Etu esi etinye Lisinopril Stad dịka ntuziaka ahụ si dị?

A na-emepụta Lisinopril site na ọtụtụ ụlọ ọrụ ọgwụ, dị ka Avant, ALSI Pharma, Severnaya Zvezda, Ozone LLC, Stada, Teva na ndị ọzọ. Ya mere, ọgwụ ahụ nwere aha dị iche iche ejiri na ahịa ọgwụ:

Lisinopril Stada,
Lisinopril Teva,
Lisinopril SZ,
Diroton
Dapril na ndị ọzọ.

Ọgwụ ndị a niile na-arụ ọrụ n'ihi nsị nke lisinopril.

Yabụ kedu ka lisinopril si dị iche na lisinopril stad? Nke mbu, ulo oru ogwu di iche iche meputara ha. Lisinopril Stada bụ Makiz-Pharma LLC (na Moscow) na Hemofarm (na Obninsk) mepụtara. Ndị a na-emepụta bụ nke ụlọ ọrụ Stad ma na-emepụta ọgwụ dịka ụkpụrụ European si dị.

Nke abuo, ngwaahịa a nwere ndi ozo di iche. Dịka ọmụmaatụ, Lisinopril nke Alsi Pharma nwere shuga mmiri ara ehi, MCC, stachi, silica, talc, magnesium stearate. Nkwadebe nke ụlọ ọrụ ahụ Stada, dịka ozi sitere na ntuziaka maka ojiji, na mgbakwunye na ihe ndị ahụ edepụtara n'elu, gụnyere ihe ndị dị ka mannitol, ludipress (shuga mmiri ara ehi na povidone), sodium croscarmellose, protein hydrogen phosphate.

Ihe ngosi maka ojiji

Ntụziaka ahụ nyere ikike iji Lisinopril Stad maka:

ọbara mgbali elu (naanị ma ọ bụ ya na ọgwụ ndị ọzọ),
nkụchi obi (yana mgbakwunye na obi glycosides, diuretics),
infarction myocardial (n'ime ndị ọrịa nwere hemodynamics kwụsiri ike. Ọ dị mkpa na ụbọchị mbụ),
Ọrịa akụrụ na ọrịa shuga (na-agbada protein na mmamịrị ya na ọrịa shuga nke 1 na-enwe nrụgide nkịtị na ndị ọrịa nwere ụdị ọrịa shuga 2 na-arịa oke ọbara).

Ngwakọta, nkọwa, ụdị usoro onunu ogwu, otu

Stlọ ọrụ ahụ Stada na-emepụta Lisinopril n'ụdị mbadamba 5, 10 na 20 mg. A na-akwakọ ha na PVC na foil. Ihe mbụ eji eme ya bụ na kaadiboodu. E nwekwara ntuziaka maka ojiji. Na ire ị ga-enweta ngwugwu nke mbadamba 20 na 30.

Ọgwụ gụnyere lisinopril dihydrate na ihe inyeaka nke edepụtara n’elu.

Ntuziaka maka iji nye ozi na Lisinopril Stada bụ mbadamba ihe ọcha (ude ga-ekwe omume), cylindrical, nwere ebe njedebe dị egwu na ihe egwu.

Ntụziaka ahụ na-ezo ọgwụ ahụ n'ìgwè nke ndị na - egbochi ACE. Otu ọgwụ ọgwụ:

na-ebelata ntụgharị nke angiotensin I na angiotensin II, nke na-eduga na mbelata nke mwepụta nke aldosterone,
na-egbochi mmebi bradykinin,
na-eme ka e guzobe prostaglandins.

Usoro ndị a na-eduga na mgbochi nke usoro renin-angiotensin-aldosterone. Yabụ, maka ị ofụ ọgwụ, vasodilation na mbelata ọbara mgbali na-apụta.

Mmalite nke mmetụta ahụ na-apụta otu awa mgbe nchịkwa ma dịgide ruo ụbọchị. Mmetụta kwụsiri ike pụtara mgbe ụbọchị 30-60 jiri Lisinopril Stad. Ntụziaka ahụ na-ekwu na enweghị “nkwụghachi nkwụchi” mgbe ọ kwụsịrị iji. Ọzọkwa, ọgwụ a na-ebelata ogo protein na mmamịrị.

Nhọrọ Nhọrọ na Usoro Ojiji

Ntụziaka ahụ na-ekwu na ọgwụ Lisinopril Stada ezubere maka ọnụ. A ga-eji mmiri were mbadamba nkume ndị ahụ. Anabatara n'agbanyeghị nri.

Jiri 1 mbadamba ụbọchị kwa ụbọchị. Ọ bụ dọkịta na-ahụ maka ịga akwụkwọ ka dọkịta depụtara ya dabere na ọnọdụ onye ọrịa ahụ. A na-ahọrọ ego dị mkpa ruo mgbe achọrọ ọkwa mgbali elu ọbara. Ọ bụghị ihe amamihe dị na ịbawanye usoro onunu ogwu tupu ụbọchị 2 mgbe mmalite nke iji. Ntụziaka ahụ gosipụtara ụzọ na usoro ojiji:

n'ihe banyere ọbara mgbali elu, mmalite a bụ 10 mg kwa ụbọchị, ihe mmezi ahụ bụ 20 mg,
kacha nnabata nke 40 mg na otu ụbọchị.
Tupu ịmalite ọgwụgwọ na Lisinopril, ịkwesịrị ịkwụsị iji diuretics ruo ọtụtụ ụbọchị.
ọ bụrụ na ọ gaghị ekwe omume ịkagbu ha, mgbe ahụ ịmalite ọgwụ ahụ, dịka ntuziaka ahụ si dị, agaghị enwe ike karịa 5 mg kwa ụbọchị.
A na-ewere usoro izizi ahụ n'okpuru nlekọta ahụike.

Site na ọbara mgbali oke nke mebere arịa ahụ akụrụ, ha na-ebido site na ntụtụ nke 5 mg n'okpuru nlekọta n'ụlọ ọgwụ. Ntụziaka a na-enyocha ileba ọbara ọgbụgba, ọnọdụ akụrụ, yana ụba nke potassium n'ime ọbara. Ọkwa mmezi dabere na ọkwa ọbara mgbali elu. Onye dọkịta depụtara ya.

Maka nsogbu akụrụ, a na-ahọrọ dose ahụ, na-eburu n'uche mkpochapụ creatinine, ego nke sodium na potassium na ọbara.

Na CHF, nkuzi a na-atụ aro iji otu Lisinopril Stad:

nmalite amalite - 2.5 mg kwa ụbọchị,
na - akwado - 5-10 mg kwa ụbọchị,
kachasị 20 mg kwa ụbọchị.

Na njikọta, iji glycosides, diuretics dị mkpa.

Site na ischemic necrosis nke obi (nkụchi obi), a na-eji Lisinopril Stada mee ụlọ ọgwụ yana usoro njikọta. Onu ego nke dibia a hoputara hotara. N'ikuku amalite ụbọchị mbụ. Ejiri ndị ọrịa nwere hemodynamics kwụsiri ike.

Ntuziaka maka ojiji akwadoro ụdị atụmatụ a:

ụbọchị mbụ - 5 mg,
mgbe ụbọchị 1 gasịrị - 5 mg,
mgbe ụbọchị 2 gasịrị - 10 mg,
emesịa - 10 mg kwa ụbọchị.

