Onye na-achịkwa agụụ nri Meridia: ihe mejupụtara na ntinye maka ọgwụ a

Iji felata, ọtụtụ ụmụ agbọghọ na ụmụ nwanyị chọrọ ime ka ọnụọgụ ha dị ka ezigbo, na-a medicationsụ ọgwụ pụrụ iche. Themfọdụ n’ime ha nwere ihe dị ka sibutramine. Dabere na ihe a, ọgwụ Meridia maka ịbelata oke.

Tupu ifelata n'ụzọ dị otu a, ịkwesịrị ịmụ banyere ntuziaka maka ojiji Meridia, nke enyere n'okpuru.

Meridia: ihe mejupụtara na ukpuru omume

Ihe na - arụ ọrụ nke ọgwụ Meridia bụ subatramine hydrochloride monohydrate. Dika ndi adjuvants, ogwu nwere ihe ndi ozo dika silikon dioxide, titanium dioxide, gelatin, cellulose, sodium sulfate, dyes, wdg. A na-ejikarị Capsules agwọ ndị mmadụ buru oke ibu.

Meridia ọgwụ dị n'ụdị capsules nke usoro dịgasị iche iche:

• 10 miligram (shei ahụ nwere agba odo na-acha anụnụ anụnụ, ntụ ntụ ọcha dị n'ime),
• 15 milligrams (ikpe ahụ nwere agba na-acha ọcha-acha anụnụ anụnụ, ihe dị n'ime ya bụ ntụ ntụ).

Ngwa nri slimming nke Meridia nwere ụdị ọgwụgwọ dị iche iche ma nwee mmetụta ndị a na ahụ:

• na-abawanye ọkwa nke serotonin na norepinephrine na ndị na-anabata usoro ụjọ ahụ,
• na-egbochi agụụ
• na-enye afọ ojuju,
• na-eme ka ọ̀tụ̀tụ̀ hemoglobin na glucose dị ala,
• na - eme ka ahụ mmadụ nwee okpomoku okpomoku.
• normalizes lipid (abụba) metabolism,
• na-akpali mmebi nke abụba aja aja.

Ihe ndị dị na ọgwụ ahụ na-abanye ngwa ngwa diges na-agbaze, na-agbajikwa na imeju ma na-enweta oke ha n'ọbara ruo awa atọ mgbe ịwachara ya. A na - ewepụ ihe ndị dị nro site n'ahụ ahụ n'oge mmịkọ na nsị.

Ihe ngosi maka ojiji

Ojiji nke Meridia nke ogwu a gosiputara ndi mmadu dika ọgwụgwọ mmezi nke oria dika:

• oke ibu, nke ihe mejupụtara aru mmadụ karịrị kilogram 30 n'otu kilogram,
• Ibu oke ibu, tinyere oria mamellitus ma obu metalu metabolism nke sel di n’ime ya, ebe otutu ihe di n’ime ya kariri kilogram 27 n’arọ.

Ntụziaka maka ojiji

Were okpu Meridia dịka ntuziaka ahụ si dị, nke a na-ejikọ ya na ọgwụ mgbe niile:

• na-a capụ capsules otu ugboro n'ụbọchị (a naghị ata ata ọgwụ, kama ọ bụ otu iko mmiri dị ọcha),
• ọ kachasị mma iji ọgwụ anorexigenic n'ụtụtụ tupu nri ma ọ bụ nri,
• usoro mbụ kwa ụbọchị nke Meridia kwesịrị ịbụ milligrams 10,
• ma ọ bụrụ na ọgwụ nwere ezigbo ntachi obi, mana anaghị ekwupụta nsonaazụ (n'ọnwa, ọ ga-eme ka ịdị arọ onye ọrịa belata na-erughị kilogram abụọ), a ga-abawanye ọgwụ a na-eme kwa ụbọchị ruo milligram 15.
• ọ bụrụ na n’ime ọnwa atọ mbụ ị ofụ ọgwụ ahụ, ịdị arọ ahụ belatara nanị 5% (ebe onye ọrịa ahụ ji ọgwụ a na-a capụ ọgwụ ọ millụ millụ 15 milligrams), a na-akwụsị iji Meridia,
• mwepu nke capsules ga-achokwa ọnọdụ mgbe mmadụ mgbe obere obere anaghị ebido iwepu ya, kama nke ahụ, nweta kilogram (site na kilogram atọ na elu),
• ị Merụ ọgwụ Meridia enweghị ike iru ọnwa 12 ọzọ,
• mgbe ị na-a anoụ ọgwụ ọgwụ anorexigenic, onye ọrịa ahụ kwesịrị ịrapara na nri ahụ, na-agbaso ụdị nri ndị dọkịta nyere ma na-eme ọgwụgwọ anụ ahụ, mmadụ aghaghị ịnọgide na-ebi ụdị ndụ ahụ mgbe a gwọchara ya (ma ọ bụghị, nsonaazụ ahụ nwere ike ịkwụsị ngwa ngwa),
• A ga-echekwa ụmụ agbọghọ na ụmụ nwanyị toro afọ na ị andụ ọgwụ Meridia site na afọ ime, na-eji ọgwụ mgbochi ndị a pụrụ ịdabere na ha,
• Agaghị atụle mbadamba nkume Meridia na ị alcoholụ mmanya, nchikota nke ethyl mmanya na ihe na-arụ ọrụ nke ọgwụ anorexigenic nwere ike ịkpasu mmepe nke mmeghachi omume ọjọọ nke na-etinye ahụ mmadụ n'ihe ize ndụ.
• N'oge ọgwụgwọ niile, onye ọrịa ahụ ga na-enyocha ọkwa nke mgbali ọbara na ọnụego obi ya, ma nyochaa ihe ndị dị na uric acid na lipids n'ime ọbara.
• iji capsules, mmadụ kwesịrị ịkpachara anya karịsịa mgbe ọ na-anya ụgbọ ma na-arụ ọrụ site na usoro nyocha nke teknụzụ, dị ka ọgwụ a nwere ike wedata anya gị,
• ekwesighi ị drugụ ọgwụ ahụ n'otu oge iji ọgwụ mgbochi antidepressant ọ bụla.

Ngwurugwu mgbochi na nsonaazụ ya

Recenata capsule anorexigenic bụ Meridia na ọrịa na ọrịa dịka:

• nsogbu uche (gụnyere anorexia na bulimia),
• ọgwụ ọjọọ riri ahụ
• ọrịa hypertensive
• prostate adenoma
• ọrịa ndị metụtara obi na ọbara,
• gbasara akwara
• lactose anagide ihe,
• hypersensitivity nke mmiri ọgwụ,
• jisie umeji imeju,
• oke abụba kpatara kpatara adịghị mma nke homonụ, nguzobe nke etuto ahụ na ihe ndị ọzọ yiri ya,
• ezigbo ịba ọcha n'anya.

Na mgbakwunye, ọgwụ a ekwesịghị ị byụ ọgwụ ụmụ nwanyị n’oge afọ ime na ịra nwa, ụmụaka na ụmụaka nọ n’agbata afọ 18, ndị agadi kariri afọ 65. N'iji nlezianya dị anya, ọ dị capsules dị mkpa maka ndị na-arịa àkwụkwụ ụgwọ ma ọ bụ na-enwekarị ọbara ọgbụgba.

