Glipizide - ntuziaka maka ojiji, ihe mejupụtara, ngosipụta, analogues na nyocha

Na-akpali mwepụta nke insulin site na mkpụrụ ndụ beta nke na-arụ ọrụ. Ọ na -ebelata ọkwa nke haemoglobin glycosylated na ịba ụba glucose na ndị ọrịa nwere ụdị ọrịa mellitus na-abụghị insulin na-agbadata. Na-ebelata hyperglycemia mgbe nri-nri gasịrị, na-eme ka ịnagide glucose na nhichapụ mmịpụta nke mmiri na-adịghị ala (na obere ntakịrị). Nzaghachi insulinotropic na-amalite n'ime minit 30 mgbe nchịkwa ọnụ gasịrị, oge iji mee ihe otu obere ruru awa 24. Ọ dịghị emetụta profaịlụ nke plasma ọbara.

N'ime nnwale na oke na ụmụ oke na nha 75 ugboro dị elu karịa MPD, ọ naghị ebute ọrịa carcinogenesis ma ghara emetụta ọmụmụ (oke). Emere nnyocha banyere nje nje, na na vivo , ekpugheghị Njirimara mutagenic.

Isdị ngwa ngwa na-abanye ngwa ngwa kpamkpam. Iri nri anaghị emetụta ngụkọta oge niile, mana ọ na-agbada ya ruo nkeji iri anọ. C_max kpebisiri ike awa 1 1-3 mgbe otu ọgwụ were. Ndi_1/2 bụ awa 2–4. Mgbe ọ gbasịrị nwayọ nwayọ, ọ na-apụta n’ọbara mgbe awa 2-3 gachara, C_max Ọ na-eru mgbe awa 6-12. Ọ na-ejikọ protein protein plasma ọbara site na 98-99%. Olu nke nkesa mgbe nchịkwa iv bụ 11 L, nkezi T_1/2 - Oge awa 2-5. Nchikota Cl mgbe agwara otu ivish bụ 3 l / h. Biotrans gbanwee na imeju (ya na amaokwu nke mbụ - ntakịrị). Ihe na-erughi 10% na-agbanwegharị na mmamịrị na feces, ihe dị ka 90% dị n'ụdị metabolites na mmamịrị (80%) na feces (10%).

Mmetụta dị iche iche nke ihe Glipizide

Maka ụdị ngwa ngwa glipizide:

Site na ụjọ na akwara anụ ahụ: dizziness, isi ọwụwa, ehighi ura, ura, nchekasị, obi erughị ala, ọgba aghara, ọgba aghara, paresthesia, hypersthesia, veel n'ihu anya, mgbu anya, conjunctivitis, mbufụt azụ.

Site na sisitemu obi na obara (hematopoiesis, hemostasis): syncope, arrhythmia, ọbara ọgbụgba, akụrụngwa nke ọkụ dị ọkụ.

Site n'akụkụ nke metabolism: hypoglycemia.

Site na ngwara: anorexia, ọgbụgbọ, ọgbụgbọ, mmetụta nke ike dị na mpaghara epigastric, dyspepsia, afọ ntachi, ọbara ọgbụgba na stool.

Na akpukpo ahu: ọnya, urticaria, itching.

Site na usoro iku ume: rhinitis, pharyngitis, dyspnea.

Site na usoro mkpụrụ ndụ: dysuria, mbelata libido.

Ndị ọzọ: akpịrị ịkpọ nkụ, ịma jijiji, akụkụ ụkwara akwara, ihe mgbu na - abụghị mpaghara niile, arthralgia, myalgia, cramps, sweating.

Maka ụdị ngwa ngwa glitizide:

Site na ụjọ na akwara anụ ahụ: isi ọwụwa, nkụchi, iro ụra.

Site na sisitemu obi na obara (hematopoiesis, hemostasis): leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic ma ọ bụ aplastic anaemia.

