Metfogamma® 850 (Metfogamma® 850)

Otu mbadamba ihe nwere:

Ihe na-arụ ọrụ: metformin hydrochloride - 850 mg.

Ndị pụrụ iche: hypromellose, povidone, magnesium stearate.

Ihe mejupụtara Shell: hypromellose, macrogol 6000, titanium dioxide (E 171).

Mpempe akwụkwọ na-acha ọcha na-acha ọcha, ihe mkpuchi na-acha uhie uhie, na eriri nke mmebi n'akụkụ abụọ, ọ fọrọ nke nta ka ọ bụrụ nke na-enweghị isi.

Omume ọgwụ

Metphogamma 850 bụ ọgwụ ọgwụ hypoglycemic nke sitere na ìgwè biguanide. Ọ na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na eriri afọ, na - eme ka ojiji nke glucose na - emeju kwa oge, na - emekwa ka ọ nwee ọgụgụ isi nke insulin. Agbanyeghị, ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ beta nke pancreas. Na-ebelata ọkwa nke triglycerides na obere lipoproteins dị ala n'ime ọbara. Na-eme ka ahụ gị dị ike ma ọ bụ belata ya. O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye ọgwụ ahụ site na eriri afọ. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ -50-60%. Oke ndọta na plasma ọbara erutela elekere 2 mgbe ịbatara. Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọta na gland salvary, imeju na akụrụ. Ọ bụ akụrụ na-agbanweghi agbanwe. Ọkara ọkara bụ awa 1.5-4.5.

Site na arụ ọrụ ezumike n’akuku nsogbu, ịnwe ọgwụ ọgwụ ga-ekwe omume.

Usoro onunu ogwu na nhazi

Ọtọ Metfogamma 850 ka edobere n’otu n’otu, na-eburu n’uche glucose dị n’ọbara. Ọgwụ nke mbụ na-abụkarị 850 mg (1 mbadamba) kwa ụbọchị, mmụba nke ịalụ ọgwụ ugboro ugboro ga-ekwe omume dabere na usoro ọgwụgwọ. Uche nkwanye ọgwụ a bụ 850-1700 mg (1-2 mbadamba) kwa ụbọchị. Oke kachasị kwa ụbọchị bụ 1700 mg (mbadamba abụọ), nhọpụta nke doses dị elu anaghị ewelie mmetụta nke ọgwụgwọ ahụ.

A na-atụ aro ka a na-atụ aro kwa ụbọchị karịa 850 mg na usoro onunu abụọ (ụtụtụ na mgbede). N'ime ndị ọrịa agadi, ọgwụ a na-atụ aro kwa ụbọchị ekwesịghị ịfe 850 mg.

Ekwesịrị iji nri mbadamba Methogamma 850 nri, dum, were obere mmiri washedacha ihe ọ downụ (ụ (iko mmiri). Ọgwụgwọ ya ọgwụ dị ogologo.

Mmetụta akụkụ

Site na eriri afọ: ọgbụgbọ, ọgbụgbọ, mgbu afọ, afọ ọsịsa, enweghị agụụ, ụtọ "ọla" n'ọnụ. N'ọnọdụ ndị a, ịkwụsị ọgwụgwọ ọgwụgwọ anaghị achọkarị ya, ihe mgbaàmà ahụ na-edozi onwe ha na-enweghị ịgbanwe ọgwụ. Ugboro na ogo mmetụta ya na eriri afọ nwere ike wedata jiri mmụba nwayọ nwayọ na usoro metformin.

Mmeghachi omume nfụkasị ahụ: ọnya anụ ahụ.

Site na usoro endocrine: hypoglycemia (tumadi mgbe ejiri ya na usoro ezughị ezu).

Metabolism: n'ọnọdụ ndị dị ụkọ, lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Site na usoro hemopoietic: n'ọnọdụ ụfọdụ - megaloblastic anaemia.

Dodoụbiga ya ókè

Site na mmachi nke Metfogamma 850, lactic acidosis nwere nsonaazụ na-egbu egbu ga-ekwe omume. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ. Ihe mgbaàmà mbido nke lactic acidosis bụ ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, ahụ ọkụ, ọnya afọ, olu mgbu, mgbe ahụ enwere ike ịba ụba iku ume, ọgbụgbọ, mmụọ na -eme ka ọ bụrụ mmepe nke akpịrị lactic acidosis, a ga-akwụsị ọgwụgwọ na Metfogamma 850 ozugbo. gwọọ onye ọrịa ahụ ngwa ngwa, ebe ọ buru n ’mkpebi nke lactate, gosipụta nchoputa ahụ. Measurezọ kachasị dị irè iji wepu lactate na Metphogamma 850 site n'ahụ ahụ bụ hemodialysis. A na-eme ọgwụgwọ Symptomatic. Site na usoro njikọta nke Metphogamma 850 yana nkwanye sulfonylurea, hypoglycemia nwere ike ịmalite.