Maka nephropathy mamịrị, Lisinopril Stada na-eji 10 mg kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, mee ka ego ahụ gaa na 20 mg.

Mmekorita

Ntụziaka maka iji rụba ama mmekọrịta ndị a:

ya na nkwado ndi potassium, ihe ndi n’eme ka aru puo nke sitere na potassium (Veroshpiron na ndi ozo) na cyclosporine, enwere ihe ọghọm nke mmụba na ụba nke potassium n’ime ọbara.
yana ọgwụ ndị ọzọ na-ebelata ọbara mgbali elu - jikọtara ọnụ na-eme ka mmụba ahụ dị,
ya na psychotropic na vasodilator - mbelata nke mgbali ọbara,
yana nkwadebe lithium - mmụba nke ọkwa lithium n’ahụ,
ya na antacids - mbelata nke nnabata nke lisinopril na ngha,
ya na hypoglycemic - Ntụziaka na-atụle ihe ize ndụ nke hypoglycemia,
ya na NSAIDs, estrogens, adrenergic agonist - mbelata nke mmetụta hypotensive,
eji nkwadebe ọla edo - ọbara ọbara nke anụ ahụ, nsogbu nke dyspeptik, wedata ọbara mgbali elu,
ya na allopurinol, novocainamide, cytostatics - ijikọtara ọnụ nwere ike itinye aka na leukopenia,
na ethyl mmanya - mmụba nke lisinopril.

Ihe ngbanwe

Hypersensitivity na lisinopril ma ọ bụ ndị ọzọ na-egbochi ACE, ịtụrụ ime, lactation. Akụkọ banyere ọrịa angioedema n'oge ọgwụgwọ ya na ndị na - egbochi ACE, ihe nketa ma ọ bụ idiopathic angioedema, aortic stenosis, ọrịa ụbụrụ (gụnyere ụbụrụ), ọrịa obi obi, ụkwara ume ọkụ, ụkwara akwara siri ike, ọrịa systemic autoimmune systemic tissue. , scleroderma), mwepu nke ụmị ọkpụkpụ, ọrịa mellitus, hyperkalemia, akwara akwara akwara, stenosis nke otu akụrụ akwara, ọnọdụ mgbe ọ gbasesịrị akụrụ, ọdịda akụrụngwa, nri nwere mmachi nke Na +, ọnọdụ tinyere Mbelata BCC (gụnyere afọ ọsịsa, ọgbụgbọ), ịka nká, afọ rue afọ 18 (amabeghị nchekwa na arụmọrụ).

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, yana ọbara mgbali elu - 5 mg otu ugboro n'ụbọchị. Na enweghị mmetụta, a na-abawanye dose ahụ kwa ụbọchị 2-3 site na 5 mg gaa na nkezi usoro ọgwụgwọ nke 20-40 mg / ụbọchị (ịba ụba dose ahụ karịa 20 mg / ụbọchị anaghị ebute mbelata ọbara mgbali ọzọ). Oke kachasị kwa ụbọchị bụ 80 mg.

Site na HF - bido na 2.5 mg otu oge, mmụba ọgwụ nke 2.5 mg mgbe ụbọchị 3-5 gachara.

N'ime ndị agadi, a na-ahụkarị mmetụta na-adịte aka hypotensive, nke a na-ejikọ ọnụ na mbelata mkpịsị lisinopril (a na-atụ aro ịmalite ọgwụgwọ na 2.5 mg / ụbọchị).

Na ọdịda akụrụngwa na-adịghị ala ala, nchịkọta na-apụta mbelata mkpochasị ihe na-erughị 50 ml / min (a ga-belata ọnụọgụ ya ugboro abụọ, na CC erughi 10 ml / min, a ga-belata dose ahụ site na 75%).

Site n'ọbara mgbali elu na-adịgide, a na-egosi ọgwụgwọ ọgwụgwọ ogologo oge na 10-15 mg / ụbọchị, na nkụchi obi - na 7.5-10 mg / ụbọchị.

Nsonaazụ

Ntụziaka maka iji ya kwuo na n'oge ọgwụgwọ Lisinopril Stad, ihe ịtụnanya na - eme na akụkụ na sistemụ na - esote:

akwara obi na akwara ọbara (orthostatic hypotension, adịkarịghị enwe mmụba na mkpụrụ obi, nsogbu ọbara na akwara aka, nkụchi obi, ọnya afọ).
CNS (obi ilu, isi ọwụwa, mgbanwe ọnọdụ obi ugboro ugboro, nsogbu ihi ụra, ịda mba),
akụkụ okuku ume na akpa (ala akọrọ, imi na -ezo, bronchospasm di obere),
usoro nri (dyspepsia, gastralgia, akọrọ mucous akpụkpọ ahụ, pancreatitis, ịba ọcha n'anya na-adịghị adị),
Usoro urinary (ọtụtụ mgbe enwere nkwarụ nke akụrụ)
akpụkpọ (itching, ihe nchapu, isi nkwọcha, psoriasis, sweating ókè, wdg),
allergies n'ụdị urticaria, edema nke Quincke, erythema, ahụ ọkụ na ngosipụta ndị ọzọ.

N’oge na-adịghị anya, enwere mmụba na urea, creatinine, potassium n’ime ọbara.

Mgbe ụfọdụ, mgbe ejiri ya, ike agwụ, hypoglycemia.

Ntụziaka ahụ na-ekewa ihe niile na-adịghị mma nke ọgwụ lisinopril kpatara, ugboro ugboro, na-adịkarị obere.

N'ihe banyere ịdoụbiga ihe ókè, enwere mgbada dị ukwuu, ụkwara, akpịrị akọrọ, nkụda mmụọ, mgbakasị ahụ, iro ụra, iku ume ugboro ugboro, palpitations ma ọ bụ, na nke ahụ, mbelata ya, enweghị mmiri na elektrolytes n'ọbara, ọdịda akụrụngwa, oliguria. Site na ihe ịtụnanya ndị a, nkuzi ahụ na-atụ aro iji ọgwụgwọ ọgwụgwọ Symptomatic.

Omume ọgwụ

ACE inhibitor, na-ebelata nguzobe nke angiotensin II site na angiotensin I. Mbelata nke ọdịnaya nke angiotensin II na-eduga na mbelata nke mbuputara nke aldosterone. Na-ebelata mmebi nke bradykinin ma mee ka njikọ nke Pg dịkwuo elu. Ọ na-ebelata OPSS, ọbara mgbali elu, mbubata, nrụgide n'ime akwara pulmonary, na-akpata mmụba na IOC na ịbawanye nnabata myocardial maka nrụgide na ndị ọrịa nwere nkụda obi. Ọ na-eme ka akwara akwara dị elu karịa akwara. A na-akọwapụta ụfọdụ nsonaazụ site na nsonaazụ sistemụ renin-angiotensin. Site n'iji ogologo oge, hypertrophy nke myocardium na mgbidi nke akwara ndị dị n'ụdị resistive na-ebelata. Ọ na - eme ka ọkpụkpụ ọbara na ischemic myocardium dị mma.

Ndị na - egbochi ACE na-eme ka ogologo ndụ dị ogologo na ndị ọrịa nwere nkụda obi, na-ebelata ọganihu nke LV dysfunction na ndị ọrịa mgbe myocardial infarction na-enweghị ngosipụta ọgwụgwọ nke nkụda obi.

