Etu esi eji ọgwụ Glukovans mee ihe? > Ọgwụgwọ na mgbochi

Sdị usoro nke Glucovans - mbadamba nkume: biconvex ekpuchishịrị n'ime fim gbara agba nke agba agba mmanụ na-ese ya n'otu akụkụ nke "2.5" ma ọ bụ agba odo na-enwe ihe osise "5" (PC 15. Na blisters, na ngwungwu kaadiboodu nke blisters abụọ).

Glibenclamide - 2.5 mg ma ọ bụ 5 mg,
Metformin hydrochloride - 500 mg.

Ndị pụrụ iche: povidone K30, sodium croscarmellose, magnesium stearate, cellulose microcrystalline.

Ihe mejupụtara shei ahụ bụ oroma / odo edo edo: opadry OY-L-24808 pink / opadry 31-F-22700 odo (hypromellose 15cP, lactose monohydrate, titanium dioxide, iron oxide red, iron oxide black / dye quinoline odo, macrogol, iron oxide edo edo), mmiri dị ọcha.

Mlọ ọgwụ

Glucovans bụ ngwongwo abụọ nke ọgwụ hypoglycemic nke na-eme ọnụ, nke dị iche iche nke ọgwụ ọgwụ: glibenclamide na metformin.

Metformin bụ akụkụ nke ìgwè biguanide ma belata ọkwa nke ma ọ bụ postprandial na glual na plasma ọbara. Ọ bụghị ihe na - eme ka insulin na-akpali akpali, nke na-akpata ntakịrị ihe ize ndụ nke hypoglycemia. Uzo ato nke ime ihe bu ihe ejiri mara ha:

igbochi nnabata glucose na ngha,
na-abawanye uche nke ndị na - anabata insulin na - anabata ya, na - amụba oriri na ojiji nke glucose site na mkpụrụ ndụ akwara.
mbelata nke njikọ glucose n'ime imeju site na mgbochi nke glycogenolysis na gluconeogenesis.

Metformin metụtakwara akwara nke ọbara, na-ebelata ịta nke triglycerides, obere lipoproteins dị ala (LDL) na cholesterol zuru oke.

Glibenclamide bụ usoro nke abụọ sitere na sulfonylurea. A na-ebelata ọkwa glucose mgbe a na-abanye ihe a na-arụ ọrụ ike n'ihi mmegharị nke mmepụta insulin site na mkpụrụ ndụ beta dị na pancreas.

Ofzọ usoro nke metformin na glibenclamide dị iche iche, mana ihe ndị ahụ nwere mmetụta synergistic ma nwee ike ịkwalite ọrụ hypoglycemic nke ibe ha, nke na-enye ohere iji belata nnukwu glucose ọbara.

Mlọ ọgwụ

Nwepu nke glibenclamide site na akwara gbasara eriri afọ mgbe nchịkwa ọnụ gafere 95%. Ngwaọrụ a na - arụ ọrụ nke Glucovans bụ micronized. Oke ihe a na-etinye na ihe dị na plasma ruru ihe ruru awa anọ, olu nke nkesa ya dị ihe dịka 10 lita. Glibenclamide na-ejikọ protein protein plasma site na 99%. Ọ bụ ihe fọrọ nke nta ka ọ bụrụ 100 metabolized n'ime imeju, na-akpụ metabolites abụọ na-adịghị arụ ọrụ, bụ nke a na-agbanye na bile (60% nke ọgwụ a na-ewe) na mmamịrị (40% nke ọgwụ a na-ewere). Iwepu ọkara ndụ dị iche na awa anọ ruo awa iri na otu.

Mgbe nchịkwa ọnụ gasịrị, a na-amịkọrọ metformin site na eriri afọ, zuru oke, ọkwa Plasma kachasi ruru n'ime awa 2.5. Ihe dị ka 20-30% nke ihe ahụ dị na ọnya diges na-agbanweghi agbanwe. Ezigbo bioavailability bụ 50-60%.

A na-ekesa Metformin na anụ ahụ n'ọsọ dị elu, ogo ya na-ejikọkwa na protein ndị dị na plasma pere mpe. A na-agwakọta ngwa ahụ n’ime obere akwara. Iwepu ọkara nke ndụ bụ ọkara awa 6.5. N'ime ndị ọrịa nwere akụrụngwa akwara, enwere mbelata mmụba akụrụ na mmụba na ọkara ndụ, nke a na - eduga n'ịbawanye ụba nke metformin na plasma ọbara.

Nchikota nke glibenclamide na metformin na otu ọgwụ bu otu bioavailability si di ka mgbe ị na-ewere mpempe mbadamba ihe ndi nwere ihe ndia n’eme iche. Nri adighi emetuta bioavailability nke Glucovans, nke bu ngwakọta nke glibenclamide na metformin. Agbanyeghị, ọnụego nnabata nke glibenclamide mgbe eji nri na-abawanye.

Ihe ngosi maka ojiji

Dịka ntuziaka ahụ si dị, Edere Glucovans maka ndị okenye nwere ọrịa shuga 2 ọ bụrụ:

Otutu ogwu omumu mbu nwere sulfonylureas ma obu metformin, usoro nri na mmega aru adighi ike,
Ejikọtara ọgwụgwọ yana usoro ọgwụgwọ metformin na sulfonylurea na ndị ọrịa nwere glycemia na-achịkwa nke kwụsiri ike kwesịrị iji dochie anya monotherapy.

