Ole mgbe, aga m ewere mbadamba Hartil?

Hartil-D bụ antihypertensive ọgwụ na-enyekwa diuretic emereme. Ọgwụ mgbochi ihe ndị nọ n'ọrụ ọgwụ ahụ bụ emeju, ebe ramipril na-ebelata hypokalemic mmetụtahydrochlorothiazide.

Pharmacodynamics na pharmacokinetics

A na-eji ihe ndị dị n'ọrụ nke ngwa a maka ọbara mgbali elu.

Ramiprilat (nọ n'ọrụ) ramipril metabolite) obi erughi ala ACE. Na mgbakwunye, ọ na-ebelata ikuku. aldosterone. Ramipril na-emekwa ka ibelata na -akpata akwara vaskụla.

Ọtụtụ mgbe antihypertensive a na-ahụta ihe a na-eme ya ka awa 1-2 gachara. Ọ dịgide otu ụbọchị. A na-enweta ogo ogo ogo ihe dị ukwuu karịa awa 3-6. Site na usoro ọgwụgwọ ogologo oge, a na-ahụkarị ihe kachasị emetụta mgbe ihe dị ka izu atọ gasịrị. Site na usoro ọgwụgwọ ogologo oge, a na-edozi ya ruo afọ 2.

Hydrochlorothiazide mejuputara thiazide diuretic. Eleghi anya okike ya antihypertensive omume gụnyere ịgbanwe sodium nguzosi ike na nguzogide arịa nile nke akụrụ, yana ibelata ọkwa nke mmiri extracellular, plasma, na mmeghachi omume na angiotensin II na norepinephrine.

A na-ahụkarị mmetụta kachasị mgbe awa 3-6 gachara were ihe ruru awa iri na abụọ. Ọgwụ mgbochi A na-enweta nsonaazụ ahụ mgbe ụbọchị 3-4 nke ọgwụgwọ gasịrị ma na-ewe otu izu mgbe ọ gụsịrị akwụkwọ ahụ. Site na usoro ọgwụgwọ ogologo oge, mbelata ọbara mgbali a na-enweta ya site na iji obere dos karịa ka ọ dị mkpa maka diuretic mmetụta. Belata ọbara mgbali enwere mmụba dị ntakịrị na ọsọ ịlọ ụwaọrụ mmemme renin n'ime ọbara plasma mmegide vaskụla nke akwa gbasara akụrụ. Mgbe eji hydrochlorothiazide na usoro onunu ogwu di elu, a na-ebelata olu Plasma na ọsọ ịlọ ụwa, pụtara ọbara mgbali na ọbara gbasara akụrụ. Site na ọgwụgwọ ogologo oge na obere doses, olu nke plasma ọbara, systemic vaskụla nguzogide na pụtara ọbara mgbali dịrị nwayọ n'otu oge ọsọ ịlọ ụwa na obere olu laghachi ọkwa gara aga.

Ihe ngbanwe

A naghị akwado ngwa ọrụ a iji:

• cholestasis,
• Udeme nke Quincke n'ime akụkọ ihe mere emeyana kedike / idiopathic,
• nsogbu ndị dị mkpa n’ọrụ akụrụ,
• ngbaka,
• isi izizi,
• ịba ọcha n'anya,
• anabataghi galactose,
• ụkọ eketa lactases ma ọ bụ bụrụ nke malabsorption glucose galactose,
• inye ara,
• nke afọ ime,
• nwata
• oke arụmọrụ na imeju,
• hypotension akwara,
• ọnọdụ mgbe akụrụ akụrụ,
• anabataghị ọgwụ ndị dị na ọgwụ ahụ.

N'iji nlezianya dee, Hartil-D ka edepụtara maka ya aortic na mitral stenosis, ọrịa systemic nke anụ ahụ jikọrọ ọnụ, ọnya siri ike nke akwara ọbara na akwara ụbụrụ, decompensated "pulmonary obi", arrhythmias siri ike, mgbochi nke ụmị ọkpụkpụ. ihe abuostenosis akwara, gout, hyponatremia, hypercalcemia, gbasara akwara, cirrhosis nke imejuejighi ike angina pectorisala ala obi obara (agba nke anọ), mbelata Bcc, ọrịa shuganká mgbochi ọrịa obi na-egbochi hypertrophic, hyperkalemia, otu akụrụ akwara stenosis, hypokalemia, Ọrịa ụbụrụ Ischemic, imeju imeju.

Nsonaazụ

Mgbe ị na-a theụ ọgwụ na mmalite nke ọgwụ na mgbe ịba ụba onunu ogwu, akpọ hypotension akwara. Ọrịa nwere ike ịgụnye anya ntughariọhụhụ ụzọ, adịghị ike nke izugbe, ịda mba. Na mgbakwunye, ekwupụtala ihe mberede ọghọm nke ụbụrụ, tachycardia, arrhythmias, infarction myocardialpalpitations kwupụtaraọbara mgbali ike, angina pectoris na ujo. N'oge eji Ihe mgbochi ACE na hypotension akwara enwere ike obara na ụbụrụ na afọ ischemic.

Ihe mmeghachi omume ndị a na-esote:

• metabolism - hyperglycemiaụba acid na ọkwa hypokalemia, gout, hyperkalemia, hypomagnesemia, hypercalcemia, hyponatremia, hyperchloremia,
• sistemụ ụjọ - enweghị mmasịụjọ isi ọwụwaike ọgwụgwụ, mmetụta adịghị ike, iro ụra,
• akụkụ nke ọhụụ - conjunctivitis, ịba ọcha n'anya,
• sistem obi - mbelata di ukwuu ọbara mgbali, ọzịza nkwonkwo ụkwụ
• usoro iku ume - ọdịdị nke ụkwara akwara, ọla kọpa,
• Usoro nri - ọgbụgbọ, ọgbụgbọ, mgbu afọ, dyspepsiana-emegharị mpaghara epigastric, afọ ntachimmụọ, akpịrị ịkpọ nkụ, afọ ọsịsa,
• akpụkpọ integument - urticaria, ndise, itching,
• usoro urinary - proteinuria,
• usoro omumu - mbelata libido.