Ndị mmadụ na-anwa ịgwọ oke ibu ma wepụsịa kilogram n'enyemaka nke ọgwụ slimming Meridia nwere ike iche ihu mmepe nke mmetụta ndị dị ka:

• tachycardia
• mmụba mgbali elu
• ọgbụgbọ
• afọ ntachi
• ọnụ kpọrọ nkụ
• imebi uto
• mgbu afọ na afọ,
• nsogbu nke urination
• nsogbu ehri ura ma obu ura kari ya,
• isi ọwụwa
• oge mgbu
• ọbara ọgbụgba
• belatara ikike
• akwara na mgbu
• Akpụkpọ ahụ na ntutu isi ya,
• nfụksị rhinitis
• ọzịza
• nkwarụ anya, wdg.

Vidiyo ndị metụtara

Nyocha nke ndị dọkịta banyere ọgwụ maka ịbelatalatalata ya na-enyelata ya Accinia, Meridia, Sibutramine, Turboslim na microcrystalline cellulose:

Ibu oke ibu oria, ogwu gha enye ya aka na nlebara anya. Iji felata, a ga - enyere mmadụ aka ọ bụghị naanị site na igwu egwuregwu na nri kwesịrị ekwesị, kamakwa site na ọgwụ siri ike. Meridia - ọgwụ eji eme nri ga-enye ezigbo nsonaazụ, mana ekwesịrị ị consumedụ ya nanị maka ịkwado dọkịta. Onwe-ogwu na ogwu a nwere ike kpasu ihe ndi mmadu kilogram na mmepe nke aru aru ike.

• Na-akwadokwa ọkwa shuga ruo ogologo oge
• Weghachi nrụpụta insulin nke pịkụl

Mụtakwuo. Ọ bụghị ọgwụ. ->

Omume ọgwụ

Omume ọgwụ ọgwụ - anorexigenic.

Nwee ọgwụgwọ maka oke ibu. Sibutramine na-egosipụta nsonaazụ ya na vivo n'ihi metabolites, nke bụ amines nke abụọ na nke mbụ.

Ọ na-egbochi ịlọghachi nke monoamines (nke bụ isi serotonin na norepinephrine) ma belata agụụ (jupụta mmetụta nke afọ ojuju) site na ịgbanwe (ịbawanye mmekorita mmekọrịta) nke noradrenergic nke etiti na ọrụ 5-HT ma na-abawanye thermogenesis site na arụmọrụ na-apụtakarị nke beta3-adrenergic ndị na-anabata ya. Ọ na-emetụta anụ ahụ adipose anụ ahụ.

Sibutramine na metabolites ya anaghị ahapụ monoamine ma ọ bụghị ndị na-egbochi MAO. Ha enweghị mmekọrịta maka ọnụ ọgụgụ buru ibu nke ndị na-anabata neurotransmitter, gụnyere serotonergic (5-HT1,5-HT1A, 5-HT1B, 5-HT2a, 5-HT2c), adrenergic (alpha1, alpha2, beta, beta1, beta3), dopaminergic (D1) , D2), muscarinic, histaminergic (H1), benzodiazepine na ndị na-anabata NMDA.

Ngosiputa nke ogwu Meridia

Nkwado nlekọta maka ndị ọrịa buru ibu na ọnọdụ ndị a:

• Ibu oke ibu na ahu aru nke 30 n'arọ / m2 ma obu karia,
• Ebu oke ibu na aru mmadu nke 27 n'arọ / m2 ma obu karia n’iru ihe ndi ozo n’enwe ike nihi oke, dika udiri oria abuo mellitus ma obu dyslipoproteinemia.

Ime na lactation

N'oge afọ ime, ekwesighi ị drugụ ọgwụ a, ebe ọ bụ ugbu a, ọnụọgụ ọmụmụ anaghị eju afọ nke ọma gbasara nchekwa nsonaazụ Meridia na nwa ebu n'afọ.

Womenmụ nwanyị toro afọ kwesịrị iji ọgwụ mgbochi ma na-a whileụ ọgwụ.

Ejila Meridia n'oge ara.

Mmekorita

N'otu oge eji sibutramine na ọgwụ ndị na-egbochi ọrụ CYP3A4 enzyme (ketoconazole, erythromycin, troleandomycin, cyclosporin) na-eduga na mmụba nke plasma mkpokọta nke sibutramine metabolites na mmụba nke obi site na 2.5 gbagwo ọ bụla n'otu minit na obere oge na-adaghị adaba ngbada ya na-aba.

Rifampicin, phenytoin, carbamazepine, phenobarbital, dexamethasone na ọgwụ mgbochi macrolide nwere ike ime ka metabolism nke sibutramine mee ngwa ngwa.

Iji otu oge eji ọgwụ eme ihe na-abawanye ọkwa nke serotonin neurotransmitter na plasma ọbara (nhọrọ serotonin reuptake inhibitors, sumatriptan, dihydroergotamine, analgesics - pentazocine, pethidine, fentanyl, ọgwụ antitussive - dextromethorphan), ihe egwu nke bero na-etolite.

Meridia anaghị emetụta mmetụta mgbochi mgbochi homonụ. Ihe omuma banyere nmekorita ọgwụ di iche iche metụtara ogwu nke ejiri obere oge.

Ka ị na-a itụ mmanya, ọ nweghị ịrị elu na mmetụta ọjọọ nke ndị ikpeazụ. Agbanyeghị, mmanya anaghị etinye ọnụ na usoro nri eji atụ aro mgbe ị na-ewere sibutramine.

Nsonaazụ

Ọtụtụ mgbe, nsonaazụ na-apụta na mmalite nke ọgwụgwọ (n'ime izu anọ mbụ). Udiri ha na oge ha ga-ebelata ka oge na-aga. Mmetụta ndị na-adịkarị nwayọ ma na-atụgharị. Iwu maka nyochawa etu esi akpata nsonaazụ: mgbe -> 10%, mgbe ụfọdụ 1-2%, adịkarịghị 145/90 mm Hg) (leekwa “Mmezi”).

Hyperthyroidism (mụbara ọrụ thyroid).

Ọrịa imeju siri ike.

Nnukwu akwara gbasara akwara.

Ọkpụkpụ hyperplasia Benign (ịmụba ka ọ dị na mmerụ ahụ).

Pheochromocytoma (akpụ akpụ-na-eto hormone nke adrenal gland).

Guzobere ọgwụ ogwu, ọgwụ na mmanya.

Ime na lactation.

Ekwesighi iji ọgwụ mgidia 15 mg mee ihe na ụmụaka na ndị nọ n’agbata afọ 18 na ndị agadi karịa 65 n’ihi enweghị ahụmịhe ụlọ ọgwụ zuru ezu.

Usoro onunu ogwu na nhazi

N’ime ya, ekwesịrị ịkpụkọ ya n’ụtụtụ, n’etinyeghị mmiri ọ drinkingụ andụ na mmiri ọ (ụ fluụ (otu iko mmiri). Enwere ike ị drugụ ọgwụ ahụ na afọ efu ma ọ bụ jikọta ya na nri.

Ọgwụ nke mbụ bụ capsule 1 nke Meridia 10 mg kwa ụbọchị. N'ime ndị ọrịa na-adịghị anabata ị doseụ ọgwụ a (ihe nlere bụ mbelata ogo nke anụ erughị 2 n'arọ n'ime izu anọ), dabere na ntachi obi dị mma, enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 15 mg. N'ime ndị ọrịa na-adịghị anabata ị takingụ ọgwụ mgbochi Meridia 15 mg (ihe nrịba ama bụ mbelata nke ịdị arọ anụ ahụ erughị 2 n'arọ n'ime izu anọ), a ga-akwụsị ịkwụsị ọgwụgwọ ọzọ na ọgwụ a.

