Telsartan (40 mg) Telmisartan > Ọgwụgwọ na mgbochi

Mbadamba 40 mg, 80 mg

Otu mbadamba ihe

ike ihe - telmisartan 40 ma ọ bụ 80 mg, karị,

ndị mbụ: meglumine, sodium hydroxide, povidone (PVP K 30), mannitol, magnesium stearate, mmiri

Mbadamba 40 mg - mbadamba ihe site na ọcha ruo na acha ọcha, nke nwere mkpuchi “T” na “L” na akụkụ dị n'akụkụ yana “40” n'akụkụ nke ọzọ.

Mbadamba 80 mg - mbadamba ihe site na ọcha ruo na acha ọcha, nke nwere akpụ akpụ nwere “T” na “L” yana ebe dị anya n'otu akụkụ yana “80” n'akụkụ nke ọzọ.

Ngwongwo ogwu

Mlọ ọgwụ

A na-etinye Telmisartan ngwa ngwa, ego a na-etinye na-agbanwe. Na bioavailability nke telmisartan dị ihe dị ka 50%.

Mgbe ị na-ewere telmisartan n'otu oge na nri, mbelata na AUC (mpaghara n'okpuru oge ịta ahụhụ) sitere na 6% (na dose 40 mg) ruo 19% (na dose 160 mg). Mgbe awa 3 a malitesịrị ịbanye n'ọbara plasma ọbara, ọ gụpụrụ nri. Mbelata nke obere na AUC anaghị eduga n'ịbelata ọgwụgwọ ọgwụgwọ.

Enwere ọdịiche na mkpokọta plasma na ụmụ nwoke na ụmụ nwanyị. Cmax (ntinye uche kacha ukwuu) na AUC dị ihe dịka ugboro atọ na ugboro abụọ karịa nke ụmụ nwanyị ma e jiri ya tụnyere ụmụ nwoke enweghị nnukwu mmetụta na arụmọrụ.

Nkwukọrịta na protein plasma karịa 99.5%, tumadi na albumin na alfa-1 glycoprotein. Olu nke nkesa dị ihe dị ka lita 500.

A na-agunye Telmisartan site na ịjikọta ihe mmalite na glucuronide. Onweghi ọgwụ ogwu nke conjugate a hụrụ.

Telmisartan nwere ụdị ihe dị na ụlọ ọgwụ ọgwụ nwere obere mkpochapu ọkara ndụ> awa iri abụọ. Cmax na - ruo obere pere mpe - AUC na-abawanye ihe a na-ezighi ezi na ọnụego ya. Onweghi otutu mkpocha egwu telmisartan achoputara.

Mgbe nchịkwa onu gachara, a na-ekepụta telmisartan kpamkpam site na eriri afọ na-agbanweghị. Mkpopụta urinary na-erughị 2% nke dose. Mkpokọta plasma zuru oke (ihe dị ka 900 ml / min) ma e jiri ya tụnyere ọbara ọbara ịba ọcha n'anya (ihe dị ka 1500 ml / min).

Ndị okenye na-arịa ọrịa

A na-agbanwe ọgwụ ọgwụ nke telmisartan na ndị ọrịa agadi.

Ndị ọrịa nwere akụrụ

N'ime ndị ọrịa nwere ọrịa akụrụ na -agide ọrịa metụtara akwara, a na-ahụta ọkwa plasma dị ala. N'ime ndị ọrịa nwere akụrụngwa akwara, telmisartan nwere ihe jikọrọ ya na protein protein na-apụtaghị ihe n'oge a na-ahụ ya. Na ọdịda akụrụngwa, ọkara ndụ anaghị agbanwe.

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere oke ịba ọcha n'anya, bioavailability zuru oke nke telmisartan na-abawanye na 100%. Ndụ ọkara nke imeju anaghị agbanwe agbanwe.

A na-enyocha ọgwụ ọgwụ onjections abụọ nke telmisartan na ndị ọrịa nwere ọbara mgbali (n = 57) dị afọ 6 ruo 18 mgbe ị na-ewere telmisartan na usoro 1 mg / kg ma ọ bụ 2 mg / n'arọ maka oge izu anọ. Nsonaazụ nke ọmụmụ a gosipụtara na ọgwụ ọgwụ nke telmisartan na ụmụaka na-erubeghị afọ iri na abụọ kwekọrọ na ndị okenye na, ọkachasị, ekwenyeghi agwa Cmax abụghị linear.

