Mikstard® 30 NM Nkeji ogologo oge insulin na-agwakọta ya na insulin na-adị mkpụmkpụ

Nkwụsịtụ maka nchịkwa subcutaneous, 100 IU / ml

1 ml nke ọgwụ nwere

ike - mkpụrụ ndụ ihe nketa insulin mmadụ 3.50 mg (100 IU) 1,

ndị na-ebu ụzọ: zinc chloride, glycerin, phenol, metacresol, sodium hydrogen phosphate dihydrate, protamine sulfate, hydrochloric acid 2 M ngwọta, sodium hydroxide 2 M ngwọta, mmiri maka injection.

1 Ọgwụ ahụ nwere insulin mmadụ na-eme 30% na 70% isofan-insulin

Nkwụghachi ọcha ahụ, mgbe ọ na-eguzo ọtọ, na-agbanwe ka ọ bụrụ onye na-enweghị atụ, enweghị agba ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke enweghị agba na ọkwa ọcha. A na - eji nwayọ nwayọ were weghachite ihe omume.

Ngwongwo ogwu

Mlọ ọgwụ

Ndụ ọkara nke insulin n'ọbara bụ ọtụtụ nkeji, ya mere, profaịlụ nke ọgwụ nwere insulin na-ekpebi naanị site na njimara ya. Ogologo oge nke ihe insulin na-eme bụ n'ihi nzere, nke dabere na ọtụtụ ihe (dịka ọmụmaatụ, na insulin insulin, usoro na ebe nlekọta, ọkpụrụkpụ nke subcutaneous abụba oyi akwa na ụdị ọrịa shuga mellitus). Yabụ, ọgwụ ọgwụ insulin nke gọọmentị na-enwe mgbanwe dị iche iche na-emetụta mmadụ.

A na - enweta insulin na plasma nke kachasị (Cmax) n'ime awa 1.5 ruo 2.5 mgbe nchịkwa subcutaneous gasịrị.

O nweghị ihe akpọrọ ihe na-egbochi protein amasara ahụ, ewezuga ọgwụ mgbochi insulin (ọ bụrụ na ọ dị).

A na-ewepụ insulin mmadụ site na ọrụ nke insulin protease ma ọ bụ enzymes na-eme ka insulin na-ehichapụ ya, na ikekwe sitekwa n'ọrụ protein disulfide isomerase. Echere na na molekul nke insulin mmadu nwere otutu saịtị nke cleavage (hydrolysis), agbanyeghị, ọ nweghị nke metabolites guzobere n'ihi nsachapụ adịghị arụ ọrụ.

Ndụ ọkara (T½) kpebisiri ike ịnwe nzere site na anụ ahụ dị n'okpuru ala. Ya mere, T½ bu ihe ozo banyere nnabata, karie ihe ozo banyere iwepu insulin na plasma (T½ nke insulin n’aru obara bu obere oge). Mmụta emere gosiri na T½ bụ ihe dịka awa 5-10.

Mlọ ọgwụ

Mikstard® 30 NM bụ insulin nke na-arụ ọrụ abụọ na-arụpụta nke ihe omimi ihe omimi nke DNA site na iji Saccharomyces cerevisiae. Ọ na - emekọrịta otu onye na - anabata ihe n'ụsọ akpụkpọ ahụ cytoplasmic nke mkpụrụ ndụ ma mepụta ogige nnabata insulin. Site na mmezi nke biosynthesis cAMP (na sel na abụba) ma ọ bụ, na-abanye n'ime sel (akwara), insulin-receptor complex na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ enzymes isi (hexokinase, pyruvate kinase, glycogen synthetase, wdg). A na-eme ka mbelata ọbara glucose ọbara site n’ịbawanye na ebufe ọbara n’ime akwara, ịba ụba na nnabata nke anụ ahụ, mkpali nke lipogenesis, glycogenogenesis, njikọ protein, mbelata ọnụego glucose mepụtara site na imeju, wdg.

Mmetụta nke ọgwụ Mikstard® 30 NM na-amalite n'ime ọkara otu elekere mgbe nchịkwa gasịrị, a na-egosipụta mmetụta kachasị n'ime awa 2-8, ebe ngụkọta oge nke ime ihe dị ka awa 24.

Usoro onunu ogwu na nhazi

A na-enyekarị insulin ọgwụ jikọtara ọnụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị ma ọ bụrụ na achọrọ ngwakọta nke nsonaazụ ngwa ngwa na ogologo oge.

A na-ahọrọ ọ̀gwụ nke ọgwụ n’otu n’otu, na-eburu n'uche mkpa ndị ọrịa. Dị ka ọ dị, chọrọ insulin dị n'etiti 0.3 na 1 IU / kg / ụbọchị. Needchọrọ insulin kwa ụbọchị nwere ike ịdị elu karịa na ndị ọrịa nwere nguzogide insulin (dịka ọmụmaatụ, n'oge oge uto, yana na ndị ọrịa na-ebu oke ibu), na-agbadata na ndị ọrịa nwere ọgwụ insulin na-apụtakarị ihe.

Ọ bụrụ na ndị ọrịa na-arịa ọrịa shuga na-enweta njikwa glycemic kachasị mma, mgbe ahụ nsogbu nke ọrịa shuga na ha, dịka iwu, ga-apụta ma emesịa. N'akụkụ a, mmadụ kwesịrị ịgbalịsi ike ịkwalite njikwa metabolic, karịchaa, ha na-elezi anya nke ọma glucose dị n'ọbara.

A na-enye ọgwụ ahụ nkeji iri atọ tupu nri ma ọ bụ nri nwere carbohydrates.

Maka nhazi dị n'okpuru ala. N'ọnọdụ ọ bụla, ekwesịrị iji ọgwụ insulin kwụsịtụrụ. Mikstard® 30 NM na-abụkarị nkebi subcutaneously na mpaghara nke mgbidi afọ. Ọ bụrụ na nke a dabara adaba, mgbe ahụ injections nwekwara ike ịme n’apata ụkwụ, mpaghara gluteal ma ọ bụ mpaghara mpaghara akwara dị n’ubu (subcutaneously). Site na ntinye ọgwụ a na mpaghara mpaghara mgbidi afọ, a na-enweta mmịpụ ngwa ngwa karịa iwebata ya na mpaghara ndị ọzọ. Perrụpụta ntụtụ n’akpụkpọ ahụ na-ebelata ohere ịbanye n’olu. Okwesiri igbanwe ebe igba ogwu n’etiti mpaghara anatomical iji belata nsogbu nke lipodystrophy.

Ntụziaka maka iji Mikstard® 30 NM, nke a ga-enyerịrị onye ọrịa ahụ.

Ejila Mikstard® 30 NM:

Na nfuli insulin.

Ọ bụrụ na enwere ihe nfụkasị (hypersensitivity) na insulin mmadụ ma ọ bụ na ihe ọ bụla mejupụtara Mikstard® 30 NM.

Ọ bụrụ hypoglycemia amalite (shuga dị ala).

Ọ bụrụ na echeghị insulin n'ụzọ ziri ezi, ma ọ bụ kpụọ ya oyi

Ọ bụrụ na okpu nchebe na-efu ma ọ bụ tọghe. Kalama ọ bụla nwere okpu plastik na-echebe ya.

Ọ bụrụ na insulin apụtaghị na-acha ọcha na urukpuru mgbe agwakọchara.

Tupu iji Mikstard® 30 Nm:

Lelee akara ahụ iji jide n'aka na ị na-eji ụdị insulin dị mma.

Wepu okpu nchebe.

Etu ị ga-esi jiri ọgwụ ọjọọ Mikstard® 30 NM

Ọgwụ Mikstard® 30 NM bụ nke emere maka ọchịchị subcutaneous. Ya adịkwala mgbe ị ga-eji insulin emechi ma ọ bụ intramuscularly. Gbanwee oge ntanetị niile na mpaghara anwansi iji belata ihe mgbaze na ọnya na saịtị ahụ. Ebe kachasị mma maka injers bụ: aka, ikpere ma ọ bụ ubu.

Dị njikere ijiri sirinji insulin na-etinyere ọ̀tụ̀tụ̀ iji tụọ ọ̀tụ̀tụ̀ ahụ na nkeji ihe.

Dọrọ ikuku banye ntụtụ na ọnụego insulin chọrọ chọrọ.

