Telmisartan (Mikardis)

Nkọwa nke metụtara 04.11.2016

• Aha Latin: Telmisartan
• Usoro ATX: C09CA07
• Arụ Ọrụ: Telmisartan (Telmisartan)
• Emeputa: Osisi ọgwụ ọgwụ TEVA, JSC maka Ratiopharm International GmbH, Hungary / Germany

Dabere n'ụdị ntọhapụ, otu mbadamba ihe nwere 80 ma ọ bụ 40 mg nke ihe na-arụ ọrụ.

Mlọ ọgwụ

Telmisartan bụ onye anakpo angiotensin II na-anabata antagonist. Ọ na asọmpi ya na angiotensin maka ijikọ ndị na-anabata ndị ọrụ AT1. Enweghi mmekorita ya na ndi nnata ozo kwuru.

Telmisartan anaghị egbochi ọrụ nke renin, ACE, anaghị egbochi ọwa ndị na-eduzi ion, belata ọdịnaya aldosterone n'ime ọbara.

Mpempe ọgwụ nke 80 mg fọrọ nke nta ka ewepụsịrị mmụba ahụ ọbara mgbalikpatara angiotensin II. Mmetụta kasịnụ na-adịgide 24 awa, mgbe ahụ jiri nwayọọ nwayọọ belata. N'okwu a, a na-ahụ mmetụta dị ukwuu nke ọgwụ ahụ ọ dịkarịa ala awa 48 mgbe ịrechara mbadamba.

Telmisartan na -ebelata ma nrụgide systolic na diastolic, mana anaghị emetụta ọnụego nsị. Onweghi ihe riri ahu ma obu mmubanye aru n’ahu ahu.

Mlọ ọgwụ

Mgbe imesịrị ya, a gwọọ ọgwụ nke ọma yana ngwa ngwa. Bioavailability dị ihe dịka 50%. Ọ na-ejikọ nke ọma na protein plasma.

Oke kachasị nke plasma na-adịkarị elu karịa ụmụ nwanyị mgbe ha na-ewere otu usoro ego. Mana nke a anaghị emetụta arụmọrụ ya.

Metabolism pụtara na imeju. Nke a bụ adịghị arụ ọrụ metaboliteKpochapụ nke na - aputakarị na eriri afọ. Ọkara ọkara nke anụ ahụ bụ ihe dịka awa iri abụọ.

Ihe ngosi maka ojiji

A na-eji ya agwọ ọbara mgbali ike yana igbochi onwu site na oria obi na akuko ọrịa strok, obi ọgụọrịa ọgbụgba aka ekpe ventricular hypertrophy.

Ihe ngbanwe

Amachibidoro ịdebe Telmisartan na:

• igbochi oria nke biliary tract,
• siri ike imeju imeju,
• isi aldosteronism,
• fructose anabataghị ya,
• oke uche maka ihe arụ ọrụ ma ọ bụ ihe ọ bụla ọzọ dị na ọgwụ ahụ,
• nke afọ ime,
• n'okpuru afọ 18.

Nsonaazụ

Mmetụta ndị dị ụkọ adịghị ụkọ.

Otu n'ime ndị ọrịa 100-1000 na-a theụ ọgwụ nwere mgbaama ndị a:

N'ime 1 nke 1000-10000 ndị ọrịa hụrụ:

• urinary na akụkụ iku ume na-efe efe (ahu otutu, pharyngitis, sinusitis) ma ọ bụ sepsis,
• thrombocytopenia,
• mbelata larịị haemoglobin,
• obi uto
• nsogbu ndị a na-ahụ anya
• tachycardia,
• wedata ọbara mgbali mgbe ị na-agbanwe ọnọdụ nke anụ ahụ (site na kehoraizin na vetikal),
• afọ erughi ala
• ọnụ kpọrọ nkụ
• ọrụ imeju na-arụ ọrụ,
• mmụba nke imeju enzymes,
• ịba ụba plasma ịta uric acid,
• nkwonkwo mgbu
• erythema,
• angioedema,
• rashes na-egbu egbu,
• eczematous rash.

