Dalacin C.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Dalacin. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara ojiji ọgwụ mgbochi Dalacin na omume ha. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Dalacin analogues na ọnụnọ nke usoro analogues dịnụ. Jiri maka ọgwụgwọ nke otutu (otutu), ahụ ọkụ na-acha uhie uhie, tonsillitis na ọrịa ndị ọzọ na ndị okenye, ụmụaka, yana n'oge ime na lactation. Ngwakọta ọgwụ ahụ.

Dalacin - ọgwụ mgbochi ihe mejupụtara nke linksamide otu, guzobere site na lincomycin mgbe e dochiri 7- (R) -hydroxyl otu 7- (S) -chlor, na-arụ ọrụ megide microorganisms nke aerobic gram na otutu nje bacteria anaerobic. Ọtụtụ nje aerobic na-adịghị mma, gụnyere Enterobacteriaceae, na-eguzogide ọgwụ na clindamycin.

Lincosamides, dị ka macrolides (dịka ọmụmaatụ, erythromycin) na-ejikọ ikike nke 50S nke ribosome nje na inhibido protein protein n'oge mmalite. Dabere na nghọta microorganism na ị ofụ ọgwụ ahụ, clindamycin nwere ike ime ihe bacteriostatically (nke kachasị) ma ọ bụ nje ahụhụ (na oke ịta).

Microorganisms ndị a na-ahụ maka clindamycin na vitro:

1. Acobic gram-cocci nke ọma, gụnyere: Staphylococcus aureus, staphylococcus epidermidis (ụdị na-amịpụta ma na-adịghị emepụta penicillinase). Achọpụtara ya (in vitro) mmepe ngwa ngwa nke nguzogide clindamycin n'ụdị ụfọdụ nke starylococcal erythromycin. Ike kọmputa spp. (ewezuga Streptococcus faecalis), Pneumococcus spp.

2. Anaerobic gram-bacilli na-adịghị mma, gụnyere: Bacteroides spp. (gụnyere otu nke B. fragilis, B. disiens, B. bivius na B. melaninogenicus), Fusobacterium spp.

3. Anaerobic, gram-positive, na-abụghị spore akpụ bacilli, tinyere Propionibacterium spp., Eubacterium spp., Actinomyces spp.

4. Anaerobic na microaerophilic gram-cocci-cocci, gụnyere Peptococcus spp., Peptostreptococcus spp., Microaerophilic Streptococcus spp., Clostridia spp.: Clostridia na-eguzogide clindamycin karịa ka ọtụtụ anaerobes ndị ọzọ. Imirikiti ndị na-ahụ maka Clostridium na-enwe mmetụta na clindamycin, mana ụdị ndị ọzọ, dị ka C. sporogenes na C. tertium, na-abụkarị ndị na-eguzogide ọgwụ na clindamycin, ya mere a ga-enwerịrị nnwale nke ọgụgụ isi.

5. Ihe dị iche iche, gụnyere Chlamydia trachomatis, Toxoplasma gondii, Plasmodium falciparum na Pneumocystis carinii (ya na primaquin), Gardnerella vaginalis, Mobiluncus mulieris, Mobiluncus curtisii, Mycoplasma hominis.

Microorganisms ndị na-esote na-abụkarị ndị na-eguzogide ọgwụ na clindamycin: aerobic gram-bad bacilli Streptococcus faecalis, Nocardia spp., Neisseria meningitidis, nsogbu nke staphylococcus aureus na-akpata Methicillin na-enwe na ụdị ọrịa nke Haemophilus influenzae. Mgbochi nguzogide n'etiti lincomycin na clindamycin.

Ngwakọta

Ndị na-agụ akwụkwọ Clindamycin.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, mmịpụta ngwa ngwa na ihe fọrọ nke nta (90%) nke dalacin na-apụta. Mgbe a na -ekwu ya ọnụ, nnabata clindamycin (nke buru ibu) anaghị ịdabere na ntụtụ nri n'otu oge, mana ịbanye na nri nwere ike belata ịmịcha. Enwere mmekọrịta kwụ ọtọ n'etiti ịta clindamycin na ọbara yana nke ọgwụ a .ụrụ. 40-90% nke ọgwụ enyere aka na-ejikọ ndị na-edozi ahụ. Clindamycin abanyeghị na mgbochi ụbụrụ na-arụ ọrụ (BBB) ​​(ọbụlagodi iwe ọkụ nke meninges, permeability na-abawanye ntakịrị). Na ụdị agbanweghi, ihe dị ka pacenti iri ọgwụ ahụ wepụtara n'ahụ mmadụ site na akụrụ, 3.6% - yana ọrịa anụ ahụ. A na-ewepụta ego fọdụrụ dị ka metabolites na-adịghị arụ ọrụ, tumadi na bile na feces. Achọghị Clindamycin site na njikọta akwara ụkwụ na akwara ọwụwa.

Ihe na-egosi

Ọrịa na-efe efe nke mkpụrụ ndụ anaerobic na-emetụta clindamycin ma ọ bụ ụdị nke nje aerobic gram-positive, dịka Streptococcus spp., Staphylococcus spp. na Pneumococcus spp., yana clindamycin nwere mmetụta Chlamydia trachomatis serovars:

• ọrịa akụkụ akụkụ okuku ume na elu, gụnyere tonsillitis, pharyngitis, sinusitis,
• ọzịza nke etiti, ọnya uhie,
• ọrịa nke ala akụkụ okuku ume na akụkụ, gụnyere ngwo, ponia, empyema nke pleura na ngụgụ,
• ọrịa na-efe efe nke anụ ahụ na anụ ahụ dị nro, gụnyere akpịrị (akpịrị), furunculosis, ọrịa nke subcutaneous fat, impetigo, ọnya, ọnya nje, usoro nje na-efe efe na anụ ahụ yana anụ dị nro nke ọrịa na-ebute na ọgwụ a, dịka erysipelas na paronychia (panaritium),
• ọrịa na-efe efe nke ọkpụkpụ na nkwonkwo, gụnyere osteomyelitis na ọrịa ogbu na nkwonkwo,
• ọrịa na-efe efe, gụnyere endometritis, ọrịa nke abụba subcutaneous, ọrịa nke anụ ahụ gbara gburugburu akwara, ọrịa ọnya afọ na akwara, salpingitis na ọrịa nke akụkụ ahụ pelvic, yana ọgwụ ọgwụ nje na-arụ ọrụ megide ọrịa gram-negative aerobic pathogens (e.g. ladamicin),
• monotherapy nke ọrịa ọnya nke Chlamydia trachomatis kpatara,
• ọrịa na-efe efe nke eriri afọ, gụnyere peritonitis na ọnụnọ nke eriri afọ (yana ọgwụ ndị ọzọ na-egbochi nje na-eme ihe na nje gram na-adịghị mma),,
• ọrịa mbufụt na endocarditis,
• dị ka ọnya ọgbụgba na ọnya na-egbu egbu, dị ka ọnụnọ nke oge na oge ọgbụgba,
• toxoplasma encephalitis na ndị ọrịa AIDS (yana pyrimethamine na ndị ọrịa nwere ntachi obi na usoro ọkọlọtọ),
• Ọrịa pneumocystis na ndị ọrịa AIDS (yana yana primaquine na ndị ọrịa nwere ekweghị ha nọrọ ma ọ bụ na-eguzogide ọgwụ ọkọlọtọ),
• malaria, incl. kpatara Plasmodium falciparum nke ọtụtụ, ma n'ụdị nke monotherapy, yana yana quinine ma ọ bụ chloroquine,
• mgbochi nke endocarditis na ọrịa ndị na-amụba amụba nke penicillins,
• nje na-akpata nje.

