Tulip 10

Sdị usoro onunu ogwu - mbadamba ihe nkiri: 10 mg - ọcha ma ọ bụ nke na - acha ọcha mkpuchi, HLA 10 na-ese ihe n'otu akụkụ, 20 mg ìhè mkpuchi odo na-acha odo odo, HLA 20 na-ese n'otu akụkụ, 40 mg - ihe nkiri na-acha ọcha nwere agba agba aja aja na-acha odo odo, nke na-egosi ihe nkiri n'otu akụkụ, “HLA 40” na-ese ihe, mbadamba biconvex, okirikiri, nkebi - ọcha (pcs iri na abụọ na blisters, na mkpọ nke kaadiboodu 3, 6, 9 blisters).

Ngwakọta 1 mbadamba:

• ihe na-arụ ọrụ: atorvastatin (n'ụdị calcium atorvastatin) - 10, 20 ma ọ bụ 40 mg,
• ngwa inye aka: sodium croscarmellose, lactose monohydrate, polysorbate 80, hyprolose, colloidal silicon dioxide, magnesium stearate, magnesium oxide, microcrystalline cellulose,
• kootu ihe nkiri: hyprolose, hypromellose, macrogol 6000, talc, titanium dioxide, maka ogwu nke 20 na 40 mg, na mgbakwunye, iron oxide bụ odo.

Ihe ngosi maka ojiji

• hypercholesterolemia bụ isi, heterozygous ezinụlọ na hypercholesterolemia na-abụghị ezinụlọ na jikọtara ọnụ (agwakọta) ụdị IIa na IIb hyperlipidemia dị ka usoro nke Fredrickson - A na-eji Tulip na nri hypocholesterolemic mee ihe iji belata oke nchịkọta nke cholesterol zuru oke (Chc), ntakịrị density lirol B (apoV), thyroglobulin (TG), na ịba ụba nke ịba ụba lipoprotein cholesterol (HDL-C), mgbe naanị usoro ọgwụgwọ nri na usoro ndị ọzọ na-abụghị ọgwụ. ha enwechaghị mmetụta
• Hyzycholesterolemia nke homozygous - iji belata oke elu nke LDL-C na cholesterol zuru oke, mgbe naanị usoro ọgwụgwọ nri na ụzọ ndị ọzọ na-abụghị ọgwụ siri ike,
• nsogbu nke akwara obi na ndị ọrịa na-enweghị ihe ngosipụta akwara nke ọrịa obi obi (CHD), mana ọnụnọ ụfọdụ ihe ọghọm maka mmepe ya, dị ka ihe nicotine riri ahụ, ọbara mgbali elu, retinopathy, ọrịa shuga mellitus, albuminuria, plasma pere mpe nke HDL-C, mkpụrụ ndụ ihe nketa. nsogbu, gụnyere ihe gbasara mmalite nke dyslipidemia, afọ karịrị afọ 55 - maka mgbochi mbụ,
• Ọrịa obi na-arịa ndị ọrịa nwere akwara mkpụrụ obi - prophylaxis nke ọnọdụ iji belata ọnụ ọgụgụ ndị na - anwụ, ọnya, infarction myocardial, ịmalite ụlọ ọgwụ maka angina pectoris na mkpa nke ịmụgharị.

Ihe ngbanwe

• mmebi imeju na-arụ ọrụ,
• mmụba na ọrụ plasma nke hepatic transaminases nke amabeghị ma e jiri ya tụnyere njedebe dị elu nke nkịtị (VGN) karịa ugboro atọ,
• Ọrịa glucose-galactose malabsorption syndrome, ekweghị ekwe lactose, ụkọ lactase (gụnyere lactose),
• afọ ime na oge ị breastụ nwa ara,
• umuaka na umuaka noo n’agbata afọ iri na asatọ (ike na nchekwa nke iwere atorvastatin n’ime ọgbọ ndị ọrịa a).
• mụbaa mmetụta uche ndị dị na ọgwụ ahụ.

N'iji nlezianya mee ihe, a na-eji Tulip mee ihe n'ọnọdụ enweghị oke elektrọnte electrolyte, akụkọ banyere ọrịa imeju, ị alcoholụbiga mmanya ókè, ọrịa akwara na akụkọ ihe mere eme nke usoro akwara n'ihi ojiji nke ọgwụ ndị ọzọ nke otu nke HMG-CoA reductase inhibitors, metabolic and endocrine (hyperthyroidism) ) nkwarụ, hypotension akwara, ọrịa shuga, nnukwu ọrịa na-efe efe (sepsis), ọrịa na-achịkwaghị achịkwa, nnukwu ịwa ahụ, trauma, lipid na-eme ihe ike. na -ebelata usoro ọgwụgwọ (atorvastatin na dose 80 mg) maka mgbochi nke abụọ na ọrịa strok na ndị ọrịa nwere akụkọ banyere ọbara ọgbụgba ma ọ bụ ọrịa mkpụrụ ndụ.

Usoro onunu ogwu na nhazi

Tupu ịmalite iji ọgwụ Tulip ọgwụ, onye ọrịa ahụ kwesịrị ịkwado usoro nri hypocholesterolemic, nke a ga-ahụrịrị n'oge ọgwụgwọ niile nke ọgwụ ahụ.

Mbadamba ụrọ na-ewere okwu ọnụ, n'agbanyeghị nri.

Usoro a na-atụ aro ka usoro ọgwụ kwa ụbọchị nke Tulip bụ 1080 mg, a na-ahọrọ ọgwụ ụfọdụ dabere na ntinye uche nke LDL-C, ebumnuche ọgwụgwọ na nzaghachi ọgwụgwọ nke onye ọrịa ahụ.

Ọgwụ nke mbụ n'ọtụtụ oge bụ 10 mg kwa ụbọchị, kachasị - 80 mg kwa ụbọchị.

Na nmalite ọgwụgwọ, mgbe mkpụrụ ụbọchị iri na anọ gafere iri abụọ na asaa na / ma ọ bụ mmụba ọ bụla na ọgwụ ahụ, a ga-enyocha ike itinye uru nke egbugbere ọnụ plasma ma, ọ bụrụ na ọ dị mkpa, ekwesịrị idozigharị ọnyarị nke atorvastatin.

Usoro a tụrụ aro:

• isi (heterozygous hereditary na polygenic) hypercholesterolemia (ụdị IIa) na ngwakọta hyperlipidemia (ụdị IIb): a na-etinye 10 mg otu ugboro kwa ụbọchị zuru ezu (enwere ike iji 10 na mbadamba 20 mg), ma ọ bụrụ na ọ dị mkpa, jiri nwayọọ nwayọọ mụbaa ọgwụ ahụ ruo 80 mg (2 mbadamba 40 mg), n’iburu n’obi ihe onye ọrịa na-aza ma na-elele oge dị n’etiti ịrị elu nke ụbọchị 14–28, n’ihi na a na-ahụ na a na-ahụ ọgwụgwọ ahụ ka ụbọchị 14 gachara, a na-edekwa nsonaazụ ọgwụgwọ kachasị mgbe ụbọchị 28 gachara ma dịgide ogologo oge l. obe
• Hyzycholesterolemia homozygous hereditary: 80 mg (mbadamba abụọ nke 40 mg) 1 oge kwa ụbọchị,
• Ọrịa obi (maka prophylaxis): 10 mg otu ugboro n'ụbọchị, ọ bụrụ na eruteghị ọkwa plasma nke LDL, ọ ga-ekwe omume iji nwayọ bulie ọgwụ ahụ ka ọ bụrụ 80 mg (mbadamba abụọ nke 40 mg), na-eburu n'uche ihe onye ọrịa na-elele ma na-elele oge dị n'etiti mmụba nke 14 –28 ụbọchị.