Nsonaazụ ndị ọ dịkarịsịrị ike ma ọ bụ ndị ụda ya na-enweghị ike ikpebi nke ọma:

• Ọkpụkpụ akwara yiri ya tendonitis,
• ụba nke eosinophils n'ime ọbara.

Mmekorita

Mmekọrịta nke Telmisartan na ọgwụ ndị ọzọ:

• Baclofen, Amifostine na ndị ọzọ antihypertensive ndị nnọchi anya - a na-eme ka mmetụta hypotensive dịkwuo mma,
• barbiturates, ọgwụ narcotic, ethanol na antidepressants - ngosipụta nke hyperension orthostatic na-akawanye njọ ma ọ bụ ihe na-akpata ya na-abawanye,
• Furosemide, Hydrochlorothiazide na ụfọdụ ndị ọzọ diuretics - na hypotensive na-abawanye,
• Digoxin - ịba ụba ịta Digoxin na plasma
• Nkwado lithium - mmụba mgbanwe nke lithium n'ọbara, nyocha nke ihe ngosi a dị mkpa,
• NSAIDs - ihe ize ndụ nke nnukwu ihe mgbaàmà na-abawanye gbasara akwaraọkachasị na akpịrị kpọrọ nkụ
• potassium na-eme ka ọnụọgụ, potassium, Heparin, Cyclosporin, Tacrolimus, Trimethoprim - ụba ịba uru nke potassium na ọbara n'ọbara,
• GCS - a na-ebelata antihypertensive mmetụta,
• Amlodipine - arụmọrụ nke Telmisartan na-abawanye.

Omume ọgwụ

Angiotensin II onye na-anabata antagonist.

Telmisartan bụ onye na - emegidekarị ndị nnabata angiotensin II. Ọ nwere oke mmekọrịta maka AT1 receptor subtype nke angiotensin II, site na nke a na-ahụ ihe omume nke angiotensin II. Telmisartan na-ewepu angiotensin II site na njikọ ya na onye na-anabata ya, na-enweghị ọrụ onye na-ahụ maka nnwere onwe n'ihe metụtara onye nnabata a. Telmisartan na-ejikọ naanị na AT1 receptor subtype nke angiotensin II. Bgba agba na-aga n'ihu. Telmisartan enweghị mmekọrịta maka ndị na-anabata ndị ọzọ (gụnyere ndị na-anabata AT2) na ndị na-anabata angiotensin na-erughị ọmụmụ. Ọdịghị uru ọrụ nnabata ndị a bara, yana nsonazụ ha nwere ike ime nke ọma na angiotensin nke abụọ, agụchabeghị nke a na-abawanye na nhọpụta nke telmisartan. Ọ na-ebelata itinye uche nke aldosterone n'ọbara, anaghị egbochi mmiri renin na plasma ọbara ma ọ dịghị egbochi ụzọ ion, anaghị egbochi ACE (kininase II, enzyme nke na-ebibikwa bradykinin). Yabụ, atụghị anya mmụba nke mmetụta n'akụkụ bradykinin kpatara.

Telmisartan na dose 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. A na-achọpụta mmalite nke hypotensive n'ime ọnwa 3 mgbe nchịkwa izizi nke telmisartan. Mmetụta ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo ihe dị ka awa 48. Mmetụta hypotensive na-amalitekarị izu 4-8 mgbe ị regularụsịrị ya.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata systolic na ọbara mgbali, na-enweghị emetụta mmetụ obi.

N'ihe banyere kagbuo telmisartan na mberede, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya na-enweghị mmepe nke ọrịa mwepụ.

Usoro onunu ogwu na nhazi

Edere ọgwụ a n'ọnụ, n'agbanyeghị nri ị ga-eri.

