Ọgwụ sitere na otu ahụ akpụ - onye na - asọ mpi nke statin molecule, na - esonyere akụkụ nke ndị na - anabata ya coenzyme A ozugbo na ebe mgbakwunye nke enzyme a, akụkụ ya ọzọ na-akwụsị usoro mgbanwe hydroxymethylglutarate n'ime mevalonate, nke bu ihe di n’etiti ihe banyere otu molekla di cholesterol.

Ọrụ nkwụsị CoA reductase na-ebelata ọdịnaya intracellular cholesterol na mmụba mmụba n'ọrụ LDL onye nnabata, nke na-eduga n'ịba ụba nke catabolism cholesterol (Xc) LDL. Ọ nwere nsonaazụ hypoliplera akpọrọ. Ọgwụ anaghị emetụta ọrụ ịba ọcha n'anya / lipoprotein lipase na catabolism nke ọdụdụ asịd.

Akorta nwere mmetụta dị mma na endothelium nke mgbidi vaskụla (ihe ịrịba ama nke mbido mbụ atherosclerosis), normalizes rheological Njirimara nke ọbara, nwere antiproliferative na antioxidant utịp. Mmetụta kachasị gosipụtara na ụbọchị 30 mgbe mmalite nke ọgwụ ma na-anọgide na nke ahụ n'otu ọkwa ahụ.

Mlọ ọgwụ

A na-etinye ọgwụ ahụ nke ọma na ngọngọ nri. Iri nri na - ebelata oke oriri, bioavailability - ihe dịka 20%. A na - enweta TCmax mgbe - awa 3-5, meriri ihe mgbochi placental. Nnukwu nnwekọ na protein protein (90%). Ọ na - agbakọ na imeju, ebe a na - emegharị ya anya N-dimethyl,metabolites lactone. A na-ewepụta ya n'ahụ site na anụ ahụ ọkachasị n'ụdị na-agbanweghi.

Ihe ngosi maka ojiji

• Dịka mgbakwunye nri hypertriglyceridemia na ọgwụ ịba mba,
• N'ihe banyere ijikọ ọnụ hypercholesterolemia ma ọ bụ isi hypercholesterolemia, n'ihe banyere adịghị ike, njikota nri na usoro ọgwụgwọ ndị ọzọ na-abụghị ọgwụ ịgwọ ọrịa (mmega ahụ, ịta ahụ),
• Iji mee ka usoro mmepe dị ala atherosclerosis mgbe ị na-edepụta ọgwụ anticholesterol,
• Maka mgbochi nke ọrịa obi na ọnụnọ nke ihe ọghọm maka mmepe Ọrịa ọrịa obi Ischemic.

Ihe ngbanwe

Ọrụ akụrụ / arụ ọrụ akụrụngwa, ezi uche dị na akorta, myopathylactation nke afọ imennabata cyclosporine, ụkọ lactase, afọ n’agbata afọ 18.

Jiri nlezianya jiri ndị ọrịa nwere hypothyroidismn'ihe ize ndụ nke mmepe myopathies, na nká, na hypotension akwaraenweghị ike ịchịkwa Akwụkwụ na-adọonye na-a alcoholụbiga mmanya ókè njikọta na fibratesya na nnukwu mmerụ ahụ.

Ntuziaka Akorta maka iji (Usoro na usoro onunu ogwu)

Ekwesịrị ị drugụ ọgwụ a megide nzụlite nri na-egbu ike na onye ọrịa ga-eso ya n'oge usoro ọgwụgwọ. A na-ahọrọ ọgwụ Akorta dabere na ntinye uche nke lipids ma dabere na ebumnuche ọgwụgwọ.

A na-atụ aro ka ị tabletsụ mbadamba ọgwụ Acorta ka ewere ya na usoro ọgwụgwọ nke 10 mg 1 oge kwa ụbọchị yana ohere nke mmụba ya mgbe izu anọ gachara ma ọ bụrụ na ọ dị mkpa ruo 20 mg. Mgbe ị na-ewere mbadamba Acorta, ntuziaka maka ojiji na-egosi mkpa ọ dị maka nyochaa metabolism lipid na mkpa maka ndozi dose.

Mmekorita

Njikọ ọgwụ a gemfibrozil na-abawanye ịta rosuvastatin n’ime ọbara ugboro abụọ. Isoro Concoitant mee ihe maka mgbochi ogwu a na-aria ogwu na abawanye AUC norgestrel na ethinyl estradiolekwesịrị ịtụle ya mgbe ị na-eme ọgwụgwọ ọgwụ mgbochi.

Iji ọgwụ a mee ihe erythromycin na-abawanye site na 20% AUC rosuvastatin. Ido fibrates na nicotinic acid na usoro ọgwụgwọ hypolipidem na-abawanye ihe ize ndụ nke myopathies. N'ikuku rosuvastatin na antacidsnke gunyere aluminom na magnesium hydroxidena-ebelata ịta rosuvastatin n'ọbara site na nkezi nke 50%. Ya mere, a na-atụ aro ka ị antụọ ọgwụ antacids ọbụlagodi awa 2 ka ị werechara mbadamba ihe.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta Aorta n'ụdị mbadamba nkume ndị nwere mkpuchi fim: site na pink ruo na pink dị ọcha, okirikiri, biconvex, na ezumike - site na ude ruo na-acha ọcha (pcs 10. Na blisters, na ngwungwu kaadiboodu nke ngwugwu 1-3).

Ngwakọta 1 mbadamba:

• Ngwakọta ọrụ: rosuvastatin - 10 ma ọ bụ 20 mg (calcium rosuvastatin - 10.4 ma ọ bụ 20.8 mg),
• Ihe ntinye aka (10/20 mg, n'otu aka ahụ): lactose monohydrate (shuga mmiri ara ehi) - 89.5 / 179 mg, microcrystalline cellulose - 29.82 / 59.64 mg, calcium hydrogen phosphate (E341) - 10.9 / 21.8 mg , crospovidone - 7.5 / 15 mg, magnesium stearate - 1.88 / 3.76 mg,
• Shell (10/20 mg, n'otu n'otu): Opadry II 30K240001 pink (lactose monohydrate (shuga mmiri ara ehi)) - 2.4 / 4.8 mg, hydroxypropyl methylcellulose (hypromellose) - 1.68 / 3.36 mg, titanium dioxide - 1.413 / 2.826 mg, triacetin (glyceryl triacetate) - 0.48 / 0.96 mg, sọks na-acha ọbara ọbara - 0.027 / 0.054 mg) - 6/12 mg.