Mmalite nke ọrụ bụ mgbe elekere 1. A na-ekpebi nsonaazụ kachasị mgbe awa 6-7 gachara, oge ahụ bụ awa 24. Site na ọbara mgbali elu, a na-ahụ mmetụta ahụ n’ụbọchị mbụ mgbe mmalite ọgwụgwọ, mmetụta kwụsiri ike na-amalite mgbe ọnwa 1-2 gachara.

Ngwakọta na ụdị ntọhapụ

Otu ọgwụ gụnyere 5 mg, 10 mg na 20 mg nke ihe mejupụtara, nke lisinopril dihydrate na-anọchi anya ya. Ọzọkwa ugbu a:

MCC
Mannitol
Povidone
Mmiri ara ehi
Magnesium Stearic Acid
Calcium hydrogen phosphate
Croscarmellose sodium
Colloidal silicon dioxide.

A na-etinye ọgwụ nke okpukpu kristal na-acha odo odo nke ọdịdị cylindrical. ngwugwu 10 N'ime mkpọ ahụ enwere 2 ma ọ bụ atọ na abụọ. nkwakọ.

Ngwongwo na-agwọ ọrịa

N'okpuru mmetụta nke onye na - egbochi ACE, a na - ahụta mbelata nguzobe nke angiotensin 1 na 2. Site na mbelata nke ego nke angiotensin 2, mbelata ntọhapụ nke aldosterone. Na nke a, mbibi bradykinin na-ebelata, mmepụta nke prostaglandins na-abawanye. Ọgwụ ahụ na-enye aka na mgbochi nke usoro renin-angiotensin-aldosterone. N'ihi nke a, a na-ahụta mbelata ọbara mgbali elu na preload, ngabiga akwara nke mbube na nrụgide dị n'ime okpu ahụ na-ebelata, na ndị mmadụ nwere arụ ọrụ nke CVS, nnwere onwe nke ibu na-abawanye. E gosipụtara mmetụta dị mma nke lisinopril site na mgbasawanye nke akwara.

A na-egosipụta mmetụta antihypertensive 1 awa mgbe ị takingụ ọgwụ, a ruru ọkwa Plasma kachasị elu nke ihe na-arụ ọrụ n'ime awa 7 ma echi ya. Site na ịba ụba ọbara mgbali, a na-edekọ mmetụta ọgwụgwọ nke ụbọchị mbụ nke ọgwụgwọ ọgwụgwọ, a na-enweta mmetụta kwụsie ike na ọnwa 1-2. Ọ bụrụ na mmechu aka na pill ahụ ọgwụ na mberede, ahụghị akara ọbara mgbali elu.

Ọgwụ na-enyere aka belata protein dị na mmamịrị. N'ime ndị nwere akara ịba ụba, a na-achọpụta mwepụta nke ọrụ nke endothelium merụrụ ahụ mara.

Site na ọgwụ ọgwụ Lisinopril Stad ogologo oge, mgbanwe mgbanwe hypertrophic na myocardium, yana ịmegharị ihe na pathologies na CVS, ọrụ endothelium nkịtị na ntinye ọbara na myocardium.

Ọ dị mma ịmara na ndị na - egbochi ACE na-abawanye ndụ mmadụ na ndị nwere ụdị nkụda mmụọ na-adịghị ala ala, na mmụba nke ụsụụ afọ ventricular dysfunction ndị mmadụ tara ahụhụ na myocardial infarction na enweghị akara ọ bụla nke nkụda obi.

A na-ahụta mkpokoro mucosa na eriri afọ na 30%. Mgbe ị na-eri nri, ọ nweghị mbelata n ’ịnwe ọgwụ. Ihe ngosi bioavailability bụ 25-30%.

Edekọtara mmekọrịta nke lisinopril na protein plasma na 5%. Ihe ndị dị n'ọrụ nke mbadamba ọrụ ahụ adịghị agafe na usoro biotransformation n'ime ahụ. Emere mwepụ nke lisinopril n'ụdị nke mbụ ya site na sistemụ akụrụ. Ọkara ọkara bụ ihe dịka awa iri na abụọ. Edekọtara uru nke ihe nwere nnukwu ihe gbasara ezighi ezi akwara.

Lisinopril Stada: ntuziaka zuru ezu maka ojiji

Ọnụahịa: site na 85 ruo 205 rubles.

Ezubere ọgwụ Lisinopril Stada iji ọnụ mee ya.

N'ihe banyere ọbara mgbali elu, a na-enye ha iwu ị drinkụ 5 mg nke ọgwụ otu ugboro n'ụbọchị. Ọ bụrụ na enweghị ọgwụgwọ ọgwụgwọ akpọrọ, ọ ga-ekwe omume ịbawanye usoro onodi ogwu site na 5 mg (ụbọchị 2-3 ọ bụla) ruo mgbe ọkara ogo ọgwụ kwa ụbọchị nke 20-40 mg ruru. N'oge ọgwụgwọ mmezi, a na-atụkwa ọgwụ kwa ụbọchị nke 20 mg. O kwesiri iburu n’obi na ọgwụ kachasị elu kwa ụbọchị ekwesịghị ịfe 40 mg.

Mmetụta ọgwụgwọ na-etolite mgbe izu 2-4 gachara. site na oge mmalite nke ọgwụgwọ, a ga-elebara nke a anya mgbe ị na-abawanye usoro ị drugsụ ọgwụ. Site na ntakịrị nsogbu nke ọgwụgwọ ahụ, enwere ike ịnye ọgwụ ndị ọzọ maka ọgwụ mgbochi ihe.

Nsonaazụ

Site na CCC: mgbali ọbara na-ebelata, arrhythmias, mgbu obi, adịkarịghị - orthostatic hypotension, tachycardia.

Site na sistem ụjọ: akpịrị ọgbụgba, isi ọwụwa, ike ọgwụgwụ, iro ụra, ntanetị akwara nke aka na egbugbere ọnụ, adịkarịghị - asthenia, ike ọgwụgwụ nke ọnọdụ, ọgba aghara.

Site na usoro digestive: ọgbụgbọ, dyspepsia, ọnwụ nke agụụ, mgbanwe uto, ọnya afọ, afọ ọsịsa, akpọnwụ akpọnwụ.

Akụkụ Hematopoietic: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anaemia (agbada Hb, erythrocytopenia).

Mmeghachi omume nfụkasị: angioedema, rashes anụ ahụ, itching.

Usoro Laboratory: hyperkalemia, hyperuricemia, adịkarịghị - ụba ọrụ nke transminases "imeju", hyperbilirubinemia.

Ihe ozo: okpukpo okpomoku, ike nwere obere, odighi akwara gbasara akwara, arthralgia, myalgia, fever, edema (ire, egbugbere onu, aka), isi akwara emeputara.

Ntụziaka pụrụ iche

Achọrọ nlekọta elebara anya mgbe ị na-edegara ndị ọrịa nwere akwara akwara ma ọ bụ stenosis nke akwara akwara akwara (ikekwe mmụba nke urea na creatinine n'ọbara), ndị ọrịa nwere ọrịa obi na-arịa ma ọ bụ ọrịa ụbụrụ, nwere ọrịa obi mgbawa (ike iwere hypotension, myocardial infarction, stroke). N'ime ndị ọrịa nwere nkụchi obi, ọbara ọgbụgba nwere ike ibute arụ ọrụ ezumike.