Site n'ọbara mgbali elu, ọgwụ aara aro mbụ bụ 1 mbadamba (40 mg) otu ugboro n'ụbọchị. N'ọnọdụ ebe enweghi ike nweta ọgwụgwọ ọgwụgwọ, ọgwụ ahụ ruru 80mgg otu ugboro n'ụbọchị. Mgbe ị na-ekpebi ma ịbawanye ọgwụ ahụ, ekwesịrị iburu n'uche na mmetụta antihypertensive kachasị na-arụkarị n'ime izu 4-8 mgbe mmalite nke ọgwụgwọ.

Iji belata ọrịa obi na ọrịa, usoro a tụrụ aro ya bụ mbadamba 1 (80 mg) otu ugboro n'ụbọchị. N’oge mmalite ọgwụgwọ, enwere ike ịchọ mgbazi ọbara mgbali elu ọzọ.

Ọrịa ndị ọrịa nwere akụrụ gbasara akwara (gụnyere ndị nọ n'ọbara ha), ndị ọrịa agadi, idozigharị ọgwụ agaghị achọ.

N'ime ndị ọrịa nwere ọrịa imeju na-arụ ọrụ dị nro ma na-agafe agafe (klas A na B n'ihe ọ̀tụ̀tụ̀ nwatakịrị ahụ).

Mmetụta akụkụ

Ọnọdụ ndị a chọpụtara na nsonaazụ ndị ọzọ emetụtaghị na okike, afọ ma ọ bụ agbụrụ ndị ọrịa.

Ọrịa: sepsis, gụnyere egbu egbu, ọrịa urinary tract (gụnyere cystitis), ọrịa akụkụ akụkụ okuku ume na elu.

Site na sistemụ hemopoietic: mbelata hemoglobin, anaemia, eosinophilia, thrombocytopenia.

Site n'akụkụ nke sistemụ akwara: etiti ụra, nchekasị, ịda mba, obi ilu.

Site na usoro akụrụngwa: mbelata akara ọbara mgbali (gụnyere hyịnrịa orthostatic), bradycardia, tachycardia, sua.

Site na sistem iku ume: mkpirisi iku ume.

Site na nri digestive: akpọnwụ akpọnwụ, flatulence, erughị ala na afo, vomiting, dyspepsia, afọ ọsịsa, eriri afọ, ọrụ imeju na - arụ ọrụ, ịba ụba ọrụ nke transmases hepatic.

Site na sistemụ urinary: ọrụ akụrụ na-arụ ọrụ nke ukwuu (gụnyere nnukwu nsogbu gbasara akwara), akụkụ oke, hypercreatininemia.

Site na usoro akwara ahụ: ọrịa ogbu na nkwonkwo, azụ mgbu, olu mgbu (olu nke akwara azụ nke nwa ehi), ihe mgbu na nsọtụ nke ala, myalgia, ihe mgbu na akwara (mgbaàmà yiri ngosipụta nke akwara), obi mgbu.

Mmeghachi omume nfụkasị: mmeghachi omume anaphylactic, mmeghachi omume hyperensiti na-arụ ọrụ ma ọ bụ ihe inyeaka nke ọgwụ ahụ, angioedema, eczema, erythema, itching skin, fash (gụnyere ọgwụ), urticaria, friast toxic.

Ihe ngosi ulo oru: hyperuricemia, mmụba nke ọbara CPK, hyperkalemia.

Ndị ọzọ: hyperhidrosis, ọrịa na-efe efe, nkwarụ anya, asthenia (adịghị ike).

Ojiji nke ọgwụ MIKARDIS® n'oge afọ ime na lactation

Mikardis® bụ nke dị ime n'afọ na n'afọ.

Site na ịtụrụ ime, Mikardis® kwesịrị iji dochie ọgwụ ọzọ. Mgbe etinyere ime, Mikardis kwesịrị ịkwụsị ozugbo o kwere omume.

Na nyocha ndị a kapịrị ọnụ, enweghị ọgwụ teratogenic nke ọgwụ ahụ chọpụtara, mana achọpụtara mmetụta fetotoxic.

