Otu esi eji Lorista ND maka ọrịa shuga

Ngwakọta nke Lorista nọ n'ọrụ bụ losartan, nke nwere ikike igbochi nnabata angiotensin 2 na obi, akụrụ, arịa ọbara, na adrenal cortex, nke na-eduga na mbelata vasoconstriction (warara nke lumen nke akwara akwara), mbelata nke nguzogide oke na, n'ihi ya, mbelata obara obara.

N'ihe banyere nkụda mmụọ obi Lorista, nyocha ndị ahụ na-egosi na ọ na-eme ka ntachi obi nke ndị ọrịa nwere mgbatị anụ ahụ, na-egbochi mmepe nke hypertrophy nke myocardial. Enwere ike ịhụ ntinye uche kachasị na losartan n'ime ọbara 1 awa mgbe nchịkwa ọnụ nke Lorista, ebe metabolites guzobere na imeju na-amalite ime ihe mgbe awa 2.5-4 gasịrị.

Lorista N na Lorista ND bụ ngwakọta nke ọgwụ, ihe ndị dị n'ime ha bụ losartan na hydrochlorothiazide. Hydrochlorothiazide nwere mmetụta diuretic akpọrọ, nke a bụ n'ihi ike nke ihe ahụ iji metụta usoro nke usoro nke abụọ nke urination, nke bụ reabsorption (absorption) nke mmiri, magnesium, potassium, chlorine, sodium ion, yana oge ọ na-egbu oge ịpụ uric acid na calcium ion. Hydrochlorothiazide nwere ngwongwo hypotensive, nke a na-akọwa ya site na ihe o mere iji gbasaa arterioles.

Enwere ike ịhụ mmetụta mmetụta nke ihe a n'ime awa 1-2 mgbe etinyere nke Lorista N, ebe mmetụta hypotensive na-etolite n'ime ụbọchị 3-4.

Ihe ngosi Lorista

Ntụziaka ahụ na-atụ aro ị ofụ ọgwụ Lorista mgbe:

ọbara mgbali ike
ọbara mgbali elu aka ekpe na ọbara mgbali elu iji belata nsogbu ọnya afọ,
ọrịa obi na-adịghị ala ala, dị ka akụkụ nke ọgwụgwọ njikọta.
nephrology n'ime ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 2 iji belata protenuria (ọnụnọ protein na mmamịrị).

Dịka ntuziaka ahụ si dị, a ka edobere Lorista N ma ọ bụrụ na ọ dị mkpa, ọgwụgwọ ejikọtara ya na ọgwụ mgbochi na diuretics.

Ihe ngbanwe

Lorista, ngwa a gụnyere ndụmọdụ ahụike tupu oge eruo, edeghị ya maka ọbara ọgbụgba dị ala, akpịrị ịkpọ nkụ, hyperkalemia, enweghị ntachi obi, glucose na-arịa ọrịa galactose syndrome, hyperensitivity losartan. Kwesịrị ịhapụ ojiji nke ndị ọrịa ime na ndị na-enye nwa ara Lorista, yana ndị nọ n'okpuru afọ 18. Lorista N, na mgbakwunye na contraindications ndị dị n'elu, edeghị ya maka nnukwu akwara nwere nnukwu nsogbu ma ọ bụ ọrụ hepatic na anuria (enweghị mmamịrị na eriri afo).

Iji kpachara anya, ekwesịrị iburu mbadamba mkpụrụ osisi Lorista na ndị nwere mkpịsị akwara ma ọ bụ ọrịa ịba ọcha n'anya, yana mmiri mmiri electrolyte nwere nsogbu, na-ebelata oke ọbara na-ekesa.

Ntụziaka maka iji Lorista

Lorista dị n'ụdị mbadamba nwere 100, 50, 25 ma ọ bụ 12.5 mg nke potassium losartan. Ekwesịrị ị oụ ọgwụ ahụ otu ugboro n'ụbọchị.

N'ihe banyere ọbara ọgbụgba akwara, iji belata nsogbu ọnya afọ, yana ichekwa akụrụ na ndị ọrịa nwere ọrịa mellitus, a na-atụ aro mbadamba nkume Lorista ị were mbadamba Lorista kwa ụbọchị nke 50 mg. Ọ bụrụ na ọ dị mkpa, iji rụpụta nsonaazụ pụtakwuo, enwere ike ịbawanye ọnụọgụ ahụ ruo 100 mg kwa ụbọchị. Dabere na nyocha, Lorista na-etolite mmetụta antihypertensive n'ime izu 3-6 nke ọgwụgwọ. Site na nchịkwa nke oge a na -eme oke ọgwụ diuretics, iji Lorista kwesịrị ịmalite na 25 mg kwa ụbọchị. Ọzọkwa, a na-atụ aro obere ọgwụ maka ndị nwere ọrụ imeju na-adịghị mma.

N'ihe banyere ezughi oke, ọgwụ Lorista, ngwa ahụ na-agụnye ijikọ oge nke diuretics na cardiac glycosides, a na-eji ya dịka otu atụmatụ si dị. N'ime izu izizi nke ọgwụgwọ, Lorista kwesịrị ị takeụ ọgwụ 12.5 mg kwa ụbọchị, mgbe ahụ kwa izu, a ga-agbatịkwu ọgwụ kwa ụbọchị site na 12.5 mg. Ọ bụrụ na ewere ọgwụ ahụ n'ụzọ ziri ezi, a ga-amalite izu nke anọ nke ọgwụgwọ site na 50 mg nke Lorista kwa ụbọchị. Ekwesiri iji usoro ọgwụgwọ nke Lorista gaa n'ihu na iji usoro nlekọta nke 50 mg.

Lorista N bụ mbadamba nkume nwere 50 mg nke losartan na 12.5 mg nke hydrochlorothiazide.

Mbadamba ọgwụ Lorista ND nwere otu ngwakọta nke ihe, naanị ugboro abụọ - 100 mg nke losartan na 25 mg nke hydrochlorothiazide.

Site na mgbali ọbara, a na-anabata mbadamba ọgwụ kwa ụbọchị nke Lorista N bụ 1 mbadamba, ọ bụrụ na ọ dị mkpa, a na-anabata mbadamba 2 kwa ụbọchị. Ọ bụrụ na onye ọrịa nwere mbelata oke olu ọbara na-ekesa, ekwesịrị ịmalite ọgwụ a kwa ụbọchị nke 25 mg. Ekwesịrị ị were mbadamba mkpụrụ ndụ Lorista N mgbe itusichara olu nke ọbara ekesasịsịrị mmadụ na nhichapụ nke ndị na - adị ọcha.

