Kedu ihe dị iche na Ramipril na analogues, gịnị nyocha nke ndị ọrịa na-ekwu na otu esi eji dịka ntuziaka ahụ si dị?

Plasma a na-egbochi protein maka ramipril bụ 73%, ramiprilat bụ 56%. Bioavailability mgbe nchịkwa ọnụ nke 2.5-5 mg nke ramipril bụ 15-28%, maka ramiprilat - 45%. Mgbe ị na-ewere ramipril kwa ụbọchị na ọgwụ nke 5 mg / ụbọchị, a na-enweta ọkwa plasma na-adịgide adịgide ramiprilate ụbọchị ruo 4.
T1 / 2 maka ramipril - 5.1 h, na nkesa na mkpochapu usoro, mbelata nke mkpokọta nke ramiprilat n'ọbara ọbara na-apụta na T1 / 2 - 3 h, mgbe ahụ mgbanwe ntụgharị na T1 / 2 - 15 h na-esote, yana ogologo oge ikpeazụ nke nwere ntakịrị ramiprilat ịta. na plasma na T1 / 2 - 4-5 ụbọchị. T1 / 2 na-abawanye na ọdịda akụrụ nwa ada ada. Vd ramipril - 90 l, ramiprilata - 500 l. 60% ka akụrụ napụrụ ya aka, 40% n'ime eriri afọ (ọkachasị n'ụdị metabolites). N'ihe banyere ọrụ ezinaụlọ nwere nsogbu, mwepụ nke ramipril na metabolites ya na-adalata na mbelata na CC, ma ọ bụrụ na arụ ọrụ imeju, ntụgharị gaa ramiprilat na-adalata, ma bụrụ nke obi daa, ntinye uche nke ramiprilat na-abawanye ugboro 1.5-1.8.

Ihe ngosi maka ojiji:
Ihe ngosi maka iji ogwu Ramipril bụ: ọbara mgbali elu, nkụchi obi na-adịghị ala ala, nkụchi obi nke bidoro n’ime ụbọchị mbụ ndị mbụ gbasara ọrịa infịction myocardial infarction, ọrịa shuga na nondiabetic nephropathy, mbelata nke ọrịa myocardial infarction, ọrịa strok na ọnwụ obi na ndị ọrịa nwere nnukwu ọrịa obi, gụnyere ndị ọrịa nwere nkwarụ akwara na - arịa ọrịa obi (nke nwere nkụchi obi ma ọ bụ nke na - enweghị), ndị ọrịa na - agbagha transluminal coronary angioplasty, ịwa ahụ na-agafe, na insulin. na akụkọ ihe mere eme na na ọrịa na elu ọbara occlusive ọrịa.

Ofzọ nke ngwa

Ọgwụ Ramipril were ọnụ, ya na ọbara mgbali elu - ọgwụ mbụ - 2.5 mg otu ugboro n’ụbọchị, yana ogologo oge ọgwụgwọ - 2.5–20 mg / ụbọchị n’ime 1-2. Site na nkụchi obi na oge mmerụ ahụ, na mbido mbụ nke 2.5 mg ugboro abụọ kwa ụbọchị, ma ọ bụrụ na enweghi ike - 5 mg ugboro abụọ kwa ụbọchị, yana nnukwu hypotension ma ọ bụ megide ndabere nke diuretics - 1.25 mg ugboro abụọ kwa ụbọchị. Na ọdịda akụrụngwa (mmụba ụwa na-erughị 40 ml / min na ọkwa creatinine karịa 0.22 mmol / l), usoro izizi bụ 1/4 nke oge a na-eji mmụba nwayọọ nwayọọ ruo 5 mg / ụbọchị (ọ dịghị ihe ọzọ).