Mlọ ọgwụ

Telsartan® bụ ezigbo antiotensin II nnabata antagonensin II (ụdị AT1) maka nchịkwa ọnụ. Telmisartan nwere ezigbo mmekọrịta na-achụpụ angiotensin II site na saịtị ya jikọtara ọnụ na ndị nnabata nke AT1, nke na-ahụ maka mmetụta amaara nke angiotensin II. Telmisartan enweghị mmetụta agonist na AT1 receptor. Telmisartan ahọrọla maka ndị nnabata AT1. Njikọ ahụ na-aga n'ihu. Telmisartan egosighi ịdị ka ibe ya maka ndị nnabata ndị ọzọ, gụnyere ndị nnabata AT2 na ndị ọzọ, ndị na-anabataghị ndị na-anabata AT.

Amamịghe ọrụ nke ndị nnabata ndị a, yana nsonaazụ nke ike ha nwere na angiotensin nke abụọ, amụchaghị nke na-abawanye na nhọpụta nke telmisartan.

Telmisartan na-ebelata ọkwa Plasma aldosterone, anaghị egbochi renin na plasma na ion nke mmadụ.

Telmisartan anaghị egbochi enzyme angiotensin na-agbanwe (kinase II), nke na-emebi bradykinin. Yabụ, enweghị nkwanye ugwu nke mmetụta ọ bụla metụtara ihe bradykinin.

N'ime mmadụ, ọnụọgụ 80 mg nke telmisartan fọrọ nke nta ka ọ na-egbochi mmụba nke ọbara mgbali (BP) nke angiotensin II kpatara. A na-ejikwa mmetụta inhibitory ihe karịrị awa 24 ma a ka kpebisiri ike mgbe awa 48 gasịrị.

Ọgwụ nke ọbara mgbali elu dị mkpa

Mgbe ị takingụsịrị ọgwụ mbụ nke telmisartan, ọbara mgbali na-ebelata mgbe awa 3 gachara. A na - enweta nwayọ na mbelata ọbara mgbali elu karịa izu anọ mgbe ebidochara ọgwụgwọ a ga - ejikwa ya ogologo oge.

Mmetụta antihypertensive na-ewe awa 24 mgbe ị theụsịrị ọgwụ ahụ, gụnyere 4 awa tupu ị doseụ ọgwụ ọzọ, nke gosipụtara site na nha ọbara mgbali ọbara, yana nkwụsi ike (karịa 80%) nke kacha nta na oke nke ọgwụ ahụ mgbe ịghasịrị 40 na 80 mg nke Telsartan® na njikwa ọnwụnwa ụlọ ọgwụ.

N'ime ndị ọrịa nwere ọbara mgbali elu, Telsartan® na -ebelata ma ọpụpụ ọbara systolic na diastolic na-enweghị ịgbanwe obi.

Ejiri mmetụta antihypertensive nke telmisartan na ndị nnọchianya nke klas ndị ọzọ nke ọgwụ antihypertensive, dị ka: amlodipine, atenolol, enalapril, hydrochlorothiazide, losartan, lisinopril, ramipril na valsartan.

N'ihe banyere ịkagbu telmisartan na mberede, ọbara mgbali ji nwayọọ nwayọọ na-alaghachikwute ụkpụrụ ahụ tupu a gwọọ ya ọtụtụ ụbọchị na-enweghị ihe ịrịba ama nke ịmaliteghachi ọbara mgbali elu ngwa ngwa (enweghị ọrịa nloghachi ọzọ).

Ihe omumu ihe omumu gosiputara na Telemisartan nwere mmekorita di egwu na mkpirisi onu ogugu nke aka ekpe na ventricular mass.

Ndị ọrịa nwere ọbara mgbali elu na nephropathy na-arịa ọrịa shuga na-agwọ ọrịa na Telsartan® na-egosi mbelata ọnụ ọgụgụ proteinuria (gụnyere microalbuminuria na macroalbuminuria).

