MANINIL 3

n'ime karama iko nke PC abụọ. 120, n'ime mkpọ kaadiboodu 1 karama ma ọ bụ na ngwugwu bliri 10 ma ọ bụ 20 PC,, na mkpọ nke kaadiboodu 3 blisters.

n'ime karama iko nke PC abụọ. 120, n'ime mkpọ kaadiboodu 1 karama ma ọ bụ na ngwugwu bliri 10 ma ọ bụ 20 PC,, na mkpọ nke kaadiboodu 3 blisters.

n'ime karama iko nke PC abụọ. 120, n'ime mbadamba kaadiboodu 1 ma ọ bụ na ngwugwu pịrị apị 20,. n'ime mkpọ nke kaadiboodu 1, 2, 3, 4 ma ọ bụ 6 blisters.

Mlọ ọgwụ

Mgbe abanye Maninil 3.5, a ga-ahụta ngwa ngwa ihe fọrọ nke nta ka ọ bụrụ ngari. Nwepụta zuru oke nke ihe dị n'ime microionized dị n'ọrụ na-apụta n'ime nkeji ise.
Nchịkọta protein protein Plasma karịrị 98% maka Maninyl 3,5, 95%.
Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju na ịmalite nke metabolites abụọ na-adịghị arụ ọrụ, otu n'ime akụrụ ya, na nke ọzọ nwere mgbagha.
T1 / 2 maka Maninyl 3,5 bụ awa 1.5-3.5.

Ofzọ nke ngwa

Maninil 3,5 were ọnụ, ụtụtụ na mgbede, tupu nri, na-akọghị ata. A na-etinye dose ahụ iche iche, dabere na ọrịa ahụ.
Usoro izizi bu 1 / 2-1 mbadamba, nkezi bụ 1 mbadamba. kwa ụbọchị, kacha - 3, na enweghị atụ - 4 mbadamba. kwa ụbọchị.
Sesbọchị ọ bụla ruo mbadamba abụọ. a na-ewerekarị otu ugboro (n'ụtụtụ), nke dị elu - kewara n'ime usoro abụọ (n'ụtụtụ na mgbede).

Nsonaazụ

Hypoglycemia ga-ekwe omume (ya na nri iri nri, ịdoụ ọgwụ oke, yana ịba ụba n'ike, yana ị alcoholụbiga mmanya ókè).
Site na ngwe nri: oge ​​ụfọdụ - ọgbụgbọ, ọgbụgbọ, na ụfọdụ - ọrịa cholestatic jaundice, ịba ọcha n'anya.
Site na sistemu hemopoietic: a na - adịghị ahụkebe - thrombocytopenia, granulocytopenia, erythrocytopenia (ruo pancytopenia), n'ọnọdụ ụfọdụ - ọrịa hemolytic.
Mmeghachi omume nfụkasị: nke a na - adịghị ahụkebe - ọnya anụ ahụ, ahụ ọkụ, mgbu nkwonkwo, proteinuria.
Ihe ozo: na nmalite ogwugwo, enwere ogbaaghara ebighi ebi. N'ọnọdụ ndị na-adịghị ahụkebe, eserese.

Ihe ngbanwe

Ihe mgbochi igbochi iji ogwu Maninil 3,5 bụ: hypersensitivity (gụnyere ọgwụ sulfonamide na ọgwụ ndị ọzọ na-akpata sulfonylurea), ụdị ọrịa shuga mellitus 1 (insulin-dependance), metabolic decompensation (ketoacidosis, precoma, coma), steeti mgbe ebubasịrị pancreatic, ọrịa imeju siri ike na akụrụ, ụfọdụ ọnọdụ ọjọọ (dịka ọmụmaatụ, decompensation nke carbohydrate metabolism na ọrịa na-efe efe, ọkụ, mmerụ ahụ ma ọ bụ mgbe a warachara ya mgbe a na - egosipụta ọgwụgwọ insulin), leukopenia, mgbochi nke eriri afọ, jikọtara ọnụ h afo, ọnọdụ tinyere nri na -ewepụta nri yana mmepe nke hypoglycemia, afọ ime na oge inye ara.

