Kedu ihe bụ insulin resistance: akara na ọgwụgwọ

Nlegide insulin bu nzaghagharia ihe ndu ndu nke aru n’ahu na ihe oru insulin. Ọ baghị uru ebe insulin sitere, site na pancreas (endogenous) ma ọ bụ site na injections (exogenous).

Nchịkwa insulin na-abawanye ohere nke ọ bụghị naanị ọrịa shuga 2, kamakwa atherosclerosis, nkụchi obi, na ọnwụ na mberede n'ihi ịmịcha arịa ahụ.

Ihe insulin na-eme bụ ịchịkwa metabolism (ọ bụghị naanị carbohydrates, kamakwa abụba na protein), yana usoro mitogenic - nke a bụ uto, ịmụpụta mkpụrụ ndụ, njikọ DNA, njikọ mkpụrụ ndụ.

Echiche ọgbara ọhụrụ nke nguzogide insulin anaghị ejedebe n’ọrịa metabolism na nsogbu dị n’arụ ọrịa shuga nke 2. Ọ na - agụnye mgbanwe na metabolism nke abụba, protein, gene igosipụta. Karịsịa, nguzogide insulin na-eduga ná nsogbu nke mkpụrụ ndụ endothelial na-ekpuchi mgbidi nke arịa ọbara n'ime. N'ihi nke a, oghere nke arịa ahụ na atherosclerosis na-aga n'ihu.

Ihe mgbaàmà nke nguzogide insulin na nchọpụta ọrịa

Enwere ike inyo gị enyo na ị nwere ọgwụ insulin ma ọ bụrụ na mgbaàmà gị na / ma ọ bụ nyocha gosipụtara na ị nwere ọrịa metabolic syndrome. Ọ gụnyere:

oke ibu (ukwu),
ọbara mgbali elu (ọbara mgbali elu),
nyocha ọbara dị mma maka cholesterol na triglycerides,
ịchọpụta protin n’ime mmamịrị.

Oké ibu n’afọ bụ ihe mgbaàmà kachasị na-egbochi nguzogide insulin. N’ebe nke abụọ bụ ọbara mgbali elu akwara (ọbara mgbali elu). Obere oge, mmadụ anaghị enwe oke ibu na ọbara mgbali elu, mana nyocha ọbara maka kọlestrọl na abụba adịchaala njọ.

Testschọta nguzogide insulin site na iji ule bu nsogbu. N'ihi na itinye uche nke insulin na plasma ọbara nwere ike ịdị iche iche, nke a bụkwa ihe dị mma. Mgbe ị na-enyocha insulin plasma na-ebu ọnụ, ụkpụrụ dị site na 3 ruo 28 mcU / ml. Ọ bụrụ na insulin karịrị ọbara nkịtị, ọ pụtara na onye ọrịa ahụ nwere hyperinsulinism.

Mmụba insulin dị n'ọbara na-eme mgbe ọnya a na-amịpụta ya emegwara iji kwụọ ụgwọ ọgwụ insulin na-alụ. Nsonaazụ nyocha a na-egosi na onye ọrịa nwere nnukwu ihe ọghọm ụdị ọrịa shuga 2 na / ma ọ bụ ọrịa obi.

Accuratezọ kachasị mma maka ikpebi nguzogide insulin na-akpọ hyperinsulinemic insulin clamp. Ọ gụnyere nchịkwa ọbara ọbara nke insulin na glucose na-aga n'ihu ruo awa 4-6. Nke a bụ usoro na-agwụ ike, yabụ ọ na-adịkarịghị eji ya eme ihe. Ọ bụ n’uche ha ka ha na -ebu ule ọbara maka ọkwa insulin plasma.

Mmụta emere egosila na achọpụtara insulin:

10% nke mmadụ niile na-enweghị nsogbu metabolic,
n'ime 58% ndị ọrịa nwere ọbara mgbali elu (ọbara mgbali elu karịa 160/95 mm Hg),
n'ime 63% nke ndị nwere hyperuricemia (serum uric acid karịrị 416 mmol / l n'ime ụmụ nwoke na karịa 387 mmol / l n'ime ụmụ nwanyị),
Na 84% nke ndị nwere abụba ọbara (triglycerides karịrị 2.85 mmol / l),
n'ime 88% nke ndị nwere oke cholesterol dị mma (n'okpuru 0.9 mmol / l n'ime ụmụ nwoke na n'okpuru 1.0 mmol / l n'ime ụmụ nwanyị),
na 84% nke ndị ọrịa nwere ụdị shuga 2,
66% nke ndị nwere nsogbu glucose na-arụ ọrụ.