Mgbe ị na-eji ọgwụ ndị na-ebelata ọbara ọgbụgba na ndị ọrịa nwere nnukwu ịwa ahụ ma ọ bụ n'oge mgbatị ụkwụ, lisinopril nwere ike igbochi guzobe angiotensin nke abụọ, nke abụọ na-ewe iweghachi ihe na-akpata.

Emebeghi nchekwa na arụmọrụ nke lisinopril na ụmụaka.

Tupu ịmalite ọgwụgwọ, ọ dị mkpa iji kwụọ ụgwọ maka ọnwụ nke mmiri na mmiri.

A na - egbochi ọgwụ n'oge ime ime, belụsọ na ọ gaghị ekwe omume iji ọgwụ ndị ọzọ ma ọ bụ na ha anaghị arụ ọrụ (a ga-eme ka onye ọrịa mara banyere ihe egwu nwere ike ibute nwa ebu n’afọ).

Ajuju, azịza, nyocha banyere ọgwụ Lisinopril Stada

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Ndị ọrịa na-enyocha iji ọgwụ ahụ

Emere nyocha nke echiche banyere iji Lisinopril Stada. Nyocha na-achọpụta ma nke ọma ma nke ọjọọ.

N'etiti "pluses", ndị ọrịa kwuru:

arụmọrụ
ụzọ dị mma iji nata
Ezigbo uru maka ego.

E gosipụtara "Cons" dị ka ndị a:

ọnụnọ nke nsonaazụ (nke egosiri na ntuziaka maka ojiji, ụkwara, afọ ọsịsa, obi mgbawa, ọgbụgbọ, isi ọwụwa).
mmetụta ahụ abịaghị ozugbo
na-achọsi ike ịdọrọ diuretic tupu ọgwụgwọ,
dị ize ndụ maka ndị agadi mgbe afọ 65 gasịrị, dị ka ntuziaka ahụ si dị.

Ndi dibia nyocha

Tụlee echiche nke ndị ọkachamara banyere ọgwụ Lisinopril Stada. Nyocha ndị dọkịta kwuru na ọgwụ dị irè, ndị ọrịa na-anabata ya nke ọma.

N'otu oge ahụ, ndị dọkịta chọpụtara na Lisinopril Stada anaghị anagide ya n'onwe ya, ọ dị mkpa iji ọgwụgwọ mgbagwoju anya. O siri ike nyochaa ọnọdụ nke akụrụ, ya bụ, ịtụle ọkwa nke creatinine.

Nsonaazụ nke ọgwụ Lisinopril Stada

Onye na-egbochi ya, ma ọ bụ n'ụzọ ọzọ, onye na-egbochi, 'onye na-egbochi' ACE na-egbochi ịmepụta homonụ angiotensin, nke na-akpasu vasoconstriction na, n'ihi ya, nrụgide dị elu. Na mgbakwunye, angiotensin na-akpata aldosterone homonụ, nke na-egbochi iwepu mmiri n’ahụ. Dị ka ọ na-adịkarị, ọ na - enyere aka iwelie olu ọbara na iwelie mgbali elu, mana oge ụfọdụ ọ na - egosipụta ngosipụta adịghị mma n'ụdị edema, oke mgbali elu na nkụchi obi.

Enwere ike ịhapụ ihe ndị a niile site na ịkwụsịlata oke mmepụta angiotensin n'oge, nke ahụ bụ ihe lisinopril na-eme. Mmetụta ya na-enye aka na mgbasawanye akwara akwara dị ukwuu karịa akwara dị na gburugburu. Ekwesịrị ịtụle nke a mgbe ị na-ejikọ lisinopril na ọgwụ ndị ọzọ.

Ọ bụrụgodị na ị kwụsị ị takingụ ọgwụ na mberede, nsonaazụ ya ga-adịgide ruo oge ụfọdụ: ọ gaghị enwe oke mmụba dị egwu. Site n'iji ogologo oge, lisinopril na-enyere aka weghachite anụ ahụ myocardial nke ischemia emetụta.

Maka ndị nwere nsogbu myocardial infarction na enweghị akara ngosipụta siri ike, nke a pụtara mbelata nke nwayọ nwayọ nke oghere aka ekpe. Maka ndị bi na nkụchi obi na-adịghị ala ala, nke a bụ ohere iji gbatị ndụ ha.

Dodoụbiga ya ókè

Ọ bụrụ na ị gafere ogo ọgwụ ahụ, ihe mgbaàmà ndị a na-egosi:

mbelata nke nrụgide dị n'okpuru 90/60,
akpụkpọ anụ mucous akọrọ, ụkwara,
ụjọ, nchekasị, oke iwe, ma ọ bụ ihe ọzọ - ụjọ ụra,
arụ ọrụ ezumike, urinary retention.

Ọ bụrụ n ’ịnyịfere oke, nke mbụ ịchọrọ iwepu nha anya nke ọgwụ batara n’ime ahụ: hichaa afọ ma were ọgwụ na-anabata ihe. Mgbe ahụ, ọ bụrụ na ọ dị mkpa, ọ dị mkpa iji belata nsonaazụ nke lisinopril: n'ọnọdụ enweghị ike, o zuru ezu iji nyere onye ọrịa ahụ aka ịnya ọnọdụ ma bulie ụkwụ ya elu. Ọ bụrụ na ewerela ọtụtụ ọgwụ ọgwụ, a ga-achọ ọgwụ vasoconstrictor na ngwọta sodium chloride intravenous intraven.

Ọ bụrụ na ọgwụ dị n’ịba oke oke abanyela n’ọbara, a na-enye ya ọgwụ ịba ama.

Ndakọrịta na ọgwụ ndị ọzọ na mmanya

Enwere ike iji Lisinopril mee ihe na mgbochi calcium na mgbochi adrenergic, mana ekwesiri iburu n'uche na a na-eme ka mmetụta nke ọgwụ dịkwuo elu.

Ọ ka mma ịkagbu oriri nke diuretics ma ọ bụ, enwere ike, belata ọgwụ ha. Ọgwụ potassium na-eme ka ọgwụ pụta mgbe ị na-a canụ ike pụrụ ịkpalite hyperkalemia.

Ekwesighi ijikọ Lizonopril Stada na barbiturates, antipsychotics na antidepressants - nrụgide ahụ ga-agbadata n'ụzọ dị egwu.

Medications Tụ ọgwụ maka ọnya afọ na gastritis ga - egbochi nnabata nke lisinopril.

Ojiji nke lisinopril na insulin na hypoglycemic na-eme ka iwe na-akpalite hypoglycemia, karịsịa n'oge ọnwa mbụ nke lisinopril.

Ọgwụ ndị na-egbochi mmebi na-ebelata mmetụta nke ọgwụ ahụ.

Nweghị ike ijikọ ọgwụ ahụ na cytostatics, allopurinol na procainamide iji zere mmepe nke leukopenia.

Ndụ shelf na ọnọdụ nchekwa

Ọgwụ ahụ nwere ike ịnwe njikwa ya ruo afọ atọ, ma ọ bụrụhaala na oge a ọ echekwara ya na ebe gbara ọchịchịrị, na okpomọkụ agaghị akarị ogo 25.