Onweghi mmezi ogwu nke Tulip choro maka ndi oria na ezughi oke gbasara ya na ndi agadi.

Site na ọrụ imeju na - arụ ọrụ, iwepụ atorvastatin n'ahụ ahụ na - agbada, n'ihi ya a na - atụ aro iji ya kpachara anya, na - elele ọrụ mgbe niile ọrịa hepatic transminases: aspartate aminotransferase (ACT) na alanine aminotransferase (ALT).

Nsonaazụ

• sistemu ụjọ: mgbe ụfọdụ - isi ọwụwa, ugboro ugboro - nsogbu ịrahụ ụra (gụnyere ehighị ụra na ụra abalị), dizzness, asthenic syndrome, paresthesia, hypesthesia, adịghị ike, ncheta / mfu, na-enwe mmetụta nke uto, na - adịkarịghị - neuropathy na - agbatị,
• akụkụ anụ ahụ: anụ ahụ ọhụhụ, tinnitus, ọ na - adịkarịghị ike ọhụụ, anya na - anụ ntị,
• sistemụ nri nri: oge ​​- flatulence, afọ ntachi, ọgbụgbọ, dyspepsia, afọ ọsịsa, infrequently - ọgbụgba, anorexia, ịba ọcha n'anya, pancreatitis, belching, mgbu afọ, adịkarịghị - cholestatic jaundice (gụnyere mgbochi), adịkarịghị - imeju imeju,
• usoro akwara: mgbe mgbe - ọzịza nke nkwonkwo, myalgia, ọrịa ogbu na nkwonkwo, mgbu nkwonkwo, olu spasm, azụ mgbu, ugboro ugboro - mgbu olu olu, myasthenia gravis, adịkarịghị myositis, myopathy, rhabdomyolysis, tendinopathy (mgbe ụfọdụ tupu akwara na-akụ mmụọ), oge na-enweghị njedebe - nke ikpe na-egbochi ọgbụgba myopathy,
• anụ ahụ na ọnya subcutaneous: ugboro ugboro - ọnya ọnya, itching, urticaria, alopecia, na - adịkarịghị - oke njo, angioedema, erythema multiforme (gụnyere ọrịa Stevens-Johnson syndrome) yana ọrịa Lyell (nrịba nke necrolysis na-egbu egbu),
• sistem hematopoietic: nwa oge - thrombocytopenia,
• metabolism: ọtụtụ mgbe - hyperglycemia, ugboro ugboro - hypoglycemia,
• usoro iku ume: mgbe mgbe - akpịrị mgbu, nasopharyngitis, imi,
• sistemu na - alụso ọrịa ọgụ: ọtụtụ mgbe - mmeghachi omume hypersensitivity, nke adịkarịghị - anaphylaxis,
• ndị na-egosi ụlọ nyocha: ọtụtụ mgbe - mmụba na ọrụ nke serum creatine phosphokinase (CPK), mmụba na ọrụ nke AlT na AST, ugboro ugboro - leukocyturia, ugboro ugboro - mmụba na mkpokọta nke gemocosylated haemoglobin,
• mmeghachi omume ndị ọzọ: adịghị ike - ịba ụba ike ọgwụgwụ, ọdịda nke obere ụlọ, nsogbu na-adịghị ala ala, hyperthermia, oke ọgụ, obi mgbu, oke ibu, dịkarịsịrị - ọrịa shuga mellitus, gynecomastia, enwere ụfọdụ data na mmepe nke atonic fasciitis, mana ezigbo njikọ na ojiji nke atorvastatin abụghị guzosiri ike, oge a na-ejighi n'aka - ọrịa ọrịa ngụgụ (ọkachasị na iji ogologo oge), ịda mba, dysfunction mmekọahụ.

N'ihe banyere njupụta nke Tulip, ọ dị mkpa ịgwọ ọrịa Symptomatic. Atorvastatin enweghị ọgwụ mgbochi akọwapụtara, yana ịba ọcha n'anya adịghị nke ọma n'ihi njikọkọ ọgwụ dị ukwuu na protein plasma ọbara.

Ntụziaka pụrụ iche

Tulip, dị ka statins ndị ọzọ (HMG-CoA reductase inhibitors), nwere ike iwelie ọrụ ọbara nke enzymes imeju ACT na ALT karịa ugboro atọ ma e jiri ya tụnyere VGN. Yabụ, achọrọ ka ọ nyochaa ndị ọrụ na-egosi ọrụ imeju tupu iwere ọgwụ ahụ, mgbe izu isii na iri na abụọ site na mbido ọgwụgwọ yana mmụba na ọnụọgụ ya. Ọ dịkwa mkpa ileba anya na ihe mmadụ na-achọpụta imeju ya mgbe ihe ngosipụta nke ọnya na-apụta. Site na ọrụ na-abawanye nke ACT na ALT, a ga-enyocha ndị na-egosi ihe ruo mgbe ụkpụrụ ga-agbanwe, ma ọ bụrụ na mmụba ahụ dị elu karịa okpukpu atọ karịa VGN ma na-adịgide, a na-atụ aro ka ibelata dose ma ọ bụ kwụsị ị theụ ọgwụ ahụ.

Ojiji ọgwụ Tulip nwere ike ibute mmepe nke myalgia. N'ime ndị ọrịa nwere mgbasa myalgia, adịghị ike ma ọ bụ mgbu na / ma ọ bụ mmụba dị ịrịba ama na ọrụ CPK, enwere ike ịtụ aro myopathy. N'okwu a (ọnụnọ nke enwetara / myopathy na-enyo enyo), ekwesịrị ịkwụsị ọgwụ nke atorvastatin.

N'ihi ịba ụba nke myopathy na iji otu oge nke tulip nwere immunosuppressants, fibrates, ọgwụ azole antifungal, erythromycin, nicotinic acid (na mkpo ala nke ihe karịrị 1 g kwa ụbọchị), a na-amalite ọgwụgwọ ọgwụ naanị mgbe ejiri nlezianya nyocha nke oke nke elele anya na-emetụta ọgwụgwọ n'akụkụ ahụ. mmeghachi omume. Ọ bụrụ na ọ dị mkpa, a na-atụ aro ọgwụgwọ dị iche iche ịtụle ohere nke mgbazi mbụ na mmezi nke ọgwụ ndị a n'ụzọ nke mbelata.

N'oge usoro ọgwụgwọ, a ga-enyocha ihe omume CPK na ndọpụ ọbara glucose kwa oge.

Ekwesịrị ịgwa ndị ọrịa banyere mkpa ịgakwuru dọkịta ozugbo ma ọ bụrụ na mgbu na-enweghị ịkọwapụta na / ma ọ bụ adịghị ike na-egosi, nke kachasị njọ yana ahụ ọkụ.

Ekpesara ikpe nke rhabdomyolysis na mmepe nke nnukwu akwara ọdịda n'ihi myoglobinuria n'ihi iji ọgwụ Tulip, yana statins ndị ọzọ (HMG-CoA reductase inhibitors).

Ọ bụrụ na enwere ihe mgbaàmà nke myopathy enwere ike ma ọ bụ ihe ize ndụ nke ịmalite nsogbu ọdịda akwara (akwara hypotension, nnukwu ọrịa, trauma, oke ịwa ahụ, nnukwu metabolic, endocrine na electrolyte ọgba aghara, ọdịdọ na-enweghị nchịkwa) mgbe ị na-ewere rhabdomyolysis, atorvastatin kwesịrị ịkwụsị ma ọ bụ kwụsị ọgwụgwọ.