Usoro onunu ogwu na nhazi

A na-ewere mbadamba Acorta ọnụ, n'agbanyeghị nri ahụ, ejiri mmiri sachaa ya. Oge nke ụbọchị ị theụ ọgwụ adịghị emetụta arụmọrụ ya. Mbadamba nkume igwe ihe na Ire.

Tupu nhọpụta Akorta, onye ọrịa kwesịrị ịmalite ịgbaso usoro oriri na-egbu egbu, nke a ga-agbaso dum usoro ọgwụgwọ.

Dọkịta ahụ họọrọ ọgwụ rosuvastatin n’otu n’otu. Ọ bụ ebumnuche usoro ọgwụgwọ na nzaghachi ọgwụgwọ mejupụtara ya, ọ ga-ekwenye na ndụmọdụ ndị a na-anabata ugbu a maka mkpokọta mkpụrụ ndụ.

Ọ gwụla ma dọkịta gosipụtara, a na-ewere Aorta na ọgwụ mbụ nke 10 mg 1 oge kwa ụbọchị. Mgbe ị na-ekpebi ọnụọgụ ọgwụ, ekwesịrị ịcheta ụkpụrụ nke nsonaazụ cholesterol, yana ohere nke ịmalite inwe ọrịa obi na mmeghachi omume ojoo.

Mgbe ọnwa gachara, ọ bụrụ na ọ dị mkpa, mmụba okpukpu abụọ nke ọgwụ ga-ekwe omume.

A na-egosiwanye mmụba kwa ụbọchị (ihe ruru 40 mg) maka ndị ọrịa nwere nnukwu hypercholesterolemia yana nnukwu ihe mgbawa obi (ọkachasị ndị ọrịa nwere famileal hypercholesterolemia), n'ime ndị arụpụtaghị nsonaazụ ọgwụgwọ ahụ mgbe ha na-a lowerụ obere ọgwụ. Ndị ọrịa dị otú a kwesịrị ịnọ n'okpuru nlekọta ahụike, ha kwesịrị ileba anya n'ihe ngosipụta ọrụ gbasara akụrụngwa.

A naghị atụ aro ka ndị ọrịa na-agabeghị dọkịta tupu ha depụta Akorta na ọgwụ 40 mg.

Mgbe izu 2-4 gachara site na mbido ọgwụgwọ, yana iji usoro onyonyo na-aba ụba, ọ dị mkpa iji nyochaa metabolism lipid. Dabere na nsonaazụ ya, enwere ike igosipụta nhọrọ nke dose.

Achọghị usoro maka usoro onunu ogwu maka ndị ọrịa agadi.

Mmụba nke usoro ịta ahụhụ nke rosuvastatin n'etiti China na Japanese, nke ekwesịrị ịtụle mgbe a na-edepụta ọgwụgwọ.

Okpu oke akwara bụ ihe dị mma na ntinye aka nke Akorta na usoro ọ bụla, na-agafeghị oke - n 'ọgwụ kwa ụbọchị nke 40 mg.

Maka ndị ọrịa na-eburu genotypes c.521CC na c.421AA, usoro ọgwụ kwa ụbọchị nke Akorta ekwesịghị ịdị elu karịa 20 mg.

N'ime ndị ọrịa nwere ọrịa imeju (ihe karịrị 9 isi na -kpụrụ Ahụike Childmụaka), enweghị ahụmịhe banyere iji ọgwụ ahụ. Ihe mgbochi na usoro ọgwụgwọ bụ ọrịa imeju na usoro ọrụ.

A naghị akwado ogo kachasị elu kwa ụbọchị nke 40 mg ma ọ bụrụ na enwere ihe ndị nwere ike igosipụta atụmanya nke onye ọrịa na mmepe myopathy.

Ihe ọghọm nke myopathy (gụnyere rhabdomyolysis) na-abawanye na mmụba na mkpokọta plasma nke rosuvastatin, gụnyere n'ihi ngụkọta nke acorta na ọgwụ dịka cyclosporine, ụfọdụ ndị na - egbochi nje HIV (gụnyere jikọtara ritonavir na atazanavir, tipranavir na / ma ọ bụ lopinavir). Ọ bụrụ na ọ ga - ekwe omume, ekwesịrị ịde ya ọgwụgwọ ọzọ Ọ bụrụ na ịchọrọ iji Acorta na ọgwụ ndị a n'otu oge, ịkwesịrị iji kọntaktị na-elele anya na iji ihe egwu nwere ike ijikọ uru ịchọrọ.

Mbadamba Acorta 10 na mg mg 20: ntuziaka maka ojiji

Acorta bụ ọgwụ nke otu ọgwụ ọgwụ akpọrọ statins. Ọtụtụ mgbe, ndị dọkịta na-edenye ya ndị mmadụ na-arịa ọrịa atherosclerosis na ọrịa metabolism ọ bụla ọzọ na ahụ. Ọgwụ a dị n'ụdị nke obere mbadamba ihe mkpuchi. Agba nke mbadamba nkume nwere ike ịbụ n’okpuru nke pink. Ha dị okirikiri n ’udi, nwee akụkụ abụọ, ma ọ bụrụ na agbawaa n’ime, ha na-acha ọcha ma ọ bụ na-agba aja aja.

Isi ihe na-arụ ọrụ nke Akorta bụ rosuvastatin. Ọzọkwa, na mgbakwunye na rosuvastatin, ihe mejupụtara ọgwụ ahụ gụnyere ihe inyeaka dịka lactose, cellulose, calcium, magnesium, crospovidone. Iko mkpuchi nke mbadamba ihe n’onwe ya mejupụtara lactose, hypromellose, titanium dioxide, triacetin na unye n’ụdị kọlọ. All mbadamba nkume ndị a dị na ngwugwu ọkọlọtọ iri iberibe.

Usoro nke ime ihe

Akorta, ma ọ bụ nke ọzọ, isi ya na-arụ ọrụ, rosuvastatin, bụ ihe a na-ahọpụtara na-egbochi enzyme pụrụ iche - hydroxymethylglutaryl-coenzyme Mbelata, nke n'ụdị dị mkpụmkpụ ga-ada ụda dị ka HMG-CoA. HMG-CoA bụ enzyme dị ezigbo mkpa nke na-ahụ maka ntụgharị nke hydroxy-3-methylglutaryl-coenzyme A gaa na ihe akpọrọ mevalonate, ma ọ bụ mevalonic acid.