Ọ bụrụ n’ikpefere ịpụ ọgwụ ahụ na ọgwụ nke 10 ma ọ bụ 15 mg, ịkwesighi ị aụ okpukpu abụọ, kama ịkwesịrị ịnọgide na-ewere ya dabere na usoro enyere n'iwu. Ọgwụ ekwesịghị ịga n’ihu ihe karịrị ọnwa 3 n’ebe ndị ọrịa anaghị anabatacha ọgwụgwọ nke ọma (oke belata nke erughị 5% nke ọkwa mbụ maka ọnwa 3 nke ọgwụgwọ). Agaghị aga n'ihu ọgwụgwọ ma ọ bụrụ na, na usoro ọgwụgwọ ọzọ, mgbe mmụba ahụ dị nwesịrị, onye ọrịa na-agbakwunye kilogram 3 ma ọ bụ karịa. Ogologo oge ọgwụgwọ ya na Meridia 10 ma ọ bụ 15 mg ekwesịghị gafere afọ 1 (data na arụmọrụ yana nchekwa nke ọgwụ ogologo oge adịghị).

N'oge ọgwụgwọ na Meridia, a na-adụ ndị ọrịa ọdụ ka ha gbanwee ụdị ndụ ha na omume ha nke na mgbe ha mechara ọgwụgwọ, ha na-ahụ na enwere ike iburu ibu ahụ (ma ọ bụrụ na achọpụtaghị ihe ndị a, mmụba ugboro ugboro na ahụ mmadụ na nleta dọkịta enweghị atụ).

A na-ahụ ntụzịaka a gbasara etu esi etinye ya na usoro ọgwụ ọnụọgụ ọgwụ dị ka ihe ziri ezi ruo mgbe dibịa na-ahụ maka ịga họpụtara gị usoro maka ị forụ ọgwụ ahụ. Iji rụpụta ihe dị mma, ịkwesịrị ịgbaso usoro usoro usoro onunu ogwu echekwara.

Dodoụbiga ya ókè

Data data ị onụbiga mmanya ókè nke sibutramine nwere oke. Amaghị ihe doro anya akara nke ịdoụbiga mmanya ókè, agbanyeghị, enwere ike ịtụle nkwupụta ọhụụ akpọrọ nke nsonaazụ ndị ọzọ.

Enweghị ọgwụgwọ a kapịrị ọnụ maka ịdoụbiga mmanya ókè na ọgwụ mgbochi ọrịa ụfọdụ. Ọ dị mkpa iji mepụta usoro izugbe iji nọgide na-eku ume, ọrụ nke akwara obi, na-akwado usoro ọgwụgwọ Symptomatic, lavage gastric na ojiji nke unyi arụ ọrụ. Site na ịba ụba ọbara mgbali na tachycardia, enwere ike ịnye ọgwụ mgbochi beta.

Nchedo nchekwa

A na-eji ya naanị n'ọnọdụ akọwapụtara nke ọma na ịkpachara anya pụrụ iche. Ndụmọdụ ọgwụ ike.

N'ime ndị ọrịa na-ewere Meridia, ọ dị mkpa ijikwa ọbara mgbali elu na ọnụego obi. N'ime ọnwa abụọ mbụ nke ọgwụgwọ, a ga-enyocha parampat ndị a kwa izu abụọ, ma kwa ọnwa. N'ime ndị ọrịa nwere ọbara mgbali elu (ọbara mgbali elu karịa 145/90 mm Hg), ekwesịrị ilebara paramini ndị a anya nke ọma na, ọ bụrụ na ọ dị mkpa, ọtụtụ mgbe. Ọ bụrụ mgbali ọbara n'oge ịtụle ugboro abụọ gafere 145/90 mm Hg. Ekwesiri ịkwụsịtụ ọgwụgwọ.

Ekwesịrị iji nlezianya mee ihe n'otu oge iji ọgwụ ndị na-abawanye oge QT (astemizole, terfenadine, amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol, cisapride, pimozide, sertindole, tricyclic antidepressants), na ọnọdụ na-aba na a na-ebuga naT na agha dịka hypokalemia na hypomagnesemia.

Mgbe ị na-eme nyocha ahụike oge niile banyere ọnọdụ onye ọrịa na-a theụ ọgwụ ahụ, ekwesịrị ị attentiona ntị na dyspnea na-aga n'ihu, mgbu obi na ọzịza n'ụkwụ, ọ bụ ezie na enweghi njikọ n'etiti ojiji nke Meridia na mmepe nke ọbara mgbali mbu.

Na oke ịkpachara anya nyere ndị ọrịa warawara.

Site na nlekọta pụrụ iche, ekwesịrị inye ndị ọrịa nwere ọrụ imeju dị nwayọ nwayọ nwayọ na-aga nfe (mmụba nke mkpokọta Sibutramine na plasma ọbara ga-ekwe omume).

Nyere na metabolites na-adịghị arụ ọrụ nke ọgwụ ahụ na-ewepụ akụrụ, na akpachapụ anya, ekwesịrị ị drugụ ọgwụ ahụ na ndị ọrịa nwere ọrụ akwara arụrụ aka nke ịdị nfe na-agafe agafe.

Ekwesịrị iji ya kpachara anya na ndị ọrịa nwere akụkọ banyere akwara ma ọ bụ mkparị (mgbatị akwara na-enweghị nchịkwa, yana njiri mara ụda).

Mmeghachi omume maka iwepụ ọgwụ (isi ọwụwa, agụụ ịba ụba) dị ụkọ. Enweghị data maka mmepe nke ọrịa ndọrọ ego, ọrịa mwepu ma ọ bụ ọgba aghara ọnọdụ.

N'oge ọgwụgwọ, ịkwesighi ị alcoholụ mmanya n'ihi mkpa ị followụ nri.

Iji nlezianya, a na-enye ya ọgwụ n'otu oge yana ọgwụ ndị na-abawanye ọbara mgbali elu na obi obi (gụnyere ọgwụ ndị a na-eji ụkwara, allergies na oyi).

Ọgwụ ndị na-eme ihe na -eme ihe n’usoro akwara ozi nwere ike kwụsịlata ọrụ ọgụgụ isi, ncheta na mmeghachi omume.Na agbanyeghi na ọmụmụ achọpụtabeghị mmetụta sibutramine na ọrụ ndị a, agbanyeghị kwesịrị ịkpachara anya mgbe ị na-edepụta ọgwụ ahụ maka ndị ọkwọ ụgbọ ala na ndị ọrụ ha metụtara itinye uche ha na-arịwanye elu.

Ntụziaka pụrụ iche

Ekwesịrị iji ọgwụ ahụ mee ihe naanị n'ọnọdụ ebe usoro niile iji belata oke ahụ adịghị arụ ọrụ (yabụ, ịbelata oke ahụ dị obere karịa 5 n'arọ maka ọnwa 3).

Ekwesịrị ịme ọgwụgwọ naanị dị ka akụkụ nke usoro ọgwụgwọ dị mgbagwoju anya iji belata oke ahụ n'okpuru nlekọta nke dọkịta nwere ahụmịhe bara uru n'ịgwọ oke ibu. Usoro ọgwụgwọ dị mgbagwoju anya gụnyere mgbanwe nri na etu esi ebi ndụ, nke dị mkpa iji nwee ike belata nhalata ahụ riri ahụ mgbe a kwụsịrị ọgwụ ọgwụ.

Oge ị takingụ ọgwụ ahụ kwesịrị inwe oke n'oge.