N'oge ọgwụgwọ na Tulip, ọ dị mkpa ịkpachara anya mgbe ị na-anya ụgbọ ala ma na-etinye ụdị ọrụ ndị ọzọ dị ize ndụ, nke chọrọ itinye nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

• cyclosporine, erythromycin, clarithromycin, immunosuppressive, antifungal ọgwụ (ọgwụ azole): mụbaa ihe banyere myopathy mgbe ejiri otu oge na HMG-CoA reductase inhibitors n'ihi mmụba nke ike na mkpokọta serum nke atorvastatin,
• indinavir, ritonavir (nje protease inhibitors), fibrates na nicotinic acid (na usoro nke iji belata ihe karịrị 1 g kwa ụbọchị): mụbaa ihe egwu nke myopathy,
• ndị na-egbochi CYP3A4 isoenzyme (gụnyere ndị na-egbochi nchebe): mmụba nke mkpokọta plasma nke atorvastatin ga-ekwe omume,
• OATP1B1 na-egbochi ndị na-egbochi protein (dịka cyclosporine): nwere ike iwelie bioavailability nke atorvastatin,
• erythromycin na clarithromycin: nwekwuo mkpokọta atorvastatin na plasma ọbara (site na 40% na 56%, otu isi),
• diltiazem: na onwa 240 mg na 40 mg nke atorvastatin na-eme ka ịta ọkwa nke ikpeazụ na plasma ọbara,
• cimetidine: enweghị mmekọrịta dị n'etiti ọgwụ na atorvastatin achọpụtara,
• itraconazole: na dose nke 200 mg na 20-40 mg nke atorvastatin, uru AUC nke atorvastatin ugboro atọ,
• ihe ọ juiceụụ mkpụrụ osisi grape: n'ime olu nke ihe karịrị 1.2 lita kwa ụbọchị maka ụbọchị 5 nwere ike ime ka mmụba na mkpokọta plasma nke atorvastatin,
• ndị na-enyocha CYP3A4 isoenzyme (dịka ọmụmaatụ, efavirenz ma ọ bụ rifampicin): nwere ike ibute mbelata nke atorvastatin na plasma ọbara, ebe ọ bụ na rifampicin bụ onye na-ewepụta isoenzyme CYP3A4 na n'otu oge ahụ inhibitor nke hepatocyte transport protein OATP, ọ bụ nke a,
• ọgwụ antacids: nchịkwa ọnụ nke njikọ nke nwere aluminom na magnesium hydroxides na atorvastatin belata ịta plasma nke ikpeazụ.

35%, mana ogo mbelata na mkpokọta nke LDL-C anaghị agbanwe agbanwe,

Ihe atụ nke Tulip bụ: Anvistat, Atomax, Ator, Atorvastatin, Atoris, Atorvoks, Vazator, Lipoford, Liptonorm, Liprimar, Torvazin, Novostat, Torvalip, Torvakard, Torvas na ndị ọzọ.

Mpempe usoro onunu ogwu

Mbadamba ihe mkpuchi.

1 otu mbadamba ihe mkpuchi fim nwere: ike ọrụ: atorvastatin calcium 41.43 mg (na usoro nke atorvastatin 40,00 mg), ndị na-ebu ụzọ: microcrystalline cellulose 284.97 mg, lactose monohydrate 69.60 mg, croscarmellose sodium 38.40 mg, hyprolose 4.00 mg, polysorbate 80 5.20 mg, magnesium oxide 52,00 mg, silloon silikon dioxide 2.40 mg, magnesium stearate 2.00 mg, ihe mejupụtara shei: hypromellose 5.952 mg, hyprolose 1.488 mg, titanium dioxide 2.736 mg, macrogol 6000 1,200 mg, talc 0,600 mg, iron oxide odo E 172 0,024 mg.

Nkọwa

A na-acha ọcha na -acha nchara-acha nchara nchara, mbadamba biconvex gbara gburugburu, nke a na-etinye ihe nkiri, nke a kpụrụ na “HLA 40” n'otu akụkụ.
Nlele anya: mbadamba ọcha.

