Proinsulin bụ ihe mbido insulin, nke mkpụrụ ndụ beta nke pancreas na-emepụta ma na-edozi glucose ọbara. A na-ahụta mbelata nke ukwuu na proinsulin n'ụdị ọrịa shuga mellitus nke 1 (ọrịa endocrinological nke e jiri ọkwa shuga dị elu nke elu elu mepụta nzụlite insulin na-akpata).

Nyocha banyere ọdịnaya nke proinsulin n'ọbara na-eme ka o kwe omume ịchọpụta pathologies nke mkpụrụ ndụ beta nke agwaetiti nke Langerhans nwere oke ziri ezi, i.e. ọrịa shuga mellitus, yana oge ya kpebiri mmepe nke steeti mamịrị na insulinoma (endocrine tumo na-ezo insulin).

Ejiri proinsulin n'ime mkpụrụ ndụ beta nke pancreas na-etinye n'ime mkpụrụ akwụkwọ nchekwa pụrụ iche. N'ime ha, n'okpuru ọrụ nke PC1 / 3, PC2 na carboxypeptidase E prohormones, ọ na-agbajikwa n'ime insulin na C-peptide. Naanị ihe ruru pacenti atọ nke proinsulin anaghị ejikọ ya na homonụ ma na-ebugharị n'ụdị n'efu. Agbanyeghị, itinye uche ya na ọbara nwere ike iru 10-30% nke olu nke na - ekesa insulin, ebe ọkara ndụ proinsulin ji okpukpu atọ karịa.

Mara: Ọrụ proinsulin dị okpukpu iri ala karịa insulin. Mana n’agbanyeghi nke a, mmụba na ntinye uche ya na ọbara nwere ike ibute ọnọdụ hypoglycemic (mbelata ọbara shuga dị ala). Mmụba na ọkwa proinsulin na-egosi nsogbu na akụrụ (ezughi oke, dysfunction), imeju (cirrhosis), gland thyroid (hyperthyroidism), wdg.

Ọbara proinsulin nwere ike ịbawanye mgbe ị risịrị nri, yana n'oge mmalite nke ọrịa shuga. Nnukwu nnuku nke proinsulin bụkwa ihe e ji mara usoro arụmọrụ (akpụ mkpụrụ ndụ islet na-egbochi insulin).

N'ọnọdụ ndị a na-adịghị ahụkebe, mkpokọ proinsulin na-abawanye site na mmepụta ezughi oke nke ntụgharị PC1 / 3, enzyme nke usoro endocrine. Ọrịa a na - eduga n'ọgba aghara na nhazi nke homonụ peptide, nke oke ibu, amụghị nwa, ọrịa akụrụ na ọrịa shuga na - etolite.

Ọ dị mma ịmara na ọtụtụ ndị ọrịa nwere ntụgharị ntụgharị nwere ntutu na-acha ọbara ọbara, n'agbanyeghị afọ, okike na agbụrụ.

Ihe ngosi maka nyocha

Edere nnwale proinsulin n'ihe ndị a:

• onodu hypoglycemic, tinyere ndi mmadu mere,
• nchoputa nke neoplasms pancreatic (insulinoma),
• ntule nke oru na akari sitel beta sel,
• mkpebi siri ike nke ntụgharị mgbanwe na ụdị mkpụrụ ndụ nke proinsulin molecule,
• nchọpụta ọrịa dị iche iche nke ọrịa shuga.

Ogwu aria ogwu, oncologist, endocrinologist, gynecologist na pediatrician nwere ike imuta ihe nke proinsulin ule.

Norms nke proinsulin

Ngalaba ọkọlọtọ maka nyocha plasma proinsulin bụ pmol kwa 1 lita ọbara.

Afọ iri na asaa0,7 – 4,3

Mara: ụkpụrụ ntụnye aka nyere bụ naanị maka ule emere na afọ efu.