Nsonaazụ

Site na usoro akwara obi: hypotension arterial, nke adịkarịghị - mgbu obi, tachycardia.
Site n'akụkụ nke sistemụ etiti: ọgbụgbọ, adịghị ike, isi ọwụwa, adịkarịghị - nsogbu aghara ụra, ọnọdụ uche.
Site na usoro nri: afọ ọsịsa, afọ ntachi, agụụ, na - adịkarịghị - stomatitis, mgbu nke afọ, pancreatitis, cholestatic jaundice.
Site na sistem iku ume: ụkwara na-egbu, ụkwara akwara, sinusitis.
Site na usoro urinary: adịkarịghị - proteinuria, mmụba na mkpokọta nke creatinine na urea n'ọbara (tumadi na ndị ọrịa nwere ọrụ mkpo ya arụ ọrụ).
Site na sistemụ hemopoietic: adịkarịghị - neutropenia, agranulocytosis, thrombocytopenia, anaemia.
N'akụkụ nke ihe ngosipụta ụlọ nyocha: hypokalemia, hyponatremia.
Mmeghachi omume nfụkasị: nfụkasị anụ ahụ, angioedema na mmeghachi hyperensitivity ndị ọzọ.
Ndị ọzọ: adịkarịghị - nju ike, enweghi ike, alopecia.

Ihe ngbanwe

Ihe mgbochi igbochi iji ogwu Ramipril bụ: nsogbu gbasara akụrụ na ọrịa ịba ọcha n'anya, akwara azụ akwara akwara ma ọ bụ stenosis nke otu akụrụ akwara, ọnọdụ mgbe akụrụ, akwara hyperaldosteronism, hyperkalemia, stenosis nke aortic orifice, ịtụ ime, lactation (inye ara), ụmụaka na umuaka n’agbata afọ 18, na-abawanye mmetụta uche na ramipril na ndị ọzọ ACE inhibitors.

Mmekọrịta na ọgwụ ndị ọzọ

N'iji oge a na - ejikọ potassium-sparing diuretics (gụnyere spironolactone, triamteren, amiloride), nkwado potassium, nnọchi nnu na mgbakwunye nri maka nri nwere potassium, hyperkalemia nwere ike ịmalite (ọkachasị ndị ọrịa nwere ọrụ mgbazinye nsogbu). Ndị na - egbochi ACE na --ebelata ọdịnaya nke aldosterone, nke na - eduga na igbu oge na potassium n'ime ahụ megide ihe na - egbochi ịmịcha nke potassium ma ọ bụ ihe ndị ọzọ ọ na - ewe.
Site na iji NSAID mee ihe n'otu oge, ọ ga-ekwe omume belata mmetụta antihypertensive nke ramipril, arụ ọrụ ezumike arụ ọrụ.
N'iji loop ma ọ bụ thiazide diuretics, na-eme ka mmetụta antihypertensive dịkwuo mma. Nnukwu ọgbụgba akwara ike, karịsịa mgbe ị theụchara ọgwụ mbụ diuretic, pụtara na hypovolemia, nke na-eduga n'ịba ụba nwa oge na mmetụta hyperensive nke ramipril. Enwere ihe ize ndụ nke hypokalemia. Riskbawanye n'ihe egwu na arụ ọrụ na arụ ọrụ.
N'iji oge a na-eji ndị nnọchi anya nwere mmetụta hypotensive, mmụba na mmetụta hypotensive bụ omume.
N'iji immunosuppressants na-eme n'otu oge, cystostatics, allopurinol, procainamide, enwere ohere dị ukwuu nke ịmalite leukopenia.
N'iji insulin na-eme n'otu oge, ndị na-ahụ maka hypoglycemic, sulfonylureas, metformin, hypoglycemia nwere ike ịmalite.
Site n'iji allopurinol, cystostatics, immunosuppressants, procainamide, na-emewanye ohere nke ịmalite leukopenia.
N'iji carbonate lithium mee ihe n'otu oge, mmụba nke oghere lithium ga-ekwe omume.