I mee ule ọbara maka cholesterol - achọla cholesterol zuru ezu, mana iche “dị mma” na “jọrọ njọ”.

Otu insulin si achịkwa metabolism

Dị ka ọ na-adịkarị, mole insulin na-ekekọta ndị na-anabata ya n’elu mkpụrụ ndụ n’arụ, abụba, ma ọ bụ akwara umeji. Mgbe nke a gasịrị, autophosphorylation nke nnabata insulin na ntinye nke tyrosine kinase yana njikọ ya na ntinye nke insulin receptor 1 ma ọ bụ 2 (IRS-1 na 2).

Ihe ụmụ irighiri IRS, n’aka nke ya, na-arụ ọrụ phosphatidylinositol-3-kinase, nke na-akpali ntụgharị nke GLUT-4. Ọ bụ a na - ebu glucose n’ime sel site na akpụkpọ ahụ. Usoro dị otú a na-enye nkwado nke metabolic (njikọ glucose, glycogen synthesis) na mitogenic (njikọta DNA) nke insulin.

Ihe ndị na-akpali glucose site na sel akwara, imeju na akwara adipose,
Nmekorita nke glycogen na imeju (nchekwa nke “ngwa ngwa” glucose na idobere),
Jide amino acid site na sel,
Nlekọta DNA
Nlekọta protin
Ngwakọta na-abụ abụba
Igafe Ion.

Lipolysis (mmebi nke anụ ahụ adipose na ntinye nke ọdụdụ abuba n'ime ọbara),
Gluconeogenesis (mgbanwe nke glycogen na imeju na glucose n'ime ọbara),
Apoptosis (mbibi nke mkpụrụ ndụ).

Mara na insulin na-egbochi ndakpọ nke anụ ahụ adipose. Ọ bụ ya mere, ọ bụrụ na ọkwa nke insulin na ọbara dị elu (hyperinsulinism bụ ihe na-eme ugboro ugboro na insulin na-eguzogide), mgbe ahụ ịdalata oke bụ ihe siri ike, ọ fọrọ nke nta ka ọ ghara ikwe omume.

Mkpụrụ ndụ ihe nketa na-akpata nguzogide insulin

Nmegide insulin bu nsogbu nke otutu mmadu. A kwenyere na ọ bụ mkpụrụ ndụ ihe nketa kpatara ya bụ mmalite nke mmalite. N'afọ 1962, a kọwapụtara ya na mmiri ọgwụ insulin na-arụ ọrụ bụ ihe nchekwa ndụ n'oge agụụ. Maka na ọ na - eme ka abụba dị n’ahụ n’ahụ n’oge nri hiri nne.

Ndị ọkà mmụta sayensị agụụ ụmụ oke na-ata ụta ogologo oge. Ndị mmadụ lanarịrịnụ bụ ndị a chọpụtara na ha nwere ọgwụ mgbochi insulin site n'ọmụmụ. Ọ bụ ihe nwute, na ọnọdụ ọhụụ, usoro insulin na-eguzogide “na-arụ ọrụ” maka mmepe nke oke ibu, ọbara mgbali elu na ụdị shuga nke 2.

Nnyocha e mere egosiwo na ndị ọrịa nwere ọrịa shuga 2dị nke abụọ nwere ntụpọ mkpụrụ ndụ ihe nketa na mbufe ozi mgbe ha jikọtara insulin na onye nnabata ha. Nke a ka a na-akpọ ntụpọ postreceptor. Nke mbu, imeghari onye na - ebugharị glucose GLUT-4 na - akpaghasị.

N'ime ndị ọrịa nwere ụdị ọrịa shuga 2, ahụrụ nke ụdị mkpụrụ ndụ ndị ọzọ na-enye metabolism nke glucose na lipids (abụba). Ndị a bụ mkpụrụ ndụ ihe nketa maka glucose-6-phosphate dehydrogenase, glucokinase, lipoprotein lipase, fatty acid synthase na ndị ọzọ.

Ọ bụrụ na mmadụ nwere usoro izipu mkpụrụ ndụ ihe nketa ga-arịa ọrịa shuga 2, mgbe ahụ ọ ga-amata ma ọ bụ ghara ịkpata ọrịa metabolic na ọrịa shuga. Ọ dabere na ụdị ibi ndụ. Ihe ndị kachasị n’ihe ndị dị ize ndụ bụ ihe oriri na-edozi ahụ, karịchaa oriri nke carbohydrates nụchara anụcha (sugar na ntụ ọka), yana mmega ahụ dị ala.