Asebawanye ueskpụrụ

• Akụkọ banyere ezinụlọ nke hyperproinsulinemia (ọnọdụ proinsulin dị elu na-arịa ọrịa shuga mellitus ma ọ bụ oke ibu),
• 2dị nke abụọ nke ọrịa shuga mellitus (na-abụghị insulin),
• Mmepe nke etuto ahụ na-eme ka mmadụ sie ike (gụnyere insulinomas),
• Ọkpụkpụ endocrine ndị ọzọ nwere ike imepụta insulin.
• Ọrịa dị iche iche nke mkpụrụpụta islet beta,
• Arụrụ nwa na-anaghị ala ala,
• Hyperthyroidism (hyperecretion nke homonụ thyroid),
• Cirrhosis nke imeju (mgbanwe n'ụdị anụ ahụ ya),
• Hypoglycemic hyperinsulinemia (steeti nke nwere nnukwu glucose ịta ahụhụ) n'ụdị siri ike,
• Na-ewere ọgwụ hypoglycemic (gụnyere sulfonylureas),
• Ntughari PC1 3.

Mara: n'ihe karịrị pasent 80 nke ndị ọrịa insulinoma, proinsulin dị elu karịa ka ọ dị. Ọ bụ ya mere uche na nkọwapụta nyocha maka nyocha nke ọrịa a ji bụrụ 75-95%.

Site na imepụta ntụgharị nke ezughi oke, a ga-abawanye proinsulin mgbe nri gachara, a ga-ebelata insulin. Ihe ndi ozo nke homonụ ga-etolite, dịka ọmụmaatụ, obere nzuzo nke cortisol, nnukwu ahụ, uru usoro ọmụmụ.

Nkwadebe nyocha

Ihe omumu banyere ndu: ọbara venous.

Samzọ nlele: venipuncture nke ọnya anụ ahụ dịka ọkọlọtọ algorithm dị.

Oge nlere: 8: 00-10: 00h.

Ọnọdụ nlele: na afo efu (n'oge abalị na-ebu ọnụ, ọbụlagodi awa 10, a na-ahapụ mmiri ọ withoutụ withoutụ na-enweghị gas na nnu).

• N'ụbọchị ikpe a, amachibidoro iri oke abụba, eghe, nri na-egbu egbu, ị drinkụ ihe ọholicụholicụ na-aba n’anya na tonic (ginger tii, kọfị na koko, ume, wdg)
• Daysbọchị 1-2 tupu ule ahụ, ekwesịrị ịhapụ ọnọdụ ndị na-akpata nchekasị, a ga-ahapụ ihe omume egwuregwu, ibu ibu kwesịrị oke,
• Amachibidị ị smokingụ sịga otu awa tupu nyocha (siglịko, vape, hookah),
• Nkeji nkeji iri abụọ ruo iri abụọ tupu mkpachapụ ahụ, ọ dị mkpa ịnọdụ ọdụ ma ọ bụ dina ala, zuru ike, chebe onwe gị pụọ na nrụgide anụ ahụ ọ bụla.

Dị Mkpa! Ọ bụrụ na ị na-anata homonụ ma ọ bụ ọgwụ ọgwụ ndị ọzọ, hụ na ịgwa dọkịta gị aha ha, oge nchịkwa ha na usoro ịsụ ọgwụ gị tupu ịme nyocha proinsulin.

E nwekwara ike kenye gị ọrụ:

Akwukwo

1. Encyclopedia of Clinical Laboratory Tests, Ed. N.U. Ihu. Houselọ obibi akwụkwọ
   "Labinform" - M. - 1997 - 942 p.
2. Z. Ahrat Ali, K. Radebold. - insulinoma. - http://www.emedicine.com/med/topic2677.htm
3. Ngwa nke ụlọ ọrụ - onye na-emepụta ihe dị iche iche.
4. Akwụkwọ Tietz nke kemịkalị na nyocha nke mkpụrụ ndụ (ed. Burtis C., Ashwood E., Bruns D.) - Saunders - 2006 - 2412 p.
   

• Nchoputa nke hypoglycemic ọnọdụ. Nkwụsị nke insulin.
• Nlele arụmọrụ sel nke Pancreatic beta (leekwa anya: insulin (nnwale nke 172) na C-peptide (nnwale n. 148).

Pretkọwapụta nsonaazụ nyocha nwere ozi maka dibịa bekee ọ bụghị nyocha. Enweghi ike iji ozi dị na ngalaba a nyocha nke onwe ya na ịgwọ onwe ya. Dọkịta na-eme nchọpụta ziri ezi site na iji nsonaazụ nyocha a yana ozi ndị dị mkpa site na isi mmalite ndị ọzọ: akụkọ ihe mere eme, nsonaazụ nke nyocha ndị ọzọ, wdg.