Dabere na nyocha, ọ dị mma iwere Lorista N n'ihe ize ndụ nke ọrịa obi ma ọ bụrụ na losartan monotherapy enyereghị aka iru ọkwa mgbali ọbara. Usoro ọgwụ a tụrụ aro ya kwa ụbọchị bụ mbadamba 1-2.

Nsonaazụ

Nsonaazụ nke mbadamba ụrọ Lorista na ọnwụnwa ọgwụgwọ gụnyere:

isi ọwụwa, nsogbu ehighị ụra, ike ọgwụgwụ, dizzness, asthenia, nsogbu ụbụrụ, oke ụjọ, migraine, ịda mba,
dose-based hypotension, bradycardia, tachycardia, palpitations, angina pectoris, arrhythmia, vasculitis,
ngwo, ụkwara, pharyngitis, mkpọchi imi ma ọ bụ ọzịza, mkpụmkpụ ume,
mgbu afọ, afọ ọsịsa, ọgbụgbọ, akpịrị akọrọ, anorexia, gastritis, flatulence, afọ ntachi, ọgbụgbọ, eze mgbu, ọrụ imeju na-arịa, ịba ọcha n'anya,
ọrịa urinary na-efe efe, urination a na-achịkwaghị achịkwa, ọrụ na-arụ ọrụ na-arụ ọrụ abawanye ụba, ụba serum creatinine na urea,
ọgbụgba na-ebelata inwe mmekọahụ, enweghi ike,
mgbu na azụ, ụkwụ, obi, cramps, olu mgbu, ogbu na nkwonkwo, ogbu na nkwonkwo,
conjunctivitis, nkwarụ anya, ihe na-enye mmadụ nsogbu, tinnitus,
erythema (ọbara ọbara nke anụ ahụ, na-akpasu iwe site na mgbasawanye nke capillaries), ịba ụba ọsụsọ, akpụkpọ akọrọ, phytosensitization (ịba ụba nke radieshon ultraviolet), oke ntutu,
gout, hyperkalemia, anaemia,
angioedema, ihe ngbua nke aru, itching, urticaria.

Dịka iwu, mmetụta edepụtara na ọgwụ ọjọọ Lorista nwere obere oge na adịghị ike.

Mmetụta Lorista N nwere nke ọma n'ọtụtụ ụzọ yiri mmeghachi omume nke nsụzụ anụ ahụ na ntinye nke Lorista.

Ime na lactation

Arịa ọrịa na - efe efe maka ihe egwu teratogenicity mgbe ị na - ewere ndị na - egbochi ACE na ọkara mbụ nke afọ ime anaghị ekwe ka okwu mmechi ikpeazụ, mana anaghị enwe mmụba dị ntakịrị n'ihe ize ndụ. N'agbanyeghị eziokwu ahụ bụ na enweghị data ọrịa na-achịkwa nke teratogenicity nke ARA-I, a gaghị apụtaghị ihe ize ndụ yiri ya na otu ọgwụ. Ọ gwụla ma ọ bụrụ na ọ gaghị ekwe omume iji ọgwụ ndị ọzọ dochie ARA-I, ndị ọrịa na-eme atụmatụ ịtụrụ ime tụgharịrị na ọgwụ ọgwụ, ebe a ghọtara profaịlụ nchekwa nke ụmụ nwanyị dị ime. Mgbe ime dị, ARA-I kwesịrị ịkwụsị ozugbo, ọ bụrụ na ọ dị mkpa, ekwesịrị ịde ọgwụ ndị ọzọ. Site na iji ARA-I na nkebi nke abụọ na nke atọ nke afọ ime, a na-egosipụta ngosipụta nke fetotoxic utịp (arụ ọrụ ezughi oke ọrụ, oligohydroamniosis, igbu oge ossification nke ọkpụkpụ isi) na nsonye obi na-egbu egbu (akwara renal, hypotension, hyperkalemia). Ọ bụrụ na enyere APA-II n’oge nke abụọ ma ọ bụ nke atọ nke ịtụrụ ime, a na-atụ aro ka ọ rụọ ọrụ nyocha nke akụrụ na ọkpụkpụ isi ya. N'ime ụmụ amụrụ ọhụrụ, ndị nne ya buru ARAL, ọ dị mkpa iji nlezianya nyochaa ọbara ọbara iji gbochie mmepe nwere ike ịmalite.

Ozi gbasara ojiji nke hydrochlorothiazide n'oge afọ ime nwere oke, ọkachasị maka ọnwa atọ. Hydrochlorothiazide na-agafe Plasenta. Dabere na usoro nke ọgwụ pharmacological, enwere ike ịrụ ụka na ojiji ọ dị na nke abụọ na nke atọ nke afọ ime nwere ike ịkpaghasị isi placental ma kpata nsogbu nwa ebu n’afọ na nwa amụrụ, dị ka jaundice, electrolyte anọgighị ala na thrombocytopenia. Ekwesighi iji Hydrochlorothiazide maka ọrịa gestational edema, ọbara mgbatị ahụ ma ọ bụ toxicosis nke afọ ime n'ihi ohere nke mbelata olu nke plasma na mmepe nke hypoperfusion placental na enweghị mmetụta dị mma n'ọrịa ahụ.

Ekwesighi iji Hydrochlorothiazide na-agwọ ọbara ọgbụgba ọbara nke ụmụ nwanyị dị ime, ma e wezụga ọrịa ndị ahụ dịkarịsịrị mgbe ị na-achọ ọgwụgwọ ọzọ agaghị ekwe omume.

Onweghi data banyere iji ọgwụ Lorista ND n’oge ị breastụ ara. Ekwesịrị inye usoro ọgwụgwọ ọzọ ka ejiri ọgwụ nke egosipụtara nke ọma na nchekwa nchekwa n'oge a na-enye nwa ara, ọkachasị mgbe ị na-enye ụmụ amụrụ ọhụrụ ma ọ bụ ụmụ agafebeghị.

Usoro onunu ogwu na nhazi

A na-ahapụ ọgwụ a ka o jiri ọgwụ ndị ọzọ na - egbochi ihe ọnụ.

Enwere ike ị drugụ ọgwụ ahụ n'agbanyeghị nri.

Ikwesiri iji iko mmiri were techie mbadamba nkume a.

