi eziokwu ahụ bụ na ọ dịchabeghị eji ya. Na nkezi, ọnụahịa nke ngwugwu (mbadamba 30 nke 10 mg) sitere na 385 ruo 420 rubles. Ọ bụrụ na ọ dị mkpa, enwere ike inye ọgwụ ahụ ntanetị na weebụsaịtị nrụọrụ weebụ nke ndị nrụpụta.

Onu ogugu n’ilele banyere ihe nlere na egbusi ike n’ogugu ha. Maka oge kachasị, ha na-ekwu maka omume nke mmeghachi omume ọjọọ mgbe ha na-a theụ ọgwụ ahụ. Agbanyeghị, enwere echiche dị iche.

N'ihi contraindications dị iche iche na mmeghachi omume na-adịghị mma, mgbe ụfọdụ, dọkịta na-edepụta otu okwu (ọgwụ nwere otu ihe ahụ na-arụ ọrụ) ma ọ bụ analog (nke mejupụtara ihe dị iche iche, mana na-ewepụta ụdị ọgwụgwọ ahụ).

Enwere ike ịzụta okwu Atomax ndị a na ahịa ọgwụ Russia.

Atovastatin (Mba. 30 na 10 mg - 125 rubles),
Atorvastatin-Teva (Mba. 30 maka 10 mg - 105 rubles),
Atoris (Nọmba 30 maka 10 mg - 330 rubles),
Liprimar (Nke 10 na 10 mg - 198 rubles),
Novostat (Mba. 30 maka 10 mg - 310 rubles),
Tulip (Nke 30 maka 10 mg - 235 rubles),
Torvacard (Nke 30 maka 10 mg - 270 rubles).

N'etiti analogues nke Atomax dị irè, ọ dị mkpa ịmata ọdịiche dị iche iche ọgwụ ọjọọ:

Akorta (Mba 30 maka 10 mg - 510 rubles),
Krestor (Nke 7 maka 10 mg - 670 rubles),
Mertenil (Nke 30 maka 10 mg - 540 rubles),
Rosuvastatin (Mba. 28 na 10 mg - 405 rubles),
Simvastatin (Mba. 30 na 10 mg - 155 rubles).

N'ịga ọmụmụ ọgwụ Atomax nke ọma, ntuziaka maka ojiji, ọnụahịa, analogues na echiche nke ndị na - ere ahịa, onye ọrịa ahụ, ya na ndị ọkachamara na - aga ya, ga - enwe ike iji echiche ichebara mkpa ị forụ ọgwụ ahụ.

Enyere ozi banyere akpụ na vidiyo na edemede a.