Mbadamba Hypoglycemic Glybomet: ntuziaka maka ojiji

A na-emepụta ọgwụ hypoglycemic n'ụdị dragees nke ndo dị ọcha. Mbadamba ụyọkọ Glibomet ọ bụla nwere metformin hydrochloride na glibenclamide, bụ ndị na-arụ ọrụ dịka ihe ndị nọ n'ọrụ. Ihe inyeaka bụ gelatin, MCC, ụdị silica, mkpụrụ osisi ọka, magnesium stearate, glycerin, diethyl phthalate, cellulose acetate phthalate na talc.

Iji Gara ọgwụ hypoglycemic Glybomet, ntuziaka maka iji ya enye ndụmọdụ naanị ma ọ bụrụ na monotherapy na ọgwụ ọnụ ma ọ bụ ọgwụgwọ nri adịghị arụ ọrụ maka ọgwụgwọ nke ụdị ọrịa shuga na-abụghị insulin 2 nke ọrịa mellitus. Na mgbakwunye, onye nrụpụta na-atụ aro ka edetu mbadamba ihe ndị a na ibelata ntaramahụhụ nke sulfonylureas n'ihi ojiji ha ogologo oge.

Banyere mmeghachi omume na-adịghị mma na nsonaazụ ndị ọ ga-ekwe omume, ịpụta nke a na-ebutekarị site na ị iburu mbadamba Glybomet, ihe ize ndụ nke hypoglycemia, cholestatic jaundice ma ọ bụ ịba ọcha n'anya kwesịrị ibupụta ebe a. Na mgbakwunye, ụfọdụ ndị na-eji ngwá ọrụ a nwere ike ịnwe ọnọdụ dịka ọgbụgbọ, isi ọwụwa, adịghị ike, nsogbu ọgba aghara, hives, paresis, nkwonkwo akwara, megaloblastic or hemolytic anemia, mgbu nkwonkwo.

Glybomet - ihe mejupụtara

Nchikota na mbadamba ihe obula nke ihe abuo na aru oru - metformin hydrochloride (400 mg) na glibenclamide (2.5 mg) na - eme ka o kwe omume obughi ichikota glycemia, kamakwa iji belata ogwu nke ihe ndia. Ọ bụrụ na ejiri ha otu maka ọgwụgwọ monotherapy, usoro ọgwụgwọ ahụ ga-adị elu nke ukwuu.

O nwere usoro na nke ochie n'ụdị cellulose, ọka ọka, colloidal silicon dioxide, gelatin, glycerin, talc, magnesium stearate, acetylphthalyl cellulose, celethlose diethyl.

Njirimara nke ogwu

Otu n'ime ihe ndị bụ isi na-arụ ọrụ, glibenclamide, bụ ọgwụ nke klaasị sulfonylurea ọgbọ ọhụrụ, nke a gụnyere na ndepụta nke ọgwụ ndị dị mkpa na ikike puru iche.

Ọ bụghị naanị na-akpali ọrụ nke pancreas n'ozuzu ya, kamakwa ọ na-eme ka insulin nke ọgwụ endogenous dịkwuo mma. Usoro nke ọrụ ha sitere na nchekwa nke mkpụrụ ndụ panc-pancreatic by-mebiri site na glucose na-eme ihe ike, bụ nke na-ekpebi uto nke ọrịa shuga, na mkpali nke inwe mmetụta insulin nke mkpụrụ ndụ ndị chọrọ.

Iburu Glibomet na myirịta glycemic na-eme ka metabolism dị nwayọ ma belata ihe ọghọm nke ọbara ọgbụgba. Ọrụ nke insulin na-abawanye, yana ya nnabata nke glucose site na anụ ahụ akwara na imeju. Ọgwụ na-arụ ọrụ na ọkwa nke abụọ nke mmepụta insulin.

Metformin bụ nke biguanides - klaasị nke ihe ndị na - akpali akpali nke na - eme ka mkpụrụ ndụ sel kpuchie ìsì na insulin nke ha. Maliteghachi ịmata ihe adịghị mkpa karịa ịkwalite secretion nke homonụ, n'ihi na n'ụdị ọrịa shuga 2, pancreas na-amịpụta ya karịa.

Metformin na - eme ka kọntaktị ndị na - anabata ya na insulin dịkwuo elu, na - eme ka homonụ na - ebute postreceptor. Na enweghị insulin n'ime n'ọbara, a naghị egosipụta mmetụta ọgwụgwọ.

Metformin nwere atụmatụ pụrụ iche:

Ọ na-eji nwayọ nwayọ na -akpata ịmịkọta glucose ma na-enyere aka itinye ya na akwara,
Na-egbochi gluconeogenesis,
Na-echebe b-cell ahụ site na ngwa ngwa apoptosis.
Na-ebelata ihe ize ndụ nke ụdị acidosis na ọrịa ọ bụla siri ike,
Ọ na - eme ka microcirculation nke mmiri mmiri, ọrụ endothelial na metabolism nke abụba (na - eme ka ị nweta cholesterol na "triglycerol" na - emerụ ahụ).
Na-eme ka ịbelata oke - ọnọdụ dị mkpa maka njikwa glycemic dị mma na ụdị 2 DS,
Na-ebelata njupụta ọbara na nrụgide oxidative,
Ọ nwere mmetụta nke fibrinolytic site na igbochi plasminogen anụ ahụ,
Ọ na - egbochi usoro oncological (n'ozuzu, ọrịa shuga na - eme ka ihe oncology dịkwuo elu site na 40%),
Na-ebelata ihe ize ndụ nke ọnwụ site na akụrụngwa obi.

Nnyocha nyocha nke ndị ọrịa mamịrị 5800 nwere ụdị shuga 2 na China. Ndị sonyere na nnwale ahụ natara metformin yana mgbanwe usoro ndụ. N'ime ndị na-achịkwa, ndị ọrụ afọ ofufo gbanwere ụzọ ndụ ha. N'ime ọnwa 63, na ìgwè nke mbụ, ọnwụ bụ mmadụ 7.5 n'ime 1000 mmadụ / afọ, na nke abụọ - ọnwa iri anọ na ise, dịkarịa ala, mmadụ 11.

Ọgwụ malitere ịrụ ọrụ awa abụọ mgbe ọ banyechara esorogus, arụpụtara arụmọrụ ya kemgbe awa iri na abụọ. Metformin anaghị ebute iyi egwu hypoglycemic. Ọgwụ nke nwere nnukwu ihe akaebe, agafeela ule siri ike nke oge ma chọọ ọrịa shuga n’oge niile ịba ụba nke ọgwụgwọ.

Taa, ahịa ọgwụ na-enye klaasị nke ọgwụ antidiabetic 10, mana metformin ka bụ ọgwụ kachasị ewu ewu maka ịgwọ ụdị ọrịa shuga 2 na ọkwa ọ bụla.

Ngwakọta njikọta nke ihe abụọ na-arụ ọrụ nke Glibomet nwere mmetụta siri ike n'ahụ.

Mmetụta ọrịa ụjọ - ọgwụ a na - ebelata “ìsì” nke mkpụrụ ndụ, na - akpali insulin nke ya, ma na - edozi sel b.
Mmetụta na-eme ka anakpo- pancreatic - biagudin na-emetụta akwara na anụ ahụ na-egbu egbu, na-ebelata gluconeogenesis, na-eme ka pasent zuru oke na-ebuli glucose.

Ezigbo oke nke oke nke ihe ndị na-arụ ọrụ nwere ike ịhazigharị usoro ọgwụ. Maka mkpụrụ ndụ b, ihe mkpali dị otú a dị ezigbo mkpa: ọ na-eme ka nchekwa nke ọgwụ dịkwuo ike, na-ebelata ọghọm nke arụ ọrụ, ma na-ebelata ohere nke nsonaazụ.

Ike nke Pharmacokinetic

A na-ahụta Glybenclamide site na eriri afọ ma na-ekesa ya nke ọma - site na 84%, enwere ike ịhụ mmetụta kachasị ukwuu nke ọgwụ ahụ mgbe awa 1-2 gachara. Ihe mejuputara ihe ndi ahu na aru oru ọbara n’ime 97%.

Metabolism nke Glibenclamide na-apụta na imeju, ebe a gbanwere kpamkpam ka ọ bụrụ metabolites na-adịghị arụ ọrụ. Ọkara nke ihe emefuola na-aga akụrụ, ọkara nke ọzọ gafere site na ebe ihe na-egbu egbu. Ọkara ọkara bụ ọkara awa 10.

Metformin na-abanye kpamkpam na usoro nri, na-ekesa ozugbo na akụkụ ahụ yana anụ ahụ, ọ naghị agbanye protein protein. Bioavailability nke ihe mejupụtara ya sitere na 50-60%.

Na mkpokọta, nsị nke kacha mejupụta usoro mmiri dị n'ime ọbara pụtara otu elekere ma ọ bụ abụọ mgbe ị takingụ ọgwụ ahụ.