Dị Mwepụta

Capsules 150 mg na 300 mg (mgbe ụfọdụ, a na-akpọ ya mbadamba, mbadamba).

Supplementitor vaginal 100 mg Nke 3.

Gel maka iji mpụga 1% (Dalacin T).

Vaginal cream 3% (mgbe ụfọdụ, a na-akpọ ya ude mmanụ).

Ngwọta maka nchịkwa mgbochi intramuscular (Dalacin Ts phosphate) (injections in ampoules for injection).

Ntuziaka maka usoro na usoro onunu ogwu

Iji zere nsogbu, tinye ọgwụ siri ike nke dọkịta nyere ya.

Ndị okenye: 600-1800 mg / ụbọchị ọnụ na 2, 3 ma ọ bụ 4 doses (doses hà).

:Mụaka: 8-25 mg / n'arọ ahụ mmadụ / ụbọchị site na ọnụ na usoro onyonyo 3-4 (doses hà).

Iji zere iwe nke esophagus, a ga-eji iko mmiri zuru ezu were okpu ahụ.

Ọ bụrụ na gbakọọ maka ọnụọgụ bụ otu dose dị ala karịa ihe clindamycin dị na capsule ma ọ bụ enwere nsogbu ilo ihe, a ga-atụ aro ụdị parenteral nke ọgwụ ahụ.

Ọrịa nke beta-hemolytic streptococcus: a na-egosipụta doses dị n'elu, a ga-aga n'ihu ọgwụgwọ ọ dịkarịa ala ụbọchị 10.

Ọrịa na-efe efe na mbufụt nke akụkụ ahụ nke pelvic: 900 mg iv clindamycin kwa awa 8 + iv kwesịrị ka ọ bụrụ ọgwụ nje na - arụ ọrụ megide gram-aerobic pathogens (dịka ọmụmaatụ, gentamicin na dose nke 2.0 mg / kg nke 1.5 mg / kg sochiri. awa asatọ ọ bụla maka ndị ọrịa nwere ọrụ mkpo nkịtị), ọ dịkarịa ala ụbọchị 4, ma mgbe ọnọdụ onye ọrịa nọ ka ọ dị mma, ọ dịkarịa ala awa 48. Mgbe ahụ, ha na-agbanwe gaa na clindamycin n'ime 450-600 mg kwa awa 6 kwa ụbọchị. Usoro ọgwụgwọ zuru oke bụ ụbọchị 10-14.

Chlamydia trachomatis na-efe efe nke cervix uteri: 450-600 mg nke ọnụ 4 ugboro kwa ụbọchị maka ụbọchị 10-14.

Toxoplasmosis encephalitis na ndị ọrịa AIDS: n'ime ndị ọrịa na-anabataghị ọgwụgwọ nkịtị, a na-eji clindamycin eme ihe na atụmatụ pyrimethamine dị ka usoro: 600-1200 mg ọnụ 6 ọ bụla maka izu abụọ, mgbe ahụ, a na-agbanye 300-600 mg ọnụ na awa 6 ọ bụla. -75 mg ọnụ kwa ụbọchị. N’ezie, usoro ọgwụgwọ bụ izu 8-10. Mgbe ị na-eji ọgwụ silrimethamine dị elu, ekwesịrị ịkọwa folinic acid na dose nke 10-20 mg / ụbọchị.

Pneumocystis na-efe efe na ndị ọrịa bu oria: 300-450 mg ọnụ kwa ụbọchị 6 maka ụbọchị 21 na primaquine 15-30 mg nke ọnụ otu ugboro kwa ụbọchị maka ụbọchị 21.

Otito streptococcal tonsillitis / pharyngitis: 300 mg ọnụ ugboro abụọ kwa ụbọchị maka ụbọchị iri.

Ọrịa ịba: 10-20 mg / kg / ụbọchị ọnụ maka ndị okenye yana 10 mg / n'arọ / ụbọchị maka ụmụaka kwa awa iri na abụọ n'ogo ọ bụla maka ụbọchị 7 dị ka monotherapy, ma ọ bụ na jikọtara ya na quinine (12 mg / kg kwa awa 12) ma ọ bụ chloroquine (15-25 mg kwa awa 24) maka ụbọchị 3-5.

Mgbochi nke endocarditis na ndị ọrịa nwere ọrịa penicillins: 600 mg site na ọnụ maka ndị okenye na 20 mg / kg maka ụmụaka 1 awa tupu obere ịwa ahụ ma ọ bụ ịwa ahụ eze ma ọ bụ usoro ọ bụla ọzọ metụtara ihe ize ndụ nke endocarditis.

Ndị ọrịa agadi: ọ dịghị mkpa ịgbanwe usoro a na ọrụ nkịtị (maka oge enyere ya) imeju na akụrụ.

N'aka. A na-etinye akwa oyi akwa na mpaghara ahụ emetụtara anụ ahụ dị ọcha ugboro abụọ n'ụbọchị. Iji nweta nsonaazụ na-eju afọ, a ga-aga n'ihu ọgwụgwọ maka izu 6-8, ma ọ bụrụ na ọ dị mkpa, ịnwere ike ịga n'ihu ruo ọnwa 6.

A na-etinye otu mkpụrụ (1 onye na-achọ ihe zuru ezu (5 g nke ude, ihe dị ka 100 mg nke clindamycin) n'ime ikpu, ọkacha mma n'oge akwa ụra, maka ụbọchị 3 ma ọ bụ 7.

N'ime ngwugwu nwere ude 20 g enwere ndị na-achọ plastik 3, na ngwugwu nwere 40 g enwere ndị chọrọ ntinye aha 7 maka nnabata ziri ezi nke ude n'ime nwanyị.

Iwu nke iji ọgwụ eme ihe

1. Wepu okpu nke tube nke ude. Kpoo ihe mkpuchi rọba wee kegide eriri nke ọkpọ ahụ.
2. Mgbe ị na-atụgharị ọkpọ ahụ site na njedebe nke ọzọ, jiri nwayọọ kpochaa ude ahụ n'ime onye chọrọ. Onye tinyere ya juru eju mgbe pistin ya ruru na nkwụsị.
3. Kwupu onye na-etinyere ya okwu si n’uwe ma kechie okpu.
4. Ka ị na-edina n’elu azụ gị, kpụọ ikpere gị n’obi gị.
5. Jide onye na-etinye ya n'usoro, jiri nwayọ tinye ya n'ime obosara dịka o kwere mee, na-enweghị mmetụ ahụ adịghị mma.
6. Jiri nwayọ na-agbanye pistin ahụ, fanye ude n'ime ikpu.
7. Jiri nwayọ wepu onye na-etinye ya na ikpu ma tufuo ya.