Kedu ihe bụ uche nke insulin na anụ ahụ dị iche iche

Maka ọgwụgwọ nke ọrịa, nnabata insulin nke akwara na anụ ahụ adipose, yana mkpụrụ ndụ imeju, bụ ihe kachasị mkpa. Ma ogo insulin iguzogide anụ ahụ ndị a bụ otu? Na 1999, nnwale gosiri na ọ dịghị.

Nọmalị, iji belata 50% nke lipolysis (nkwụsị abụba) na anụ ahụ adipose, ị nweta insulin n'ime ọbara erughi 10 mcED / ml zuru ezu. Maka nnabata 50% maka ịhapụ glucose n'ime ọbara site na imeju, ihe dị ka 30 mcED / ml nke insulin n'ime ọbara ahụ ka achọrọ. Na iji mee ka mmụba glucose site na anụ ahụ akwara site na 50%, ịchọrọ insulin n'ọbara nke 100 mcED / ml ma dị elu.

Anyị na-echetara gị na lipolysis bụ mmebi nke anụ ahụ adipose. Ọrụ insulin na-egbochi ya, dịkwa ka imeju nke imeju si mepụta glucose. Na -emeju glucose umeji n’ọkpụkpụ site na insulin, n’aka nke ya, na-aba ụba. Biko rịba ama na n'ụdị ọrịa shuga abụọ nke ọrịa mellitus, ụkpụrụ ndị akọwapụtara nke insulin chọrọ n'ọbara ka agafee n'aka nri, yabụ, na-abawanye na nguzogide insulin. Usoro a na-amalite ogologo oge tupu ọrịa shuga egosipụta onwe ya.

Mmetụta anụ ahụ anụ ahụ na insulin na-ebelata n'ihi na mkpụrụ ndụ ihe nketa, yana nke kachasị - n'ihi ụdị ndụ na-adịghị mma. Na njedebe, mgbe ọtụtụ afọ gasịrị, akwara kwụsịrị ịnagide oke nchegbu. Mgbe ahụ, ha na-achọpụta ụdị ọrịa shuga “ezigbo”. Ọ nwere uru dị ukwuu na onye ọrịa ahụ ma ọ bụrụ na ịmalite ọgwụgwọ nke metabolic syndrome dị ka o kwere omume.

Kedu ihe dị iche n'etiti nguzogide insulin na ọrịa metabolic syndrome

I kwesịrị ịmara na a na-ahụkwa ọgwụ insulin n’etiti ndị mmadụ nwere nsogbu ahụike ọzọ na-etinyeghị na echiche nke “metabolic syndrome”. Nke a bụ:

polycystic ovary n'ime ụmụ nwanyị,
ụkwara akwara na-adịghị ala ala
ọrịa na-efe efe
glucocorticoid ọgwụ.

Nlegide insulin na-ebido n’oge ịtụrụ ime, na-agafekwa ịmụ nwa. Ọ na-adịkarị elu site na afọ. Ọ dabere na ụdị ndụ onye agadi na-ebi, ma ọ ga-ebute ụdị ọrịa shuga 2 na / ma ọ bụ ọrịa obi. Ke ibuotikọ emi “Mme usiene udọn̄ọ ke n̄kani owo”, afo oyokụt ata nti ifiọk.

Nchịkwa insulin bụ ihe na-akpata ụdị shuga 2

N'ime ụdị ọrịa shuga abụọ nke ọrịa mamellitus, nguzogide insulin nke akwara akwara, imeju na anụ ahụ na-adị n’ịkpa bụ ihe kachasị mkpa n’ụlọ ọgwụ. N'ihi nnwere onwe nke insulin, glucose dị ala na-abanye ma “na-anyụ ọkụ” n'ime mkpụrụ ndụ akwara. N'ime imeju, maka otu ihe ahụ, arụ ọrụ nke glycogen na glucose (glycogenolysis) na-arụ ọrụ, yana njikọta glucose site na amino acids na “ngwaọrụ ndị ọzọ” (gluconeogenesis).

Egosiputa insulin iguzogide anụ ahu adi adi n’ime ya bu na ihe ndi mmadu na - eme ka insulin na - ebelata. Na mbu, ihe ndi ozo bu mmeputa insulin na-abawanye. N'ọgwụgwụ nke ọrịa ahụ, abụba na-abawanye glycerin na abụba abụba n'efu. Ma n’oge a, ifelata adịghị eweta ọ joyụ dị ukwuu.

Glycerin na ọdụdụ abụba na-abanye umeji, ebe a na-emepụta lipoproteins dị ntakịrị ala. Ndị a bụ ururu emerụ ahụ nke etinyebere n'ahụ mgbidi nke akwara ọbara, na atherosclerosis na-aga n'ihu. Iri oke glucose, bụ́ nke na-apụta n'ihi glycogenolysis na gluconeogenesis, na-abanyekwa n'ọbara.