Mmekọrịta na ọgwụ ndị ọzọ

Iji otu ihe eji eme ihe na - eme anwansi, ihe acorbose, insulin, ọgwụ mgbochi ọgwụ na - abụghị steroidal, MAO inhibitors, oxygentetracycline, ACE inhibitors, clofibrateeri, cyclophosphamide, B-blockers, ọ ga - ekwe omume ịbawanye hypoglycemic mmetụta nke metformin. Iji otu oge eji glucocorticosteroids, mgbochi ụbụrụ, epinephrine, sympathomimetics, glucagon, homonụ thyroid, thiazide na "loop", ntụpọ phenothiazine, nciotinic acid, ọ ga-ekwe omume ibelata mmetụta hypoglycemic mmetụta nke metformin.

Cimetidine belatara mkpochapu nke metformin, nke a na - ebute oke lactic acidosis.

Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin). N'ihi ị alcoholụ mmanya n'otu oge, lactic acidosis nwere ike ịmalite.

Njirimara ngwa

A naghị akwado ya maka ọrịa na-efe efe, na-aka njọ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala ala, mgbe egosipụtara ọgwụ insulin. Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha.

Ekwadoro iji Metfogamma 850 ka ọ dịkarịa ala ụbọchị 2 tupu ụbọchị abụọ mgbe x-ray ma ọ bụ nyocha nke redio na-eji ndị nnọchi anya. A naghị atụ aro ka ọ drugụọ ọgwụ ahụ na ndị ọrịa na nri nwere mmachi na oriri caloric (

Nhazi ọkwa nosological (ICD-10)

Mlọ ọgwụ

Ọ na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose site na eriri afọ, na - eme ka ojiji nke glucose na - emeju kwa oge, na - emekwa ka ọ nwee ọgụgụ isi nke insulin. Na-ebelata ọkwa nke triglycerides na obere lipoproteins dị ala n'ime ọbara. Ọ nwere mmetụta nke fibrinolytic (na-egbochi ọrụ nke plasminogen activator inhibitor anụ ahụ), na-eme ka ahụ sie ike ma ọ bụ belata ibu ahụ.

Ihe ngbanwe

ọrịa mamịrị ketoacidosis, precca mamịrị shuga,

oke akwara na enweghi nsogbu

obi na iku ume iku ume,

nnukwu frasi nke myocardial infarction,

nnukwu ọrịa ụbụrụ,

lactic acidosis na ngosipụta ya na akụkọ ntolite, ọnọdụ ndị nwere ike itinye aka na mmepe nke lactic acidosis, gụnyere egbu egbu egbu,

Nsonaazụ

Site na sisitemu obi na obara (hematopoiesis, hemostasis): n'ọnọdụ ụfọdụ megaloblastic anaemia.

Site na ngwara: ọgbụgbọ, ọgbụgbọ, mgbu afọ, afọ ọsịsa, enweghị agụụ, ụtọ dị n'ọnụ.

Site n'akụkụ nke metabolism: hypoglycemia, n'ọnọdụ ndị na-adịghị ahụkebe, lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Mmeghachi omume nfụkasị ahụ: akpukpo aru.

Ntụziaka pụrụ iche

A naghị akwado ya maka ọrịa na-efe efe ma ọ bụ njọ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala ala, tupu ịwa ahụ na n'ime ụbọchị 2 mgbe a gbasịrị ha, yana n'ime ụbọchị 2 tupu yana mgbe nyocha nyocha (ọgwụ na redio). iji ọdịiche nke mgbasa ozi). Ekwesighi iji ya mee ihe na ndi oria nri nwere mmachi nke caloric (erughi 1000 kcal / ubochi). A naghị atụ aro iji ọgwụ a eme ihe na ndị gaferela afọ 60 bụ ndị na-arụ nnukwu ọrụ anụ ahụ (n'ihi oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis).

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ. Enweghị mmetụta (mgbe eji ya monotherapy). Na mgbakwunye na ndị nnọchi hypoglycemic ndị ọzọ (usoro sulfonylurea, insulin, wdg), mmepe nke steeti hypoglycemic ga-ekwe omume, nke ike ịnya ụgbọ ala na itinye aka na ihe omume ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Emeputa

Werwag Pharma GmbH & Co. KG, Kalverstrasse 7, 71034, Beblingen, Germany.