Ngwongwo ogwu

Mlọ ọgwụ
Atorvastatin bụ ihe na - egbochi asọmpi HMG-CoA reductase enzyme nke na - agbanwe 3-hydroxy-3-methylglutaryl coenzyme A na mevalonic acid, nke bụ ihe na - ebido sterols, gụnyere kọlestrọl.
A na-etinye Triglycerides (TG) na cholesterol na nchịkọta nke lipoproteins dị ala (VLDL) dị ala n'oge njikọta imeju, banye na plasma ọbara ma na-ebuga ya na akwara anụ ahụ. A na-emepụta lipoproteins dị obere (LDL) site na VLDL n'oge mmekorita ndị na-anabata LDL.
Nnyocha e mere egosiwo na ịba ụba nke cholesterol dị na plasma, LDL na apolipoprotein B (Apo-B) na-atụnye ụtụ na mmepe nke atherosclerosis ma sokwa n'ihe ndị dị ize ndụ maka ọrịa obi, ebe ịbawanye ụba nke lipoproteins dị elu (HDL) na-ebelata ihe ize ndụ ahụ. mmepe nke ọrịa obi.
Atorvastatin na -ebelata mkpokọta cholesterol na lipoproteins na plasma ọbara n'ihi mgbochi nke Hhib-CoA reductase inhibitor, njikọ nke cholesterol na imeju na mmụba nke ndị na-anabata LDL nke “imeju” nke mkpụrụ ndụ, nke na-eduga n'ịba ụba na catabolism nke LDL.
Atorvastatin na-ebelata njikọta na itinye uche nke LDL cholesterol, cholesterol mkpokọta, Apo-B na ndị ọrịa nwere hyzycholesterolemia, hypercholesterolemia na hyperlipidemia jikọtara ọnụ.
Ọ na-ebute mbelata nke ịta cholesterol-VLDL na TG yana mmụba nke ịkpa oke cholesterol-HDL na apolipoprotein A (Apo-A).
N'ime ndị ọrịa nwere dysbetalipoproteinemia, mkpo nke lipoproteins nke ịdị elu nke cholesterol-LBP na-ebelata.
Atorvastatin na doses nke 40 mg na-ebelata mkpokọta cholesterol na 37%, LDL - site na 50%, Apo-B - site na 42% na TG - site na 29%, na-eme ka mmụba nke HDL cholesterol na Apo-A.
Dose na-agbadata mkpokọta LDL na ndị ọrịa nwere hyzycholesterolemia homozygous familialia, na-eguzogide ọgwụgwọ na ọgwụ ndị ọzọ na-egbusi ike.
O nweghi uto carcinogenic na mutagenic.
Mmetụta ọgwụgwọ ahụ na-ebido izu abụọ mgbe ebidochara usoro ọgwụgwọ, rute karịa mgbe izu anọ gachara ma dịgide na oge ọgwụgwọ niile.
Mlọ ọgwụ
Ndopu na nkesa. Idopu ihe n’ulo di elu. Nleta kachasị na plasma (Cmax) mgbe nchịkwa ọnụ gachara mgbe emesịrị 1 - 2 awa. Сmax n'ime ụmụ nwanyị dị 20% dị elu, mpaghara dị n'okpuru usoro nlebara anya oge (AUS) dị 10% ala karịa ụmụ nwoke, nke na-enweghị uru ọria. Сmax na ndị ọrịa nwere ọrịa imeju na-egbu egbu (klas B na ọnụ ọgụgụ ụmụaka-Pugh) bụ ugboro iri na isii, yana AUS - ugboro iri na otu dị elu karịa ka ọ dị.
Iri ura na -eme ka osooso nke ogwu a nwuo ngwa ngwa (site na 25% na 9%, dika otodi), iweda LDL cholesterol yiri nke ahu na atorvastatin n’enweghi nri oriri n’otu oge.
Mgbe nchịkwa ọnụ nke atorvastatin na mgbede, mkpokọta plasma dị ala (Cmax na AUC site na ihe dịka 30%) karịa mgbe nchịkwa n'ụtụtụ, Otú ọ dị, mbelata nke ịta LDL kọlesterol adịghị adabere n'oge ụbọchị eji ọgwụ a.
Ekpughela mmekọrịta dị n’agbata ogo igba mmata na ị ofụ ọgwụ.
Bioavailability bụ 12%, usoro sistemụ bioav adị nke ọrụ mgbochi megide Htr-CoA reductase bụ ihe dịka 30%. Site na usoro metabolism nke dị na eriri afọ (GIT) yana n'oge “ụzọ izizi” site na imeju.
Nkezi ogo nke nkesa bụ 381 l, ihe jikọrọ ya na protein protein plasma bụ 98%.
Ọbara atorvastatin n’arụ ọbara ọbara / plasma ọbara dị ihe dịka 0.25, ya bụ, atorvastatin anaghị abanye nke ọma n’ime sel ọbara.
Metabolism na ntụpọ. Atorvastatin bụ metabolized n'ime imeju site na omume nke isoenzymes CYP3A4, CYP3A5 na CYP3A7 na nguzobe nke ọgwụ na-arụ ọrụ ike (ortho- na para-hydroxylatederi, ngwaahịa beta-oxidation). Na vitro ortho- na parahydroxylated metabolites nwere mmetụta inhibitory na HMG-CoA reductase, dị ka nke atorvastatin. Mmetụta inhibitory ọgwụ a na-emegide HMG-CoA reductase bụ ihe dịka 70% kpebisiri ike site na ọrụ nke ịmegharị metabolites, nke na-adịgide ruo ihe dị ka awa 20 ruo 30, n'ihi ọnụnọ ha.
Nsonaazụ nyocha in vitro na-atụ aro na imeju CYP3A4 isoenzyme na-arụ ọrụ dị mkpa na metabolism nke atorvastatin. A kwadoro nke a site na mmụba nke mkpokọta atorvastatin na plasma ọbara mgbe ị na-ewere erythromycin, nke bụkwa ihe na-egbochi ịdịpụrụiche a.
Nchoputa in vitro gosikwara na atorvastatin bụ ihe na-adịghị ike nke CYP3A4 isoenzyme.
A na - apịpụ ya tumadi site na eriri afọ mgbe ọrịa hepatic na / ma ọ bụ extrahepatic metabolism (ọgwụ ahụ anaghị eme ka ọ pụta ihe na - emegharị ahụ). Ọkara ndụ (T1 / 2) bụ elekere 14. Ihe na-erughị 2% nke ọgwụ a na-ekpebi n’ime mmamịrị.
Achọghị ya ka ọ dịrị n'oge ịba ọcha n'anya n'ihi njikọkọ nke ukwuu na protin plasma.
Cmax na AUC nke ọgwụ dị na ndị ọrịa agadi (afọ 70 na okenye) bụ 40 na 30%, dị iche iche, dị elu karịa na ndị ọrịa na-eto eto, mana nke a enweghị uru ọgwụgwọ.
Ọrụ akụrụma anaghị arụ ọrụ gbasara ọgwụ ọgwụ a na plasma ọbara.

Jiri n’oge ime na n’oge a na-enye nwa ara

A na - egbochi ọgwụ ọgwụ Tulip ® n'oge afọ ime.
Ebe o bu na cholesterol na ihe ndi choputara n’ime cholesterol di nkpa maka mmepe nwa ebu n’onu, ihe ọghọm nke igbochi HMG-CoA mbelata ga-erite uru nke iji ọgwụ n’oge afọ ime.
Ọ bụrụ na achọpụtara afọ ime n’oge ọgwụgwọ Tulip ®, o kwesịrị ịkwụsị nchịkwa ya ozugbo enwere ike, dọọ onye ọrịa aka na ntị gbasara ihe nwere ike ibute nwa ebu n’afọ.
Enwere ike iji ọgwụ Tulip ® mee ọgwụ na ụmụ nwanyị toro ogologo ma ọ bụrụ na ihe ịtụrụ ime dị obere, ma meekwa ka onye ọrịa mara banyere ihe nwere ike ibute nwa ebu n’afọ n’oge ọgwụgwọ.
Mụ nwanyị nke afọ omumu kwesịrị iji ụzọ ịtụkwasị obi nke igbochi afọ n'oge ọgwụgwọ Tulip ®.
Atorvastatin dị na mmiri ara ara, ya mere, a na - egbochi ya maka oge a na - enye nwa ara, ọ bụrụ na ọ dị mkpa iji ọgwụ Tulip ® n'oge a na-enye nwa ara, a ga-akwụsị inye ya ara.

Usoro onunu ogwu na nhazi

Tupu iji ọgwụ ahụ Tulip drug mee ihe, onye ọrịa ahụ kwesịrị ikwu ezigbo usoro hypocholesterolemic, nke ọ ga-agbaso na-agbaso oge ọgwụgwọ niile.
Ọ na-atụ aro iji ọgwụ Tulip ® n'ime ime n'agbanyeghị oge nri.
Ọgwụ nke Tulip ® dị site na 10 mg ruo 80 mg kwa ụbọchị, ma ahọrọ ịhọrọ iburu n'uche ntinye uche nke LDL cholesterol, ebumnuche nke ọgwụgwọ na nzaghachi ọgwụgwọ onye na ọgwụgwọ ahụ.
Maka ọtụtụ ndị ọrịa, ọgwụ mbụ bụ 10 mg otu ugboro n'ụbọchị (ọ ga-ekwe omume iji ọgwụ ọjọọ atorvastatin n'ụdị usoro ọgwụ: mbadamba 10 na 20 mg).
Na nmalite ọgwụgwọ na / ma ọ bụ n'oge mmụba nke ọgwụ Tulip ®, ọ dị mkpa iji nyochaa oke nke lipids na plasma ọbara kwa izu abụọ na anọ ma mezie ọnụọgụ nke ọgwụ ahụ dabere.
Oke kachasị kwa ụbọchị bụ 80 mg / ụbọchị.
Ihe mbu (heterozygous hereditary na polygenic) hypercholesterolemia (ụdị IIa) na hyperlipidemia agwakọta (ụdị IIb)
Ikike mbu nke 10 mg nke ọgwụ Tulip ® 1 oge kwa ụbọchị (ọ ga-ekwe omume iji ọgwụ ọjọọ atorvastatin n'ụdị usoro ọgwụ: mbadamba 10 na 20 mg). Ọ bụrụ na ọ dị mkpa, mmụba nwayọ nwayọ na dose ruo 80 mg (mbadamba 40 nke 40 mg) ga - ekwe omume, dabere na mmeghachi omume nke onye ọrịa na izu dị ka izu abụọ na anọ, ebe ọ bụ na achọpụtara ọgwụgwọ ọgwụgwọ ka izu abụọ gachara, na nsonaazụ ọgwụgwọ kachasị mgbe izu anọ gachara. Site n'ọgwụgwọ ruo ogologo oge, mmetụta a na-adịgide. Homozygous hereditary hypercholesterolemia
A na-eji ọgwụ Tulip ® mee ihe n'ọtụtụ oge iji 80 mg (mbadamba abụọ nke 40 mg) otu ugboro n'ụbọchị.
Imezi ọgwụ Tulip ® nke ndị ọrịa na-arụ ọrụ na-arụ ọrụ ezumike na ndị agadi achọghị ya.
Mgbochi Ọrịa Obi
A na-eji Tulip ® eme ihe na ọgwụ iri 10 mg otu ugboro n'ụbọchị. Ọ bụrụ na erughi plasma LDL kachasị mma, ọ ga-ekwe omume ịbawanye ọgwụ nke ọgwụ ahụ ka 80 mg kwa ụbọchị, dabere na mmeghachi omume onye ọrịa na oge dị ka izu abụọ ruo izu anọ.
N'ime ndị ọrịa nwere ọrụ imeju na -akwụsị, njiri nke atorvastatin site na ahụ na-adalata, yabụ na-atụ aro iji ya kpachara anya na nlezianya na-ahụ maka ọrụ nke “imeju” transaminases: aspartate aminotransferase (AST) na alanine aminotransferase (ALT). Ọ bụrụ na mmụba a hụrụ na ọrụ AST ma ọ bụ nke ALT karịa ugboro 3 ma e jiri ya tụnyere njedebe dị elu nke nkịtị (VGN) ga-adịgide, a na-atụ aro ka ibelata dose ma ọ bụ kagbuo ọgwụ Tulip ®.