N'ọnọdụ ndị a na-adịghị ahụkebe, ihe ndị na-esonụ ga-ekwe omume:

• sistemụ ọbara na-efe efe (lymph sistem) na -elata n’ime afọ ojuju hematocrit na haemoglobin, thrombocytopenia, eosinophilia, leukopenia, pancytopenia, agranulocytosis,hemolytic anaemia (ọ bụrụ ụkọ dehydrogenase glucose-6-phosphate),
• metabolism na oriri na-edozi - mmiri na-adịghị mma-electrolyte, metabolic alkalosis, hypochloremiana-aba ụba ọdịnaya triglycerides na ogwe ya na ahihia amylases, hypercholesterolemiantụpọ ọrịa shuga mellitus,
• ụjọ ụjọ - ụjọ, enweghị atụ, isi, paresthesia,
• ahụ nke ọhụụ - myopia trensient,
• akụkụ anụ ahụ - na-anụ ntị na ntị,
• sisitemu obi - ike ngaghari nke mgbasa nke akwara, itu ukwu, nsogbu nke thromboembolic, vasculitis, thrombosisihe ojoo Ọrịa Raynaudọrịa vein embolism,
• usoro iku ume - ura ume, rhinitis, glossitisnfụkasị ọrịa mgbochi oyi, sinusitis, pharyngitis, bronchospasm, Udeme nke Quinckeeriri afọ
• akụkụ digestive - mgbochi ụta, ọnụ na -eme ihe, ọgba aghara, sialadenitisọgbụgbọ, mbufụt nke akpụkpọ ahụ mucous, ọbara ọgbụgba na-efe efe,
• imeju - mmụba ọrụ bilirubin umeji imeju, jalestice cholestatic, cholecystitis, ịba ọcha n'anya, negirosisi imeju
• akpụkpọ integument - systemic lupus erythematosus, erythema multiforme, iwepụta ihu, ịmụgharị akụkụ, ịsụsọ, Ọrịa Lyellihe ojoo psoriasis, Stevens-Johnson ọrịa, mmeghachi omume nfụkasị ahụ, alopecia, onycholysis,
• sistem mọzụlụ na anụ ahụ jikọrọ ya - spasm muscle, arthralgia, ọrịa ogbu na nkwonkwo, myalgiaike adighi ike ahụ mkpọnwụ,
• sistemụ urinary - arụ ọrụ ezughi oke ọrụ, akpọnwụ akpọnwụ, ịba ụba nke nitrogen residual serum creatinine, nephrotic syndromennukwu gbasara akwara, oliguria, interstitial nephritis,
• usoro omumu - enweghi ike,
• ndị ọzọ - anafilactic mmeghachi omume.

Udeme nke Quincke n'ọtụtụ oge na-apụta na ndị ọrịa nke agbụrụ Negroid. Na mgbakwunye, otu obere nwere angioedema ihu na oropharyngeal Mpaghara n'ihi oriri Ihe mgbochi ACE.

Site na nsonazụ akpọpụtara site na anụ ahụ, ịkwesịrị ịgakwuru onye ọkachamara.

A na-egosi nchọpụta ahụike mgbe jaundice na mmụba ọrụ enzymes imeju.

Ntụziaka maka iji Hartil-D (Usoro na usoro onunu ogwu)

A na-ezube ọgwụ a maka otu ugboro n'ụtụtụ yana oke mmiri mmiri. Ntụziaka maka iji Hartil-D na-akọ na iri nri anaghị emetụta nsonaazụ ya. Mbadamba enweghị ike ikewa n'ime akụkụ.

Were ngwa a naanị mgbe dọkịta kpebiri ị theụ ya na usoro ahụ. Dịka iwu, edepụtara 2.5 mg iji bido usoro ahụ ramiprilna 12.5 mg hydrochlorothiazide. Usoro usoro mmezi ahụ bụ otu ihe ma ọ bụ okpukpu abụọ okpukpu abụọ, n'otu n'otu, maka ihe ọ bụla dị n'ọrụ. Ogo a ga-abawanye ma ọ bụrụ na ọ dị mkpa na obere oge nke izu atọ. Usoro akwadoro usoro onunu a ka akwadoro kwa ubochi bu 5 mg. ramipril na 25 mg hydrochlorothiazide.

Maka ndị merela agadi, yana maka ndị ọ na-arụ ọrụ akụrụ na akụrụ, a na-ahọpụta usoro nke ọ bụla otu otu tupu ịgbanwee ọgwụ a gwakọtara ọnụ Khartil-D. Ọgwụ ya kwesịrị ịdị ntakịrị.

Dodoụbiga ya ókè

Mgbe ị na-a drugụ ọgwụ a na oke onunu ogwu, ihe ndị a ga - ekwe omume: njigide nke urinary, mbelata nke ukwuu ọbara mgbaliogwe arrhythmia, ọnọdụ ujo, ihe mgbochi ụta, elektrolyte, Coma, paresis, bradycardia, gbasara akwara.

A na-ewere usoro ọgwụgwọ ahụ iche iche. Dịka usoro izugbe, lavage gastric, sodium sulfate na unyi na-arụ ọrụ nwere ike ịkọwa ya. Na mgbakwunye, a na-eji ọgwụgwọ na-akwado nkwado.

Ramipril wepu ahu site na dialysis.

Site na mbelata dị egwu ọbara mgbali a na-eweghachi mmiri mmiri site na mmiri. Ọ bụrụ na nke a arụpụtaghị nsonaazụ achọrọ, nchịkwa intraven ga-ekwe omume. angiotensin II, catecholamines. Ọ dị ezigbo mkpa iji nyochaa Bcc, KShchS, diuresis, ọkwa nke electrolytes na glucose n'ọbara. Na siri ike bradycardia etinyere ihe eji eme ihe. Na hypokalemia kwesịrị ịmaliteghachi ọkwa nke potassium dị mma.

Na-eyi ndụ egwu angioedema Ihe ndị a na-emetụta:

• nchịkwa subcutaneous ruo 0,5 mg epinephrine ma ọ bụ nchịkwa ngwa ngwa adrenaline na njikwaECG na ọbara mgbali,
• mmeghe ọgwụ mgbochi ọgwụ
• nchịkwa intravenal ma ọ bụ intramuscular glucocorticoids,
• adrenaline enwere ike ịgbakwunye C₁ inactivatorọ bụrụ na onye ọrịa nwere ụkọ.

Mmekorita

Njikọ ramipril na diuretics nwere ike ịba ụba antihypertensive mmetụta. Na mgbakwunye, mbelata dị mfe omume ọbara mgbali. Ya mere, ọ dị mma izere ụdị njikọ a.