Nchịkwa insulin na akara nke metabolic syndrome n’ime mmadụ ogologo oge mmepe nke ọrịa shuga mellitus. N'ihi na insulin iguzogide afọ ndị a afọ site na imeju ọgwụ insulin nke na-eme ka ọgwụ ọgwụ insulin na-emeju nke ukwuu. N'ọnọdụ dị otú ahụ, a na-achọpụta ịbawanye ụba nke insulin n'ime ọbara - hyperinsulinemia.

Hyperinsulinemia nwere glucose ọbara nkịtị bụ akara nke insulin na-eguzogide ma na-egbochi mmepe nke ụdị shuga 2. Ka oge na-aga, mkpụrụ ndụ beta nke a na-eme anwụ anaghịzi anagide ibu iji kwụọ ụgwọ nguzogide insulin. Ha na - emepụta insulin na-erughị ala, onye ọrịa ahụ nwere shuga dị elu na ọrịa shuga.

Nke mbu, usoro mbu nke insulin insulin na enwe, i.e., mwepu nke insulin n’ime obara n’ime nzaghachi maka ibu nri. Secrezọ insulin a na-ahụkarị na ya si arụ ọrụ gabiga ókè. Mgbe ọ̀tụ̀tụ̀ shuga dị n'ọbara rịa elu, ọ na-emekwu ka insulin na-eme ka anụ ahụ sie ike ma na-egbochi ọrụ nke mkpụrụ ndụ beta n’ime ihe nzuzo nke insulin. A na-akpọ usoro a maka ọrịa shuga “akpịrị glucose.”

Nlegide insulin na nsogbu obi

A maara na na ndị ọrịa nwere ọrịa shuga 2, ọrịa obi na-abawanye site na ugboro 3-4, ma e jiri ya tụnyere ndị na-enweghị nsogbu metabolic. Ugbu a, ọtụtụ ndị ọkà mmụta sayensị na ndị na-eme ihe kwenyesiri ike na insulin na-eguzogide ọgwụ, yana ya, hyperinsulinemia bụ nnukwu ihe dị ize ndụ maka nkụchi obi na ọrịa strok. Ọzọkwa, ihe ize ndụ a esiteghị na onye ọrịa ahụ ebutela ọrịa shuga ma ọ bụ na ọ kpatara.

Kemgbe 1980s, nnyocha gosipụtara na insulin nwere mmetụta atherogenic kpọmkwem na mgbidi nke arịa ọbara. Nke a pụtara na ngwugwu atherosclerotic na ịbelata oghere nke arịa ahụ na-aga n'ihu n'okpuru ọrụ insulin n'ime ọbara na-agabiga n'ime ha.

Insulin na-ebute mmụba na ịkwaga akwara mkpụrụ ndụ dị mma, njikọ nke lipids n'ime ha, ịba ụba nke fibroblasts, ịgbalite usoro coagulation ọbara, yana mbelata nke ọrụ fibrinolysis. Ya mere, hyperinsulinemia (mmụba nke insulin n'ọbara n'ihi nguzogide insulin) bụ ihe dị mkpa na-ebute mmepe nke atherosclerosis. Nke a na - eme ogologo oge tupu ụdị ọrịa shuga 2 dị na onye ọrịa.

Ihe omumu gosiputara nmekorita doro anya n'etiti ogo insulin iguzogide na ihe puru iche maka oria obi. Nmegide insulin na-eduga n'eziokwu ahụ:

oke ibu nke na-aba n’ime afọ,
profaịlụ cholesterol ọbara na-akawanye njọ, na plasta si “cholest” cholesterol na –ewu n'ahụ mgbidi arịa ọbara,
enwere ike inye ọbara ọgbụgba n'ime arịa na-abawanye,
mgbidi carotid artery na-ebuwanye ibu (lumen nke akwara akwara).

E gosipụtara mmekọrịta a kwụsiri ike ma ndị ọrịa nwere ụdị ọrịa shuga 2 na ndị mmadụ n'otu n'otu enweghị ya.

Ọgwụ insulin na-eguzogide ọgwụ

Effectivezọ dị mma isi gwọọ nguzogide insulin n'oge mmalite nke ụdị shuga 2, yana ọ ka mma tupu ịmalite, bụ iji nri na-egbochi carbohydrates na nri gị. Iji bụrụ nke ziri ezi, nke a abụghị ụzọ isi gwọọ nguzogide insulin, kama ọ bụ naanị ijikwa ya. Nri carbohydrate nwere obere ume na nguzogide insulin - a ga-agbado ya na ndụ.