Ekwesighi ịchekwa ọgwụ ahụ ebe ụmụaka nwere ike ịchọta ya, ma were ya mgbe ụbọchị ahụ gwụsịrị.

Ọnụahịa ọgwụ na-adabere na usoro ị theụ ọgwụ yana mpaghara a na-ere ya. Ọnụ ego nke nchịkọta, nke mbadamba iri atọ nke usoro ị aụ ọgwụ nke 5 mg, bụ ihe dịka 110 rubles. Ihe dị ka otu mkpụrụ ego iri abụọ dị mbadamba iri abụọ nwere ọgwụ nke 10 mg. Otu ngwugwu nke nwere mbadamba 20 nke 20 mg na-efu ihe dịka 170 rubles.

Enwere ọtụtụ ọgwụ nwere otu ihe arụ ọrụ nke dị iche na naanị ihe enyemaka yana mba na-emepụta ihe. Ọ bụrụ na ịchọrọ ACE inhibitor nke otu ọzọ, ịkwesịrị ịmụ ọgwụ ike dabere na captopril, zofenopril, benazepril na fosinopril.

Ọ bụrụ na ịchọrọ ọgwụ iji belata nrụgide site na ụdị ọzọ, ị nwere ike ị attentiona ntị na ndị nwere oghere calcium (verapamil, diltiazem) ma ọ bụ ọgwụ antispasmodics (drotaverine na ọgwụ ndị dabere na ya).

Lizonopril Stada - ọgwụ iji belata nrụgide ma melite mgbasa ọbara n'ọkpụkpụ akwara obi. Tupu ịmalite ị theụ ọgwụ, ịkwesịrị ijide n'aka na enweghi ọgwụ mgbochi ma kpọtụrụ dọkịta.

Ihe omuma nke ogwu Lisinopril Stada

Ọbara ọgbụgba, ọnya obi na-adịghị ala ala (dịka ihe mgbakwunye n'ihe gbasara ezighi ike na-enye potassium ma ọ bụ, ọ bụrụ na ọ dị mkpa, yana nkwanye digitalis), nnukwu myocardial infarction ya na usoro ọnụọgụgụ anụ ezi (maka ndị ọrịa nwere paradaịs hemodynamic kwụ ọtọ na SBP karịa 100 mm Hg. Art., Serum creatinine dị n'okpuru 177 μmol / L (2 mg / dL) na proteinuria erughị 500 mg / ụbọchị) na mgbakwunye na usoro ọkọlọtọ nke infarction myocardial, ọkacha mma na nchikota na nitrates.

Ime na lactation

Jiri n'oge ime bụ contraindicated. Tupu ịmalite ọgwụgwọ, ụmụ nwanyị ndị na-amụ nwa kwesịrị ijide n'aka na ha adịghị adị ime. N'oge ọgwụgwọ, ụmụ nwanyị kwesịrị ịme ihe iji gbochie afọ ime. Ọ bụrụ na ịtụrụ ime ka na-eme n’oge ọgwụgwọ, ọ dị mkpa, dịka ndụmọdụ ndị dọkịta si dị, iji dochie ọgwụ ọzọ, ihe na-adịghị njọ maka nwatakịrị ahụ, ebe ọ bụ na iji mbadamba Lisinopril Stada, ọkachasị na ọnwa 6 ikpeazụ nke ịtụrụ ime, nwere ike imerụ nwa ebu n'afọ.

A pụrụ ịpụpụ ndị na - egbochi ACE na mmiri ara ara. A mụọbeghị mmetụta ha na-enye ụmụ ara nyere ụmụ. Yabụ, n'oge ọgwụgwọ ahụ kwesịrị ịkwụsị inye ara.

Usoro onunu ogwu na nhazi

N'ime dị ka iwu, otu ugboro n'ụtụtụ, n'agbanyeghị nri, yana oke mmiri mmiri (dịka ọmụmaatụ, iko mmiri).

Ọbara ọgbụgba: ọnye izizi - 5 mg / ụbọchị, n'ụtụtụ. A na-eme nhọrọ ntụtụ iji nweta ọbara mgbali elu. Emela ka ọnụọgụ ọgwụ dị elu karịa izu 3 gasịrị. Ọtụtụ mgbe, usoro nlekọta ahụ bụ 10-20 mg otu ugboro n'ụbọchị. Anakwere ka ị were ya otu ugboro - 40 mg 1 kwa ụbọchị.

Site na nrụrụ akwara, nkụchi obi, anagide iwepụ diuretic, hypovolemia na / ma ọ bụ nnu (dịka ọmụmaatụ vomiting, afọ ọsịsa ma ọ bụ ọgwụgwọ ọrịa), ọbara ọgbụgba siri ike ma ọ bụ renovascular, yana ndị ọrịa agadi, a na-achọ obere mbido 2.5 mg 1 oge. kwa ụbọchị n'ụtụtụ.

Ọkpụkpụ obi (enwere ike ijikọ ya na nkwadebe na dijitalis): ọgwụ mbụ - 2.5 mg otu ugboro kwa ụtụtụ. A na-ahọrọ dose mmezi ahụ na nkebi, na-abawanye dose site na 2.5 mg. A na-abawanye ọgwụ ahụ nwayọ nwayọ, dabere na nzaghachi nke onye ọrịa. Ọdịiche dị n'etiti mmụba kwesịrị ịdịkarị 2, ọkacha mma izu anọ. Mkpụrụ kachasị maka ya bụ 35 mg.

Nnukwu myocardial infarction na paradaịs hemodynamic kwụsịrị (ekwesịrị ịgụnye ya na nitrates eji, dịka ọmụmaatụ, iv ma ọ bụ n'ụdị akpụkpọ anụ na mgbakwunye na usoro ọgwụgwọ mbụ maka infarction myocardial): a ga-amalite lisinopril n'ime awa 24 mgbe mgbaàmà mbụ ahụ. dabere na usoro hemodynamic kwụsịrị nke onye ọrịa. Usoro izizi bụ 5 mg, mgbe ahụ 5 mg ọzọ mgbe awa 24 na 10 mg gasịrị awa 48, mgbe ahụ na dose 10 mg / ụbọchị. Site na CAD dị ala (mmHg), na ọkwa izizi nke ọgwụgwọ ma ọ bụ na ụbọchị atọ mbụ mgbe nkụchi obi gasịrị, ekwesịrị ịdelata ọgwụ mgashi 2.5 mg.

N'ihe banyere hypotension art art (SBP n'okpuru 100 mmHg), usoro mmezi kwa ụbọchị ekwesịghị gafere 5 mg na, ọ bụrụ na ọ dị mkpa, mbelata 2.5 mg ga-ekwe omume. Ọ bụrụ na, na-agbada mbelata ụbọchị kwa ụbọchị ruo 2.5 mg, hypotension arterial (SBP n'okpuru 90 mm Hg maka ihe karịrị elekere 1), kwụsịrị lisinopril.

Ogologo oge ọgwụgwọ mmezi bụ izu isii. Obere mmezi kwa ụbọchị bụ 5 mg. Site na ihe mgbaàmà nke nkụchi obi, akaghị agwọ ọrịa lisinopril.

Lisinopril dabara na iv concoitant iv ma ọ bụ nchịkwa cutaneous (patches) nke nitroglycerin.