Site n'akụkụ nke metabolism: ọrịa shuga insipidus, hyponatremia, ọrịa porphyrin.

Site na ngwara: ọgbụgbọ, ọgbụgbọ, mgbu epigastric, afọ ntachi, ịba ọcha n'anya nke ọrịa (ọnya na-acha odo odo na sclera, mmụba nke stool na ọchịchịrị nke mmamịrị, mgbu na hypochondrium dị mma).

Na akpukpo ahu: erythema, maculopapular fash, urticaria, photoensitivity.

Ndị ọzọ: mmụba na mkpokọta nke LDH, alkaline phosphatase, bilirubin na-apụtachaghị ìhè.

Mmekorita

Ralnweta mineral, glucocorticoids, amphetamines, anticonvulsants (ọgwụ hydantoin), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, ọgwụ mgbochi, epinephrine, ethacinic acid, giurimmeme, thymo gland, triamteren na ọgwụ ndị ọzọ na - ebute hyperglycemia. Anabolic steroid na androgens na-eme ka ọrụ hypoglycemic dịkwuo elu. Anticoagulants na-apụtaghị ìhè, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin na-eme ka mkpokọta nke irighiri irighiri ọbara dị n'ọbara (n'ihi nchụpụ pụọ na protein plasma) ma mee ngwa ngwa biotransformation. Ketonazole, miconazole, ngọngọ sulfinpyrazone na-abawanye ma bulie hypoglycemia. Na ị Againstụbiga mmanya ókè, mmepe nke ọrịa disulfiram dịka ọrịa afọ, afọ mgbu, ọgbụgbọ, isi ọwụwa) ga - ekwe omume. Ọgwụ Antithyroid na ọgwụ myelotoxic na-eme ka ohere nke ịmalite ịrịa agranulocytosis, nke ikpeazụ, na mgbakwunye - thrombocytopenia.

Dodoụbiga ya ókè

Ọgwụgwọ: mwepu ọgwụ, nnabata glucose na / ma ọ bụ mgbanwe nri n’ime ya na nlezianya nyocha nke glycemia, na nnukwu hypoglycemia (coma, ihe ọdịdọ) - ụlọ ọgwụ ozugbo, nchịkwa nke glucose ọgwụ dị 50% na ntanetị ọnụ (iv drip) nke 10% ngwọta glucose dị mkpa iji hụ na ịbara glucose ọbara dị elu karịa 5.5 mmol / l, nlekota glycemia dị mkpa ruo ụbọchị 1-2 mgbe onye ọrịa ahụ hapụsịrị. Dialysis adighi ike.

Ọnụahịa dị na ahịa ọgwụ

Lelee ọnụahịa nke Glipizide na 2018 na analogues dị ọnụ ala >>> ofgwọ nke Glipizide n'ụlọ ahịa dị iche iche nwere ike ịdị iche. Nke a bụ n'ihi iji ihe ndị dị ọnụ ala na amụma ọnụahịa nke agbụ ụlọ ahịa ọgwụ.

Gụọ ozi gbasara gọọmentị banyere Glipizid, ntuziaka maka ojiji nke gụnyere ozi gbasara izugbe na usoro ọgwụgwọ. Edere ederede maka ebumnuche ọmụma ọ bụ naanị enweghị ike iji dochie anya ndụmọdụ ahụike.

Omume ọgwụ

Ngwunye ọgwụ hypoglycemic nke na-ahụ maka ọnya, ihe dị na usoro nke usoro nke n'ọgbọ nke abụọ. Na-akpali mmiri ọgwụ insulin site na sel-nke pancreas, na-abawanye ntọhapụ nke insulin. Ọ na-eme ka ahụrịị anụ ahụ dị elu na insulin. Ọ nwere hypoliplera, mmetụta fibrinolytic, na-egbochi nchịkọta platelet. Mgbe nchịkwa ọnụ gasịrị, glitizide na-agbakarị ngwa ngwa na ngụgụ nri.
Ejikọtara ndị na-edozi plasma (ọkachasị na albumin) bụ 98-99%.
Metabolized na imeju. Ihe na-erughị 10% dị na mmamịrị ma na-agbanwe agbanwe na-agbanweghi agbanwe, ihe dị ka 90% dị na mmamịrị (80%) yana feces (10%) dị ka metabolites.