Mmetụta akụkụ

• mgbu afọ
• ọgbụgbọ, vomiting,
• afọ ọsịsa
• esophagitis
• ọnya afọ
• ọnya na-efe efe,
• dysbiosis,
• maculopapular rash,
• urticaria
• itching
• juputara na ihe na-efe efe nke dị nfe na-agafe agafe,
• erythema multiforme,
• exfoliative na vesiculo-bulrem dermatitis,
• necrolysis na-egbu egbu
• mmeghachi omume anaphylactoid
• kwuru na enwere njikọ neutropenia (leukopenia) na eosinophilia nke ọdịdị na-agafe agafe,
• vaginitis
• mmepe nke superinfection.

Ihe ngbanwe

• hypersensitivity na clindamycin, lincomycin ma ọ bụ akụkụ ọ bụla nke ọgwụ ahụ.

Ime na lactation

Clindamycin na-agafe Plasenta. Mgbe iwebata ọtụtụ usoro ọgwụ ahụ, ịta mmiri ọmụmụ mmiri bụ ihe dịka 30% nke ịta ọbara ọbara nne. Ekwesịrị iji Clindamycin n'ime ụmụ nwanyị dị ime naanị ma ọ bụrụ na ebumnuche ebumnuche ya na nne ya karịrị akarị n'ihe nwa ebu n’afọ. A na-ahuta Clindamycin na mmiri ara ara na nzukota nke 0.7-3.8 μg / ml.

Ọ bụrụ na ọ dị mkpa, ịha n ’oge a ga-ahapụ ya ga-akwụsị inye ya ara.

Ntụziaka pụrụ iche

N'ihe banyere ọrịa ọnya nke Chlamydia trachomatis kpatara, clindamycin monotherapy dị irè maka ọgwụgwọ zuru oke.

A hụrụ ọrịa pseudomembranous colitis nke ịdị iche iche ruo ọnwụ na-egbu ndụ site na iji ihe fọrọ nke nta ka ọ bụrụ ọgwụ nje niile, gụnyere Dalacin, ya mere, n'ọnọdụ niile nke afọ ọsịsa mgbe ị drugsụsịrị ọgwụ nje, a ga-atụle ohere nke nchọpụta a. Ọgwụ nje ndị na-egbu egbu na-egbochi ụmụ irighiri ahịhịa dị na ya, nke nwere ike itinye aka na ụba ịmụpụta nke clostridia. Ekwuputala na toxins nke Clostridium difficile mepụtara bụ ihe bụ isi na-akpata colitis jikọtara ya na ọgwụ nje. Ọrịa pseudomembranous colitis nwere ike ime ma mgbe ị na-ewere clindamycin, na izu 2-3 mgbe ọ kwụsịrị ọgwụgwọ, a na-egosipụta ya site na afọ ọsịsa, leukocytosis, ahụ ọkụ, ọnya afọ (mgbe ụfọdụ na-eso ya site na excretion na fecal ọbara na imi). Mgbe achọpụtara ọrịa pseudomembranous colitis na ọnọdụ dị nro, ọgwụgwọ na iji ion mgbanwe resins (colestyramine, colestipol) zuru ezu iji kagbuo, n'ọnọdụ dị njọ na n'ọnọdụ siri ike, nkwụghachi ụgwọ maka ọnwụ nke mmiri, electrolytes na protein, nhọpụta nke ọgwụ antibacterial dị irè megide Clostridium mgbasa, dịka ọmụmaatụ, vancomycin na ọgwụ nke 125-500 mg, ma ọ bụ bacitracin na dose nke 25,000 IU n'ime ugboro 4 kwa ụbọchị maka ụbọchị 7-10, ma ọ bụ metronidazole 250-500 mg ugboro atọ n'ụbọchị. Ọgwụ nke na-ebelata eriri afọ ekwesịghị ịnwe ọgwụ n’otu oge na clindamycin.

Mgbe ị na - eji ọgwụ nje niile, gụnyere clindamycin, uto nke microorganisms na - enweghị mmetụta na ọgwụ a, karịsịa yist-fungi fungi, ga - ekwe omume. Site na mmepe nke superinfection, a ga-ewere usoro kwesịrị ekwesị dabere n'ọnọdụ ọnọdụ.

Ekwesighi inye ọgwụ Clindamycin maka ịgwọ ọrịa meningitis, ebe ọ na-abanye n’adighi ike site na mgbochi ụbụrụ ọbara (BBB).

Mgbe ị na-ede ọgwụ ahụ n'ọtụtụ oke, ọ dị mkpa iji chịkwaa ịta clindamycin na plasma. Ọ bụrụ na a na-eme ọgwụgwọ ahụ ogologo oge, mgbe ahụ a ga-eme nnwale ọrụ imeju na akụrụ.

N'ime ndị ọrịa nwere ọria imeju na akụrụ, ọ dịghị mkpa ịgbanwe sọọsọ ọgwụ ahụ, ebe ọ bụ na clindamycin fọrọ nke nta anaghị agbakọ n'ime ahụ ma ọ bụrụ na ejiri ọgwụ ahụ were ọnụ were awa asatọ.

Mkparịta ụka ọgwụ ọjọọ

Emebere ya na inogan anodiiche n’etiti dalacin na erythromycin. Ebe ọ bụ na ịlụ ọgụ a ga - adị oke mkpa, ọgwụ ndị a ekwesịghị ịgwụ otu oge. Enwere ihe akaebe nke mmekorita yiri nke ya na chloramphenicol.

E guzobela na Dalacin na-akpaghasị mgbasa nke neuromuscular ma, yabụ, nwere ike ịkwalite nsonaazụ ndị ọzọ na-eme ka ahụ ghara ịdị ala, yabụ, ekwesịrị iji ọgwụ a kpachara anya na ndị ọrịa na-anata ọgwụ ndị otu a.

Ojiji nke analọgị opioid (narcotic) n'otu oge, nke nwere mmetụta dị n'etiti ọrụ na iku ume, nwere ike ibute ịda mmụọ nke akpịrị ruo mgbe akwara.

Oge nchịkwa nke oge ọgwụ ọgwụ antidiarrheal na-ebelata mgbatị gastrointestinal na-abawanye ohere nke pseudomembranous colitis.

Aminoglycosides na-agbasa ụdị dị iche iche nke ọgwụ antimicrobial nke clindamycin.

Analogs nke ọgwụ ọgwụ Dalacin

Anakpụrụ nke analogues nke na-arụ ọrụ:

• Dalacin C fosifeti,
• Zerkalin,
• Klimitsin,
• Clindamycin,
• Klindatop,
• Klindafer
• Clindacin
• Klines,
• Klindovit.

Ihe ngosi maka ojiji

Ọrịa bakteria na-akpata site na microorganisms nwere mmetụta: nje nke akụkụ ENT (gụnyere tonsillitis, pharyngitis, sinusitis, media otitis), ọrịa na-efe efe (bronchitis, oyi baa, akpa ume na-adịghị ala ala, filorosing alveolitis), ọrịa nke ọkpụkpụ na nkwonkwo () osteomyelitis, ọrịa ogbu na nkwonkwo, ọnya na-efe efe nke anụ ahụ na anụ ahụ dị nro (gụnyere akpịrị, boils, phlegmon, impetigo, panaritium, ọnya ndị metụtara, ọnya afọ, erysipelas), sepsis (nke bụ oria anaerobic), ọrịa pelvic na intraperitoneal na-efe efe ( gụnyereperitonitis, etuto nke akụkụ nke afọ na nke imekota aru nke ogwu eji eme ihe megide gram-odi aerobic ụmụ nje), ọrịa gynecological (endometritis, adnexitis, colpitis, ọnya afọ nke akụkụ fallopian na ovaries, salpingitis, pelvic peritonitis), ọrịa nke onu ura (gụnyere timontal etuto), toxoplasma encephalitis, ịba (nke Plasmodium falciparum kpatara), oyi baa (nke Pneumocystis carinii), sepsis, endocarditis, chlamydia, fever na-efe efe, diphtheria.