Nmekorita nke losartan na hydrochlorothiazide maka ọgwụgwọ mbu, a na-atụ aro iji ya n'ọnọdụ enweghị nchịkwa zuru oke nke ọbara mgbali iji losartan etinyere na hydrochlorothiazide. A na-atụ aro ntinye akụrụngwa nke doses. Ọ bụrụ n’ịkpa ụlọ ọgwụ, ọ dị mma ịtụle ntụgharị site na monotherapy ka ojiji nke ijikọtara ya na oke ọnụọgụ.

Ọgwụ mmezi a na-eme bụ 1 mbadamba Lorista N (losartan 50 mg / hydrochlorothiazide 12.5 mg) otu ugboro n'ụbọchị.

Site na nzaghachi ọgwụgwọ ezughi oke, enwere ike ịbawanye dose ahụ gaa na mbadamba 1 nke Lorista ND (losartan 100 mg / hydrochlorothiazide 25 mg) otu ugboro n'ụbọchị. Oke kachasị bụ 1 mbadamba Lorista ND (losartan 100 mg / hydrochlorothiazide 25 mg) kwa ụbọchị.

Dịka iwu, a na-enweta mmetụta hypotensive n'ime izu 3-4 mgbe mmalite ọgwụgwọ.

Jiri maka ezughi oke ọrụ gbasara akụrụngwa yana ndị ọrịa n'ọrịa akụrụngwa N'ime ndị ọrịa nwere nnukwu akụrụ akwara na-achịkwa (mwepụ nke creatinine nke 30-50 ml / min), a chọghị ịgbanwe ọgwụ mbụ. A naghị atụ aro ya ka etinye akwụkwọ maka nchikota a maka ọrụ ezumike mkpirisi (mwepu nke mkpụrụ osisi)

Dodoụbiga ya ókè

Ozi a kapịrị ọnụ banyere ngbanwe nke Losartan 50 mg / Hydrochlorothiazide

12.5 mg adịghị.

Ọgwụgwọ a bụ Symptomatic, na-akwado.

Ọ bụrụ n ’ịdoụbiga ọgwụ ike ókè, a ga-akwụsị ị drugụ ọgwụ, a ga-ebufe onye ọrịa ka ọ na-elebara ya anya. Ọ bụrụ na ewere ọgwụ a n'oge na - adịbeghị anya, a na - atụ aro ka ọ kpalite ọgbụgbọ, yana iji ụzọ ndị ama ama iji mepụta ihe mgbochi iji wepu oke mmiri, enweghị isi, mmiri ọkụ na hypotension.

Dodoụbiga data ókè nwere oke. O kwere omume, o yikarịrị ka ihe ịrịba ama: hypotension, tachycardia, bradycardia (n'ihi mkpali mkpali). Mgbe hypotension hypotension mere, a ga-enyerịrị usoro ọgwụgwọ mmezi.

Ma losartan ma ọ bụ metabolite na-arụ ọrụ ya enweghị ike ịpụpụ site na usoro ọgwụgwọ metụtara anụ ahụ.

Ihe nrịba ama a na-ahụkarị, "hypokalemia, hypochloremia, hyponatremia (nke kpatara mbelata nke electrolyte) na akpịrị ịkpọ nkụ (n'ihi oke ịba ọcha). Ọ bụrụ na edepụtara digitalis n'otu oge, hypokalemia nwere ike ibute iwe nke obi arrhythmia.

Ego ole hydrochlorothiazide na-anyụpụta n'oge a na-amakọghị amata.

Mmekọrịta na ọgwụ ndị ọzọ

Rifampicin na fluconazole na-ebelata itinye uche nke metabolite na-arụ ọrụ. Achoghi ihe banyere ogwu site na nmekorita a.

Dị ka ọ dị n'ihe banyere ọgwụ ndị ọzọ na-egbochi angiotensin II ma ọ bụ belata mmetụta ya, ojiji a na-ejikọta potassium-sparing diuretics (spironolactone, triamteren, amiloride), yana mgbakwunye potassium na ntụgharị nnu nwere ike iduga mmụba na mkpokọta potassium na plasma ọbara. A naghị atụ aro iji otu ọgwụ ndị a n'otu oge.

Dị ka ọgwụ ọjọọ ndị ọzọ na-emetụta ihe ngosi sodium si dị, losartan nwere ike belata mwepu nke lithium n'ahụ ahụ. Ya mere, n'iji sal APA-II na salts salts, mmadụ kwesịrị iji nlezianya nyochaa ọkwa nke ikpeazụ na plasma ọbara.

Site na iji APA-II na ọgwụ mgbochi na - abụghị steroidal anti-inflammatory ọgwụ (NSAIDs) (dịka ọmụmaatụ, cyclooxygenase-2 inhibitors (COX-2), acetylsalicylic acid na ọgwụ mgbochi mkpali na NSAIDs na-adịghị ahọrọ), enwere ike ịda mbà na hypotensive. ARnweta ARA-I ma ọ bụ ọgwụ ndị nwere NSAID nwere ike ịbawanye n'ihe ọghọm nke ọrụ ezumike, gụnyere ọdịda akụrụ oke, ma bute mmụba na mkpokọta plasma potassium (ọkachasị ndị ọrịa nwere ọrụ mgbazinye na-adịghị ala ala). Ekwesịrị iji nlezianya mee ihe nchikota a, karịsịa na ndị agadi. Ndị ọrịa kwesịrị ịnata mmiri kwesịrị ekwesị, kwesịkwara ịtụle nlezianya arụ ọrụ akụrụ mgbe mmalite nke ọgwụgwọ concomitant na oge ụfọdụ n'oge ọgwụgwọ.

Na ụfọdụ ndị ọrịa nwere nsogbu gbasara akụrụngwa arụ ọrụ, gụnyere. Ndị na-egbochi COX-2, iji ya eme ihe APA-II nwere ike ibute mmetụ ọrụ ezumike. Agbanyeghị, mmetụta a na-atụgharịghachi kpamkpam.

Ọgwụ ndị ọzọ nwere mmetụta hypotensive bụ ọgwụ tricyclic antidepressants, ọgwụ antipsychotic, baclofen na amifostine. Lojikọ ọnụ nke losartan na ọgwụ ndị a na - ebute nsogbu hypotension.

Site na ojiji nke thiazide diuretics na ọgwụ ndị na-esochi, enwere ike ịhụ mmekorita.

Etaniol, barbiturates, ọgwụ ọgwụ ọjọọ na ọgwụ na-egbochi ịba ụba Hyhostension hypotension ka njọ.