Ihe ngosi maka ọgwụgwọ na Glybomet

Ntụziaka gọọmentị na-egosi na enyere ọgwụ a maka ọrịa shuga 2, gụnyere ndị ọrịa shuga na-adabere, ma ọ bụrụ na nri pụrụ iche, mmega ahụ arụ ọrụ yana ọgwụ hypoglycemic ọzọ enyeghị nsonaazụ ahụ ezubere.

Ọtụtụ ọgwụ nwere mmetụta na-eri ahụ, ọ bụrụ na anụ ahụ anaghị anabata ọgwụgwọ ọfụma, ha na-agbanwe algorithm ọgwụgwọ site na idepụta Glibomet na mbadamba.

Whomnye ka ọgwụ e nyere si dị ire?

Ebe ọgwụ ahụ nwere mmetụta dị mgbagwoju anya na nsogbu ahụ, ọ bụghị ihe ijuanya na o nwere oke mgbochi na mbanye.

Ọgwụ nwere ike ịdị ize ndụ:

Ọrịa afọ ime,
Ọ bụrụ na onye ọrịa nwere uche dị ukwuu n'ihe banyere usoro ahụ,
Ndị ọrịa shuga na ụdị ọrịa mbụ,
Na ọrịa shuga na ọnọdụ akara, Kedu ka ị ga-esi Glibomet

Enwere ikike mgbochi iwere Glibomet:

Na ọrịa nke thyroid gland,
Ọ bụrụ na ọrịa nwere ahụ ọkụ,
Mgbe akụkọ banyere hypofunction nke pituitary cortex na adrenal gland.

A na-ekpebi usoro ọgwụgwọ ahụ site na endocrinologist dabere na afọ onye ọrịa na atụmatụ ụlọ ọgwụ, mana onye nrụpụta na-atụ aro ịmalite site na mbadamba mbadamba abụọ kwa ụbọchị, na-ejide ọgwụ ahụ mgbe niile. Ogo ọgwụ kachasị bụ 2 g / ụbọchị. Ọ dị mma ikesa oriri a n'oge oge. Ọ bụrụ na ego a enweghị mmetụta a tụrụ anya ya, a na-enye usoro ọgwụgwọ siri ike na mgbakwunye nke ọgwụ siri ike.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Enwere ọtụtụ nsonaazụ na-adịghị mma nke nwere ike ime mgbe ị nwusịrị Glibomet, mana nke a ekwesịghị ịbụ ihe kpatara ịjụ ọgwụ, n'ihi na mmerụ ahụ na-akpatara ahụ mmadụ ọrịa shuga na-enweghị oke dị elu karịa ihe egwu nke mmetụta ndị ọzọ.

Iji zere ọnọdụ ndị dị otú a, ọ dị mkpa ịkọwa usoro ị kwesịrị ịgụta. Ọ bụrụ na iwu karịrị akarị, ndị na-arịa ọrịa shuga na-akpọte agụụ na-enweghị isi, ike na-agwụ ike, ụjọ, aka na-ama jijiji.

Mgbaàmà nke ịdoụbiga ihe ókè nwekwara ike ịbụ tachycardia, ịchacha akpụkpọ ahụ, ịsụsọ nke ukwuu, ịda mba.

N'ime nsogbu ndị kachasị njọ mgbe ị nwesịrị Glibomed, hypoglycemia bụ ihe kachasị dị ize ndụ n'ọnọdụ a maka ndị ọrịa na-arịa ọrịa ogologo oge, ndị ọrịa shuga nke afọ toro ogologo na-arịa ọrịa shuga, ndị a alcoụrụma, ndị mmadụ na-arụ ọrụ ike, yana onye ọ bụla na-anọdụ ọkara agụụ. erughị 1000 kcal / ụbọchị.) nri.

N’ime akara ngosiputa, ihe ndi ozo bu:

Isi ọwụwa
Mgbakasị epigastric,
Ọrịa Dyspeptik
Dị mmeghachi omume nfụkasị dị iche iche.

Ọ bụrụ na ahụ erughị ala nwa oge na-ewere mbadamba mbadamba, enwere ike wepu ya site na ọgwụgwọ Symptomatic. Ọ bụrụ na mgbaàmà siri ike ma ọ bụ ihe ịrịba ama nke nfụkasị gosipụtara, mgbe ahụ ị ga - ahọrọ analogues maka Glibomet.

Nsonaazụ Njikọ Ọgwụ

A na-ahụta mmụba na hypoglycemic mmetụta nke Glybomet n'oge ọgwụgwọ ihe yiri ya na usoro nke decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone na usoro dị ukwuu, probenecid, chloramphenicol, the main ọgwụ, microon, nje .

Usoro ọgwụgwọ a na-ejikọ ya na homonụ nke gland thyroid, mgbochi ogwu a na-ede ede, barbiturates, ọgwụ thiazide diuretic na-egbochi ike nke Glibomet.

Ntụziaka pụrụ iche

A na-akwụsị iji Glibomet ozugbo mgbe enwere ihe ịrịba ama nke lactic acidosis: adịghị ike siri ike, ọgbụgbọ, spasm muscle, mgbu n'ime oghere afọ. Onye a tara ahụhụ chọrọ ụlọ ọgwụ ngwa ngwa.

Ntụziaka ahụ na-atụ aro ọgwụgwọ na Glybomet iji soro na nlekota nke creatinine na nyocha ọbara. Maka ndị ọrịa mamịrị nwere akụrụ siri ike, inyocha ụdị nyocha a dịkarịa ala otu ugboro n'afọ, ndị ọrịa nke ọkwa creatinine dị nso na oke nke ụkpụrụ, a ga-anwale ndị ọrịa tozuru eto 2-4 ugboro n'afọ.

Daysbọchị abụọ tupu usoro ịwa ahụ emepụtara, nke iji ọgwụ mgbochi azụ ma ọ bụ ọgwụ epidural, ewere Glibomet na-akagbu, ọ na-agbanye insulin na insulin.. Can nwere ike weghachite usoro ọgwụgwọ na Glybomet mgbe ahapụchara onye ọrịa ka ọ rie nri. N'agbanyeghị na akụrụ na-arụkarị ọrụ, dọkịta na-eme mkpebi a tupu ụbọchị abụọ ka ọrụ ahụ gasịrị.

Illsnweta ọgwụ chọrọ ịkpachara anya mgbe ị na-arụ ọrụ nwere ike ibute ndụ na ahụike, yana mgbe ị na-anya ụgbọala. Ejikọtara nke a na ọrịa hypoglycemia, mbelata ọnụego mmeghachi omume psychomotor na ikike itinye uche.

Nsonaazụ ọgwụgwọ Glibomet ga-agbakwasị ụkwụ na izi ezi nke ịgbaso ndụmọdụ ndị etinyere na ntuziaka na ntuziaka nke endocrinologist: ịgbaso usoro nri na usoro ụra na izu ike, mmega ahụ mgbe niile, njikwa glycemic usoro, gụnyere n'ụlọ.

Mgbe ị na-a theụ ọgwụ, ọ dị mkpa amachibido iji ihe ọ ofụ alcoholụ na-aba n'anya mee ihe ọ bụla o kwere omume (ụkpụrụ ahụ bụ iko mmanya na-acha ọbara ọbara na-acha ọbara ọbara otu ugboro n'izu), ebe ethanol na-akpalite mmepe nke glycemia, yana nkwarụ disulfiram - mgbu na mpaghara epigastric, ọgba aghara dyspeptik, ọkụ na-ekpo ọkụ na anụ ahụ dị elu na isi, mfu. nhazi, isi ọwụwa, palpitations.

Ọnụ ego ọgwụ na iwu nchekwa

Glybomet ọ nwere ike ị nweta ego na ụlọ ahịa ọgwụ? Dabere na mpaghara, enwere ike ịzụta ọgwụ ahụ maka 200-350 rubles. Otu ngwugwu ọ bụla nke Glibomet, foto nke enwere ike ịhụ na nkebi a, nwere mbadamba 40.
Ka ọgwụ a ghara ịhapụ ịdị irè ya, a ga-echekwa ya site na ìhè anyanwụ na ihu igwe dị elu.

Ọgwụ yiri ya

Ọ bụrụ na Glibomed ọbụlagodi na usoro ọgwụgwọ siri ike anaghị enye nsonaazụ achọrọ, nfụkasị ma ọ bụ mmetụta ndị ọzọ dị njọ apụtawo, a na-eji ọgwụ mmechi dochie ọgwụ analogues jiri ihe kwesịrị ekwesị n'ọrụ.

Maka Glibomed, ọgwụ ndị dị otú ahụ nwere ike ịbụ mbadamba Diabeton, ihe bụ isi na-arụ ọrụ nke bụ glyclazide, ma ọ bụ Dimaril, nke ogige ahụ nọ n'ọrụ bụ otu ihe mejupụtara Glibomed, glimepiride.