Dodoụbiga ya ókè

Ihe mgbaàmà nke oke ị ofụ ọgwụ Ramipril: nnukwu akwara hypotension, ọrịa mberede ụbụrụ, ọrịa angioedema, infarction myocardial, nsogbu nke thromboembolic.
Ọgwụ: Mbelata dose ma ọ bụ nkwụghachi ọgwụ zuru ezu, lavage gastric, na-eme ka onye ọrịa nọrọ n'ọnọdụ dị larịị, na-ewere usoro iji mee ka BCC dị elu (na-edozi isotonic sodium chloride solution, mmịnye nke mmiri ndị ọzọ na-eji dochie ọbara), ọgwụgwọ Symptomatic: epinephrine (s / c ma ọ bụ iv), hydrocortisone (iv), antihistamines.

Ramipril - ihe na-arụ ọrụ

Mmetụta ahụ na-ekpebi ihe dị ike na mejupụtara ya. Mbadamba ụrọ Ramipril na-arụ ọrụ n'ihi isi ihe mebere - ramipril.

Tebụl 1. Ihe dị Ramipril na-arụ ọrụ na nsonaazụ o nwere.

Kedu ihe kpatara ọgwụ eji eji ramipril eme ihe?

Ogwu Ramipril eweputala onwe ya dika ogwu di elu ma di nma. Karịsịa, a na-eji ọgwụ ahụ eme ihe maka:

1. Ọbara mgbali elu. Ngwá ọrụ ahụ, dị ka ntuziaka ahụ si dị, enyere iwu iji mepụta ebumnuche nke systolic na nrụgide diastolic.
2. Usoro ọgwụgwọ nke ọrịa obi ọsịsọ. Otu esi ewere mbadamba Ramipril, ihe na ihe ọ ga-eme ya dabere na ọrịa ahụ.
3. Carmechi mgbochi nke ọrịa obi na akwara ọbara n’ịchọpụta ihe egwu dị.
4. Mgbochi ọnwụ n'ihi ọrịa obi.

Mwepụta wepụtara ya na ihe mejupụtara

Ngwá ọrụ dị na ndabere nke otu ihe eji arụ ọrụ. Nkwekorita, nnabata ya na ndu ogologo ndu na - ebute ihe ndi ozo.

Dabere na ntuziaka maka ojiji, ọgwụ Ramipril nwekwara:

1. Lactose n'efu. A na-akpọkwa ihe a na-akpọ shuga mmiri ara ehi. Ejiri dị ka nzacha nke njikere mbadamba, ọ bụ ihe ọzọ na-enye ike.
2. Povidone. Na-ezo aka na enterosorbents, na-akwalite mwepụta nke ihe ahụ na-arụ ọrụ.
3. Cellulose Ejiri ya n'ụdị microcrystalline ntụ ntụ, na-enye ohere mbadamba ahụ ka ọ nọgide na-enwe ọdịdị ya.
4. Stearic acid. Acid ajuju juru eju, emulsifier na stabilizer.
5. Crospovidone. Na-akwalite mwepụta na nnabata nke ihe na-arụ ọrụ.
6. Sodium bicarbonate. A maara dị ka mmiri soda, ọ bụ ihe a na-eme ka ọ kwụsie ike.

Ramipril (mpempe ntọhapụ - naanị mbadamba) dị na usoro ndị a:

1. 2,5 mg Mpempe akwụkwọ ọcha / ihe fọrọ nke nta ka ọ bụrụ ọcha, juputara na blisters na igbe kaadiboodu. Ibe 10, 14 ma ọ bụ mkpụrụ ego 28.
2. Ramipril 5 mg. Mbadamba akwụkwọ ọcha / nke na-acha ọcha. Na iberibe 10/14/28. A na-akwakọba blister na igbe kaadi. Otu obula nwere ntuziaka maka ojiji.
3. Ramipril 10 mg. Ha nwere ajị ọcha / nke dịkarịsịrị ọcha. Mbadamba ụrọ dị na blisters maka mbadamba 10/14/28. Erere na kaadiboodu tinyere ntuziaka maka ojiji.