Mpempe usoro onunu ogwu

Capsules 150 mg, 300 mg

Otu Capsule nwere:

ike ihe - clindamycin hydrochloride 177.515 mg ma ọ bụ 355.030 mg (nke ya na clindamycin 150 mg ma ọ bụ 300 mg),

ndị mbụ: magnesium stearate, stachi ọka, talc, lactose monohydrate,

mejupụtara shesu shesu: titanium dioxide (E 171), gelatin.

Cappales siri ike opaque gelatin nwere mkpuchi na ahụ ọcha, ink dee ede "Pfizer" yana koodu "Clin 150". Ihe ndị dị na capsules bụ ntụ ntụ (maka ọgwụ nke 150 mg).

Cappales siri ike opaque gelatin nwere mkpuchi na anụ ahụ na-acha ọcha, ink ink gbara akwụkwọ "Pfizer" na koodu "Clin 300". Ihe dị na capsules bụ ntụ ntụ (maka ọgwụ nke 300 mg).

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, clindamycin na-agbakarị ngwa ngwa, ọ fọkwara nke nta ka ọ banye gị (90% nke ọgwụ a na-ewere).

Iri nri otu oge, emetụtaghị ị ofụ ọgwụ ọjọọ na plasma ọbara.

Ogige

N'ime ndị okenye nwere ahụike, ọnụ ọgụgụ plasma kachasị elu bụ ihe dịka 2-3 mg / L ma a na-ahụ ya otu elekere mgbe nchịkwa ọnụ nke 150 mg nke clindamycin hydrochloride ma ọ bụ 4-5 mg / L mgbe nchịkwa ọnụ nke 300 mg. Mgbe ahụ, nsị plasma na-eji nwayọ daa, na-anọgide karịa 1 mg / L maka ihe karịrị awa 6. Nleta Plasma na-abawanye n'usoro dị larịị dị ka mmụba nke ọgwụ a na-agbaso. A na-akọ ọnụọgụ ọbara dị ka ndị ọrịa na-arịa ọrịa shuga dịtụ ala karịa ndị ọrịa nwere ahụike. Ọkara ndụ ọkara nke clindamycin sitere na ọbara bụ awa 2,5.

Ihe Platoma Platinma

Indmịnye protein ndị dị na plasma sitere na 80 ruo 94%.

Ọkpụkụ anụ ahụ na mmiri

A na-ekesa Clindamycin n'ọtụtụ ebe dị ukwuu na mmiri extracellular na intracellular yana akwara. Ọkpụkpụ n’ime mmiri mkpụrụ mmiri cerebrospinal dị ụkọ.

Clindamycin bụ metabolized na imeju.

Ihe dị ka 10% nke ọgwụ dị n'ụdị arụ ọrụ ka ewepụrụ na mmamịrị ma 3.6% dị n'ime ahụ. Ihe ndị ọzọ fọdụrụ dị ka metabolites na-adịghị ejekwa ozi.

Ọkpụkpụ ọbara clindamycin adịghị agbanwe n'ihi nsonaazụ akwara ụkwụ ma ọ bụ mgbawa peritoneal.

Mlọ ọgwụ

A na-eji oke uche ndị na-eso nke ncheta ihe inhibitory kacha nta (MIC) dị iche iji mata ọdịiche dị n'etiti mkpụrụ ndụ nwere ike ịnagide ya, yana ihe mgbochi nwere etiti na mkpụrụ ndụ na - egbochi nkwụsi ike site na mkpụrụ ndụ na - eguzogide ọgwụ:

S ≤ 2 mg / L na R> 2 mg / L.

Ọnụnọ nke nguzogide nwere ike ịdị iche maka ụfọdụ ụdị dabere na mpaghara ala na oge na-aga, ọ dịkwa mma ịnwe ozi banyere njirimara mpaghara nke juputara na nguzogide, karịchaa n'ịgwọ ọrịa ndị siri ike. Ihe omuma a na-enye echiche di nkpa banyere ike o nwere ike ịdị n ’ihe nje ndị a na ọgwụ nje a.

Gram-positive cocci, gụnyere:

-Ike abụghị otu n'ime ndị otu ahụ

Gram-adịghị mma bacilli, gụnyere:

Gram odi njoaerobicnje

-Akpọghị eregram adịghị mmabacilli

Clindamycin na-egosi ọrụ in vitro na na vivo megide Toxoplasma gondii.

* Mgbasa nke nguzogide methicillin bụ ihe dịka 30 ruo 50% maka staphylococci niile, a na-ahụkarị ya na ọnọdụ ụlọ ọgwụ.

Usoro onunu ogwu na nhazi

A na-eji ọgwụ ahụ eme ihe n'ime, iji zere iwe nke esophagus, a ga-eji iko mmiri zuru ezu hichaa capsules ahụ (250 ml).

Ọgwụ kwa ụbọchị bụ 600- 1800 mg / ụbọchị, kewara 2, 3 ma ọ bụ 4 usoro dokwara. Oke kachasị kwa ụbọchị bụ 2400 mg.

Ọrịa ụmụaka

Usoro onunu ogwu nke 8-25 mg / n'arọ kwa ụbọchị, kewara n'ime 3 ma ọ bụ 4 doses hà.

Ekwesiri iji umuaka mee ihe ma oburu na ha nwere ike ilo ahihia niile.

Ndị okenye na-arịa ọrịa

Nnyocha Pharmacokinetic mgbe nchịkwa ọnụ na nchịkwa nke clindamycin ekpugheghị ọdịiche dị mkpa dị n'etiti ndị ọrịa na-eto eto na ndị agadi nwere ọrụ imeju na ọrụ nkịtị (na-eburu n'uche afọ ọrụ) gbasara akụrụ. N'akụkụ a, mmezi dose n'ime ndị ọrịa agadi nwere ọrụ imeju na arụ ọrụ ọ dị mma (na-eburu afọ) anaghị arụ ọrụ ezumike.

Ndị ọrịa nwere ọrụ mgbazinye nsogbu

N'ime ndị ọrịa nwere ezughi oke gbasara akụrụ, a chọghị idozi dose nke clindamycin.

Ndị ọrịa nwere ọria imeju

N'ime ndị ọrịa nwere ọrịa ịba ọcha n'anya, ọ dịghị mkpa ka ịgbanwere sụgharịa nke clindamycin.

Usoro onunu ogwu maka ihe puru iche

Ọgwụ maka Beta Hemolytic Streptococcus Injection

Atụmatụ usoro usoro ọgwụgwọ ahụ kwekọrọ na usoro a dị elu maka ndị okenye na ụmụaka. Ekwesịrị ịga n'ihu na ọgwụgwọ ọ dịkarịa ala ụbọchị 10.

Ọgwụ nke tonsillitis na-arịa oke ma ọ bụ pharyngitis

Usoro a tụrụ aro bụ 300 mg ugboro abụọ kwa ụbọchị maka ụbọchị iri.