Ofzọ nke ngwa

Maka ndị okenye: Tọọ iche iche dabere na onyonyo onyonyo nke ọrịa. Usoro ọgwụgwọ mbụ bụ 2.5-5 mg 1 oge / ụbọchị 15-30 nkeji tupu nri ụtụtụ. Ọ bụrụ na ọ dị mkpa, enwere ike iji nwayọ were nwayọ (ya na obere oge) gbadaa site na 2.5-5 mg / ụbọchị. Shouldbọchị ọ bụla kariri 15 mg kwesịrị ka ekee ya abụọ.
Ogwu kachasị: otu - 15 mg, kwa ụbọchị - 40 mg.

- Type 2 diabetes mellitus (non-insulin-based) na ndị ọrịa nwere oke ibu ma ọ bụ oke ahụ dị oke mma na usoro ọgwụgwọ nri anaghị arụ ọrụ.

Ihe omuma banyere ihe

Glipizide bụ aha azụmaahịa nke ọgwụ nwere ihe otu aha, mana ọ bụ akụkụ nke ọgwụ ndị ọzọ.

Ihe mejupụtara akụkụ ahụ bụ mmetụta hypoglycemic mmetụta, nke a na-enweta n'ihi nsonaazụ ya na mkpụrụ ndụ akwara. Nsonaazụ nke a bụ njikọ insulin.

A na-anọchi anya ihe ahụ n’acha ọcha na-enweghị ntụpọ. Ejiri ya na solubility na mmiri ma ọ bụ mmanya. Akụkụ ahụ na-emekọrịta ihe na protein dị n'ọbara, na-eme ka ọ bụrụ metabolites. A na-eme ozuzu nke akụrụ.

A na-emepụta Glipizide na mbadamba nkume nwere ọdịnaya nwere ọrụ nke 5 na 10 mg. Ngwa inyeaka nwere ike ịdị iche site na aha ọgwụ.

Nsonaazụ

- Site na usoro endocrine: adịkarịghị - hypoglycemia (karịsịa na ndị agadi, ndị ọrịa na-esighi ike, na-eri nri oge na-adịghị mma, na-a alcoholụ mmanya, imeju na-arụ ọrụ na akụrụ).
- Site na usoro digestive: ọgbụgbọ, afọ ọsịsa, ụkwara nta - ịba ọcha n'anya.
- Site na usoro haemopoietic: n'ọnọdụ ụfọdụ - thrombocytopenia, leukopenia, agranulocytosis.
- Allergic Jeremaya mere: adịkarịghị - akpụkpọ ahụ ọkụ, itching.
- Ndị ọzọ: isi ọwụwa.

Ntụziaka maka ojiji

A na-ezube ọgwụ a ịlụ ọgụ maka ọrịa shuga 2, ọ bụrụ na usoro ọgwụgwọ anaghị eweta nsonaazụ.

Ana mburu mbadamba nkume ndị ahụ, obere oge tupu nri, a withụọ ọgwụ iji mmiri. Usoro onunu ogwu dabere na njirimara onye ọrịa. A na-atụkarị aro ka ịmalite site na iji 5 mg kwa ụbọchị.

Site na arụmọrụ na-ezughi oke na ntachi obi dị mma, enwere ike ịbawanye usoro onunu ogwu ka 15 mg kwa ụbọchị. A na-ahapụ ya ka ị were ọgwụ ahụ otu oge, ị nwekwara ike kee nkesa ahụ n'ọtụtụ usoro.