Ramipril, usoro ọgwụgwọ nke onye ọkachamara kpebisiri ike, bụ ọgwụ.

Ramipril-sz

Ramipril-SZ na Ramipril bụ nkọwa. Ebe anyị nyochachara ntuziaka maka ojiji ọgwụ abụọ a, anyị nwere ike ikwubi na ihe mejupụtara ya bụ otu ihe ma nwee otu mmetụta.

Nyocha ndị ọrịa na-akacha mma. Akpan akpan:

1. Mbadamba ụrọ sitere na nrụgide Ramipril nwere mmetụta ngwa ngwa. Dabere na ntuziaka maka ojiji, mgbe naanị minit 15 gasịrị, ọnọdụ onye ọrịa amalitela mma.
2. Mmetụta oge. Ebumnuche na-adịgide ruo awa 12 ruo 24.
3. Mgbe ị na-ede akwụkwọ, enwere nkwalite ahụike na ogo ndụ niile.
4. Nsonaazụ ndị a na-adịghị ahụkebe na-adịkarị obere ma nwee ọdịdị dị nro.

Ngwaahịa ọzọ mmekọrịta nke ewepụtara n’okpuru aha ahia dị iche. Pyramil na Ramipril, ihe mejupụtara nke dị iche na ụfọdụ ihe inyeaka, bụ ọgwụ na-agbanwe agbanwe. Ọgwụ na-egosi nsonaazụ dị mma na ọgwụgwọ ọbara mgbali elu. Ọ na-akwadoro maka:

• ụdị ọrịa obi na-egbu afọ mgbu,
• Ọrịa obi na-adịghị ala ala,
• nephropathy kpatara ọrịa shuga,
• na ọrịa vaskụla (ọrịa strok, ọrịa),
• maka igbochi oria ufodu na onwu site na ha.

Ihe omuma zuru ezu banyere ihe Pyramil bu, otu esi ewere ya nke oma, na ebe amachibidoro ya, enwere ntuziaka maka ojiji.

Ọgwụ mara mma a na-eji agwọ ọtụtụ ọnọdụ. Ọ nwere mmetụta mmekọrịta na mejupụtara ya. Dika nyocha emere na 1990s, nrụgide dị mma karịa ọtụtụ ọgwụ ndị ọzọ (dịka ọmụmaatụ, enalapril). Ihe ọghọm dị na Hartil gụnyere ọnụahịa ya. Na nkezi, ọgwụ ahụ ga-eri ọnụ ego okpukpu 3-4 karịa ọnụ karịa Ramipril (ihe ndị na-egosi maka iji ego bụ otu). Amachibidoro:

• planningmụ nwanyị na-eme atụmatụ ime, dị ime ma ọ bụ ndị nọọsụ,
• ụmụaka na ndị na-eto eto nọ n’agbata afọ 18.

Ndị ọrịa gafere afọ 65 kwesịrị iji nlezianya kpachara anya Hartil. Erere nke mbu kwesiri ị drunku mmanya n’okpuru nlekọta nke otu ọkachamara.

Ọ bụ usoro agbalite ọgwụ. Nsonaazụ pụtakwuru bụ n'ihi ọnụnọ n'ụdị akwara - hydrochlorothiazide. Ihe ahụ na-enyere aka belata ọbara mgbali elu na ntakịrị mmụba na diuresis.

Dabere na ntuziaka maka ojiji, a na-atụ aro ọgwụ ahụ maka ndị ọrịa na-enweghị ọgwụ ACE inhibitor monotherapy. Iji rụpụta nsonaazụ amara, a na-enye usoro nchịkwa nke Hartila-D.

Kedu onye na-emepụta ọgwụ mbụ?