Ntụziaka pụrụ iche

Somefọdụ ndị ọrịa, n'ihi nnabata nke RAAS, ọkachasị mgbe ị na-eji ọgwụ ọgwụ ndị na-eme ihe na sistemụ a, arụ ọrụ akụrụngwa (gụnyere nnukwu gbasara akụrụ akwara). Yabụ, usoro ọgwụgwọ a na-ejikọ ọnụ nke abụọ RAAS dị otu a ga-emerịrị kpamkpam n'otu n'otu yana jiri nlezianya na-elele ọrụ gbasara akụrụngwa (gụnyere nlebara anya nke oge ihe yana ihe gbasara protein na creatinine).

N'ihe gbasara ịdabere na olu akwara na ọrụ akụrụ na-arụkarị ọrụ RAAS (dịka ọmụmaatụ, na ndị ọrịa nwere ọrịa obi na-adịghị ala ala, ma ọ bụ ọrịa akụrụ, gụnyere akwara ma ọ bụ stenosis akwara akwara), nhọpụta ọgwụ nke na-emetụta usoro a, enwere ike ijikọ ya na mmepe nke hypotension hypotension, hyperazotemia, oliguria, na, n'oge ụfọdụ, nnukwu ọdịda gbasara akụrụngwa.

Dabere na ahụmịhe nke iji ọgwụ ndị ọzọ na-emetụta RAAS, ya na iji nkwonkwo Mikardis® na ọgwụ na-eme ka nri dịkwuo ụtọ, ihe mgbakwunye potassium, nnu oriri nwere potassium, yana ọgwụ ndị ọzọ na-abawanye mkpokọta potassium na ọbara (dịka ọmụmaatụ, heparin), a ga-enyocha ihe ngosi a na ndị ọrịa.

N'aka ozo, enwere ike iji Mikardis® mee ya na thiazide diuretics, dika hydrochlorothiazide, nke gbakwunyere nwere mmetụta hypotensive (dịka ọmụmaatụ, MikardisPlus® 40 mg / 12.5 mg, 80 mg / 12.5 mg).

N'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba, ọnụọgụ nke telmisartan 160 mg kwa ụbọchị yana njikọta hydrochlorothiazide 12.5-25 mg nke ọma anabatakwa nke ọma.

Mikardis® abaghị uru na ndị ọrịa nke agbụrụ Negroid.

Leasedị mwepụta wepụtara ya

Mpempe usoro onunu ogwu - mbadamba ihe: okirikiri, cylindrical, nke nwere ntụpọ na chamfer, na acha ọcha ma ọ bụ na-acha ọcha-acha odo odo na agba (5, 7, 10 na PC 20.) Na ngwungwu ogbe, na ngwugwu kaadi 1, 2, 3, 4, 5, 8 ma ọ bụ ngwugwu 10, 10, 20, 28, 30, 40, 50, na iberibe otu ọ bụla, na mkpọ nke mbụ ejiri tamper ma ọ bụ ihe eji emegharị ma ọ bụ jiri akara tampa mbụ, na igbe kaadi 1 ngwugwu ọ bụla nwekwara ntuziaka maka ojiji nke Telmisartan).

Ngwakọta 1 mbadamba:

• akụrụngwa arụmọrụ: telmisartan - 40 ma ọ bụ 80 mg,
• ndị mgbe ochie (mbadamba 40/80 mg): silium croscarmellose - 12/24 mg, sodium hydroxide - 3.35 / 6.7 mg, povidone-K25 - 12/24 mg, lactose monohydrate (shuga mmiri ara ehi) - 296.85 / 474.9 mg, magnesium stearate - 3.80 / 6.4 mg, meglumine - 12/24 mg.

Ọbara ọbara

Ojiji nke telmisartan na 80 mg na-egbochi mmetụta hypertensive nke AT II. Mmetụta antihypertensive na-amalite n'ime ihe dị ka awa 3 mgbe ị firstụchara ọgwụ mbụ, na-adịgide ruo awa 24 ma na-adịgide ruo mgbe awa 48. Mmetụta ọgwụgwọ zuru oke na-amalite mgbe izu 4-8 nke iji ọgwụ ahụ eme ihe mgbe niile.

