Diabetalongzen, chọta, zụta

Aha ahia nkwadebe: Diabetalong

Mba nonproprietary aha: Gliclazide (Gliclazide)

Usoro onunu ogwu: Mbadamba ịtọhapụ

Arụ Ọrụ: Gliclazide (Gliclazide)

Otu na-ere ọgwụ: Ọrịa hypoglycemic maka nchịkwa ọnụ nke usoro sulfonylurea nke ọgbọ nke abụọ.

Ngwá ọgwụ ọgwụ:

Oral hypoglycemic ọgwụ, a na-enweta sulfonylurea nke ọgbọ nke abụọ.

Ọ na - akpali umeji insulin site na pancreas, na - agbada ọkwa nke glucose n'ọbara, na - eme ka mmetụta glucose dịkwuo elu ma na - eme ka ọ nwee mmetụta nke uru ahụ dị na insulin. Mgbe afọ 2 gasịrị ọgwụgwọ, ọtụtụ ndị ọrịa adịghị azụlite ọgwụ ahụ (ọnụọgụ insulin na postprandial insulin na nzuzo nke C-peptides ka dị).

Na-ebelata oge dị n'etiti oge iri nri rue mmalite insulin insulin. Ọ na - eweghachi mmiri ọgwụ insulin n'oge mbụ maka nzaghachi glucose (n'adịghị ka ihe ndị ọzọ sitere na sulfonylurea, nke nwere mmetụta tumadi n'oge ọkwa nke abụọ nke nzuzo). Ọ na - emekwa ka usoro nke abụọ nke insulin na - ebuwanye ibu. Na-ebelata ọnụ ọgụgụ kachasị elu nke hyperglycemia mgbe ị risịrị nri (belata postprandial hyperglycemia).

Glyclazide na - eme ka anụ ahụ dị n ’insulin dịkwuo ala mara mma (ya bụ, nwere mmetụta extrapancreatic). Na akwara anụ ahụ, mmetụta insulin na -akpali glucose, n'ihi mmetụta anụ ahụ nke insulin na-abawanye ụba (ruru + 35%), ebe ọ bụ na glycazide na-akpali ọrụ nke muscle glycogen synthetase.

Na -ebelata usoro glucose na imeju, na -eme ka ebumnuche glucose ọnụ na-ebu ọnụ.

Na mgbakwunye na emetụta metabolism metabolism, gliclazide na-eme ka microcirculation dịkwuo mma. Ọgwụ ahụ na-ebelata ihe ize ndụ nke thrombosis nke obere arịa ọbara, na-emetụta usoro abụọ nwere ike itinye aka na mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na-eme ka platelet (beta-thromboglobulin, thromboxane B2), yana mweghachi nke fibrinolytic vaskụla endothelial ọrụ na ụba ọrụ nke plasminogen anụ ahụ.

Glyclazide nwere ihe ndị na-egbochi antioxidant: ọ na-ebelata ọkwa nke peroxides lipid na plasma, na-abawanye ọrụ nke sel ọbara ọbara superoxide dismutase.

N'ihi njirimara nke usoro onunu ogwu, ubochi Diabetalong 30 mg mbadamba ọ bụla na-enye ọgwụgwọ ịgwọ ọrịa gliclazide dị mma na plasma ọbara ruo 24 awa.

Mgbe nchịkwa ọnụ gachara, a na-etinye gliclazide kpamkpam na ngụgụ nri. Iri nri anaghị emetụta mmịpụta. Ntinye uche nke ihe aru oru n’ime plasma obara ji nke nta nke nta mee, rute oke ma rute plateau rue elekere isii tupu i takingụọ ọgwụ. Onweghi ike n’otu n’otu di ala. Mmekọrịta dị n'etiti dose na itinye uche nke ọgwụ na plasma ọbara bụ ihe kwụ chịm n'oge.

Nkesa na metabolism

Njikọ protein protein Plasma bụ ihe dịka 95%.

Ọ bụ metabolized na imeju na-abụkarị site na akụrụ. Ọ dịghị metabolites nọ n'ọrụ na plasma.

Cụpụ akụrụ site na akụrụ na-emekarị n'ụdị metabolites, ihe na-erughị 1% nke ọgwụ a apụbeghị.

T1 / 2 bụ ihe dịka awa iri na isii (awa iri na abụọ ruo iri abụọ).