Ngwa ngwa tupu ị theụ ọgwụ ahụ, tụgharịa vial ya n'etiti ọbụ aka gị ruo mgbe insulin na-acha ọcha ma nwee urukpuru. A na-emeghachite mbugharị ọzọ ma ọ bụrụ na ọgwụ nwere ọnụ ụlọ ahụ.

Tinye insulin n'okpuru anụahụ.

Jide agịga n'okpuru anụ ahụ maka ọ dịkarịa ala 6 sekọnd iji jide n'aka na a na-edozi ọgwụ insulin nke ọma.

Ọrịa concoitant, nke na-efe efe ma na-efe efe, na -emekarị ahụ insulin nwere ahụ. Ọ ga-adị mkpa imeghari dose ma ọ bụrụ na onye ọrịa ahụ nwere ọrịa ndị akụrụ, akụrụ, ọrụ akwara, pisis gland ma ọ bụ azụ gland.

Mkpa maka ịhazigharị dose nwekwara ike ibili mgbe ị na-agbanwe mmega ahụ ma ọ bụ nri ndị ọrịa na-emebu. Imezi dose mgbe ị na-ebufe onye ọrịa n’otu ụdị insulin na nke ọzọ.

Nsonaazụ

Mmeghachi omume na-adịghị mma nke a hụrụ na ndị ọrịa n'oge ọgwụgwọ na Mikstard were 30 NM bụ nke dabere na ntanetị nke ukwuu ma bụrụ n'ihi usoro ọgwụ insulin.

Ihe ndị a bụ ụkpụrụ nke ugboro ole nke mmeghachi omume ọjọọ akọwapụtara n'oge ule ụlọ ọgwụ, nke e lere anya dịka o jikọtara ya na iji ọgwụ Mikstard® 30 NM. Ekpebisiri ugboro ole a dị ka nke a: ugboro ugboro (≥1 / 1,000 ruo

Ọnọdụ nchekwa nke ọgwụ Mikstard ® 30 NM Penfill ®

Mee ka ụmụaka ghara iru.

nkwusioru maka ochichi nke subcutaneous nke 100 IU / ml - afọ 2.5.

Ejila oge ngwụcha ụbọchị egosipụta na ngwugwu ahụ.

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Asambodo ndenye aha Mikstard ® 30 NM Penfill ®

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Mikstard 30 NM bụ insulin na-arụ ọrụ ugboro abụọ. A na-enweta ọgwụ ahụ site na njikọ akụ na ụba nke DNA na-eji ụdị Saccharomycescerevisiae. Ọ na - emekọrịta ihe na ndị na - anabata mkpo akpụkpọ ahụ, n'ihi nke insulin-receptor complex na-apụta.

Ọgwụ na-emetụta usoro dị n'ime sel, site na ọrụ nke biosynthesis na imeju na mkpụrụ ndụ abụba. Na mgbakwunye, akụrụngwa na-akwalite nzuzo nke enzymes ndị dị mkpa, dị ka glycogen synthetase, hexokinase, pyruvate kinase.

A na --ebelata shuga ọbara site na mmegharị akwara intracellular, nnabata a kwalitere na nnabata glucose dị mma site na uru ahụ. Emeghachila ọrụ nke insulin mgbe ọkara otu elele gasịrị. A na-enwetakwa ntinye uche kachasị elu mgbe awa 2-8 gachara, oge ọ ga-eweta bụ otu ụbọchị.

Omume ọgwụ, ihe ndị na-egosi na contraindications

Mikstard bụ insulin nke nwere ihe abụọ nwere nkwarụ nke isofan-insulin na-arụ ọrụ ogologo oge (70%) yana insulin na-arụ ọrụ ọsọ ọsọ (30%). Ọkara ndụ nke ọgwụ si n'ọbara na-ewe ọtụtụ nkeji, ya mere, profaịlụ ọgwụ a bụ nke njirimara nke nnabata ya.

Usoro itinye uche na-adabere n’ihe dị iche iche. Yabụ, ụdị ọrịa, usoro onunu ogwu, mpaghara na ụzọ nlekọta, yana oke ọkpukpu anụ ahụ dị.

Ebe ọ bụ na ọgwụ a na-egbu mmụọ ka ọ dị, ọ na-anabatakarị ngwa ngwa. A na-enweta ntinye uche kachasị na ọbara mgbe awa 1.5-2 gachara mgbe nchịkwa sc.

Nkesa nke insulin na-aputa mgbe o jikọtara ndi na protein ndi plasma. Ewezuga ya bụ protein ndị na-agagharị n'ihu ya nke na-apụtaghị.

A na-ekpochapụ insulin mmadụ site na enzymes na-emebi emebi ma ọ bụ ihe mkpuchi insulin, yana, ikekwe, site na protein disulfide isomerase. Na mgbakwunye, achọpụtara ebe hydrolysis nke ụmụ irighiri insulin dị. Agbanyeghị, metabolites guzobere mgbe hydrolysis anaghị arụ ọrụ bayoloji.

Ọkara ndụ nke arụ ọrụ na-adabere na ntinye ya na anụ ahụ dị n'okpuru ala. Oge nkezi bụ awa 5-10. N'otu oge, anaghị emepụta ọgwụ ọgwụ maka atụmatụ metụtara afọ.

Ihe ngosiputa maka ojiji nke insulin Mikstard bu udiri 1 na udiri oria abuo, mgbe onye oria eweputala iguzogide mbadamba shuga.

Contraindications bụ hypoglycemia na hypersensitivity.

Ihe mbu kwesịrị iburu n’obi bụ na usoro ọgwụgwọ kwesiri ka dọkịta nye ya n’otu n’otu. Onu ogugu nke insulin maka onye nwere oria di oria bu 0-1-1 IU / n'arọ nke ibu ibu nwata - 0.7-1 IU / kg.

Ma n’ịkwụghachi ọrịa ahụ, usoro ọgwụgwọ ahụ dị mkpa iji belata usoro onunu ogwu, ma ọ bụrụ n’ịba oke ibu na oge ntozu, mmụba nwere ike ịdị mkpa. Ọzọkwa, mkpa nke homonụ ga-eji nke ọrịa ịba ọcha n'anya na akụrụ na-ebelata.

Ekwesịrị iji ọgwụ ndị gbara agba ọkara tupu ọkara eri nri nwere carbohydrate. Agbanyeghị, ọ dị mma icheta na a bụrụ na ịwụsị nri, nrụgide na ịba ụba na-emega ahụ, a ga-agbanwe usoro ịha ahụ.

Tupu ịmalite insulin ọgwụ, ọtụtụ iwu kwesịrị ịmụ:

Anaghị anabata nkwụsị.
A na-eme irighiri mmiri dị n'okpuru mgbidi nke apata ụkwụ, apata ụkwụ, na mgbe ụfọdụ, na olu dị iche iche n'ubu ma ọ bụ n'ọkpụkpụ ụkwụ.
Tupu okwu mmeghe, ọ bụ ihe amamihe dị na ya igbu oge ikpuchi akpụkpọ ahụ, nke ga-ebelata ohere nke ngwakọta na-abanye n’uru ahụ.
Should ga-amarakwa na site na iji ọgwụ s / c nke insulin banye na mgbidi nke afọ, ịmịkọrọ ya na-eme ngwa ngwa karịa iwebata ọgwụ na mpaghara ndị ọzọ.
Iji gbochie mmepe nke lipodystrophy, a ghaghị ịgbanwe saịtị ntụtụ mgbe niile.

A na - eji insulin Mikstard n’ime karama eji eme ihe puru iche. Agbanyeghị, tupu ị theụ ọgwụ ahụ, a ga-ekpochapụ stopa roba. Mgbe ahụ, a ga-ete ime karama ahụ n’etiti nkwụ ruo mgbe mmiri dị n’ime ya ga-abụ edo ọcha.

Mgbe ahụ, a na-adọrọ ego ikuku n'ime sirinji, nke dị ka usoro insulin si elekọta. A na-ewebata ikuku n’ime vial ahụ, a na-ewepụpụ agịga ahụ na ya, a na-ewepụ ikuku n’agha ahụ. Na-esote, ị ga-elele ma ọ batara ọgwụ ahụ n'ụzọ ziri ezi.

A na-eme ọgwụ insulin dị ka nke a: ijide akpụkpọ ahụ na mkpịsị aka abụọ, ịkwesịrị ịkụ ya ma jiri nwayọ wepụta ihe ngwọta. Mgbe nke a gasịrị, agbanye ya agịga n'okpuru anụahụ ihe dịka sekọnd 6 ma wepụ ya. N'ọnọdụ ọbara, a ga-eji mkpịsị aka gị tee ebe ntụtụ gị.