Na ọbara mgbali elu, telmisartan lowers systolic na diastolic ọbara mgbali (BP) na-enweghị emetụta mmetụ obi (HR).

Dis kwụsịchaa ọgwụ ahụ, ọkwa ọbara mgbali laghachiri uru mbụ ọ bara ọtụtụ ụbọchị. Mwepu onwe ya ọrịa anaghị etolite.

Dika ihe omumu ihe omumu, enwere ike idi ire nke telmisartan na ogwu nke klas ndi ozo (dika ọmụmaatụ, atenolol, hydrochlorothiazide, enalapril, lisinopril, amlodipine). Agbanyeghị, ụkwara akọrọ na ndị ọrịa na-anata telmisartan mere ugboro ugboro karịa ndị ọrịa na-ewere ndị na-egbochi ACE.

Mgbochi Ọrịa Obi

N'ime ndị ọrịa afọ iri ise na ise gbagotere n'ọrịa mgbu azụ, ọrịa strok, ọrịa obi na-efe efe (ọnya ịrịa ọnya) na nsogbu nke ọrịa shuga 2 (dị ka hypertrophy aka ekpe, micro- ma ọ bụ macroalbuminuria, retinopathy) na akụkọ ihe mere eme nye ndị otu nọ n'ihe ize ndụ maka ọrịa obi, telmisartan nwere mmetụta yiri nke ramipril iji belata isi okwu ejikọtara: ụlọ ọgwụ n'ihi ọrịa obi na-adịghị ala ala ọrịa ọgbugba nke neostatal, infarction nonyoal nke ọrịa obi, ọnwụ obi.

Egosiwo Telmisartan, nke yiri ramipril, ka ọ dị irè iji belata ugboro ole nke isi ihe: ọrịa strok na-adịghị egbu egbu, infarction myocardial na-adịghị egbu egbu, yana ọnwụ obi.

A mụọbeghị ike nke telmisartan na ọgwụ onunu na-erughị 80 mg iji belata ihe ize ndụ nke ọnwụ obi.

N'adịghị ka ramipril, telmisartan yikarịrị ka ọ ga-akpata nsonaazụ dịka ụkwara akọrọ na angioedema. Agbanyeghị, na ndabere nke ya oriri, akwara ọbara ugboro ugboro mere.

Usoro onunu ogwu:

Otu mbadamba 1 nwere:

onunu ogwu 40 mg

ike ihe: telmisartan - 40 mg

ndị mgbe ochie: sodium hydroxide - 3.4 mg, povidone K 30 (polyvinylpyrrolidone ọkara molekụla arọ) - 12.0 mg, meglumine - 12.0 mg, mannitol - 165.2 mg, magnesium stearate - 2.4 mg, talc - 5.0 mg .

onunu ogwu nke 80 mg

ike ọrụ: telmisartan - 80 mg

ndị na-ebu ụzọ: sodium hydroxide - 6.8 mg, povidone K 30 (polyvinylpyrrolidone ọkara molekụla arọ) - 24.0 mg, meglumine - 24,0 mg, mannitol - 330.4 mg, magnesium stearate - 4.8 mg, talc - 10.0 mg.

Mbadamba nkume ndị ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha, gburugburu, larịị-cylindrical nwere bevel na notch.

Ngwongwo ogwu

Mlọ ọgwụ

Telmisartan bụ angiotensin II receptor antagonist kpọmkwem (ụdị AT₁), dị irè mgbe ejiri ọnụ kwuo ya. Ọ nwere oke mmekọrịta maka AT subtype₁ ndị a na - anabata angiotensin II site na nke a na - achọpụta ihe nke angiotensin II. Na-egosiputa angiotensin nke II site na njikọ ya na onye na-anabata ihe, na-ejighi ihe onye na-atụgharị uche na nnabata a.