Emeputa: Artesan Pharma GmbH & Co. KG, Wendlandstrasse, 1, 29439, Lyukhov, Germany.

Dragenopharm Apotheker Püschl GmbH & Co. KG, Gellstrasse, 1, 84529, Tittmoning, Germany.

CJSC ZiO-Zdorovye, Russia, 142103, Ógbè Moscow, Podolsk, ul. Ilzọ ụgbọ elu, 2.

Lọ ọrụ nnọchite anya / ụlọ ọrụ na-anabata nnabata: ụlọ ọrụ nnọchite anya ụlọ ọrụ Vervag Pharma GmbH & Co. CG na Russian Federation.

117587, Moscow, Warsaw awara awara, 125 F, bldg. 6.

Tẹ.: (495) 382-85-56.

Mpempe usoro onunu ogwu

Mbadamba ihe eji etinye fim, 850 mg

Otu mbadamba ihe

ihe na - arụ ọrụ - metformin hydrochloride 850 mg

(nke ruru metformin 662.8 mg),

ndị na-ebu ụzọ: hypromellose (15000 mPas), Povidone K25, magnesium stearate,

mejuputara sheath: hypromellose (5mPas), macrogol 6000, titanium dioxide (E171).

Mbadamba ụrọ a na-eji edochi anya biconvex kpuchie, kpuchie ya na ihe nkiri na-acha ọcha, nwere ihe egwu n'akụkụ ya abụọ, dayameta (7.5 ± 0,5 x 21.5 ± 0,5) mm na ogologo (6.0 ± 6.8) mm.

Ngwongwo ogwu

Mgbe nchịkwa ọnụ gachara, a na-anabata metformin na eriri afọ. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ 50-60%. Oke Csx nke nwere ike itinye uche n'ihe ruru awa abụọ na narị abụọ gachara. Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọta na gland salvary, akwara, imeju na akụrụ. A na-ebugharị Metformin na mkpụrụ ndụ ọbara uhie; sel ọbara ọbara nwere ike ịbụ ebe nchekwa nke abụọ. Ọ bụ akụrụ na-agbanweghi agbanwe. Nkera ọkara bụ awa 6.5. Ọ bụrụ na arụ ọrụ ezumike ezughị ezu, nchịkọta ọgwụ ga-ekwe omume. Echere na ọgwụ ọgwụ nke metformin adsorption abụghị nke ekwenyeghị.

Metfogamma® 850 na-egbochi gluconeogenesis na imeju, na-ebelata nnabata nke glucose site na eriri afọ, na-eme ka ojiji nke glucose na-emechi kwa oge, na-emekwa ka ikike nke anụ ahụ nwee insulin. Metformin na - akpali intracellular glycogen synthesis site na ị mee ihe na glycogen synthase, na - eme ka ikike ibu nke ụdị ndị na - ebugharị glucose protein na - ebuwanye ibu. Agbanyeghị, ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ beta nke pancreas. Lowers ngụkọta cholesterol, triglycerides na obere lipoproteins dị ala. Na-eme ka ahụ gị dị ike ma ọ bụ belata ya. O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.

Mpempe mwepụta, nkwakọ ngwaahịa na ihe mejupụtara Metfogamma ® 850

Mbadamba mbadamba, ndị nwere ihe mkpuchi na-acha ọcha na-acha odo odo, dị egwu, na-enweghị ihe ọ bụla.

Ndị pụrụ iche: hypromellose (1500CPS), hypromellose (5CPS), povidone (K25), magnesium stearate, macrogol 6000, titanium dioxide.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (6) - ngwugwu nke kaadiboodu.
10 PC. - blisters (12) - ngwugwu nke kaadiboodu.
20 nkp. - blisters (6) - ngwugwu nke kaadiboodu.

Usoro usoro onunu ogwu

Tọọ iche, ichebara ọkwa glucose dị n’ọbara.

Usoro izizi na-abụkarị 850 mg (1 tab.) / Day. Mmụba nke iji nwayọọ nwayọọ na-abawanye na ọgwụ ọ ga-ekwe omume dabere na nsonaazụ ọgwụgwọ. Usoro nlekọta ahụ bụ 850-1700 mg (1-2 mbadamba) / ụbọchị. Oke kachasị kwa ụbọchị bụ 2550 mg (3 mbadamba).