Ọ dị mma ịmara na karama ahụ nwere okpu na-echebe plastic na-ewepụ tupu ngwa insulin.

Agbanyeghị, ọ ga-ebu ụzọ lelee otu esi ejikọ mkpuchi ahụ na ite ahụ, ọ bụrụ na ọ na-efu efu, mgbe ahụ, a ga-akpọghachi ọgwụ ahụ n'ụlọ ahịa ọgwụ.

Nyocha nke ndị dọkịta na ọtụtụ ndị ọrịa mamịrị na-agbadata n'eziokwu na ọ kachasị adaba iji Mixtard 30 FlexPen.

Nke a bụ mkpịsị insulin na-eji ọgwụ ọnụọgụ na-ahọrọ, nke ị nwere ike ịhapụta usoro onodu ogwu site na nkeji 1 ruo 60 na mmụba nke otu nkeji.

Ejiri Flespen jiri agịga NovoFayn S, ogologo ya kwesịrị ịdị ruo 8 mm. Tupu ojiji, wepu okpu ahụ na sirinji ma gbaa mbọ hụ na homonụ ahụ nwere opekata mpe ọ bụla iri abụọ na abụọ. Na-esote, a ga-akpachapụrụ mkpịsị ọrịre dị ka ugboro 20 ruo mgbe nkwụchi ahụ ga-abụ igwe ojii ma dị ọcha.

Mgbe nke ahụ mechara, ịkwesịrị ịme usoro ndị a:

A na-agwọ akpụkpọ anụ roba na-egbu egbu.
Ewepu akara nchekwa na agịga.
Ọkpụkpụ na-emerụ na Flexpen.
A na-ewepụ ikuku n'ime kadi.

Iji hụ na iwebata otu usoro iji gbochie ikuku ịbanye, ọtụtụ ihe dị mkpa. Ekwesịrị ịtọ mkpụrụ abụọ na pen sirinji. Na-esote, ijide Mikstard 30 FlexPen ya na agịga, ị kwesịrị iji nwayọ wee pịa mkpịsị aka gị ugboro ole na ole, ka ikuku wee na-agbakọta n'akụkụ ya.

Mgbe ahụ, ijide mkpịsị sirinji n'ọnọdụ ziri ezi, pịa bọtịnụ mmalite. N'oge a, onye na-ahọrọ ọgwụ kwesịrị ịgakwuru efu, na dobe ngwọta ga-apụta na njedebe nke agịga. Ọ bụrụ na nke a emeghị, mgbe ahụ ịkwesịrị ịgbanwe agịga ma ọ bụ ngwaọrụ ahụ n'onwe ya.

Nke mbu, atọrọ ogwu a na-ahọrọ ka ọ bụrụ ihe efu, ma emesia usoro ịchọrọ iji dozie ya.Ọ bụrụ na onye na-ahọgharị na-agagharị iji belata ọgwụ, ọ dị mkpa iji nyochaa bọtịnụ mmalite, n'ihi na ọ bụrụ na emetụrụ ya aka, mgbe ahụ, nke a nwere ike iduga n'iwe insulin.

Ọ dị mma ịmara na ịtọlite ọgwụ, ịnweghị ike iji ọnụ ọgụgụ nke nkwụsị nke fọdụrụ. Ọzọkwa, ọnụọgụ karịa ọnụọgụ nkeji fọdụrụ na katriel enweghị ike ịtọ.

A na-edozi Mikstard 30 FlexPen n'okpuru anụ ahụ n'otu ụzọ ahụ Mikstard na vials. Agbanyeghị, mgbe nke a gasịrị, anaghị ewepụ mkpụrụ edemede sirinji, mana ọ bụ naanị agịga na-ewepụ. Iji mee nke a, ejiri nnukwu okpu kpuchie ya wee kpuchie ya, wee kpochapụ ya nke ọma.

Yabụ, maka ọgwụ mgbochi ọ bụla, ịkwesịrị iji agịga ọhụrụ. E kwuwerị, mgbe ọnọdụ okpomọkụ gbanwere, insulin enweghị ike iribiga.

Mgbe ị na-ewepụ ma tụfuo agịga, ọ dị oke mkpa na ị ga-akpachara anya maka nchekwa ka ndị na-ahụ maka ahụike ma ọ bụ ndị na-elekọta ndị ọrịa shuga na-agaghị egbu ya na mberede. Ma Spitz-eji nke ejiri eji mee ihe kwesịrị ị tufuo ya n’enweghị agịga.

Ogologo oge ị safeụ ọgwụ Mikstard 30 Flexpen, ọ dị mkpa iji lekọta ya nke ọma, na-edebe iwu nchekwa. E kwuwerị, ọ bụrụ na ngwaọrụ ahụ nwere nrụrụ ma ọ bụ mebie, insulin nwere ike ipupụta na ya.

Ọ dị mma ịmara na FdeksPen enweghị ike ijuju ọzọ. Site n'oge ruo n'oge, a ga-asachapụ oghere nke sirinji pen. Maka ebumnuche a, a na-ehicha ya na owu ajị anụ na-egbu egbu.

Agbanyeghị, emela ngwa ngwa, hichaa ma ọ bụ tinye ya na ngwaọrụ ethanol. E kwuwerị, nke a nwere ike ibute mmebi nke sirinji ahụ.

Doụbiga mmanya ókè, mmekọrịta gị na ọgwụ, ihe na-adịghị mma

N’agbanyeghi n’echiche na echiche nke ịdoụbiga mmanya ókè emepụtabeghị maka insulin, n’ọnọdụ ụfọdụ hypoglycemia nwere ike ịmalite mgbe ọ nwesịrị ọrịa shuga mellitus, mgbe ahụ jiri ntakịrị mbelata na shuga ị kwesịrị ị drinkụ tii dị ụtọ ma ọ bụ rie ngwaahịa nwere carbohydrate. Ya mere, a na-atụ aro ka ndị na-arịa ọrịa shuga na-ebu otu swiiti ma ọ bụ otu shuga na ha mgbe niile.

Na nnukwu hypoglycemia, ọ bụrụ na ọrịa shuga amaghị ihe ọ bụla, a na-eji glucagon onye ọrịa ahụ mee ihe na 0,5-1 mg. N'ime ụlọ ọrụ ọgwụ, a na-enye onye ọrịa ọbara ọbara glucose ọfụma, ọkachasị ma ọ bụrụ na mmadụ anaghị emeghachi omume na glucagon n'ime nkeji 10-15. Iji gbochie nlọghachi, onye ọrịa nwetaghachiri maara kwesịrị itinye carbohydrates n'ime.

Drugsfọdụ ọgwụ na-emetụta metabolism. Ya mere, mgbe ị na-ekpebi ọgwụ insulin, a ga-elebara nke a anya.

Yabụ, mmetụta insulin na-emetụta:

Mmanya na-egbu egbu, ọgwụ hypoglycemic, salicylates, ACE inhibitors, MAO na-abụghị ndị na - ahọrọ B - na - belata mkpa nke homonụ.
B-igbochi - ihe nkpuchi nke hypoglycemia.
Danazole, thiazides, homonụ na-eto, glucocorticoids, b-sympathomimetics na homonụ thyroid - na-abawanye mkpa maka homonụ.
Mmanya na - egbu egbu - na - agbatị ma ọ bụ na - eme ka ihe insulin kwadebe.
Lancreotide ma ọ bụ Octreotide - nwere ike ịbawanye ma wedata mmetụta insulin.

Ọtụtụ mgbe, nsonaazụ n'akụkụ mgbe itinye Mikstard na-ebilite n'ihe banyere usoro ị doụ ọgwụ na-ezighi ezi, nke na-eduga n'ọbara hypoglycemia na malfunctions. Ọdịda shuga dị larịị na-ebute oke nju, nke jikọtara ya na nkwarụ, enweghị mmụọ na ịrụ ọrụ ụbụrụ.

Ọrịa ndị ọzọ na-adịghị ahụkebe gụnyere ọzịza, retinopathy, neuropathy akụkụ, lipodystrophy na rashes (urticaria, ihe nhiwe).

Ọrịa site na akpụkpọ anụ yana anụ ahụ dị n'okpuru ala nwekwara ike ime, mmeghachi omume mpaghara na-etolite na saịtị ịgba ama.