Ọgwụ Antidiabetic (ọgwụ na insulin)

Ojiji nke thiazides nwere ike imetụta ndidi glucose, n'ihi mgbanwe nke ọgwụ ọgwụ antidiabet nwere ike ịdị mkpa. Ekwesịrị iji Metformin kpachara anya n'ihi ihe egwu nke lactic acidosis nke kpatara ọdịda akụrụngwa nke arụ ọrụ metụtara jikọtara hydrochlorothiazide.

Ọgwụ ndị ọzọ na-alụ ọgụ na-ahụ maka mmụba.

Cholestyramine na colestipol resins

A na-ebelata mmiri hydrochlorothiazide mgbe ekpughere ọnụnọ mgbanwe anion. Otu ọgwụ cholestyramine ma ọ bụ kọlestrọl resinsiles na-ejikọ hydrochlorothiazide, na -ebelata ntinye ya na eriri afọ site na 85% na 43%, karị. Corticosteroids, hormone adrenocorticotropic (ACTH)

Nsonaazụ akpọlata na mkpokọta electrolytes (ọkachasị, hypokalemia). Amịrị pressor (dịka ọmụmaatụ adrenaline)

Mmeghachi omume adịghị ike maka amịrị ndị na - eme ka ọ na - enwe nsogbu enwere ike, n'agbanyeghị, ezughi iji gbochie ojiji ha.

Nkwonkwo akwara na-esighi ike, ndị na-anaghị emebi emebi (dịka ọmụmaatụ tubocurarine) nwere ike ịbawanye ike na akwara.

Diuretics belata mkpụchasị lithium na akụrụ ma bulie ohere nke nsonaazụ ya yana nsị. Nkwado ngalaba-atụ aro.

Ogwu ana akpo gout (probenecid, sulfinpyrazone na allopurinol)

Imezi ọgwụ nke uric acid ga - adị mkpa, n'ihi na iji hydrochlorothiazide nwere ike ibute mmụba nke uric acid na plasma ọbara. May nwere ike ịbawanye dose nke probenicide ma ọ bụ sulfinpyrazone. Ọgwụ Thiazide nwere ike ime ka ohere ịmụba mmadụ na ịba ọcha n'anya nye allopurinol.

Anticholinergics (dịka ọmụmaatụ atropine, biperiden)

N'ihi mmebi nke eriri afọ na ịmịcha nke eriri afọ, bioavailability nke thiazide diuretics na-abawanye.

Ndị nnọchi anya cytotoxic (dịka ọmụmaatụ cyclophosphamide, methotrexate)

Thiazides nwere ike belata mmịpụta nke ọgwụ cytotoxic na mmamịrị ma mee ka ọrụ ha dị na ya belata ọrụ ụmị ọkpụkpụ.

Mgbe ị na-etinye salseslates dị elu, hydrochlorothiazide nwere ike ịkwalite mmetụta ha na-egbu egbu na sistemụ akwara. ,

Achọpụtala ikpe dị iche iche anaemia haemolytic na ojiji jikọtara hydrochlorothiazide na methyldopa.

Iji ihe cyclosporine na-ejikọ ọnụ nwere ike ịbawanye ohere nke hyperuricemia na nsogbu na-akpata gouty.

Hypokalemia ma ọ bụ hypomagnesemia nke ọrịa thiazide na-akpata nwere ike ibute ọgụ nke obi arrhythmia nke digitalis kpatara.

Ọgwụ ndị ihe ha mere gbanwere ngbanwe nke ọkwa potassium n’ime ọbara

A na-atụ aro mkpebi oge nke ọkwa potassium na ECG na-ejikọta ya na ojiji nke ngwakọta nke losartan / hydrochlorothiazide na ọgwụ, mmetụta nke dabere na ntinye uche nke potassium na plasma ọbara (dịka ọmụmaatụ, Digitalis glycosides na ọgwụ antiarrhythmic), yana ọgwụ ndị na-akpata “torsades de pointes” ( ventricular tachycardia), tinyere ụfọdụ ọgwụ antiarrhythmic (hypokalemia bụ ihe na - ebute ọgwụ ike nke achricular tachycardia):

ọgwụ 1a antiarrhythmic ọgwụ (quinidine, hydroquinidine, obedipyramide), klas III antiarrhythmic ọgwụ (amiodarone, sotalol, dofetilide, ibutilide),

ụfọdụ ọgwụ ogwu (thioridazine, chlorpromazine, levomepromazine, trifluoperazin, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol),

ndị ọzọ (bepridil, cisapride, difemanil, erythromycin (maka nchịkwa intravenous), halofantrine, misolastine, pentamidine, terfenadine, vincamine (maka nchịkwa intravenous)).

Thiazide diuretics nwere ike ime ka mkpụkọ nnu ndị dị na plasma ọbara dịkwuo ukwuu site na ibelata ntụpụ ha. Ọ bụrụ na ọ dị mkpa, nhọpụta nke ọgwụ ọgwụ ndị a kwesịrị ileba anya ịba ụba nke calcium na, dabere na nsonaazụ ya, na-arụ ọrụ nhazi.

Mmetụta na nsonaazụ ụlọ nyocha

Site na emetụta metabolism nke calcium, thiazide diuretics nwere ike imegharị nsonaazụ nke ọmụmụ nke ọrụ nke glands parathyroid.

Enwere ihe ize ndụ nke hyponatremia symptomatic. Achọrọ nlere anya nyocha ahụike na ndu onye ọrịa.

N'ihe banyere akpịrị mmiri kpatara diuretics, ihe ọghọm nke ọdịda akụrụngwa na-abawanye nke ukwuu, ọkachasị na oke nke ọgwụ ayodiin nwere. Tupu iji ụdị ahụ, onye ọrịa ahụ kwesịrị ịmịgharịa.

Amphotericin B (maka nchịkwa parenteral), corticosteroids, ACTH ma ọ bụ ọgwụ ndị na-akpali akpali.

Hydrochlorothiazide nwere ike ịbawanye elektrolyte elektrolyte, karịsịa hypokalemia.

Njirimara ngwa

Mmetụta ikike ịnya ụgbọ ala ma ọ bụ usoro ndị ọzọ Mgbe ị na-eme ihe ndị chọrọ nlebara anya karị (ịkwọ ụgbọ ala, na-arụ ọrụ na usoro mgbagwoju anya), ekwesiri icheta na ọgwụgwọ hypotensive mgbe ụfọdụ na-akpata ọgbụgbọ na ụra, karịsịa na mmalite nke ọgwụgwọ ma ọ bụ mgbe ịbawanye ụba.