Na ule nyocha ụlọ ọgwụ multicenter mba dị iche iche, e gosipụtara na ọ dị obere ikpe ọnya akọrọ na ndị ọrịa na-ewere telmisartan karịa ndị ọrịa na-anata angiotensin-na-emegharị enzyme inhibitors (ACE inhibitors).

Mgbochi ọrịa obi na onwu

N'ime ndị ọrịa afọ iri ise na ise gbagotere ọrịa akwara akwara, ọrịa strok, ọrịa akụkụ, ma ọ bụ ọrịa mellitus nwere mmerụ ahụ (retinopathy, hypertrophy ekpe, macro na microalbuminuria), ojiji nke Telsartan® na-ebelata ọnọdụ nke infarction myocardial, strok, ọrịa n'ụlọ ọgwụ maka ọrịa obi ọgụ ma belata onwu site na ọrịa obi.

A na-enyocha mmetụta antihypertensive nke telmisartan na ndị ọrịa nwere ọbara mgbali afọ dị ka afọ 6 ruo afọ 18 (n = 76) mgbe ha nwesịrị telmisartan na ọgwụ nke 1 mg / kg (mesoo n = 30) ma ọ bụ 2 mg / n'arọ (mesoo n = 31) maka usoro ọgwụgwọ izu anọ. .

Systolic ọbara mgbali (SBP) na nkezi belatara site na uru mbụ site na 8.5 mm Hg na 3.6 mm Hg. n'ime otu telmisartan, 2 mg / kg na 1 mg / n'arọ, otu. Diastolic ọbara mgbali (DBP) na nkezi belatara site na uru mbụ site na 4.5 mmHg. na 4.8 mmHg n'ime otu telmisartan, 1 mg / kg na 2 mg / kg, n'otu n'otu.

Mgbanwe ndị ahụ dabere na ha

Ejiri nchekwa nchekwa ahụ na nke ndị ọrịa okenye.

Usoro onunu ogwu na nhazi

A na-eche mbadamba Telmisartan maka nchịkwa ọnụ kwa ụbọchị ma were ya mmiri, yana nri ma ọ bụ na-enweghị nri.

Ọgwụ nke ọbara mgbali elu dị mkpa

Ọgwụ okenye a tụrụ aro ya bụ 40 mg otu ugboro kwa ụbọchị.

N'ọnọdụ ebe ọbara na-achọ ihe na-adịghị mma, enwere ike ịbawanye ọnụọgụ nke Telsartan® ruo 80 mg ugboro otu ugboro n'ụbọchị.

Mgbe ị na-abawanye ọgwụ, ekwesịrị iburu n’obi na a ga - enwekarị ọgwụ antihypertensive n’etiti izu anọ ma ọ bụ asatọ mgbe ịmalitere ọgwụgwọ.

Enwere ike iji Telsartan® mee ya na thiazide diuretics, dịka ọmụmaatụ, hydrochlorothiazide, nke jikọtara na telmisartan nwere mmetụta hypotensive ọzọ.

N'ime ndị ọrịa nwere nnukwu ọbara ọgbụgba, ọnụọgụ nke telmisartan bụ 160 mg / ụbọchị (mbadamba abụọ nke Telsartan® 80 mg) yana mgbakwunye hydrochlorothiazide 12.5-25 mg / ụbọchị nke ọma anabata ma dị irè.

Mgbochi ọrịa obi na onwu

Ọgwụ a tụrụ aro bụ mgmita iri asatọ kwa ụbọchị.

Ekpebibeghị ya ma usoro ọgwụ dị n'okpuru 80 mg dị irè iji belata ọrịa obi na ọnwụ.

Na nmalite mmalite nke iji ọgwụ ọgwụ Telsartan® maka igbochi ọrịa obi na ọrịa, ọ na-atụ aro ijikwa ọbara mgbali (BP), ọ nwekwara ike ịdị mkpa iji dozie ọbara ọgbụgba na ọgwụ ndị na-ebelata ọbara mgbali elu.

Enwere ike iburu Telsartan® n'agbanyeghị agbanye nri.