Ya mere lipodystrophy na ọrịa shuga na-apụta naanị ma ọ bụrụ na onye ọrịa agbanweghị ebe ịgba ọgwụ mgbochi. Mmeghachi omume mpaghara gụnyere hematomas, ọbara ọbara, ọzịza, ọzịza na itching nke na - apụta na ntụtụ. Agbanyeghị, nyocha nke ndị ọrịa mamịrị na-ekwu na ihe ịtụnanya ndị a na-aga n'ihu na usoro ọgwụgwọ.

Ọ dị mma ịmara na site na ngwangwa ọ bụla na njikwa glycemic, onye ọrịa ahụ nwere ike ịmalite ịrịa ọrịa neuropathy na-enweghị ike. Nsonaazụ ndị a na-adịghị ahụkebe gụnyere ụtụ anaphylactic na mgbakasị ahụ na-eme na mbido ọgwụgwọ. Agbanyeghị, nyocha nke ndị ọrịa na ndị dọkịta na-ekwu na ọnọdụ ndị a adịghị adịte aka ma na-adịru nwa oge.

Ihe ịrịba ama nke hypersensitivity nwere ike jikọtara ya na malfunctions na usoro nri, ọnya anụ ahụ, mkpụmkpụ ume, itching, palpitations, angioedema, ọbara mgbali elu na nkụ. Ọ bụrụ na ọrịa ndị dị otú ahụ apụta, ị kwesịrị ịkpọtụrụ dọkịta ozugbo, n'ihi na ọgwụgwọ na-enweghị isi nwere ike ibute ọnwụ.

Ọnụ ego ọgwụ Mikstard 30 NM bụ ihe dị ka 660 rubles. Ọnụahịa Mikstard Flexpen dị iche. Yabụ, pensụl pensụl na-efu site na 351 rubles, na katrized si 1735 rubles.

Nnukwu analogues nke insulin biphasic bụ: Bioinsulin, Humodar, Gansulin na Insuman. Ekwesịrị ịchekwa Mikstard n'ebe gbara ọchịchịrị karịa afọ 2.5.

Vidio dị n’isiokwu a na-egosi usoro eji edozi insulin.

Nhazi ATX: A10AD01 insulin (mmadụ)
Mnn ma obu aha ndi otu: Insulin
Otu ọgwụ:
Onye nrụpụta: Amaghị ama
Onye nwe ikike: Amaghi ama
Obodo: Amaghi ama

Ntụziaka ọgwụ

ogwu ogwu

Mikstard® 30 NM

Aha ahia

International Nonproprietary Aha

Mpempe usoro onunu ogwu

Nkwụsịtụ maka nchịkwa subcutaneous, 100 IU / ml

Ngwakọta

1 ml nke ọgwụ nwere

ike - mkpụrụ ndụ ihe nketa insulin mmadụ 3.50 mg (100 IU) 1,

1 Ọgwụ ahụ nwere insulin mmadụ na-eme 30% na 70% isofan-insulin

Nkọwa

Ndị na-ere ọgwụ

Insulin na analogues, ndi ozo n’eji ya na insulin na-aru oru.

Koodu PBX A10AD01

Ngwongwo ogwu

Mlọ ọgwụ

Oke ịta (C_max) a na - enweta insulin plasma n'ime 1.5 - 2.5 awa mgbe nchịkwa subcutaneous gasịrị.

O nweghị ihe akpọrọ ihe na-egbochi protein amasara ahụ, ewezuga ọgwụ mgbochi insulin (ọ bụrụ na ọ dị).

Ndụ ọkara (T½) kpebisiri ike ịnwe nzere site na anụ ahụ dị n'okpuru ala. Ya mere T_½ kama nke ahụ, ọ bụ ihe a na-amị amị, ọ bụghịkwa ihe nke iwepu insulin na plasma (T_½ insulin si n'ọbara bu nkeji ole na ole). Mmụta emere egosi na T_½ bụ ihe dịka awa 5-10.

Mlọ ọgwụ

Ihe ngosi maka ojiji

- ọgwụgwọ nke ọrịa shuga

Usoro onunu ogwu na nhazi

A na-enyekarị insulin ọgwụ jikọtara ọnụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị ma ọ bụrụ na achọrọ ngwakọta nke nsonaazụ ngwa ngwa na ogologo oge.

A na-enye ọgwụ ahụ nkeji iri atọ tupu nri ma ọ bụ nri nwere carbohydrates.

Maka nhazi dị n'okpuru ala. N'ọnọdụ ọ bụla, ekwesịrị iji ọgwụ insulin kwụsịtụrụ. Mikstard ® 30 NM a na-enyekarị subcutaneously na mpaghara nke mgbidi ihu. Ọ bụrụ na nke a dabara adaba, mgbe ahụ injections nwekwara ike ịme n’apata ụkwụ, mpaghara gluteal ma ọ bụ mpaghara mpaghara akwara dị n’ubu (subcutaneously). Site na ntinye ọgwụ a na mpaghara mpaghara mgbidi afọ, a na-enweta mmịpụ ngwa ngwa karịa iwebata ya na mpaghara ndị ọzọ. Perrụpụta ntụtụ n’akpụkpọ ahụ na-ebelata ohere ịbanye n’olu. Okwesiri igbanwe ebe igba ogwu n’etiti mpaghara anatomical iji belata nsogbu nke lipodystrophy.

Ntụziaka maka iji Mikstard® 30 NM, nke a ga-enyerịrị onye ọrịa ahụ.

Ejila Mikstard® 30 NM:

Na nfuli insulin.
Ọ bụrụ na enwere ihe nfụkasị (hypersensitivity) na insulin mmadụ ma ọ bụ na ihe ọ bụla mejupụtara Mikstard® 30 NM.
Ọ bụrụ hypoglycemia amalite (shuga dị ala).
Ọ bụrụ na echeghị insulin n'ụzọ ziri ezi, ma ọ bụ kpụọ ya oyi
Ọ bụrụ na okpu nchebe na-efu ma ọ bụ tọghe. Kalama ọ bụla nwere okpu plastik na-echebe ya.
Ọ bụrụ na insulin apụtaghị na-acha ọcha na urukpuru mgbe agwakọchara.

Tupu iji Mikstard® 30 Nm:

Lelee akara ahụ iji jide n'aka na ị na-eji ụdị insulin dị mma.
Wepu okpu nchebe.

Etu ị ga-esi jiri ọgwụ ọjọọ Mikstard® 30 NM

Dị njikere ijiri sirinji insulin na-etinyere ọ̀tụ̀tụ̀ iji tụọ ọ̀tụ̀tụ̀ ahụ na nkeji ihe.
Dọrọ ikuku banye ntụtụ na ọnụego insulin chọrọ chọrọ.
Ngwa ngwa tupu ị theụ ọgwụ ahụ, tụgharịa vial ya n'etiti ọbụ aka gị ruo mgbe insulin na-acha ọcha ma nwee urukpuru. A na-emeghachite mbugharị ọzọ ma ọ bụrụ na ọgwụ nwere ọnụ ụlọ ahụ.
Tinye insulin n'okpuru anụahụ.
Jide agịga n'okpuru anụ ahụ maka ọ dịkarịa ala 6 sekọnd iji jide n'aka na a na-edozi ọgwụ insulin nke ọma.

Mmeghachi omume na-adịghị mma nke a hụrụ na ndị ọrịa n'oge ọgwụgwọ na Mikstard were 30 NM bụ nke dabere na ntanetị nke ukwuu ma bụrụ n'ihi usoro ọgwụ insulin.

Aha: Mikstard 30 NM Penfill (Mixtard 30 HM Penfill)

Leasedị ntọhapụ, ihe mejupụtara na mkpọ

Nkwụsịtụ maka nchịkwa sc nke 1 ml ngwakọta nke insulin mmadụ na-agakọ na nkwụsị nke insulin 100 IU insulin mmadụ na-egbochi 30% insulin insulin nke 70%.

Linlọ ọgwụ na ọgwụ ọgwụ: insulin nke ọkara oge.

Mikstard 30 NM Penfill bụ nkwusioru insulin nke biosynthetic mmadụ isofan insulin nke ime mmụọ ihe. Mmalite nke ọrụ bụ mgbe nkeji iri atọ gachara nchịkwa subcutaneous. Mmetụta kachasị na-etolite n'etiti awa 2 na awa 8. Ogologo oge nke ime ihe dị ka awa 24. profaịlụ nke insulin na-agbago: ọ dabere na ogo ngwaahịa ahụ ma gosipụta njirimara mmadụ.