Inupatient ọgwụgwọ ọrịa mkpali nke akụkụ ahụ aka

Usoro ọgwụgwọ ahụ kwesịrị ịdị site na iji ọgwụ mgbochi intanyere ogwu Dalacin C Phosphate (na dose 900 mg kwa elekere 8 na mgbakwunye na ọgwụ mgbochi intravens na ihe ngosi dị iche iche megidere gram-ọjọọ aerobic microorganisms, dịka ọmụmaatụ, na Gentamicin na dose nke 2.0 mg / n'arọ, sochiri dose nke 1.5 mg / kg kwa awa 8 n'ime ndị ọrịa nwere ọrụ ezumike nkịtị). A ga-aga n’ihu n’ime ọgwụgwọ ọgwụ iji gbarụọ ụbọchị 4 ma ọ dịkarịa ala awa iri anọ na asatọ ka ọnọdụ onye ọrịa ahụ ka mma.

Mgbe ahụ, ị ​​ga-aga n'ihu na-ewere ọgwụ Dalacin® na ọgwụ nke 450-600 mg kwa elekere isii kwa ụbọchị ruo mgbe emechara usoro ọgwụgwọ jiri ngụkọta oge nke 10-14 ụbọchị.

Ọkpụkpụ na nkwonkwo na-efe efe

Usoro a tụrụ aro bụ 7.5 mg / kg kwa awa 6.

Mgbochi nke endocarditis na ndị ọrịa nwere uche penicillin

N'ime ndị ọrịa okenye, ọgwụ a tụrụ aro ya bụ 600 mg 1 awa tupu usoro ahụ; ụmụaka: 20 mg / kg 1 awa tupu usoro ahụ.

Mwepụta wepụtara ya na ihe mejupụtara

Dalacin dị n'ụdị usoro usoro ọgwụgwọ a:

• Ọrịa maka ihe mpụga 1%: transperent, na enweghị agba, viscous (30 g ọ bụla n'ime akpa, 1 tube na kaadiboodu),
• Ude na-acha uhie uhie 2%: ọcha (20 ma ọ bụ 40 g nke ọ bụla na tube nke polyethylene ma ọ bụ aluminom foil zuru ezu na ndị na-achọ 3 ma ọ bụ 7 (n'otu n'otu, na atọ n'ime igbe kaadi),
• Capsules: gelatinous, siri ike, ya na ya na mkpuchi ọcha, akpọrọ “P&U 225” (150 mg nke ọ bụla) ma ọ bụ “P&U 395” (300 mg nke ọ bụla), ihe dị na capsules ahụ bụ ntụ ntụ (pọọlụ 8 ma ọ bụ 10). 2 ma ọ bụ blister na igbe kaadi),
• Arịa anụ ahụ: torpedo, nke siri ike, nwere ezigbo ala, ọ fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha (kọntaktị 3. Na mpempe akwụkwọ laminated na ma ọ bụ na-etinye ya, 1 mpempe akwụkwọ na kaadiboodu).

Ngwakọta nke gel mg 1000 mg maka iji mpụga:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị phosphate) - 10 mg,
• Ihe ntinye aka: methyl paraben - 3 mg, allantoin - 2 mg, polyethylene glycol - 100 mg, propylene glycol - 50 mg, carbomer 934P - 7.5 mg, ihe ngwọta nke 40% sodium hydroxide - na ọnụ ọgụgụ zuru ezu, mmiri dị ọcha - na ọnụ ọgụgụ zuru ezu ruo 1000 mg .

Ihe mejupụtara ude ude 1000 mg:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị phosphate) - 20 mg,
• Ihe ntinye aka: cetyl palmitate - 32.1 mg, stearic acid - 21.4 mg, polysorbate 60 - 50 mg, sorbitan monostearate - 20 mg, propylene glycol - 50 mg, mmanya benzyl - 10 mg, cetostearyl mmanya - 32.1 mg, mineral mmanụ - 64.2 mg, mmiri dị ọcha - na ọnụ ọgụgụ zuru ezu.

Ngwakọta 1 Capsule:

• Ihe na-arụ ọrụ: clindamycin (n'ụdị hydrochloride) - 150 ma ọ bụ 300 mg,
• Ihe inyeaka: talc, lactose, ọka ọka, magnesium stearate, gelatin, titanium dioxide.

Ọdịdị nke 1 nke nwanyị:

• Ihe nọ n'ọrụ: clindamycin (n'ụdị phosphate) - 100 mg,
• Ihe inyeaka: abụba siri ike (Witepsol H-32, ngwakọta nke monoglycerides, diglycerides na triglycerides) - ihe dị ka 2400 mg.

Ihe ngbanwe

A na-etinye Dalacin na ọnụnọ nke ịgwọ ọrịa na clindamycin, lincomycin ma ọ bụ ihe enyemaka nke ọgwụ.

Ọgwụ a n'ụdị capsules kwesịrị iji nlezianya mee ihe na ndị ọrịa nwere eriri afọ (akụkọ ihe mere eme), ọkachasị na ọnya akwara, myasthenia gravis (ikekwe nyefe ọbara neuromuscular nke ukwuu), akwara imeju.

Na mgbakwunye, Dalacin n'ụdị usoro usoro ọgwụgwọ ndị ọzọ ka a machibidoro ọrịa / ọnọdụ ndị a:

• Akụkọ banyere ọgwụ nje na-akpakọrịta,
• Afọ: ruo afọ iri na asatọ maka ude na oke, ruo afọ iri na abụọ maka gel maka iji mpụga (enweghị data banyere ịdị irè na nchekwa nke Dalacin na otu ndị ọrịa a),
• Hypersensitivity na lincomycin ma ọ bụ clindamycin na anamnesis (maka gel maka mpụga).

Usoro onunu ogwu na nhazi

Dalacin n'ụdị capsule ka a na-ewere ọnụ. Iji zere nsogbu, a na-atụ aro ka iji ya eme ihe kpamkpam dịka dọkịta nyere ya.

Iji zere iwe nke akpụkpọ ahụ mucous nke esophagus, a ga-eji iko mmiri jupụta capsules.

A na-ejikarị ọgwụ ahụ:

• Ndị okenye: 600-1800 mg kwa ụbọchị, ugboro ole nchịkwa - ugboro 2-4 (na usoro dokwara),
• :Mụaka: 8-25 mg / n'arọ nke anụ ahụ kwa ụbọchị, ugboro ole nchịkwa bụ ugboro 3-4 (na doses hà).

N'ime ọgwụgwọ nke ọrịa nje beta-hemolytic streptococcus, a na-eji Dalacin mee ihe ndị a kọwara n’elu. Oge oge ọgwụgwọ dịkarịa ala, ọ dịkarịa ala ụbọchị 10.

Ọgwụ nke ọrịa na-efe efe na ọnya nke akụkụ ahụ pelvic na-amalite site na nchịkwa intravenous nke clindamycin, n'ọtụtụ nke 900 mg kwa elekere 8, n'otu oge na onye nnọchi ọgwụ nje kwesịrị ekwesị maka opekata mpe 4. Mgbe ọnọdụ onye ọrịa ahụ dị mma, a na-aga n'ihu ọgwụgwọ maka ọ dịkarịa ala ụbọchị 2 ọzọ, mgbe nke ahụ gasịrị, edepụtara Dalacin n'ụdị capsules n'otu ọgwụ 450-600 mg. A na-a drugụ ọgwụ ahụ kwa ụbọchị kwa awa 6. Usoro ọgwụgwọ zuru ezu bụ ụbọchị 10-14.