Ntụziaka Meridia maka ojiji, contraindications, nsonaazụ akụkụ, nyocha

Ọgwụ maka ọgwụgwọ oke ibu. Nkwadebe: MERIDIA®

Ọrụ umi nke ogwu: nwanne

Ntinye aka ATX: A08AA10KFG: Ọgwụ maka ọgwụgwọ nke nọmba ndebanye aha oke ibu: P Nke 012145/01 Registrationbọchị ndebanye: 02.26.06

Ndi nwe reg. acc.: ABBOTT GmbH & Co. KG

Mpempe mwepụta nke Meridia, nchịkọta ọgwụ na ihe mejupụtara

Capsules gelatin siri ike, ya na ahu edo edo na okpu anụnụ anụnụ, nke nwere "10", ihe ndị dị na capsules ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha. Kapusulu 1 okpu.

sibutramine hydrochloride monohydrate 10 mg Ndị ọkachamara: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, ink (isi awọ), quinoline edo edo. - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu 14 pcs.

- ngwugwu ọnya (1) - ngwugwu nke kaadiboodu 14 pcs. - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu 14 pcs. - agba dị iche iche (6) - ngwugwu nke kaadiboodu. Capsules siri ike gelatin, ya na ahụ ọcha na okpu na-acha anụnụ anụnụ, nke nwere "15", ihe ndị dị na capsules ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha. Kapusulu 1 okpu.

sibutramine hydrochloride monohydrate 15 mg Ndị na-eme ya: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, ink (isi awọ), odo odo quinoline. - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu 14 pcs.

- ngwugwu ọnya (1) - ngwugwu nke kaadiboodu 14 pcs. - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu 14 pcs. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Ọgwụ maka ọgwụgwọ oke ibu. Sibutramine bụ prodrug ma gosipụta nsonaazụ ya na vivo n'ihi metabolites (nke mbụ na nke amines) nke na-egbochi ịlọghachi nke monoamines (nke kachasị serotonin na norepinephrine).

Mmụba nke ọdịnaya nke neurotransmitters na synapses na-eme ka ọrụ nke ndị na-anabata 5-HT-serotonin na ndị na-anabata adrenergic, nke na-eme ka mmụba nke mmetụta zuru oke na mbelata ihe ndị na-eri nri, yana mmụba nke mmepụta ihe ọkụ.

Site na-arụ ọrụ na-anabata ndị na-anabata 3-adrenergic, sibutramine na-eme na anụ ahụ adipose.

Sibutramine na metabolites ya adịghị emetụta ntọhapụ nke monoamines, egbochikwa MAO, enweghị mmekọrịta maka ọnụ ọgụgụ dị ukwuu nke ndị na-anabata neurotransmitter, gụnyere serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), adrenergic (1) , 2, 3, 1, 2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine na ndị na-anabata NMDA.

Absorption, nkesa, metabolism Mgbe ị theụchara ọgwụ ahụ n'ime, sibutramine na-abanye ngwa ngwa site na ngwara nri. Oge erute Cmax nke sibutramine bụ awa 1.2.

Sibutramine fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju ya na ntinye nke CYP 3A4 isoenzyme na usoro nke mono- (dismethylsibutramine) na di-dismethyl (di-dismethylsibutramine) ụdị metabolites ndị na-arụ ọrụ (M1 na M2), yana site na hydroxylation na conjugation na usoro nke adịghị arụ ọrụ metabolites.

Mgbe otu mkpụrụ ọgwụ gharịrị ị atụ ọgwụ na 15 mg, Cmax M1 na M2 bụ 4 ng / ml (3.2-4.8 ng / ml) na 6.4 ng / ml (5.6-7.2 ng / ml), otu. Iri nri na-abawanye oge ịbịaru ma belata uru nke Cmax dismethyl metabolites site awa 3 na 30%, otu isi, anaghị emetụta ọnụahịa AUC nke dismethyl metabolites.

A na-ekesa ya ngwa ngwa na akwara. Ihe jikọrọ protein na sibutramine - 97%, M1 na M2 - 94%.

T1 / 2 nke sibutramine - awa 1.1, M1 - awa iri na anọ, M2 - awa 16. Ọ na - abụkarị akụkụ akụrụ n'ụdị metabolites na - adịghị arụ ọrụ.

na ụlọ ọgwụ pụrụ iche
Na ọdịda akụrụngwa, isi ọgwụ pharmokokinetic (Cmax, T1 / 2 na AUC) agbanweghị nke ukwuu.

Usoro onunu ogwu na uzo icho ogwu a

A na-etinye dose ahụ iche iche, dabere na ndidi na nrụpụta ọrụ ọgwụ Akara nke izizi bụ 10 mg. Site na arụmọrụ ezughi oke (mbelata n’arụ ahụ site n’ihe na-erughị 2 n'arọ n’ime izu anọ), ma dabere n’ezi ntachi obi, a ga-abawanye ọgwụ kwa ụbọchị ruo 15 mg.

Ọ bụrụ na, mgbe ị mụsịrị ọgwụ ahụ, ịdị irè nke ọgwụ ahụ ezughị ezu (ịta ahụ erughị ihe na-erughị 2 n'arọ n'ime izu anọ), ịga n'ihu na-ekwesịghị ekwesị. A ga-ewere okpokoro Meridia n'ụtụtụ na-ata ata ma na-a plentyụ ọtụtụ mmiri mmiri (iko mmiri). Enwere ike ị drugụ ọgwụ ahụ na afọ efu ma jikọta ya na nri.

Ekwesighi ịga n’ihu ihe karịrị ọnwa 3 n’ebe ndị ọrịa nọ n’oge a (ọnwa 3) enweghị ike nweta mbelata nke ahụ 5% site na ọkwa mbụ. Agaghị aga n'ihu ọgwụgwọ ma ọ bụrụ na, na ndabere nke usoro ọgwụgwọ Meridia, mgbe nwesịrị ịbelata ahụkarị, onye ọrịa na-agbakwunye kilogram 3 ma ọ bụ karịa.

Ogologo oge ọgwụgwọ Meridia ekwesịghị gafere afọ abụọ, ebe ọ bụ na enweghị data gbasara arụmọrụ yana nchekwa nke iji ogologo oge ị theụ ọgwụ ahụ.

Ọtụtụ mgbe, nsonaazụ na-apụta na mmalite nke ọgwụgwọ (n'ime izu anọ mbụ). Udiri ha na oge ha ga-ebelata ka oge na-aga. Mmetụta dị n'akụkụ, na-adịkarị nwayọ ma na-atụgharị mmetụta Mmetụta dị n'akụkụ, dabere na nsonaazụ na akụrụngwa, a na-egosi n'usoro ndị a: mgbe -> 10%, mgbe ụfọdụ - 1-10%, adịkarịghị -

Ọgwụ maka ọgwụgwọ nke oke ibu

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Capsules gelatin siri ike, ya na ahu edo edo na okpu anụnụ anụnụ, nke nwere “10” ihe dị n’ime ya, ihe ndị dị na capsules ahụ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha.

Ndị e mere: lactose monohydrate, microcrystalline cellulose, sillodọn sillodoliki, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, ink (isi awọ), odo odo quinoline.

7 pcs - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu 14 pcs. - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu 14 pcs. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.

14 pi. - ngwugwu mkpọ (6) - ngwugwu nke kaadiboodu.

Capsules gelatin siri ike, ya na aru di ocha na nke nwere ogho anụnụ anụnụ, nke nwere ihe ngbanye “15”, ihe di n’ime okpu agha bu ucha di ocha ma obu dika ucha di nfe.

Ndị e mere: lactose monohydrate, microcrystalline cellulose, sillodọn sillodoliki, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, ink (isi awọ), odo quinoline.

14 pi. - ngwugwu mkpọ (2) - ngwugwu nke kaadiboodu.