Ọgwụ mgbochi enwere ike imeziwanye mmetụta mgbe ejiri ya ramipril n'otu oge na osisi nitrates ma ọ bụ vasodilators. Na mgbakwunye, ọ na-ebelata ike mgbe a na-eri ya. Ndị NSAID. Ego ndị a nwekwara ike ibute na njikọ yana ramipril arụ ọrụ ezumike. N'ọnọdụ ndị a na-adịghị ahụkebe, kwuru gbasara akwara. Ihe ọghọm nke mmepe ya na-abawanye mgbe ị na-ewere Hartil-D Allopurinol (nwekwara ike ịpụta leukopenia) na Okirikiri. Ebe ikpeazu di kwa Lovastatinna trimethoprim nwere ike ibute na hyperkalemia. Leukopenia na - etolitekwa mgbe ejikọtara Hartil-D Procainamide, immunosuppressants na cytostatics.

Mmekorita ramipril yana nkwadebe lithium na-eduga na mmụba nke ọkwa lithium serum, mmepe nke mmetụta nsonye ga-ekwe omume. Agaghị atụkọta ngwakọta a, mana ọ bụrụ na ọ gaghị atụ anya, achọrọ ọnọdụ onye ọrịa. Xxụ mmiri lithium nwere ike ịba ụba nathiazide diuretics.

Nnukwu ọgbụgba mụbara site na mmekorita ramipril ya na ụfọdụ ọgwụ ịgwụ, ọgwụ antipsychotic pụtara na ọgwụ tricyclic antidepressants.

Ekwesịrị ilebara ọnọdụ onye ọrịa ahụ anya mgbe ejikọtara Hartil-D nnabata ọmiko. Mgbe gị na ya na-emekọ ihe hypoglycemic pụtara nwere ike ịbawanye mmetụta ha ruo mgbe ọdịdị hypoglycemia. Nke a ga - ekwe omume na mmalite nke usoro ọgwụgwọ yana ọrụ ezumike arụ.

Njikọ dialysis ya na Ihe mgbochi ACE contraindicated, dị ka nke a nwere ike iduga anaphylactoid mmeghachi omume.

Hydrochlorothiazide mgbe gị na ya na-emekọ ihe Amphotericin B, GKSlaxatives Carbenoxolonema obu Corticotropin nwere ike ibute enweghị usoro elektrolyte. Ma jikọta ya na nnu nnu, ọdịdị nke hypercalcemiaya na obi glycosides – mmachi dijitalụ na hypokalemiaya na Sotalolom – arrhythmiaya na salicylates - mụbara mmetụta ha na-egbu egbu na sistemụ akwara na-arụ ọrụ.

Egwu hydrochlorothiazide mbelata site na cholesterol biaghachi na Colestipol. Ya mere, n’agbata nnabata ha ọ dị mkpa ime ka ọdịiche dị n’otu ruo ọtụtụ awa.

Ihe a na-arụ ọrụ bụ Hartil-D na-akwalite nsonaazụ ahụ. anaghị eme ka akwara dị jụụ.

Ọzọkwa antihypertensive a na-ebelata mmetụta nke ọgwụ ahụ mgbe ejikọtara ya na sodium chloride.

Nyocha banyere Hartil-D

Nyocha nke Hartil-D na-egosi ịdị irè nke ọgwụ a. A na-ahụta mmetụta ya site na mmalite nke usoro ahụ. Fọdụ ndị ọrịa, Otú ọ dị, chọrọ nhazigha usoro ọgwụgwọ, ebe ọ bụ na ịbelata oke mgbali ọbara ga-ekwe omume. Ọ bụ ya mere eji arụ ọrụ a ga-eji naanị n'okpuru nlekọta nke ọkachamara. Ọ bụrụ na ewere ya na ndụmọdụ nke dọkịta, ọ na - enyere aka nke ọma ọbara mgbali ike.

Ọnụahịa, ebe ịzụta

Ọnụ ego nke ngwaọrụ a na mbadamba 2,5 mgramipril na 12.5 mg hydrochlorothiazide - ihe dịka 300 rubles. Ọnụ ego mbadamba nkume nke 5 mg ramipril na 25 mg hydrochlorothiazide - ihe ruru 400 rubles.

Ngwakọta na usoro nke ime ihe

Otu mbadamba ihe n’ime ya ike iheDika ramipril na 5 mg ma obu 10 mg. Ndị enyemakaihe ndị mejupụtara ụlọ ọgwụ ọgwụ:

• sodium bicarbonate,
• sodium croscarmellose,
• sodium stearyl fumarate,
• pregelatinized stachi
• lactose monohydrate,
• iron oxide uhie,
• ọla edo oxide edo edo.

Ọgwụ nwere ike inwe mmetụta cardioprotective na angioprotective. Ọzọkwa, ọgwụ ahụ nwere ike ime ka usoro nke resorption nke clots ọbara dị na mgbidi nke arịa ọbara, na-ebibi oghere nke cholesterol, na-abawanye ụba nke fibrinogen ma belata usoro nke gluing sel, ya bụ, nchịkọta platelet.

Mmetụta dị mma nke iburu mbadamba mkpụrụ osisi Hartil na-amalite ịchọpụta mgbe 1-2 awa gachara. Ofdị irè nke ọgwụ ahụ na-adịgide ruo awa 24. Ngwongwo ihe ngborogwu nke ogwu a dabaghi ​​na okike, oke na afọ onye ọrịa na-anata ya.

Na nkọwa ndị ọzọ gbasara ramipril na akụrụngwa ọgwụ nwere ike ịchọta ya site na ilele vidiyo ọzọ.

Mpempe mwepụta

Ọgwụ dị n'ụdị mbadamba. N’ebe a na-ere ọgwụ ị nwere ike ịzụta nkwakọ kaadiboodu, nke gunyere mbadamba asaa nke odo pink ma ọ bụ oroma-pink na blisters.

Mbadamba nkume n’onwe ha nwere ọdịdị dị larịị, o nwere ike ihu n’elu ihe osise nke “R3”. Ọgwụ a nwere 5 mg nke isi ihe na - arụ ọrụ - ramipril.

Ọzọkwa na ahịa ọgwụ ị nwere ike ịzụta ngwungwu mbadamba ihe ọcha asaa nke otu ụdị oval, ma na-etinye akara "R4", nke pụtara na nkwadebe ahụ nwere 10 mg nke isi ihe na-arụ ọrụ.

N'ọnọdụ dị a areaa ka a na-ewere mbadamba Hartil?

Ndị dọkịta na-ede ọgwụ maka ndị ọrịa nwere ọrịa dịka:

• ọbara mgbali ike
• ọrịa obi na-adịghị ala ala
• ọrịa shuga,
• nkụchi obi na esite na nkụchi obi.