Ntinye insulin na, n'ihi ya, mmalite nke mmetụta hypoglycemic, na-adabere na ntinye ahụ (afọ, apata ụkwụ, ụkwụ), olu ntụtụ, ịta insulin na ụfọdụ ihe ndị ọzọ. N'ime ọbara, T1 / 2 nke insulin bụ nkeji ole na ole.

Ya mere, profaịlụ nke insulin na-adabere dabere na ọnụego ya. Ọtụtụ ihe na-emetụta usoro a, n'ihi nke ọdịiche dị iche iche nke ndị mmadụ ga-ekwe omume. Mgbe ị na-agbanwe site na ntinye insulin nke 40 PIECES / ml ka ọ bụrụ 100 PIECES / ml, obere mgbanwe na ntinye insulin n'ihi oke olu na-akwụghachi ụgwọ ya site na itinye uche ya.

Ọ bụ ihe amamihe dị na ya ị useụ insulins biphasic nwere ọrịa shuga kwụsiri ike.

Usoro Njikere Cartridge

Penfill na Okwu Mmeghe

Tupu itinye Penfill katriki na pen sirinji, a ghaghi ịma jijiji ma gbadaa. Ekwesịrị ịme mmegharị ahụ n'ụzọ ga-eme ka bọl iko dị na katriiki si n'otu nsọtụ gaa na nke ọzọ. Ekwesịrị imeghari mgbatị a ugboro iri - ugboro - rue mgbe mmiri mmiri ahụ ga - acha ọcha ma dị otu.

Ọ bụrụ na etinyelarrị ihe ndị dị na Penfill n'ime pen sirinji, gụgharịa usoro agwakọta tupu ntụtụ ọ bụla. Mgbe ịgba ntụtụ ahụ, agịga ahụ kwesịrị ịnọ n'okpuru akpụkpọ ahụ opekata mpe isii. A ga-agbanye bọtịnụ mkpịsị ọpịpịa ruo mgbe agịpụsịrị agịga ahụ n'okpuru akpụkpọ ahụ. Mgbe ogwu ogbugba nke ọ bụla, a ga-ewepụ agịga ozugbo. Penfill bụ makaonwe ya. Enwere ike iji kadi Penfill mee ihe na NovoPen 3, mkpịsị Innovo ma ọ bụ buru gị ruo otu ọnwa. Mgbe etinyere katriji n’ime mkpịsị mkpụrụ vaịn NovoPen 3, a ga-ahụrịrị akara ngosi na agba site na windo nke onye na-ejide ya.

Mmetụta akụkụ ndị metụtara ya na nsonaazụ metabolism: ọnọdụ hypoglycemic (pallor, ịba ụba ịba ụba, palpitations, nsogbu ihi ụra, ịma jijiji).

Mmeghachi omume nfụkasị: ọ bụghị oge - ọnya anụ ahụ, ọ na - adịkarịghị - angioedema. Mmeghachi omume mpaghara: ọ bụghị oge - hyperemia na itching na ebe ngbanye ngwaahịa ahụ, yana iji ogologo oge ọ bụghị - lipodystrophy na saịtị ahụ.

Ime na lactation

N’oge ime na n’azụ, mkpa onye insulin na-agbanwe ga-agbanwe, nke a ga-elebara anya iji wee nwee ike ịchịkwa usoro metabolic zuru oke. Insulin anaghị agafe ihe mgbochi placental. Mgbe ị na-eji ngwaahịa ahụ Mikstard 30 NM Penfill n'oge a na-enye ya ara, ọ dịghị ihe ize ndụ dị na nwa ahụ.

Ndị ọrịa na-enweta ihe karịrị 100 IU nke insulin kwa ụbọchị kwesịrị ịga ụlọ ọgwụ mgbe ha na-agbanwe ngwaahịa ahụ. Ọkpụkpụ site na ụdị insulin na nke ọzọ ga-ebufe n'okpuru ịchịkwa ọkwa glucose ọbara. N'okpuru mmetụta nke insulin, nnabata nke mmanya na-ebelata.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Mgbe emechara onye ọrịa ahụ insulin biotinnthetic mmadụ, ikike ịkwọ ụgbọ ala na itinye aka na ọrụ ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor nwere ike ịdalata nwa oge.

Mgbaàmà: mgbaàmà mbụ nke hypoglycemia - mmụba na mberede na ịatingụ mmiri, palpitations, ịma jijiji, agụụ, oke iwe, paresthesia n'ọnụ, pallor, isi ọwụwa, ọgba aghara ụra. Na akwa ikpe nke nnyefere - coma.

Ọgwụgwọ: onye ọrịa ahụ nwere ike iwepụ hypoglycemia dị nwayọ site na ị sugarụ shuga ma ọ bụ nri nwere shuga. N'ọnọdụ siri ike, subcutaneous ma ọ bụ intramuscularly na-achịkwa 1 mg nke glucagon. Ọ bụrụ na ọ dị mkpa, a na-aga n'ihu usoro ọgwụgwọ na ntinye nke usoro dextrose ndọpụ.

A na - eme ka mmetụta hypoglycemic nke insulin na MAO inhibitors, beta-blockers, sulfonamides, steroid anabolic, tetracyclines, clofibrate, cyclophosphamide, fenfluramine, na ngwaahịa nwere ethanol.

Ihe mgbochi oral, glucocorticoids, homonụ thyroid, thiazide diuretics, heparin, ngwaahịa lithium, ọgwụ tricyclic antidepressants na-ebelata mmetụta hypoglycemic nke insulin. N'okpuru mmetụta nke reserpine na salicylates, ma ime ka insulin na-ebelata ma na-akwalite ọrụ insulin ga-ekwe omume.

Ethanol, ọgwụ dị iche iche nwere ike belata ọrụ ndu insulin.

Ọnọdụ nchekwa na oge

Ekwesịrị ịchekwa cartilge na ngwugwu ebe a na-echebe ya site na ìhè anyanwụ na okpomọkụ nke 2 Celsius ruo 8 Celsius, emela.

A naghị atụ aro kapịa Penfill a na-eji na friji.

Ntị!
Tupu itinye ọgwụ ahụ n'ọrụ “Mixtard 30 NM Penfill” Ọ dị mkpa ịga hụ dọkịta.
A na-enye ntụziaka ahụ naanị ka ị mara onwe gị na " Mikstard 30 NM Penfill (Mixtard 30 HM Penfill)».

Nkwadebe: MIXTARD ® 30 Nm PENFILL ® (MIXTARD ® 30 HM PENFILL ®)

Ihe na-arụ ọrụ: inpaine insulin na-abanyerodne
Koodu ATX: A10AD01
KFG: Ogologo Ogologo Nnyocha Ọgwụ mmadụ
Koodu ICD-10 (ihe ngosi): E10, E11
Reg. nọmba: P Nke 014312 / 02-2003
Ofbọchị idebanye aha: 06.16.03
Ndi nwe reg. doc.: NOVO NORDISK (Denmark)

OSBỌCH D DOSAGE, NJIKWU NA AKPACKTA

3 ml - katrized (5) maka mkpụrụ osisi svoe NovoPen - ngwungwu sel (1) - ngwugwu nke kaadiboodu.

EGO NA-EGO NA-EGO EGO.
Nkọwa ọgwụ nke onye nrụpụtara masịrị na 2004

AKPỌ PHARMACOLOGICAL

Mikstard 30 NM Penfill bụ nkwusioru insulin nke biosynthetic mmadụ isofan insulin nke ime mmụọ ihe. Mmalite nke ọrụ bụ nkeji iri atọ mgbe nchịkwa subcutaneous gasịrị. Mmetụta kachasị na-etolite n'etiti awa 2 na awa 8. Ogologo ihe ọ bụla bụ ruo awa 24.

Ihe omuma nke insulin emechara bu ihe oma: o dabere na ncha ogwu a ma gosiputa udiri onye.

PHARMACOKINETICS

Ntinye insulin na, n'ihi ya, mmalite nke mmetụta hypoglycemic, na-adabere na ntinye ahụ (afọ, apata ụkwụ, ụkwụ), olu ntụtụ, ịta insulin na ụfọdụ ihe ndị ọzọ.