Telmisartan na-ejikọ naanị na AT subpepe₁ ndị na-anabata angiotensin II. Njikọ ahụ na-aga n'ihu. Enweghi mmekọrita n’ebe ndị na-anabata ndị ọzọ nọ, gụnyere ọgwụ mgbochi₂ ihe nnabata na ndị ọzọ na - erughi nnabata angiotensin. Ọdịghị uru ọrụ nnabata ndị a bara, yana nsonazụ ha nwere ike ime nke ọma na angiotensin nke abụọ, agụchabeghị nke a na-abawanye na nhọpụta nke telmisartan. Ọ na -ebelata mkpụkọ aldosterone n'ọbara, anaghị egbochi mmiri renin na plasma ọbara ma ọ dịghị egbochi ụzọ ion.Telmisartan anaghị egbochi angiotensin na-agbanwe enzyme (kininase II) (enzyme nke na-akụda bradykinin). Yabụ, atụghị anya mmụba nke mmetụta n'akụkụ bradykinin kpatara.

N'ime ndị ọrịa, telmisartan na ọgwụ nke 80 mg kpamkpam egbochi mmetụta ọbara mgbali nke angiotensin II. A na-ahụ mmalite mmalite nke ọgụ ọgwụ mgbochi n'ime awa 3 mgbe nchịkwa izizi nke telmisartan. Mmetụta ọgwụ ahụ na-adịgide ruo awa 24 ma na-adịgide ruo 48 awa. Nkwupụta ọgwụ akpọrọ na-ebikarị izu 4-8 mgbe nchịkwa ọnụ gachara.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan lowers systolic na ọbara mgbali ọbara (BP) na-enweghị emetụta mmetụ obi (HR).

N'ihe banyere ịkagbu telmisartan na mberede, ọbara mgbali jiri nwayọ laghachi ọkwa mbụ ya na enweghị mmepe nke “nkwụghachi” ahụ.

Mlọ ọgwụ

Mgbe a na -ewere ya okwu ọnụ, a na-etinye ya ngwa ngwa site na eriri afọ. Bioavailability bụ 50%. Mgbe ewere nri n'otu oge, mbelata na AUC (mpaghara n'okpuru oge ịta ahụhụ) sitere na 6% (na kilo 40 mg) na 19% (na dose 160 mg). Mgbe awa atọ a malitesịrị ịbanye na ya, a na-etinye uche gị na plasma ọbara, n'agbanyeghị oge nri. Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. Na_max(ntinye uche kachasị) na AUC dị ihe dị ka ugboro 3 na oge 2, otu, nke kachasị elu na ụmụ nwanyị ma e jiri ya tụnyere ụmụ nwoke na-enweghị nnukwu mmetụta na arụmọrụ.

Nkwukọrịta na protein protein plasma - 99.5%, tumadi na albumin na alfa-1 glycoprotein. Ogo nke ogo ihe pụtara ìhè n’inweta nha anya bụ lita 500. A na-agagharị ya site na conjugation na glucuronic acid. Metabolites anaghị arụ ọrụ ọgwụ. Iwepu ọkara ndụ dị ihe karịrị awa iri abụọ. Ọ nọ n’eriri na - agbanweghi agbanwe, akwara ewepụrụ ya - na - erughi 2% nke ọgwụ a .ụrụ. Mkpochapu plasma dị elu (900 ml / min) ma e jiri ya tụnyere ọbara ọbara “hepatic” (ihe dị ka 1500 ml / min.).

Pharmlọ ọgwụ ọgwụ telmisartan na ndị ọrịa agadi adịghị iche na ndị ọrịa na-eto eto. Dose ukpụhọde adịghị.

Ndị ọrịa nwere akụrụ

Achọghị mgbanwe mgbanwe nke oge a na ndị ọrịa nwere ọrịa akụrụ, gụnyere ndị ọrịa n'ọrịa metụtara akwara ụkwụ. Achọpụghị Telmisartan.

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere ọrịa imeju na-arụ ọrụ dị nro ma na-agafe agafe (klas A na B n'ihe ọ̀tụ̀tụ̀ nwatakịrị ahụ).