N'ime ọgwụ ọgwụ antidiabetic ndị ọzọ nwere mmetụta yiri ya, Gluconorm, Bagomet Plus, Glucovans, Glibenclamide na njikọta na Metformin, Glyukofast ka edepụtara.Endocrinologist na-eme onye ga-anọchi ya, ọ ga-agbakọọ usoro onunu ogwu. Mgbanwe na usoro ọgwụgwọ ga - ekwe omume: edepụtara analogues ma na ọgwụgwọ dị mgbagwoju anya ma n'ụdị monotherapy, dị ka mgbakwunye na nri nri carb na obere ahụ.

Ọ bụ 100% na-agaghị ekwe omume ịkọ ihe omume anụ ahụ ga-eme na ọgwụ ọhụrụ, yabụ, oge izizi dị mkpa toaa ntị na mgbaama a niile ma gwa dọkịta banyere mgbanwe gbanwere na mberede, oke ịba, Nsonaazụ nke nnwale glycemia na glucometer na ndị ọzọ dị mkpa n'oge oge iji megharia na usoro ọzọ.

Nyocha banyere njirimara nke Glibomet

Banyere ọgwụ Glycomet ọgwụ banyere ndị ọrịa shuga na-emetụta ihe algorithm nke iji ya karịa arụmọrụ.

Ọ bụrụ n ’ịhọrọ usoro ọgwụgwọ ọfụma, azịza ya bụ nke dị mma, mgbe ụfọdụ enwere ntụnye aka na obere nsonaazụ. Ma ebe ọ bụ na ngụkọ ndị a bụ nke onwe, dabere na ọmụmụ ụlọ ọgwụ na njirimara nke usoro ọrịa ahụ n'otu onye ọrịa, mgbanwe nke ahụmịhe na nke a abaghị uru, yana ruo n’ókè ụfọdụ.

N'ịchịkọta akụkọ niile, anyị nwere ike ikwubi na Glibomed bụ ọgwụ izizi maka ụdị ọrịa shuga 2 na-arịa: ego dị oke ọnụ, profaịlụ nchekwa dị elu, nnọpụiche n'ihe metụtara ogo ahụ, mmetụta bara uru na nsonaazụ obi na oncological.

N'ezie, ojiji ya agaghị ekwe omume maka mmadụ niile (dịka ọgwụ hypoglycemic ndị ọzọ), mana ọgwụ ahụ kwekọrọ n'ụkpụrụ nke ogo na mkpa ọgbara ọhụrụ.

Ọgwụ Farmacology

Nchikota nke onodu onu aru nke onu abuo nke ndi otu ogwu: glibenclamide na metformin.

Metformin bụ nke otu biguanides ma belata ọdịnaya nke ma basal na postprandial glucose na plasma ọbara. Metformin anaghị akpali insulin na ya mere ọ bute hypoglycemia.O nwere usoro ọrụ atọ: ọ na-ebelata mmepụta nke glucose site na imeju site na igbochi gluconeogenesis na glycogenolysis, na-eme ka nnabata nke ndị na-anabata insulin na-eme ka ọ ghara ịdị, ike na ojiji nke glucose site na mkpụrụ ndụ dị na akwara, na-egbu oge ịmịcha glucose na ngwangwa diges. Na-emezi ma ọ bụ belata oke ahụ n'ahụ ndị ọrịa nwere ọrịa shuga.

Ọ nwekwara mmetụta bara uru na ngwakọta nke ọbara, na-ebelata cholesterol zuru oke, LDL na triglycerides.

Metformin na glibenclamide nwere usoro ọrụ dị iche iche, mana jikọtara ọrụ hypoglycemic ọrụ ibe ha. Njikọ nke ndị na - arụ ọrụ hypoglycemic abụọ nwere mmetụta mmekọrịta na ibelata glucose.

Glibenclamide. Mgbe ejiri hazie, nnabata si eriri afọ bụ ihe karịrị 95%. T max - 4 awa, V d - ihe dị ka 10 lita. Nkwukọrịta na protein protein bụ 99%. Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju ya na imepụta metabolites abụọ na-adịghị arụ ọrụ, nke akụrụ na-ewepụta (40%) na site na eriri afọ (60%). T 1/2 - site na awa anọ ruo na iri na otu

Metformin mgbe nchịkwa ọnụ gasịrị, ọ na-ewepụtakwa ya na eriri afọ kpamkpam ezuola, C max na plasma erute na awa 2.5. Nkpuru osisi zuru oke sitere na 50 ruo 60%. Site na ntinye n'otu oge, nnabata nke metformin na-ebelata ma na-egbu oge. A na-ekesa Metformin ngwa ngwa na anụ ahụ, ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ bụ metadolized ruo obere adịghị ike ma kpụrụ ya akụrụ. Nwepu nke metformin n'ihe ọmụmụ dị mma bụ 400 ml / min, nke na-egosi ọnụnọ nke tubular nzuzo na-arụ ọrụ. Ihe dị ka 20-30% nke metformin bụ nke dị na eriri afọ na-agbanweghi. T 1/2 bụ nkezi nke awa 6.5. N'ọnọdụ ọrụ na-arụ ọrụ ezumike nkuku, ikike ịkpọkasị akwara na-ebelata, dịka nsachapụ nke creatinine, ebe T 1/2 na-abawanye, nke na-eduga n'ịba ụba na ịta plasma metformin. Metformin na glibenclamide dị na otu mbadamba nwere otu bioavailability dị na mbadamba nkume nwere metformin ma ọ bụ glibenclamide. Mmetụta bioavailability nke metformin yana yana glibenclamide anaghị emetụta nri oriri, yana bioavailability nke glibenclamide. Agbanyeghị, ogo oriri glibenclamide na-abawanye site na nri ị na-eri.

Ojiji ihe Glibenclamide + Metformin

Elldị shuga abụọ nke ọrịa mellitus na ndị okenye na-adịghị arụ ọrụ nke usoro ọgwụgwọ nri, mmega ahụ nkịtị na monotherapy gara aga na usoro metformin ma ọ bụ usoro sulfonylurea, nnọchi ọgwụgwọ gara aga na ọgwụ abụọ (usoro metformin na sulfonylurea) na ndị ọrịa nwere ọkwa glycemia kwụ chịm ma na-achịkwa nke ọma.

Ihe ngbanwe

Hypersensitivity na metformin, glibenclamide ma ọ bụ ihe ndị ọzọ na - eme ka sulfonylurea, ụdị shuga mellitus, mamịrị ketoacidosis, ọrịa shuga, ọrịa mamịrị, ọdịda akụrụ ma ọ bụ ọrụ ezumike ezi (creatinine Cl erughị 60 ml / min), ọnọdụ ọjọọ nke nwere ike ibute mgbanwe ọrụ. akụrụ: akpịrị ịkpọ nkụ, ọrịa dị egwu, ujo, nchịkwa intravascular nke ayodiin nwere ihe dị iche (lee anya "Nkpachara anya"), ọrịa ma ọ bụ ọrịa na-adịghị ala ala nke hypoxia na-eso. anụ ahụ: obi ma ọ bụ nke iku ume, mmebi myocardial infarction, ọrịa imeju, porphyria, ojiji nke miconazole, ọrịa na-efe efe, nnukwu ịwa ahụ, mmerụ ahụ, oke ọkụ na ọnọdụ ndị ọzọ chọrọ ọgwụ insulin, ịhoụbiga mmanya ókè, ị intoụbiga mmanya ókè, na-egbu egbu acid. gụnyere na anamnesis), ịgbaso nri kalori (erughi 1000 kcal / ụbọchị), afọ ime, oge inye ara, ụmụaka na-erubeghị afọ 18.

Ime na lactation

N'oge ime, eji contraindicated. E kwesịrị ịdọ onye ọrịa ọdụ na oge ọgwụgwọ yana ngwakọta nke glibenclamide + metformin, ọ dị mkpa ịgwa dọkịta banyere atụmatụ ịtụrụ ime na mmalite nke ịtụrụ ime. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n'ihe gbasara afọ ime n’oge ị theụ ọgwụ ike, ekwesịrị ịkagbu ya, na ọgwụ insulin.

A na-egbochi ya n'oge a na-enye nwa ara, ebe ọ nweghị data ọ bụla na ike nke mkpokọta glibenclamide + metformin ịbanye n'ime mmiri ara. Ọ bụrụ na ọ dị mkpa, iji oge ị breastụ ara kwesịrị ịtụgharị insulin ọgwụ ma ọ bụ kwụsị inye ara.

Metabolism na ntụpọ

Fọrọ nke nta ka metabolized n'ime imeju. Ọkara nke mbụ nke ihe ahụ na-apụta na mmamịrị, nke abụọ 50% na-apụta na bile. T1 / 2 - 3-16 elekere.

Ndopu na nkesa

Anọrọ site na ihe digestive tract jiri ihe ruru 50%. Ezigbo bioavailability bụ 50-60%. A na-ekesasị ya na anụ ahụ ozugbo, ihe fọrọ nke nta ka ọ bụrụ adịghị emetụta protein protein.