Ihe ngbanwe

Ọrịa shuga 1dị 1
Ọrịa mamịrị precca na coma
Ọrịa mamịrị ketoacidosis
Lactic acidosis, tinyere akụkọ ihe mere eme nke
Ahụhụ na / ma ọ bụ imeju akwara,
Mmebi ọgbaghara arụrụala (nsụpụta okike (QC))
Ọnọdụ ọjọọ na-akpata mgbanwe na ọrụ akụrụ: ọrịa dị ukwuu, akpịrị ịkpọ nkụ, ujo, iodine intravascular nwere ihe ndị na - egosi ọdịiche,
Ọrịa ọgbụgba
Azụ hypoxia dị n'ihu nke nnukwu akụkụ okuku ume ma ọ bụ nkụda mmụọ, oke ure, myocardial infarction,
Oge ime na inye nwa ara,
Ihe a na-ejikarị miconazole,
Nnukwu ịwa ahụ
Mmanya na-egbu egbu, mmanya na-egbu egbu,
Nnabata na nri hypocaloric (ihe na-erughị 1000 kcal kwa ụbọchị),
Ọrịa glucose-galactose malabsorption syndrome, ịkpa ókè galactose, ụkọ lactase,
N’agbata afọ 18
Afọ karịrị afọ iri isii, mgbe ị na-arụ nnukwu arụ ọrụ (ihe ize ndụ nke lactic acidosis),
Akpachapụ anya na akụkụ nke ọgwụ ahụ ma ọ bụ ihe ndị ọzọ na-eme ka sulfonylurea.

N'iji nlezianya mee, a na-akwado Glucovans maka: ọrịa nke gland ahụ gland na mmebi nke ọrụ ya, enweghi nsogbu, ọrịa febrile, hypofunction nke akụkụ ahụ.

Ntụziaka maka ojiji nke Glucovans: usoro na usoro onunu ogwu

A na-atụ aro mbadamba Glucovans ka ha were nri, a ga-etinyekwa akwa carbohydrates na nri.

Dọkịta depụtara ọgwụ ahụ otu otu, na-eburu n'uche ogo nke glycemia.

Ọgwụ nke mbụ bụ 1 mbadamba abụọ Glucovans 2.5 mg / 500 mg ma ọ bụ Glucovans 5 mg / 500 mg otu ugboro n'ụbọchị.

Mgbe ị na-ebufe onye ọrịa na ngwakọta ma ọ bụ monotherapy na sulfonylurea na metformin na ọgwụgwọ Glucovans, iji gbochie hypoglycemia, usoro mbụ ekwesịghị ịgabiga nha kwa ụbọchị nke ọgwụ ndị ị takenụbu. Iji nweta nchịkwa kwesịrị ekwesị nke glucose ọbara, a kwesịrị ịbawanye dose ahụ nwayọ, ọ gaghị karịa 5 mg / 500 mg kwa ụbọchị kwa izu abụọ ma ọ bụ obere. Mgbanwe dose kwesịrị ịdị mgbe ọ bụla dabere na ọkwa nke glycemia.

Oke kachasị kwa ụbọchị bụ mbadamba 4 Glucovans 5 mg / 500 mg ma ọ bụ mbadamba 6,5 mg / 500 mg. A na-ekpebi usoro nke mbadamba ụrọ n'otu n'otu, ọ dabere na ọgwụ kwa ụbọchị:

1 mbadamba (nke usoro ọ bụla) - 1 oge kwa ụbọchị, n'ụtụtụ,
2 ma ọ bụ mbadamba 4 (usoro ọ bụla) - ugboro 2 n'ụbọchị, n'ụtụtụ na mgbede,
3, 5 ma ọ bụ 6 mbadamba 2.5 mg / 500 mg ma ọ bụ mbadamba 3 nke 5 mg / 500 mg - ugboro 3 kwa ụbọchị, kwesịrị iwere ya n'ụtụtụ, n'ehihie na mgbede.

Maka ndị ọrịa agadi, ọgwụ izizi ekwesịghị ịfe 1 mbadamba 2.5 mg / 500 mg. Ekwesịrị inyocha ebumnuche nke ọgwụ na ojiji nke Glucovans mgbe niile maka ọrụ ezumike.

Nsonaazụ

Site na nri digestive: ọtụtụ mgbe - enweghị agụụ, ọgbụgbọ, mgbu afọ, vomiting, afọ ọsịsa. Ihe mgbaàmà na-egosipụtakarị na mmalite ọgwụgwọ ma ọ bụ nwa oge. Ọ dịkarịsịrị ike - nsogbu nke imeju, ịba ọcha n'anya,
Site na anụ ahụ anụ ahụ: ọtụtụ mgbe - uto nke metal n’ọnụ. Na mbido usoro ọgwụgwọ, enwere ike ịlele anya nwa oge,
Site n'akụkụ nke metabolism: hypoglycemia, adịkarịghị - mwakpo nke anụ porphyria na imeju porphyria, ọ dịkarịsịrị - lactic acidosis. Site na usoro ọgwụgwọ ogologo oge - mbelata ogo ọkwa nke vitamin B12 n'ọbara ọbara (nwere ike ibute ọgbụgba megaloblastic). Na-emegide ihe ọ consumptionụ alcoholụ na-aba n'anya dị ka mmeghachi omume dishamfiram.
Ahụhụ Hematopoietic: adịkarịghị - thrombocytopenia na leukopenia, ọ dịkarịsịrị ike - pancytopenia, hemolytic anaemia, ụkwara ọkpụkpụ, akrisulocytosis,
Na akpụkpọ anụ ahụ: ọ na - adịkarịghị - itching, akpịrị dị ka ọnya, ọ na - adịkarịghị - exfoliative dermatitis, erythema multiforme, photoensitivity,
Mmeghachi omume nfụkasị: adịkarịghị - urticaria, adịkarịghị - visceral ma ọ bụ vasculitis nfụkasị anụ ahụ, ujo anaphylactic. Site na nchịkwa nke imekọ ihe ọnụ, ị nwere ike ịfefe hyia na sulfonamides na usoro ha ga-ekwe omume,
Ngosiputa ihe nlere: Imeghari ohuru - mmụba na ịta nke creatinine na urea n'ọbara ọbara ruo ogo dị oke ala, ọ dịkarịsịrị ike - hyponatremia.