Cardiologists kwuru na ị pụ ọgwụ na-ebelata ohere nke nkụchi obi na ọrịa strok, ọbụlagodi na ndị ọrịa a wara ha ahụ.

Ime na lactation

A machibidoro ọgwụ Hartil-D ahụ n’oge afọ ime, yabụ ekwesịrị ịnọ n’ihu afọ ime tupu ịmalite ya. Ọ bụrụ na onye ọrịa ahụ chọrọ ịtụrụ ime, o kwesịrị ịkwụsị ị ACụ ọgwụ mgbochi ACE na hydrochlorothiazide ma were ọgwụ mgbochi ndị ọzọ dochie ha. Ọ bụrụ na ime amalitere mgbe ị na-a Hartụ ọgwụ ahụ Hartil-D, mgbe ahụ, ekwesịrị idochi ya ozugbo enwere ike (n'ọnọdụ ọ bụla, tupu ngwụsị nke ngụkọta nke mbụ) na ọgwụ na-enweghị ihe mgbochi ACE iji zere ihe ize ndụ nke mmebi nwa ebu n'afọ.

Ebe ọ bụ na ramipril na hydrochlorothiazide dị na mmiri ara, a naghị anabata inye ụmụ ara ara n'oge a na-agwọ ya Hartil-D.

Usoro onunu ogwu na nhazi

A ga-akpọrịrị Hartil-D kwa ụbọchị otu ugboro n'ụtụtụ. A ga-eloda mbadamba ndị ahụ na-enweghị ị cheụ mmiri ma na-a plentyụ nnukwu mmiri (ọbụlagodi otu iko iko). Enwere ike iwere mbadamba mkpụrụ osisi Hartil-D n'agbanyeghị nri ahụ: enwere ike iburu ha na afọ efu, n'oge nri ma ọ bụ mgbe nri ahụ gasịrị. Mbadamba nwere ike ikewa nkera abụọ, gbarie n'ihe ize ndụ.

Were Hartil-D, na-eleru dọkịta nke ọma. Ọgwụ ndị a na-ebido maka ndị okenye bụ 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide. Enwere ike ịbawanye dose ahụ n'etiti obere oge ma ọ dịkarịa ala izu atọ. Ọgwụ mmezi a na-eme bụ 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide ma ọ bụ 5 mg nke ramipril na 25 mg nke hydrochlorothiazide. Oke kachasị kwa ụbọchị bụ 10 mg ramipril na 50 mg hydrochlorothiazide. Ọ bụ dọkịta ga-ekpebi oge ọ ga-eji agwọ ọrịa.

Usoro ọgwụgwọ maka ndị ọrịa agadi na ndị ọrịa nwere umeji ma ọ bụ ọrụ akụrụ na-adịkarị ala karịa ka ọ dị na mbụ, ekwesịrị ịhọrọ dọkịta n'otu n'otu, na-eburu n'uche akụrụ na imeju na-arụ ọrụ.

Mmetụta akụkụ

Na usoro ọgwụ ndị a tụrụ aro, a na-anabata ọgwụ ahụ nke ọma. N'ọnọdụ ụfọdụ, ọdịdị nke mmeghachi omume na-adịghị mma ga-ekwe omume, nke na-anaghị achọ ịkwụsị ọgwụ. Ọ bụrụ na ị na-enweta oke nsonaazụ ma ọ bụ mmetụta na-ekwuputaghị na akwụkwọ ntuziaka a, kpọtụrụ dọkịta gị ma ọ bụ onye na-ere ọgwụ.

Na nmalite usoro ọgwụgwọ yana ịba ụba dose ahụ, mbelata ọbara mgbali elu nwere ike ịpụta - tolite hypotensionegosiputara site na nbudata dika nkpasu-iwe, ike adighi n'ohu, anya ohuru, mgbe ufodu na nkparita ma obu oria. Ohere puru iche banyere hypotension di ukwuu n’etiti ndị ọrịa nwere mmiri isi - nguzozi nke electrolyte, na nkụchi obi na-adịghị ala ala, na ọdịda akụrụ oke arụ. Site na mmepe nke hypotension, a ga-akwali onye ọrịa ka ọ na ọnọdụ kwụ ọtọ, ma ọ bụrụ na ọ dị mkpa, mee ka ọ bụrụ nkedo ọgbụgba iji mee ka ọbara na-ekesa olu. Oge mmeghachi omume hypotensive abụghị ihe mgbochi maka nchịkwa ọgwụ na-esote. Site na hypotension siri ike ma na-adịte aka, mbelata ọgwụ ma ọ bụ ịkwụsị ọgwụgwọ.

A maara na iwere ihe ndị na - egbochi ACE nwere ike sonyere ya akọrọ ụkwara, nke na-abawanye n’abalị na ọnọdụ dịkarịsịrị ala, bụ ihe kariri n’ebe ụmụ nwanyị na ndị anaghị a smoụ sịga nọ. Ukwara a na-apụkarị oge niile ịkwụsị ị ofụ ọgwụ ahụ. Oge ụfọdụ ụkwara nwere ike ịkwụsị mgbe agafere onye ọrịa na onye ọzọ na-egbochi ACE.

Ihe ndị a bụ mmetụta ndị ọzọ na-esokarị na-akọkarị n'oge ule ụlọ ọgwụ na ọgwụgwọ ọgwụgwọ nke ndị na-egbochi ACE, gụnyere ramipril na njikọ hydrochlorothiazide.

Ọrịa metabolism: mbelata nke ukwuu na mgbanye potassium n’ime ọbara, n’ọnọdụ ndị dị njọ na ọdụ ọdịdọ ma ọ bụ adịghị ike, mmụba nke ọkwa urea na creatinine n’ọbara, gout, mmụba nke ọkwa glucose n’ọbara, mmụba na-adịkarịkwa elu na ọkwa nke potassium n’ọbara.

Mmebi nke usoro ụjọ ahụ: dizziness, ike ọgwụgwụ, isi ọwụwa, adịghị ike, iro ụra.

Ọgba aghara site na sistem ụbụrụ: hypotension akwara, mbufụt nkwonkwo ụkwụ.

Ọrịa digestive: ọgbụgbọ, mgbu afọ, nsogbu nke nri afọ, afọ ime, akpịrị ịkpọ nkụ, afọ ntachi, afọ ọsịsa, agụụ.

Ọrịa akụkụ iku ume: ụkwara, ụkwara ume ọkụ, rhinitis, sinusitis.

Arụ ọrụ na-arụ ọrụ na ụlọ: arụ ọrụ ana - arụ ọrụ, ụba urea n'ọbara na ọbara creatinine, mmiri na-egbu.