A na-atụ aro ka a na-atụ aro kwa ụbọchị karịrị 850 mg na ọgwụ mgbochi abụọ (ụtụtụ na mgbede).

N'ime ndị ọrịa agadi, ọgwụ a tụrụ aro agaghị agafe 850 mg / ụbọchị.

E kwesịrị iri nri dị ka Mpekere dị iche iche, were obere obere mmiri hichaa ya (iko mmiri).

A na-ezube ọgwụ a maka iji ogologo oge.

N'ihi ịba ụba nke lactic acidosis, n'ọrịa metabolic siri ike, a ga-ebelata dose ahụ.

Mkparịta ụka ọgwụ ọjọọ

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide na beta-blockers, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.

Site na iji GCS eme ihe n'otu oge, mgbochi ogwu a na-aralụ aineụ, epinephrine (adrenaline), sympathomimetics, glucagon, homonụ thyroid, thiazide na loopback diure, ntụpọ phenothiazine na nicotinic acid, mbelata mmetụta hypoglycemic nke metformin kwere omume.

Cimetidine belatara mkpochapu nke metformin, n'ihi ihe nke lactic acidosis na-abawanye.

Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin).

Site na nchịkwa oge nke ethanol, mmepe nke lactic acidosis ga-ekwe omume.

N'iji otu oge eme ihe nifedipine na –eme ka oriri nke metformin gharazie, C max, na - ebelata ekpomoku.

Ọgwụ cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ebugharị tubular na, site na usoro ọgwụgwọ ogologo oge, nwere ike ime ka C max metformin dịkwuo 60%.

Ihe ngosi maka ojiji

- ọgwụgwọ nke ụdị ọrịa shuga dị n'ọrịa 2 nke ndị okenye, ọkachasị na ndị ọrịa karịrị akarị, ọ bụrụ na iri nri na mmega ahụ anaghị enye njikwa glycemic zuru oke,

dị ka monotherapy ma ọ bụ na njikọta ọnụ na ọgwụ ndị ọzọ antidiabetic, ma ọ bụ insulin

Mkparịta ụka ọgwụ ọjọọ

Njikọ ọnụ na-anaghị akwadoro.

Intoxụbiga mmanya ókè na-eme ka ohere nke lactic acidosis ghara ịdị, karịsịa n'ihe ndị a:

- ụnwụ nri ma ọ bụ erighị ihe na-edozi ahụ,

Ọ dị mkpa iji zere ị ofụ mmanya na ọgwụ nwere mmanya na-agwọkwa metformin.

Iodine nwere ihe ndi ozo di iche

Intravascular iji iodine nwere ihe dị iche na - enwe nsogbu nwere ike ibute ọdịda akụrụ, na - eduga na nchịkọta nke metformin, yana ịbawanye n'ihe egwu nke lactic acidosis. Ekwesịrị ịkwụsị kwụsịrị iji metformin mee ihe tupu ojiji nke ndị nnọchianya dị iche iche, n'oge ọmụmụ ihe ha na iji ya na n'ime awa 48 mgbe ha gwụsịrị. Ekwesịrị ịga n'ihu na usoro ọgwụgwọ oge awa 48 mgbe njedebe nke ọmụmụ ahụ na ọ bụ naanị mgbe nyochachara nke abụọ nke ọrụ akụrụ wee nweta nsonaazụ nkịtị.

Mgwakọta ndị chọrọ mkpachapụ anya pụrụ iche mgbe ị na-eji

Ọgwụ na arụ ọrụ hyperglycemic ha dị ka ihe atụ, glucocorticoids (maka sistemu na mpaghara), beta-2 agonists, sympathomimetics.

Ekwesịrị ịgwa ndị ọrịa banyere nke a, na-atụ aro ka ha nyochaa ọkwa glucose ọbara karịa oge ụfọdụ, ọkachasị na usoro ọgwụgwọ mbụ. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịhazi oke usoro nke metformin n'oge ọgwụgwọ, karịsịa mgbe ị na-a anotherụ ọgwụ ọzọ na mgbe ịkwụsị ya.

Diuretics, ọkachasị akwara looure.

Ebe ọ bụ na enwere ohere ịnwelata ọrụ akụrụ, enwere nnukwu ihe ibute ọrịa lactic acidosis.

Ndị na - egbochi ihe ACE nwere ike ime ka mbelata ọkwa glucose ọbara. Ọ bụrụ na ọ dị mkpa, ekwesịrị idozigharị ọgwụ hypoglycemic ọgwụ n'oge ọgwụgwọ site na iji ndị na - egbochi ACE na mgbe ịkwụsị ọgwụ a.