N’ime ọbara T_1/2 insulin bu nkeji ole na ole. Ya mere, profaịlụ nke insulin na-adabere dabere na ọnụego ya. Ọtụtụ ihe na-emetụta usoro a, n'ihi nke ọdịiche dị iche iche nke ndị mmadụ ga-ekwe omume.

Mgbe ị na-agbanwe site na ntinye insulin nke 40 PIECES / ml ka ọ bụrụ 100 PIECES / ml, obere mgbanwe na ntinye insulin n'ihi oke olu na-akwụghachi ụgwọ ya site na itinye uche ya.

NWA OMA

- insulin na-arịa ọrịa shuga mellitus (ụdị nke m),

- ọrịa mellitus na-arịa insulin na-abụghị insulin (ụdị II): ọkwa nke iguzogide ndị nnọchianya hypoglycemic nke ọnụ, nguzogide akụkụ nke ọgwụ ndị a (n'oge ọgwụgwọ njikọta), ọrịa intercurrent, arụmọrụ, ịtụrụ ime.

OSBOSR D OSBỌCH.

Ọ bụ ihe amamihe dị na ya ị useụ insulins biphasic nwere ọrịa shuga kwụsiri ike. Site na mellitus na-arịa insulin na-abụghị insulin, dịka iwu, jiri Mikstard 30 NM Penfill.

Ọgwụ nke ọgwụ Mikstard 30 NM Penfill ka dọkịta kpebiri n’otu n’otu n’otu n’otu. A na-achịkwa ọgwụ ahụ n'okpuru ala. Mgbe ịgba ntụtụ ahụ, agịga kwesịrị ịdị n’okpuru anụ ahụ maka sekọnd isii, nke na-ahụ na ị doseụ ọgwụ zuru oke.

Mgbe ị na-ebufe onye ọrịa site na ezì dị ọcha ma ọ bụ insulin nke mmadụ na Mikstard 30 NM Penfill, ị doseụ ọgwụ ahụ ka dị otu.

Mgbe ị na-ebufe onye ọrịa site na anụ ehi ma ọ bụ insulin gwakọtara ya na Mikstard 30 NM Penfill, ọgwụ insulin na-agbadakarị 10%, belụsọ mgbe usoro izizi erughị 0.6 U / n'arọ nke oke ahụ.

N 'ụbọchị ị gafere 0.6 IEBIER kg / n'arọ nke ịdị arọ anụ ahụ, a ga-enyocha insulin dị ka ọgwụ mgbochi abụọ 2 n'ebe dị iche iche.

Iwu iwu maka iji ihe eji ede ihe nke Penfill na nchịkwa ọgwụ

Tupu ijide ya, gbaa mbọ hụ na enweghị arụrụala prọfesọ Penfill. Achọghị Penfill ma ọ bụrụ na enwere mbibi ọ bụla a na-ahụ anya ma ọ bụ ọ bụrụ na obosara nke akụkụ a na-ahụ anya nke pistin roba karịrị obosara nke warara dị ọcha. Tupu itinye Penfill katriiki na pen sirinji, ekwesiri ịma jijiji ma gbadaa. Ekwesịrị ịmegharị ka bọọlụ iko dị n'ime katriiki ahụ si n'otu nsọtụ ruo na nsọtụ nke ọzọ. Ekwesịrị imeghari mgbatị a ugboro iri - ugboro - rue mgbe mmiri mmiri ahụ ga - acha ọcha ma dị otu. Ọ bụrụ na etinyelarrị ihe ndị dị na Penfill n'ime pen sirinji, gụgharịa usoro agwakọta tupu ntụtụ ọ bụla. Mgbe a gbasịrị ya, agịga kwesịrị ịdị n’okpuru anụ ahụ ma ọ dịkarịa ala 6 sekọnd. A ga-agbanye bọtịnụ mkpịsị ọpịpịa ruo mgbe agịpụsịrị agịga ahụ n'okpuru akpụkpọ ahụ. Mgbe ogwu ogbugba nke ọ bụla, a ga-ewepụ agịga ozugbo.

Penfill bụ makaonwe ya.

Enwere ike iji kadi Penfill mee ihe na NovoPen 3, mkpịsị Innovo ma ọ bụ buru gị ruo otu ọnwa.

Mgbe etinyere katriji n’ime mkpịsị mkpụrụ vaịn NovoPen 3, ibe kwesịrị acha na windo nke onye na-ejide ya.

NWAANYI EGO

Mmetụta ndị metụtara ya na nsonaazụ metabolism: Ọnọdụ hypoglycemic (pallor, sweating ụba, palpitations, nsogbu ihi ụra, ịma jijiji).

Mmeghachi omume nfụkasị ahụ: adịkarịghị - ọnya anụ ahụ, ọ na - adịkarị obere - angioedema.

Mmeghachi omume mpaghara: adịkarịghị - hyperemia na itching na ebe ngbanye ọgwụ, ebe iji ogologo oge adịkarịghị - lipodystrophy na saịtị ahụ.

NSOGBU NIILE

NKWUP ANDR AND NA AKCTTA

N’oge ime na n’azụ, mkpa onye insulin na-agbanwe ga-agbanwe, nke ekwesiri iburu n’uche iji nwee ike ị nweta ọgwụ metabolic zuru oke.

Insulin anaghị agafe ihe mgbochi placental.

Mgbe ị na-eji ọgwụ Mikstard 30 NM Penfill n'oge a na-enye nwa ara, ọ dịghị ihe ize ndụ ọ bụla maka nwatakịrị ahụ.

AKWSTRUCTIONKWỌ NDEC NA-EGO

Ndị ọrịa na-enweta ihe karịrị 100 IU nke insulin kwa ụbọchị kwesịrị ịga ụlọ ọgwụ mgbe ha na-agbanwe ọgwụ.

Ọkpụkpụ site na ụdị insulin na nke ọzọ ga-ebufe n'okpuru ịchịkwa ọkwa glucose ọbara.

N'okpuru mmetụta nke insulin, nnabata nke mmanya na-ebelata.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

OGBONA

Ọrịa mgbaàmà mbụ nke hypoglycemia - mmụba na mberede ọsụsọ, palpitations, ịma jijiji, agụụ, nhụjuanya, paresthesia n'ọnụ, pallor, isi ọwụwa, ọgba aghara ụra. Na akwa ikpe nke nnyefere - coma.

Ọgwụgwọ: onye ọrịa ahụ nwere ike iwepụ hypoglycemia dị nro site na-eri shuga ma ọ bụ nri ndị nwere shuga. N'ọnọdụ siri ike, subcutaneous ma ọ bụ intramuscularly na-achịkwa 1 mg nke glucagon. Ọ bụrụ na ọ dị mkpa, a na-aga n'ihu usoro ọgwụgwọ ahụ na ntinye nke usoro dextrose siri ike.

INI IGBU EGO

A na - eme ka mmetụta hypoglycemic dị na insulin site n'aka MAO inhibitors, beta-blockers, sulfonamides, steroid anabolic, tetracyclines, clofibrate, cyclophosphamide, fenfluramine, na nkwadebe nwere ethanol.

Ihe mgbochi oral, glucocorticoids, homonụ thyroid, thiazide diuretics, heparin, nkwadebe lithium, ọgwụ tricyclic antidepressants na-ebelata mmetụta hypoglycemic nke insulin.

N'okpuru mmetụta nke reserpine na salicylates, ma ime ka insulin na-ebelata ma na-akwalite ọrụ insulin ga-ekwe omume.

Ethanol, ọgwụ dị iche iche nwere ike belata ọrụ ndu insulin.

NJIKWU EGO PHARMACY

Ogwu gi bu ogwu.

Usoro na ọnọdụ

Ekwesịrị ịchekwa cartilge na ngwugwu, ebe a na-echebe ya site na ìhè anyanwụ na okpomọkụ nke 2 Celsius ruo 8 Celsius. A naghị atụ aro kapịnye Penfill a na-eji na friji.

Mazovetsky A.G., Velikov V.K. Ọrịa shuga mellitus, Ọgwụ -, 1987. - 288 p.
Nchọpụta ụlọ nyocha Tsonchev nke ọrịa rheumatic / Tsonchev, V ọzọ na. - M.: Sofia, 1989 .-- 292 p.
Daeidenkoea E.F., Liberman I.S. Jenetik nke ọrịa shuga. Leningrad, bipụtara ụlọ "Medicine", 1988, 159 pp.