Pharmacokinetics n'ihe gbasara ọrịa

N'ime ndị agadi, enweghị mgbanwe pụtara ìhè dị na pọọmọnkinetic ọgwụ.

Ihe ngosi maka ojiji:

- elldị ọrịa shuga abụọ nke ọrịa mellitus na usoro ọgwụgwọ nri na nri na mmega ahụ ezughi oke.

Contraindications:

- ụdị shuga 1

- mamịrị ketoacidosis, ọrịa mamịrị, ụkwara ume ọkụ,

Na nnukwu akwara

- afọ ruo afọ 18

- oge ị breastụ nwa (na-enye nwa ara),

- ihe ọmụmụ nke lactose anabataghị, ụkọ lactase ma ọ bụ ọrịa glucose-galactose malabsorption,

- Hypersensitivity na gliclazide ma ọ bụ ihe ọ bụla nke ọgwụ ọgwụ, gaa n'ụkpụrụ ndị ọzọ nke sulfonylurea, na sulfonamides.

A naghị akwado ya ka ị useụ ọgwụ ahụ n'otu oge yana yana phenylbutazone ma ọ bụ danazole.

Iji nlezianya: ịka nká, enweghị usoro na / ma ọ bụ ihe oriri na-edozi ahụ, ọrịa siri ike nke usoro obi (gụnyere ọrịa obi na akwara, atherosclerosis), hypothyroidism, adrenal or pituitary insufficiency, hypopituitarism, akụrụ na / ma ọ bụ imeju, ọgwụgwọ ogologo oge na corticosteroids, egbu egbu, glucose-6-phosphate dehydrogenase.

Ime na lactation

Enweghị ahụmịhe na gliclazide n'oge afọ ime. Ihe omuma banyere ojiji nke ihe ndi ozo nke sulfonylurea n’oge di ime.

N'ime ihe omumu banyere umu anumanu, achoputala ihe omuma di nke gliclazide.

Iji belata ihe egwu nke ọrịa metụtara ọrịa metụtara ọrịa, ọ dị mkpa ijikwa ezigbo (ọgwụgwọ kwesịrị ekwesị) nke ọrịa shuga mellitus.

Anaghị eji ọgwụ hypoglycemic ọgwụ n'oge ime. Ọgwụ ịhọrọ maka ịgwọ ọrịa shuga n'ime ụmụ nwanyị dị ime bụ insulin. A na-atụ aro ka iji ọgwụ inspoglycemic nke na-aralụ ọgwụ jiri ọgwụ insulin dochie ya ma n'oge ime atụgharịrị, ma ọ bụrụ na ime mere mgbe ị na-a theụ ọgwụ ahụ.

N'iburu n'uche enweghị data na ị gụ gliclazide na mmiri ara ara yana ihe ọghọm nke ịmalite hypoglycemia nke afọ, a na-enye ụmụ ara ara n'oge ọgwụ.

Jiri maka ọrụ imeju na-arụ ọrụ

Na-akpachara anya na imeju ọdịda.

- nnukwu akwara na / ma ọ bụ imeju afọ.

Jiri maka ọrụ ezighi ezi na-arụ ọrụ

N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ruo na nke dị ala, a na-ede ọgwụ ahụ n'otu usoro ahụ dịka ndị ọrịa nwere ọrụ gbasara ọrụ nkịtị. Na nnukwu akwara okpu, Diabetalong bụ contraindicated.

Jiri na umuaka

Contraindicated n'ime ụmụaka na-erubeghị afọ 18.

Jiri ndị ọrịa agadi

Maka ndị ọrịa na-enwetabeghị ọgwụgwọ (gụnyere maka ndị okenye karịa afọ 65), ọgwụ mbụ bụ 30 mg. Mgbe ahinyere dose ahụ n’otu n’otu rue mgbe ikewapụtara ọgwụgwọ ọgwụgwọ chọrọ.

Mmekọrịta na ọgwụ ndị ọzọ:

Glyclazide na-akwalite nsonaazụ anticoagulants (warfarin); enwere ike ịchọ ndozi nke ọgwụ ahụ anticoagulant.

Miconazole (ya na usoro nchịkwa na mgbe ị na-eji gel na mucosa oral) na-eme ka mmetụta hypoglycemic nke ọgwụ ahụ dị elu (hypoglycemia nwere ike ịmalite ruo na coma).