Mevalonate bụ ihe dị mkpa nke cholesterol, oke buru oke ibu nke bụ ihe kacha akpata ọrịa atherosclerosis. Ngwakọta nke cholesterol na ndakpọ nke lipoproteins dị ala (LDL) na-apụta na imeju. Site na ebe a, enwere ike ikwu ya n'ụzọ ziri ezi na imeju bụ ebumnuche ebumnuche nke ọgwụ a.

Ọgwụ a na - enyere aka ịbawanye ọnụ ọgụgụ ndị nnabata maka mkpụrụ ndụ ume dị ntakịrị n'ihi mkpụrụ ndụ akwara, n'ihi nke nnabata ngwaahịa ha rere ure na-abawanye, na lipoproteins n'efu anaghị abanye n'ọbara. Na mgbakwunye, na imeju, a na-ejikọkwa otu ọzọ nke lipoproteins - njupụta dị ntakịrị (VLDL). Ọ bụ Akorta na-egbochi njikọ ha ma na-ebute mbelata ọkwa ha na ọbara mmadụ.

Rosuvastatin na-enyere aka belata oke cholesterol dị ala na nke dị ala, ma n'otu oge ahụ na - eme ka cholesterol dị mma "dị elu - site na HDL. Ole cholesterol zuru oke, apolipoproteins B (mana, n'aka nke ya, na-abawanye mkpokọta nke apolipoproteins A), a na-ebelata triglycerides nke ukwuu, ọkwa nke "atherogenic" cholesterol kpamkpam.

Usoro a na - akọwa oke ọrụ nke ọgwụ - ịbelata egbugbere ọnụ (n'ụzọ nkịtị - belata oke abụba). Mmetụta a na-adabere kpọmkwem na ọgwụ nke dọkịta na-ahụ maka ịga. Iji mezuo ọgwụgwọ, ya bụ, mmetụta na-akwadokarị, ọ dị mkpa ị takeụ ọgwụ ahụ maka otu izu. Iji nweta ihe kachasị, “ujo” nsonaazụ, ọ dịkarịa ala izu anọ ị na-anara ma na-echekwa usoro na usoro ahụ.

Ngwarta na-eme nke ọma na nhọpụta nke ọgwụ site na ọgwụ ndị na - egbu egbu nke ọgwụ ana - akpọ fibrates, yana acid nicotinic, nke na - enyere aka iwelie ogo nke lipoproteins dị elu.

Usoro onunu ogwu:

Mbadamba ụrọ nke ọ bụla nwere:
ike ọrụ: calcium rosuvastatin - 10.4 mg ma ọ bụ 20.8 mg (na usoro nke ihe na-egbu egbu, nke ya na ọdịnaya nke rosuvastatin - 10.0 mg ma ọ bụ 20.0 mg).
ndị mgbe ochie:
Mbadamba ụrọ:
maka onunu ogwu nke 10 mg - lactose monohydrate (shuga mmiri ara) 89.50 mg, microcrystalline cellulose 29,82 mg, calcium hydrogen phosphate (E 341) 10.90 mg, crospovidone 7.50 mg, magnesium stearate 1.88 mg,
maka onunu ogwu nke 20 mg - lactose monohydrate (shuga mmiri ara ehi) 179.00 mg, microcrystalline cellulose 59.64 mg, calcium hydrogen phosphate (E 341) 21.80 mg, crospovidone 15.00 mg, magnesium stearate 3.76 mg.

Shei:
maka onunu ogwu nke 10 mg - OPADRAY II 30K240001 Pink (OPADRAY II 30K240001 Pink) Lactose monohydrate (mmiri ara ehi) 2.40 mg, hypromellose (hydroxypropyl methylcellulose) 1.68 mg, titanium dioxide 1.413 mg, triacetin (glyceryl triacetate) 0.4 0,527 mg 6.00 mg,
maka usoro onunu ogwu nke 20 mg - OPADRAY II 30K240001 Pink (OPADRAY II 30K240001 Pink) Lactose monohydrate (shuga mmiri ara) 4.80 mg, hypromellose (hydroxypropyl methylcellulose) 3.36 mg, titanium dioxide 2.826 mg, triacetin (glyceryl triacetate) 0.9 oxide uhie oxide 0.054 mg 12.00 mg.

E tinyere mbadamba nkume ndị ahụ site n’ọkụ dị na pink ruo na pink, gburugburu, biconvex. N'oge ezumike site na agba ọcha na agba agba.

Ntuziaka maka iji ọgwụ ahụ

Edere Aorta maka nsogbu dị iche iche nke metabolism lipid.

Ihe ngosi pụtara bụ ọnụnọ nke atherosclerosis.

A na-eji ọgwụ ahụ eme ihe maka mgbakwunye nri iji belata cholesterol na obere ntopute lipoproteins dị ala.

Na mgbakwunye na nke a, a na-enye ọgwụ ahụ:

• Dị ka ndị ọzọ prophylactic ọrịa na nke obi usoro na ọrịa na-enweghị clinical ịrịba ama nke ọrịa obi. Ihe ndị a gụnyere infarction myocardial, ọrịa strok, ọbara mgbali elu. N'okwu a, afọ nke ndị ọrịa dị mkpa - maka ụmụ nwoke ọ dị ogo karịa afọ 50, na maka ụmụ nwanyị - karịa 60. Ọ dịkwa mma ịtụle ọkwa dị ala nke lipoprotein cholesterol na ọnụnọ nke ọrịa obi na-emetụta obi na ndị ikwu nso,
• Hypercholesterolemia nke mbụ dị ka Fredricksen ma ọ bụ ụdị agwakọta bụ mmụba nke cholesterol n'enweghị ihe ọ bụla dị na mpụga. Edere ọgwụ ahụ ka ọ bụrụ ngwa ọzọ, ọkachasị ma ọ bụrụ na ọgwụ ndị ọzọ, nri na mmega ahụ ezughi iji nweta nsonaazụ achọrọ,
• Fourthdị hypertriglyceridem nke anọ dị ka Fredricksen si bụrụ nzọụkwụ ọzọ na njikọta na usoro ọgwụgwọ nri.