Ngalaba nke nha na ụlọ nyocha nke Independent na INVITRO: pmol / l.

Proinsulin

Okwu mmeghe

Proinsulin, homonụ, nke na-ebute insulin, bụ nke a na-arụkọta n’ime sel selganik. N'okpuru ọrụ nke protein, C-peptide na-ekpochapu site na molekul proinsulin ma mepụta insulin na-arụ ọrụ. Dị ka ọ na-adị, ihe fọrọ nke nta ka ọ bụrụ proinsulin niile na-agbanwe ka insulin na-arụ ọrụ. Naanị obere proinsulin ka a na-ahụ n’ọbara. Ọkwa proinsulin n'ọbara na-akọwa ọnọdụ nke mkpụrụ ndụ panc-pancreatic. A na-eji ọkwa nke proinsulin eme ihe na nyocha nke etuto ahụ panc-sel na-akpata. Imirikiti ndị ọrịa insulinomas nwere mmụba na insulin, C-peptide na proinsulin, mana n'ọnọdụ ndị a na-adịghị ahụkebe, naanị mmụba na ọkwa proinsulin ka enwere ike ịhụ. Proinsulin nwere ọrụ ndu dị ala (ihe dịka 1:10) na ogologo ndụ ogologo (ihe dịka 3: 1) karịa insulin. N'agbanyeghị obere ọrụ proinsulin dị ala, mmụba nke ọkwa ya nwere ike ịkpata ọnọdụ hypoglycemic. N'ime mkpụrụ ndụ β-mkpụrụ gbanwere nke ọma, ihe ndị mebere nzuzo na-aga n'ihu proinsulin. Mkpụrụ proinsulin / insulin molar nke insulinomas dị elu karịa 25%, mgbe ụfọdụ ruo 90%. Enwere ike ịbawanye ụba nke proinsulin na ndị ọrịa nwere ọdịda akụrụ, cirrhosis, hyperthyroidism.

Site na mmụba nke proinsulin site na pancreas, dịka ọmụmaatụ, na anụ ahụ na-eguzogide insulin ma ọ bụ n'okpuru mmetụta nke ọgwụ nzuzo na-akpali (dịka ọmụmaatụ, sulfonylureas), ntụgharị nke proinsulin na insulin na-arụ ọrụ na-ezughị ezu, n'ihi ikike dị oke egwu nke nchebe. Nke a na - ebute mmụba nke proinsulin n'ọbara na mbelata mkpokọta insulin na - arụ ọrụ. Maka nke a, enwere ike iwere ịba ụba nke proinsulin n'ime ọbara dịka ihe ama ama nke imebi ọrụ nke mkpụrụ ndụ β.

Proinsulin na Ọrịa shuga 2dị nke Abụọ

Ejiri ụdị ọrịa shuga abụọ nke ọrịa mickitus bụ nke a na-ahụ maka mgbochi anụ ahụ na - egbochi insulin na mmerụ ahụ nke nwere nsogbu. A na-akọwa nnabata insulin dị ka nzaghachi metabolic na-akpata nsogbu insulin ma ọ bụ insulin na-agwụ ike. Nke a bụ nsogbu a na-ahụkarị, achọpụtara na ihe karịrị 50% nke ndị ọrịa nwere ọbara mgbali elu. Ọ na-ahụkarị ndị okenye, mana ọ nwekwara ike ịmalite n’oge nwata. Nchịkwa insulin na-abụkarị ihe a na-amaghị ruo mgbe mmepe nke nsogbu metabolic. Ndị nwere ọbara mgbali elu, oke ibu, dyslipidemia, ma ọ bụ ịnagide glucose na-enwe nsogbu nwere ike ịbawanyewanye na nguzogide insulin. Amabeghị usoro zuru oke maka mmepe nke nguzogide insulin. Ọgba aghara na-eduga na nguzogide insulin nwere ike ime na ọkwa ndị a: prereceptor (insulin na-ezighi ezi), onye na-anabata ya (ibelata ọnụ ọgụgụ ma ọ bụ mmekọrịta nke ndị na-anabata ya), na-ebugharị glucose (ibelata ọnụ ọgụgụ nke mkpụrụ ndụ GLUT4), na postreceptor (ngbanwe mgbapụta na phosphorylation). Ekwenyere na ugbu a na isi ihe kpatara insulin iguzogide bụ nsogbu postreceptor na-ebute mgbasa nke nnyefe insulin.