Phenylbutazone (usoro nchịkwa) na-eme ka mmetụta hypoglycemic nke ọgwụ ahụ pụta (na-apụ n'ihi protein nke plasma na / ma ọ bụ na-akwụsịlata ahụ), njikwa glucose ọbara na mmezi nke glyclazide dị mkpa, ma n'oge nchịkwa phenylbutazone na mgbe ọpụpụ ya.

Ọgwụ ethanol nwere ọgwụ ethanol na-akwalite hypoglycemia, na-egbochi mmeghachi ụgwọ nkwụghachi ụgwọ, nwere ike inye aka na mmepe nke hypoglycemic coma.

Ka ị na-a withụ ọgwụ ọgwụ hypoglycemic ndị ọzọ (insulin, acarbose, biguanides), beta-blockers, fluconazole, AC inhibitors (captopril, enalapril), ndị na-anabata ọgwụ mgbochi H2 (cimetidine), MAO inhibitors, hypoglycemic na sulfanilamides na akara ihe egwu nke hypoglycemia.

N'iji ihe eji eme ihe na iji Danazol, choputara ihe oria mamiri. Ọ dị mkpa ịchịkwa ọkwa nke glucose ọbara ma mezie ọnụọgụ nke gliclazide, ma n'oge nchịkwa danazol na mgbe ọpụpụ ya.

Chlorpromazine na ọnụọgụ dị elu (karịa 100 mg / ụbọchị) na-abawanye ọdịnaya glucose na ọbara, na-ebelata ihe nzuzo nke insulin. Ọ dị mkpa ijikwa glucose ọbara ma dozie dose nke gliclazide, n'oge nlekọta nke chlorpromazine na mgbe ọpụpụ ya.

GCS (usoro, intraarticular, mpụga, nchịkwa rectal) na-abawanye glucose ọbara na mmepe nke ketoacidosis nwere ike (ibelata ntachi obi na carbohydrates). Ọ dị mkpa ijikwa glucose ọbara ma dozie dose nke gliclazide ma n'oge nchịkwa GCS na mgbe ha kwụsịrị.

Ritodrine, salbutamol, terbutaline (iv) na-abawanye glucose ọbara. A na-atụ aro nchịkwa glucose ọbara ma, ọ bụrụ na ọ dị mkpa, nyefee onye ọrịa na ọgwụgwọ insulin.

Usoro usoro onunu ogwu

Ezubere ọgwụ a maka ọgwụgwọ ndị okenye.

Mpempe akwụkwọ nke Diabetalong nke na-agbazi 30 mg na -eche ya ọnụ 1 oge / ụbọchị n'oge nri ụtụtụ.

Maka ndị ọrịa na-enwetabeghị ọgwụgwọ (gụnyere maka ndị okenye karịa afọ 65), ọgwụ mbụ bụ 30 mg. Mgbe ahinyere dose ahụ n’otu n’otu rue mgbe ikewapụtara ọgwụgwọ ọgwụgwọ chọrọ.

A ga-eme nhọrọ nhọrọ ya dabere na ogo nke glucose dị n'ọbara mgbe mmalite ọgwụgwọ. Enwere ike ịgbanwe mgbanwe ọ bụla na - esote izu ma ọ dịkarịa ala izu abụọ.

Theụ ọgwụ kwa ụbọchị nwere ike ịdị iche site na mg mg 30 (1 tab.) Ruo 90-120 mg (3-4 tab.). Dosebọchị kwa ụbọchị ekwesịghị ịkarị 120 mg (4 mbadamba).

Diabetalong nwere ike dochie mbadamba gliclazide mbido (80 mg) na mbadamba 1 ruo 4 / ụbọchị.

Ọ bụrụ n’otu ọgwụ ị oneụ otu ọgwụ ma ọ bụ karịa ga-efu gị, ịnweghị ike ị aụ ọgwụ dị elu na usoro ọzọ (na-esote ụbọchị).

Mgbe dochie ọgwụ hypoglycemic ọzọ na mbadamba Diabetalong® 30 mg, ọ nweghị oge mgbanwe. Must ga-ebu ụzọ kwụsị ị theụ ọgwụ kwa ụbọchị na naanị ụbọchị na-esote ịmalite ị startụ ọgwụ a.