Mmetụta erughị ala: conjunctivitis, ọrịa ịba ọcha n'anya, nkwarụ anya na-adịghị ala ala, tinnitus.

Mmeghachi omume niile nke anụ ahụ, mmeghachi ahụ nfụkasị, ọnya anụ ahụ: mmeghachi omume nfụkasị ahụ, karịa mgbe ọ bụla n'ụdị ọnya anụ ahụ, obere oge - urticaria, ọnya akpụkpọ ahụ tinyere ya na itching, ọdịdị nke vesicles ma ọ bụ mpaghara flakes, ọzịza nke akpụkpọ ahụ na mucous membranes, photoensitivity, sweating over over, pain mgbu, psoriasis exacerbation, systemic lupus erythematosus, vasculis.

Njirimara ngwa

N'oge ọgwụgwọ na Hartil-D nlekọta ahụike mgbe niile. Na mgbakwunye na ọbara mgbali, ọrụ akụrụ, ọnụọgụ ọbara na kwa usoro biochemical kwesịrị inyocha mgbe ụfọdụ. A ga-ewepụ mmebi nke mmiri - a ga - ewepụ nguzozi nke electrolyte tupu ị theụ ọgwụ ọjọọ.

Hartil-D nwere ike ịkpata mbelata nke ọbara mgbali elu, ọkachasị mgbe ị firstụchara ọgwụ mbụ ma ọ bụ mgbe ị takingụchara ọgwụ mbụ. Ikekwe ịmalite hypotension dị ukwuu na mbelata olu nke na-ekesa ọbara n'ihi mmiri mmiri na nnu pụrụ, na ndị ọrịa nwere ọrịa obi na-adịghị ala ala bụ ndị nwere ọbara mgbali nkịtị. Site na mmepe nke hypotension, a ga-akwali onye ọrịa ka ọ kwụ ọtọ, ma, ọ bụrụ na ọ dị mkpa, mgbanye intantira dị mkpa iji mee ka ọbara na-ekesa. Mmeghachi omume hypotensive nwa oge abụghị contraindication maka nchịkwa ọgwụ na-esote. Site na iji hypotension toro ogologo ma na-adakarị ala, ọ nwere ike ịdị mkpa iji belata ogo nke ọgwụ ma ọ bụ kwụsị ịgwọ ya.

N'okwu ndị a, a ga-elebara anya pụrụ iche mgbe ị na-eji ọgwụ Hartil-D:

- n'ime ndị ọrịa nwere akpịrị ịkpọ nkụn'ihe banyere afọ ọsịsa na ọgbụgbọ,
- na ndị ọrịa na-ewere diuretics,
- n’ime ndị ọrịa nwere nnukwu ikere homonụ adrenal cortex (Ọrịa Conn)
- n'ime ndị mmadụ nri nnu dị ntakịrịna - apleụ ọgwụ nri siri ike na potassiumpotassium ọgwụ
- n’ime ndị ọrịa na - ata ahụhụ gbasara ọbara ọgbụgbadị arọ obi obara, hypertrophic cardiomyopathy,
- n'ime ndị ọrịa nwere ọrịa shugandị kwesịrị ilebara ọkwa nke glycemia anya. Ọ nwere ike ịdị mkpa n’otu n’otu n’otu n’otu n’ họọrọ ịhọrọ ọgwụ belata shuga ma ọ bụ site na mbadamba mbadamba ịba n’ibu insulin.
- n'ime ndị ọrịa nwere systemic lupus erythematosus ma obu psoriasis iwe iwe nke ọrịa ahụ kwere omume.

A ga-ezere ya ịba ọcha n'anya megide usoro gbasara ọgwụgwọ ya na Hartil-D. Ọ bụrụ na mmiri dị mkpa, ịkwesịrị ị toụ ọgwụ ọzọ na - egbochi ọgwụ na - abụghị ọgwụ mgbochi ACE.

Ọ dị mkpa ịgwa dọkịta banyere ị Hartụ ọgwụ Hartil-D tupu ịwa ahụ na ahu izizi, tinyere usoro izizi nke usoro ezé.

Usoro ọgwụgwọ Hartil-D nwere ike ibute akọrọ ụkwaranke na-apụ n'anya mgbe ọ kwụsịrị ọgwụgwọ.

Hartil-D nwere lactose monohydrate. Ekwesịrị itinye nke a na usoro ọgwụgwọ nke ndị ọrịa nwere ụkọ lactase na ọrịa metabolic ndị ọzọ na-adịghị ahụkebe (galactosemia ma ọ bụ glucose / galactose malabsorption syndrome).

Ọ bụrụ n’ichefu ịdọrọ Hartil-D n’oge n’oge, were ọgwụ ndị echefuru ozugbo o kwere omume, werezie ọgwụ ahụ ka dọkịta gị gwara gị. Ọ bụrụ n ’usoro ọzọ ga-adịgide ọtụtụ awa ma ọ bụ oge abịala ị doseụ ọgwụ ọzọ mgbe ọ nwesịrị ọgwụ nwusiri, e werela okpukpu abụọ nke Hartil-D iji kwụọ ụgwọ furu efu ahụ. N'okwu a, tụfuo ọgwụ ole a na-ewereghị n'oge wee gaa n'ihu ị takingụ ọgwụ ahụ dị ka usoro oge a si dị.

Akwụsịkwala ma ọ bụ kwụsị iji Hartil-D na aka gị! Esskwụsị mbanye Hartil-D ma ọ bụ mgbanwe mgbanwe Ekwesịrị ịrụ dị ka enyere n'iwu ma nyochaa dọkịta.

Nchedo nchekwa

Mmetụta dị na iji akwọ ụgbọala ma ọ bụ igwe nwere ike ịdị ize ndụ

Hartil-D, dabere na mmeghachi omume nke otu onye na-a theụ ọgwụ ahụ, nwere ike inwe mmetụta ọjọọ na ike ịrụ ọrụ chọrọ mmụba nlebara anya. Na mbido ọgwụgwọ ya na Hartil-D ma mgbe ịbawanye ọgwụ ahụ, a naghị atụ aro ịkwọ ụgbọala ma ọ bụ rụọ ọrụ ndị ọzọ chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor. N’ọdịnihu, ike nke ị rụọ ọrụ dị n’elu na ịchọpụta usoro nchekwa ahụ ọ bụ dọkịta ga-eme ya n’otu n’otu.

Etu esi ewere?