Proinsulin dị ka ihe dị egwu maka ọrịa obi

Nkuchi nsị na insulin nwere njikọ chiri anya na ọria infarction myocardial, ọrịa strok, na nsogbu ndị ọzọ. Ya mere, nchọpụta nke anụ ahụ na - eguzogide ọgwụ insulin dị ezigbo mkpa. Ruo ugbu a, nchọpụta nke nguzogide insulin bụ naanị enwere ike iji ya rụọ ọrụ dị oke ọnụ. Ọmụmụ nyocha ụlọ ọgwụ n’oge na-adịbeghị anya gosipụtara mkpa nyocha nke proinsulin dịka akara nchọpụta nke insulin na-eguzogide 6, 7.

Mmụba proinsulin na des-31,32-proinsulin (ngwaahịa proinsulin na-akụda) n'ụzọ doro anya na-etinyekwu ihe n'ihe egwu na - ebute arteriosclerosis na ọrịa obi obi. Ruo ugbu a, enweghi otu usoro na-akọwa etu insulin iguzogide ihe na -eme ọnya obi nke sistem. Insulin nwere ike inwe mmetụta na atherogenesis, n'ihi ike ya iji mee ka nkwalite akwara dị n'okpukpu mgbidi yana ịgbatị akụkụ ahụ dị mma nke mgbidi akwara ozi. N'aka nke ọzọ, Atherosclerosis nwere ike ịbụ n'ihi nsogbu ọbara-ọgụ, dị ka ọbara mgbali, nnabata glucose, na dyslipidemia.

Proinsulin dị ka akara nchoputa

Kpebisie ike na ọkwa proinsulin dị iche iche maka amata ọrụ nzuzo nke mkpụrụ ndụ reat-pancreatic. Dabere na ọmụmụ a, enwere ike kpebie usoro ọgwụgwọ ọgwụgwọ ma nyocha nrụpụta ọgwụgwọ.

Nsonaazụ nke nyocha nke proinsulin na ndị ọrịa nwere ọrịa shuga 2

Proinsulin 11.0 pmol / L

(imebi ihe nzuzo nke-sel nke pancreas)

O yikarịrị ka njikọ nke insulin anụ ahụ na-emetụta ya na nsogbu nzuzo. A na-atụ aro ọgwụgwọ maka nguzogide insulin. Site na usoro ọgwụgwọ na-aga nke ọma (mgbe ihe dị ka ọnwa 3), ọkwa nke proinsulin n'ọbara na-ebelata.

Nsonaazụ nke ọmụmụ nke proinsulin na ndị ọrịa nwere ọrịa mellitus

Proinsulin> 11,0 pm / L

A na-atụ aro nyocha iji chọpụta ọrịa shuga maka ọrịa shuga ma ọ bụ insulinoma na ịchọpụta ihe ndị dị ize ndụ maka mmepe nke ọrịa obi.

Ihe ngosiputa maka ebumnuche nke ihe omumu a:

• Nchoputa nke hypoglycemic ọnọdụ
• Insulin na-enyo enyo
• Nyocha ọrụ arụmọrụ Pancreatic β
• Nchoputa nke nguzogide insulin

Mmụba na-egosi:

• Ọrịa shuga IIdị nke Abụọ
• Familia hyperproinsulinemia
• Egwu akwara puru iche (insulinomas)
• Etu insulin na-emepụta
• Ọdịdị nchekwa nzuzo nke β sel ahụ dị
• Nlegide insulin
• Ọkụ akwara afọ n’ala
• Hyperthyroidism
• Cirrhosis
• Nnukwu hypoglycemic hyperinsulinemia
• Nri nke sulfonylureas (ọgwụ hypoglycemic)

Nkwadebe omumu ihe

Enyere ọbara maka nyocha banyere afọ na-adịghị ọcha n'ụtụtụ, a na-ahapụ tii ma ọ bụ kọfị. A na-anabata mmiri ị plainụ mmiri.

Oge etiti oge site na nri ikpeazụ ruo ule ahụ bụ opekata mpe asatọ.