Dabere na akaebe ahụ, a na-enye ọgwụ Dalacin:

• Toxoplasmosis encephalitis na ndị ọrịa AIDS: ọ bụrụ na anabataghị ọgwụgwọ nkịtị, a na-ewere ọgwụ ahụ n'otu oge na pyrimethamine dịka atụmatụ a: Dalacin - 600-1200 mg kwa elekere 6 maka ụbọchị 14, mgbe ahụ 300-600 mg na otu ugboro ojiji, pyrimethamine - kwa ụbọchị 25 -75 mg. Dịka iwu, usoro ọgwụgwọ bụ izu 8-10. Mgbe ị na-eji pyrimethamine na usoro onunu ogwu, 10-20 mg nke folic acid kwa ụbọchị kwesịrị ka edee,
• Ọrịa akwara sitere na Chlamydia trachomatis: 450-600 mg kwa ụbọchị, usoro onunu ogwu ugboro 4 kwa ụbọchị, oge ọgwụgwọ 10-14 ụbọchị,
• Ọrịa streptococcal pharyngitis / tonsillitis: maka ụbọchị 10, 300 mg ugboro 2 n'ụbọchị,
• Ọrịa pneumocystis na ndị ọrịa AIDS: maka ụbọchị 21, 300-450 mg kwa elekere 6 n'otu oge na primaquine, 15-30 mg otu ugboro n'ụbọchị.
• Ọrịa ịba: ndị okenye - 10-20 mg / kg kwa ụbọchị, ụmụaka - 10 mg / kg kwa ụbọchị. A na-a drugụ ọgwụ ahụ nhata nha ọ bụla awa iri na abụọ ọ bụla, oge ọ gbasoro bụ ụbọchị asaa. O kwere omume iji Dalacin n’otu oge na quinine (awa iri n’abuo iri na abali iri na isii n’arọ obula) ma obu chloroquine (awa iri n’abuo iri ato n’abuo rue iri rue 15-25), oge obula bu ubochi ato.

Maka mgbochi nke endocarditis na ndị ọrịa nwere hyperensitivity na penisiliniins, a na-atụpụrụ Dalacin: maka ndị okenye - 600 mg, maka ụmụaka - 20 mg / kg. Ekwesịrị ị drugụ ọgwụ ahụ ruo otu awa tupu obere ezé ma ọ bụ ịwa ahụ, ma ọ bụ usoro ọ bụla ọzọ nke nwere ihe ize ndụ nke ịmalite ọrịa endocarditis.

Ndị agadi nwere ọrịa gbasara akụrụ na hepatic nkịtị maka oge enyere, yana ndị ọrịa nwere nsogbu imeju na akụrụ, ekwesịghị idozi ọnụọgụ ahụ.

Na ọgwụgwọ nje nje na-enyekarị ọgwụ nje:

• A na-etinye ude ude: 5000 mg nke ude (1 onye na-etinye ihe zuru ezu, ihe dịka 100 mg nke clindamycin) ga-abanye na ikpu. A na-eme usoro ahụ nke ọma tupu alakpu ụra. Oge nkuzi - ụbọchị 3 ma ọ bụ 7,
• A na - enye ọgwụ ike 1 ugboro ugboro kwa ụbọchị, ọkacha mma tupu ị lakpuo ụra. Ọ na-ewe ụbọchị 3.

A na-eji Dalacin n'ụdị nke gel eme ihe na mpụga na ọgwụgwọ nke agbụrụ. A na-etinye ọgwụ ahụ na mpempe akwụkwọ dị mkpa na mpaghara emetụtara (akpọnwụ, anụ dị ọcha). Otutu iji - ugboro 2 kwa ụbọchị. Oge akwadoro ka ọ dị bụ izu asatọ. Dabere na njiri mara, ojiji nke Dalacin ga-ekwe omume maka ọnwa 6. Ọ bụrụ na, mgbe etinyechara gel ahụ ruo ọtụtụ ọnwa, ịdị irè nke ọgwụgwọ na-ebelata, achọrọ izu ike maka izu anọ.

Nsonaazụ

Mgbe ị na-eji Dalacin n'ime, nsogbu ndị ọzọ nwere ike ịmalite:

• Usoro nri: ọgbụgbọ, mgbu afọ, esophagitis, afọ ọsịsa na ọgbụgbọ, ọnya afọ, ọnya afọ, ụdọ, ọnyụnyụ, nsị imeju, tinyere hyperbilirubinemia,
• Hematopoiesis (usoro ọbara): ikpe nke eosinophilia nke ihe na-agafe agafe na leukopenia (neutropenia), yana ikpe nke thrombocytopenia na agranulocytosis, etinyere mmekọrịta dị n'etiti nchịkwa Dalacin na ihe omume ndị a.
• Mmeghachi omume nfụkasị: pruritus, urticaria, maculopapular friji, ọtụtụ mgbe, a na-enwekarị akpịrịkpa na-adịghị ala, na-adịghị ala ala, adịkarịsịrị - vesiculobulous na exfoliative dermatitis, na-egbu egbu epicmal necrolysis, erythema multiforme, mmeghachi omume anaphylactoid,
• Ndị ọzọ: vaginitis.

Ọzọkwa n'oge usoro ọgwụgwọ, mmetụta ndị ọzọ na-esote nwere ike ime: mmepe nke superinfection, nnyefe akwara neuromuscular.

Mgbe ị na -eme ọgwụ nje na Dalacin na ụdị ude na ọgwụ suprimitories, ọ ga - ekwe omume ibute nsogbu site na ụfọdụ sistemu ahụ:

• Sistemụ omumu: vulvovaginitis, candidiasis nwanyị, ọbara ọgbụgba, mgbakasị ihu nke mucous nke ikpu na ọnya ọgbụgba, ọnya ọgbụgba, trichomonas vaginitis, mgbu nwanyị, ịmụ nwa na-enweghị isi, adịghị ahụ nsọ nwoke, mpụta nke nwanyi, endometriosis,
• Usoro ure: urinary tract na-efe efe, dysuria, proteinuria,
• Usoro nri: uto nke uto, flatulence, ọgbụgbọ, afọ ọsịsa, ọgbụgbọ, dyspepsia, afọ ntachi, okeosis, eriri afọ,
• Akpukpo aru: erythema, itching, ihe otutu, akpukpo aru nke akpukpo aru, oke aru nke aru aru, urticaria,
• Sistemụ akwara Central: ọgbụgbọ, isi ọwụwa, vertigo,
• Usoro endocrine: hyperthyroidism, glucosuria,
• Usoro iku ume: ọrịa akụkụ okuku ume na elu, imi,
• Ahụ mmadụ n'ozuzu: ọrịa fungal, nje na-efe efe, bloating, mpaghara na / ma ọ bụ ihe mgbu azụ, obere ihe mgbu nke ime ime, ọnya afọ, mgbagha nke nsonaazụ microbiological site na usoro, azụ mgbu, mmeghachi omume nfụkasị ahụ,
• Mmeghachi omume mpaghara: mbufụt edema na itching na ebe ntụtụ.