Ihe mgbochi igbochi iji Akorty dabere na ogwu nke ogwu. Maka ọgwụ kwa ụbọchị nke 10 ruo 20 mg, mmeghachi omume nfụkasị ahụ, ọrịa imeju na-adịghị ala ala, ma ọ bụ ndị na-adịghị ala ala na nnukwu nsogbu bụ contraindications, nke a na-akọwa nyocha ọbara biochemical dị ka mmụba okpukpu atọ na nlele imeju ma e jiri ya tụnyere ndị nkịtị, ọkwa siri ike nke ọdịda akụrụ, ọdịda mmadụ n'otu n'otu na shuga shuga mmiri ara ehi. (lactose), erughi oke ya ma obu mmetu ya n’enwe ike, onodu akuko nke myopathy (ike adighi ike), inwere ogwu nke akporo Cyclospor. na, mkpụrụ ndụ ihe nketa na mmepe nke myopathy, oge nke afọ ime na lactation na ụmụ nwanyị, obere afọ.

Mgbe dosing Akorta 40 mg kwa ụbọchị, ekwesịrị ịgbakwunye contraindications ndị a na contraindications dị elu:

1. Eriri thyroid - hypothyroidism,
2. Ọnụnọ na akụkọ gbasara onwe gị ma ọ bụ ihe ọzọ gbasara ọrịa nke akwara anụ ahụ,
3. Mmepe nke myotoxicity mgbe ị na-a withụ ọgwụ nwere otu ụdị nke edinam,
4. Alcoholụbiga mmanya ókè,
5. Ọnọdụ ọ bụla nwere ike ibute ịba ụba nke rosuvastatin n’ahụ,
6. Ọrịa nke agbụrụ Mongoloid
7. Jikọtara ejiri fibrates mee ihe

Na mgbakwunye, contraindication bụ ọnụnọ n'ahụ ahụ onye ọrịa nke ike obere akwara na-ada ada.

Mpempe akwụkwọ Mwepụta Acorta

Ọgwụ ahụ dị n'ụdị mbadamba. Shapedị mbadamba nkume ndị ahụ dị gburugburu, akụkụ abụọ. ọ bụrụ na mbadamba ya agbajie na ọkara, mgbe ahụ isi ya ga-abụ agba na-acha ọcha.

Ihe mgbo nke ogwu a sitere na pink di ncha rue odo oji na agba na agba nke shei dabere n’usoro nke isi ihe na mbadamba ihe. Ogwu nwere ogwu nke rosuvastatin 10.0, 20.0 na 40.0 milligrams.

Mpempe akwụkwọ Acorta nwere usoro nke 10 mg nke rosuvastatin:

Ngwa inye aka na mbadamba ụrọ nke nwere sistemu rosuvastatin 10.0:

Ngwakọta nke shei nke ọgwụ Akorta nwere usoro nke rosuvastatin 10.0 milligrams:

Mbadamba mbadamba nwere usoro nke 10.0 milligram rosuvastatin na blister nke mbadamba 10:

• Igbe kaadiboodu nwere ntuziaka nke 1 blister (10 PC),
• Ngwunye kaadiboodu 2 blisters (10 pcs) na nkọwapụta,
• Ihe kaadiboodu nwere ntuziaka maka iji blisters 3 (pcs 10),

Mbadamba ụrọ cholesterol nke pink acorta nwere usoro ọgwụ 20.0:

Ngwa inye aka na mbadamba ụrọ nke nwere sistemu rosuvastatin 20.0:

Ngwakọta nke shei nke ọgwụ Akorta nwere usoro nke rosuvastatin 20.0 milligrams:

Mbadamba ụrọ nwere mbadamba ọgwụ rosuvastatin 20.0 na blister nke mbadamba 10:

• Igbe kaadiboodu nwere ntuziaka nke 1 blister (10 pcs.),
• Igbe kaadiboodu 2 blisters (10 pcs.) Na nkọwapụta,
• Igbe kaadiboodu nwere ntuziaka nke 3 blisters (10 pcs.).

Akorta

Ọgwụ Farmacology

Ngwakọta ọrụ na rosuvastatin ọgwụ nwere amamịghe iji gbochie ọrụ nke enzyme HMG-CoA reductase, yana belata mmepụta mevalonic acid, nke bụ ihe ga - enyere aka na njikọta mkpụrụ ndụ cholesterol na mmalite nke mmepụta ha na sel nke imeju (hepatocytes).

Site n'enyemaka nke ọgwụ ahụ, Akorta, a na-ebelata ego cholesterol, nke na-akpali ndị na-anabata LDL, nke, mgbe ọ na-eme ka ọrụ, na-amalite ịchụ nta nke mkpụrụ ndụ ihe dị ala, na-ejide ha ma na-ebugharị ya na mkpụrụ ndụ imeju maka itinyekwu ya na iji acid bile.

N'ihi ọrụ a nke ndị na-anabata ya, a na-eme ka catabolism nke lipid dịkwuo ala, enwere nnukwu mbelata cholesterol dị ala.

Usoro a na - enyere aka sachapụ plasma ọbara na cholesterol n'efu.

Isi ihe dị na ọgwụ ahụ, rosuvastatin na-egbochi hepatocytes ma belata mmepụta ha nke obere lipids molecula dị ala, nke na-ebelata njikọ nke triglycerides.

Ọgwụ a nwere mmetụta ọgwụgwọ na lipoproteins, na -ebelata njikọta ya site na mkpụrụ ndụ imeju, nke na-agbadata ọkwa nke lipoproteins dị ala dị ala ma na-eme ka mkpokọta lipoproteins dị elu nke belata.

Ihe rụpụtara bụ isi ekpughere HMG-CoA reductase site na ọgwụ Akorta nwere usoro ogwu nke rosuvastatin nke 10.0:

• Akwukwo izugbe nke cholesterol na-agbada site na 36.0%,
• Mbelata nke LDL belatara site na 52.0%,
• Ejiri nkebi triglyceride na 10.0%,
• Apolipoproteins B belata na 42.0%,
• Molecules nke lipoproteins dị elu (HDL) na-abawanye site na 14.0%,
• Apolipoprotein A mụbara na 4.0.

Ngosiputa gosiputara HMG-CoA mbelata ogwu Akorta tinyere ogwu rosuvastatin 20 mg:

• Ihe ndekọ cholesterol dum belata 40.0%,
• Mpelata egbugbere ọnụ dị ala (LDL) belatara site na 55.0%,
• Mpekere nke triglyceride ụmụ irighiri ihe na-ebelata 23.0%,
• Apolipoproteins B na-eji 46.0% belata,
• Enwere mmụba nke ụmụ irighiri akwara ike dị elu (HDL) site na 8.0%,
• Mmụba nke apolipoprotein A site na 5.0%.