Achọghị mgbanwe mgbanwe nke oge a na ndị ọrịa nwere ọrịa akụrụ, gụnyere ndị ọrịa n'ọrịa metụtara akwara ụkwụ. Enweghi ahụmịhe n’ịgwọ ndị ọrịa nwere nnukwu akụrụ gbasara akwara na usoro ịba uru. Maka ndị ọrịa dị otú a, a na-atụ aro ịmalite site na obere ọgwụ nke 20 mg. A naghị ewepụ Telsartan® n'ọbara n'oge ọbara ọgbụgba.

N'ime ndị ọrịa nwere nsogbu imeju dị nro ma ọ bụ nke na-adịghị ala ala, ọgwụ kwa ụbọchị ekwesịghị ịkarị 40 mg otu ugboro n'ụbọchị.

Dose ukpụhọde adịghị.

Nsonaazụ

Na ọnwụnwa ndị na-achịkwa placebo na ndị ọrịa nwere ọbara mgbali elu, ọnụọgụ nke nsonaazụ ndị a kọrọ na telmisartan (41.4%) na-abụkarị atụnyere ọnụ ọgụgụ nsonaazụ ndị a na-eme na placebo (43.9%). Onu ogugu ndi a abughi uzo dabere na ya, o nweghi ihe gbasara nwoke na nwoke, afọ, ma obu agbụrụ ndi ọrịa.

Profaịlụ nchekwa nke telmisartan na ndị ọrịa na-a theụ ọgwụ maka mgbochi nke ọrịa obi na ọnwụ nke kwekọrọ na profaịlụ nchekwa maka ndị ọrịa nwere ọbara mgbali elu.

Nsonaazụ ndị edepụtara n'okpuru ka enwetara n'ihi nnwale ụlọ ọgwụ na-achịkwa ebe ndị ọrịa nwere ọbara mgbali keere òkè, yana ọmụmụ ọmụmụ azụmaahịa. Na mgbakwunye, a kọọrọ mmetụta dị egwu na mmetụta ndị butere ịkwụsị ọgwụ ahụ, nke a kọrọ na nnwale ọgwụgwọ ogologo oge atọ metụtara ndị ọrịa 21,642 bụ ndị weere telmisartan iji gbochie ọrịa obi na ọnwụ na afọ isii.

Edere ihe ojoo dị n'okpuru ebe a site na iji nhazi ọkwa ndị a: ọtụtụ mgbe ≥1 / 100 ruo

Mwepụta wepụtara ya na ihe mejupụtara

A na-ahapụ ọgwụ ahụ n'ụdị nke mbadamba ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha. N’otu akụkụ mkpụrụ ọgwụ dị n’ihe ize ndụ.

N'ime otu mbadamba, Telmisartan nwere ike ịbụ 40 mg ma ọ bụ 80 mg nke otu ihe eji arụ ọrụ. Ndi ozo bu sodium hydroxide, meglumine, povidone, magnesium stearate, hydroxypropyl methylcellulose, mannitol.

Omume ọgwụ

Telmisartan bụ onye na-emegide angiotensin nke 2. Ọ nwere ezigbo ọgwụ mmekọrịta ya na Amlodipine, yabụ, ha na-ejikọ onwe ha. Odika awa 2,5-3 mgbe ị theụsịrị ọgwụ, a na-achọpụta mbelata ọbara mgbali elu. Mbelata kachasị na nsonaazụ ya na-apụta izu 4 mgbe usoro ọgwụgwọ gasịrị.

Site na mbelata nke nrụgide, ọgwụ a enweghị mmetụta ọ bụla na ọnụego obi na ọnọdụ akwara akwara. Naanị diastolic na ọbara mgbali systolic na-ekpughe mmetụta ọgwụ. Nke a bụ otu njirimara nke ihe eji arụ ọrụ.

Ntụziaka maka ojiji

Telmisartan na-ejigide ọbara mgbali n'ime oke kwesịrị. Ntuziaka maka iji kọwaa ka eji mbadamba ihe n'agbanyeghị nri nri. Na-a wholeụ mmiri na-enweghị nkpu. Jiri obere mmiri sachaa ya. A naghị atụ aro ị withụ mmiri ọ juụ juụ, karịsịa mkpụrụ vaịn, ebe ọ na-eme ka mmetụta ọgwụ ahụ sikwuo ike.