Dodoụbiga ya ókè

Ludoụbiga ókè nke Glucovans nwere ike ịkpalite mmepe nke hypoglycemia, ebe ọ bụ na ụdị ọgwụ sulfonylurea bụ akụkụ nke ọgwụ.

A na-edozi mgbaàmà nke hypoglycemia dị nwayọ ruo obere oge na enweghị nsogbu nke usoro ụjọ ahụ na syncope na-abụkarị mmezi shuga. Shouldkwesịrị ịhazigharị usoro Glucovans yana / ma ọ bụ gbanwee nri. Ọ bụrụ na ndị ọrịa na-arịa ọrịa shuga mellitus na-enwe mmeghachi omume hypoglycemic siri ike, yana paroxysm, coma ma ọ bụ nkwarụ ndị ọzọ, a ga-enyerịrị nlekọta ahụike mberede. Ozugbo emerela nchọpụta ọrịa ma ọ bụ ntakịrị enyo nke hypoglycemia, a na-atụ aro nchịkwa ngwa ngwa nke usoro dextrose tupu etinye onye ọrịa n'ụlọ ọgwụ. Mgbe onye ọrịa nwetasịrị onwe ya, ekwesịrị inye ya nri nwere carbohydrates, nke a na-anabata ngwa ngwa, nke ga-egbochi ịmalite ịmalite hypoglycemia.

Ogologo oge nchịkwa nke ndị Glucovans na oke ọnụọgụ ma ọ bụ ihe ndị dị ize ndụ nwere ike iduga mmepe nke lactic acidosis, ebe ọ bụ na metformin bụ akụkụ nke ọgwụ ahụ. A na-ahụta acidosis acid dị ka ọnọdụ chọrọ nlekọta ahụike mberede, na ọgwụgwọ ya kwesịrị ịrụ naanị na ụlọ ọgwụ. Ofzọ kachasị dị mma nke ọgwụgwọ na-akwalite mkpali nke lactate na metformin gụnyere hemodialysis.

N'ime ndị ọrịa nwere ọrịa imeju, mkpochapu nke glibenclamide na plasma ọbara nwere ike ịba ụba. Ebe ọ bụ na ihe a na - eme na protein na plasma nke ukwuu, enwere ike iwepụ ya n'oge a na - agwọ ọrịa ọbara.

Ntụziaka pụrụ iche

A na-atụ aro ka ọgwụgwọ gbakwunye ya na nleba anya oge niile nke glucose ọbara na-ebu ọnụ yana mgbe ị gachara nri.

N'oge nchịkwa nke Glucovans, ọ dị mkpa iburu n'uche ohere nke ịmalite lactic acidosis, ihe ịrịba ama nke ọrịa ahụ nwere ike ịbụ ọdịdị nke mgbu afọ, oke ịrịa, nkwonkwo akwara na nkwarụ dyspeptik.

Mgbe ị na-etinye ndị Glucovans, enwere ihe ize ndụ nke ịmalite hypoglycemia, o yikarịrị ka ọ na-eme ndị ọrịa na nri nwere carbohydrate dị ala, na-esoghị nri, na-a alcoholụ mmanya, na-enweta mgbatị ahụ siri ike na nri hypocaloric. Cakpachara anya na idepụta, ịhọrọ nlezianya nke ị andụ ọgwụ na ntinye nke ndụmọdụ nke dọkịta na-ebelata ohere ọrịa.

A machibidoro ị drinkụ mmanya n'oge ọgwụgwọ.

Tupu nhọpụta nke ndị Glucovans na n'oge nchịkwa, ekwesịrị ịme ọmụmụ ihe oge niile iji chọpụta ọkwa nke itinye uche serin creatinine. Ekwesịrị ịme nyocha ahụ na ndị ọrịa nwere ọrụ mkpo nkịtị, ọ dịkarịa ala 1 oge kwa afọ, yana nkwarụ akụrụ na ndị ọrịa agadi na-arụ ọrụ - ugboro 2-4 kwa afọ.

Ọ bụrụ na ọrịa na-efe efe nke bronchi, ngụgụ, ma ọ bụ akụkụ urogenital pụtara, kpọtụrụ dọkịta ozugbo.

Ime na lactation

Mmalite nke ime bụ ihe mgbochi maka iji glucovans. Ekwesịrị ịgwa ndị ọrịa na oge ọgwụgwọ ọgwụ ahụ ha kwesịrị ịgwa dọkịta banyere nhazi nke ịtụrụ ime ma ọ bụ mmalite ya. N'ime ihe abụọ a, a na-akagbu Glucovans ozugbo a na-enye usoro ọgwụgwọ insulin.