Nchedo nchekwa

Ndị ọrịa nwere akụkọ ọdịnala kwesịrị ịnọ n'okpuru nlekọta ahụike siri ike (ọzịza nke ihu, egbugbere ọnụ, akpịrị, na / ma ọ bụ ire).

Hypotension na mbelata nke olu intravascular

N'ime ndị ọrịa nwere hypovolemia na / ma ọ bụ hyponatremia (n'ihi usoro ọgwụgwọ diuretic kpụ ọkụ n'ọnụ, nri nri nwere ntakịrị sodium, afọ ọsịsa ma ọ bụ vomiting), hypotension nwere ike ime, ọkachasị mgbe ị theụchara ọgwụ mbụ. Ọnọdụ ndị a chọrọ mgbazi tupu ịmalite ọgwụgwọ.

Electrolyte ahaghioke

A na - ahụkarị ihe elektrọnik elebara anya na ndị ọrịa nwere ọrịa akụrụ, ọkachasị ọnụnọ ọnya shuga. Ya mere, n'oge ọgwụgwọ, ekwesịrị ilebara ndọta nke potassium na plasma ọbara na klọọkụ mmiri creatinine, ọkachasị, na ndị ọrịa nwere nhichapụ mkpụrụ osisi nke 30 - 50 ml / min.

Ọrụ imeju na-arụ ọrụ

Ekwesịrị iji ọgwụ Lorista ND mee ihe na nlezianya na ndị ọrịa nwere akụkọ imeju dị nwayọ ma ọ bụ na-adịghị ala.

Ebe enweghi data banyere ọgwụgwọ ọgwụgwọ nke losartan na ndị ọrịa nwere oke ịba ọcha n'anya, ọgwụ Lorista ND na-emegide ụdị ndị ọrịa. i

Renrụ ọrụ na-arụ ọrụ na ụlọ

N'ihi mkpochapụ nke usoro renin-angiotensin-aldosterone-1g, mgbanwe dị na ọrụ gbasara akụrụ, gụnyere ọdịda akwara, ka emere (ọkachasị, na ndị ọrịa nwere oke ọrụ gbasara akụrụngwa na sistemụ renin-angiotensin-aldosterone: ndị ọrịa nwere nnukwu nkụchi obi ma ọ bụ nke na-adịghị ala ala renal).

Dịka ọgwụ ọjọọ ndị ọzọ na-emetụta sistemụ renin-angiotensin-aldosterone, ndị ọrịa nwere akụrụ akpụ akwara stenosis ma ọ bụ akwara akwara nke otu akụrụ gosipụtara mmụba nke urea na creatinine, mgbanwe ndị a na-agbanwegharị mgbe a kwụsịrị ọgwụgwọ. Jiri nlezianya jiri losartan mee ihe na ndị ọrịa nwere obere akwara ma ọ bụ akwara akwara.

Enweghị data banyere iji ọgwụ ahụ eme ihe na ndị ọrịa na-awa ahụ akwara.

N'ime ndị ọrịa nwere hyperaldosteronism bụ isi, dịka iwu, ọ nweghị mmeghachi omume ọgwụ ndị na-egbochi ọgwụ mgbochi na-egbochi usoro renin-angiotensin. Ya mere, akwadoghi iji ngwakọta nke losartan / hydrochlorothiazide.

Ọrịa obi na ọnya ụbụrụ na ọrịa ụbụrụ

Dị ka ọ dị ọgwụ ọ bụla ọzọ, mbelata ọbara mgbali na ndị ọrịa nwere ọrịa obi na ọrịa ụbụrụ nwere ike ibute infarction myocardial ma ọ bụ ọrịa strok. Obi ada mba

Ndị ọrịa nwere nkụda obi (ma ọ bụ na-enweghị akụrụ gbasara akwara) nwere ohere dị elu nke ịmalite hypotension akwara hyperension na ọdịda akwara (ọ na-ada nnukwu).

Mitral ma ọ bụ aortic valve stenosis, mgbochi ụbụrụ na-egbochi hypertrophic cardiomyopathy

Dị ka ọ dị na ndị vasodilators ndị ọzọ, a ga-elebara anya pụrụ iche mgbe ị na-enye ndị ọrịa ọgwụ na aoicic stenosis, mitral valve stenosis, na mgbochi hypertrophic cardiomyopathy.

E gosiputara na ndị na - egbochi enzyme, losartan, na ndị ọzọ na - emegide antiotensin nwere mmetụta na - adịchaghị mma mgbe ejiri ndị agbụrụ Africa. Ikekwe a kọwara ọnọdụ a site n'eziokwu ahụ bụ na ụdị ndị ọrịa a na-enwekarị mmiri ala. Ime

Ekwesighi iburu Angiotensin II ihe mgbochi (ARA-I) n'oge ime. Ọ bụrụ na ọ ga - ekwe omume, mgbe ahụ ndị ọrịa na - eme atụmatụ ịtụrụ ime ka a ga - enyerịrị ụdị ọgwụgwọ ọgwụ mgbochi ọzọ, ndị gosipụtarala onwe ha n'ihe gbasara nchekwa mgbe ejiri ha n'oge afọ ime. Mgbe etesịrị ime, ARA-a ga-akwụsị ya ozugbo ọzọ usoro ọgwụgwọ ọzọ ka etinyere ma ọ bụrụ na ọ dị mkpa.

Hypotension na mmiri eleghara anya mmiri

Dị ka ọ dị n'ọgwụgwọ ọgwụ ndị ọzọ, ụfọdụ ndị ọrịa nwere ike ịnwe hypotension Symptomatic art art hypotension. Ya mere, emere nyocha nke usoro iji mata ihe omimi akara nke mmiri elektrik (hypovolemia, hyponatremia, hypochloremic alkalosis, hypomagnesemia ma ọ bụ hypokalemia), dịka ọmụmaatụ, mgbe ọ gbasịrị ma ọ bụ ọgbụgbọ. N'ime ndị ọrịa dị otú a, ọ dị mkpa ka a na-enyocha ihe niile elebara elektrik anya. plasma. Na yoga, ndị ọrịa na-arịa ọrịa edema nwere ike ịbụ hyponatremia.