Mpempe akwụkwọ Hartil nwere ike ị drunkụ mmanya mgbe ọ dị mma, ya bụ, ọ bụchaghị tupu nri, mgbe ọ gasịrị ma ọ bụ n'oge nri ya. Enweghị ike ị cheụ ọgwụ a, ị ga-eji mmiri dị ọcha swallowụọ mmiri ọgwụ niile.

Ahụhụ ndidi ọbara mgbali ike, onye na - ekwu okwu banyere obi ga - akwado ị drinkingụ ọgwụ mg 2,5 nke ọgwụ otu ugboro n’ụbọchị. Ọ bụrụ na ọ dị mkpa, mgbe ahụ ị doseụ ọgwụ a takenụrụ nwere ike jiri nwayọọ nwayọọ mụbaa. Ọ dị mma ịmara na ego ole Hartil na-ewe kwa ụbọchị ekwesịghị ịbụ karịa 10 mg.

Ahụhụ ndidi obi obara n'ụdị na-adịghị ala ala, dọkịta nyere iwu ị drinkụ mbadamba 1,25 mg kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, dibia ukwu na-abawanye ọgwụ a .ụrụ. Ngụkọta ọgwụ ị medicationsụ mmanya kwa ụbọchị ekwesịghị ịkarị 10 mg.

Onye tara ahụhụ obi ọgụ, Edere ọgwụ ahụ maka ụbọchị 2-9. Onye ọrịa ahụ kwesịrị ị drinkụ 2.5 mg nke ọgwụ ahụ ugboro abụọ n'ụbọchị. Ọ bụrụ na ọ dị mkpa, dibia ukwu nwere ike ịkwado Hartil ugboro abụọ.

Ndị ahụ na-arịa ọrịa nephropathy, ị ga-a 1.ụ 1.25 mg nke ọgwụ kwa ụbọchị. N'ọnọdụ ndị a na-adịghị ahụkebe na ọrịa a, a na-agbanwe ọgwụ ahụ ka 5 mg kwa ụbọchị.

Dị ka ihe mgbochi nke nkụchi obi ma ọ bụ ọrịa strok na Ọrịa obi Dọkịta nwere ike ịgwa onye ọrịa ka ọ Hartụọ Hartil na ọnụọgụ 2.5 mg kwa ụbọchị. Usoro ya nwere ike ịbawanye elu ma jiri nwayọ rute 10 mg.

Ojiji nke Hartil n’ime umuaka, n’oge di ime na n’ara nku

Amachibidoro ọgwụ a ị toụ n’oge ịmụrụ nwa na inye nwa ara. Hartil nwere ike kpasuo mmebi iwu nke mebiri akụrụ nke nwa amụrụ, belata ọbara mgbali ya. Ọzọkwa, ọgwụ ahụ dị ize ndụ n'ihi na ọ nwere ike inye aka na mmepe nke hyperkalemia na nwa ebu n’afọ, skull hypoplasia na nrụrụ ya, hypoplasia ngụgụ, ọrịa pathologies nke aka na aka.

Emebeghi nchekwa nke iwere Hartil na arụmọrụ ya n’agbata afọ 18. N'akụkụ a, ịnweghị ike iwere ya.

Nkwekọrịta contraindications na nsonaazụ ndị ọzọ

Ekwesighi iwe Hartil n'okwu ikpe ndị a:

• Akụkọ banyere anakpoede,
• hypersensitivity na bekee dị na ọgwụ,
• ime n’oge ọ bụla
• lactation
• stenosis nke akụrụngwa
• hyperaldosteronism,
• ọnụọgụ abụọ
• gbasara akwara
• ejikọtaghị hemodynamics.

Na mgbakwunye, ọgwụ a nwere ike ibute mmeghachi omume na-adịghị mma akụkụ ahụ mgbe ewere ya, nke nwere ike ịgụnye:

• na-ebelata ọbara mgbali elu
• arrhythmia
• thrombocytopenia
• orthostatic hypotension,
• ụba proteinuria,
• akọrọ ụkwara
• nsogbu ọnọdụ
• ọgba aghara dị na sistemụ mgbasa ozi,
• mụbara gbasara mkpofu ọdịda
• ịma jijiji
• rhinorrhea
• ischemia myocardial na ụbụrụ
• mbelata libido
• ọdịdị adịghị ike
• iro ụra
• ụjọ ụjọ
• nghọta nghọta site ịnụ ihe, ịnụ ísìsì, ụtọ na ọhụhụ,
• ogwe
• bronchospasm
• alopecia
• nkwarụ vestibular
• mbelata hemoglobin na hematocrit,
• rhinitis, sinusitis,
• ọla kọpa
• akwara mgbu
• hyponatremia,
• nri riri
• conjunctivitis
• ọgbụgbọ, afọ ọsịsa, ma ọ bụ afọ ntachi
• ura ume, afụ nkụ,
• hemolytic anaemia
• rashes, akpụkpọ itching.

N'ihi ọnụọgụgụ dị njọ nke omume ọ ga - ekwe omume mgbe ị na - ewere mbadamba nkume ndị ahụ, ịkwesịrị ị drinkụ ya, na - elele nchedo nchekwa. Ọ dị mkpa ịghọta na n'oge ịchọrọ Hartil, njikwa nke dọkịta dị mkpa. Nke a dị mkpa n'oge oge nke oge ọzọ usoro ị ofụ ọgwụ na-abawanye. N'ime awa asatọ ka ị takingụchara Hartil na ịba ụba, ịchọrọ oge ịlele ọbara mgbali anya na nyochaa ụkpụrụ na njirimara ndị ahụ.

Ọzọkwa, a na-ele dọkịta anya mgbe niile ka ndị ọrịa nwere akwara ọrịa akwara, gbasara akụrụ, ndị butere akụrụ ya.

A ga-ahapụ ọrụ dị iche iche chọrọ mmụba nke itinye uche maka oge ọgwụgwọ na ọgwụ ndị a.

Ndakọrịta Hartil na ọgwụ ọjọọ na mmanya

Nchịkọta aka nke mbadamba ọgwụ nwere ọgwụ dị iche iche ga-ekwe omume maka ahụike. Ma n'otu oge ahụ, ọ bara uru ịtụle na otu oge a ọgwụ na ọgwụ nke otu ọgwụ ọgwụ dị ka cytostatics na corticosteroids, na-eme ka ọdịdị nke mgbanwe na mejupụtara ọbara ma nwee ike ịkpata nsogbu dị iche iche na sistemụ ọbara.