Ka m kọwaa onwe m. Aha m bụ Elena. Anọwo m na-arụ ọrụ dị ka ọkà mmụta endocrinologist ruo ihe karịrị afọ 10. Ekwenyere m na abụ m ọkachamara n'ọhịa m ugbu a, m chọrọ inyere ndị ọbịa niile nọ na saịtị ahụ aka idozi ihe dị mgbagwoju anya ọ bụghị ọrụ. A na-achịkọta ihe niile dị na saịtị ahụ ma jiri nlezianya hazie iji kọọ ozi niile dị mkpa. Tupu itinye ihe akọwara na weebụsaịtị, ndụmọdụ mmetụtara na ndị ọkachamara dị mkpa mgbe niile.

Ntuziaka maka iji ọgwụ ahụ

Tupu ịmalite insulin ọgwụ, ọtụtụ iwu kwesịrị ịmụ:

Anaghị anabata nkwụsị.
A na-eme irighiri mmiri dị n'okpuru mgbidi nke apata ụkwụ, apata ụkwụ, na mgbe ụfọdụ, na olu dị iche iche n'ubu ma ọ bụ n'ọkpụkpụ ụkwụ.
Tupu okwu mmeghe, ọ bụ ihe amamihe dị na ya igbu oge ikpuchi akpụkpọ ahụ, nke ga-ebelata ohere nke ngwakọta na-abanye n’uru ahụ.
Should ga-amarakwa na site na iji ọgwụ s / c nke insulin banye na mgbidi nke afọ, ịmịkọrọ ya na-eme ngwa ngwa karịa iwebata ọgwụ na mpaghara ndị ọzọ.
Iji gbochie mmepe nke lipodystrophy, a ghaghị ịgbanwe saịtị ntụtụ mgbe niile.

Ọ dị mma ịmara na karama ahụ nwere okpu na-echebe plastic na-ewepụ tupu ngwa insulin.

Agbanyeghị, ọ ga-ebu ụzọ lelee otu esi ejikọ mkpuchi ahụ na ite ahụ, ọ bụrụ na ọ na-efu efu, mgbe ahụ, a ga-akpọghachi ọgwụ ahụ n'ụlọ ahịa ọgwụ.

Mikstard 30 Flexpen: ntuziaka maka ojiji

Nyocha nke ndị dọkịta na ọtụtụ ndị ọrịa mamịrị na-agbadata n'eziokwu na ọ kachasị adaba iji Mixtard 30 FlexPen.

Nke a bụ mkpịsị insulin na-eji ọgwụ ọnụọgụ na-ahọrọ, nke ị nwere ike ịhapụta usoro onodu ogwu site na nkeji 1 ruo 60 na mmụba nke otu nkeji.

Mgbe nke ahụ mechara, ịkwesịrị ịme usoro ndị a:

A na-agwọ akpụkpọ anụ roba na-egbu egbu.
Ewepu akara nchekwa na agịga.
Ọkpụkpụ na-emerụ na Flexpen.
A na-ewepụ ikuku n'ime kadi.

Nke mbu, atọrọ ogwu a na-ahọrọ ka ọ bụrụ ihe efu, ma emesia usoro ịchọrọ iji dozie ya. Ọ bụrụ na onye na-ahọgharị na-agagharị iji belata ọgwụ, ọ dị mkpa iji nyochaa bọtịnụ mmalite, n'ihi na ọ bụrụ na emetụrụ ya aka, mgbe ahụ, nke a nwere ike iduga n'iwe insulin.

Yabụ, maka ọgwụ mgbochi ọ bụla, ịkwesịrị iji agịga ọhụrụ. E kwuwerị, mgbe ọnọdụ okpomọkụ gbanwere, insulin enweghị ike iribiga.

Ọ dị mma ịmara na FdeksPen enweghị ike ijuju ọzọ. Site n'oge ruo n'oge, a ga-asachapụ oghere nke sirinji pen.Maka ebumnuche a, a na-ehicha ya na owu ajị anụ na-egbu egbu.

Agbanyeghị, emela ngwa ngwa, hichaa ma ọ bụ tinye ya na ngwaọrụ ethanol. E kwuwerị, nke a nwere ike ibute mmebi nke sirinji ahụ.

Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ

Dị ka ị maara, ọtụtụ ọgwụ na-emetụta metabolism metabolism.

Ọgwụ nwere ike belata chọrọ insulin

Ndị na-ahụ maka hypoglycemic oral (PSS), monoamine oxidase inhibitors (MAOs), ndị na-abụghị ndị na - eme nhọrọ, ACE inhibitors (ACE), salicylates, anabolic steroids na sulfonamides.

Ọgwụ nwere ike ịbawanye ụba insulin

Ihe mgbochi oral, thiazides, glucocorticoids, homonụ thyroid, sympathomimetics, homonụ na-eto eto na danazole.

ndị na-egbochi adrenergic nwere ike kpuchie mgbaàmà hypoglycemia ma belata mgbake mgbe hypoglycemia.

Octreotide / lanreotide nwere ike belata ma bulie mkpa insulin.

Mmanya na-egbu egbu nwere ike iwelie ma ọ bụ ibelata mmetụta hypoglycemic nke insulin.

Njirimara ngwa

Ọgwụ ezughị ezu ma ọ bụ ịkwụsị ịgwọ ọrịa (ọkachasị ụdị nke ịrịa ọrịa shuga) nwere ike ibute hyperglycemia na ketoacidosis na-arịa ọrịa shuga. Ọtụtụ mgbe, mgbaàmà mbụ nke hyperglycemia na-amalite nwayọọ nwayọọ karịa ọtụtụ awa ma ọ bụ ụbọchị. Ha gụnyere akpịrị ịkpọ nkụ, ure ugboro ugboro, ọgbụgbọ, vomiting, ụra, akpịrị na akpọnwụ akpịrị, akpịrị ịkpọ nkụ, agụụ, na isi nke acetone n'ikuku.

Diabetesdị ọrịa shuga m, hyperglycemia, nke a na-agwọghị, na-eduga na ketoacidosis mamịrị, nke nwere ike ịnwụ.

Hypoglycemia nwere ike ịpụta ma ọ bụrụ na insulin n ’oke dị n’ mkpa maka insulin. N'ọnọdụ hypoglycemia ma ọ bụ ọ bụrụ na enyo hypoglycemia, emela ọgwụ ahụ.

Iri nri ma ọ bụ imega ahụ́ ọ bụla ị na-atụghị anya ya nwere ike iduga hypoglycemia.

Ndị ọrịa emeela ka ọ dịkwuo mma ịchịkwa ọkwa glucose ọbara n’ihi ọgwụgwọ insulin na-agba ike nwere ike ịchọpụta mgbanwe na mgbaàmà ha na-emebu, ihe na-ebute hypoglycemia, nke e kwesịrị ịdọ aka na ntị tupu oge eruo.

Ihe ịrịba ama nke ịdọ aka na ntị nwere ike apụ n'anya na ndị ọrịa nwere ọrịa shuga ogologo oge.

Ihe mgbochi, ọkachasị ọrịa na ahụ ọkụ, na-abawanye mkpa ịchọrọ insulin. Ọrịa conisitant nke akụrụ, imeju, gland adrenal, pituitary gland, thyroid gland nwere ike ime ka mkpa mgbanwe mgbanwe onunu insulin. Mgbe a na-ebugharị onye ọrịa na ụdị insulin ọzọ, mgbaàmà nke hypoglycemia nwere ike gbanwee ma ọ bụ kwuo okwu.

Ntugharị onye ọrịa na ụdị ọzọ ma ọ bụ ụdị insulin na-adị n'okpuru nlekọta ahụike siri ike. Mgbanwe na ịta, ụdị (onye nrụpụta), ụdị, insulin (mmadụ ma ọ bụ ihe ana insulin) na / ma ọ bụ usoro mmepụta nwere ike ime ka mmegharị insulin dị mma. Ndị ọrịa ebugharị na Mikstard ® 30 NM nwere ụdị insulin ọzọ nwere ike ịchọ mmụba nke ọnụ ọgụgụ ịgba ọgwụ kwa ụbọchị ma ọ bụ mgbanwe mgbanwe na usoro iji tụnyere insulin ha na-ejikarị. Mkpa nke ịhọrọ nhọrọ nwere ike ibilite ma n'oge nchịkwa mbụ nke ọgwụ ọhụrụ, yana n'ime izu ole na ole ma ọ bụ ọnwa mbụ nke iji ya.