Ojiji ụmụaka

Isi ihe ndị na-egosi ọgwụ ọgwụ nke telmisartan na ụmụaka dị afọ 6 ruo 18 mgbe ha gbasachara telmisartan na 1 mg / n'arọ ma ọ bụ 2 mg / n'arọ maka izu anọ, n'ozuzu ya, bụ ihe atụnyere na data enwetara na ọgwụgwọ nke ndị okenye, ma gosipụta na ndị na-abụghị ndị na-ere ọgwụ pharmacokinetics nke telmisartan. tumadi banyere C_max.

Mkparịta ụka ọgwụ ọjọọ

Telmisartan nwere ike iwelie mmetụta hypotensive nke ndị ọrụ antihypertensive ndị ọzọ. Achọpụtaghị ụdị mmekọrịta ndị ọzọ dị mkpa nke ụlọ ọgwụ.

Ihe jikọtara ya na digoxin, warfarin, hydrochlorothiazide, glibenclamide, ibuprofen, paracetamol, simvastatin na amlodipine anaghị eduga na mkparịta ụka dị egwu na ụlọ ọgwụ. Mmụba dị ịrịba ama na nkezi nke digoxin na plasma ọbara site na nkezi 20% (n'otu oge, pasent 39%). Site na nlekọta nke telmisartan na digoxin, ọ bụ ihe amamihe dị na ya ikpebi oge ịhapụ digoxin n'ọbara.

Site na iji telmisartan na ramipril na-eme n'otu oge, a hụrụ mmụba nke okpukpu abụọ na AUC0-24 na Cmax nke ramipril na ramipril. Egosipụtaghi mkpa ogwu di egwu a.

Site na ntinye oge nke ACE inhibitors na njikere lithium, enwere mmụba na-atụgharị atụgharị nke lithium n'ọbara, yana mmetụta nsonaazụ. N'ọnọdụ ndị a na-adịghị ahụkebe, a kọọrọ mgbanwe ndị dị otú ahụ na nchịkwa nke ndị na-anabata angagonensin II antagonist. Site na nhazi nke lithium na angiotensin II antagonist antagonists, a na-atụ aro iji chọpụta mkpo lithium n'ime ọbara.

Ọgwụ na NSAIDs, gụnyere acetylsalicylic acid, ndị na - egbochi COX-2, na NSAIDs na - adịghị ahọrọ, nwere ike ibute nnukwu ọrịa gbasara ndị ọrịa akpịrị. Ọgwụ na-eme ihe na sistemụ renin-angiotensin-aldosterone (RAAS) nwere ike inwe mmetụta synergistic. N'ime ndị ọrịa na-anata NSAIDs na telmisartan, bcc ga-akwụghachi ụgwọ na mbido ọgwụgwọ na ọrụ gbasara akụrụ.

Mbelata mmetụta nke ndị na - egbochi ọgwụ mgbochi, dịka telmisartan, site na mmachi nke mmetụta vasodilating nke prostaglandins ka a hụchara ọgwụgwọ NSAIDs.

Usoro onunu ogwu na nhazi

A na-eche mbadamba Telmisartan maka nchịkwa ọnụ kwa ụbọchị ma were ya mmiri, yana nri ma ọ bụ na-enweghị nri.

Ọgwụ nke ọbara mgbali elu dị mkpa

Ọgwụ okenye a tụrụ aro ya bụ 40 mg otu ugboro kwa ụbọchị.

N'ọnọdụ ebe ọbara na-achọ ihe na-adịghị mma, enwere ike ịbawanye ọnụọgụ nke Telsartan® ruo 80 mg ugboro otu ugboro n'ụbọchị.

Mgbe ị na-abawanye ọgwụ, ekwesịrị iburu n’obi na a ga - enwekarị ọgwụ antihypertensive n’etiti izu anọ ma ọ bụ asatọ mgbe ịmalitere ọgwụgwọ.

Enwere ike iji Telsartan® mee ya na thiazide diuretics, dịka ọmụmaatụ, hydrochlorothiazide, nke jikọtara na telmisartan nwere mmetụta hypotensive ọzọ.