Mgbe ụbọchị 3-4 nke nri ndị na-egbochi insulin na-eguzogide ọgwụ, ọtụtụ ndị na-achọpụta ọganihu na ọdịmma ha. Mgbe izu isii ruo asatọ, ule gosiri na kọlestrọl “dị mma” n'ime ọbara na-ebili ma “ihe ọjọọ” ahụ daa. Ọkwa ọkwa nke triglycerides n'ime ọbara na-adaba na nkịtị. Nke a pụtara na ihe ọghọm nke atherosclerosis belatara ọtụtụ ugboro.

Enweghị ọgwụgwọ ọ bụla ugbu a maka nguzogide insulin. Ndị ọkachamara n'ihe banyere mkpụrụ ndụ ihe nketa na ihe ọmụmụ banyere ndụ na-arụ ọrụ na nke a. You nwere ike ijikwa nguzogide insulin nke ọma site na ịgbaso nri nwere obere carb. Nke mbụ, ịkwesịrị ịkwụsị iri nri carbohydrates nụchara anụcha, ya bụ, shuga, ihe ndị na-atọ ụtọ na ngwaahịa ntụ ọka ọcha.

Site na nguzogide insulin, metformin (siofor, glucophage) na-enye nsonaazụ dị mma. Jiri ya na nri, ọ bụghị kama ya, buru ụzọ jụọ dọkịta gị gbasara ị takingụ ọgwụ. Kwa ụbọchị, anyị na-agbaso akụkọ banyere ọgwụgwọ ọgwụ mgbochi. Ọkpụkpụ mkpụrụ ndụ ihe ochie na microbiology na-arụ ezigbo ọrụ ebube. Ma enwere olile anya na n’afọ ndị na-abịanụ, ha ga-enwe ike dozie nsogbu a. Ọ bụrụ na ịchọrọ ibu ụzọ mara, denye aha na akwụkwọ akụkọ anyị, ọ bụ n'efu.

Gịnị bụ nguzogide insulin

Oge nguzogide insulin rụtụ aka enweghi ike ị nweta sel nke ịba na insulin homonụ. Ike nke mkpụrụ ndụ ejikọtara homonụ na, yabụ, meghachi omume na akara aka ya na-eduga n'eziokwu ahụ na mkpụrụ ndụ anaghị anabata glucose.

Nke a na-eduga mụbaa glucose ọbara na, n'otu oge ahụ, ọkwa ahụ na-eto ọbara insulinn'ihi na enweghi ike iji homonụ nke ọma.

Gịnị kpatara ọnọdụ a?

Ihe na - akpata ya: oke oke ikuku nke insulin ma ọ bụ ntụpọ mkpụrụ ndụ ihe nketa

Metabolism nke glucose njikọ chiri anya emeputa insulin site na mkpụrụ ndụ beta nke pancreas. Mkpụrụ ndụ nke ahụ anyị nwere ndị na - anabata insulin nke dị na sel ahụ, nke na - enye anyị ohere ime ka usoro nke ibugharị yana ịmịkọrọ shuga site na mkpụrụ ndụ.

Ka osila dị, n’ihe ụfọdụ, sel na - emeghachighi insulin:

Ulinmịpụta Ọgwụ insulin: mgbe enwere oke insulin site na akwara n'ihi ọtụtụ ebumnuche, dịka ọmụmaatụ, ị excessụbiga shuga ọbara ugboro ugboro n'ihi ihe oriri na-adịghị mma.
Ọkpụkpụ mkpụrụ ndụ ihe nketa: mgbe ndị na - anabata ihe dị n’elu sel nwere ntụpọ nke mkpụrụ ndụ ihe ma ọ bụ ọgwụ mgbochi ọgwụ bibie ya.

Resistancedị insulin nke A ma ọ bụ Bdị B

Ọ bụ ezie na iguzogide insulin na-eduga otu mmetụta, i.e. enweghi ike ịnye insulin, nwere ike ịdị n'ụdị abụọ dị iche iche:

Pịnye Nchịkwa Insulin: nke kachasị, jikọtara ya na ọrịa dịka metabolic syndrome, ụdị shuga nke afọ 2 na ụmụ oke polycystic.
Resistancedị nguzogide B insulin: udiri oria a na - adighi ahu, nke anaghi agha. Otu njirimara bụ ọnụnọ ọgwụ mgbochi megide ndị na - anabata insulin.

Kedụ ókè ikike insulin dị n'ime ya?

Ule na usoro nyocha maka nchoputa

Nkịtị larịị bara uru ọbara insulin bụ 6-29 μl / ml. A na-eme nchọpụta nyocha nke nguzogide insulin site na iji usoro nyocha dị iche iche, ụlọ nyocha ma ọ bụ ọmụmụ ọgwụ.