Ogo kachasị mma kwa ụbọchị adịghị karịa 40 mg. Mmetụta nke ọgwụ ahụ na-adịgide ruo ma ọ dịkarịa ala awa 24. Ọ na-amalite ime ihe mgbe awa 1.5 gachara. Ogwu kachasị bu 80 mg. Mana enwere nsogbu imeju, a na-ahapụ ya ị drinkụ ihe karịrị 40 mg kwa ụbọchị.

N'iji ya mee ihe mgbe niile maka otu ọnwa, nrụgide nrụgide na-ekwe nkwa njirimara ndị dị mkpa.

Mgbe ejikọtara ya na ndị na - egbochi ACE, ọgwụ ndị na-enye potassium na ọgwụ ndị nwere potassium, njikwa oke dote dị mkpa. Ọgwụ nwere ike ibute hyperkalemia. Na mgbakwunye, ọ na-akwalite mmụba nke lithium na dioxin n'ime ọbara.

Telmisartan maka ọgwụgwọ ọbara mgbali elu

A na-edenyekarị 40 mg kwa ụbọchị. Ma enwere ike belata dose ahụ ruo 20 mg ma ọ bụrụ na ọgwụ ahụ dị mma na usoro onunu ogwu ahụ.

Ọ bụrụ na ịnweghị ike iji ọgwụ 40 kwa ụbọchị nweta ihe ịchọrọ iji nweta ya, ị nwere ike ịbawanye ya, ma ruo ihe dịka 80 mg. A na-ewere ọgwụ ahụ dum otu oge. Mgbe ị na-ekpebi idozi usoro onunu ogwu, ọ dị mkpa iburu n’obi na arụpụtaghị oke n ’ọ ozugbo, mana ihe dị ka ọnwa 1-2 nke mbadamba mbido.

Iji belata ọbara mgbali, a na-enyekarị Telmisartan otu oge na thiazide diuretics.

Telmisartan maka ndọtị ndụ na ọrịa obi

A chọpụtara na arụmọrụ nke Telmisartan maka igbochi ọnwụ na ndị mmadụ na-arịa ọrịa nke usoro akwara ọbara na usoro ọgwụ nke 80 mg kwa ụbọchị. Amaghị ma ihe a chọpụtara na-akpata ya na obere doses amaghị.

Ọ bụrụ n’inwere nsogbu akụrụ ma ọ bụ imeju, i kwesiri ijide n’aka na usoro ọgwụ a anaghị akpata nsonaazụ n’akụkụ akụkụ ndị a. Ọ dị mma ịmalite ntụtụ nke 20 mg kwa ụbọchị. Maka ọtụtụ ndị ọrịa nwere ọrịa imeju na-arụ ọrụ, ọgwụ karịrị 40 mg kwa ụbọchị dị ize ndụ.

Gụọkwa akụkọ a: Lercanidipine: 10 mg na mbadamba 20 mg

Ihe ngbanwe

Edebeghi Telmisartan n'okwu ikpe ndị a:

anaraghi aru nkpuru nke aru.
imebi ikike nke biliary tract,
ime na lactation
ụmụaka na ndị na-eto eto (ruo afọ 18),
hypersensitivity na mmiri,
oké ịba ọcha n'anya na akụrụ odida,
mmụba nke homonụ aldosterone - Conn syndrome, nke mmepe nke usoro tumo na akwara adrenal,
glucose-galactose malabsorption.

Ndị mmadụ na-arịa ọrịa obi, akụrụ afọ ma ọ bụ ọnya afọ, na-enwekarị ọbara ọgbụgba, ọ dị mkpa ịtụle oge ịgụta ọbara oge ma gee ntị na mmetụta ha.

Dọkịta ga-enyocha ọnọdụ ndị ọrịa iji gbochie nsogbu.

Nsonaazụ

Mgbe ị na-a aụ ọgwụ, ụfọdụ mmetụta ọ bụla nwere ike ịdapụta, gụnyere mmepe nke ọrịa mbupu azụ mgbe ejiri ya:

ụkwara na-adịghị ala ala
myalgia
ọgbụgbọ na ọgbụgbọ
bloating
hypercreatininemia,
pharyngitis
isi ọwụwa
isi ike,
arthralgia
anya ntughari
ọrịa na ahụ erughị ala na mpaghara lumbar,
anaemia
ụba ọrụ nke hepatic transaminases,
ọbara mgbali elu,
ụba oke iwe
ọnọdụ ịda mba
afọ ọsịsa ma ọ bụ afọ ntachi
akpụkpọ anụ?
ọzịza nke ngụgụ
Udeme nke Quincke (nke adịkarịghị),
nsogbu ịrahụ ụra
rashes,
wedata na haemoglobin na plasma ọbara,
obi mgbu
arrhythmia na tachycardia.