Mmetụta metabolism na sistemụ endocrine

Usoro ọgwụgwọ nke Thiazide nwere ike iduga ịnwe ndidi glucose na-arịa ọrịa. chọrọ ndozi nke ọgwụ antidiabetic, incl. insulin Mgbe ejiri thiazide ọgwụgwọ, ọrịa shuga latent mellitus nwere ike igosipụta. Thiazides nwere ike belata ihie kalsel na mmamịrị ma, yabụ, na-eduga na mmụba dị mkpirikpi obere na ntinye ya na plasma ọbara. Nnukwu hypercalcemia siri ike nwere ike igosi hyperparathyroidism latent. Tupu ị nyochaa ọrụ nke glands parathyroid, thiazide diuretics kwesịrị ịkwụsị.

Ojiji nke thiazide diuretics nwere ike jikọta ya na mmụba nke cholesterol na triglycerides.

N'ime ụfọdụ ndị ọrịa, ọgwụ thiazide nwere ike ịkpalite hyperuricemia na / ma ọ bụ ọgụ nke gout. Ebe ọ bụ na losartan na-ebelata mkpụkọ uric acid, njikọta ya na hydrochlorothiazide na-ebelata ohere nke hyperuricemia metụtara ojiji nke diuretics.

Ọrụ imeju na-arụ ọrụ

N'ime ndị ọrịa nwere ọria imeju ma ọ bụ ọrịa imeju na-aga n'ihu, ekwesịrị iji thiazides jiri nlezianya mee ihe, n'ihi na ha nwere ike ibute cholestasis intrahepatic, na obere mgbanwe mmiri na nguzozi electrolyte nwere ike ịkpasu coma na imeju. Lorista ND nwere contraindicated na ndị ọrịa nwere nnukwu ọrịa ịba ọcha n'anya.

Ndị ọrịa na-ewere thiazides nwere ike ịnwe mmeghachi omume onwe onye, n'agbanyeghị ma ha nwere akụkọ banyere allergies ma ọ bụ ụkwara ume ọkụ. Enwere akụkọ nke iwe ma ọ bụ ịmaliteghachi nke sistemu lupus erythematosus site n'iji ọgwụ thiazide.

Mmetụta akụkụ

N'ozuzu, a nabatara ọgwụgwọ na ngwakọta hydrochlorothiazide + losartan. N'ọtụtụ oge, mmeghachi omume dị nro dị nro, dị obere oge, ọ chọghịkwa ịkwụsị ọgwụgwọ.

N'ime ule ụlọ ọgwụ a na-achịkwa na ọgwụgwọ nke ọbara mgbali elu, dizzness bụ naanị mmeghachi omume ọjọọ metụtara ị takingụ ọgwụ, ugboro ole nke gafere karịa mgbe ị na-ewere placebo karịa ihe karịrị 1%. Dị ka egosiri na ule ụlọ ọgwụ a na-achịkwa, a na-anabata losartan yana hydrochlorothiazide na ndị ọrịa nwere ọbara mgbali elu na ogwe aka ventricular. Mmeghachi omume kachasị emetụta bụ sistem na nkụda mmụọ, adịghị ike / ike ọgwụgwụ. N’oge ndebanye aha na nchikota a, a na-elele nnwale ụlọ ọgwụ na / ma ọ bụ na ndebanye aha onye ọzọ na-arụ ọrụ nke ngwakọta a, a kọkwara mmeghachi omume ndị ọzọ na-esote.

Ọrịa site na ọbara na sistem lymphatic: thrombocytopenia, anaemia, aplastic anaemia, hemolytic anaemia, leukopenia, agranulocytosis.

Ọrịa sistemụ immune: A na - ahụkarị mmeghachi omume anaphylactic, angioedema, gụnyere ọzịza nke ogwooro na olu na - eme ka ihe na - egbochi ntụgharị ikuku na / ma ọ bụ ọsịsọ nke ihu, egbugbere ọnụ, pharynx na / ma ọ bụ ire n'ime ndị ọrịa na - ewere losartan, adịghị ahụkarị (≥0.01% na 5.5 a hụrụ meq / l) na 0.7% nke ndị ọrịa, n'agbanyeghị, n'ọmụmụ ihe ndị a, ọ dịghị mkpa ịkagbu njikọ hydrochlorothiazide + losartan n'ihi nrịba hyperkalemia. Mmụba na ọrụ plasma alanine aminotransferase dị ụkọ ma na-alaghachi na nkịtị ka ọ kwụsịrị ọgwụgwọ.

Dodoụbiga ya ókè
Enweghị data dị mkpa maka ị ofụ ọgwụ oke ókè yana ngwakọta hydrochlorothiazide + losartan. Ọgwụgwọ a bụ Symptomatic ma na-akwado. Ekwesịrị ịkwụsị ọgwụ Lorista ® ND, a ga-enyocha onye ọrịa ahụ. Ọ bụrụ na ewere ọgwụ a n’oge na-adịbeghị anya, a na-atụ aro ka ọ kpalite ọgbụgbọ, yana iwepụ mmiri akpịrị, mmiri-electrolyte, mmiri ịba ọcha n’anya na mbelata ọbara mgbali site n’ụzọ ọkọlọtọ.

Losartan
Ibelata ozi karịrị akarị. Ngosipụta nke oke ị overụ oke bụ mbelata akara ọbara mgbali na tachycardia, bradycardia nwere ike ime n'ihi mkpali parasympathetic (vagal). N'ihe banyere mmepe nke hypotension hyptension, a na-egosipụta ọgwụgwọ mmezi.
Ọgwụgwọ: usoro ọgwụgwọ symptomatic.
Losartan na metabolite na-arụ ọrụ ya adịghị ama jijiji site na hemodialysis.

Hydrochlorothiazide
Ihe nrịba ama a na-ahụkarị n ’oke mmiri bụ n’ihi ụkọ elektrolyte (hypokalemia, hypochloraemia, hyponatremia) na akpịrị ịkpọ nkụ n’ihi oke akwara. Site na nhazi oge nke cardiac glycosides, hypokalemia nwere ike ime ka usoro arrhythmias ka njọ.
E guzobere ya otu ihe enwere ike iwepu hydrochlorothiazide n'ahụ site na hemodialysis.