Ọ bụrụ na onye ọrịa ahụ anatala ọgwụgwọ na sulfonylureas na ọkara ndụ ogologo, mgbe ahụ nlezianya nlezianya (nyochaa nke glucose ọbara) maka izu 1-2 dị mkpa iji zere hypoglycemia n'ihi nsonaazụ nsonaazụ nke usoro ọgwụgwọ gara aga.

Enwere ike iji Diabetalong jikọta ya na biguanides, alpha glucosidase inhibitors ma ọ bụ insulin.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ruo na nke dị ala, a na-ede ọgwụ ahụ n'otu usoro ahụ dịka ndị ọrịa nwere ọrụ gbasara ọrụ nkịtị. Na nnukwu akwara okpu, Diabetalong bụ contraindicated.

N'ime ndị ọrịa n'ihe ize ndụ nke ịmalite hypoglycemia (nri na-ezughị ezu ma ọ bụ nke na-adịghị edozi ahụ, nkwarụ endocrine na-arịa ma ọ bụ na-adịghị mma - pituitary na adrenal insufficiency, hypothyroidism, kagbuo glucocorticosteroids mgbe ogologo oge na / ma ọ bụ nchịkwa dị elu, ọrịa siri ike nke usoro obi. ajọ ọrịa obi, akwara carotid arteriosclerosis, atherosclerosis /) na-atụ aro ka iji obere opekata mpe (30 mg 1 oge / ụbọchị) nke ọgwụ Diabetalong.

Ntụziaka pụrụ iche:

A na-eme ọgwụgwọ naanị na jikọtara obere kalori, nri nwere obere carb.

Ọ dị mkpa ịdị na-enyocha ọkwa glucose mgbe niile n'ọbara na afọ na-enweghị nri na mgbe erichara nri, ọkachasị na ụbọchị mbụ ọgwụgwọ ọgwụ.

Enwere ike ịnye Diabetalong naanị ndị ọrịa na-anata nri mgbe niile, nke bụcha isi na-agụnye nri ụtụtụ ma na-enye ezigbo carbohydrates.

Mgbe ị na-edepụta ọgwụ ahụ, ekwesịrị iburu n'uche na n'ihi nnweta nke ikike dị iche iche nke sulfonylurea, hypoglycemia nwere ike ịmalite, na n'ọnọdụ ụfọdụ n'ụdị siri ike ma dịte aka, chọrọ ụlọ ọgwụ na nchịkwa glucose ruo ọtụtụ ụbọchị. Hypoglycemia na-etolitekarị nri nwere kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị alcoholụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge.

Iji zere mmepe nke hypoglycemia, a chọrọ nlezianya na nhọrọ nke usoro onunu ogwu, yana inye onye ọrịa ozi zuru ezu gbasara ọgwụgwọ a tụrụ aro.

Site na oke mmega ahụ na nke mmetụta uche, mgbe ị na-agbanwe nri, ịhazigharị ọgwụ nke Diabetalong dị mkpa.

Kachasị emetụta ọrụ nke hypoglycemic ọgwụ bụ ndị agadi, ndị ọrịa na-adịghị enweta a nri edozi, na a n'ozuzu ike gwụrụ ala, ndị ọrịa na-enwe pituitary-adrenal ezughi oke.

Beta-blockers, clonidine, reserpine, guanethidine nwere ike kpuchie ngosipụta nke hypoglycemia.

E kwesiri ịdọ ndị ọrịa aka na ntị gbasara ike ịba ụba hypoglycemia n'ọnọdụ ethanol, NSAIDs, na agụụ.

N'ihe banyere ethanol (mmanya), ọ ga-ekwe omume ịmalite ọrịa disulfiram dịka ọrịa afọ, mgbu, ọgbụgbọ, ọgbụgbọ, isi ọwụwa.

Nnukwu ihe ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile nwere ike ịchọ nkwụsị nke ọgwụ hypoglycemic nke ọnụ na ịhọpụta ọgwụgwọ insulin.

Mmepe nke iguzogide ọgwụ nke abụọ ga - ekwe omume (a ghaghị ịpụ iche na nke mbụ, nke ọgwụ a anaghị enye nsonaazụ a na-atụ anya na nnọkọ mbụ).