Enweghị ozi banyere ike nke metformin na njikọ glibenclamide ịbanye na mmiri ara, ya mere, ịnabata ọgwụ ahụ n'oge a na-enye nwa ara anabataghị.

Jiri na agadi

A na-ehiwe usoro maka ndị ọrịa merela agadi na-eburu n'uche ọnọdụ ọrụ gbasara akụrụ, nke a ga-enyocha ya mgbe niile. Usoro izizi n’ebe ndị ọrịa nọ n’otu ụdị bụ 1 mbadamba 2.5 mg / 500 mg.

A naghị atụ aro iji Glucovans na ndị ọrịa nke afọ ha karịa afọ 60 ma bụrụ ndị agbasichara mgbatị anụ ahụ, nke a na-akọwara site n'ihe ize ndụ dị elu nke ịmalite lactic acidosis na ha.

Mkparịta ụka ọgwụ ọjọọ

Ekwesịrị ịkwụsị nchịkwa Glucovans ụbọchị 2 tupu ma maliteghachi ụbọchị 2 mgbe nchịkwa ọbara nke iodine nwere ihe dị iche.

Amachibidoro iji miconazole n'otu oge ahụ, n'ihi nnukwu ohere nke ịmalite hypoglycemia, ruo coma.

Agaghị atụkọta ọgwụ a na ọgwụ ethanol nwere ọgwụ na phenylbutazone, ebe ọ bụ na ha na-abawanye ike hypoglycemic nke Glucovans.

N'iji bosentan mee ihe n'otu oge, ihe ize ndụ nke ime ihe hepatotoxic na-abawanye, mmetụta nke glibenclamide na-ebelata.

Nnukwu chlorpromazine dị ukwuu na-ebelata mwepụta insulin, na-eme ka mmụba nke glycemia.

Mmetụta hypoglycemic nke Glucovans na-ebelata mgbe ejikọtara ya na glucocorticosteroids, tetracosactide, diuretics, danazol na beta2-adrenergic agonists.

Mgbe ị na - ewere antioxensin-converting enzyme (ACE) ndị na - egbochi, gụnyere enalapril na captopril, enwere mbelata ọbara glucose ọbara.

Njikọ ya na metformin chọrọ nlekọta pụrụ iche na ndị ọrịa nwere nsogbu gbasara akụrụngwa arụrụala, ebe ọ bụ na ohere nke ịmalite lactic acidosis dị elu na iji “loop” diuretics.

Nchikota nke ndi Glucovans na sympathomimetik, beta-egbochi, reserpine, clonidine, guanethidine na-ezochi ihe ngosi nke hypoglycemia.

Imezi dose dị mkpa mgbe ị na-ewere fluconazole, enwere ihe ize ndụ nke hypoglycemia.

Glibenclamide na-ebelata mmetụta antidiuretic nke desmopressin.

Mmetụta hypoglycemic nke ndị Glucovans na-abawanye site na iji otu oge na monoamine oxidase inhibitors (MAOs), sulfonamides, anticoagulants (coeriarineri), fluoroquinolones, chloramphenicol, pentoxifylline, ọgwụ ndị na-eme ka ọ dị nfe site na otu nke fibrates, nnupụisi.

Ihe analogues nke Glucovans bu: Glybomet, Glukonorm, Glyukofast, Bagomet Plus, Metformin, Siofor.

Nyocha Glucovans

Ndị ọrịa nwere ọrịa shuga na-ahapụ nyocha Glucovans n'ịntanetị. Ọtụtụ mgbe ha na-ekwu maka okwu metụtara ịhọrọ ọgwụ na usoro ọgwụgwọ, yana njikwa ya na ọgwụ ndị ọzọ. Agbanyeghị, nyocha ndị ahụ n'onwe ha bụ arụrịta ụka. Nkwupụta ndị ahụ kwuru na iji rụpụta nsonaazụ kachasị n'oge ọgwụgwọ, ọ dị mkpa ịgụta ọnụ ọgụgụ kalori na oriri na-egbu carbohydrate, ma nyochaa nlezianya nlele nke usoro ọgwụ.

Agbanyeghị, enwere echiche ndị na-abaghị uru nke Glucovans. Ndị ọrịa na-eme mkpesa na enweghi mmelite na ọdịmma yana ihe ndị dị iche site na uru nkịtị nke ịta shuga n'ọbara (hypoglycemia). Ndị ọrịa ndị ọzọ na-akọ na iji wee mezie ahụike ha, ha ga-agbaso ogologo ntụzi nke usoro ọgwụgwọ na ụdị ndụ ha.

Releasedị Glucovans tọhapụrụ, nchịkọta ọgwụ na ihe mejupụtara.

A na-eji mbadamba ụrọ na-acha uhie uhie, nke a kapịrị ọnụ, biconvex kpuchie mbadamba nkume ndị ahụ, na ihe osise "2.5" n'otu akụkụ.

Taabụ 1
metformin hydrochloride
500 mg
glibenclamide
2,5 mg

Ndị na-ahụ maka ihe: povidone K30, magnesium stearate, sodium croscarmellose, microcrystalline cellulose, Opadry (Opadri) OY-L-24808, mmiri dị ọcha.