Ntụziaka pụrụ iche

Ekwesịrị ịkpachara anya na ndị ọrịa na-anya ụgbọala ma ọ bụ ndị ọrụ ha chọrọ nlebara anya ka ukwuu, ebe otu n'ime ihe ndị ọzọ ọ na-akpata bụ ọgbụgba.

Ọ dị mkpa ileba anya na mgbanwe dị na ọkwa electrolyte, BCC, nlezianya nlebara anya banyere ọnọdụ ndị ọrịa nwere nsogbu imeju ma ọ bụ akụrụngwa ma ọ bụ nwee akwara akụrụ, stenosis nke aorta ma ọ bụ mitral valve nke obi, igbochi ọbara mgbali elu hyphrorophic, nkụchi obi na-adịghị ala ala, ọrịa obi obi. ọnyá afọ, ọbara ọgbụgba ma ọ bụ ebupute ọbara.

Mkparịta ụka ọgwụ ọjọọ

Ọ bụrụ na ị Telụọ Telmisartan 80 mg ma ọ bụ 40 mg na Digoxin, mgbe ahụ ịta nke ikpeazụ na ọbara ga-abawanye. N'otu oge ahụ, ị theụ ọgwụ a kọwara n'elu na ọgwụ ndị na-egbu potassium anaghị atụ aro ya. Nlekọta oge nke Telmisartan na NSAIDs (otu aspirin) na-ebelata nsonaazụ, ebe nrụgide ụba na onye ọrịa na-ebelata.

Tel na-ewere Telmisartan ọgwụ ndị ọzọ na-ebelata ọbara mgbali elu, ị nwere ike nweta mbelata nke ọbara mgbali na ọkwa oke egbu. Yabụ, ọ ka mma ịghara ị typesụ ọtụtụ ọgwụ ọgwụ otu oge, ebumnuche nke ya bụ iweta ọbara mgbali nkịtị.

Ọ bụrụ na ị na-a Telụ Telmisartan 40 ma ọ bụ 80 n'otu oge na corticosteroids, nke a ga-ebelata mmetụta antihypertensive (ibelata nrụgide).

Analogs nke Telmisartan

Ihe owuwu na-ekpebi analogues:

Ndị na-emegide Angiotensin 2 na-emegide analogues:

Valsacor
Candecor
Lorista
Izar
Karzartan
Cardosal
Irbesartan
Olimestra
Gụrụ
Mikardis Gụnyere,
Ibertan
Atacand
Valz
Aha ya bụ Valsartan
Hyposart,
Cardostin
Lozarel
Cozaar
Zisakar
Nortian
Telsartan
Diovan
Tantordio
Naviten
Tanidol
Xarten
Telzap
Vasotens,
Telmista
Ngọngọ
Ordiss
Losacor
Lotor
Nkọwapụta
Edarby
Losartan
Telmisartan
Lozap,
Cardosten
Tareg
Aprovel
Valsafors,
Ochichi
Itinye
Firmast
Lakea
Presartan,
Candesartan
Sartavel
Angiakand.

Weputara udi ya na ihe mebere ya

Ọgwụ bụ mbadamba oval na-acha ọcha na-enweghị shei, convex n'akụkụ abụọ ya. N'ime akụkụ dị elu na nke ọ bụla n'ime ha, enwere ihe ize ndụ maka ịdị mma nke mmebi yana leta "T", "L", na akụkụ ala - ọnụ ọgụgụ "40". N'ime, ị nwere ike ịhụ akwa abụọ: otu bụ pinkish na agba nke ike dị iche iche, nke ọzọ fọrọ nke nta ka ọ bụrụ ọcha, mgbe ụfọdụ enwere obere nsị.