Mmekọrịta na ọgwụ ndị ọzọ

Ngkwalite mmetụta hypoglycemic nke ọgwụ Maninil 3,5 enwere ike iji ya mee ihe na ojiji nke ACE inhibitors, ndị na-anabolic na homonụ nwoke na nwanyị, ọgwụ hypoglycemic ndị ọzọ ọnụ (dịka ọmụmaatụ, acarbose, biguanides) na insulin, azapropazone, NSAIDs, beta-blockers, nze quinolone, chloramphenicol, clomofiber, na-enupụ isi, ọgwụ fenfluramine, ọgwụ antifungal (miconazole, fluconazole), fluoxetine, MAO inhibitors, PASK, pentoxifylline (na oke ọnụọgụ maka nchịkwa parenteral iri nri), perhexiline, ihe ndị pyrazolone, phosphamides (dịka ọmụmaatụ cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfonamides, tetracyclines na tritoqualin.
Ndị na-ewepụta acid urine (ammonium chloride, calcium chloride) na-eme ka mmetụta nke Maninyl ọgwụ dịkwuo ike site na ibelata ogo nke dissociation ya na ịba ụba reabsorption.
Hypoglycemic edinam Mannino ọgwụ nwere ike belata mgbe ojiji nke barbiturates, isoniazid, diazoxide, corticosteroids, glucagon nicotinate (elu dose), phenytoin, phenothiazines, rifampicin, thiazide diuretics, acetazolamide, onu gbochie afọ, estrogens, thyroid hormone ọgwụ ọjọọ, sympathomimetic mmadụ, ihe mgbochi nke ọwa kalsal dị nwayọ, nnu nke lithium.
Ndị na-emegide H2 na-anabata ndị na-emegide ihe nwere ike ịkụda, n'otu aka, ma, n'akụkụ nke ọzọ, na-eme ka mmetụta hypoglycemic nke Maninil dị elu.
N’ọnọdụ ndị a na-adịghị ahụkebe, pentamidine nwere ike ibute mbelata ma ọ bụ nwekwuo mgbanye glucose ọbara.
N'iji ọgwụ mee ihe n'otu oge, Maninil nwere ike ịkwalite ma ọ bụ mebie mmetụta nke ọgwụ coumarin.
Yana ịba ụba hypoglycemic edinam, beta-igbochi, clonidine, guanethidine na reserpine, yana ọgwụ nwere usoro ihe eji eme ihe, nwere ike belata mmetụta nke ọrịa hypoglycemia.

Dodoụbiga ya ókè

Site na oganihu nke hypoglycemia, onye ọrịa ahụ nwere ike ịkwụsị njide onwe onye na ịma ya, mmepe nke hypoglycemic coma.
Ọgwụ: n’ihe banyere hypoglycemia dị nro, onye ọrịa ahụ kwesịrị iwere otu shuga, nri ma ọ bụ drinksụọ ihe ọ drinksụ withụ nwere nnukwu shuga (jam, mmanụ a ,ụ, iko tii dị ụtọ) n’ime. N'ihe banyere enweghị uche, ọ dị mkpa ịbanye na glucose iv - 40-80 ml nke 40% dextrose solution (glucose), mgbe ahụ, infusion nke 5-10% dextrose solution. Mgbe ahụ ị nwere ike itinye 1 mg nke glucagon na / na, / m ma ọ bụ s / c. Ọ bụrụ na onye ọrịa ahụ alaghachighi, mara na enwere ike ikwugharị usoro a; ọzọ nwere ike ịchọ ọgwụgwọ siri ike.

Mpempe mwepụta

Maninil 3.5 - mbadamba.
Nkwakọ ngwaahịa - na karama iko nke pcs 120., Na mkpọ nke kaadiboodu n'ime 30 ma ọ bụ 60 PC.

1 mbadamba Maninil 3,5 nwere ihe ndị na-arụ ọrụ: glibenclamide (n'ụdị micronized) 3.5 mg.
Ndị na-ahụ maka ya: lactose monohydrate, stachi nduku, gimetellosa, silloon silikon dioxide, magnesium stearate, crimson dye (Ponso 4R) (E124)

Omume ọgwụ

Ọ nwere nsonji akwara na extrapancreatic. A na-egosipụta ọrụ pcreatic na mkpali nke imepụta insulin site na mkpụrụ ndụ beta nke pancreatic, a na-egosipụta ihe omume extrapancreatic na mmụba nke nnabata insulin na-anabata anụ ahụ (n'ihi nrụgide tyrosine kinase) na insulin, na iwepu gluconeogenesis na glycogenolysis na imeju.

Ọgwụ mlọ Ọgwụ

Mpempe micronized na-enye mmezu mbụ nke C_max , mmekorita nke mmetụta hypoglycemic fọrọ nke nta ka ọ kwekọọ na elu nke postprandial hyperglycemia, nke na -eme ka mmetụta physiological ya jikọtara ya na T dị mkpụmkpụ._1/2 belata ihe ize ndụ nke hypoglycemia. Mkpa kwa ụbọchị maka glibenclamide nwere ike belata site na 30-40%.