Banyere ihe omumu, ihe banyere ihe ndi mmadu na - eguzogide insulin bu:

Nnwale Hyperinsulinemic-Euglycemic: na-enye gị ohere ịlele ole glucose chọrọ iji kwụọ maka mmụba insulin na-enweghị hypoglycemia.
Ule nnabata insulin: a na-eme nyocha ụlọ ọgwụ site na nnwale pụrụ iche.

Ọ bụ ezie na ụzọ ndị a ziri ezi, ha siri ike iji maka ebumnuche ụlọ ọgwụ, ha na-ejikarị maka ebumnuche sayensị.

N'ime usoro ịgwọ ọrịa kwa ụbọchị, kama nke ahụ, a na-eji usoro ndị a:

Nlekota Ndidi: Ndị nwere oke ibu ma ọ bụ nwee eriri ukwu karịa nke ha na-enwekarị nwere ike ịnwe insulin.
Oru ibu nwale: a rụrụ site na ịhazi njupụta nke glucose na ọbara n'ime afọ efu na mgbe ị nwesịrị glucose 75 g n'ime.
Usoro insulin: ịba n’arụ shuga insulin, n’afọ na-enweghị isi ma mgbe nri gachara. A na-eme ya nke ọma ya na ọnụ ọnụ glucose dị n'ụkpụrụ.
Ndepụta HOMA: usoro dị mkpa maka ịtụle nguzogide insulin bụ ntanye HOMA (Homeostasis Model Assessement).

Ihe ndị nwere ike ime ka ịbawanye mgbochi nke insulin

Ihe na - akpata insulin na - emegide ihe dị iche iche, mana oge niile na - eduga enweghị ike sel ịza insulin homonụ:

Oriri na erimeri: erighị nri na-edozi ahụ, nke gụnyere ị ofụ ọtụtụ shuga dị mfe, ihe ọetsụetsụ na nri ndị nwere abụba, ndụ mgbakasị ahụ na enweghị mmega ahụ zuru oke bụ ọnọdụ ndị na-ebute mmepe nke ọrịa metabolic, oke ibu na iguzogide insulin.
Jenetik: N'ọnọdụ ụfọdụ, enwere ntụpọ mkpụrụ ndụ ihe nketa na ndị na - anabata insulin, nke, n'ihi ya, anaghị arụ ọrụ nke ọma. Canfọdụ ọrịa oria, dịka Donohue syndrome na Rabson-Mendenhall syndrome, bụ ndị na-ekpebi iguzogide insulin n’ime ụmụaka, ka atụtara.
Ihe omumu: Usoro oria na - eme oria na - eme ka ogwu di ndu ma obu ndi n’aru megide ndi na - anabata insulin. Ruo ugbu a, usoro ndị a aghọtachaghị nke ọma, mana ha na-eduga na ụdị nguzogide ọgwụ ins nke B.
Hormones: Disordersfọdụ nsogbu endocrine, dịka ọrịa Cushing ma ọ bụ acromegaly, na-ekpebi mmepe nke nguzogide insulin, ebe ọ bụ na ọtụtụ homonụ dị ka GH (hormone hormone), cortisol na glucocorticoids, nke bụ insulin antagonists.
Ogbo: Orsfọdụ akpụ akpụ, dịka pheochromocytoma na glucagon, na-ekpebi nrụpụta nke homonụ buru ibu, ndị na - emegide insulin.
Ọgwụ: Iji corticosteroids ma ọ bụ homonụ na-eto (GH) nwere ike ibute iguzogide insulin.

Okwesiri iburu n'uche na ọrịa ụfọdụ nwere ike ịbụ ihe kpatara ya, n'otu oge ahụ, nsonaazụ nke nguzogide insulin, dị ka anyị ga-ahụ na ngalaba na-esonụ.

Ọrịa metụtara nkwụghachi insulin

Ihe mgbaàmà kachasị nke nguzogide insulin bụ ụba glucose ọbara, i.e. hyperglycemia na mmụba nke ọkwa insulin (hyperinsulinemia), nke enwere ike ijikọ ya na mgbaàmà dịka ike ọgwụgwụ, iro ụra, na adịghị ike n'ozuzu.