Enwere ọtụtụ ụdị na-emepụta ọgwụ na otu ihe mejupụtara, mana n'okpuru aha dị iche iche. Ramipril bụ ọgwụ mbụ mepụtara na Russia. Companylọ ọrụ na-emepụta ọgwụ Tatkhimpharmpreparaty dị na Kazan wee na-arụ ọrụ kemgbe afọ 85. Companylọ ọrụ ahụ na-emepụta ọgwụ karịrị narị 100 ma na-ekwe nkwa nchekwa ngwaahịa. Na weebụsaịtị ụlọ ọrụ ị nwere ike ịchọta ntuziaka zuru oke maka ojiji.

Ihe ngosi maka ojiji

Ngwọta ọgwụ Ramipril, ntuziaka maka ojiji nke nwere ndepụta zuru ezu iji gosipụta ya, ka enyere ya ma nyocha ya ma nchọpụta ya. Ngwa akwadoro maka:

1. Ọbara ọbara. Ramipril na-enyere aka belata nrụgide n'ụdị ọrịa ahụ, nke biliri iche na ọrịa ndị ọzọ. Ọ dịkwa mma maka ọbara mgbali elu nke kpatara nsogbu nke sistem.
2. Ọrịa obi na-adịghị ala ala. A na-eji ya dị ka akụkụ nke ọgwụgwọ njikọta.
3. Ọrịa obi na akwara obi, gụnyere ọrịa myocardial infarction.
4. Duct na-eme ọgwụgwọ na ndị ọrịa lanarịrị ịwa ahụ (ịwa ahụ, angioplasty, wdg).
5. Ndị ọrịa na-arịa ọnya akwara, tinyere akụkọ banyere ọrịa strok.
6. Na -eme ka mgbochi nke ọrịa na - arịa ọbara na obi, gbochie ọnwụ.
7. Ọrịa shuga agbagha.

Kedu ihe na-ekpebi ọbara mgbali mmadụ

Ntụziaka maka ojiji

Tupu ị theụ ọgwụ ahụ, ị ​​ga-amata onwe gị na ndụmọdụ nke onye nrụpụta. Ntuziaka maka iji ya nwere ndepụta nke ihe gbochiri ị takingụ ọgwụ. Ya bụ:

1. Ọrịa ọnya na-emetụta akwara njikọ (lupus erythematosus, scleroderma).
2. Anabataghị Onye ọ bụla n’ime ihe mejupụtara ya, gụnyere ị laụ lactose adịghị mma.
3. Nchọpụta ọnya Quincke edema ma ọ bụ edepụtara Quincke na - apụta na mbido mgbe iwere ego dabere na ramipril.
4. Ọrịa hypotonic.
5. Imeju ma ọ bụ arụ ọrụ akụrụ arụ.
6. Stenosis nke otu akụrụ / akwara akwara, nwere ịwa ahụ akụrụ.
7. Decompensated obi ida.
8. Nchịkọta gabigara ókè nke aldosterone.
9. Jiri na ndị ọrịa na-arịa ọrịa shuga na-anata aliskeren na ndị ọzọ.

A na-egosi ndepụta ahụ dum na ntuziaka maka ojiji. Echefukwala ị gụpụta nkọwa ahụ tupu ị medicalụ ọgwụ.

Ọnụ ego ọgwụ ahụ dabere na ọrịa ugbu a.

Tebụl 2. Usoro ọgwụgwọ Ramipril dị nso maka ọrịa dị iche iche.

Dika ihe omumu ohuru na ntuziaka maka ojiji, ogwu kwesiri ịmalite ihe omuma ya na 1.25 mg kwa ubochi. Agbanyeghị, ọ bụ dọkịta na-eme mkpebi gbasara otu onye ọrịa. Egosiputara usoro zuru ezu na nkọwapụta.