Mmetụta ọgbụgba dị nro n’arụ ahụ na-ekwekọ n’usoro enyere n'iwu. Mmetụta ọgwụgwọ ọgwụgwọ na-enweta ume n'ime ụbọchị 7 mgbe mmalite nke Acorta.

Mgbe ụbọchị iri na anọ gachara, a ga-enweta ọgwụ ọgwụgwọ ahụ site na 90.0%, nke na-akwado nyocha nke biochemical nke ihe mejupụtara ọbara plasma na profaịlụ nwere ume.

A na-achọpụta 100.0% nke ọgwụgwọ ọgwụgwọ mgbe ewerechara mbadamba Acorta kwa ọnwa. Mgbe ọ rụsịrị nsonaazụ ma belata ndepụta dị mkpa nke cholesterol, ọgwụgwọ na-aga n'ihu maka ọnwa ọzọ.

Egosiputa akụkụ rosuvastatin nọ n'ọrụ ka egosipụtara dị mma n'ịgwọ ụdị ezinụlọ hypercholesterolemia, yana ịba ụba nke triglycerides ma ọ bụ na-enweghị ọkwa dị elu na ahụ ha.

Ọzọkwa, Akorta dị irè na ụdị ọrịa shuga abụọ a.

Ngwongwo ogwu

Mlọ ọgwụ
Rosuvastatin bụ ihe na - egbochi oke nke hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, enzyme nke na - agbanwe 3-hydroxy-3-methylglutaryl-CoA na mevalonate, nke bụ ihe na-ebute cholesterol. Ebumnuche bụ isi nke rosuvastatin bụ imeju, ebe a na-arụ njikọ nke cholesterol (cholesterol) na catabolism nke lipoproteins dị ala (LDL) dị ala. Rosuvastatin na-abawanye ọnụ ọgụgụ nke ndị na-anabata LDL n'elu hepatocytes, na-abawanye ụba na catabolism nke LDL. Ọ na - egbochi njikọ Lipoprotein cholesterol (VLDL) dị ntakịrị nbelata nke mkpụrụ ndụ akwara, si otú ahụ belata ngụkọta nke LDL na VLDL.
Rosuvastatin na -ebelata mkpokọta nke LDL cholesterol, cholesterol ngụkọta na triglycerides (TG), na-eme ka mkpokọta lipoprotein cholesterol dị elu (HDL-C), ma na-ebelata mkpụkọ nke apolipoprotein B (ApoV), nke na-abụghị HDL cholesterol (mkpo zuru oke cholesterol). ), Cholesterol-VLDL, TG-VLDL ma na - eme ka ngbanye apolipoprotein A-I (ApoA-I) dịkwuo elu. Rosuvastatin belata ogo cholesterol-LDL / cholesterol-HDL, cholesterol / cholesterol-HDL, cholesterol-abụghị HDL / cholesterol-HDL na ApoV / ApoA-I.
Mpempe ume dị n’olu na-agbadata nha etu esi edere.
Mmetụta ọgwụgwọ na-etolite n'ime izu 1 mgbe mmalite nke ọgwụgwọ, mgbe izu abụọ rutere 90% nke nsonaazụ kachasị, mmetụta ọgwụgwọ kachasị na-arụkarị mgbe izu anọ gasịrị ma ana-ejikwa ya na nchịkwa ọgwụ ndị ọzọ.
Ọ dị irè na ndị okenye nwere hypercholesterolemia nwere ma ọ bụ na-enweghị hypertriglyceridemia (n'agbanyeghị agbụrụ, okike ma ọ bụ afọ), gụnyere n'ime ndị ọrịa nwere ọrịa mellitus na ụdị ketara eketa nke hypercholesterolemia.
A na-ahụta mgbakwunye mmetụta na fenofibrate (n'ihe metụtara mbelata mkpokọ nke TG) na nicotinic acid na usoro mkpolata egbugbere ọnụ (karịa 1 g / ụbọchị) (n'ihe metụtara mmụba nke mkpokọta nke HDL cholesterol).