Beforebọchị tupu ọmụmụ ihe ahụ, a takeụla ihe ọholicụ alcoụ na-egbu egbu, nri nwere abụba, amachikwa mmega ahụ.

Ntughari Nsonaazụ

Nkịtị: 0,5 - 3.2 pm / L.

Mmụba:

2. Enweghị ntụgharị nke PC1 / 3.

3. Ọrịa hyperproinsulinemia.

4. Nsogbu akwara gbasara akwara.

5. Pịnye ọrịa shuga 2.

6. Hyperthyroidism - hyperthyroidism.

7. drugsakingara ọgwụ hypoglycemic - usoro nke sulfanylurea.

Mbelata:

1. Type 1 diabetes mellitus (insulin-based).

Họrọ akara ngosi nke na-enye gị nsogbu, zaa ajụjụ ndị a. Chọpụta otú nsogbu gị siruru n’ibu ma ọ bụ ịhụ dọkịta.

Tupu iji ozi ahụ saịtị medportal.org nyere, biko gụọ usoro nkwekọrịta onye ọrụ.

Nkwekọrịta onye ọrụ

Medportal.org na-enye ọrụ n'okpuru usoro akọwapụtara na akwụkwọ a. Amalite iji saịtị Weebụsaịtị, ị kwadoro na ịgụọla usoro nkwekọrịta onye ọrụ a tupu i tinye weebụsaịtị, wee nabata usoro niile nke nkwekọrịta a. Biko ejikwala weebụsaịtị ma ọ bụrụ na ikwenyeghi na usoro ndị a.

Nkọwa ọrụ

Ozi niile ezigara na saịtị a bụ naanị maka ederede, ozi ewepụtara site na isi mmalite bụ maka akwụkwọ ntụgharị abụghị mgbasa ozi. Weebụ intanetị medportal.org na-enye ọrụ nke na-enye Onye ọrụ ohere ịchọ ọgwụ na data nke enwetara n'ụlọ ahịa ọgwụ dị ka akụkụ nke nkwekọrịta n'etiti ndị na-ere ọgwụ na webụsaịtị medportal.org. Maka ịdị mma nke iji saịtị ahụ, a na-ahazi data nke ọgwụ na nri ndị ọzọ ka ọ bụrụ nke mkpokọ otu.

Weebụsaịtị medportal.org na-enye ọrụ na-enye Onye ọrụ ohere ịchọ ụlọ ọgwụ na ozi ọgwụ ndị ọzọ.

Mmachi nke ịkwụ ụgwọ

Ozi edepụtara na nsonaazụ ọchụchọ ahụ abụghị nke a na-enye ọha. Nlekọta nke saịtị medportal.org anaghị ekwe nkwa ido anya, izu ezu na / ma ọ bụ mkpa nke data egosiri. Nchịkwa saịtị ahụ medportal.org abụghị ihe ọjọọ ma ọ bụ mmebi ị nwere ike ịta ahụhụ na ịnweta ma ọ bụ enweghị ike ịbanye na saịtị ma ọ bụ site na iji ma ọ bụ enweghị ike iji saịtị a.

Site na ịnabata usoro nke nkwekọrịta a, ị ghọtara nke ọma ma kwenye na:

Ihe omuma di na saịtị a bu ntughari.

Nlekọta nke saịtị ahụ medportal.org anaghị ekwe nkwa enweghị nke njehie na iche iche gbasara ekwuputara na saịtị ahụ yana nnweta na ọnụahịa maka ngwa ahịa dị na ahịa ọgwụ.

Onye ọrụ ahụ na-eme ihe iji dokwuo anya ozi ndị masịrị ya site na ekwentị kpọọ n'ụlọ ahịa ọgwụ ma ọ bụ jiri ozi enyere na uche ya.

Nlekọta nke saịtị medportal.org anaghị ekwe nkwa enweghị ụkọ na ndagwurugwu gbasara nhazi ụlọ ọgwụ, nkọwa kọntaktị ha - nọmba ekwentị na adresị.

Enweghị nchịkwa saịtị ahụ medportal.org, ma ọ bụ ndị ọzọ na-etinye aka na usoro ịnye ozi nwere ike ịta ahụhụ maka mmebi ma ọ bụ mmebi ị nwere ike ịnata eziokwu ahụ ị tụkwasịrị obi kpamkpam na ozi dị na weebụsaịtị a.