Metabolism na ntụpọ

Metabolism bụ ihe na-esighi ike, akụkụ ahụ ya na mmamịrị (ọ fọdụ n'ụdị mbụ ya) yana akụkụ ụfọdụ na feces. T1 / 2 - 9-12 awa.

Ihe ngosi maka ojiji

Onye dọkịta na-arịa ọrịa na-arịa ọrịa glibomet ka onye ọrịa na-arịa ụdị shuga 2 n'ọnọdụ ahụ mgbe nri, egwuregwu na ọgwụgwọ mbụ ya na glibenclamide ma ọ bụ metformin adịghị arụ ọrụ. Ọzọkwa, egosiri ọgwụ ahụ maka iji ya dochie ọgwụ maka ndị ọrịa nwere ogo glycemia na-achịkwa ma na-agbanweghi agbanwe.

Edere usoro onunu ogwu na oge ịgwọ ọrịa n’otu n’otu, Dọkịta tụkwasara ọnọdụ steeti carbohydrate onye ọrịa na ogo glucose n’ọbara.

Usoro nke kacha nta bụ 1 mbadamba 3 kwa ụbọchị. Wee dozie usoro onyonyo nke nta nke nta rue mgbe nsonaazụ kacha elu.

Dịka iwu, a na-ewere mbadamba ihe ugboro abụọ n'ụbọchị na mgbede na ụtụtụ n'ụtụtụ n'oge nri.

Usoro kasịnụ nke ọgwụ glybomet bụ nke kachasị 5 mbadamba kwa ụbọchị.

Nsonaazụ

Banyere usoro metabolic, mmepe nke hypoglycemia na mmụba na lactate ọbara. Gbasara traktị ahụ, nyocha na-enye echiche na enwere ike ịnụ ụtọ "ọla" n'ọnụ olu, ọgbụgbọ, ọgbụgbọ na enweghị agụụ.

N'ọnọdụ ụfọdụ, ojiji nke glibometa na-akpata ịba ọcha n'anya, cholestatic jaundice na hyperreactivity nke enzymes imeju. Ọgwụ ahụ nwekwara ike ibute ihe nfụkasị ahụ, gosipụtara n'ụdị urticaria, na-akpasu ọdịdị nke protein na mmamịrị, na-akpata mgbu na nkwonkwo ma na-eme ka ahụ ọkụ dị elu.

Ọzọkwa, nyocha nke ndị na-arịa ọrịa shuga mgbe ha theụsịrị ọgwụ ahụ na-egosi ọnụnọ nke mmeghachi omume akpịrị (fotoensitivity), isi ọwụwa, isi ọwụwa, paresis, dizzness na malaise.

Mgbe ụfọdụ, mgbe ị drinkingụsịrị mmanya, ị ofụ ọgwụ ahụ na-akpata "mmetụta antabuse."

Njirimara

Ekwesịrị ịkọwa ọgwụ glybomet na usoro onunu ogwu n'okpuru nlekọta siri ike nke ọkachamara.

N'ihe banyere lactic acidosis (nkwarụ, ọrịa, vomiting), ọ dị mkpa ịkwụsị iji ọgwụ ahụ ma rụọ ọgwụgwọ dị mkpa.

Ọzọkwa, onye ọrịa ahụ kwesịrị ịrapara na nri nri ụfọdụ, na-ejikwa ọdịnaya glucose na, ọ bụrụ na achọpụtara ihe ịrịba ama nke lactic acidosis, kpọtụrụ dọkịta ozugbo.

Dị Mkpa! Mgbe ị na-eji glibomet, ị gaghị a drinkụ mmanya.

Ntụziaka dị na ọgwụ ahụ dọrọ aka ná ntị: na usoro ịkwọ ụgbọala, glibomet nwere ike imerụ ahụ, n'ihi ewepu ike hypoglycemia.

Dodoụbiga ya ókè

Ọ bụrụ na ọgwụ ndị ahụ na-akpata ịdoụbiga mmanya ókè, mgbe ahụ, ọdịdị nke mgbaàmà dị ka lactic acidosis na-esite na ọrụ nke metformin na hypoglycemia na-esite na ihe nke glibenclamide ga-ekwe omume.

agụụ
malaise
nsogbu akwara ozi
amata aja aja
nhazi nke adighi nma
palpitations
ụra na-atụ mgbe niile
icha mmirimmiri
mmetụta nke ụjọ
paresthesia na onu ogugu,
nsogbu ụra
ịma jijiji
isi ọwụwa
nchebara echiche

Ọ bụrụ na hypoglycemia na-aga n’ihu, mgbe ahụ iwepu mmụọ na njide onwe onye ga-ekwe omume.

Lactic acidosis chọrọ ọgwụgwọ ozugbo na ebe ọrịa inpatient. Ofzọ ọgwụgwọ kachasị dị irè bụ ọgwụgwọ metụtara ọgwụgwọ anụ ahụ.

N'ọnọdụ hypoglycemia dị nro ma ọ bụ nke na-adịghị ala ala, ọ dị mkpa ị toụ sirop ma ọ bụ glucose. Na nnukwu hypoglycemia, a na-enye ntụtụ ịgba ọgwụ glucose (40%) ma ọ bụ glucagon.

Dị Mkpa! Mgbe onye ọrịa nwetaghachiri onwe ya, o kwesịrị iri nri ndị nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Mmekọrịta na ọgwụ ndị ọzọ

Ọgwụ nwere ike ịbawanye hypoglycemic utịp n'ihe banyere myiri ojiji nke dicumarol, oxytetracycline, beta-blockers, sulfonamides, salicylates, chloramphenicol, ethanol, allopurinol, sulfinpyrazone, miconazole, MAO inhibitors, probenecid na cimetidine.

Ọ nwere ike belata homonụ nke thyroid na, ọ bụrụ na ewere ọgwụ ahụ na epinephrine, barbiturates, glucocorticosteroids, thiazide diuretics, mgbochi afọ (mbadamba).

Ọzọkwa, ọgwụ ahụ nwere ike ịkwalite mmetụta nke ị ofụ ọgwụ mgbochi, yana mgbe gị na cimetidine na-emekọrịta ihe, ohere nke lactic acidosis na-abawanye.

Enwere ike ịchọpụta mgbaàmà hypoglycemia n'ihi beta-adrenolocators.

Ntuziaka Maka -lọ Ahụ Maka -lọ Ọgwụ-ọgwụ

Ugbo oru. Oral jikọtara hypoglycemic wakporo, a usoro nke sulfonylurea nke ọgbọ nke abụọ. Ọ nwere nsonji akwara na extrapancreatic. Glibenclamide na-akpali mkpali insulin site na iwetula ọnụ ụzọ maka mgbakasị glucose beta-cell, na-eme ka nnabata insulin na njikọta ya na mkpụrụ ndụ, na-abawanye ntọhapụ insulin, na-eme ka mmetụta insulin dị n’arụ na umeji glucose na-egbochi, na-egbochi lipolysis na adipose anụ ahụ. Ọrụ nke abụọ nke insulin insulin. Metformin na - egbochi gluconeogenesis n'ime imeju, na - ebelata nnabata nke glucose na eriri afọ ma na - abawanye uru ya na anụ ahụ, belata ọdịnaya TG na cholesterol n'ime ọbara. Na-eme ka njikọta insulin na-anabata ndị na-anabata ya (ọ bụrụ na insulin adịghị n'ọbara, anaghị egosipụta ọgwụgwọ ọgwụgwọ). Emeghị mmeghachi omume hypoglycemic. Mmetụta hypoglycemic na-etolite mgbe elekere 2 gachara ma were awa iri na abụọ.

Mlọ ọgwụ Glibenclamide na-agbadata ngwa ngwa na n'ụzọ zuru ezu (84%) na ngọngọ diges, TC max - awa 7-8. Nkwurịta okwu na protein plasma - 97%. Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju ka metabolites na-adịghị arụ ọrụ. 50% akụrụ wepụrụ site na akụrụ, 50% - na bile. T 1/2 - 10-16 awa mgbe ọ gbasasịrị na ngọngọ nri (nnabata - 48-52%), akụrụ na-apụ apụ site na akụrụ (ọkachasị anaghị agbanwe agbanwe), akụkụ ya ụfọdụ. T 1/2 - 9-12 h.

Ihe na-egosi. Elldị nke abụọ nke ọrịa shuga mellitus (na enweghị ọgwụgwọ nke usoro nri ma ọ bụ monotherapy nwere ọgwụ mgbochi hypoglycemic).

Ihe ngbanwe Hypersensitivity, ụdị 1 mellitus diabetes, ọrịa ketoacidosis nke ọrịa mamịrị, ọrịa shuga na coma, lactic acidosis (gụnyere akụkọ ihe mere eme), ọdịda akụrụngwa (creatinine karịa 135 mmol / l na ụmụ nwoke na ihe karịrị 110 mmol / l n'ime ụmụ nwanyị), ọnọdụ ọjọọ , nke nwere ike ibute ọrụ akụrụ na-arụ ọrụ (gụnyere akpịrị ịkpọ nkụ, ọrịa na-efe efe nke ukwuu, ujo, intravascular management nke ayodiin nwere ihe dị iche), ọrịa na-adịghị ala ala tinyere hypoxia anụ ahụ (gụnyere nkụchi obi, iku ume iku ume, nkụchi obi na nso nso a). myoca Ee, ujo), hepatic insufficiency, nnukwu mmanya igbu egbu, porphyria, concomitant ojiji nke miconazole, afọ ime, lactation.