Ọ dịkwa oke ize ndụ ijikọta ojiji nke ọgwụ a na insulin na ọgwụ ndị ọzọ iji lụso ọrịa shuga ọgụ, ebe ọ bụ na n'ọnọdụ a, enwere ọ̀dalata shuga dị n'ọbara, nke nwere ike ịdị ize ndụ.

Cardiologists kwusiri ike ka a kwụsị ịveraụ mmanya na-aba n'anya n'oge ị withụ ọgwụ ndị a, ebe ọ bụ na ha na-enyere aka ịbawanye ihe ọ ofụ alcoholụ mmanya na-aba n'anya.

A na-ere ọgwụ a n'ụdị ntọhapụ kwesịrị ekwesị n'ihe fọrọ nke nta ka ọ bụrụ ụlọ ahịa ọgwụ niile. I nwekwara ike ịzụta ọgwụ ahụ na ụlọ ahịa ọgwụ dị n'ịntanetị. Mgbe ị na-azụ ọgwụ, a chọrọ ka dọkịta de ya ọgwụ ga-enyere gị ya.

Ọnụ ego maka ọgwụ na-amalite site na 370 rubles na ụlọ ahịa ọgwụ na Moscow. N'ime ụlọ ahịa ọgwụ dị n'ịntanetị ị nwere ike ịzụta ọgwụ ntakịrị dị ọnụ ala - ọnụ ahịa ọgwụ na-amalite na 297 rubles.

Ọgwụ yiri ya na ụgwọ ha

Enwere ike ị nweta ọgwụ ndị a na analogues nke ọgwụ a:

• Amprilan - site na 220 rubles,
• Pyramil - site na 202 rubles,
• Tritace - site na 996 rubles,
• Dilaprel - site na 115 rubles,
• Ramimed - sitere na 280 rubles.

Tupu ịzụta analogues nke ọgwụ, ị ga-atụle dọkịta gị ma ọ bụrụ na ha nwere ike dochie ọgwụ a kpamkpam ma ọ bụ.

Hartil bụ ọgwụ nwere ike karịa, yabụ, ọ dị mkpa ị itụ ya naanị na nhọpụta nke dọkịta na-agwọ ma lekwa anya idebe usoro ịcribedụ ọgwụ ahụ. Ma ọ bụghị ya, ịnwere ike ịnweta mmepe nke mmeghachi omume ọjọọ.

Ngwakọta na ime ihe

Nkọwa ahụ kwuru na Hartil bụ otu nke ACE inhibitors. Ihe na-arụ ọrụ n'ime ihe mejupụtara ya bụ ramipiril. N'ihi igbochi enzyme nke angiotensin na-agbanwe, onye na-ahụ maka ọrụ nwere mmetụta hypotensive.

Attentionaa ntị! Ọgwụ na-amalite ibelata nrụgide n'ime awa 1.5-2 mgbe nchịkwa gasịrị. Mmetụta ikwuputa egwu na-amalite mgbe 3.5-6 na-adigide ruo awa 24. Hartil chọrọ iji oge niile na ogologo oge, ọ gaghị ekwe omume ị tabletsụ mbadamba okwu site na ikpe ruo na ikpe.

Na mgbakwunye, ramipyril:

• na-akwalite mgbanwe mgbanwe umeji umeji obi (na-eji ogologo oge),
• na-eme ka ọbara na-akpụ akpụ n'ime myocardium,
• na-ebelata ugboro ole arrhythmias,
• normalizes na nrụgide dị na Portal vein nwere ọbara mgbali Portal,
• na-egbochi mmebi nke ọrụ akụrụ na ndị ọrịa mamịrị.

Ihe ngosi maka ojiji

N'ịghọta usoro nke ọgwụ a, anyị na-atụle ihe ndị na-egosi maka iji ya.

• ọbara mgbali ike
• CHF,
• nnukwu ọrịa myocardial infarction, akụkọ banyere ọrịa strok na akụkọ ntolite (iji belata ihe ọghọm nke nsogbu nje vaskụla).
• nephropathy, gụnyere ọrịa mamịrị.

Dị Mwepụta

Emepụtara Hartil site na ụlọ ọrụ ọgwụ Hungarian EGIS Pharmaceuticals PLC. Naanị otu ụdị mwepụta bụ mbadamba ụrọ nke 5 ma ọ bụ 10 mg. Na ngwungwu kaadiboodu, na mgbakwunye na 28 pink pink ma ọ bụ mbadamba ọcha, enwere nkọwa zuru ezu maka iji. Ọnụ ego nke igbe dị 410 p. maka onunu ogwu nke 5 mg na 460 r maka 10 mg.

Attentionaa ntị! Ọ bara uru karị ịzụta mbadamba miligram 10. Enwere ike kee nke ọ bụla n'ime ọkara, na-agbagha n'ihe egwu.

Na mgbakwunye, usoro nke onye nrụpụtara nwere ọgwụ ọgwụ agwakọta nke sitere na ramipiril na ọgwụ ndị ọzọ na - egbochi mkpali:

• Hartil Amlo (AM) (ramipiril + amlodipine) 5 mg + 5 mg, 10 mg + 10 mg,
• Hartil D (ramipiril + hydrochlorothiazide) 2.5 mg + 12.5 mg, 5 mg + 25 mg.

Usezọ iji

A na-ewere Hartil ede ede na-ata ata, jiri mmiri saa ya (nnukwu ọnụọgụ, ihe dị ka 200-250 ml) mmiri. Ikwesiri ị drinkụ ọgwụ ahụ kwa ụbọchị, kwa awa 24.

Dọkịta depụtara usoro onyonye ya na oge ọ ga-an o maka onye ọrịa ọ bụla. Enyere ntuzi aka na tebụl dị n'okpuru.

Tebụl 1: Ndụmọdụ ọkọlọtọ maka usoro ịhọrọ Hartil:

Dị Mkpa! Achọrọ nlebara anya ka ịhọrọ usoro ọgwụgwọ nke Hartil maka ndị ọrịa agadi na-a diụ ọgwụ na-arịa ọrịa na-efe efe (nkụda obi, ịrụ ọrụ nke akụkụ ahụ somatic).

Ọgwụ ọbara mgbali elu na ndị ọrịa mamịrị

Hartil a dabara adaba maka ịgwọ ọrịa ọbara ọgbụgba n'ọrịa ndị agadi nwere ọrịa shuga 2?

Ndewo Na mkpokọta, ee: ọgwụ nwere mmetụta dị mma n'ọrịa mamroangiopathy na ọrịa mamịrị. Agbanyeghị, maka onye ọrịa ọ bụla, ekwesịrị ịhọrọ ọgwụ na-egbochi ihe ọkụkụ otu otu.