N'ọnọdụ ụfọdụ, ọgwụ Glipizide kwesịrị ibelata. Ya mere, ekwesighi ịmalite ọgwụgwọ na-enweghị nkwenye nke ọkachamara - na-enweghị ihe ọmụma ọgwụ ọ siri ike ịtụle njirimara nke foto ụlọ ọgwụ.

Erere ọgwụ na - esite n'ihe a na-achọghị, ma ọ bụrụ na nke a mee, egbula okpukpu abụọ.

Ntuchi ogwu na ihe ojoo

N'agbanyeghị uru nke ọgwụ a maka ọrịa shuga, enwere ikpe mgbe amachibidoro iji ya.

Isi contraindications nke Glipizide gụnyere:

• anabataghị ihe mejupụtara ahụ,
• ọrịa shuga ketoacidosis
• ọrịa mamịrị
• tụụrụ ime
• nri eke
• ụdị shuga 1
• ihe ogwugwo
• nnukwu mmerụ ahụ
• ahụ ọkụ.

Mmachibido iwu iji ọgwụ a bụ n'ihi ihe egwu nke nsonaazụ na-adịghị mma nke nwere ike ime.

Otu n'ime ha kwuru:

• isi ọwụwa
• anya ntughari
• ike ọgwụgwụ,
• iro ụra
• ọnọdụ obi mgbawa
• ndaba,
• nchegbu
• conjunctivitis
• ihe mgbu n'anya
• mbufụt,
• mebiri na ngwu,
• ọgbụgbọ
• urticaria
• itching
• akpụkpọ anụ ahụ,
• rhinitis
• mmụba mgbali elu
• arrhythmia,
• mbelata libido
• ịba ụba,
• hypoglycemia.

Ọtụtụ n'ime mmebi ndị a adịghị ize ndụ, mana na-eweta ahụ erughị ala. Ndị ọzọ nwedịrị ike ime ka onye ọrịa ahụ nwụọ ma ọ bụrụ na enyeghị nlekọta ahụike. Ya mere, tupu ị drugsụ ọgwụ ọgwụ ndị nwere glitizide, ịkwesịrị ịgakwuru dọkịta gị ma chọpụta otu esi ewere ha nke ọma. Mana ọbụlagodi na ọ bụrụ ọkachamara ọkachamara edepụtara ọgwụ ahụ, ịkwesịrị iji nlezianya nyochaa ọdịmma gị. Etechọpụta ihe mgbaàmà ọjọọ bụ ihe kpatara ịchọ enyemaka.

Anaghị anabata ọgwụ a na-atụle ya mgbe niile. Ọ bụrụ na enwere contraindications, ọ dị mkpa iji ihe ọzọ dochie ya.

Otu n'ime analogues nke Glipizide nwere ike ịkpọ:

1. Glibenclamide. Ejiri ọgwụ gosipụtara mmetụta hypoglycemic, nke a na-enweta n'ihi ọdịnaya nke glipizide n'ime ya. Nke a pụtara na Minidiab bụ analog zuru oke nke mbadamba ụrọ ndị echebara echiche na ihe mejupụtara ya, na ntụzịaka ya bụ otu. Ọgwụ bụ otu n'ime ihe dị oke ọnụ; ị ga-akwụ ihe dịka 1,500 rubles maka nkwakọ.
2. Metformin. Ngwakọta ya na-arụ ọrụ bụ metformin umi. Ọ na - egbochi imeju na - arụ ọrụ nke glucose na - arụ ọrụ, na --emekwa ka ọnụnọ anụ ahụ nwee insulin. A na-ere ọgwụ ahụ n'ụdị mbadamba ọnụ ahịa nke 90-105 rubles.
3. Maninil. Ndabere nke ọgwụ a bụ glibenclamide. Mwepụta ya ga-abụ aka ike na ụdị mbadamba. Na mgbakwunye na hypoglycemic, ọ nwere mmetụta cardioprotective na antiarrhythmic. Ọnụahịa ahụ dịgasị iche site na 95 ruo 120 rubles.
4. Ọrịa. Ihe bụ isi ya bụ metformin. Ọgwụ nwere mpempe mbadamba, nke ezubere maka nchịkwa ọnụ. Ọ nwere mmetụta hypoglycemic dị n'ime. A na-ere ha dịka ọgwụ nke ọkachamara na-akwụ maka ihe dị ka ruble 120.
5. Glidiab. Nke a bụ analog ọzọ mejupụtara nwere otu ihe eji arụ ọrụ. Na-akwalite njikọ nke insulin n'ime ahụ, wee si na-ebelata glucose ọbara. Ọnụ ego ahụ bụ ihe dịka 100-120 rubles.