Na-akpachara anya. Alcoholism, enweghị nsogbu nke adrenal, hypofunction nke isi isi, ọrịa thyroid na arụ ọrụ.

Usoro onunu ogwu N'ime, mgbe ị na-eri nri. A na-ahọrọ usoro usoro onunu ogwu n'otu oge, dabere na steeti metabolism. Dị ka ọ na-adịkarị, nmalite amalite bụ mbadamba 1 (2.5 mg glibenclamide na 500 mg metformin), yana ntinye nke ị ga-eji nwayọ were izu ọ bụla ruo 1-2 na-adabere na ntụpọ glycemic.

Mgbe ị na-eji metformin na glibenclamide dochie usoro ọgwụgwọ gara aga, a na-enye mbadamba 1-2 (2.5 mg nke glibenclamide na 500 mg nke metformin), dabere na usoro gara aga nke akụkụ ọ bụla.

Oke kachasị kwa ụbọchị bụ mbadamba 4 (2.5 ma ọ bụ 5 mg nke glibenclamide na 500 mg nke metformin).

Mmetụta akụkụ. Metformin: ọgbụgbọ, ọgbụgbọ, mgbu afọ, agụụ iri, uto "ọnụ" n'ọnụ, etrythema (dị ka ngosipụta nke hypersensitivity), belata mmịpụta na, n'ihi nke a, ịta cyanocobalamin na plasma ọbara (ya na iji ya ogologo oge), lactic acidosis.

Glibenclamide: hypoglycemia, maculopapular rash (gụnyere na mucous membranes), itching skin, urticaria, photoensitivity, ọgbụgbọ, vomiting, erughi ala na mpaghara epigastric, mụbara ọrụ nke transpeases hepatic, ọrịa ịba ọcha n'anya, leukopenia, thrombocytosis, thrombocytopia , aplasia ụmị ọkpụkpụ, pancytopenia, cutaneous na hepatic porphyria, hyponatremia, hypercreatininemia, mụbara urea na plasma ọbara, mmeghachi omume disulfiram (dịka iji ya na oge ethanol).

Dodoụbiga ya ókè. Mgbaàmà: hypoglycemia na lactic acidosis.

Ọgwụgwọ: ya na hypoglycemia (ọ bụrụ na onye ọrịa maara) - shuga dị n'ime, na mwepu nke mmụọ - iv dextrose ma ọ bụ 1-2 ml nke glucagon. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere nnukwu carbohydrates na-adị ngwa ngwa (iji zere ịmalite ịmalite hypoglycemia).

Mmekorita. Miconazole bụ ihe ize ndụ nke hypoglycemia (ruo coma).

Fluconazole - ihe ize ndụ nke ịmalite hypoglycemia (na-eme ka ihe ndị a na-akpọ T 1/2 sulfonylurea).

Phenylbutazone nwere ike ịchụpụ ihe ndị na-egbochi sulfonylureas (glibenclamide) na njikọta na protein, nke nwere ike ibute mmụba na plasma ọbara na ihe ize ndụ nke hypoglycemia.

Ojiji nke radiopaque ọgwụ iodine nwere (maka nchịkwa intravascular) nwere ike ibute mmepe nke ọrụ akụrụ na-abawanye uru na oke metformin, nke na-abawanye ohere nke lactic acidosis. A na-akagbu ọgwụgwọ ya na ọgwụ ahụ awa 48 tupu ọrụ ha, ọ maliteghachiri tupu mgbe elekere 48 gasịrị.

Ojiji nke ethanol nwere ihe dị na ndabere nke glibenclamide nwere ike iduga mmepe nke mmeghachi omume disulfiram.

GCS, beta 2 -adrenostimulants, diuretics nwere ike ibute mbelata arụmọrụ ọgwụ, enwere ike ịchọ ndozi dose.

Ndị na - egbochi ACE - ihe egwu nke hypoglycemia site na iji sulfonylureas (glibenclamide).

Ndị na-egbochi ihe dị iche iche na - eme ka ịbawanye ụba nke hypoglycemia ọgụ.

Ọgwụ antibacterial sitere na otu nke sulfonamides, fluoroquinolones, anticoagulants (counarineri), MAO inhibitors, chloramphenicol, pentoxifylline, ọgwụ na-ebelata mkpụrụ ndụ nke fibrates, na-enupụ isi - ihe ize ndụ nke hypoglycemia site na iji glibenclamide.

Ntụziaka pụrụ iche. Nnukwu ihe ịwa ahụ na mmerụ ahụ, oke ọkụ, ọrịa na-efe efe na ọrịa febrile nwere ike ịchọ mkpochapụ nke ọgwụ glypoglycemic ọgwụ na nchịkwa nke insulin.

Ọ dị mkpa ilebara ọkwa glucose anya mgbe niile n'ọbara na afọ efu na mgbe ị risịrị nri, usoro ụbọchị niile nke ọdịnaya glucose n'ọbara na mmamịrị.

E kwesịrị ịdọ ndị ọrịa ọdụ gbasara ịba ụba hypoglycemia n'ọnọdụ ethanol, NSAIDs, na agụụ.

Imeghari otu ọ̀ dị mkpa maka ịghara oke nri anụ ahụ na nke mmetụta uche, mgbanwe nri.

Edebere ihe nlere anya n'oge ọgwụgwọ na beta-blockers.

Site na mgbaàmà nke hypoglycemia, a na-eji carbohydrates (shuga) eme ihe, n'ọnọdụ ndị siri ike, a na-eji nwayọ nwayọ edozi ngwongwo dextrose.Maka mmerụ ahụ, mmerụ ahụ, ịwa ahụ, ọrịa na-efe efe na ọrịa febrile, ịgbanye insulin ka akwadoro.

Ọ dị mkpa ịkagbu ọgwụ ahụ ụbọchị 2 tupu nyocha ọ bụla ma ọ bụ urographic (ịmaliteghachi usoro ọgwụgwọ 48 awa mgbe nyocha ahụ gasịrị).

Na-emegide usoro iji ihe ethanol nwere, mmeghachi nke mmeghachi omume disulfiram ga-ekwe omume.

N'oge usoro ọgwụgwọ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike ịdị ize ndụ chọrọ mgbanye uche na ọsọ nke mmeghachi omume psychomotor.

Steeti aha ọgwụ. Akwukwo ndi isi: na 2 vol. M: Medical Council, 2009. - mpịakọta 2, akụkụ 1 - 568 s., Nkebi nke 2 - 560 s.

Mmekorita ya na ihe ndi ozo na aru oru

Acarbose na - akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Allopurinol *

Allopurinol na - akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Ascorbic acid *

Na oke onunu ogwu, ascorbic acid (acidifying mmamiri nke ọgwụ) na-eme ka mmelite nke glibenclamide + metformin dịkwuo mma site na iwetulata ọkwa nke ịba ụba na ịba ụba reabsorption nke glibenclamide.

Asparaginase

Asparaginase na-akụda mmetụta nke njikọta glibenclamide + metformin.

Acetazolamide *

Acetazolamide na-akụda nsonaazụ nke glibenclamide + metformin.

Baclofen na-ekwupụta nsonaazụ nke glibenclamide + metformin.

Bezafibrat *

Bezafibrat na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Bromocriptine *

Bromocriptine na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Vancomycin *

Glucagon na-akụda nsonaazụ nke glibenclamide + metformin.

Ọ bụrụ na ọ dị mkpa, nchịkwa nke oge a jikọtara glibenclamide + metformin danazole na mgbe ị kwụsịrị iwere nke ikpeazụ, ịkwesịrị idozi ọnụọgụ nke ngwakọta a n'okpuru njikwa glycemia (danazol nwere mmetụta hyperglycemic ma na-ebelata mmetụta).

Na-ajụ oyi *

Disopyramide na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Isoniazid na-ahụzi mmetụta nke njikọta nke glibenclamide + metformin.

Calcium chloride

Calcium chloride (acidifying mmamịrị nke ọgwụ) na-akwalite nsonaazụ nke glibenclamide + metformin site na mbenata ogo nke dissociation na ịba ụba reabsorption nke glibenclamide.

Captopril na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin ma na-abawanye ohere nke ịmalite hypoglycemic mmeghachi omume site na ịbawanye nnabata glucose na ibelata mkpa insulin.

Miconazole na-eme ka mmetụta nke njikọta glibenclamide + metformin dịkwuo mma, nwere ike ịkpasu mmepe nke hypoglycemia (ruo mmepe nke coma).

Niacin *

Nicotinic acid (na nnukwu usoro) na-ebelata ike nke njikọta nke glibenclamide + metformin.