Agbanyeghị, enwere ọtụtụ mgbaama ndị ọzọ na-emetụta ihe ga-esite na ya, ma oge ụfọdụ bụ ihe kpatara nsogbu a, nke na-ekpuchi akụkụ na usoro dị iche iche, karịchaa:

Site na usoro ọmụmụ: Ọnọdụ insulin na-eduga na ọnọdụ nke hyperandrogenism, ya bụ, ụba ụba homonụ nwoke na nwanyị. Nke a nwere ike iduga infertility, amenorrhea, na nsogbu dịka ọrịa akwara polycystic. Ọ bụrụ na insulin na-eguzogide ọgwụ n’oge afọ ime, ọ nwere ike ibute ime ọpụpụ, ọkachasị na ọnwa mbụ nke ịtụrụ ime. Menopause, ihe dị oke egwu maka mmepe nke ọrịa metabolic, nwekwara ike ibute mgbochi insulin, ebe enwere mgbanwe na metabolism n'ihi enweghị estrogen.
Metabolism Acid Acid: nguzogide insulin na-ebute mgbanwe na metabolism nke ọdụdụ abụba. Nke kachasị, ọnụọgụ abụba na-eme n’onwe ya na-abawanye, nke a na-abịa site na oke glucose na ọbara. Nke a na - ekpebi mmetụta dị iche iche na ọkwa nke adipose anụ ahụ: mkpo nke acid abụba na - eduga n'inweta ibu na itinye abụba na oghere nke ime, oke imeju, na ọkwa akwara na - ebulite ohere nke ịmalite atherosclerosis.
Ọkpụkpụ akụrụngwa: Nnyocha insulin nwere ike ibute nsogbu obi, dịka ọbara mgbali elu nke kpatara mmụba nke njigide sodium n'ihi hyperinsulinemia, nguzobe oghere nke abụba na akwara na-ebelata ọbara na-erute n'obi.
Ahụ ọnya: Otu njirimara nke nguzogide insulin bu mmepe nke ọnya akpukpo anakpo acanthosis, nke na - eme ka akpukpo akpukpo ahu di njo, bu ihe kari. Agbanyeghị, usoro nkwurịta okwu na nguzogide insulin ka amabeghị.
Ọrịa shuga 2dị 2: Ihe kachasị na-ebute insulin iguzogide. Ọ na-egosipụta onwe ya dị ka ihe mgbaàmà oge ochie nke ọrịa shuga, dịka akpịrị ịkpọ nkụ, urination ugboro ugboro, ike ọgwụgwụ, ọgba aghara.
Ihe ndị ọzọ rụpụtara: N'ime nsogbu ndị ọzọ nke nguzogide insulin, ọdịdị nke ihe otutu, nke nwere njikọ chiri anya nke polycystic ovary syndrome na hyperandrogenism, ntutu isi, na-esokwa na mmụba nke mmepụta androgens.

Ntị! A na - ejikọ insulin na - egbochi insulin ọrịa ndị ọzọọ bụ ezie na abụghị esite na ya pụta. Dịka ọmụmaatụ, mmegide insulin na-ejikọkarị ya na oke ibu na ọrịa thyroid, dị ka hypothyroidism, nke na-eme ka ọ kwụsịlata na metabolism ma na-eme ka ọ dịkwuo ike ịkpakọba abụba, na nguzogide insulin na-akpatakwa ọdịda akwara na-adịghị ala ala na atherosclerosis.

Kedu otu esi agwọ ọgwụ nguzogide insulin?

A na-emeso ọgwụ na ọgwụ ndị na-enyere aka ịlụ ọgụ a ọgụ, karịsịa nri site na nri, ọgwụ, ma ọ bụ enweghi mmetụta homonụ na-akpata.

Iji mata otu esi emeso ọgwụ mgbochi, ịkwesịrị ịgakwuru dọkịta nke ga-enye ndụmọdụ maka ọgwụgwọ ahụ kachasị adaba, dabere na ihe kpatara nsogbu ahụ. Anyị na-enyekwa gị ndụmọdụ!

Na-egbochi iguzogide insulin: nri na ọrụ ya

Iri nri mgbe nile bu otu n’ime ihe ndi mmadu n’enwe nsogbu na iguzogide insulin jikọtara ya na ọrịa metabolic. N'ezie, nri ndị na-adịghị mma na nri ndị buru ibu na oke ibu na-akpata bụ ihe mbụ na-akpata nguzogide insulin.

N'ihi ya, ifelata dị oke mkpa maka ọgwụgwọ. Yabụ, enwere ụfọdụ ngwaahịa ana-ahọrọ karịa na ndị ọzọ kwesịrị izere.