Aha na adres njide (njide) nke asambodo ndenye aha

Emeputa:
1. JSC “Krka, dd, Novo mesto”, Šmarješka cesta 6, 8501 Novo mesto, Slovenia
2. LLC “KRKA-RUS”,
143500, Russia, Russia Mpaghara, Istra, ul. Moskovskaya, 50
na nkwado na JSC “KRKA, dd, Novo mest”, Šmarješka cesta 6, 8501 Novo mesto, Slovenia

Mgbe nkwakọ na / ma ọ bụ nkwakọ ngwaahịa n'ụlọ ọrụ Russia, egosiri:
KRKA-RUS LLC, 143500, Russia, Moscow Region, Istra, ul. Moskovskaya, 50

Aha na adresị nke ọgbakọ na-anabata mkpesa ndị ahịa
LLC KRKA-RUS, 125212, Moscow, Golovinskoye Shosse, Nrọ 5, Buildinglọ 1

Weputara udi ya na ihe mebere ya

Ọ dị n'ụdị mbadamba. Bu n'obi iji ọnụ. Mbadamba ahụ nwere ihe ndị a na-arụsi ọrụ ike:

isi ihe na - arụ ọrụ bụ losartan, 100 mg,
hydrochlorothiazide - 25 mg.

Ọgwụ dị na onunu ogwu nke 12, 25, 50 na 100 mg.

Lorista ND dị n'ụdị mbadamba.

Mlọ ọgwụ

Maximum mejupụtakarị ihe ndị dị gara gara na-arụ ọrụ na-apụta otu awa mgbe ewerela mbadamba nkume ndị ahụ. Mmetụta ọgwụgwọ ahụ na-adịgide ruo awa 3-4. Ihe dị ka pasent 14 nke losartan, nke a na-ewere n'ọnụ, bụ metabolized to metabolite na-arụ ọrụ ya. Ndụ ọkara nke losartan bụ awa 2. Hydrochlorothiazide adịghị metabolized ma ọ na-apịpụta ngwa ngwa site na akụrụ.

Gịnị na-enyere aka?

Edere ọgwụ ahụ n'ọnọdụ ndị dị otú a:

Ọbara ọbara.
Dị ka ọgwụ na-akwado iji belata onwu na ndị mmadụ na-arịa ọbara mgbali elu ventricular ma ọ bụ ọbara mgbali elu.
Mgbochi ihe ize ndụ nke ọrịa strok, nkụchi obi, mmebi myocardial na pathologies nke usoro obi.
Akpachapụ anya mmadụ na anabataghị onye ọ bụla na ndị na-egbochi isoenzyme.
Ọbara mgbali akwara, ibulite megide mmalite nke ọrịa shuga mellitus, ọdịda akụrụ.
Ọkpụkpụ akwara siri ike.
Myocardial infarction n'ụdị nnukwu.
Obi adaa obi site na usoro usoro ihe ojoo.

A na-atụ aro ọgwụ ahụ ka ọ dị ka ọgwụ nke agbadoro iji kwadebe ndị ọrịa nwere nsogbu gbasara ezumike nka maka ịba ọcha n'anya.

Enwere ike ịkwado ọgwụ ahụ dịka akụrụngwa nke usoro ọgwụgwọ siri ike iji kwadebe ndị ọrịa nwere ọrụ ezumike ezumike ya maka ọgwụgwọ ọrịa hemodialysis.

Jiri nlezianya

Site n'ichekwu ịba ụba, a na-enye Lorista ndị ọrịa ọria ndị a chọpụtara ọrịa:

ọrịa shuga mellitus
ụkwara ume ọkụ,
ọrịa na-adịghị ala ala nke ọbara,
mmebi nke mmiri-electrolyte itule ahu,
stenosis nke akụrụngwa
imebi mgbasa ọbara na microcirculation,
ọrịa akwara ọbara
kadioyopathy
nnukwu arrhythmia n'ihu ọnya obi.

N'okwu ndị a niile, a na-atụ aro ọgwụ ahụ na ntakịrị opekempe, a na-enyochakwa usoro ọgwụgwọ ahụ ike.

Etu esi ewere Lorista ND?

Ezubere maka iji ime ụlọ. Mbadamba ụta ga-eripịa mgbe nri gachara, wee jiri mmiri dị ọcha sachaa ya. A na-ahọrọ usoro ọgwụgwọ kachasị mma dịka otu atụmatụ si eleba anya na afọ onye ọrịa yana ọrịa chọpụtara ya.

Maximumbọchị Lorista na-agbadata kwa ụbọchị ekwesịghị ịkarị 50 mg.

N'ọnọdụ ụfọdụ, dọkịta nwere ike ịbawanye usoro ị toụ ọgwụ na 100 mg nke ọgwụ kwa ụbọchị. Ogologo oge ọgwụgwọ bụ izu atọ ruo ọnwa 1.5.

Mbadamba ụta ga-eripịa mgbe nri gachara, wee jiri mmiri dị ọcha sachaa ya.

Ọgwụgwọ bidoro na obere onunu ogwu - si 12-13 mg Lorista kwa ụbọchị. Mgbe otu izu gasịrị, a na-abawanye ọgwụ a na-eme kwa ụbọchị ruo 25 mg. Mgbe ahụ, a na-ewere mbadamba ahụ na usoro nke 50 mg.

Site na ọbara mgbali elu, ọgwụ ụbọchị nwere ike ịbụ 25 ruo 100 mg. Mgbe ị na-edepụta usoro onunu ogwu buru ibu, o kwesiri ike eke ubochi n’aho abuo. N'ime usoro ọgwụgwọ nke ị anụ ọgwụ ọgwụ diuretic na-abawanye, a na-enye Lorista ọnụego 25 mg.

Obere mbelata ka achọrọ ndị ọrịa nwere ọrụ ịba ọria ume, ọdịda akụrụ.

Na-arịa ọrịa shuga

Ọgwụgwọ bidoro na onunu ogwu nke 50 mg. Mbadamba ụrọ na-ewere oge 1 kwa ụbọchị. N'ọdịnihu, usoro ịba ụba abawanyele 80-100 mg, ana ewere ya otu ugboro kwa ụbọchị.

N'ime ọrịa shuga mellitus, ọgwụgwọ malitere site na usoro onunu ogwu nke 50 mg.

Ọkpụkpụ afọ

flatulence
ọgbụgbọ na ụkwara nke ọgbụgbọ
nsogbu ọnya
eriri afọ
mgbu n'ime afọ.

Ornabata Lorista nwere ike ịkpalite ọgba aghara.

Sistemụ akwara Central

Mwepu nke isi ọwụwa, ịda mba, ọgba aghara ụra, nkụda mmụọ, ọrịa ike ọgwụgwụ na-adịghị ala ala, nkụda mmụọ, belata ikike icheta ozi ọhụrụ na itinye uche, nhazi nke mmegharị.

Mwepu isi ọwụwa nwere ike ịda mgbe ị na-ewere Lorista.