Nifedipine na-abawanye mgbakwụnye na C max nke metformin ma na-ebelata ntụpọ ahụ.

Pentoxifylline *

Pentoxifylline na-akwalite mmetụta hypoglycemic nke njikọta glibenclamide + metformin.

Pyridoxine *

Pyridoxine na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Procainamide *

Reserpine na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Rifampicin *

Rifampicin na-akụda nsonaazụ nke glibenclamide + metformin.

Salbutamol *

Salbutamol na-akụda nsonaazụ nke glibenclamide + metformin.

Theophylline na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Terbutaline *

Terbutaline na-akụda mmetụta nke njikọta glibenclamide + metformin.

Tetracycline *

Tetracycline na-eme ka mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin dịkwuo mma.

Furosemide mụbara C max metformin site na 22% na AUC site na 15% (na-enweghị nnukwu mgbanwe na mkpocha mkpo). Metformin belata C max furosemide site na 31%, AUC site na 12% na T 1/32 site na 32% (na-enweghị mgbanwe dị ukwuu na mkpochapu mkpo).

Chloramphenicol *

Chloramphenicol na - akwalite mmetụta hypoglycemic nke njikọta glibenclamide + metformin.

Chlorpromazine *

Chlorpromazine na usoro onyonyo dị elu (100 mg / ụbọchị) na-akụda nsonaazụ nke glibenclamide + metformin, n'ihi na-eme ka mmụba nke glycemia.

Chlortalidone *

Chlortalidone na-ahụ maka mmetụta nke njikọta glibenclamide + metformin.

Cimetidine (ọgwụ cationic) zoro ezo na tubules na-asọ mpi maka usoro ụgbọ njem tubular ma na-abawanye C max metformin na 60% na AUC site na 40%.

Enalapril na-eme ka mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin dịkwuo elu ma na-eme ka ohere nke ịmalite hypoglycemic mmeghachi omume site na ịbawanye nnabata glucose na ibelata mkpa nke insulin.

Epinephrine na-akụda nsonaazụ nke glibenclamide + metformin.

Site na nhazi nke oge nke nchịkọta nke glibenclamide + metformin na mmanya, ihe ize ndụ nke ịmaliteghachi mmeghachi omume hypoglycemic, gụnyere ikpe nke coma, na lactic acidosis na-abawanye, ya mere, a ga-ezere njikwa mmekọrịta.

Ethionamide na-akwalite mmetụta hypoglycemic nke njikọta nke glibenclamide + metformin.

Ọtụtụ mgbe n'ọgwụgwọ ụdị ọrịa shuga dị n'ọrịa 2, ọ ezughị iji naanị otu ụzọ abụọ nke mbadamba shuga dị ala. Biguanides na ihe ndị ọzọ kwesịrị ịgbakwunye na usoro ọgwụgwọ site na usoro sulfonylurea.

Ndị na-ahụ maka ọgwụ na-emepụta ọgwụ Glibomet, nke bụ njikọta ihe ịga nke ọma nke ìgwè abụọ na nke ọma, ekele ụzọ dị iche iche nke mkpughe, si edozi nsogbu nke ndị mmadụ na-arịa oria a.

Glibomet ogwu bu n’ezie ime ka onodu shuga di n’obara ndi oria nwere oria nke abuo, n’enwe ike iweta suga n’obara na usoro nri, n’eburu uzo sulfonylurea ma obu biguanides enweghi ihe ịga nke ọma.

Ihe mejupụtara ọgwụ ahụ gụnyere ihe 2 na-arụ ọrụ:

glibenclamide 2.5 mg - onye nnọchi anya ọgbọ nke abụọ nke usoro sulfonylurea,
Metformin 400 mg bụ ihe dị iche iche nke biguanides.

Mpempe akwụkwọ na-eme mbadamba ihe dị iche iche na-anọchi anya ya.

A na-eji tebụl tebụl dị n’elu mbadamba nkume ndị ahụ na mgbakwunye nke otu n’ime ụdị cellulose na diethyl phthalate.

Omume ọgwụ

Site na iburu mbadamba Glibomet, ebumnuche abụọ na-emezu:

Mbelata shuga dị ka ọkwa nkịtị,
ụkpụrụ nke abụba metabolism.

Gịnị kpatara omume ndị a? Akụkụ nke ọ bụla na arụ ọrụ:

Glibenclamide na - eme ka mmiri ọgwụ insulin dị na palpanas mee ka ọ dịkwuo mma ma na - eme ka uru anụ ahụ dị na - aga n'ihu (mmetụta extrapancreatic). N'okpuru mmetụta ya, glucose sitere na akwa akwara na-abanye n'ime hepatocytes na banye akwara, ebe a na-emepụta ebe obibi glycogen.
Metformin na - eme ka ahụrịị akwara anụ ahụ dị na insulin, na - egbochi nnabata nke glucose na tube eriri afọ, na - egbochi njikọta ya n'oge gluconeogenesis, ma na - eme ka metabolism abụba dịkwuo elu.

Mmetụta mmekọrịta nke ihe abụọ ahụ na-enye aka belata nchikota nke nke ọ bụla na-enweghị ajọ mbunobi nke ọgwụgwọ, nke na-eme awa 2 mgbe nchịkwa ma dịgide ruo awa iri na abụọ. Na mgbakwunye, nke a na-ebelata ohere nke mmetụta ndị ọzọ.

N'ime ahụ, glibenclamide na metformin na-akpa àgwà dị iche iche. Glibenclamide jikọtara ya na protein ndị dị na plasma ma bụrụkwa nke mejupụtara ya na imeju, ma emesịa ya site na mmịpụta na mmamịrị n'ụdị metabolites na - adịghị arụ ọrụ. Metformin anaghị abanye protein ahụ, ọ na-abanye n'ime akwara, ebe ọ na-arụ ọrụ na-enweghị ihe ọ bụla metabolized. A na - etepụ ya bụ mmamịrị, ntakịrị oge na eriri afọ.

Ntụziaka maka ojiji

A kọwara ozi banyere ụzọ isi nchịkwa na usoro onodu ogwu ya na ntuziaka maka ojiji nke Glibomet.

Enwere naanị otu ụzọ ị ga-esi medicineụọ ọgwụ ahụ - a na-eji ọgwụ eme mbadamba nkume ndị ahụ. Usoro izizi sitere na mbadamba 1 ruo 3 kwa ụbọchị. N'ọdịnihu, endocrinologist na-ahọrọ usoro ọgwụgwọ nke onwe ya, na-eburu n'uche ọnọdụ onye ọrịa na ọkwa shuga. Oke kachasị kwa ụbọchị ekwesịghị ịfe mbadamba isii.

Usoro ọgwụgwọ dọkịta họọrọ ka a na-edobe ya mgbe ọ na-akwado ya na ịchịkwa shuga. Ebumnuche nke ịhọrọ ọgwụ bụ iji hụ na ịhazi ọkwa shuga dị n'ọbara.

Ekwesịrị ilezi anya mgbe ị na-anya ma jiri igwe na-akpụ akpụ na-arụ ọrụ.

Mmekọrịta na ọgwụ ndị ọzọ

Mmekọrịta na ọtụtụ ọgwụ na-eduga n'ịbawanye uru hypoglycemic. Ndị a gụnyere:

coumarin nkwadebe,
salicylates,
ihe mgbochi beta
sulfonamides,
MA inhibitors
miconazole
mmanya ethyl.

Glibomet na-abawanye nsonaazụ anticoagulants.

Mmetụta ọzọ nke hypoglycemia bụ:

glucocorticoids,
ọgwụ mgbochi
mkpụrụ nke usoro thiazine,
mgbochi ego
adrenaline
homonụ thyroid.

Ndị na-egbochi Beta na-eme ka ngosipụta nke hypoglycemia pụta ìhè, nke nwere ike ịdị ize ndụ maka onye ọrịa mamịrị.

Iodine iche-iche na-agbanye n'ime akwara na-enye aka na nchịkọta nke metformin, yabụ enwere ihe iyi egwu nke lactic acidosis.

Enwere analogues nke Glibamet n'omume na ihe mejupụtara.

Glucovans bụ nkwakọkọta jikọtara ọnụ nke hypoglycemic action, nke Merck, France mepụtara. Mbadamba ụrọ nke mebere glibenclamide na metformin na mbadamba ihe dị mbadamba iri na ise. Na ngwugwu 2 ma ọ bụ 4 blisters.
Metglib - nwere ihe mebere ya, mbadamba iri anọ n’otu ngwugwu.
Bagomet-gbakwunyere - otu ihe ahụ dị ihe 2 na-arụ ọrụ, mana usoro onyonyo ahụ dịtụ iche. Na ngwugwu nke mbadamba iri atọ. Argentina emeputa.
A na-enweta Gluconorm - ngwakọta nke otu ihe abụọ ahụ, iberibe 40 nke ọ bụla, sitere na India.
Ihe omumu Glibomet di iche na mejuputara ma ha ndi yiri ya na ihe gụnyere:
Amaryl sitere na glimepiride 1.2.3.4 mg na blisters nke iberibe 15, na ngwugwu nke 2, 4, 6 ma ọ bụ 8 blisters. Ọ dị na Germany.
Maninil na Diabeton - nke sitere na glibenclamide, bụ usoro nke sulfonurea ọgbọ nke abụọ.
Maninil - mbadamba 1,75 mg, 3.5 mg na 5 mg nke 120 iberibe. Emeputa - Berlin-Chemie, Germany.
Diabeton MV - 30 mbadamba 60 nke mbadamba 60 ma ọ bụ 30, n'otu n'otu. Servier Laboratory, France na-ebubata ọgwụ.