Vidiyo site na ọkachamara ahụ:

Ọgwụ ndị a niile nwere ike ibute nsonaazụ akụkụ, nke kachasị njọ nke bụ hypoglycemia. Ha nwekwara contraindications. Ya mere, ịkwesịrị iji ha naanị site n'ikike nke dọkịta na dịka ntuziaka ahụ si dị. Anaghị anabata ya iji aka gị dochie onye ọgwụ edepụtara maka ya, ọ nwere ike ibute nsogbu.

Mpempe mwepụta

Mbadamba 0.005 g (5 mg) na ngwugwu nke iberibe iri atọ.

Ihe omuma ndi di na peeji a ị na-eleputa bu n’ihi ihe omuma nke ihe omuma, n’oru adighi kwa ogwu nke onwe. Ebumnuche a bu iji mee ka ndi okacha mara ahuike mara ihe banyere otutu ogwu, si otu a bulie ogo oru ha. Iji ọgwụ ọjọọ eme ihe Glipizide na-agbadokarị maka inye gị ndụmọdụ maka ịmụrụ anya, yana ndụmọdụ ya gbasara usoro iji ya na usoro ị doụ ọgwụ ọgwụ ị họọrọ siri dị.

Efu, nyocha na analogues

Ebe ọ bụ na glipizide bụ akụkụ dị ike, enwere ike ịchọta ọtụtụ ọgwụ nwere ihe dị otú ahụ na ahịa ọgwụ Russia. Dịka ọmụmaatụ, Glucotrol CL na Glibenez Retard. Dabere n'ụdị ntọhapụ, ọnụahịa ọgwụ Glucotrol CL sitere na 280 ruo 360 rubles, na Glibenez Retard - site na 80 ruo 300 rubles.

Nyocha nke ọtụtụ ndị ọrịa mamịrị lụrụ ụdị ọgwụgwọ a bụ afọ ojuju. Agbanyeghị, ọtụtụ ndị chọpụtara na ọgwụgwọ ọgwụgwọ nke glipizide na-ebelata ka oge na-aga, yabụ a na-ejikarị ya na ọgwụ ndị ọzọ na-arịa ọrịa shuga. Otu n'ime uru ọgwụ dị nwere ike ịpụta ọdịiche dị mfe iji yana ọnụ ahịa na-eguzosi ike n'ihe nke ọgwụ nwere glitizide.

N'okwu ahụ mgbe otu ọgwụ adịghị mma n'ihi contraindications ma ọ bụ mmeghachi omume na-adịghị mma, dọkịta depụtara analog. Ọgwụ ndị a gụnyere:

Enweghị nkwenye nke dọkịta, ọgwụ ịchọrọ onwe ya adịghị mma. Nkwadebe nke nwere glitizide nwere ike inwe mmetụta ọjọọ n'ahụ ahụ mmadụ. Site n'iji ọgwụ n'ụzọ ziri ezi, ị nwere ike mee ka ọkwa shuga dị ka ọ dị mma ma wepụsịa ihe mgbaàmà nke ọrịa shuga. Mana anyị agaghị echezọ gbasara ọgwụgwọ mmega ahụ maka ọrịa shuga na ezigbo nri.

Na vidiyo dị n'isiokwu a, dọkịta ga-ekwu maka ọgwụ maka ọrịa shuga.