Mgbe ị na-eji ọgwụ insulin ọ bụla, mmeghachi omume nwere ike ime na ebe injection, nke nwere ike ịgụnye ihe mgbu, ọbara ọbara, itching, hives, brusing, ọnya na ọnya.

Ekwesighi iji nruchi insulin na nfuli insulin maka nchịkwa insulin nke nwere ogologo oge.

Njikọ nke thiazolidinediones na ngwaahịa insulin

Mgbe ejiri thiazolidinediones na insulin, a kọpụtawo ikpe metụtara obi nkụchi, ọkachasị ndị ọrịa nwere ihe ọghọm maka nkụchi obi. Ekwesịrị ịtụle nke a mgbe ị na-ede akwụkwọ ọgwụgwọ yana ngwakọta nke thiazolidinediones na insulin. Site na iji ọgwụ ndị a jikọtara ọnụ, ndị ọrịa kwesịrị ịnọ n'okpuru nlekọta nke dọkịta maka mmepe nke ihe ịrịba ama na mgbaàmà nke ọrịa obi ọrịa, oke ibu na ihe omume edema. N'ọnọdụ ọghọm ọ bụla na arụ ọrụ obi, a ga-akwụsị ịgwọ thiazolidinediones.

Ndị okenye ọrịa (> 65 afọ).

Enwere ike iji ọgwụ Mikstard® 30 NM mee ihe na ndị ọrịa agadi.

N'ime ndị ọrịa agadi, ekwesịrị ime ka nlekọta glucose sie ike ma dozie insulin n'otu n'otu.

Mgbaaka na imeju imeju.

Renal na ịba ọcha n'anya nwere ike belata insulin. N'ime ndị ọrịa nwere akụrụ na hepatic enweghi ike, ekwesịrị ime ka nlebara glucose sie ike ma dozie insulin n'otu n'otu.

Jiri n’oge ime ma ọ bụ n’ịra .

N'ihi insulin anaghị agafe ihe mgbochi placental, enweghị njedebe maka ịgwọ ọrịa shuga na insulin n'oge ime.

Mkpa insulin na-agbadata n'oge ọnwa mbụ nke afọ ime wee mụbaa nke ukwuu na nke abụọ

Mgbe amuchara nwa, mkpa ịba insulin na-alaghachi ngwa ngwa.

Enweghịkwa mgbochi ọ bụla na ịgwọ ọrịa shuga na insulin n'oge a na-enye nwa ara, ebe ọ bụ na ọgwụgwọ nke nne anaghị etinye nwatakịrị ahụ ihe ọ bụla. Agbanyeghị, ọ nwere ike ịdị mkpa ịhazigharị ọnụọgụ na / ma ọ bụ nri nne maka nne.

Nkuzi nke anumanu gbasara omumu banyere umu mmadu

ekpugheghi ihe ojoo obula banyere nri uto.

Ikike iji metụta ọnụego mmeghachi omume mgbe ị na-anya ụgbọala ma ọ bụ usoro ndị ọzọ.

Nzaghachi onye ọrịa na ike itinye uche ya nwere ike ịmetụta hypoglycemia.

Nke a nwere ike ibute ihe egwu n'ihe banyere ọnọdụ ebe ikike a dị ezigbo mkpa (dịka ọmụmaatụ, mgbe ị na-anya ụgbọ ala ma ọ bụ igwe).

A dụrụ ndị ọrịa ọdụ ka ha mee ihe iji gbochie hypoglycemia tupu ha akwọ ụgbọala. Nke a dị ezigbo mkpa maka ndị ọrịa daa mba ma ọ bụ ndị na - anọghị na mgbaàmà nke hypoglycemia ma ọ bụ ngosipụta nke hypoglycemia ugboro ugboro. N'ọnọdụ ndị dị otú ahụ, o kwesịrị ịdị mkpa ịnya ịnya ụgbọ ala.

Ngwakọta na ụdị ntọhapụ

1 ml nke nkwusioru nke injection nwere insulin biosynthetic mmadụ 100 IU (insulin insulin 30% na isofan-insulin nkwusioru 70%), na 3 ml Penfill cartridges maka iji ya na NovoFen 3 pen insuline na pensụl NovoFine yana na cartilages 1.5 ml Penfill. maka iji na NovoPen ma ọ bụ NovoPen II pensụl pensụl, na pọọlụ pịrịpọ 5 pcs. ma ọ bụ karama dị milimita iri.

Mmeghachi omume ọjọọ

Mmetụta dị n’akụkụ ọgwụgwọ bụ hypoglycemia. Dika ihe omumu banyere ogwu, ya na data banyere iji ogwu a ka eweputara ya na ahia, onodu nke hypoglycemia di iche na ndi oria di iche iche, site na usoro onunu ogwu di iche iche na uzo nke njikwa glycemic (lee ozi n’okpuru).

Na mbido insulin ọgwụ, enwere ike ịhụ njehie ntụgharị, edema na mmeghachi omume na saịtị ịgba ntụtụ (mgbu, redness, urticaria, mbufụt, ọnya ahụ, ọzịza na itching na saịtị ịgba ntụtụ). Mmeghachi omume ndị a na-adịkarị. Ọganiihu ngwa ngwa na nchịkwa glucose ọbara nwere ike iduga n'ọnọdụ a na-agbanwegharị maka neuropathy mgbu nke nnukwu.

Ọganiihu dị mma na njikwa glycemic n'ihi mmụba ọgwụ insulin nwere ike ibute ọrịa nwa oge ịbelata ọrịa mamịrị, ebe njikwa glycemic nke ọma agbatịkwuru na-ebelata ohere ịbawanye nke ọrịa mamị retinopathy.

Dika ihe omumu banyere ogwu, ihe ndi a bu ihe ojoo na udiri oge site na usoro ihe ndi mmadu na ndi ozo.

Dika ugboro ugboro, ihe ndị a mere na-ekewa ndị na-eme oge (≥1 / 10), ọtụtụ mgbe (≥1 / 100 ruo 1/1000 ka A ga-echekwa 1/10000 ruo N 30 NM na friji na okpomọkụ nke 2 - 8 Celsius C (adịghị oke nso na friza). Emela ifriizi.

Debe akpa nke umu aka umu aka.

Zere ọkụ ma ọ bụ ìhè anyanwụ.

Kalama nke ọ bụla nwere okpu plastik na-echebe, na -eme ka agba Ọ bụrụ na okpu plastik na-echebe anaghị adabaghị na ngwa ngwa ma ọ bụ na-efu efu, a ga-akpọghachi karama ahụ n'ụlọ ahịa ọgwụ.

Ekwesịrị ịchekwa vials Mikstard ® 30 NM nke eji eme ya na friji. Enwere ike idobe ha na ụlọ okpomọkụ (anaghị adị elu karịa 25 Celsius C) maka izu isii mgbe ịmepechara ma ọ bụ maka izu ise na okpomọkụ na-agaghịfe 30 Celsius.

Ekwesighi iji insulin insulin agbajikwa.

Ejila insulin mgbe ụbọchị ngafe nke edepụtara na ngwugwu ahụ.

Mikstard® 30 NM ekwesịghị iji ma ọ bụrụ na, mgbe agwakọtara ọdịnaya nke vial ahụ, mmiri mmiri ahụ anaghị acha ọcha ma dị ọcha igwe ojii.

Omume ọgwụ

Ọ na - emekọrịta ihe na ihe dị mkpa ga - anabata plasma membrane receptor ma banye n’ime sel, ebe ọ na - eme ka phosphorylation nke protein cellular, na - akpali glycogen synthetase, pyruvate dehydrogenase, hexokinase, na-egbochi adipose anụ ahụ lipase na lipoprotein lipase. Na njikọta otu nnabata, ọ na - eme ka glucose na - abanye n’ime sel, na - eme ka nkwalite ya na uru ya na - akwalite ntụgharị na glycogen. Na-eme ka akwara glycogen nwee ike, na-akpali njikọ peptide.

Nchedo nchekwa

Cartridge Penfill bụ maka onwe ya. Mgbe a gbasịrị ya ka ọ dịkarịa ala 6 s, agịga ahụ kwesịrị ịdị n'okpuru anụ ahụ maka ị aụ ọgwụ zuru ezu. Okwesiri iburu n’uche na ikike inya ugboala mgbe ebufe ndi oria n’ime insulin mmadu nwere ike belata nwa oge. Shouldkwesighi iji ọgwụ ahụ ma ọ bụrụ na ịkpalite nkwusioru ahụ anaghị abụ otu.