Nlekọta nke saịtị ahụ medportal.org na-eme ma na-agba mbọ iji gbalịsie ike n'ọhụụ iji belata ndịiche na mmejọ na ozi enyere.

Nlekọta nke saịtị ahụ medportal.org anaghị ekwe nkwa enweghị ụkọ ọrụ ọ bụla, gụnyere gbasara arụmọrụ ngwanro ahụ. Nlekọta nke saịtị ahụ medportal.org na-agba mbọ itinye mbọ niile ozugbo enwere ike iwepu ọdịda na mmejọ ọ bụla ma ọ bụrụ na ha mere.

A dọrọ onye ọrụ ahụ aka na ntị na nchịkwa saịtị ahụ medportal.org abụghị maka ileta na iji ihe ndị dị na mpụga, njikọ nke enwere ike ịnwe na saịtị ahụ, anaghị enye nnabata nke ọdịnaya ha, ọ bụghịkwa maka ịdịrị ha.

Nlekọta nke saịtị ahụ medportal.org nwere ikike ịkwụsịtụ ọrụ saịtị ahụ, ma ọ bụ gbanwee ma ọ bụ gbanwee ọdịnaya ya kpamkpam, mee mgbanwe na Nkwekọrịta Onye ọrụ. A na-eme mgbanwe ndị a naanị na uche nke Nchịkwa ahụ na-enweghị ọkwa ọkwa na Onye ọrụ ahụ.

Kwenyere na ịgụla usoro nke Nkwekọrịta Onye Ọrụ a, ma nakwere usoro niile nke nkwekọrịta a zuru ezu.

Ozi mgbasa ozi maka itinye ọnụọgụ ntanetị nke ntanetị nwere nkwekọrịta kwekọrọ na akara mgbasa ozi akara "akara ngosi."

Proinsulin Assay - Nnwale β-Cell

Nnyocha ụlọ nyocha maka nchọpụta, gụnyere ọrịa shuga, na-arụ ọrụ dị mkpa. Ọ bụghị mgbe niile ihe mgbaàmà nke ọrịa ahụ na ọkwa nke glycemia ọbara na-egosipụta ezigbo usoro a na-ahụ anya n'ime ahụ, nke na-eduga na njehie nchọpụta iji guzobe ụdị ọrịa shuga.
Proinsulin bụ ụdị arụ ọrụ nke protein protein nke insulin mepụtara site na mkpụrụ ndụ is-sel nke agwaetiti dị na pancreas n'ime mmadụ. Mgbe ekpochasịrị proinsulin, saịtị protein (nke a makwaara dị ka C-peptide), enwetara insulin, nke na-achịkwa metabolism niile n’ahụ mmadụ, ọkachasị catabolism nke glucose na shuga ndị ọzọ.

A na-echekwa ngwongwo a na sel nke agwaetiti nke Langerhans, ebe ọ na - agbanwe insulin hormone nọ n'ọrụ. Agbanyeghị, ihe dị ka 15% nke ihe ahụ ka na-abanye n'ọbara ọbara agbanwebeghị. Site n’itule ego a, n’ihe banyere C-peptide, mmadụ nwere ike ikpebi ọrụ nke mkpụrụ ndụ and na ike ha imepụta insulin. Proinsulin nwere obere ọrụ catabolic ma dị ogologo ndụ na ahụ mmadụ karịa insulin. Mana, n'agbanyeghị nke a, nnukwu proinsulin (nke a na-ahụ n'oge usoro oncological na pancreas (insulinoma, wdg)) nwere ike ịkpasu hypoglycemia na mmadụ.

Pkwadebe maka nnwale proinsulin

Iji chọpụta ọkwa nke proinsulin n'ime mmadụ, a na-anakọta ọbara venous. Na mbu, onye ọrịa aghaghi iso ọtụtụ ndụmọdụ adịghị mgbagwoju anya, nke jikọtara ha niile na nkwadebe maka nyocha biochemical iji chọpụta ọkwa glucose:

1. A na-enye onyinye ọbara n'ụtụtụ tupu nri ehihie, na afọ efu. A na-ahapụ ya ka ọ were obere mmiri a gụrụ agụ, na-enweghị ihe mgbakwunye.
2. Beforebọchị tupu ọmụmụ ihe ahụ, ọ dị mkpa ịwepụ ihe ọholicụ alcoụ na-egbu egbu, ise anwụrụ, na-emega ahụ ike, yana nchịkwa nke ọgwụ, ma ọ bụrụ na ọ ga-ekwe omume, karịsịa ọgwụ ụfọdụ na-ebelata shuga (glibenclamide, ọrịa shuga, amaryl, wdg).