Mgbe ị na-etinye gel maka ojiji mpụga, mmetụta ndị ọzọ na-esote nwere ike ime:

• Usoro digestive: colitis, mgbu afọ, ọrịa pseudomembranous, ọrịa dyspeptik (ọgbụgbọ, afọ ọsịsa, vomiting),
• Organ nke anya: na anya na anya,
• Ihe ndi mejuputara: otutu mgbe - akpukpo akpukpo, okpukpo na emeputa ahihia ara, akpukpo aru, urticaria, akpukpo akpukpo akpukpo
• Ndị ọzọ: folliculitis kpatara ahịhịa gram na-adịghị mma.

Ntụziaka pụrụ iche

Site na mmepe nke afọ ọsịsa mgbe etinyere Dalacin ọnụ ma ọ bụ intravaginally, ọ dị mkpa ịtụle ohere nke ịmalite inwe pseudomembranous colitis. Ọrịa ahụ nwekwara ike ịpụta izu 2-3 ka ejedebe ọgwụgwọ. Mgbaàmà ya bụ isi: afọ ọsịsa, leukocytosis, ahụ ọkụ, ọnya afọ (mgbe ụfọdụ tinyere ọnya mmiri na ọbara na ọnya). Ọ bụrụ na ọ dị mkpa, a ga-ewere usoro nyocha na ọgwụgwọ.N'iji ọgwụ a na-eji mpụga, nsogbu nke colitis adịkarịghị, Otú ọ dị, a ghaghị ilezi anya ma, mgbe ọ dị ogologo oge ma ọ bụ nnukwu afọ ọsịsa, a ga-akwụsị iji ojiji nke gel.

Maka ọrịa ọnya nke Chlamydia trachomatis kpatara, capsule monotherapy na Dalacin dị irè maka ọgwụgwọ zuru oke.

Mgbe ị na-ewere Dalacin n'ime, ịba ụba nke microorganisms enweghị mmetụta na ọgwụ ahụ ga-ekwe omume, karịsịa yist-fungi yist. N'ihe banyere superinfection, dabere n'ọnọdụ ọnọdụ ụlọ ọgwụ, a ga-eme ihe kwesịrị ekwesị.

Ekwesighi inye ọgwụ Clindamycin maka ọgwụgwọ ọrịa meningitis.

Mgbe ị na-edepụta Dalacin na usoro dị elu, ịkwesịrị ijikwa mkpokọta clindamycin na plasma. Site na usoro ọgwụgwọ ogologo oge, ekwesịrị ịrụ ọrụ nyocha akụrụ na imeju.

Ekwesiri ịhapụ ọrịa ndị na-esonụ tupu ịdepụta Dalacin maka ọgwụgwọ nke vulvovaginitis: Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Neisseria gonorrhoeae na herpes simplex virus.

Ekwesịrị iburu n'uche na iji ọgwụ eme ihe n'ime intravaginal nwere ike ime ka mmụba nke microorganisms na-enweghị mmetụta na ọrụ ya, karịsịa yist-fungi fungi.

Site na iji ọgwụ intravaginal, ekwesịrị izere inwe mmekọahụ, yana iji ụdị ngwaahịa ndị ọzọ na-eji intravaginally (dịka ọmụmaatụ, sirinji, tampons).

Ekwesighi iji Dalacinin dị ka ude ma ọ bụ suppository n’oge nsọ. Ekwesiri ibido mmalite nke ọgwụgwọ na nke a ruo mgbe njedebe nke nsọ.

Dalacin nwere ihe ndị metụtara ike nke roba ma ọ bụ nke mkpụrụ ọgwụ (ọgwụ mgbochi nwa, alụmụ nwanyị). Iji ọgwụ ndị dị otú ahụ n'oge ọgwụgwọ na n'ime ụbọchị 3 mgbe ị ofụ ọgwụ adịghị akwadoro.

Zere kọntaktị ya na gel maka iji mpụga ya na akpụkpọ ahụ mucous nke ọnụ na anya. Mgbe itinyechara ọgwụ ahụ, sachaa aka gị nke ọma. Ọ bụrụ na kọntaktị na-akpachapụ anya na -echepụta ihu (abrasions na anụ ahụ, anya, mucous akpụkpọ ahụ), jiri mmiri dị jụụ kpochaa kpamkpam.

Mkparịta ụka ọgwụ ọjọọ

Ekwesighi iji okwu ọnụ mee ihe n’otu oge dị ka erythromycin na chloramphenicol.

Enwere mgbochi nke microorganisms na lincomycin na clindamycin.

Ekwesịrị iji nlezianya mee ihe Clindamycin na ndị ọrịa na-anakwere ezumike akwara ndị ọzọ.

Site na iji usoro akụrụngwa nke Dalacin n'ime ime opioid (narcotic) na-enwe mmetụta dị ukwuu na ọrụ akụkụ okuku ume, mmepe nke nkụda mmụọ ọzọ na-aka ruo apnea ga-ekwe omume.

Ihe ize ndụ nke ịmalite nje pseudomembranous colitis na-abawanye site na iji ọgwụ ọgwụ a na-eme ọgwụ antidiarrheal na -ebelata motility gastrointestal.

A na-ahụkarị ọgwụ antimicrobial clindamycin site na aminoglycosides.

A na-atụ aro iji otu ude na ude na ọgwụ ndị ọzọ maka nlekọta intravaginal n'otu oge.

Analogs nke Dalacin bụ: Klindatsin, Klindes, Klindamitsin, Klindovit, Klindatop.

Capsules Dalacin C

Ọnụahịa nke capsules - site na 1324 p.

Capsules nwere talc, lactose na magnesium stearate dịka ihe inyeaka. Na shei jiri stachi, titanium dioxide na gelatin.

Nke mbụ bụ okpu. Ha nwere ike ịbụ mmachi nke 150 ma ọ bụ 350 mg. Capsules siri ike, agba nke ahụ na mkpuchi bụ odo odo ma ọ bụ na-acha ọcha, ụcha nke ntụ ntụ dị n'ime ya na-acha ọcha.

Ngwọta maka ntụtụ

Dalagwọ nke Dalacin C n'ụdị ihe ngwọta maka injection sitere na 587 r kwa ampoule.

N'ime usoro maka inje, ihe ndị ọzọ mmiri bụ mmiri maka injection, disodium edetate, mmanya mmanya benzyl.

Ampoules nwere ike ịnweta 2, 4 ma ọ bụ 6 ml nke ihe ngwọta. Liquid ahụ enweghị odo. Ọ dị n’ime arịa emere iko na-enweghị iko na klaasị m.

Mmekọrịta na ụzọ ndị ọzọ

Ntụziaka maka ọgwụ a na-ekwu na ọ nwere ike imetụta ọgwụ ọgwụ nke ọgwụ ndị ọzọ.

Yabụ, ọ na - enwe ike iwelite nsonaazụ akwara anụ ahụ. Ya mere, iji ọgwụ ndị a na-eme n'otu oge n'okpuru nlekọta siri ike nke dọkịta. A na-edozi usoro ị drugsụ ọgwụ abụọ ahụ n'otu n'otu.

Ọ bụrụ na iji ọgwụ mgbochi afọ na ọgwụ ọgwụ Dalacin C n'otu oge, ihe ize ndụ nke colitis na-abawanye.

Amachibidoro ya iwu iji ngwaahịa a, ntuziaka maka nke a na-atụle n'isiokwu ahụ, yana calcium gluconate, barbiturates, erythromycin, aminophylline, ampicillin, magnesium sulfate.