Mmetụta akụkụ

Dabere na Healthtù Ahụ Ike (wa (WHO), a na-ekewa mmetụta ndị na-achọghị dịka oge ha nke mmepe dị ka ndị a: ọtụtụ mgbe (> 1/100, 1/1000, 1/10000,
mgbe: mmeghachi omume nfụkasị ahụ
adịkarịghị: anafilaisis.
Site na sistemụ akwara na akụkụ ahụ
mgbe: isi ọwụwa
ugboro ugboro: anya ntughari, nsogbu ịrahụ ụra, gụnyere ehighị ụra nke ọma na nro “ụra abalị”, ọrịa asthenic, adịghị ike, paresthesia, hypesthesia, mmetụta uche na-adịghị mma, mfu ma ọ bụ ibelata ncheta,
adịkarịghị: nsogbu neuropathy akụkụ.
Site na ngwe nri
mgbe: afọ ntachi, afọ, dyspepsia, ọgbụgbọ, afọ ọsịsa,
ugboro ugboro: anorexia, vomiting, pancreatitis, ịba ọcha n'anya, ime ime, belching,
adịkarịghị: jalestice cholestatic (gụnyere igbochi),
adịkarịghị: imeju imeju.
Site na usoro akwara na uru ahụ
mgbe: myalgia, ogbu na nkwonkwo, ihe “nkwonkwo” nke nkwonkwo, mgbu mgbu, azụ mgbu, akwara umeji,
ugboro ugboro: olu mgbu n’olu, adighi ike,
adịkarịghị: myopathy, myositis, rhabdomyolysis, tendinopathy (mgbe ụfọdụ, ọ na-agbasi mbọ ike),
amaghi ugboro: necrotizing myopathy na-egbochi ogbugba.
Site na anụ ahụ anụ ahụ
ugboro ugboro: tinnitus, ọhụhụ ụzọ,
adịkarịghị: mmebi anya
adịkarịghị: okfu nụ.
N'akụkụ nke anụ ahụ na abụba subcutaneous
ugboro ugboro: urticaria, ihe nchachi isi na itching, alopecia,
adịkarịghị: ọrịa angioedema, ihe ọkụ ọkụ, polymorphic exudative erythema (gụnyere ọrịa Stevens-Johnson syndrome), necrolysis na-egbu egbu (Lyell syndrome).
Site n'akụkụ nke metabolism
mgbe: hyperglycemia
ugboro ugboro: hypoglycemia, ibu ibu.
Site na akụkụ ahụ dị na hemopoietic
ugboro ugboro: thrombocytopenia.
Site na sistem iku ume
mgbe: nasopharyngitis, akpịrị mgbu, imi n'ọnụ.
Ihe ngosi ulo oru
mgbe: mmụba nke serum creatinine phosphokinase (CPK), ụba ọrụ nke “transpore“ imeju ”.
ugboro ugboro: leukocyturia,
amaghi ugboro: ịba ụba nke glycosylated haemoglobin.
Ndị ọzọ:
ugboro ugboro: ike ọgwụgwụ, oke nwere nsogbu, ọdịda akwara nke abụọ, ahụ ọkụ, mgbu obi, ọgụ mkpụrụedemede,
adịkarịghị: gynecomastia, ọrịa shuga mellitus. Enwere akụkọ dị iche na mmepe nke atciiki fasciitis (njikọta na iji atorvastatin edozighi ya n'ụzọ ziri ezi).
amaghi ugboro: ịda mba, ọrịa ngụgụ (ọkachasị na usoro ọgwụgwọ ogologo oge), nsị mmekọahụ.

Dodoụbiga ya ókè

Enweghị ọgwụ mgbochi akọwapụtara maka ọgwụgwọ nke ịdoụbiga mmanya ókè.
Ọ bụrụ na ị doụbiga ya ókè, a ga-ebu ọgwụgwọ Symptomatic.
Ọkpụkpụ anụ ahụ adịghị arụ ọrụ (n'ihi na ọgwụ ahụ na-ejikọ protein protein dị ala).