Pụtara maka igbochi agụụ

Ọgwụ Anorexigenic bụ otu ihe na - egbochi agụụ, na - emetụta sistemụ akwara. Enwere ebe agụụ na satiety na ụbụrụ. Ọgwụ ọjọọ na otu a nwere mmetụta na-akpali akpali na etiti izu ike, mana n'otu oge ahụ gbochie etiti agụụ. Mmetụta na sistemụ akwara na-esite na mkpokọta serotonin na norepinephrine na hypothalamus. N'ihi nke a, agụụ na-ebelata.

A na - eke ọgwụ ọgwụ Anorexigenic nke na - egbochi agụụ, nke na - eme ka usoro serotonergic na ndị ọrụ na - ejikọ.

Ngwurugwu mgbochi na nsonaazụ ya

Ekwesịrị iji ọgwụ Anorexigenic mee ihe dị ka dọkịta gwara ya, ebe ọ bụ na ọgwụ ndị a machibidoro ụfọdụ ndị. Kedu ndị ọrịa ekwesịghị ị drinkụ ego otu a:

• ya na obara mgbali elu
• thyrotoxicosis,
• ojoo neoplasms,
• akụkọ banyere nkụchi obi ma ọ bụ ọrịa strok,
• jọrọ njọ nke obi,
• Ọrịa mgbasa,
• glaucoma
• Akwụkwụ na-adọ.

Ọzọkwa contraindications bụ nsogbu nke ụbụrụ na usoro nje na sistemụ etiti, akwara na akụrụ ime, ehighị ụra na ịtụrụ ime.

N'ihe banyere oke ị ofụ ọgwụ ndị a, adịghị ike, ọgbụgbọ, vomiting, ọnụ akọrọ, afọ ọsịsa ma ọ bụ afọ ọsịsa, urination, oke iwe, oke ọgbụgba, mmụba ọbara, ị excessiveụbiga mmanya oke, mmeghachi omume nfụkasị ụdị urticaria ma ọ bụ ede ede Quincke.

Mgbe ihe mgbaàmà ndị dị otú ahụ pụtara, belata ọgwụ a ga-ebelata. Ọ bụrụ na mgbaàmà agbanwebeghị, ịkwesịrị ịkagbu ọgwụ ahụ ozugbo ma kpọtụrụ dọkịta iji dozie usoro ọgwụgwọ.

Ọgwụ "Meridia"

Ọnụahịa nke ngwá ọrụ a yiri ka ọ mara mma n'anya ọtụtụ. E kwuwerị, 700-800 rubles ma e jiri ya tụnyere ọgwụ ndị ọzọ yiri ya adịghị ọnụ. Mkpụrụ ọgwụ ndị a bụ ụzọ dị irè iji belata oke ahụ, nwee mmetụta ngwa ngwa. Ngwakọta ọgwụ bụ nke otu anorexigenic, na-eme ka enwe mmetụta nke iruju. Ọ na-egbochi reuptake nke serotonin, norepinephrine, dopamine, na-eme ka ọgwụgwọ ọgwụgwọ nke ọgwụ ahụ. A na-eji ya maka oke ibu na enweghị ọrịa pathology, na ọnụnọ nke metabolism na-egbu egbu yana ụdị ọrịa shuga 2.

"Meridia" dị na capsules gelatin nke 10 na 15 mg, iberibe 14 na 1 ngwugwu. Nkwekọ mgbochi ị takingụ ọgwụ ahụ bụ ntachi obi nke otu a, nsogbu ụjọ na akwara ozi, ọdịda nke anụ arụ n’ime ahụ, ọrịa nke akwara obi na akwara ọbara, ọrịa akụrụ, akwara, akwara thyroid.

Can nwere ike belata ahụ gị site na ị takingụ ọgwụ 1 nke 10 mg kwa ụbọchị. Ọ bụrụ na etinye ọgwụ ahụ nke ọma, enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 15 mg. Usoro ọgwụgwọ ekwesịghị ịbụ ihe karịrị afọ 1. Mbadamba nkume Meridia, enwere ike ịzụta ọnụ ahịa nke ihe dị ka 700 rubles maka capsu 14, site na ndenye ọgwụ.

Nke a bụ ọgwụ a jikọtara ọnụ n'otu oge na - egbochi etiti agụụ n'ihi metabolites ma mee ka etiti nwee afọ ojuju. A na-eji ọgwụ ahụ emechi ọgwụ capsule 1 kwa ụbọchị. Edere ọgwụ ahụ otu otu, dabere na ogo oke ibu na ọnọdụ ahụ niile. Ọtụtụ mgbe ọ bụ 10 mg. Ekwesịrị ị tabletsụ mbadamba okirikiri na-enweghị ihe ọwingụ washedụ, jiri ọtụtụ mmiri sachaa ya.

Ihe ngosiputa maka ojiji ha: oke ibu na enweghi oria a na-aputa aru, na onodu nke onye anakpo mmanu mmanu na oria nke abuo.

Ekwesighi iji ụmụ nwanyị dị ime na ndị na-actụ nwa, ndị ọrịa nwere akụkụ ụfọdụ arụ ọrụ. N'okwu a, achọrọ ntuziaka ọkachamara na ọkachamara. Edere ọgwụ a ka ọ na-eso usoro ahụike na ihe oriri.

Ọgwụ "Fepranon": ntuziaka maka ojiji

Nke a bụ ọgwụ anorexigenic nke ihe arụ ọrụ ya bụ ampepramone. Ọ na - eme ka etiti ngwụcha, na - egbochi etiti agụụ, na - eme ka ikpochapụ nke ihe ndị na - adịghị mkpa belata. Ọrụ nke ọgwụ ahụ gosipụtara onwe ya mgbe elekere 1 gachara, ọ na-eme ihe ruru awa 8, na-abanye nke ọma site na ụbụrụ ọbara na ihe mgbochi placental.

Ihe ngosi maka iji ogwu a bu oke ibu na oke ike nke metabolism n'ihi nsogbu nke homonụ. Site na usoro ọgwụgwọ thyroid, a na-eji ya na ọgwụ thyroid.

1 mbadamba ọgwụ ogwu nwere 25 mg nke ihe eji eme ihe. Ekwesịrị ị consumedụ ihe dị ka 80 mg kwa ụbọchị, ya bụ, 1 mbadamba 1-2 ugboro n'ụbọchị. Ikwesiri ị themụ ha ọkara ọkara tupu ị rie nri. Ogologo oge nnabata bụ ọnwa 2, enwere ike ịmeghachi ya mgbe ọnwa 3 gachara. A na-enye ọgwụ ahụ naanị site na ndenye ọgwụ.

N'ihe banyere oke mmiri Fepranon, obi ọgbụgba na iku ume ọsọ ọsọ, ihe ijuanya na ọdịda nwere ike ịpụta. Ọ bụrụ na ị theụrụ ọgwụ ahụ na Akwụkwụ na-adọ, ị nwere ike ịkpasu nkwarụ, yabụ ụdị ọrịa a, ị ga-amachi oriri ahụ.

Ọgwụ "Slimia"

Nke a bụ ụzọ maka ibulata oke, nsonaazụ ọgwụ nke emejupụtara ya na ekele maka sisutramine nọ n'ọrụ. Mmetụta anụ ahụ na-eme site na ịgbalite etiti afọ ojuju, belata agụụ na-esote iri nri. Ọzọkwa, ọgwụ ahụ na - enyere aka ime ka metabolism dị ukwuu na ngwa ngwa iwepụ ihe ndị na - egbu egbu n'ahụ ahụ.