15 PC. - blisters (2) - igbe kaadiboodu.
20 nkp. - blisters (3) - igbe kaadiboodu.

Mbadamba ụrọ a na-acha odo odo bụ okpu mkpuchi, biconvex, nke nwere "5" a na-etinye akụkụ n'otu akụkụ.

Taabụ 1
metformin hydrochloride
500 mg
glibenclamide
5 mg

Ndị na-ahụ maka ihe: povidone K30, magnesium stearate, sodium croscarmellose, microcrystalline cellulose, Opadry (Opadri) 31F22700, mmiri dị ọcha.

15 PC. - blisters (2) - igbe kaadiboodu.
20 nkp. - blisters (3) - igbe kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Pharmacological edinam Glucovans

Ngwakọta ọgwụ hypoglycemic ejikọtara ọnụ maka iji ọnụ mee ihe.

Glucovans bụ ngwongwo abụọ nke ọgwụ hypoglycemic nke otu ọgwụ dị iche iche.

Metformin bụ otu nke biguanides ma belata ọbara ọgbụgba site na ịbawanyewanye uru anụ ahụ na-eme ka insulin dịkwuo elu ma mee ka mgbakwunye glucose dị elu. Metformin na -ebe ike ịmịnye carbohydrates site na ngari nri ma gbochie gluconeogenesis na imeju. Ọ nwekwara mmetụta bara uru na ngwakọta nke ọbara, na-ebelata ọkwa cholesterol zuru oke, LDL na TG.

Glibenclamide na-ezo aka n'ụkpụrụ nke sulfonylurea nke ọgbọ nke abụọ. Ọkwa glucose mgbe ị na-a gụ glibenclamide na-ebelata n'ihi mkpali nke insulin na -akpata site na mkpụrụ ndụ nke akwara.

Usoro onunu ogwu na uzo icho ogwu a.

Mkpebi ọgwụ a ka dọkịta kpebiri n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ọkpụkpụ glycemia.

Dị ka ọ dị, usoro izizi nke Glucovans bụ taabụ 1. 500 mg / 2.5 mg kwa ụbọchị. Mgbe ị na-eji metformin na glibenclamide dochie usoro ọgwụgwọ agakọ gara aga, a na-enye mbadamba 1-2. Glucovansa 500 mg / 2.5 mg dabere na ọkwa gara aga. Kwa izu 1-2 mgbe mmalite nke ọgwụgwọ, a na-edozi dose ahụ dabere na ọkwa nke glycemia.

E kwesịrị iji nri dị mbadamba.

Oke kachasị kwa ụbọchị bụ mbadamba 4. Glucovansa 500 mg / 2.5 mg ma ọ bụ taabụ 2. Glucovansa 500 mg / 5 mg.

Mmetụta dị n'akụkụ Glucovans:

Site na usoro digestive: na mmalite ọgwụgwọ, ọgbụgbọ, ọgbụgbọ, mgbu nke afọ, ọnwụ nke agụụ nwere ike ime (n'ọtụtụ oge, gafee onwe gị na ịchọghị ọgwụgwọ pụrụ iche, iji gbochie mmepe nke mgbaàmà ndị a, a na-atụ aro ị theụ ọgwụ ahụ na 2 ma ọ bụ 3, usoro mbata nke ọgwụ ahụ na-emekwa ka ndidi ya dịkwuo mma, ikekwe, ihe ụtọ sitere na “ọnụ” n'ọnụ.

Ndị ọzọ: erythema, megaloblastic anaemia, lactic acidosis.

Site na usoro digestive: ọgbụgbọ, ọgbụgbọ, ihe mgbu epigastric, ụba ọrụ nke enzymes imeju.

Site na usoro hemopoietic: leukopenia, thrombocytopenia, adịkarịghị - agranulocytosis, hemolytic anaemia, pancytopenia.

Mmeghachi omume nfụkasị: - urticaria, ihe ọnya afọ, itching akpụkpọ.

Ndị ọzọ: hypoglycemia, disulfiram dị ka mmeghachi omume mgbe ị na-a alcoholụ mmanya.

Ntụziaka pụrụ iche maka ojiji nke Glucovans.

N'oge ọgwụgwọ ya na ndị Glucovans, ọ dị mkpa ileba anya n'ogo glucose dị n'ọbara na afọ na-enweghị nri na mgbe ị risịrị nri.

Ekwesịrị ịdọ onye ọrịa aka na ntị ma ọ bụrụ na ọgbụgbọ na mgbu mgbu na-esochi ọnya olu ma ọ bụ ọrịa ịba na-apụta n'oge ọgwụgwọ Glucovans, mgbe ahụ, a ga-akwụsị ọgwụ ahụ ị kwesịrị ịkpọtụrụ dọkịta ozugbo, ebe ọ bụ na mgbaàmà ndị a nwere ike ịbụ ihe ịrịba ama nke lactic acidosis.

Onye ọrịa ahụ kwesịrị ịgwa dọkịta banyere mpụta ọrịa bronchopulmonary ma ọ bụ ọrịa urinary tract.

Oge awa 48 tupu ịwa ahụ ma ọ bụ nchịkwa nke ihe na-akpata rediopaque nwere ayodiin, a ga-akwụsị glucovans. A na-atụ aro ịmaliteghachi ọgwụgwọ Glucovans mgbe awa 48 gachara.

N'oge ọgwụgwọ, a naghị atụ aro ị drinkụ mmanya.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

N'oge a na-emeso Glucovans, mmadụ ekwesịghị itinye aka na ọrụ ndị chọrọ ịbawanye ụba nke nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Mmekọrịta Glucovans na ọgwụ ndị ọzọ.