Nchedo nchekwa

A na-eji ya akpachara anya ma ọ bụrụ na ọrịa febrile, ọrịa thyroid (na arụ ọrụ na-arụ ọrụ), hypofunction nke ntụgharị ihu ma ọ bụ adrenal cortex, ahoụrụma, na ndị ọrịa agadi n'ihi ike nke ịmalite hypoglycemia. Achọrọ nlekọta ahụike mgbe niile. N'oge ọgwụgwọ, ịkwesịrị ịgbasochi nri. Iwere Maninil anaghị edochi ihe oriri. N'oge ọgwụgwọ, a naghị atụ aro ka ị na-eme ihe ndị chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor, ka ị nọrọ n'anyanwụ ogologo oge. Imeghari otu ọ̀ dị mkpa maka ịghara oke nri anụ ahụ na nke mmetụta uche, mgbanwe nri.

Usoro onunu ogwu na uzo icho ogwu a.

A na-edobe ọgwụ ahụ n'otu n'otu, dabere afọ, ogo nke ọrịa shuga, glycemia na-ebu ọnụ na awa 2 mgbe ị risịrị nri.

Nkezi oge bụ 2.5-15 mg / ụbọchị, ugboro nchịkwa ya bụ ugboro 1-3 / ụbọchị. Were minit 20-30 tupu nri. Na usoro onunu ihe kariri 15 mg / ubochi, a na-eji ya mee ihe na oge adighi adighi eme ka mmụba dị ukwuu na mmetụta hypoglycemic.

Maka ndị ọrịa agadi, ọgwụ mbụ bụ 1 mg / ụbọchị.

Mgbe ị na-agbanwe site na biguanides, ọgwụ mbụ nke glibenclamide bụ 2.5 mg / ụbọchị. Biguanides kwesiri ka ewepu ya, na onodu glibenclamide, ma oburu na odi nkpa, nwe ike ijeri 2.5 mg kwa ubochi 5-6 iji kwusi mmebi nke metabolism. Na enweghị ụgwọ maka izu isii na isii, ọ dị mkpa ịhazi usoro ọgwụgwọ na glibenclamide na biguanides.

Nsonaazụ Maninil 3.5:

Site na usoro endocrine: hypoglycemia ruo coma (ohere nke mmepe ya na-abawanye site na imebi usoro dosing na nri adịghị mma).

Mmeghachi omume nfụkasị: ọnya anụ ahụ, itching.

Site na usoro digestive: ọgbụgbọ, afọ ọsịsa, mmetụta nke oke na mpaghara epigastric, adịkarịghị - ọrụ imeju na - arụ ọrụ, cholestasis.

Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: ọ na - adịkarịghị - paresis, nsogbu uche, isi ọwụwa, ike ọgwụgwụ, adịghị ike, ike ọgwụgwụ.

Site na usoro hematopoietic: adịkarịghị - ọgba aghara hematopoiesis ruo n'ọrịa pancytopenia.

Mmeghachi omume udiri oria: na adighi ike - photoensitivity.

Ntụziaka pụrụ iche maka iji Maninil 3.5.

A na-eji nlezianya mee ya na ndị ọrịa na-arịa ọrịa akwara na akụrụ (gụnyere akụkọ ihe mere eme), yana ahụ ọkụ, ọrụ isi ike, gland thyroid, na ahoụrụma na-egbu egbu.

N'oge usoro ọgwụgwọ, ịdị na-achọpụta glucose ọbara kwa mgbe na mwepu glucose kwa ụbọchị dị mkpa.

Site na mmepe nke hypoglycemia, ọ bụrụ na onye ọrịa maara, a na-edenye glucose (ma ọ bụ ihe ngwọta shuga) n'ime. Ọ bụrụ na mmụọ amaghị, a na-edozi glucose intravenous ma ọ bụ glucagon sc, intramuscularly ma ọ bụ intraven. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere carbohydrates iji zere ịmaliteghachi hypoglycemia.

Ndị ọrịa na-a gụ mmanya glibenclamide kwesịrị izere ị drinkingụ mmanya. N'ihe banyere ị alcoholụ mmanya, mmepe nke disulfiram dịka mmeghachi omume, yana nnukwu hypoglycemia, ga-ekwe omume.

Nmekorita nke Maninil 3.5 na ogwu ndi ozo.

Ngkwalite mmetụta hypoglycemic nke glibenclamide ga-ekwe omume na ojiji nke beta-blockers, ndị na-anabolic, allopurinol, cimetidine, clofibrate, cyclophosphamide, isobarin, MAO inhibitors, sulfonamides nke na-arụ ọrụ ogologo oge, salicylates, chloramphenicol, tetracycline, ethane.

Ike mmeghari nke glibenclamide na mmepe nke hyperglycemia ga-ekwe omume site na iji ya mee ihe nke barbiturates, chlorpromazine, phenothiazines, phenytoin, diazoxide, acetazolamide, glucocorticoids, sympathomimetikal, glucagon, indomethacin, nchịkwa oncosis, nchịkwa oncosis, nchịkwa oncosis, nchịkwa oncosis, nchịkwa oncosis doses dị ukwuu nke laxatives.