Usoro onunu ogwu maka obere mkpado oruru ndi mmadu (Cl creatinine 30-70 ml / min) na ndi okenye oria (karia iri isii na ise): onwa mbu - 2.5 mg / ubochi, n'ututu, ubara ihe nlebara anya (dabere na njiri ike nke njigide obara) - 5- 10 mg / ụbọchị. Oke kachasị kwa ụbọchị ekwesịghị ịgụta 20 mg.

Iji mee ka nhọrọ nke dose ahụ dị n'otu, mbadamba nkume nke Lisinopril Stada 2.5, 5, 10 na 20 mg nwere akara nkewa (maka ịdị mma nke kewara mbadamba nkume ahụ n'ime akụkụ abụọ ma ọ bụ 4).

Ọ bụ dibia bekee gara kpebie ọgwụgwọ ọ bụla.

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

Lizinopril Stada ọgwụ obi, nke ụlọ ahịa ọgwụ anyị na-enye ịzụta, dị n'ụdị mbadamba ọcha na-enweghị ihe mkpuchi juru na blister plastic, iri n'ime nke ọ bụla. A na-akwakọba blister na ngwugwu kaadiboodu, nke edere aha ọgwụ ahụ, ụbọchị mmepụta, ozi banyere onye nrụpụta, na data ndị ọzọ dị mkpa. Ihe ngwugwu obula nwekwara ntuziaka maka ojiji nke ogwu Lisinopril Stada, nwere ihe omuma ya. Ọnụahịa ọgwụ Lisinopril Stada dabere na ọnụ ọgụgụ mbadamba na ngwugwu - ha nwere ike ịbụ 10, 20, ma ọ bụ 30. Na mgbakwunye, itinye uche na otu mbadamba ihe na-arụ ọrụ, lisinopril, nwere ike ịdị iche. Ọ nwere ike ịbụ 5, 10 na 20 mg, n'otu n'otu. Na weebụsaịtị anyị ị nwere ike ịkọwapụta ọnụnọ nke otu ụdị ma ọ bụ nke ọgwụ ọzọ, hazie nnyefe ụlọ, ma gụọ nyocha na Lisinopril Stada ndị mmadụ jiworo ọgwụ a maka ọgwụgwọ. Na mgbakwunye na lisinopril, ihe mejupụtara ọgwụ a nwere ọgwụ ndị na-esonụ: • mmanya isii-aldite, • Microcrystalline cellulose, • Lactose, • phosphate nke kalsia na-atụgharị, • Nnu magnesium na stearic acid, • Nlekọta ndị ọzọ. Enwere ike ịchọta ihe mejupụtara ya na nchịkọta nke ndị na - emebu ihe site na ịmụ nkọwa nke ọgwụ dị na ntuziaka gọọmentị.

Nchedo nchekwa

Ọgwụgwọ ya na lisinopril maka ọrịa obi na-adịghị ala ala kwesịrị ibido n’ụlọ ọgwụ yana usoro nkwonkwo ya na diuretics ma ọ bụ diuretics na oke ọnụọgụ (dịka ọmụmaatụ, karịa 80 mg nke furosemide), ụkọ mmiri ma ọ bụ nnu (hypovolemia ma ọ bụ hyponatremia: serum sodium erughị 130 mmol / l), ọbara mgbali ala. , nkụda obi na-ekweghị akwụsị akwụsị, ọrụ mkpolatalata, usoro ọgwụgwọ nwere nnukwu vasodilators, onye ọrịa ahụ etoola afọ 70.

Ekwesịrị ilebara ntinye uche nke electrolytes na creatinine n'ọbara ọbara na ihe ndị na-egosi sel ọbara, ọkachasị na mbido ọgwụgwọ na ndị nọ n'ihe ize ndụ (ndị ọrịa nwere ọrịa gbasara akụrụ, ọrịa anụ ahụ), yana iji otu oge immunosuppressants, cytostatics, allopurinol na procainamide.

Nnukwu ọgbụgba. Ọgwụ nwere ike ime ka mbelata ọbara mgbali elu, ọkachasị mgbe ị firstụchara nke mbụ. Symptomatic artpot hypotension na ndị ọrịa nwere ọbara mgbali elu na-enweghị nsogbu dị ụkọ. Ọtụtụ mgbe, ọgbụgbọ na ọgbụgba ọria na - apụta na ndị ọrịa nwere elektrolyte ma ọ bụ ụkọ mmiri, na - anata mmerụ ahụ, na - eso nri nnu dị ntakịrị, mgbe ọ vọsịrị ma ọ bụ afọ ọsịsa, ma ọ bụ mgbe ọ gbasịrị. Achọpụtara hypotension Symptomatic artpot hypotension tumadi na ndị ọrịa nwere ọrịa obi na-adịghị ala ala yana mgbakasị akwara nke na-esite na ya ma ọ bụ na-enweghị ya, yana ndị ọrịa na-anata ọnụọgụ akwara diuretics dị ukwuu na-arịa hyponatremia ma ọ bụ arụ ọrụ na-arụ ọrụ na-arụ ọrụ. N'ime ndị ọrịa dị otú ahụ, ekwesịrị ịmalite ọgwụgwọ n'okpuru nlekọta ahụike siri ike, ọkacha mma n'ụlọ ọgwụ, na obere doses na usoro ọgwụgwọ ahụ kwesịrị iji nlezianya gbanwee. N'otu oge, ọ dị mkpa ileba anya na ọrụ akụrụ yana ọkwa potassium dị mkpa. Ọ bụrụ na ọ ga-ekwe omume, kwusi iji ọgwụ unyi.

Ọ dịkwa mkpa ịkpachara anya na ndị ọrịa nwere ọrịa angina pectoris ma ọ bụ ọrịa cerebrovascular, ebe mbelata ọbara mgbali elu nwere ike ibute infarction ma ọ bụ ọnya afọ.

Ohere nke hypotension Symptomatic artpot n'oge ọgwụgwọ lisinopril nwere ike belata site na kagbuo diuretic ahụ tupu ọgwụgwọ ya na lisinopril.

N'ọnọdụ mmeme ọgbụgba akwara, a ga-edina onye ọrịa ahụ, nye ya ihe ọ drinkụ orụ ma ọ bụ gbanye ya n'akwara ọbara (kwụọ ụgwọ maka mmiri mmiri). Enwere ike ịchọpụta Atropine iji mesoo bradycardia concomitant. Mgbe mwepu nke hypotension akwara nke ọma site na ị doseụ ọgwụ mbụ, ọ dịghị mkpa ịhapụ mmụba na-esote ọgwụ. Ọ bụrụ na hypotension artpot na onye ọrịa nwere obi obi ghọrọ usoro, enwere ike ịbelata belata yana / ma ọ bụ wepu ọgịga na / ma ọ bụ lisinopril. Ọ bụrụ na ọ ga-ekwe mee, ụbọchị 2-3 tupu mmalite ọgwụgwọ na lisinopril, ọgwụgwọ ga-akwụsị ịba ahụ.