Mmekọrịta na ọgwụ ndị ọzọ

Ihe ọghọm nke myopathy n’oge ọgwụgwọ na HMG-CoA reductase inhibitors na-abawanye site na iji otu oge cyclosporine, erythromycin, clarithromycin, immunosuppressive, antifungal ọgwụ (ọgwụ azole) n'ihi mmụba enwere ike na ntinye nke atorvastatin n'ime ọbara.
Iji nke imekotaotuugbo iji Ndị na - egbochi nje HIV - indinavir, ritonavir ihe egwu nke ime myopathy na-abawanye.
Enwere ike imekọrịta ụdị mmekọrịta ahụ n'otu oge iji atorvastatin yana fibrates na acid nicotinic na usoro iji egbugbere ọnụ belata (karịa 1 g / ụbọchị).
Ndị na-egbochi CYP3A4 Isoenzyme
Ebe ọ bụ na atorvastatin bụ metabolized site na iji isoenzyme CYP3A4, iji ọgwụ a jikọtara ọnụ Tulip ® na ndị na - egbochi aechezyme nwere ike ibute mmụba nke atorvastatin na plasma ọbara. A na-ekpebi ogo nke mmekọrịta na mmetụta nke ịba ụba nke atorvastatin site na mgbanwe dị iche iche nke nsonaazụ ahụ na CYP3A4 isoenzyme.
OATP1B1 na-egbochi ndị na-egbochi protein
Atorvastatin na metabolites ya bụ mkpụrụ nke protein ebugharị OATP1B1.
Ndị na-egbochi OATP1B1 (dịka ọmụmaatụ, cyclosporine) nwere ike iwelie bioavailability nke atorvastatin. Yabụ, iji atorvastatin na dose 10 mg na cyclosporine na dose 5.2 mg / kg / ụbọchị na-eduga na mmụba nke mkpokọta atorvastatin na plasma ọbara site na ugboro 7.7.
Erythromycin / clarithromycin
Site na oge nke atorvastatin 10 mg na erythromycin (500 mg 4 ugboro n'ụbọchị) ma ọ bụ clarithromycin (500 mg 2 ugboro n'ụbọchị), nke na-egbochi isoenzyme nke cytochrome CYP3A4, enwere mmụba na mkpokọta atorvastatin na plasma ọbara (site na 40% mgbe ejiri ya erythromycin na 56% - mgbe ejiri clarithromycin mee ihe).
Na-egbochi ndị na-egbochi gị
Ojiji atorvastatin na-egbochi ya na ndị na-egbochi nchebe nke a maara dị ka ndị na-egbochi cytochrome CYP3A4 isoenzyme so na mmụba nke atorvastatin na plasma ọbara (ya na erythromycin na-eme n'otu oge, Cmax nke atorvastatin na-abawanye 40%).
Diltiazem
Nchikota atorvastatin na uzo 40 mg na diltiazem na onwa 240 mg na-eduga na mmụba nke mkpokọta atorvastatin na plasma ọbara.
Cimetidine
Enweghị mmekọrịta dị omimi nke atorvastatin na cimetidine achọpụtara.
Itraconazole
N'otu oge, atorvastatin na onunu si na 20 mg ruo 40 mg na itraconazole na ntụtụ nke 200 mg na-eduga na mmụba okpukpu atọ na AUC nke atorvastatin.
Ihe ọ juiceụ Graụ mkpụrụ osisi grape
Ebe ọ bụ ihe ọ juiceụpeụ mkpụrụ osisi grape nwere otu ma ọ bụ karịa ihe na-egbochi CenP3A4 isoenzyme, ị itsụbiga ya ókè (karịa 1.2 lita kwa ụbọchị maka ụbọchị 5) nwere ike ibute mmụba nke plasma nke atorvastatin.
CYP3A4 Isoenzyme Inductors
Ihe atorvastatin jikọtara ya na ndị inenzyme CYP3A4 dị ka ọmụmaatụ (efavirenz ma ọ bụ rifampicin) nwere ike ibute mkpokọta mkpokọ atorvastatin na plasma ọbara. N'ihi ụzọ mkparịta ụka na rifampicin (inducer nke CYP3A4 isoenzyme na hepatocyte trans protein inhibitor OATP1B1), anaghị atụ aro iji otu oge atorvastatin na rifampicin, ebe ọ bụ na igbu oge na atorvastatin mgbe rifampicin na-eduga na mbelata nke ọbara na atorvastatin.
Antacids
N'iji oge nke atorvastatin na nkwusioru nke nwere magnesium na aluminom hydroxides n’ime, nnabata nke atorvastatin na plasma na-ebelata ihe dika 35%, agbanyeghị, ogo mbelata nke ịta LDL cholesterol agbanweghi.
Phenazone
Atorvastatin anaghị emetụta ọgwụ ọgwụ nke phenazone, yabụ, ị na-ejikọ mmekọrịta ọgwụ ndị ọzọ metabolized site na otu isoenzymes ahụ.
Colestipol
Mmetụta dị ala nke njikọta na colestipol dị elu karịa nke a maka ọgwụ ọ bụla iche, n'agbanyeghị ogo 25% na mkpokọta nke atorvastatin mgbe ejiri colestipol jiri ya mee ihe.
Fusidic acid
Emebeghị nnyocha banyere mmekọrịta nke atorvastatin na fusidic acid. Dika odi na onodu ndi ozo, ihe omumu banyere ahia banyere ojiji nke atorvastatin na fusidic acid egosiputala nsonaazụ na akwara, gụnyere rhabdomyolysis. Amaghi uzo esi emekorita ihe. Ndị ọrịa dị otú a chọrọ nlezianya nyocha na, ikekwe, ịkwụsị nke atorvastatin.
Nchikota
Ọ bụ ezie na emebeghị nnyocha banyere mmekọrịta nke atorvastatin na colchicine, a kọwo banyere myopathy mgbe ejikọtara ya na colchicine, a ghakwara ịkpachara anya mgbe ị na-edepụta atorvastatin na colchicine.
Digoxin
Site na iji digoxin na atorvastatin ugboro ugboro na 10 mg, nha anya itinye digoxin na plasma ọbara adịghị agbanwe agbanwe. Agbanyeghị, mgbe ị na-eji digoxin na njikọ na atorvastatin na dose 80 mg / ụbọchị. ịta nke digoxin na plasma ọbara na-abawanye ihe dị ka 20%. Ndị ọrịa na-a digụ digoxin na atorvastatin chọrọ maka nlebara anya nke mkpokọta digoxin na plasma ọbara.
Azithromycin
Site n’otu oge iji atorvastatin na onwa 10 mg 1 oge / ụbọchị na azithromycin na dose nke 500 mg 1 oge / ụbọchị, itinye uche nke atorvastatin na plasma ọbara adịghị agbanwe.
Ogwu ogwula ogwu
Iji otu oge atorvastatin na mgbochi mkpịsị nke nwere norethisterone na ethinyl estradiol, enwere mmụba dị ukwuu na AUC nke norethisterone na ethinyl estradiol dịka 30% na 20%, n'otu n'otu, nke a ga-echebara mgbe ị na-ahọrọ ọgwụ mgbochi ogwu.
Terfenadine
Atorvastatin nwere ojiji a na-ejikọta ya na terfenadine enweghị mmetụta dị ukwuu na ụlọ ọgwụ na ọgwụ pharmacokinetics nke terfenadine.
Warfarin
N'ime ndị ọrịa na-a warụ ọgwụ warfarin ogologo oge, atorvastatin na ọgwụ nke 80 mg kwa ụbọchị dịkarịrị obere oge prothrombin na ụbọchị mbụ nke ijikọ aka. Mmetụta a na-apụ n'anya mgbe ụbọchị iri nke ọgwụ ndị a na-eme n'otu oge. Agbanyeghị na ekwuputala banyere ọrịa mgbanwe dị egwu na anticoagulant mmetụta dịkarịsịrị ala, a ga-ekpebi oge prothrombin na ndị ọrịa na - ewere ọgwụ coumarin anticoagulants tupu oge na - ezuru mmalite nke ọgwụgwọ na atorvastatin iji hụ na enweghị mgbanwe mgbanwe dị ukwuu na oge prothrombin. Ozugbo edere oge prothrombin kwụsiri ike, enwere ike ịlele ya na oge ndị ọrịa na-a coụ ọgwụ coumarin anticoagulants. Ọ bụrụ n’ịgbanwe dose ahụ ma ọ bụ kwụsị ọgwụgwọ, ekwesịrị imeghachi ihe ndị a. Enweghị njikọ n'etiti ojiji nke atorvastatin na ọbara ọgbụgba ma ọ bụ mgbanwe n'oge prothrombin na ndị ọrịa na-adịghị anticoagulants.
Amlodipine
Site n’otu oge eji atorvastatin na dose nke 80 mg na amlodipine na dose nke 10 mg, ọgwụ ọgwụ nke atorvastatin na nguzozi agbanweghi.
Ọgwụ ndị ọzọ na-eme ka egbusi ike gwụ
Site na iji atorvastatin na-eme n'otu oge yana ọgwụ hypoliplera (dịka ọmụmaatụ, ezetimibe, gemfibrozil, ihe na-egosi fibroic acid) na belata doses, ihe ize ndụ nke ịmalite rhabdomyolysis na-abawanye.
Usoro ọgwụgwọ concomitant ndị ọzọ
Site na iji atorvastatin jikọtara ọnụ na ọgwụ antihypertensive na estrogens (dị ka usoro ọgwụgwọ nnọchi), enweghị nchọpụta mmekọrịta dị ịrịba ama na ụlọ ọgwụ.