Ọgwụ nwere ike kpalite mmepe nke mmeghachi omume nfụkasị ahụ, gosipụtara n'ụdị:

rhinitis
ụkwara
Akpụkpọ ahụ na-adị ka hives,
akpụkpọ anụ?

Ntụziaka pụrụ iche

N'ihi mmetụta bara ụba na sistemụ akwara na mbelata ọbara mgbali elu n'oge ọgwụgwọ, Lorista ka mma izere ịchịkwa igwe na ụgbọ ala.

N'oge ọgwụgwọ, Lorista ka mma ịhapụ ịkwọ ụgbọala na ụgbọ ala.

N'oge usoro ọgwụgwọ, a na-atụ aro ka ị nyochaa ọkwa nke kalsel ọbara iji zere mmepe nke hypercalcemia.

Oge nwa Lorista ND

N'ihi mmetụta a na-amụ nke ọma nke Lorista nwere n'ahụ ụmụaka ahụ, ejighị ọgwụ ahụ na-agwọ ụmụaka na-erubeghị afọ ole ha.

A naghị eji ọgwụ ahụ agwọ ọrịa ụmụaka na-erubeghị afọ ole ha dị.

Jiri n'oge ime na lactation

N'ihi mmetụta ya na-egbu egbu, ọgwụ ahụ nwere ike imetụta usoro nke akwara gbasara akwara yana ngwa nwa nke nwa ebu n'afọ n’oge mmepe nwa ebu n’afọ, nke juputara na ọnwụ. Ihe ọghọm diri nwa ebu n’afọ dị ezigbo ukwuu n’ime ọnwa abụọ mbụ mbụ nke ịtụrụ ime. Maka nke a, Lorista ejighi nwanyi di ime.

Ejila Lorista n’oge ara. Ọ bụrụ na ọ dị mkpa, a na-ebugharị iji ọgwụ a na-egbochi ihe ọkụkụ nwa oge na inye mmadụ nri.

Jiri maka ọrụ ezighi ezi na-arụ ọrụ

N'ọnọdụ nrụrụ ọrụ akwara ọrụ dị nro dị nro ruo n'ogo, a na-atụzi ọgwụ ahụ na usoro ọkọlọtọ. N'ọnọdụ ndị siri ike, dọkịta na-ekpebi mkpebi maka ezigbo ogo yana ohere nke itinye Lorista.

N'ọnọdụ nrụrụ ọrụ akwara ọrụ dị nro dị nro ruo n'ogo, a na-atụzi ọgwụ ahụ na usoro ọkọlọtọ.

Mmekọrịta na ọgwụ ndị ọzọ

Site n'otu oge iji Lorista na ọgwụ ndị ọzọ na - egbochi ọgwụ mgbochi, a na - enweta mbelata ngwa ngwa ma dị irè nke ndị gosipụtara ọbara mgbali elu.

Nchikota ya na ogwugwo na ogwu mgbochi nwere ike itughari mmepe nke ida.

Barbiturates na kaadi glycosides na-ejikọ nke ọma na Lorista, n'adịghị ka Rifampicin, nke na-ebelata ịdị irè nke ọgwụ a. Asparkam dakọtara na Lorista, mana n'iji ọgwụ ndị a, n'otu oge, a chọrọ njikwa elu nke ọkwa calcium.

Mmanya ndakọrịta

N'oge usoro ọgwụgwọ, Lorista machibidoro ị useụ ihe ọholicụholicụ na-aba n'anya ókè. Mmanya Ethyl na-eme ka onye ọrịa nwee ike ibute ọrịa ndị dị ize ndụ dịka nkụchi obi na ọrịa strok.

N'oge usoro ọgwụgwọ, Lorista machibidoro ị useụ ihe ọholicụholicụ na-aba n'anya ókè.

Onye dochie ọgwụ a bụ Lorista N. ọgwụ ndị na-esote nwere ike ịbụ ihe ọzọ na losartan:

Ọnọdụ nchekwa maka ọgwụ

A na-atụ aro ọgwụ a ka echekwa ya n'ebe gbara ọchịchịrị, dị jụụ site na ụmụaka agaghị eru. Ọnọdụ nchekwa kachasị mma dị ka + 30 Celsius С.

A na-atụ aro ọgwụ a ka echekwa ya n'ebe gbara ọchịchịrị, dị jụụ site na ụmụaka agaghị eru.

Ndi Okacha Cardio

Valeria Nikitina, dibia bekee, Moscow

Ojiji nke Lorista ND na-enye gị ohere ịkwụsị mmepe nke nsogbu ndị dị ize ndụ nke ọrịa pathologies nke usoro obi dịka ọrịa strok na infarction ọrịa myocardial. N'ọgwụ ndị ahọpụtara n'ụzọ ziri ezi, ndị ọrịa na-anabata ọgwụ ahụ nke ọma na-enweghị mmepe nke nsonaazụ.

Valentin Kurtsev, prọfesọ, kadiologist, Kazan

Ojiji nke Lorista zuru ebe nile. Omume ọgwụ na nsonaazụ nke ule nyocha egosila na ọgwụ na-ebelata oke onwu n’etiti ndị ọrịa nwere ọrịa obi na ọbara mgbali elu.

Ọgwụ ahụ meriela ọtụtụ ọnụọgụ nyocha dị mma sitere na ndị ọrịa na ndị dọkịta.

Nina Sabashuk, 35 afọ, Moscow

Anọwo m na-arịa ọbara mgbali elu ruo afọ 10. Mgbe ọrịa ọbara ọbara gachara m, agara m ọtụtụ ọgwụ, mana naanị iji Lorista ND na-enye m ohere ịkwụsị ọnọdụ m ngwa ngwa wee laghachi ụdị ndụ m n'oge ụbọchị ole na ole.

Nikolay Panasov, 56 afọ, Eagle

Ana m anabata Lorista ND ọtụtụ afọ. Ọgwụ ngwa ngwa na-eweghachi nrụgide na nkịtị, na-enye ezigbo nsonaazụ. Ọnụ ego ọgwụ a dịkwa ọnụ ala, nke dịkwa mkpa.

Alexander Panchikov, onye gbara afọ 47, Yekaterinburg

Enwere m nkụda mmụọ na usoro na-adịghị ala ala. Site na iwe ahụ ọkụ karịa, dọkịta nyere iwu ịnara mbadamba Lorista ND. Enwere m afọ ojuju na nsonaazụ ahụ. N’agbanyeghi otutu nsogbu ndi ozo di, ogwu a toro nke oma.