Ihe ngosi maka nyocha ulo nyocha

A na-eme nyocha maka proinsulin dịka ihe ngosi ahụike siri dị, iji kọwaa eziokwu ndị a:

• Nkọwa nke ihe kpatara ọnọdụ mberede hypoglycemic.
• Amata insulinomas.
• Kpebie ogo ọrụ ọrụ mkpụrụ ndụ akwara a na-eme.
• Kpebie ụdị ọrịa mellitus na-arịa ọrịa shuga (ụdị 1 ma ọ bụ 2).

Proinsulin Assay - Nnwale β-Cell

Otu ihe dị mkpa n’ịchọpụta nchọpụta ziri ezi bụ site n’inyocha ụlọ nyocha. Ihe mgbaàmà nke ọrịa ahụ na shuga ọbara adịghị egosipụtakarị usoro ọrịa dị na anụ ahụ, ị ​​nwere ike ịmehie ụzọ na ịchọpụta ụdị ọrịa shuga.

Proinsulin bụ prohormone (ụdị adịghị ike nke protein protein nke insulin), nke mkpụrụ ndụ beta nke pancreas mmadụ na-emepụta. C - peptide (protein protein) dị ọcha site na proinsulin, a na-emepụta ihe insulin, nke na-edozi metabolism nke ahụ mmadụ, na-etinye aka na mbibi nke glucose na shuga ndị ọzọ.

A gbanwere insulin ahụ na - arụ ọrụ n’ime sel nke agwaetiti nke Langerhans. Mana 15% abanye n'ọbara ọbara n'ụdị mbụ ya. Ọ bụrụ n ’ịha n’ ego nke ihe a, ị ga - ekpebi kedu β - mkpụrụ ndụ nwere ike imepụta insulin. Na proinsulin, a na-ekwukarị ọrụ catabolic, ọ na-enwekwa ike ịnọ n'ahụ ahụ ogologo oge karịa insulin. Ma nnukwu usoro nke ihe a na pancreas (ya na usoro oncological na akụkụ a) nwere ike ịkpasu hypoglycemia na mmadụ.

Nkwadebe tupu nyocha maka pronesulin
A na - anakọta data banyere ọnụọgụ proinsulin n'ime ahụ. Tupu ịtụle nnwale, onye ọrịa na-eso ọtụtụ ndụmọdụ ndị yiri nkwadebe tupu nyocha nke biochemical iji chọpụta ọkwa nke glucose dị n'ọbara:
- A na --ele onyocha ọbara n'ụtụtụ na afọ efu. Enwere ike ị waterụ mmiri dị ọcha na-enweghị ihe mgbakwunye.
- Ruo awa iri abụọ na anọ, a na-ewepụ mmanya na-egbu egbu, ị smokingụ sịga, mgbatị ahụ na mmega ahụ, na-a especiallyụ ọgwụ, ọkachasị ọgwụ na-ebelata shuga dị ka glibenclamide, ọrịa shuga, amaryl, wdg.

Ihe ngosi maka nyocha
Edere nyocha nke dọkịta iji chọpụta ọnọdụ ndị a:
- Ọrịa hypoglycemia na mberede
- Nkọwa nke insulinomas
- eterchọpụta ọrụ nke β-sel nke pancreas
- Amata ụdị ọrịa shuga

Mbibi nke nyocha data
Proinsulin dị na ahụike anaghị agafe 7 pmol / l, a na-ahapụ ihe ndọpụ nke 0,5 - 4 pmol / l, nke ga - ekwe omume n'ihi njehie akụrụngwa.

Site n'ọrịa shuga 1dị nke mbụ, a na-agbada n'ụzọ dị ukwuu n'ọbara proinsulin n'ọbara. Increasedbawanye uru nke ụzọ kwesịrị ịdị na-egosi ụdị ọrịa shuga 2, ọrịa oncology, ọrịa obi, akwara na akụrụ.