Ngwa ọgwụ nke Tulip

Dabere na ntuziaka maka Tulip, ihe na-arụ ọrụ nke ọgwụ ahụ bụ atorvastatin. Ihe ndị mejupụtara mbadamba nkume ndị ahụ bụ magnesium stearate, silloon silikon dioxide, magnesium oxide, ssum croscarmellose, polysorbate 80, hydroxypropyl cellulose, lactose monohydrate, microcrystalline cellulose.

Tulip bụ ihe nhọta na-egbochi asọmpi HMG-CoA na enzyme nke na - etinye aka na mgbanwe nke 3-hydroxy-3-methylglutaryl coenzyme A n'ime mevalonate, nke bụ ihe ga - ebido steroid.

Ebumnuche ọgwụ a na-achọ inweta mbelata dị ukwuu:

• njikọ na ọdịnaya nke mkpokọta cholesterol,
• ego na nchịkọta nke LDL ụmụ irighiri ọbara,
• larịị nke TG na apolipoprotein B,
• ọghọm nke ibute ọrịa na ọrịa obi.

Tulip na-enye aka na nhazi nke ọkwa nke HDL ụmụ irighiri ihe na apolipoprotein A.

Ọgwụ ahụ na-agbadata ọkwa LDL na ndị nwere ọrịa hyzycholesterolemia ketara eketa nke na-eguzogide ọgwụ ndị ọzọ na-eme ka mkpụrụ ndụ daa.

Mgbe a na-eduzi ya, Tulip na-agbari nke ọma ma na-agbakarị ọsọ ọsọ. Oke itinye uche na plasma ruru mgbe elekere abụọ gachara. Ọ nwere bioavailability dị ala ma nwee njikọ chiri anya na protein protein. Ọ bụ metabolized na imeju na nguzobe nke ọtụtụ ọgwụ na-arụ ọrụ metabolites. Oge iwepu ọgwụ kpamkpam n’ahụ bụ elekere 28. Ọ bụ mịrị amịrị na eriri afọ.

Usoro onunu ogwu na nhazi nke tulip

Tupu ịmalite ọgwụgwọ, a ga-ebugharị onye ọrịa ka ọ bụrụ nri cholesterol dị ala. A na - ewere ọgwụ ọnụ Tulip otu oge 1 ụbọchị kwa ụbọchị, n'agbanyeghị nri oriri.

A na-ahọpụta usoro ị drugụ ọgwụ ahụ site na dọkịta na-aga na ya maka ndị ọrịa ọ bụla, dabere na ebumnuche ọgwụgwọ yana ọkwa LDL-C. Dịka iwu, ọgwụ Tulip dịgasị site na 10 ruo 80 mg. Emeghari usoro ọgwụgwọ a na-eme 1 oge n'ime izu anọ.

Mlọ ọgwụ

Nnweta nke ọgwụ dị elu. Enwere ike itinye uche gị na plasma ọbara kachasị elu 1-2 awa mgbe ị theụsịrị ọgwụ. Ọ bụrụ na ị theụọ ọgwụ ahụ na mgbede, ntinye ya n'ọbara ga-adị ala ma e jiri ya tụnyere nke ahụ e dere na plasma ọbara mgbe nchịkwa n'ụtụtụ.

Bioavod dị na 12-14%. Mgbatị ahụ bụ site na eriri afọ, ihe na-erughị 2% ọgwụ a ka edobere na mmamịrị.

Jiri nlezianya

N'ọnọdụ ụfọdụ, a ga-eji nlezianya mee nhọpụta ahụ. Nke a bụ ọnụnọ nke ọnọdụ ndị a:

• ezigbo elektrọnikal,
• mọzụlụ sistem
• ọrịa shuga mellitus
• endocrine na nsogbu nke metabolic,
• Akwụkwụ na-adọ
• hypotension akwara,
• sepsis
• akụkọ banyere ọbara ọgbụgba.

Eji akpukpo ahihia eji ahihia aru.
Ejiri ọgwụ ịgwọ ọrịa shuga kwadebe ya.
Edinyere ọgwụ ah ị jiri nlezianya nye ndị ọrịa nwere ọria ụbara.

Etu esi ewere tulip?

Tupu ịmalite usoro ọgwụgwọ, ịkwesịrị ịnye onye ọrịa ndụmọdụ banyere otu esi agbaso usoro nri iji belata cholesterol ọbara. Onye ọrịa ọ bụla kwesịrị ịmụ ntuziaka maka ojiji.

Kedu ụdị ọgwụ a ga-ahọrọ dabere na nchịkọta nke cholesterol n'ime ọbara, afọ onye ọrịa yana etu e si eleghara usoro ọrịa ahụ anya.

Ikwesiri were mbadamba nkume ndị ahụ n’ime, iri nri adịghị emetụta arụmọrụ nke oriri ha.

Usoro onunu ogwu nwere ike iru site na 10 ruo 80 mg kwa ubochi. Ọgwụ izizi bụ 10 mg. Ka izu ọgwụ 2-4 gachara, dibịa ahụ na-enyocha ihe ndị dị na lipids n'ọbara onye ọrịa. A na-eme nke a iji kpebie nhazigha usoro onunu ogwu.

Ikwesiri were mbadamba nkume ndị ahụ n’ime, iri nri adịghị emetụta arụmọrụ nke oriri ha.

Iji gbochie ọrịa nke obi na akwara, a na-eji doses nke 10 mg kwa ụbọchị. Na ọgwụgwọ nke hyzycholesterolemia nke homozygous, a na-egosi ya iji mbadamba 2 nke 40 mg kwa ụbọchị, i.e. nke a bụ usoro ọgwụ nke 80 mg.

Ọkpụkpụ afọ

Mgbaàmà ndị a na-ahụkarị bụ ọgbụgbọ, ọgbụgbọ na afọ ọsịsa, flatulence na afọ ntachi. Ihe nrịba ama a na-adịghị ahụkebe bụ vomiting, pancreatitis, belching na mgbu n'ime afọ.

Udiri ugboro ugboro mgbe iwere mbadamba nkume ndị ahụ dị ka ọgbụgbọ, vomiting.
Mgbe ị na-eji ọgwụ ahụ, ị ​​nwere ike izute ụdị ngosipụta ndị dị ka mgbu n'ime afọ.
Ngosipụta kachasị mgbe ejiri mbadamba nkume ndị ahụ kwesịrị ịtụle isi ọwụwa.

Site na sistem iku ume

Ikekwe mmepe nke nasopharyngitis, ọdịdị ọbara ọgbụgba site na imi na ọnya na akpịrị.

Ọzọkwa, onye ọrịa ahụ nwere ike ịnwe ọbara ọgbụgba na anya anya.
Site na usoro iku ume, ọbara ọgbụgba site na imi ga-ekwe omume.
Mgbe ọ usingụsịrị ọgwụ ahụ, onye ọrịa ahụ nwere ike ịta ahụhụ urticaria na ihe ọnya.

Mmanya ndakọrịta

A drinkụla mmanya mgbe ị na-a theụ ọgwụ.

Ide akwụkwọ ọgwụ n'oge gest agaghị ekwe omume.
A drinkụla mmanya mgbe ị na-a theụ ọgwụ.
N’oge ịgwọ ọrịa ọgwụ, i kwesịrị ịkpachara anya mgbe ị na-akwọ ụgbọala.
Ebe ihe na-arụ ọrụ na-abanye n’ime mmiri ara, i kwesịghị inye nwa ọhụrụ n’oge ịgwọ ọrịa.