Ọgwụ ndị na-akwalite Glucovans (ohere dị ukwuu nke hypoglycemia)

Site na iji Glucovans na-emekọ ihe ọnụ, miconazole nwere ike ịkpasu mmepe nke hypoglycemia (ruo mmepe nke coma).

Fluconazole na-abawanye ihe T1 / 2 nke ihe nchịkwa sulfonylurea ma nwekwuo ohere nke mmeghachi omume hypoglycemic.

Mmanya na-egbu egbu na-eme ka ihe ndị a na-eme na hypoglycemic mmeghachi omume (ruo na mmepe nke coma). N'oge ọgwụgwọ ya na ndị Glucovans, a ga-ezere mmanya na ọgwụ nwere ethanol (mmanya).

Ojiji nke ACE inhibitors (captopril, enalapril) na-eme ka ohere nke ịmalite hypoglycemic mmeghachi omume na ndị ọrịa nwere ọrịa mellitus na ọgwụgwọ nke usoro sulfonylurea site na iwelie ndidi glucose na ibelata mkpa nke insulin.

Ndị na-egbochi ihe dị iche iche na - eme ka ịbawanye ụba nke hypoglycemia ọgụ. Ndị na-egbochi Beta na-egbochi ihe ngosipụta nke hypoglycemia dị ka palpitations na tachycardia.

Ọgwụ nke na-ebelata mmetụta nke glucovans

Danazole nwere mmetụta hyperglycemic. Ọ bụrụ na ọgwụgwọ maka Danazol dị mkpa na mgbe a kwụsịrị nke abụọ, a ga-achọ ndozi nke Glucovans n'okpuru njikwa glycemia.

Chlorpromazine na usoro onunu ogwu dị elu (100 mg / ụbọchị) na-akpata mmụba nke glycemia.

GCS na-abawanye glycemia ma nwee ike iduga mmepe nke ketoacidosis.

Beta2-adrenostimulants na-abawanye ọkwa nke glycemia n'ihi mkpali nke ndị na-anabata 2-adrenergic.

Diuretics (ọkachasị “loopbacks”) na-akpalite mmepe nke ketoacidosis n'ihi mmepe nke ọdịda akụrụngwa nke arụrụala.

Na / na ntinye nke iodine nwere ihe dị iche na - elekọta mmadụ nwere ike ime ka mmepe nke ọdịda akụrụ, nke ga - eduga na nchịkọta nke ọgwụ na ahụ na mmepe nke lactic acidosis.

Ndị na-egbochi Beta na-egbochi ihe ngosipụta nke hypoglycemia, dị ka palpitations na tachycardia.

Usoro onunu ogwu na nhazi

Emere mbadamba ihe ndị dị na Glucovans maka nchịkwa ọnụ. A na-ewere mbadamba n'oge nri, nke kwesịrị inwe nnukwu carbohydrates, iji gbochie hypoglycemia.

A na-ahọpụta usoro ị attendingụ ọgwụ ahụ site na dọkịta na-aga ya.

Usoro mbu nke Glucovans bụ 1 mbadamba (2.5 mg + 500 mg ma ọ bụ 5 mg + 500 mg) otu ugboro n'ụbọchị. A na-atụ aro ka iwelie dose ahụ kwa izu abụọ ma ọ bụ karịa site na karịa 500 mg nke metformin na 5 mg nke glibenclamide kwa ụbọchị iji nwee ike ijikwa ọkwa glucose ọbara nke ọma.

Mgbe ị na-eji glibenclamide na metformin dochie usoro ọgwụgwọ gara aga, ọgwụ izizi ekwesịghị ịdị elu karịa usoro glibenclamide na metformin nke e buru ụzọ. Kwa izu abụọ mgbe ịmalite ọgwụgwọ, usoro ị ofụ ọgwụ na-edozi.

Ogo kachasị nke Glucovans kwa ụbọchị bụ mbadamba 4 5 mg + 500 mg ma ọ bụ mbadamba 6,5 mg + 500 mg.

Usoro usoro onunu ogwu:

Mgbe ị na-edepụta otu mbadamba ụbọchị kwa ụbọchị - n'ụtụtụ, n'ụtụtụ,
Site na nhọpụta nke 2, 4 mbadamba kwa ụbọchị - n'ụtụtụ na anyasị,
Site na nhọpụta mbadamba 3, 5, 6 kwa ụbọchị - n'ụtụtụ, ehihie na mgbede.

Mpempe usoro onunu ogwu

500 mg / 2.5 mg na 500 mg / 5 mg mbadamba ihe nkiri

Cna-apụ

Usoro onunu ogwu 500 mg / 2.5 mg

Otu mbadamba ihe

bekee arụ ọrụ: metformin hydrochloride 500 mg

glibenclamide 2.5 mg,

ndị mbụ: sodium croscarmellose, povidone K 30, cellulose microcrystalline, magnesium stearate

ihe mejupụtara ihe ngosi ihe nkiri Opadry OY-L-24808 bụ pink: lactose monohydrate, hypromellose 15cP, macrogol, titanium dioxide E 171, iron oxide odo E 172, iron oxide red E 172, iron oxide black E 172.