Nsonaazụ

Mgbe ị na-a theụ ọgwụ, ọtụtụ mgbaàmà na-adịghị mma nwere ike ime.

Treatmentgwọ ọgwụ nje a nwere ike ịkpata:

• Ihe mgbu
• Ogbugbu na vomiting
• Ọrịa afọ ọsịsa
• Ọrịa esophagitis
• Dysbacteriosis
• Thrombocytopenia
• Leukopenia
• Agranulocytosis
• Eosinophilia
• Ọrịa vaginitis
• Akpukpo aru, hives, na itching
• Adị aru
• Dizziness
• Apnea
• Ọbara mgbali elu

N'iji ogologo oge eji capsules, ọnya afọ nwere ike ịmalite.

N'ọnọdụ ndị a na-adịghị ahụkebe, ọgwụ nje nwere ike ịkpalite ọgwụ nje na-egbu egbu.

Mmeghachi omume nfụkasị na ọgwụ ahụ nwere ike gosipụta dị ka ujo anafilas.

Can nwere ike ịmatakwu otu ị ga - esi kwụsị afọ ọsịsa na edemede: ịlụ ọgụ afọ ọsịsa.

Dodoụbiga ya ókè

Edebanyeghị okwu n ’ịdoụbiga mmanya ókè.

Agbanyeghị, ọ bụrụ na ịkwesighi itinye usoro ọgwụgwọ ahụ, enwere ike ịba ụba anaphylactic. Iji kpochapu ya, a na-eji antihistamines na ọgwụ glucocorticoid, yana adrenaline. Ofdị irè nke ịba ọcha n'anya n'oge ihe mmeghachi omume anaphylactic bụ efu. Enweghị ọgwụ mgbochi akọwapụtara na-arụ ọrụ Dalacin C.

Usoro na ọnọdụ nchekwa

Ntụziaka nke ọgwụ na-ekwu na ịkwesịrị itinye ya n'ọnọdụ gbara ọchịchịrị yana iru mmiri dị mma. Oge nchekwa nwere ike ịdị site na 15 ruo 25 Celsius.

Ndụ shelf n'ụdị okpu mkpuchi bụ ọnwa 60.

Ọgwụ a n'ụdị ihe ngwọta maka injections nwere ike iji ya maka ọnwa 24 site na ụbọchị emepụtara.

Akrikhin OJSC (RF) ma ọ bụ Pharmaprim LLC (Moldova)
Ọnụahịa - site na 207 r

Ihe nọ n'ọrụ bụ otu ọgwụ ahụ a na-ekwu okwu ya. A di na udiri nwanyi ma obu ude.

Uru:

• Ọkacha arụmọrụ maka nje na-akpata nje, dịka etinyere ya n’usoro
• Ude bụ ụdị dị mma itinye.

Cons:

• Ojiji a na-eji suppositories adịghị adabara onye ọ bụla
• Odighi na mpempe mbadamba.

Clindamycin

Nizhpharm (Serbia)
Ọnụahịa - site na 167 r

Ihe nọ n'ọrụ bụ otu kemịkal kemịkalụ. Ọ dị n'ụdị capsule.

Uru:

• Formdị usoro onodu ogwu (capsules) adaba iji ya.
• Ọnụahịa ahụ dị ala.

Cons:

• Contraindicated na ime
• Otu mmetụta ahụ dị ka Dalacin C.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, ndị okenye: 150 mg kwa elekere 6 ọ bụla, na nnukwu ọrịa, enwere ike ịbawanye otu ọgwụ gaa na 300-450 mg ọgwụ. :Mụaka: 8-25 mg / kg / ụbọchị (ọ dabere na ogo ọrịa ahụ), kewara n'ime usoro 3-4.

Na ọgwụgwọ colpitis nke Chlamydia trachomatis kpatara, a na-enye ọgwụ mgmịnịsta 450 mg ugboro anọ kwa ụbọchị maka ụbọchị 10-14.

N'ime / m ma ọ bụ na / n'ime: ndị okenye - 300 mg 2 ugboro n'ụbọchị. Maka ọrịa na-adịghị ala ala - 150-300 mg 2-4 ugboro n'ụbọchị, maka ọrịa dị egwu - 1.2-2.7 g / ụbọchị maka injections 2-4. Site na ọrịa na-egbu ndụ, enwere ike ịba ụba iv ruo 4.8 g / ụbọchị.

Edebere ụmụaka 10-40 mg nke ọgwụ / n'arọ / ụbọchị, kewara n'ime usoro 3-4.

Maka nlekọta iv, dilute na mkpokọta na-adịghị elu karịa 6 mg / ml, a na-eme ka mmiri diluted iv na ntapu maka nkeji 10-60.

Usoro iheomume na oge nke infusion: dose, olu nke ihe mgbaze na oge nke infusion (n’otu n’otu): 300 mg - 50 ml - 10 min, 600 mg - 100 ml - 20 min, 900 mg - 150 ml - 30 min, 1200 mg - 200 ml - Nkeji 45 Ntughari ihe kariri 1.2 g n'oge 1 hour nke infusion akwadoro.

A na-eji ihe ngwọta ahụ eme ihe n'ime awa 24 site na ụbọchị nkwadebe. Na ọgwụgwọ nke colitis mere Clostridium difficile, nchịkwa jikọtara ya na vancomycin ozugbo maka ụbọchị 10 na 500 mg - 2 g kwa ụbọchị, kewara n'ime 3 ma ọ bụ 4 doses hà.

Ndị ọrịa nwere nnukwu akụrụ / ọrịa ịba ọcha n'anya na-achọ nhazi nke dose.

Omume ọgwụ

Ọgwụ nje nke ndị otu linkosamides. Ọ nwere ụdị ọrụ dị iche iche, bacteriostatic, na-ejikọ aka na 50S nke ribosomal akpụkpọ ahụ ma na-egbochi njikọ protein n'ime sel microbial. N'ikwekọ na ọtụtụ cocci gram-gram, mmetụta nje na-ekwe omume. Na-arụsi ọrụ ike megide Staphylococcus spp. (gụnyere penicillinase na-amịpụta staphylococcus epidermidis), Streptococcus spp. (ewezuga Enterococcus spp), Streptococcus pneumoniae, Corynebacterium diphtheriae, spore- na-abụghị spore na-etolite anaerobes, na microaerophilic gram-positive cocci (gụnyere Peptococcus spp. na Peptostreptococcus spp.), Clostridium perfringens, Clostridium perfringens, Clo Cloidi (gụnyere Bacteroides fragilis na Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp., Actinomyces spp.

Ọtụtụ ụdị Clostridium perfringens na-emetụta ọgwụ ahụ, mana, ebe ọ bụ na ụdị ọzọ nke clostridia (Clostridium sporogenes, Clostridium tertium) na-eguzogide ọgwụ, a na-atụ aro mkpebi mgbochi maka ọrịa ndị Clostridium spp kpatara.

Clinically adighi adighi agha megide Mycoplasma pneumoniae, influenne Haemophilus, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

Mgbochi nguzogide dị n’agbata Dalacin C na lincomycin. Ọ dị irè n'ịgwọ ọrịa asọmpomatic diphtheria (usoro ọgwụgwọ kwa izu, ọnụnụ).