A na - eji "Slimia" mee ihe maka oke ibu, oke ibu maka ọrịa shuga yana oke metabolism. A na-eji ọgwụ ahụ eme ihe n'ọnọdụ ndị dị otú a:

• na ụjọ na uche nsogbu,
• oke mmebi homonụ
• obi na akwara
• pathology nke imeju, akụrụ, thyroid gland,
• riri ahụ ma ọ bụ ahoụrụma,
• maka ndị gbara afọ 18
• womenmụ nwanyị dị ime na ndị na-actụ nwa.

Anabataghị nke ọma "ahụ" Slimia ". Nyocha banyere ifelata, gosipụtara na ọgwụ nwere mmetụta dị n'ụdị nri mgbari nri, isi ọwụwa, ụra, iro ụra oge niile na mmalite nke usoro ọgwụgwọ. Na ọnụnọ nke mgbaàmà ndị dị otú a, ị ga-agakwuru ọkachamara banyere iwepụ ọgwụ.

"Slimia" dị na mbadamba 10 na 15 mg, usoro ị theụ ọgwụ ahụ bụ 1 mbadamba kwa ụbọchị. Usoro ọgwụgwọ amalite na 10 mg, ọ bụrụ na mmetụta ahụ dị mma, mgbe ahụ, enwere ike ịba ụba nke ọgwụ ahụ gaa 15 mg ma nweta nsonaazụ dị mma na obere oge.

Mlọ ọgwụ

Sibutramine na-etinye obi gị dum na ngọngọ nri ma na-enwe nsonaazụ mbụ “mbụ” site na imeju. A hụrụ Cmax nke ọgwụ na plasma mgbe awa 1.2 gachara otu nchịkwa ọnụ nke 20 mg nke sibutramine.

Nkesa na metabolism

Sibutramine bụ nke CYP3A4 isoenzyme metabolized ka demethylated metabolites M1 na M2. Pharmacologically na-arụ ọrụ metabolites nke M1 na M2 ruru Cmax mgbe awa 3 gachara.

E gosiputara na kinetikị linear na-ewere ọnọdụ nke ọnụọgụ dị site na 10 ruo 30 mg, na enweghị mgbanwe na-adabere na T1 / 2, mana enwere mmụba na ị theụ ọgwụ ahụ na plasma ọbara kpọmkwem kwekọrọ na dose ahụ.

Site na iji usoro Css ugboro ugboro, metabolites M1 na M2 ruru n'ime ụbọchị 4, ma ihe fọrọ nke nta ka ọ bụrụ nchịkọta abụọ. Aclọ ọgwụ ọgwụ nke sibutramine na metabolites ya na ndị ọrịa buru ibu yiri nke ndị ọrịa nwere oke ahụ ha.

Njikọ nke sibutramine na metabolites M1 na M2 na protein plasma pụtara na ọkwa dị 97%, 94% na 94%, n'otu n'otu.

Agba nke mbụ nke sibutramine na metabolites M1 na M2 na-arụ ọrụ ya bụ metabolism na imeju. Ihe ndị ọzọ na-eme ka metabolites na-adịghị arụ ọrụ bụ ndị akụrụ ya, yana site na eriri afọ ya na oke 10: 1.

T1 / 2 nke sibutramine bụ awa 1.1, T1 / 2 nke metabolites M1 na M2 - 14 awa na awa 16, n'otu n'otu.

Pharmacokinetics n'ihe gbasara ọrịa

Ugbu a data dịchaghị ugbu a egosighi ịdị adị nke ọdịiche dị n'etiti ọgwụ na ọgwụ na ụmụ nwoke na ụmụ nwanyị.

The pharmacokinetics hụrụ na ndị ọrịa nwere ahụike siri ike (afọ nkezi afọ 70) yiri nke ahụ na ndị ọrịa na-eto eto.

Mkpesa ntaramahụhụ enweghị mmetụta na AUC nke metabolites M1 na M2 na-arụ ọrụ, ma e wezụga maka metabolite M2 n'ime ndị ọrịa nwere ọdịda akụrụngwa ọgwụgwụ na-eme usoro nyocha.Nwepu ha nke endingenous creatinine dị ihe dị ka ugboro abụọ karịa nke ndị mmadụ nwere ahụ ike (CL> 80 ml / min).

N'ime ndị ọrịa nwere oke ịba ọcha n'anya, AUC nke metabolites M1 na M2 nọ n'ọrụ 24% dị elu karịa otu ọgwụ sibutramine.

Ibu oke ibu na aru mmadu nke buru ibu (BMI) nke 30 n'arọ / m2 ma obu karia,

- Ebu oke ibu na BMI nke 27 n'arọ / m2 ma ọ bụ karịa na mgbakwunye na ụdị ọrịa shuga 2 na-arịa ọrịa shuga (na-abụghị insulin) ma ọ bụ dyslipoproteinemia.

Meridia: ntuziaka maka iji mbadamba ihe

Meridia - ọgwụ ọgwụ nwere sibutramine. Ihe a na - egbochi imeju afọ, na - egbochi abụba ịbanye na ichekwa ahụ.

A na-eji Capsules agwọ ọrịa oke ọ bụla ma mekwaa ka ndị ọrịa nwee ike ibu ibu. Ọgwụ dị irè, yabụ, ekwesịrị ị beụ ọgwụ ahụ n'okpuru nlekọta ahụike.

Ngwakọta na ụdị ntọhapụ

Meridia dị n'ụdị capsule. Otu ọgwụ nwere 10-15 mg nke sibutramine.

Nkọwapụta Meridia na ntuziaka - capsules gelatin nwere akụkụ abụọ nke edo edo na acha anụnụ anụnụ. N'ime mkpụrụ ọgwụ a na - acha ọcha.

Ihe ndị ọzọ mejupụtara nke slimming capsule Meridia:

• E 104
• Sds
• E 171
• E 132
• CMK
• E 572
• E 172
• Shellac
• Propylene glycol
• Mmiri ara ehi
• Gelatin
• E 322
• Dimethicone.

Na otu ọnya bụ 14 ma ọ bụ 28 capsules. Mbadamba ihe dị na ntuziaka ka etinyere n’ime igbe kaadiodu.

Ngwongwo ogwu

Sibutramine bụ ntụ ntụ nke dị ka mkpu. Na mbu, a na - emeghari akụrụngwa ahụ maka ịgwọ ọrịa uche, ma emesia ha malitere iji ọgwụ na ọgwụgwọ oke.

Ọgwụ Meridia na-emetụta metabolites, nke bụ amines nke abụọ. Sibutramine na-egbochi iweghachi nke neurotransmitters, nke mere na agụụ na-agafe na mmetụta nke satiety apụta.

Mmetụta ọgwụgwọ mgbe ejiri Meridia pụta na-eme n'otu ntabi anya, ebe ọ bụ na ihe ndị mejupụtara ọgwụ ahụ na-emetụta etiti saturation na ụbụrụ. Yabụ enwere mmetụta nke izu ụka ụgha, nke na-ebelata oke nri ị na-eri.

Njirimara ọgwụ ndi ozo nke ogwu:

• Lowers cholesterol, LDL, uric acid, triglycerides
• Na-eme ka lipoproteins dị elu
• O nwere mmetụta anorexigenic siri ike.
• Na-enyere aka ịmịcha lipids, gụnyere abụba aja aja
• Na-eme ka thermoregulation dịkwuo mma, n'ihi nke a na-akpali lipolysis ma na-eme ka usoro metabolic na-arụ ọrụ.

Meridia maka oke ibu nwere ihe ozo bara uru - microcrystalline cellulose. Ndị a bụ ajị anụ na -eme ka ụta.