Mlọ ọgwụ
Orkpachara anya: ezigbo bioavailability - 20%. Nri na-ebelata oke nke mmiri. Oge ị ga-eji nweta ntinye uche kachasị (TCmax) bụ awa 3 ruo 3-5 mgbe ịbasịchara. Penetrates site na ihe mgbochi placental.
Nkesa: Rosuvastatin na-eburu ya ụzọ site na imeju, nke bụ saịtị nke cholesterol synthesis na metabolism nke LDL-C. Olu nkesa banyere 134 l. Nkwukọrịta na protein protein plasma (tumadi ya na albumin) - 90%.
Metabolism: 10% nke ọgwụ were were metabolized na imeju. Rosuvastatin bụ mkpụrụ nke na-abụghị isi maka metabolism nke enzymes nke usoro cytochrome P450. CYP2C9 bụ isoenzyme bụ isi na-emetụta metabolism nke rosuvastatin, ebe ndị isoenzymes CYP2C19, CYP3A4, CYP2D6 anaghị etinye aka na metabolism ya.
Ihe karịrị 90% nke ọrụ ọgwụ na igbochi mgbasa HMG-CoA reductase bụ nke rosuvastatin na-enye, nke fọdụrụ bụ metabolites. Ihe bụ isi metabolites nke rosuvastatin bụ N-dismethyl na lactone metabolites. N-dismethyl dị ihe dị ka 50% na-arụ ọrụ karịa rosuvastatin, metabolic lactone anaghị arụ ọrụ ọgwụ.
Ojiji: nke dịpụrụ adịpụ n'ụdị na-agbanweghi agbanwe (90%) site na eriri afọ (gụnyere rosuvastatin na-adọrọ adọrọ na nke a na-ejighị n'aka), ndị ọzọ - na akụrụ. Ọkara ndụ (T½) bụ ihe dịka awa 19. Ọkara ndụ anaghị agbanwe agbanwe yana mmụba nke ọgwụ. Geometric pụtara plasma doro dị ihe dị ka 50 l / h (ọnụọgụ nke mgbanwe 21.7%). Dị ka ọ dị na ndị ọzọ HMG-CoA reductase inhibitors, mmelite hepatic nke rosuvastatin na-ebugharị cholesterol na-ebu ngwongwo (na-ebu protein protein nke anions), nke na-arụ ọrụ dị mkpa na mkpochapu hepatic rosuvastatin.
Ihe ngosi usoro nke rosuvastatin na-abawanye na oke na nha. Achọpụtaghị mgbanwe ndị dị na ọgwụ ọgwụ ọgwụ na iji ọgwụ kwa ụbọchị.
Okike nwoke na afọ anaghị enwe mmetụta dị ukwuu n’ụlọ ọgwụ na ọgwụ ọgwụ nke rosuvastatin.
Ọmụmụ ọgwụ Pharmacokinetic gosipụtara ihe dị ka okpukpu abụọ nke mbuputa AUC (mpaghara n'okpuru oge ịta ahụhụ) na Cmax (oke plasma ịta) nke rosuvastatin na ndị ọrịa agbụrụ Asia (Japanese, Chinese, Filipinos, Vietnamese na Koreans) ma e jiri ya tụnyere ndị Europe, India ndị ọrịa gosipụtara mmụba na mbubata AUC na Cmax na 1, 3 ugboro. Nyochaa nke Pharmacokinetic egosighi ọdịiche pụtara ìhè dị na ọgwụ ọgwụ n'etiti ndị Europe na ndị nnọchi anya agbụrụ ojii.
N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ruo na nke dị ala, mkpokọta plasma nke rosuvastatin ma ọ bụ N-dysmethyl adịghị agbanwe nke ukwuu. N'ime ndị ọrịa nwere nnukwu akụrụ oke (mwepu creatinine (CC)) ndị ọrịa nwere imeju
Enweghị ahụmịhe banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere akara dị elu karịa 9 na ọkwa Child-Pugh.
Jiri nlezianya
Maka ọgwụ a kwa ụbọchị nke 10 na 20 mg: ihe ize ndụ nke ịmalite myopathy / rhabdomyolysis - ọdịda akụrụ, hypothyroidism, akụkọ gbasara onwe gị ma ọ bụ ezinụlọ nke ọrịa akwara na ihe nketa na akụrụngwa na-egbu egbu na ọgwụ ndị ọzọ HMG-CoA mbelata ndị na-egbochi ma ọ bụ na-abụbiga mmanya ókè, ị alcoholụbiga mmanya ókè. ọnọdụ nke enwere mmụba na mkpokọta plasma nke rosuvastatin, afọ karịrị afọ 65, akụkọ banyere ọrịa imeju, sepsis, hypotension, oke ịwa ahụ gụnyere. Twa, trauma, oké metabolic, endocrine ma ọ bụ electrolyte ọrịa, agụụ Akwụkwụ na-adọ, agbụrụ (Mongoloid agbụrụ), concomitant ojiji nke fibrates.
Maka ọgwụ kwa ụbọchị nke 40 mg: ọdịda akụrụ nwa na-adịghị ala ala (CC karịa 60 ml / min), afọ karịrị 65, akụkọ banyere ọrịa imeju, sepsis, hypotension, ịwa ahụ buru ibu, trauma, metabolic siri ike, endocrine ma ọ bụ nsogbu aghara. ma ọ bụ ihe ọdịdọ na-achịkwaghị achịkwa.

Ihe ngosi maka nhọpụta Akorta

Edere ọgwụ Rosuvastatin Canon maka ịgwọ ọrịa ndị dị otú ahụ na-abawanye ndekọ cholesterol na plasma ọbara:

• Primary heterozygous na-abụghị eketa ezinụlọ hypercholesterolemia (ụdị 2A dịka Fredrickson si kwuo),
• Hypercholesterolemia nke mbụ abụghị etiology,
• Hydị hyperlipidemia agwakọta (ụdị 2B dị ka Fredrickson), ihe mejupụtara rosuvastatin si arụ ọrụ dị ka njikọta nke nri cholesterol,
• Pathology nke dysbetalipoproteinemia (ụdị nke 3 dị ka Fredrickson),
• Etiology nke hypertriglyceridemia (Fredrickson ụdị 4),
• Site n'ụdị homozygous nke hypercholesterolemia, a na-eji nri ma ọ bụ ọgwụ ọgwụ cholesterol ndị ọzọ. Ma ọ bụ, nri cholesterol adịghị arụ ọrụ.
• Ka ịkwụsị mmebi nke systemic sclerosis, yana yana nri.

Ihe mgbochi mbu nke ọrịa a:

• Myocardial infarction
• Ọkpụkpụ nke ụbụrụ akụkụ ma ọ bụ ọbara ọgbụgba n'ụbụrụ,
• Cardiac organ ischemia,
• Site na revascularization,
• Mgbe afọ 50 gasịrị na ụmụ nwoke na afọ 60 na ụmụ nwanyị,
• Iji belata protein protein C-reactive.
• Ọrịa nicotine na mmanya riri ahụ,
• Site na mmepe nke ọbara mgbali elu.
• Mgbochi nke angina pectoris ejighị n'aka, yana arrhythmias.

Gosiri maka iji ya mgbe ọnya na-aga

Nsonaazụ

A na-ekewapụta nsonaazụ ndị dị n'ahụ mmadụ ugboro ole ọmụmụ ihe ọmụmụ:

• Zuru ma ọ bụ oge niile, nke a karịrị ikpe 1 n'ime ndị ọrịa 10,
• Ọtụtụ mgbe, nke a bụ ikpe 1 maka ndị ọrịa 100,
• Ọ bụghị oge nke a bụ ikpe 1 maka ndị ọrịa 1000,
• Ọ dịkarịa ala, ikpe 1 na ndị ọrịa 10,000,
• O siri ike ma ọ bụ ọnọdụ dịpụrụ adịpụ 1 gbasara ndị ọrịa 10,000 karịa na-a Aụ ọgwụ Acorta:

Tachycardia bụ otu n'ime mmetụta ndị dị n'ị sideụ ọgwụ.