N'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba, ọnụọgụ nke telmisartan bụ 160 mg / ụbọchị (mbadamba abụọ nke Telsartan® 80 mg) yana mgbakwunye hydrochlorothiazide 12.5-25 mg / ụbọchị nke ọma anabata ma dị irè.

Mgbochi ọrịa obi na onwu

Ọgwụ a tụrụ aro bụ mgmita asatọ na otu ugboro kwa ụbọchị.

Ekpebibeghị ya ma usoro ọgwụ dị n'okpuru 80 mg dị irè iji belata ọrịa obi na ọnwụ.

Na nmalite mmalite nke iji ọgwụ ọgwụ Telsartan® maka igbochi ọrịa obi na ọrịa, ọ na-atụ aro ijikwa ọbara mgbali (BP), ọ nwekwara ike ịdị mkpa iji dozie ọbara ọgbụgba na ọgwụ ndị na-ebelata ọbara mgbali elu.

Enwere ike iburu Telsartan® n'agbanyeghị agbanye nri.

Achọghị mgbanwe mgbanwe nke oge a na ndị ọrịa nwere ọrịa akụrụ, gụnyere ndị ọrịa n'ọrịa metụtara akwara ụkwụ. Enweghi ahụmịhe n’ịgwọ ndị ọrịa nwere nnukwu akụrụ gbasara akwara na usoro ịba uru. Maka ndị ọrịa dị otú a, a na-atụ aro ịmalite site na obere ọgwụ nke 20 mg. A naghị ewepụ Telsartan® n'ọbara n'oge ọbara ọgbụgba.

N'ime ndị ọrịa nwere nsogbu imeju dị nro ma ọ bụ nke na-adịghị ala ala, ọgwụ kwa ụbọchị ekwesịghị ịkarị 40 mg otu ugboro n'ụbọchị.

Dose ukpụhọde adịghị.

Nhazi ọkwa nosological (ICD-10)

Emeputa:

Severnaya Zvezda CJSC, Russia

Adreesị iwu nke onye rụpụtara:

111141, Moscow, Zeleny prospekt, d. 5/12, p

Adreesị nrụpụta na nnabata nnabata:

188663, mpaghara Leningrad., Vsevolozhsk district, mmezi ime obodo Kuzmolovsky, ụlọ nke ihe omumu Nke 188

Ime na lactation

Ihe eji eme Telmisartan-SZ bu ihe mgbochi n’oge di ime. Mgbe ịchoputara afọ ime, ekwesịrị ịkwụsị ọgwụ a ozugbo. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịkọwa usoro ọgwụgwọ ọzọ (klas ndị ọzọ nke ọgwụ nje na-akwadoro iji mee n'oge afọ ime).

Usoro nke ARA II n'oge ato nke ato na nke ato di ime.

N'ime ọmụmụ ọmụmụ telmisartan, achọpụtaghị mmetụta teratogenic, mana etinyere fetotoxicity. A maara na ikpughe na ARA II n’oge ọnwa nke abụọ na nke atọ nke afọ ime na-akpata fetotoxicity n’ime mmadụ (mbelata ọrụ gbasara akụrụ, oligohydroamnion, igbu oge nke okpokoro isi), yana nsonye obi na-egbu egbu (ọdịda akụrụ, ọdịda, hyperkalemia). Ekwesịrị inye ndị ọrịa na-eme atụmatụ ịtụrụ ime. Ọ bụrụ na ọgwụgwọ ARA nke Abụọ mere n’oge ọnwa nke abụọ nke ime, a na-atụ aro ka itule ọrụ gbasara akụrụngwa na ọnọdụ nke okpokoro isi nke nwa ebu n’afọ site n’aka ultrasound.

A ga-enyocha ya nke amụrụ ụmụ ọhụrụ nne ha natara ARA nke Abụọ.

Usoro ọgwụgwọ na Telmisartan-SZ bụ contraindicated n'oge ara.

Onweghi nnyocha omumu banyere omumu.