Mmanya ndakọrịta

Agaghị agwakọta ọgwụ ahụ na mmanya maka ihe ụfọdụ:

1. Mmanya na-eduga ná mmetụta gabigara ókè nke ọgwụ ahụ. Ibelata ọbara mgbali elu nwere ike ibute nnukwu nsogbu ma ọ bụ ọ nwụọ onye ọrịa.
2. Xicụ mmanya na-egbu egbu. Ọgwụ na ethanol na-emerụ ahụ, na-eme ka ihe ka njọ, na-eduga n'ọrịa dị iche iche.

Nyocha nke ndị ọrịa na-a medicineụ ọgwụ maka nsogbu

Echiche nke ndị ọrụ na ntanetị ekwesịghị ịbụ ihe nkatọ maka ịlele ọgwụ. Nhọrọ nke ọgwụ bụ kpamkpam onye. Ramipril, nyocha nke nwere data na-emegiderịta onwe ha, ka akwadoro maka:

• ọsọ nke ihe
• ogologo oge mmetụta
• enwere ike ị nweta otu ọgwụ,
• ọnụahịa dị mma
• ohere ịzụta n'ụlọ ahịa ọgwụ ọ bụla.

Ndị ọrịa ndị ọzọ na-akọ na ọgwụ ahụ enweghị mmetụta ọ bụla achọrọ mgbe nchịkwa ma ọ bụ bute nsonaazụ. Ọtụtụ mgbe ndị mmadụ na-eme mkpesa banyere:

• ụkwara na-egbu mgbu,
• njọ na ndụ mmekọahụ,
• amata aja aja.

Ntụziaka Latin

A na - emepụta ọtụtụ ụlọ ọrụ Ramipril (esi eme nri na Latin - Tab. Ramiprili). Decdị ọgbaghara a ga - enyere gị aka ịkọwa otu ngwa ọrụ ọbụladị n'okpuru aha azụmaahịa dị iche iche. Agbanyeghị, ịzụta ọgwụ na-enweghị nkwenye nke ọkachamara adịghị mma.

E nwere ọtụtụ ọgwụ ndị ọzọ nwere ụdị ọgwụgwọ ahụ. Ramipril, analogues nke ndị a na-anọchite anya ya, ka enwere ike dochie ya site na nkwekọrịta ya na dọkịta.

Ideringtụle Ramipril na Enalapril, nke ka sie ike ikwu n'eziokwu. Ogwu nwere otutu iche:

1. Ihe eji arụ ọrụ. Ngwakọta ọrụ nke na-arụ ọrụ na nchịkọta nke enalapril bụ enalapril.
2. A na-ele Enalapril anya dị ka ọgwụ na-adịghị ike, mana echiche a bụ nke ọ bụla. N'ime ndị ọrịa dị iche iche, ihe ga-esi na ya pụta nwere ike bụrụ nke ọzọ.
3. Efu. Enalapril dị ọnụ ala karịa ọgwụ analogue.

Lisinopril

Dika ihe omumu ihe omumu nke mba uwa site n’aka NORA, Lisinopril abughi nke oma karie ka analog ya.

N'iburu n'uche Ramipril na Lisinopril, nke ka mma ma dịkwuo irè, ndị ọkà mmụta sayensị kwubiri na ọgwụ mbụ nwere ike melite ogo na ndụ mmadụ nke onye ọrịa nwere ọrịa obi na ọrịa obi. Ọmụmụ ihe ahụ metụtara puku mmadụ iri.

Perindopril

Ejiri Perindopril nwere mmetụta na-adịghị ike hypotensive, nke a bụ eziokwu karịsịa maka ọgwụ mbụ. A na-atụ aro ịhọpụta ya n'ọnọdụ ụkọ ọbara na-adịghị ala ala. Ọtụtụ mgbe, a na-eji ya dị ka akụkụ nke ọgwụgwọ ọgwụgwọ yana yana diuretics. Tụnyere Ramipril na Perindopril, nke ka mma ma dị irè karị, ọtụtụ ndị dọkịta na-achọ ọgwụgwọ mbụ. Agbanyeghị, mkpebi ikpeazụ na-adabere na ikpe ahụ akọwapụtara.