Nnukwu ọgbụgba akwara na nnukwu ọrịa myocardial infarction. Na nnukwu myocardial infarction, ọgwụ lisinopril enweghị ike ịmalite ma ọ bụrụ na, maka ọgwụgwọ gara aga na ọgwụ vasodilator, enwere ihe ize ndụ nke njọ njọ nke pọdọd hemodynamic. Nke a metụtara ndị ọrịa nwere CAD nke 100 mm RT. Art. ma n'okpuru ma ọ bụ jiri ujo cardiogenic. Na CAD nke 100 mm RT. Art. na n'okpuru, a ga-agbatị usoro nlekọta ahụ ka 5 mg ma ọ bụ 2.5 mg. Na nnukwu myocardial infarction, ị lụ lisinopril nwere ike ibute nnukwu ọgbụgba akwara. Na hypotension arterial hypotension (SBP erughị 90 mm Hg.maka ihe karịrị elekere 1 h) ọgwụgwọ lisinopril kwesịrị ịkwụsị.

Ndị ọrịa nwere nkụchi obi na-adịghị ala ala mgbe nnukwu nsogbu myocardial infarction, lisinopril kwesịrị ka ewere ya na oke nha hemodynamic kwụ chịm.

Ọrịa ọbara mgbali ọbara / akụrụngwa akwara ọbara (lee "Contraindications"). Site na mgbali umeji renovascular na bilateral (ma ọ bụ na-ejikọ otu akụrụ) stenosis akụrụ, ojiji nke lisinopril nwere ihe ọghọm nke mbelata ọbara mgbali elu na ọdịda akụrụ. Enwere ike ịkawanye ihe egwu a site na iji ọgwụ ndị na - adị ọcha. Ọbụna na ndị ọrịa nwere otu akwara akwara akwara stenosis, ọdịda akụrụ nwere ike ibute naanị obere mgbanwe na serum creatinine. Ya mere, ọgwụgwọ ndị ọrịa dị otú a ga-eme n'ụlọ ọgwụ n'okpuru nlekọta ahụike dị nso, bido site na obere ala, na mmụba ahụ kwesịrị ịdị nwayọ na nlezianya. N'ime izu izizi nke ọgwụgwọ, a ga-akwụsị ọgwụgwọ ọrịa akwara ma nyochaa ọrụ akụrụ.

Renrụ ọrụ na-arụ ọrụ na ụlọ. Jiri nlezianya mee ya na ndị ọrịa nwere ezigbo ọrụ mkpo ya. Ndị ọrịa dị etu a chọrọ obere ọgwụ ma ọ bụ ogologo oge n’etiti usoro onyonyo (lee “Usoro ọgwụgwọ na Nchịkwa”).

Akụkọ banyere mmekọrịta dị n'etiti ọgwụgwọ lisinopril na ọdịda akụrụ metụtara ndị ọrịa nwere nkụchi obi na-adịghị ala ala ma ọ bụ dysfunction mkparịta ụka dị adị (gụnyere akwara renal arten stenosis). Site na nchọpụta oge na ọgwụgwọ kwesịrị ekwesị, ọdịda akụrụ metụtara ọgwụgwọ lisinopril na-abụkarị nlọghachi azụ.

N'ebe ụfọdụ ndị ọrịa nwere ọbara mgbali elu akwara na-enweghị mmerụ akwara doro anya, ọgwụgwọ conisitant na lisinopril na diuretics gosipụtara mmụba na urea ọbara na creatinine. N'ọnọdụ dị otú a, ọ nwere ike ịdị mkpa iji belata ọgwụ mgbochi ACE ma ọ bụ kagbuo diuretic, ị kwesịrị ịtụle ohere enwere ọnya na-arịa ọrịa akwara na-enyochaghị.

Ekwesighi inye ọgwụ ndị ọrịa Lisinopril maka ọrịa myocardial infarction nke nwere mkpịsị ugodi mkpịsị akwara: a serum creatinine over 177 μmol / L (2 mg / dL) na / ma ọ bụ proteinuria karịa 500 mg kwa ụbọchị. Ekwesịrị ịkwụsị Lisinopril ma ọ bụrụ na akụrụ gbasara akwara na-etolite n'oge usoro ọgwụgwọ (enwere ike ikwupụta ọbara ACE Cl creatinine karịa ụmụaka. na-enyochakwa ọbara mgbali na ọrụ akụrụ.

Childrenmụaka. Anaghi aghota odi nma na nchekwa nke lisinopril n’ulo umuaka, ya mere adighi atụ aro nhọpụta ya.

Isi hyperaldosteronism. Na isi aldosteronism, ọgwụ antihypertensive, ihe nke dabere na mgbochi nke usoro renin-angiotensin, anaghị adịkarị mma, ya mere, akwadoghị ojiji nke lisinopril.

Proteinuria Achọpụtala ọnọdụ dị iche iche na mmepe nke proteinuria, ọkachasị ndị ọrịa nwere obere ọrụ mkpo ya ma ọ bụ mgbe ha jisịrị ọgwụ lisinopril zuru oke. Site na proteinuria dị mkpa dị na ụlọ ọgwụ (karịa 1 g / ụbọchị), a ga-eji ọgwụ ahụ naanị mgbe ejiri nlezianya tụlee uru na ọghọm ndị a na-atụ anya ya na iji nlezianya na-elele ụlọ ọgwụ na ụlọ nyocha.

LDL-phoresis / enweghị nchekasị. Commekọ ihe ọnụ na ndị na - egbochi ACE nwere ike ibute mmeghachi omume anaphylactic na-egbu ndụ n'oge phonesis LDL na-eji dextransulfate. Mmeghachi omume ndị a (dịka ọmụmaatụ, mbelata ọbara ọgbụgba, mkpụmkpụ ume, vomiting, mmeghachi ahụ nfụkasị anụ ahụ) na-ekwe omume na nhọpụta nke lisinopril na ndabere nke desensitizing ọgwụgwọ maka ahụhụ nke ahụhụ (dịka ọmụmaatụ, a beesụ ma ọ bụ wasps).

Ọ bụrụ na ọ dị mkpa, LDL-phoresis ma ọ bụ ịtụ ụjọ ọgwụgwọ maka ahụhụ ahụhụ kwesịrị iji ọgwụ ọzọ dochie lisinopril nwa oge (mana ọbụghị ACE inhibitor) maka ọgwụgwọ ọbara mgbali elu ma ọ bụ nkụchi obi.

Ọkpụkpụ anụ / angioedema (lee. "Contraindications"). A na-enwekarị akụkọ banyere angioedema nke ihu, aka, egbugbere ọnụ, ire na nasopharynx n'ime ndị ọrịa mesoro ndị na - egbochi ACE, gụnyere lisinopril. Edema nwere ike itolite n'ọgwụgwọ ọ bụla, nke n'ọnọdụ ndị dị otú ahụ kwesịrị ịkwụsị ozugbo ma nyochaa ọnọdụ onye ọrịa ahụ.

Ọ bụrụ na ọnye oke nwere oke na ihu na egbugbere ọnụ ya, ọ na - apụkarị n'enweghị ọgwụgwọ, ọ bụ ezie na enwere ike iji ọgwụ mgbochi mee ka belata mgbaàmà.

Ihe ọghọm nke ịmalite ọrịa angioedema n'oge ọgwụgwọ ya na ndị na-egbochi ACE dị elu na ndị ọrịa nwere akụkọ banyere angioedema na-ejikọghị ya na iji ndị na-egbochi ACE.