Ngwaahịa ahọrọ: Ihe oriri nwere obere glycemic index, ya bụ, nke na-eji nwayọ na-ewelite ọ̀tụ̀tụ̀ shuga dị n’ọbara, n’ihi ya na -echilata agụụ n’oge, bụ ihe kacha mkpa. Dịka ọmụmaatụ, ntụ ọka, ọka zuru oke, ngwaahịa mmiri ara ehi nwere obere abụba, mmiri ara skim. Anụmanụ na azụ ka masịrị gị.
Ihe oriri iji zereA: Ekwesịrị izere nri niile na - eme ka mmụba dị mma na glucose ọbara, dị ka achịcha, shuga dị mfe, achịcha na pasta si na ntụ ọka. Ihe oriri nwere ike ịmị, ihe ọ carbonụ carbonụ carbonated, ihe ọholicụholicụ na-aba n’anya, na ụfọdụ akwụkwọ nri glycemic modular dị ka nduku na karọt ga-amachibidokwa.

Ihe di nkpa mmega ahụ kwesịrị ekwesịrụrụ kwa ụbọchị ma ọ dịkarịa ala ugboro atọ n'izu iji kwalite ibu ibu.

Herbal tii 1

1 teaspoon nke ahịhịa bluuberi,
1 teaspoon nke mkpụrụberry
30 g nke ukpa doo
1 nju mkpụrụ akụ.

Na ngwakọta kwesịrị inye n'ime esi mmiri nkeji iri, mgbe ahụ, ẹdụk ma drunkụọ mmanya dịkarịa ala ugboro atọ n'ụbọchị.

Ihe kpatara ụdị ọrịa shuga 2

Ihe mgbaàmà nke metabolic syndrome n’ime mmadụ ogologo oge mmepe nke ọrịa shuga. N'ihi na insulin iguzogide afọ ndị a afọ site na imeju ọgwụ insulin nke na-eme ka ọgwụ ọgwụ insulin na-emeju nke ukwuu. N'ọnọdụ dị otú ahụ, a na-achọpụta ịbawanye ụba nke insulin n'ime ọbara - hyperinsulinemia.

Hyperinsulinemia nwere glucose ọbara nkịtị bụ akara nke insulin na-eguzogide ma na-egbochi mmepe nke ụdị shuga 2. Ka oge na-aga, mkpụrụ ndụ beta nke pancreas kwụsịrị ịnagide ibu ahụ, nke dị ọtụtụ oge karịa nke nkịtị. Ha na - emepụta insulin na-erughị ala, onye ọrịa ahụ nwere shuga dị elu na ọrịa shuga.

Nsogbu Cardiovascular

Ihe omumu emere gosiputara ihe mmekorita doro anya nke oma n'etiti insulin na ngafe ya na oria obi. Nmegide insulin na-eduga n'eziokwu ahụ:

oke ibu nke na-aba n’ime afọ,
profaịlụ cholesterol ọbara na-akawanye njọ, na plasta si “cholest” cholesterol na –ewu n'ahụ mgbidi arịa ọbara,
enwere ike inye ọbara ọgbụgba n'ime arịa na-abawanye,
mgbidi carotid artery na-ebuwanye ibu (lumen nke akwara akwara).

E gosipụtara mmekọrịta a kwụsiri ike ma ndị ọrịa nwere ụdị ọrịa shuga 2 na ndị mmadụ n'otu n'otu enweghị ya.

Herbal Tea 3

Ihe eji eme ya:

Leaves Tbsp. Sage akwụkwọ,
15 g nke eucalyptus akwukwo,
35 g nke ukpa akwukwo
35 g bluuberi akwụkwọ.

Jiri:

Gwakọta ahịhịa ndị a, hapụ maka nkeji iri ma drinkụọ ugboro atọ n'ụbọchị.

Ọgwụ Ọgwụ Maka Nchịkwa Insulin

Ọgwụ ọgwụ na-achọ ibelata shuga ọbara na, yabụ, kpochapụ hyperinsulinemia.

Ọgwụ ị na-eji bụ hypoglycemic nke edere n'ime ị nwere ike ịchọpụta:

Biguanides: Metformin bụ nke ụdị a, ọ dịkwa mma karịsịa n'ihe metụtara insulin iguzogide oke ibu, ebe ọ na-ebelata mmetụta agụụ.
Glinids: ọgwụ ndị a na-eji wedata shuga ọbara mgbe anyị risịrị nri, n'etiti anyị ka anyị ga-ewepụ otu n'ime azụ.
Sulfonylurea: na-eme ka mkpụrụ ndụ nke insulin dịkwuo elu na insulin, mana enweghị ike iji ya mee ihe mgbe niile, n'ihi na ha nwere ike ịkpata mgbanwe n'ọkwa nke protein protein. Glycvidone, glipizide na glibenclamide so na mpaghara a.

Anyị nwara imepụta onyonyo niile nke nguzogide insulin. Usoro ogwu a n'oge ikpe dị oke egwu, yabụ mgbochi dị oke mkpa.