MCC na-edozi usoro nri, na - ewepụ nsị, na - ewepu nsị ahụ n'ahụ. Ọzọkwa, ihe ahụ na-eju afọ eriri afọ, nke na-ebelata agụụ.

Ọnọdụ nchekwa nke ọgwụ ọgwụ Meridia

N’ebe nkụ kpọrọ nkụ, mgbe ọ na-adịghị ihe dị ka 25 Celsius.

Ekwela ka ụmụaka ghara iru ya.

Ndụ nchekwa nke ọgwụ Meridia bụ afọ 3.

Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Meridia - ọgwụ maka ibu belata, na-ezo aka n’otu ọgwụ ọgwụ na-achịkwa agụụ. Ọ bụ ụlọ ọrụ German bụ Knoll AG.

Ngwakọta na mmetụta nke ọgwụ ahụ "Meridia" n'ahụ ahụ

Emere Meridia na ntọala nke ihe dika sibutramine. Ọ na-egbochi mmetụta nke agụụ ma na-akpata satiety ngwa ngwa, nke mere na mmadụ na-eri obere kalori. N'etiti ndị na - emebu Meridia, enwere ihe dị ka lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate na ndị ọzọ.

Ọgwụ dị n'ụdị capsules gelatin siri ike nwere ahụ na-acha odo odo ma ọ bụ nke na-acha ọcha na okpu na-acha anụnụ anụnụ. Ihe dị n’ime capsules ndị ahụ bụ ntụ ntụ ọcha na-asọ asọ. Capsules nwere 10 mg ma ọ bụ 15 mg nke ihe na-arụ ọrụ. Ha dị ha na ngwugwu nke mbadamba 14 na 28.

Ere ọgwụ nri Meridia nwere mmetụta kpọmkwem na mpaghara ụbụrụ, na-ahụ maka ngụkọta oge ngwa ngwa na iwepu agụụ. Na mgbakwunye, ọgwụ a abụghị naanị na-ejikwa ma na-ebelata agụụ, kamakwa ọ na-eme ka nri mgbaze, belata kọlesterol, na-ahụkwa usoro metabolic niile na-eme ahụ mmadụ. Mgbe ị na-a Merụ Meridia, ahụ kwesịrị itinyekwu ume, n'ihi nke a na-ebelata oke ahụ.

Meridia capsules nwere ihe ndị dị mma dị mma:

• Enweghị nri siri ike na mgbatị ahụ na mgbatị ahụ, ị ​​theụ ọgwụ ahụ na-enye gị ohere ida nkezi 10% ma debe nsonaazụ ahụ ogologo oge.
• Tupu ọ pụta na shelf nke pharmacies, a nwalere ọgwụ n'ụlọ ọgwụ.
• Ihe eji mara mbadamba mbadamba bu ihe eji mara na odi mfe.
• Ndi Capsules ka akwadoro maka ire ya ma jiri ya mee ihe kariri mba iri abuo na isii.

Na mgbakwunye, ọgwụ Meridia na-arụ ọrụ na etiti ụbụrụ, na-ebelata agụụ ma na-eme ka usoro ngụgụ ahụ dị ngwa, ọ na-eme ka usoro lipolysis dị mma, n'ihi nke mkpụrụ ndụ abụba kewaa.

Iji mezuo nsonaazụ ọgwụgwọ a na-akpọ aha, a ga-a drugụ ọgwụ maka oke ibu Meridia ogologo oge. Ntuziaka ahụ na-egosi na usoro ọgwụ mbụ kwesịrị ịbụ 10 mg kwa ụbọchị. Ọ bụrụ na ọnwa nke mbụ na-efunari ibu nke ọma - ihe karịrị 2 n'arọ, ịkwesịrị ị na-ewere ya na usoro a. N'okwu ahụ mgbe ịdị arọ nke anụ ahụ belatara ihe na-erughị 2 n'arọ n'ọnwa mbụ, onye nrụpụta tụrụ aro ka iwelie onunu ogwu rue 15 mg nke ọgwụ kwa ụbọchị.

Otu usoro ọgwụgwọ bụ izu anọ. Ọ bụrụ na ị theụrụ ọgwụ ahụ ihe na-erughị ọnwa 3, ị gaghị enwe ike nweta ezigbo nsonaazụ, ebe ọ bụ na Meridia na-eme nwayọ ma nwee njiri mara ya. A ga-enweta nsonaazụ oke ibu karịa ọnwa isii ka mmalite nke capsules meridia malite.

Meridia slimming ọgwụ nwere ndị a contraindications:

• afọ ruo afọ 18
• oge ime na inye nwa ara,
• ihe karịrị afọ 65
• gbasara akụrụ na ọrịa imeju,
• ọrịa obi, ọbara mgbali elu, nsogbu ụbụrụ,
• na - ewere ụzọ ọzọ maka ifelata.

Ọtụtụ ihe analogues nke Meridia bụ ndị amaara, nke sibutramine nọ kwa. N'ime ọgwụ analogues bụ ọgwụ dịka Denfluramine, Dexfenfluramine, Fluoxitine.

Nsonaazụ, nsonaazụ, mmekọrịta

Mmetụta na-adịghị mma mgbe ejiri nwanneutramine mee ihe na-apụtakarị na ụbọchị iri atọ mbụ nke ọgwụgwọ. Dịka iwu, mgbe ọnwa gachara mbadamba nkume, mmeghachi omume na-agafe onwe ha.

Ọtụtụ mgbe, Meridia na-emebi traktị ahụ, nke na-egosipụta site na ndagide iwe, obi mgbawa, iwe iwe, ọgbụgbọ.

Mmetụta ndị ọzọ na-adịghị mma:

• CNS - migraine, xerostomia, nchegbu, nsogbu ịrahụ ụra, dysgeusia, vetrigo
• Ihe ntinye - ogharia, oria nettle, isi nchacha, igba obara
• Obi na arịa ọbara - ọbara mgbali elu, ọkụ na - ekpo ọkụ, ọgba aghara obi.

N'oge ụfọdụ, Meridia na-ebute nsonaazụ dị njọ karịa chọrọ ọgwụgwọ ọgwụgwọ. Ihe ojoo di otua ghari imechu onwe ya, ihe akwara nke oma, otinye okwute, akwara iba, plateillarotoxicosis na glomerular nephritis.

Ebe ọ bụ na iwere sibutramine na-emetụta ọrụ ụbụrụ, ọ nwere ike ịgbanwe ebe nchekwa na ọsọ nke mmeghachi omume, maka oge ịgwọ ọrịa, ị kwesịrị ịjụ ịchịkwa usoro ma ọ bụ njem dị mgbagwoju anya.

Emebebeghị oke nrịba nke Meridia. Ikekwe, n'ihe banyere ị aụ ọgwụ ọ ofụ ,ụ buru ibu, mmeghachi omume ọjọọ nwere ike ikwuru ya.

N'ihe banyere ịdoụbiga mmanya ókè, a naghị ebu ọgwụgwọ pụrụ iche. Ndị dọkịta na-atụ aro ka a na-ahụ maka ọrụ nke akwara vaskụla na usoro obi, iji hụ na ikuuru onye ọrịa ahụ ume. Ọ bụrụ na ọ dị mkpa, ịnwere ike were sorbent ahụ, duzie larịị gastric. Site na tachycardia ma ọ bụ ọbara mgbali elu, enwere ike iwere beta-blockers.