Na-emegide usoro ọgwụgwọ nke ọgwụ Diabetalong, onye ọrịa ahụ ga-ahapụ ị ofụ mmanya na / ma ọ bụ ọgwụ ethanol nwere ọgwụ na nri nri.

N'oge ọgwụgwọ na Diabetalong, onye ọrịa ahụ ga-ekpebi ọkwa nke glucose na glycosylated haemoglobin n'ọbara, yana ọdịnaya glucose dị na mmamịrị.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mmụba nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mmetụta ọghọm:

Hypoglycemia (nke mebiri usoro ịsingụ ọgwụ na nri na-ezighi ezi): isi ọwụwa, ike ọgwụgwụ, agụụ, ịba ụba, nrịanrịa, palpitations, arrhythmia, ọbara mgbali elu, iro ụra, nsogbu ehighị ụra, oke iwe, oke iwe, nchekasị, oke iwe, nlebara anya enweghị ike, enweghị ike. mgbado anya na mmeghari oge, ịda mba, ọhụhụ anya, aphasia, shoor, paresis, ọgba aghara sensor, ọgbụgba, mmetụta nke enweghị enyemaka, ọnwụ nke njide onwe onye, ​​enweghị nchekasị, nkwarụ, enweghị atụ. e respiration, bradycardia, amagh onwe, amaghị onwe ya.

Site na usoro nri: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, mgbu nke afọ, afọ ntachi (ogo ihe mgbaàmà ndị a na-ebelata mgbe ewere ya na nri), adịkarịghị - ọrụ imeju na-arụ ọrụ (ịba ọcha n'anya, ịba ụba nke ọrịa hepatic, alkaline phosphatase, cholestatic jaundice - chọrọ iwepụ ọgwụ).

Site na akụkụ ahụ haemopoietic: mgbochi nke ụmị ọkpụkpụ (anaemia, thrombocytopenia, leukopenia, granulocytopenia).

Mmeghachi omume nfụkasị: ọnya akpụkpọ, urticaria, ọnya anụ ahụ gụnyere maculopapular na okwu ojoo), erythema.

Ndị ọzọ: enweghi ike ịhụ ụzọ.

Nsonaazụ ndị ọzọ a na-ahụkarị na njikọta sulfonylurea: erythropenia, agranulocytosis, hemolytic anaemia, pancytopenia, vasculitis nfụkasị, ọrịa imeju na-egbu ndụ.

Dodoụbiga ya ókè

Mgbaàmà: hypoglycemia, nsụhọ nke uche, hypoglycemic coma.

Ọgwụgwọ: ọ bụrụ na onye ọrịa maara, were shuga n’ime.

Ikekwe mmepe nke ọnọdụ hypoglycemic siri ike, tinyere coma, nkwarụ ma ọ bụ nsogbu akwara ndị ọzọ. Ọ bụrụ na ụdị mgbaàmà ndị ahụ apụta, nlekọta ahụike mberede na ụlọ ọgwụ ozugbo ọ dị mkpa.

Ọ bụrụ na enyo enyo na hypoglycemic coma na-enyo enyo ma ọ bụ chọpụta ọrịa, a na-awụnye onye ọrịa ngwa ngwa site na 50 ml nke 40% dextrose (glucose). Mgbe ahụ, a ga - etinye ntụtụ 5% dextrose (glucose) na-agba ọbara n'ime ọbara iji nọgide na-enwe ọkwa glucose dị n'ọbara.

Mgbe mweghachi nke nsụhọ, ọ dị mkpa inye nri onye ọrịa nri n'ụba n'ụdị carbohydrates dị mfe ọrịa (iji zere ịmalite mmepe nke hypoglycemia). Ekwesịrị iji nlezianya nyochaa ọkwa glucose ọbara na nyochaa onye ọrịa ahụ ma ọ dịkarịa ala awa 48 na-esote. Mgbe oge a gasị, dabere n'ọnọdụ onye ọrịa, dibịa na-aga na-ekpebi mkpa ọ dị inyochakwu ya.

Nchọpụta adịghị arụ ọrụ n'ihi nkwupụta akpọrọ nke gliclazide na protein protein.

Bọchị mmebi: Afọ 3

Ọnọdụ nke izipu ọgwụ site na ụlọ ahịa ọgwụ: Site na ndenye ọgwụ.

Emeputa: SYNTHESIS, OJSC (Russia)