Angioedema nke ire na nasopharynx na - etinye ndụ n'ihe egwu. N'okwu a, a na-egosipụta usoro dị mkpa, gụnyere sc nchịkwa nke 0.3-0.5 mg nke adrenaline ma ọ bụ nchịkwa ivive nke 0.1 mg nke adrenaline mgbe ị na-eleba anya ECG na ọbara mgbali. Ekwesịrị ka ọ gaa ụlọ ọgwụ n'ụlọ ọgwụ. Tupu ịtọhapụ onye ọrịa ahụ ka ekwesịrị idobe awa 12-24, ruo mgbe ihe mgbaàmà niile na-apụ n'anya kpamkpam.

Aortic stenosis / hypertrophic cardiomyopathy. Ekwesịrị iji ndị na-egbochi ACE na-akpachara anya na ndị ọrịa nwere mgbochi nke ọbara na-agbapụta site na ventricle ekpe. Site na mgbochi hemodynamically dị mkpa, lisinopril bụ contraindicated.

Neutropenia / agranulocytosis. Achọpụtala ikpe dịkarịsịrị ọhụrụ nke neutropenia ma ọ bụ agranulocytosis na ndị ọrịa nwere ọbara mgbali elu nke ejiri ọgwụ mgbochi ACE mesoo. A naghị ahụkarị ha na ọbara mgbali elu na-enweghị mgbagha, mana ha na-ahụkarị ebe ndị ọrịa nwere akụrụ gbasara akwara, ọkachasị enwere ọnya anụ ahụ na akwara ma ọ bụ uru akwara (dịka ọmụmaatụ, system lupus erythematosus ma ọ bụ dermatosclerosis) ma ọ bụ jiri otu oge na immunosuppressants. A na-egosi ndị ọrịa dị otú a ileba sel ọcha. Mgbe mwepu nke ndị na - egbochi ACE, neutropenia na agranulocytosis na-apụ n'anya.

N'ihe banyere mmụba nke ahụ anụ ahụ, mmụba nke oghere lymph na / ma ọ bụ akpịrị mgbu n'oge ọgwụgwọ, ị kwesịrị ịkpọtụrụ dọkịta ozugbo wee chọpụta mkpokọta mkpụrụ ndụ ọbara ọcha n'ime ọbara.

Wa ahụ ịwa ahụ / ọgwụ na - egbu azụ. N'ime ndị ọrịa a na-awa ahụ tara akpụ ma na-anata ọgwụ na-agbatị ọgwụ mgbu na-ebelata ọgwụ mgbochi, lisinopril na-egbochi guzobe nke angiotensin II n'ihi mmachi nke renin. Ọ bụrụ na hypotension akwara pụta n'ihi nke a, enwere ike idozigharị ya site na itinyeghachi mmiri mmiri (lee “Mmekọrịta”).

N'ọnọdụ oke ọbara ọgbụgba ma ọ bụ ọrịa obi na-adịghị ala ala, ịmalite ọgwụgwọ, yana mgbanwe ọgwụ, ekwesịrị ịme ụlọ ọgwụ.

N'ihe banyere ị theụ ọgwụ ahụ n ’ọgwụ dị ka ọgwụ e kenyere gị ma ọ bụ na-amị amị, ọ̀ bụ ihe a na-anabataghị okpukpu abụọ nke usoro a. Naanị dọkịta nwere ike ịbawanye ọgwụ ahụ.

N'ọnọdụ nkwụsịtụ nwa oge ma ọ bụ ịkwụsị usoro ọgwụgwọ na ndị ọrịa nwere nkụda mmụọ, mgbaàmà nwere ike ịmalite. Akwụsịla ọgwụgwọ na-agwaghị dọkịta.

Enweghị ọmụmụ ihe banyere ọgwụ a na ike ịkwọ ụgbọala. Agbanyeghị, mmadụ kwesịrị iburu n'uche ikike ịnya ya n'ụgbọala na usoro, yana ịrụ ọrụ n'enweghị nkwado ntụkwasị obi ọ bụla n'ihi ọgbụgbọ na ike ọgwụgwụ.

Mkparịta ụka ọgwụ ọjọọ

Enwere ozi banyere mmekọrịta nke ọgwụ Lisinopril Stada na ọgwụ ndị ọzọ: • Iji nkwonkwo mee ya na-akpali mmetụta nke iwetula ọbara mgbali elu, ọbụna na-egosi ihe dị ize ndụ maka ahụike. Ọ bụrụ na ọ ga-ekwe omume, ekwesịrị ịkpa oke tupu ọgwụgwọ ya. • utionkpachara anya, should ga-a lụ mmiri nke lisinopril na ụzọ ọ bụla nwere potassium, n'ihi na nke a nwere ike ime ka itinye uche ya niile n'ahụ, Stad, yabụ, a ga-enyocha akara a n'oge usoro ọgwụgwọ. • Nkwadebe maka ọgwụgwọ nke obi mgbawa na ọrịa ndị ọzọ na-adabere na acid nke eriri afọ, belata nnabata nke ihe na-arụ ọrụ. Colestyramine nwere mmetụta yiri ya. • Nchịkọta njikọ nke lisinopril na insulin na ndị ọzọ na-egbochi ọgwụ nwere ike belata njupụta nke glucose na ọbara ruo 3.5 mmol / L, nke a na-ahụta ka ọrịa. • Ojiji nke ọgwụ mgbu, ọgwụ antipyretic nke ọgwụ na - abụghị steroid, na - enyere aka ịnagide ọkụ na usoro mkpali, belata ịdị irè nke lisinopril n'ihe banyere iweda ọbara mgbali elu. • Ọgwụ ndị nwere ọla edo eji na ọgwụgwọ nke ọrịa rheumatoid ogbu na nkwonkwo nwere ike, mgbe ewere ya na lisinopril, nwere ike ime ka arịa ọbara jupụta na ihu, ọbara ọbara nke anụ ahụ, vomiting, ọgbụgbọ. • Cytostatic, ọgwụ antiarrhythmic, xanthine oxidase inhibitors, mgbe ejikọtara ya na lisinopril, nwere ike ibute mbelata nke mkpụrụ ndụ ọbara ọcha. • A nabatara ojiji ọgwụ a jikọtara ya na ọgwụ ndị na-eme ka mgbochi nke betoadrenoreceptors, ọgwụ nitrate, ọgwụ na-enyere aka ịlụ ọgụ nke oke ọbara. • Mgbe ejiri acid acetylsalicylic acid, ọnụọgụ nke ikpeazụ kwesịrị ịnwe oke, iji gbochie mbelata ịdị irè nke ọgwụgwọ. Usoro akwadoro nke acetylsalicylic acid abụghị ihe karịrị 300 mg kwa ụbọchị.

Usoro na ọnọdụ nchekwa

Chekwaa ogwu ebe a na echebe ya na mmiri. Oge a na-atụ aro nchekwa nchekwa anaghị gafere ogo 25 Celsius. Ekwela ka ụmụaka ghara iru ya. Ndụ nchekwa nke ọgwụ Lisinopril Stada bụ afọ atọ site na ụbọchị emepụtara egosipụtara na ngwugwu ahụ. N'ọnọdụ mmebi, a machibidoro ị takeụ ọgwụ ahụ - ọ ga-adị mkpa ka ewepu ya iji lekọta usoro ndị dị mkpa anya.