Usoro onunu ogwu 500 mg / 5 mg

Otu mbadamba ihe

bekee arụ ọrụ: metformin hydrochloride 500 mg

glibenclamide 5 mg

ndị mbụ: sodium croscarmellose, povidone K 30, cellulose microcrystalline, magnesium stearate

ihe mejupụtara nke ihe nkiri Opadry 31-F-22700 bụ odo: lactose monohydrate, hypromellose 15 cP, macrogol, quinoline odo varnish E 104, titanium dioxide E 171, iron oxide odo E 172, iron oxide red E 172.

Usoro onunu ogwu 500 mg / 2.5 mg: mbadamba nkume nwere iberibe ihe nkiri na-acha odo odo, okpu mkpuchi nwere akụkụ biconvex na kanye “2.5” n'otu akụkụ.

Usoro onunu ogwu 500 mg / 5 mg: Mbadamba ụrọ nwere ihe mkpuchi odo na-acha odo odo, okpu mkpuchi nwere ọdịdị biconvex na-egosi "5" n'otu akụkụ.

Ngwongwo ogwu

Mlọ ọgwụ

Metformin na Glibenclamide

Bioavailability nke metformin na glibenclamide na njikọta na bioavailability nke metformin na glibenclamide mgbe a na-ewere ha n'otu oge n'ụdị nkwadebe monocomponent. Nri adighi emetuta bioavailability nke metformin yana ijikota glibenclamide, tinyere bioavailability nke glibenclamide na metformin. Agbanyeghị, ogo oriri glibenclamide na-abawanye site na nri ị na-eri.

Mgbe nchịkwa ọnụ nke mbadamba metformin, a na-enweta mkpokọta plasma kachasị (Cmax) mgbe ihe dị ka awa 2.5 (Tmax) gasịrị. Ndụ ahụ zuru oke na ahụike bụ 50-60%. Mgbe nchịkwa ọnụ gasịrị, 20-30% nke metformin na-apụ apụ site na eriri afọ na-agbanwe agbanwe.

Mgbe ị na-eji metformin mee ihe na usoro ọgwụgwọ oge mbụ yana ụdị nchịkwa, a na-enweta ntinye plasma mgbe niile n'ime awa iri anọ na anọ na iri anọ na anọ, ọ kacha erughị 1 /g / ml

Ogo ogo nke metformin na protein plasma bụ nke a na-eleghara anya. A na-ekesa Metformin n’ime sel ọbara. Oke kachasị n'ọbara dị ala karịa na plasma ma erute ya n'otu oge. Nkezi olu nke nkesa (Vd) bụ lita 63–276.

Metformin na-agbanwegharị na mmamịrị. Onweghi ihe metxtin metabolites n’ahụ mmadụ.

Mkpochapu akwara nke metformin karịrị 400 ml / min, nke na-egosi mkpochapu metformin site na iji mkpo na ngwakọta tubular. Mgbe nchịkwa ọnụ gasịrị, ọkara ndụ ahụ bụ ihe dịka awa 6.5.

N'ihe banyere ọrụ akụrụ na-emebi emebi, mkpochapu akwara na-agbadata n'ike n'ike, site na iwepụta ọkara ndụ, nke a na-ebute mmụba nke ọkwa plasma metformin.

Mgbe ejiri hazie, nnabata si eriri afọ bụ ihe karịrị 95%. A na-enweta mkpo plasma kachasị elu mgbe awa anọ gachara. Nkwukọrịta na protein protein bụ 99%.

A na-emegharị Glibenclamide n'ime imeju kpamkpam iji mepụta metabolites abụọ.

E wepụrụ Glibenclamide kpamkpam site n’arụ mgbe ọ dị awa iri anọ na anọ ruo iri anọ na anọ ruo iri anọ na anọ (4%) na mmamịrị (40%). Oge ndụ ọkara ikpeazụ bụ awa 4-11.

Ọrịa ịba ọcha n'anya na-ebelata metabolism nke glibenclamide ma belata ngwa ngwa.

Egwu biliary nke metabolites na-abawanye n'ihe gbasara akụrụ gbasara akwara (ọ dabere n'ịdị arụ ọrụ akwara ọrụ) na ọkwa 30m / min. Yabụ, ọdịda akụrụ anaghị emetụta mpụta nke glibenclamide, ebe iwepu creatinine na-anọ n'ọkwa dị elu karịa 30 ml / min.

Pharmacokinetics na otu ọrịa ndị pụrụiche:

Ọrịa ụmụaka

Enweghị ọdịiche dị iche iche na ọgwụ ọgwụ nke metformin na glibenclamide na ụmụaka na ndị okenye siri ike.

Mlọ ọgwụ

Metformin bụ biguanide nwere mmetụta antihyperglycemic, nke na-ebelata ọkwa glucose abụọ na basal na postprandial. Ọ naghị akpali insulin n'ahụ ya mere ọ naghị ebute hypoglycemia.

Metformin nwere usoro 3 dị iche iche:

na-ebelata mmepụta glucose imeju site na igbochi gluconeogenesis na glycogenolysis,

na-eme ka mmelite na ojiji nke glucose na-emegharị ahụ na akwara dị elu site na ịba ụba nke insulin,

na-egbu oge ịmịkọta glucose na eriri afọ.

Metformin na-akpali njikọ nke glycogen njikọ intracellular site n'ime ihe na glycogen synthase. Ọ na - eme ka ikike nke ndị na - ebugharị glucose dị iche iche (GLUT) mee ka ikike dịkwuo elu.