Usoro Acorta Dosage and Scheme

Iwu banyere ị theụ ọgwụ maka nnukwu kọlestrọl Akort:

• Mmalite ọgwụgwọ ọgwụ na ọgwụ Akorta na-amalite site na nri hypocholesterol,
• Ofzọ niile Acorta ga-esi na-eri nri,
• Dọkịta ahụ hotara usoro ịhọrọ ya iche dabere na ngosipụta nke lipogram,
• Ga-a theụ mmiri niile ahụ, ọ bụghị ịta ata, toụọkwa mmiri dị ukwuu,
• Usoro mbu nke Acorta bụ milligram 10.0, otu ugboro n'ụbọchị, ejikọghị ya na usoro iri nri,
• Dịkwuo ọgwụ ma ọ bụ dochie ọgwụ ahụ, ọ bụ naanị dọkịta na-aga ele anya nwere ike ime analog, mana ọ bụghị tupu mgbe ọnwa ọgwụgwọ gasịrị,
• Usoro ọgwụgwọ kachasị maka ụbọchị ọ bụla bụ 40.0 milligrams, ka enyere ya ọgwụ naanị n'ụlọ ọgwụ n'okpuru nlekọta usoro ahụike nke dọkịta,
• Ọ bụ ndị dọkịta nwere ụdị usoro ọgwụgwọ kachasị maka ndị ọrịa nwere ụdị atherosclerosis dị oke njọ,
• Site na iji ogwu gwo ogha ruru 20.0 milligram, nyochaa cholesterol index ugboro 2 n'ọnwa,
• Ọzọkwa, na oke usoro onunu ogwu kwa ubochi, nyochaa mgbe niile iheineine phosphokinase.
• Ọrịa anaghị emezi okenye maka ndị ọrịa.

Di elu ka usoro onunu ogwu eji arụ ọrụ n’ime mbadamba ihe, ka ukwuu mmetụta adịghị mma n’ahụ dị na njikwa ya. Akort onyunyo nke 40.0 milligram na-akpata nsonaazụ kachasị, yabụ ịkwesịrị ịmalite usoro ọgwụgwọ na obere usoro.

Maka ndị ọrịa nwere nnukwu nsogbu ibute ọrịa obi, ma ọ bụ ọrịa banyere ọbara na-ekesa ọbara, dọkịta nwere ike inye ọgwụ ọgwụ ruru 40.0 milligrams, mana naanị ma ọ bụrụ na ọgwụ Akorta ma ọ bụ ọgwụ analogues nwere usoro onodu a n’okuteghị ewetara ọgwụ ọgwụ na iwetulata cholesterol index. .

Enwere ike ime mmụba nke ọgwụ ahụ naanị mgbe nyochachara nyocha sitere na usoro ndapụta.

Dabere na ule nyocha, dọkịta kpebiri banyere mkpa ọ dị ịbawanye usoro onunu ogwu.

Di elu ka usoro onodu ihe eji arụ ọrụ n’ime mbadamba ihe ahụ, ka mmetụta ahụ ọ na-enwe na-esighi ike n'ahụ ahụ

Ojiji ogwu Akort n’oge di ime

Edeghị ọgwụ Akorta ọgwụ maka ụmụ nwanyị n’oge ha na-amụ nwa, yana oge n’inye nwa ara.

Womenmụ nwanyị mụrụ afọ n'oge ọgwụgwọ na ọgwụ nke otu statin kwesịrị ilekọta ichebe ahụ ha site na ịtụrụ ime nwatakịrị.

Ọ bụrụ na nwanyị achọpụta na nwanyị dị ime n’oge ị Akoụ ọgwụ Akorta, mgbe ahụ ị ga-akwụsịtụ ụzọ ọgwụ ahụ wee chọpụta nne na nwa amụrụ.

Ndụmọdụ ndị pụrụ iche maka nhọpụta

Mgbe ị na-edepụta usoro onunu ogwu nke 40,0 mg nye ndị ọrịa, ọ dị mkpa ileba anya mgbe niile na-emetụta mkpụrụedemede niile. Ọ bụrụ na nchọpụta ahụ gosipụtara mmụba okpukpu ise na ndekọ nke creatine phosphokinase, mgbe emesịrị ụbọchị anọ ruo ụbọchị ise, ịkwesịrị ịmegharị ule ahụ ọzọ.

Ọ bụrụ na nyochaghachiri ahụ gosipụtara otu nsonaazụ ahụ na ozi mbụ, mgbe ahụ ọgwụgwọ ahụ na iji usoro onyunyo nke 40.0 nke Acorta ekwesịghị ịmalite.

Ọ dịkwa mkpa ịkagbu ọgwụgwọ na Acorta maka ọrịa pathologies, ọ bụrụ na creatine phosphokinase na-amụba ugboro ise ma ọ bụ karịa.

Mgbe emeghachite ọnọdụ izugbe na mbelata ihe mgbu akwara, enwere ike ịmaliteghachi ọgwụgwọ ahụ, mana site na iji usoro Acorta adịghị elu karịa milligrams 20.0. Ọgwụgwọ immunosuppressant oge ugbu a nwekwara ike ịdị mkpa.

Site na mmụba na usoro onunu ogwu oge ọgwụgwọ ya na Akorta ruo na ọnụọgụ kachasị, na-enyocha mkpụrụ ndụ mgbe niile na-eji biokemelia tinyere profaịlụ akwara, yana transminases cell cell na ọbara.

Ọ bụrụ na onye ọrịa nwere ntụpọ glucose dị elu karịa 6.0 mmol kwa lita, mgbe ahụ ọgwụgwọ Acorta nwere ike iduga mmepe nke ụdị ọrịa shuga nke abụọ.

N'oge ọgwụgwọ, ịchọrọ nyocha shuga n'ọbara.

Ogwu Akorta bu ihe akuru nke umu nke ano nke nwere rosuvastatin na - aru ​​oru ma nwee otutu analogues nke ndi Russia na ndi si mba ozo:

Ugwọ ọgwụ nke Akort na analogues ya

Mmechi

Ojiji nke ọgwụ Russia iji belata ndekọ ọbara cholesterol nwere ike ịkọwa ya naanị site na dọkịta na-aga ya, yana usoro ọgwụgwọ ya guzobere, a gaghị agbanwe ọgwụ ahụ n'adabereghị ya. Ọgwụ ọgwụ na-eri nri mmanu cholesterol.

A na-eme usoro ọgwụgwọ ahụ site na nyocha nke ndị dibia na-aga mgbe niile na ịtụle cholesterol ndekọ mgbe niile.

Sergey, gbara afọ 54: Afọ atọ gara aga, achọpụtara m na atherosclerosis nke ụkwụ. Nri ahụ belatara cholesterol m, dọkịta dekwara m akpụ. Ejiri m Krestor ọnwa isii, mana ị drinkingụ ọgwụ ndị a mgbe niile dị oke ọnụ.

Ọ gwara dọkịta ahụ ka ọ were ihe oyiyi ndị ọzọ dochie ya, ma nye m ọgwụ Akort. Enwere m afọ ojuju maka nsonaazụ, na maka ọnụahịa ọgwụ Russia na-adabara m.