Na ntụle, a ga-enye Diinonon Maninil - Diabeton dịka ọgwụ na-adịghị emerụ ahụ.

Na ọnụahịa, Glybomet na ihe ọ na-ekwuchitere ya na mkpokọta ya.

Ọnụ ego dị elu maka Glibomed bụ site na 200 ruo 300 rubles.
Glucovans - ọnụahịa ahụ dị na 250 - 350 rubles.
A na-ere Bagomet-gbakwunyere maka 225 -235 rubles.
Enwere ike ịzụta Metglib na nkezi maka 230 rubles.
Maninil na-akwụ ụgwọ 130 -170 rubles.
Ọrịa mamịrị n'ime oke nke 159 - 202 rubles.
Ọnụahịa nke Amaryl sitere na 150 ruo 3400 rubles. A na-ere Amaryl na ọnụahịa kachasị elu na usoro kachasị ukwuu nke 4 mg nke mbadamba 90.

Home »Cholecystitis» Glibomet - ntuziaka maka iji ọgwụ ahụ, nyocha. Ọgwụ Hypoglycemic nke abụọ nke glybomet

Uzo esi ewere Glibomet

Na-ekpe ikpe site na nyocha nke endocrinologists, iji zere lactic acidosis, ndị ọrịa mamịrị karịa afọ 60, na mgbatị ahụ dị arọ kwa ụbọchị, ịkwesịrị ị theụ ọgwụ ahụ na nlezianya, na-edekọ glucometer ahụ n'otu oge.

Enwere ikike mgbochi iwere Glibomet:

Ngwakọta na ịhapụ ụdị

Ngwakọta nke mbadamba Glibomet gụnyere ihe abụọ na-arụ ọrụ, nke bụ glibenclamide, yana metformin hydrochloride, oke nke ihe ndị a bụ 2.5 mg na 400 mg, n'otu n'otu. Agbakwunye dị ugbu a:

Glycerol dibehenate
Povidone
Colloidal silicon dioxide
Stereta magnesium
Croscarmellose sodium
Macrogol.

Mbadamba nkume ndị ahụ dị gburugburu, na-acha ọcha, na-adị ize ndụ n'otu akụkụ. A na-etinye mbadamba na paịlị dị mbadamba 20., N'ime mkpọ 2 blisters.

Ngwongwo na-agwọ ọrịa

Glibomet bụ ọnụ ọgụgụ ọgwụ hypoglycemic nwere ihe mejupụtara, ihe ndị na-arụ ọrụ bụ ihe dị n'ụkpụrụ sulfonylurea, yana biguanide ọgbọ nke abụọ. Ọgwụ ahụ na-eme ka njikọ insulin na plọgas na-ebelata ala nke mgbakasị ahụ by-cell site na glucose n’onwe ya. Ihe ahụ na-amụba ike ịba insulin, ebe ihe jikọtara ya na mkpụrụ ndụ ndị a kapịrị ọnụ na-abawanye, ntọhapụ insulin na-adịkwa mma. N'oge ọgwụgwọ antidiabetic, usoro glucose nke mkpụrụ ndụ imeju na akwara na-enweta glucose, ọ na-egbochi lipolysis na-eme na anụ ahụ adipose. Edere ngosipụta nke glibenclamide na ọkwa nke abụọ nke insulin insulin.

Metformin bu onye otu ndi otu biguanide. Ọ nwere mmetụta na-akpali akpali na akwara nke anụ ahụ na insulin, na-ebelata usoro glucose glucose na eriri afọ, na-egbochi gluconeogenesis, ma na-emetụta ọfụma nke metabolism metabolism. Na-emegide usoro a akọwapụtara, ọ ga-ekwe omume iwelata oke ahụ n'ahụ ndị mmadụ na-arịa ọrịa shuga ngwa ngwa.

A na-edekọ mmetụta hypoglycemic nke ọgwụ Glibomet ruo elekere 2 mgbe oge mbadamba mbadamba ahụ wee chekwaa awa iri na abụọ na-esote. N'ihi njikọta nke ihe abụọ na-arụ ọrụ, njikọta nke ihe a na-akpọ endogenous insulin na-arụ ọrụ, biguanide nwere mmetụta ọ bụghị nanị na akwara na adipose, kamakwa na anụ ahụ (n'ihi mbelata gluconeogenesis). N'okwu a, anaghị edekọ mkpali siri ike nke β-cell nke pancreas, nke na-ebelata ohere nke ọrịa akụkụ na mmepe nke ọtụtụ akụkụ mgbaàmà.

Ọkwa nke glibenclamide site na mucosa eriri afọ bụ ihe dịka 84%. Edere ọnụego kachasị nke ihe a n'ime ọbara n'ime awa 1-2 ka ejiri ọgwụ mee ihe. Nkwurita okwu na protein ndi na - eme ka plasma - 97%. Mgbanwe Metabolic nke ihe a na - apụta na sel imeju; n'ihi nke a, etolite ọtụtụ metabolites na - adịghị arụ ọrụ. Na iwepu ngwaahịa metabolic, eriri afọ na usoro akụrụ na-etinye aka. Iwepu ọkara ndụ anaghị abụkarị awa 5-10.

Nnabata nke metformin nke mucosa eriri afọ dị oke elu. Mgbe ị na-abanye na mgbasa nke sistemụ, a na-ahụta nkesa ngwa ngwa na anụ ahụ, ọ fọrọ nke nta ka ọ banye na mmekọrịta ọ bụla na protein plasma. Ihe a mebere metabolized, nke sistemu akwara napụrụ ya. Ọkara ọkara nke metformin bụ 7 awa.

Glibomet: ntuziaka zuru ezu maka ojiji

Ezubere ọgwụ a maka nchịkwa ọnụ. Were nri Glybomet. A na-ahọpụta usoro usoro ọgwụgwọ na usoro ọgwụgwọ n’otu n’otu n’ileba anya n’ihe ngosipụta ahụike dị, ọkwa nke glucose dị n’ọbara, yana kwa foto nke metabolism metabolism dị.

Ọtụtụ mgbe, usoro ị nweta ọgwụ mbụ Glibomet bụ mbadamba 1-3. Ugbua n'oge ọgwụgwọ antidiabetic, a na-ahọrọ ọgwụ kachasị dị irè, nke na-enye ohere belata ọkwa glucose na ụkpụrụ nkịtị. Ọ dị mma ịmara na ịsụ ọgwụ kachasị elu kwa ụbọchị bụ mbadamba isii.

Nkọwa nke ihe mejupụtara. Mgbapụta Ọgwụ Ọgwụ

Ọgwụ "Glibomet" dị n'ụdị mbadamba gburugburu ọcha na-enwe shei siri ike. A na-etinye ha na blisters dị mma nke iberibe iri abụọ. N'ime ụlọ ahịa ọgwụ ị nwere ike ịzụta ngwungwu nke nwere blisters abụọ.

Ngwunye a jikọtara ọnụ, ya mere, ihe mejupụtara nwere ihe abụọ na - arụ ọrụ - glibenclamide (2.5 ml n'ime otu mbadamba) na metformin n'ụdị hydrochloride.N'ezie, nkwadebe ahụ nwekwara ihe ndị na-enyere aka, akpan akpan, ọka ọka, silicon dioxide, microcrystalline cellulose, talc, diethyl phthalate, glycerin, cellulose acetate phthalate, gelatin.

Kedu ka ọgwụ si emetụta ahụ?

N'ezie, ịmalite, ọ bara uru ịghọta akụrụngwa nke ọgwụ. A na-ekpebi mmetụta hypoglycemic nke nkwadebe Glibomet site na ọdịnaya nke ihe abụọ dị ike n'otu oge.

Ngwá ọrụ a na-arụ ọrụ na pancreas, ya bụ mpaghara ndị ahụ na-ahụ maka ahụ. N'otu oge ahụ, ọgwụ a na - akwalite ọgụgụ isi nke mkpụrụ ndụ elele na homonụ a. Ya mere, Glibomet na-enyere aka belata shuga ọbara na-ejighị insulin sịntetik, nke dị oke mkpa maka ụdị shuga 2.