Na mgbakwunye, ojiji Hartil jikọtara ọnụ na ọgwụ ịba ọcha n'anya hypoglycemic na-eme ka mbelata nke glucose ọbara dị ukwuu. Ya mere, oge ụfọdụ, na-emegide usoro ọgwụgwọ ọgwụ, ọ dị mkpa iji dozie dose nke insulin.

Pharmacokinetics nke ọgwụ.

Ramipril
Egwu
Mgbe nchịkwa ọnụ gasịrị, ramipril na-abanye ngwa ngwa. Na-ekpe ikpe site na redioaktivu achọpụtara na mmamịrị mgbe abatasịrị nke ramipril akpọrọ (akụkụ akụrụ bụ naanị otu n'ime ọtụtụ ụzọ), opekata mpe 56% nke ọgwụ ahụ ka a na-etinye. Iri nri otu oge anaghị emetụta ịmịkọrọ.
Ramipril bụ prodrug, ọ na - eme metabolism n'oge "ụzọ mbụ" site na imeju, n'ihi nke naanị ramiprilat metabolite nọ n'ọrụ (n'ihi hydrolysis, ọkachasị na imeju). Na mgbakwunye na ịghọ metabolite na-arụ ọrụ nke ramiprilat, ramipril conjugates nwere glucuronic acid wee ghọọ diketopiperazine ester nke ramipril. A na-ejikwa glucuronic acid mee ka Ramiprilat gbanwee ma ghọọ diketopiperazine-ramiprilat (acid). N'ihi mmegharị / metabolism nke ramipril, bioavailability mgbe nchịkwa ọnụ dị ihe dịka 20%.
Cmax nke ramipril na plasma ruru n’ime elekere 1 mgbe nchịkwa a na-ekwu okwu. Cmax nke ramiprilat dị na plasma ruru n'ime awa iri abụọ na anọ mgbe ebido ramipril gasịrị.
Nkesa
Ihe jikọrọ protein ndị na-edozi ahụ maka ramipril na ramiprilat bụ ihe dịka 73% na 56%, otu isi.
N'ime nyocha, achọpụtara na ramipril dị na mmiri ara ara.
Ojiji
T1 / 2 nke ramipril bụ ihe dị ka awa 1. Mbelata nke mkpokọta ramiprilat na plasma ọbara bụ multiphase na okike. A na-egosipụta nkesa izizi na mkpochapụ mbụ site na T1 / 2 dị ka ihe ruru awa 3. Mgbe ahụ etiti oge (T1 / 2 ihe dị ka awa 15) na oge ikpeazụ, n'oge nke ramiprilat foduru na plasma ọbara dị ala (T1 / 2 - 4-5 ụbọchị), soro. ) Oge ikpeazu a bụ n'ihi nkewapụ nke ramiprilat site na ụlọ siri ike mana jupụtara na ACE. N'agbanyeghi oge iwepu oge, Css nke ramipril erute ihe dika ubochi ano ka ubochi obula nke 2.5 mg ma obu ihe karie. T1 / 2 dị irè (oke metụtara oke ịhọrọ) bụ elekere 13-17 ka ị multipleụsịrị ọtụtụ ọgwụ.
Mgbe nchịkwa ọnụ nke 10 mg nke ramipril akpọrọ, ihe dị ka 40% nke redioaktivu na-apụ n'anya site na eriri afọ yana 60% site na akụrụ. N'ime awa iri abụọ na anọ mgbe ọrịa sitere catheter na-egosipụta 5 mg nke ramipril na-egosipụta ihe na-emetụta ya, ogo ihe mwepụ nke ramipril na metabolites ya na akụrụ na bile hụrụ. Odika 80-90% nke metabolites nke akụrụ na bile nọchiri anya ramiprilat na ọgwụ maka ịba n’ihu ya. Glucuronide na akara dmietopiperazine nke ramipril gbara ihe dị ka 10-20%, na ramipril na-enweghị nchebe gbara ihe dị ka 2% nke ngụkọta ramipril ọnụ.

Usoro onunu ogwu na uzo icho ogwu a.

E kwesịrị iwere mbadamba 1 oge / ụbọchị kwa ụbọchị n'ụtụtụ, na-a plentyụ ọtụtụ mmiri mmiri. Enwere ike ị drugụ ọgwụ ahụ n'agbanyeghị nri. Mbadamba ụrọ e keghị ekewa n'ime akụkụ.
Maka ndị okenye, a na-atụ aro ị theụ ọgwụ Hartil-D naanị ka ịhọrọ nhọrọ nke usoro nke ọ bụla. Enwere ike ịbawanye dose ahụ n'etiti obere oge ma ọ dịkarịa ala izu atọ. Ọgwụ mbụ a na-ebido bụ 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide. Ọgwụ a na-ahụkarị bụ 2.5 mg nke ramipril na 12.5 mg nke hydrochlorothiazide ma ọ bụ 5 mg nke ramipril na 25 mg nke hydrochlorothiazide. Usoro a na-atụ aro ka ukwuu kwa ụbọchị bụ 5 mg nke ramipril na 25 mg nke hydrochlorothiazide.
Maka ndị ọrịa agadi na ndị ọrịa nwere CC site na 30 ruo 60 ml / min, a ga-eji nlezianya họrọ usoro nke ọ bụla n'ime mmiri (ramipril na hydrochlorothiazide) tupu ịbanye na ọgwụ ịjikọtara Hartil-D.
Ọgwụ nke Hartil-D kwesịrị ịdị obere ka enwere ike. Usoro a na-atụ aro ka ukwuu kwa ụbọchị bụ 5 mg nke ramipril na 25 mg nke hydrochlorothiazide.
A machibidoro Hartil-D ọrịa n'ime ndị ọrịa nwere ezigbo ọrụ mgbazinye nsogbu (CC erughị 30 ml / min / 1.73 m2).
Tupu ọ gbanwee na Hartil-D, ndị ọrịa nwere nsogbu imeju dị nro ma ọ bụ na-agafeghị oke kwesịrị ka enye ya ọgwụ ramipril.
Anaghị anabata ya ị Hartụ ọgwụ Hartil-D n’ime ndị ọrịa nwere nnukwu ọrụ imeju na / ma ọ bụ cholestasis.
A naghị akwado Hartil-D maka ụmụaka na ndị nọ n’afọ iri na asatọ (na-erubeghị afọ 18) n’ihi enweghị nchekwa na arụmọrụ dị mma maka otu afọ a.