Jiri n'oge ime na lactation

Ide akwụkwọ ọgwụ n'oge gest agaghị ekwe omume. Ọ bụrụ na nwanyị dị ime n’oge usoro ọgwụgwọ, ọ dị mkpa ịgwa ndị dọkịta banyere nke a ngwa ngwa o kwere omume ma kwụsị ị withụ ọgwụ ahụ. Ebe ihe na-arụ ọrụ na-abanye n’ime mmiri ara, i kwesịghị inye nwa ọhụrụ n’oge ịgwọ ọrịa.

Jiri na agadi

Imeghari udiri ọgwụ a tụrụ aro adịghị mkpa.

Ebe ọ bụ na etoliteghị ịdị irè na nchekwa nke ọgwụ maka ụmụaka na-erubeghị afọ 18, akwadoghị ị takingụ ọgwụ n'oge a.

Enwere m ike ịzụta na ndenye ọgwụ?

Ọ gaghị ekwe omume ịzụta ọgwụ na-enweghị ndenye ọgwụ.

Nwere ike ịzụta ọgwụ ahụ n'ụlọ ọgwụ niile dị na mpaghara nke Russian Federation.
Nwere ike dochie ọgwụ dịka Atoris.Torvacard bụ ọgwụ yiri nke ahụ.
Na-echekwa ọgwụ n'ụlọ okpomọkụ.
Ọnụ ego nke ngwaahịa a na-amalite site na 300 rubles.

Ọnụ ego nke ngwaahịa a na-amalite site na 300 rubles.

Nyocha Tulip

Nyocha banyere ngwá ọrụ na-akacha mma.

A.Zh. Delikhina, onye na-ahụ maka izugbe, Ryazan: "Ngwá ọrụ ahụ na-enye gị ohere inweta nsonaazụ kachasị mma n'ọgụ megide ọgụ dị elu cholesterol n'ọbara nke ndị ọrịa."

E.E. Abanina, Endocrinologist, Perm: “Edere ọgwụ ahụ maka ọgwụgwọ ndị ọrịa. Ọzọkwa, dọkịta na-enyocha ọnụ ọgụgụ onye ọrịa ahụ site n'oge ruo n'oge. ”

Torvacard: analogues, nyocha, ntuziaka maka ojiji Atorvastatin.

Karina, onye dị afọ 45, Omsk: “Ngwá ọrụ ahụ nyeere aka wezuga nsogbu na usoro akwara obi. Ana m ekele ndị dọkịta maka idepụta ọgwụ a. Ego a na-akwụ ụgwọ nkịtị. ”

Ivan, onye gbara afọ 30, Adler: “Ọgwụ a dị mma maka mmụba nke cholesterol n'ọbara. Nsogbu a na-ebilitekarị n'ihi nri adịghị edozi nke nwere ọtụtụ nri eghe. O wee mee. Aghaghị m ịhụ dọkịta, gafere ule dị mkpa ma gaa ọgwụgwọ. ”

Mlọ ọgwụ

Akụkụ na-arụ ọrụ n'ime ọgwụ ahụ bụ atorvastatin, nke bụ ihe nnọchianya maka ụmụ irighiri ihe HMG-CoA reductase. Mbelata na-ahụ maka njikọ mevalonic acid, nke bụ akụkụ nke sterols na molecule cholesterol.

Molecules nke cholesterol na triglyceride bụ akụkụ nke ụmụ irighiri ihe nke lipoproteins nke ogo nnukwu ala, nke jikọtara n'oge mkpokọta ha na akwara akwara.

Mgbe a na-ejikọ ụmụ irighiri ihe na VLDLP na ndị na-anabata LDL, triglycerides na-ewepu lipoprotein dị ala dị ala na obere ogo nke lipoproteins dị ala.

Molecules na-abanye ọbara ma na-ebufere ya n'ọbara na-aga n'akụkụ akụkụ niile nke ahụ.

Aha Tulip ndị ọzọ

Site na mmụba na mkpokọta na plasma ọbara nke cholesterol zuru ezu, yana obere irighiri ihe dị n'ime mpe mpe akwa na ụmụ irighiri ihe nke B, enwere ihe ize ndụ nke imepụta usoro ọrịa nke atherosclerosis.

Ọzọkwa, mmụba nke irighiri ihe dị ala dị ala bụ́ lipoproteins na-amụba ohere o nwere ibute ọrịa na-emetụta akwara obi na sistem ọbara, na mmụba dị ukwuu nke lipoproteins na-ebelata ihe ize ndụ nke ọrịa ndị a.

Ihe mejupụtara atorvastatin dị ala na - agbadata mkpokọta cholesterol na ọbara, na - emekwa ka ọnụọgụ nke ndị na - anabata LDL na - abawanye catabolism nke cholesterol dị ala, belata ya.

Ihe mejupụtara atorvastatin na-egosi nsonaazụ ọgwụ kachasị mma na ọgwụgwọ nke:

• Homozygous hereditary hypercholesterolemia,
• Heterozygous mkpụrụ ndụ ihe nketa ezinụlọ hypercholesterolemia,
• Isi akwukwo nke hypercholesterolemia,
• Ọgwakọta nke ọrịa hyperlipidemia.

Tnweta Tulip na-eme ka mkpokọta protein dị elu nke moleculeins, yana ụmụ irighiri akwara Apọkrosrotein A1 n'ime ọbara.

Tulip ọgwụ nwere onunu ogwu nke 120.0 milligram na 20.0 milligrams na-ebelata itinye uche na ọbara:

• Nkpukpo cholesterol ndekota na — 29,0% — 33,0%,
• Mkpụrụ ndụ LDL na — 39,0% — 43,0%,
• Mkpụrụ ndụ APO B na — 32,0% — 35,0%,
• Triglycerides na — 14,0% — 26,0%.

Mmekọrịta na ọgwụ ndị ọzọ

• Ọgwụ Antacid na-ebelata mkpụkọ tulip n'ọbara n'ọbara site na 35.0%
• Mgbe ewere digoxin, enwere nsogbu nke ibute ọrịa nke akwara obi na nsogbu n’ọbara mgbasa ọbara.
• Ọgwụ nje nke erythromycin na clarithromycin otu, na-abawanye ụba nke plasma nke ọgwụ Tulip,
• A na-anabata nkwado maka ọgwụ mgbochi ọgwụ homonụ na tulip.

Mmechi

Enwere ike ịgwọ gị naanị ya na anụ ahụ dịka dọkịta nyere gị iwu ma echefula na iji belata ndekọ cholesterol ịchọrọ iji nri ma bie ụdị ndụ dị mma. Naanị na njikọta ọgwụgwọ nwere ike belata mkpokọta cholesterol na mgbochi nke atherosclerosis.

Mgbe ị na-eji Tulip eme ihe dị ka ihe mgbochi nke abụọ, a na-ebelata ihe ize ndụ nke nkụchi obi na ọnwụ site na ọrịa ụbụrụ na infarction.

Oksana, 39 afọ: Edere m Tulip mgbe kọlestrọl dị 7.3 mmol kwa otu lita, mana enwere ọtụtụ mmetụta n'akụkụ akwa ahụ. Anọwo m na-ewere statin a ọnwa anọ. My cholesterol laghachiri na nkịtị, naanị ahụike m agbakebeghị.

George, dị afọ 58: Achọpụtala m cholesterol dị afọ 14. Aụrụ m ọgwụ dị iche iche nke statins na fibrates.

Enwere m ọrịa shuga, ya mere cholesterol na-amaze elu oge niile. Dabere na atorvastatin, m na-ewere Tulip ruo afọ 2.

Ngụgụ egbugbere ọnụ bụ ihe dị mma na ahụike m dị oke mma. Nke a bụ ọgwụ mbụ nke anaghị eme ka mmeghachi omume dị njọ n’ahụ m.