Mmekọrịta nke Meridia na ọgwụ ndị ọzọ:

• CYP3A4 enzyme inhibitors - ọnye obi na-ebili, ọdịnaya nke sibutramine metabolites na ọbara na-abawanye, oge QT na-agbatịkwu.
• Macrolides, glucocorticosteroids, ọgwụ ịrahụ ụra, ọgwụ mgbochi, ansamycins, normolytics, phenytoin - na - eme ka metabolitramine metabolism rụọ ọrụ.
• Ndị na - eme ihe mgbu siri ike, ọgwụ mgbochi nke ọgbọ 3, alfa-blockers, usoro ọgwụgwọ tryptamine - ohere ị intoụbiga serotonin na-abawanye.

Ihe analogues nke amara aha ogwu Meridia bu Reduxin na Goldline.

Emeputa - Ozone, Russia

Ọnụahịa - site na 1600 rubles

Nkọwa - a na - eji okpu akpukpo eji agwọ ọrịa oke na BMI nke 30 n'arọ / m2

Uru - na - enyere aka na oke ibu, na - ewepụ mmetụta agụụ

Cons - mmeghachi omume ọjọọ dị njọ na contraindications, ọnụahịa

Emeputa - Izvarino-Pharma, Russia

Ọnụahịa - site na 1200 ruo 3500 rubles

Nkọwa - a na - ewere capsules dabere na sibutramine na MCC maka oke ibu iji kpochapụ agụụ

Uru Ibu ibu na - adi ngwa ngwa, na - ebelata agụụ, adighi eri aru.

Cons - ọnụ ahịa, na - akpata akpịrị akpọ nkụ na nkụ iwe.

Onye na-achịkwa agụụ nri Meridia: ihe mejupụtara na ntinye maka ọgwụ a

Oriri na-ezighi ezi na enweghi mmega ahụ nwere ike ibute ọtụtụ kilogram na mmepe nke oke oke ibu.

N'ọnọdụ ụfọdụ, ọ gaghị ekwe omume ịnagide nsogbu yiri nke ahụ site na enyemaka nke egwuregwu na nri.

N'ọnọdụ ndị dị otú ahụ, ndị ọkachamara n'ihe banyere nri na-enye ndị ọrịa ha ọgwụ pụrụ iche iji belata oke ahụ.

Otu ọgwụ dị otú ahụ bụ Meridia. Mgbe ejiri ya n'ụzọ ziri ezi, ọgwụ a na-enye ezigbo ọfụma ma na-enyere ndị mmadụ aka ifelata n'enweghị mmerụ ahụike.

Ere ọgwụ nri Meridia na sibutramine na mejupụtara: drinkụọ ma ọ bụ ị notụghị?

Onye ọ bụla nke na-anwa ifelata ogologo oge maara: ihe na-enyere aka n'ezie, ọ na-emetụta ahụ ike. Imirikiti ụzọ dị nchebe adịghị arụ ọrụ. Yabụ, onye ọ bụla na-ekpebiri onwe ya ụzọ nke isi wee họrọ.

Mbadamba Meridia, nke gụnyere otu sibutramine, na-eme ka ị na-eche banyere isiokwu a. Ihe a, nke nnukwu asịrị nọ na-agbasa kemgbe ọtụtụ afọ ugbu a. Drink Toụ ma ọ bụ ị toụ ọgwụ a ka ọ dị gịrịgịrị?

Mbadamba nkume Meridia na igbe juru na igbe kaadi nwere ihe nmacha nke edoghi anya (di ocha, eweputara uzo di uku na ala). Nwere ike ịchọta ndị nrụpụta dị iche iche: ụlọ ọrụ Russia na nchegbu ndị German mepụtara ọgwụ ahụ.

Ọdịdị - capsules gelatin siri ike: edo edo (ịta ihe bụ isi ihe 10 mg) ma ọ bụ ahụ (15 mg) ahụ nwere okpu na-acha anụnụ anụnụ. Ime dị ọcha ntụ ntụ.

Nchịkọta nkịtị - iberibe 14 kwa ọnya, 2 blisters na 1 mkpọ.

Ihe mejupụtara ya gụnyere:

• sibutramine (ezigbo aha ya bụ hydrochloride monohydrate) na-arụ ọrụ dị ka ihe na-arụ ọrụ ike, ndị ọzọ niile na-aga dị ka inyeaka,
• sodium lauryl sulfate,
• microcrystalline cellulose,
• lactose monohydrate,
• colloidal silicon dioxide,
• stereta magnesium,
• gelatin
• titanium dioxide (E171),
• indigotine (E132),
• agba isi awọ
• ụcha edo edo quinoline (E104).

I kwesịrị ịghọta na Meridia bụ sịntetik, ọ bụghị ọgwụ okike nke nwere nsonaazụ ya niile. Ee, na sibutramine-nwere.

Na ọnọdụ sibutramine. Site na Jenụwarị 24, 2008, a gụnyere ihe ndị a na ndepụta nke ọgwụ ndị nwere ikike nke gọọmentị Rọshịa kwadoro. Yabụ, ire ndị nwere ya (gụnyere Meridia) bụ naanị ndị ọgwụ ka eji (na ntinye pụrụ iche) na ọ bụ naanị n'ụlọ ọgwụ.

Arụ ọrụ n'ahụ

Ihe omume nke mbadamba nkume a sitere na mmetụta psychotropic nke sibutramine, nke ha nwere. Kedu otu o si emetụta oke belata:

• akụrụngwa ọ na-ere ọgwụ bụ anorexigenic,
• na-ebelata agụụ (na-eme ka ahụ juju afọ ojuju) na ọnụọgụ nri riri,
• na-abawanye thermogenesis, n'ihi nke metabolism na lipolysis na-agbatị,
• emetụta anụ arụ
• na-abawanye itinye uche nke HDL n'ọbara ma na-ebelata ego nke triglycerides, cholesterol, uric acid, LDL.

Dabere na ọnụ ọgụgụ, ọtụtụ ndị oge a buru oke ibu n'ihi ndụ ibi ndụ na ị toụbiga mmanya ókè. Na nke a, Meridia bụ ezigbo ngwaọrụ maka ifelata, nke ga - enyere aka ịnagide ihe ndị na - akpata ya.

Sibutramine na-ebunye akara n’ ụbụrụ na anụ arụ juru, ọ naghịzi eri eri. Agụụ na-agụ agụụ, ma n'oge nri ị ga-eri nnukwu nri, ị gaghị achọ ya.

Nsonaazụ nwere ike iru kilogram 10 kwa ọnwa.

Ngosipụta ọgwụike maka ị Merụ Meridia bụ:

• oke ibu (ihe mbu) bu oke aru nwere ihe kariri 30 kg / m2,
• Ibu oke ibu na ahu mmadu na - ebido na 27 n'arọ / m2 ma oburu na ibu buru ibu nihi oke nri ma obu udiri oria nke II.

Echefula na ọgwụ bụ ọgwụ ndị erere ma resị ya nke ọma na ahịa ọgwụ. Mgbe ị na-agwa Meridia n'ihe ndị dị na ntanetị ma were ha n'onwe gị, na-enweghị ikikere dọkịta, ị ga-ebu ọrụ maka nsonaazụ niile ọ ga-esite na ya.

Ọnụ ahịa sitere na $ 24 ruo $ 52.

Nke a na-achọ ịmata ihe. Na nyocha, nke ọ bụ na 2010 ha kwụsịrị ire na mmepụta ọgwụ ọgwụ nwere Sibutramine (gụnyere Meridia), ndị nwere nsogbu na nrụgide na obi butere nsogbu na mbu. Ọ bụghị ihe ijuanya na mgbe njedebe nke nnwale ahụ, ọnọdụ ahụike ha kara njọ.