Ọgwụ nwekwara akụrụngba na-egbusi ike. N'okpuru ike ya, ọkwa nke abụba dị n'ọbara na-ebelata, nke a na-ebelata ohere nke egbochi mkpụkọ ọbara (clots ọbara). Metformin bụ otu nke biguanides. Ihe a na - eme ka usoro glucose na - arụ ọrụ site na akwara, na - egbochi gluconeogenesis na akwara nke imeju, na - egbochi mgbidi nke eriri afọ.

Glibenclamide na-ejide mgbidi nke eriri afọ ngwa ngwa, ọ fọkwara nke nta (97%) na protein protein. N'ime imeju, ọ na-agbadata, na-akpụ metabolites na-adịghị arụ ọrụ, nke ahụ ewepụrụ na ahụ yana oke yana mmamịrị. Nkeji ọkara bụ awa ise. A na-etinye Metformin ngwa ngwa n'ime ahụ, mana ọ dịghị agbanye na protein plasma. Ihe ndị a adịghị metabolized n'ime ahụ. hà ka awa abụọ.

Kedu mgbe eji ọgwụ ahụ?

Ọtụtụ mmadụ na-arịa ọrịa dịka ọrịa shuga 2. Nri na ọgwụgwọ na nke a dị ezigbo mkpa. Dịka iwu, maka ndị ọrịa mejupụta nri kwesịrị ekwesị. You nwere ike idozi ọbara ọbara gị na sulfonylureas.

A na-enye ọgwụ "Glibomet" ma ọ bụrụ na usoro ọgwụgwọ na ị nweta ego ndị dị n'elu anaghị enye nsonaazụ dị mkpa.

Etu esi ewere ọgwụ "Glibomet"? Usoro onunu ogwu ekpebi n’otu n’otu. Dịka iwu, usoro mbido bụ mbadamba abụọ. Eji ha rie nri. Ọzọkwa, ọnụ ọgụgụ ọgwụ a na-abawanye iji nweta nsonaazụ kachasị. Dosebọchị kwa ụbọchị ekwesịghị gafere 2 g nke metformin. Na-esote, a na-eji nwayọ belata ọgwụ ahụ.

Ọgwụ "Glibomet": contraindications maka ọgwụgwọ

Nke a bụ ọgwụ dị ike ma sie ike, nnabata nke ga-ekwe omume naanị site n'ikike nke dọkịta. Ọgwụ nwere ezigbo ụtọ contraindications, nke ị kwesịrị ịmara nke ọma tupu ịmalite ọgwụgwọ:

hypersensitivity na arụmọrụ na aka inye aka nke mbadamba,
Ihe ndị ọzọ na-emetụta ihe ndị ọzọ na sulfernlurea, yana sulfamide, probenecid ma ọ bụ sọlfọ sulfuride,
a na - egbochi ọgwụ a na ụmụ nwanyị n'oge afọ ime,
enweghị mmetụta ọgwụgwọ,
ọrịa shuga na ọnọdụ preomatous
oke nsogbu akụrụngwa, ọdịda akụrụ,
akpịrị ịkpọ nkụ
ọrịa na-efe efe
Ọrịa mkpali nke nwere ike ibute mmepe nke hypoxia anụ ahụ,
ajọ ọrịa nke usoro akwara obi, gụnyere nsogbu na mgbasa akwara, ụkwara myocardial, nsi na-efe efe na ujo obi,
ọrịa ndị gara aga nke usoro iku ume,
infarction myocardial ma ọ bụ oge ume ike ọ gasịrị,
n'out oge eji diuretics na ọgwụ maka ọbara mgbali elu.
acidosis ma ọ bụ ihe ize ndụ nke mmepe ya,
ọnụnọ nke akụkọ onye ọrịa banyere ọrịa lactic acidosis,
nnukwu ọrịa imeju
nsogbu nke usoro iku ume,
oge ịgbazigharị mgbe enwerechara akụkụ anụ ahụ,
ọrịa dystrophic,
a chronicụrụma, mmanya na-egbu egbu,
nnukwu ọbara ọgbụgba
agba egbe
lactation
na-ebu ọnụ ma ọ bụ soro nri siri ike.

Ọ bụrụ na ị nwere nke ọ bụla n'ime contraindications dị n'elu, mgbe ahụ, ọ bara uru ịkọrọ ndị endocrinologist.

Mmeghachi omume ọjọọ ndị dị a therapyaa ka ọgwụ na-akpata?

A na-atụle ya mgbe niile dị mma iji were mbadamba Glibomet? Mmetụta dị iche iche na ndabere nke ọgwụgwọ ga-ekwe omume. A na-edekọghị ọnọdụ nke omume ha ugboro ugboro, mana ọgwụgwọ nwere ike imetụta usoro ahụ dị iche iche.

Sistem Lymphatic na ọbara . Hemolytic anaemia, leukopenia, thrombocytopenia, pancytopenia, erythrocytopenia.
CNS . N'oge isi ọwụwa na - abịakwasị ya, na - ahụkarị ihe ụtọ n'anya.
Org nke ọhụụ. Ọgba aghara nke ebe obibi, belata akwara anya, nke metụtara mgbanwe shuga ọbara.
Metabolism . Mmụba dị ukwuu n’arụ ahụ, hypoglycemia, lactic acidosis. Ọgwụ ogologo oge na-eduga mgbe ụfọdụ ị imụ vitamin B12 na eriri afọ, nke na-esote mmepe nke anaemia megaloblastic.
Usoro nri . Ogbugbu, ọgbụgbọ, ọgbụgba, ihe mgbu na mpaghara nke ụdọ, ụfụ ugboro ugboro, agụụ na-egbu mmadụ, ọdịdị nke uto ọla n'ọnụ, mmetụta nke afọ.
Akpụkpọ anụ na anụ ahụ dị n'okpuru ala . Ahụ mgbu, erythema, ụdị exanthema dị iche iche, ịba ụba nke anụ ahụ na ọkụ, nfụkasị dermatitis, urticaria.
Mmeghachi omume nfụkasị ahụ . Rashes na anụ ahụ, ọzịza, jaundice, mbelata ọbara mgbali elu, nkụda mmụọ iku ume, ọnọdụ ujo.
Imeju . Intrahepatic cholestasis, ịba ọcha n'anya ọgwụ.
Complicfọdụ nsogbu ndị ọzọ nwere ike pụta, ọkachasị, mmụba na mmụba kwa ụbọchị, ọnwụ nke protein na sodium site n'ahụ ya n'ihi mmetọ ahụ akụrụ.

Ọ dị mma ịmara na ọtụtụ nsogbu ndị dị n'elu anaghị achọ ịkwụsị ọgwụgwọ - o zuru ezu iji belata dose ahụ na mmeghachi omume na-apụ n'anya na onwe ha. Kwa ụbọchị ọgwụ a ga-amụba nwayọ nwayọ.

Ozi gbasara mmekọrịta na ọgwụ ndị ọzọ

Enweghị ike ị beụ ọgwụ ahụ "Glibomet" (metformin) na mmanya ethyl, n'ihi na nke a na-eme ka ohere nke ịmalite lactic acidosis nwee ike ibute ya. N'oge usoro ọgwụgwọ, a ghaghị ị alcoholụ mmanya na ihe ọ containingụ alcoholụ nwere mmanya na-egbu egbu.

Ọgwụ nke ọgwụ a na-akwụsị na awa 48 tupu usoro nke ejiri iodine nwere ihe dị iche na-eji ihe dị iche iche eme ihe. Oge a ọgwụ ndị a n’otu oge nwere ike ibute mmepe nke ọdịda akwara.

Ọ bụrụ na ị were "Glibomet" yana insulin, steroid anabolic, ihe mgbochi beta-adrenergic, ọgwụ tetracycline, mgbe ahụ ihe ize ndụ nke ịmalite hypoglycemia na-abawanye. Ndị ọrịa mamịrị kwesịrị ịgwa dọkịta ha banyere ọgwụ niile ha na-a .ụ.

Akwụ ụgwọ na analogues

N'ime ọgwụ ọgbara ọhụrụ, a na-ejikarị ọgwụ "Glibomet". Nyocha nke ndị ọrịa mamịrị, ihe ngosi na contraindications, n’ezie, isi ihe dị mkpa. Ma ọ dịghị ihe dị mkpa dị mkpa bụ ọnụ ahịa ya. N'ezie, ọ siri ike ịkpọ aha ọnụ ọgụgụ ahụ kpọmkwem, mana na nkezi ọnụahịa nke ngwugwu 40 mbadamba sitere na 340 ruo 380 rubles, nke bụ n'ezie abụghị nke ukwuu.

N'ezie, ọgwụ a anaghị adabara ndị ọrịa mgbe niile. E nwere ihe nnọchi zuru ezu n'ahịa ọgwụ ọgbara ọhụrụ. Iji maa atụ, na-arịa ọrịa shuga nke ụdị nke abụọ, dịka Avandamet, Vokanamet, Glukovans na-ejikarị. Ọ naghị erughị oge, a na-enye ndị ọrịa Dibizid, Dianorm ma ọ bụ Sinjarji. N'ezie, naanị endocrinologist na-abịa nwere ike ịhọrọ analog dị irè.