N'agbanyeghị mmetụta ọ na glycemia, metformin nwere mmetụta dị mma na metabolism lipid. N'oge ule nke ụlọ ọgwụ a na-achịkwa site na iji usoro ọgwụgwọ, a chọpụtara na metformin na-ebelata cholesterol dị ala, njupụta dị ntakịrị na triglycerides. Achọpụtaghị mmetụta ndị a na metabolism lipid n'oge ule nke ụlọ ọgwụ site na iji usoro ọgwụgwọ na metformin na glibenclamide.

Glibenclamide bụ otu nke sulfonylureas ọgbọ nke abụọ nwere ọkara ọkara ndụ. Glibenclamide na-ebute mbelata ọbara, na-akpali mmepụta nke insulin site na pancreas. Ihe omume a dabere na ọnụnọ β-sel nke na-arụ ọrụ nke agwaetiti nke Langerhans.

Nkpali nke mmiri insulin site na glibenclamide na nzaghachi nri nri di nkpa.

Ojiji nke glibenclamide na ndị ọrịa na-arịa ọrịa shuga na-akpata mmụba na nzaghachi insulin na-akpali akpali. Mmeghachi omume postprandial dịkwuo mma n'ụdị zoro ezo nke insulin na C-peptide na-adịgide ọ dịkarịa ala ọnwa 6 mgbe ọgwụgwọ gasịrị.

Metformin na glibenclamide nwere usoro ọrụ dị iche iche, mana jikọtara onwe ha ọnụ na ọrụ antihyperglycemic. Glibenclamide na-akpali mmepụta nke insulin site na pancreas, na metformin na-ebelata nguzo nke sel na insulin site na ime ihe na mpaghara (akwara akwara) na imeju insulin.

Usoro onunu ogwu na nhazi

Ekwesịrị iji okwu Glucovans® nweta nri. A na-agbanwe usoro nke ọgwụ ahụ dabere na nri otu onye. Iri nri ọ bụla nwere carbohydrate kwesịrị ịgbakwunye ya, iji gbochie ọrịa hypoglycemia.

Uzo ogwu a gha gha emeghari dabere na nzaghachi nke metabolic nke mmadu (ogo nke glycemia, HbA1c).

Enwere ike iji Glucovans 500 mg / 5 mg karịa na ndị ọrịa na-enwebeghị ike nchịkwa zuru oke mgbe ha na-ewere Glucovans 500 mg / 2.5 mg.

Ọgwụgwọ kwesịrị ibido site na iji ọgwụ a jikọtara ọnụ ya na usoro ọgwụgwọ metformin na glibenclamide emeburu. Okwesiri ịbawanye dose ahụ nwayọ nwayọ dabere na ọkwa nke glycemic parameters.

A na-edozi ọgwụ ahụ kwa izu abụọ ma ọ bụ karịa site na mmụba nke mbadamba 1, dabere na ọkwa nke glycemia.

Mmụba nke ị doseụ ọgwụ nwayọọ nwayọọ nwere ike inye aka belata nnabata afọ ma gbochie mmepe nke hypoglycemia.

Maximumgwọ kachasị kwa ụbọchị maka Glucovans® 500 / 2.5 bụ mbadamba 6.

Maximumgwọ kachasị kwa ụbọchị maka Glucovans® 500/5 mg bụ mbadamba 3.

N'ọnọdụ ndị pụrụ iche, enwere ike ịtụ aro maka mmụba nke ihe ruru 4 mbadamba ọgwụ ọgwụ Glucovans® 500 mg / 5 mg kwa ụbọchị.

Maka usoro onunu ogwu Glucovans® 500 mg / 2.5 mg

Otu ugboro n'ụbọchị: n'ụtụtụ n'oge nri ụtụtụ, na-edobe 1 mbadamba kwa ụbọchị.

Ugboro abụọ n'ụbọchị: n'ụtụtụ ma na mgbede, na -emeghe mbadamba 2 ma ọ bụ 4 kwa ụbọchị.

Ugboro atọ n'ụbọchị: n'ụtụtụ, n'ehihie na mgbede, na-enwe mbadamba 3, 5 ma ọ bụ 6 kwa ụbọchị.

Maka usoro onunu ogwu Glucovans® 500 mg / 5 mg

Otu ugboro n'ụbọchị: n'ụtụtụ n'oge nri ụtụtụ, na-edobe 1 mbadamba kwa ụbọchị.

Ugboro abụọ n'ụbọchị: n'ụtụtụ ma na mgbede, na -emeghe mbadamba 2 ma ọ bụ 4 kwa ụbọchị.

Ugboro atọ n'ụbọchị: n'ụtụtụ, n'ehihie na mgbede, na-enwe mbadamba mbadamba 3 kwa ụbọchị.

Enweghị data maka iji ọgwụ ahụ insulin.

Ka ị na-ewere Glucovans® na chele bile, a na-atụ aro ka ịwere Glucovans® ọbụlagodi awa anọ tupu onye na-agụ akwụkwọ ọgụgụ gị iji belata ohere belata mmụcha.

Ntuziaka usoro ọgwụgwọ pụrụ iche maka otu ndị ọrịa ọrịa akọwapụtara

Ndị okenye na ndị okenye maara ọrụ

O kwesiri idoghari onodu nke Glucovans® dabere na udu nke akwara. Ọgwụ nke mbụ bụ mbadamba 1 nke Glucovans® 500 mg / 2.5 mg. Ntụle oge niile maka ọrụ gbasara akụrụ dị mkpa.