Anaghị m enwe mmetụta ọ bụla n’akụkụ ahụ, naanị na mmalite enwere adịghị ọgbụgba siri ike.

Galina, 59 afọ: mgbe mmalite nke menopause, kọlestrọl mụ na-agbadata nke ukwuu, amalitekwara m ibu oke ibu.

Emechara nri hypocholesterol, enwere m ike ifelata, mana kọlestrọl m agbadaghị nke ukwuu. Dọkịta nyere m ọgwụ Akorta.

Mgbe ọnwa 2 gachara ọgwụgwọ, cholesterol laghachiri na nkịtị, mana enwere m nri.

Jiri n’oge ime na n’oge a na-enye nwa ara

A machibidoro ọgwụ Akorta ọgwụ maka oge a dị ime na n’oge a na-enye nwa ara. Mụ nwanyị nke afọ omumu kwesịrị iji ụzọ ịtụnanya ịtụrụ ime egbochi. Ebe ọ bụ na kọlestrọl na ngwaahịa biosynthesis cholesterol ndị dị mkpa maka mmepe nwa ebu n’afọ, ihe ọghọm nke igbochi HMG-CoA mbelata ga-erite uru nke ị inụ ọgwụ ahụ n’ime ụmụ nwanyị dị ime. N'ihe dị ime n'oge ọgwụgwọ, ekwesịrị ịkwụsị ọgwụ a ozugbo. Enweghị data maka ịbanye na rosuvastatin na mmiri ara, ya mere, n'oge a na-enye nwa ara, ọgwụ ahụ kwesịrị ịkwụsị.

Usoro onunu ogwu na nhazi

Tupu ịmalite ọgwụgwọ iji ọgwụ ahụ, onye ọrịa ahụ kwesịrị ịmalite ịgbaso usoro oriri na-egbu egbu ma nọgide na-agbaso ya n'oge ọgwụgwọ. Ekwesịrị ịhọrọ dose nke ọgwụ ahụ n'otu n'otu dabere na ebumnuche nke usoro ọgwụgwọ na nzaghachi ọgwụgwọ, na-eburu n'uche nkwenye ndị a na-anabatakarị maka ịba uru lipid.
A na-aralụ ọgwụ ọgwụ Akorta n'oge oge ọ bụla n'ụbọchị n'agbanyeghị agbanyeghị nri, na-enweghị ịta ata ma ọ bụ etipịa mbadamba ahụ, na-elo mmiri kpamkpam, jiri mmiri drinkingụọ mmiri.
Usoro ọgwụgwọ akwadoro (ọ gwụla ma akọwapụtara ya) bụ 10 mg otu ugboro kwa ụbọchị maka ndị ọrịa na-ewerebu ndị na-egbochi HMG-CoA reductase inhibitors na mbụ, yana ndị ọrịa bufere ọgwụ a mgbe ọgwụgwọ ya na ndị ọzọ na-egbochi Htr-CoA reductase inhibitors.
Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ mgbe izu anọ gachara ruo 20 mg.
N'ihi mmepe omume enwere ike ị effectsụ nsonaazụ mgbe ị na-a aụ ọgwụ nke 40 mg, ma e jiri ya na obere doses, ịba ụba nke ọgwụ ahụ ruo 40 mg nwere ike ịme naanị naanị na ndị ọrịa nwere nnukwu hypercholesterolemia yana nnukwu ihe gbasara nsogbu obi (ọkachasị ndị ọrịa nwere famileal hypercholesterolemia ), na nke arụpụtaghị nsonaazụ chọrọ nke ọgwụgwọ mgbe ị na-a aụ ọgwụ 20 mg, nke ga-abụkwa n'okpuru nlekọta ahụike.
A na-atụ aro iji nlezianya nyochaa ndị ọrịa na-anara ọgwụ ahụ na ọgwụ 40 mg. A naghị atụ aro ka a sụọ ọgwụ were 40 mg maka ndị ọrịa na-agabeghị dọkịta. Mgbe izu 2-4 zuru ezu nke ọgwụgwọ na / ma ọ bụ na-abawanye na dose nke ọgwụ, nlekota nke lipid metabolism dị mkpa (ọ bụrụ na ọ dị mkpa, a chọrọ idozi dose).
N'ime ndị ọrịa na-a theụ ọgwụ ahụ na ọgwụ 40 mg, a na-atụ aro ka nyochaa ndị na-egosi ọrụ akụrụ.
Mgbe etinyere ya na gemfibrozil, dose nke rosuvastatin ekwesịghị gafere 10 mg / ụbọchị.
Ọrịa anaghị eme mgbanwe ọ bụla maka ndị okenye.
Mgbe ị na-atụle usoro ọgwụ pharmacokinetic na ndị ọrịa nke agbụrụ dị iche iche, mmụba nke sistemụ rosuvastatin n'etiti ndị Japan na ndị China. Ekwesiri iburu n'uche eziokwu a mgbe ị na-ede akwụkwọ rosuvastatin na ndị ọrịa a. Eji ọgwụ a na ọgwụ gbadara 40 mg na ndị ọrịa agbụrụ Mongoloid.
Ọrịa enweghị akụrụ
N'ime ndị ọrịa nwere nsogbu gbasara akụrụ dị obere ma ọ bụ na-adịghị agafe agafe, ọ dịghị mkpa ịgbanwe ndozi dose. Ojiji nke ọgwụ Akorta ka ejikọtara n’aka ndị ọrịa nwere nnukwu akụrụ oke (iwepupụta creatinine erughị 30 ml / min).
Eji ọgwụ a were dochie ọgwụ 40 mg na ndị ọrịa nwere obere ọrụ mkpo ya na-arụ ọrụ nke ukwuu (nwechapụ ihe na-erughị 60 ml / min).
Ndị ọrịa nwere ọrịa imeju
Enweghị ahụmịhe banyere iji ọgwụ ahụ eme ihe na ndị ọrịa nwere akara dị elu karịa 9 na ọnụ ọgụgụ Childe-Pugh. A na - enye ọgwụ Akorta ọgwụ na ndị ọrịa nwere ọrịa imeju na mmega ahụ (gụnyere mmụba na-abawanye na ọrụ nke “imeju” transaminases, yana mmụba ọ bụla na ọrụ “imeju” transaminases n'ọbara) karịa ugboro atọ ma e jiri ya tụnyere oke nke kwesịrị.