Na mbadamba 1 nke ọgwụ ejikọtara ọnụ - 40 mg nke isi ihe na-arụ ọrụ nke telmisartan na 12.5 mg nke hydrochlorothiazide diuretic.

A na-ejikwa ihe enyemaka:

mannitol
lactose (mmiri ara ehi)
povidone
meglumine
stereta magnesium,
sodium hydroxide
polysorbate 80,
iteghete E172.

Na mbadamba 1 nke ọgwụ ejikọtara ọnụ - 40 mg nke isi ihe na-arụ ọrụ nke telmisartan na 12.5 mg nke hydrochlorothiazide diuretic.

Mbadamba 6, 7 ma ọ bụ 10 PC. etinye ya na blisters nke mebere aluminom foil na ihe nkiri polymer. Enyere ya na igbe kaadi 2, 3 ma ọ bụ 4 blisters.

Mlọ ọgwụ

Nchikota nke telmisartan na hydrochlorothiazide anaghị agbanwe ọgwụ ọgwụ nke ihe ndị ahụ. Ha ngụkọta bioavailability bụ 40-60%. Ngwaọrụ nọ n'ọrụ nke ọgwụ ahụ na-agbadakwa ngwa ngwa. Mkpokọta kachasị nke telmisartan na-abanye na plasma ọbara mgbe awa 1-5,5 dịkarịsịrị ala ugboro abụọ n'ime ụmụ nwoke. Ọkpụkpụ metabolism na-eme na imeju, a na-apụtakarị ihe a na feces. A na - ewepụ Hydrochlorothiazide n'ahụ ihe fọrọ nke nta ka ọ bụrụ na mmamịrị agbanwebeghị.

Ihe ngosi maka ojiji

na usoro ọgwụgwọ ọbara mgbali elu na nke sekọndrị, mgbe ọgwụgwọ ya na telmisartan ma ọ bụ hydrochlorothiazide naanị anaghị enye nsonaazụ achọrọ,
iji gbochie nsogbu ọrịa ọrịa siri ike na ndị okenye karịa afọ iri ise na ise-60,
iji gbochie nsogbu ndị ọrịa nwere ụdị shuga II (na-abụghị insulin) mebiri akụkụ ahụ nke ọrịa na-akpata.

Jiri n'oge ime na lactation

Ime

A machiri ọgwụ a maka ụmụ nwanyị dị ime ma ọ bụ ụmụ nwanyị na-eme atụmatụ ime. Ọ bụrụ na ekwenyela ime n'oge a, a ga-akwụsị iji ya, ma ọ bụrụ na ọ dị mkpa, were ọgwụ ọzọ akwadoro maka iji ụmụ nwanyị dị ime (lee mpaghara “Contraindications” na “Akụkụ ojiji”).
Enweghị data dị mkpa maka ojiji nke Telmisartan maka ụmụ nwanyị dị ime.

Ihe ndabere nke oria ojoo nke ihe egwu teratogenicity n'ihi ihe ACE inhibitors n’oge onwa ato nke ime apughi ime obi uto, mana enweghi ike iwelie ihe nwute. Ọ bụ ezie na enweghị akara ọrịa na-achịkwa nke ọrịa teratogenicity nwere ndị na-emegide angiotensin II antagonens, ihe ize ndụ yiri ya nwere ike ịdị na klas a.

Ekwesighi ịmalite ndị na-emegide ihe nnabata Angiotensin II n'oge afọ ime. Ọ bụrụ na a ka na-eleba anya na usoro ọgwụgwọ na antagonensin II antagonists ka ọ dị mkpa, yana onye ọrịa ahụ na-eme atụmatụ ịtụrụ ime, a na-atụ aro ka iji dochie usoro ọgwụgwọ antihypertensive na profaịlụ nchekwa nchekwa n'oge ịtụrụ ime. Ọ bụrụ na akwadobe afọ ime, a ga-akwụsị ịgwọ ndị ọrịa antiotensin II ozugbo ọ kwesịrị ịmalite usoro ọgwụgwọ ọzọ kwesịrị ekwesị.

A maara na iji angiotensin II antagonists antagonists n'oge oghe nke II na III nke afọ ime na-akpata fetotoxicity na mmadụ (arụ ọrụ na-arụ ọrụ nke arụ ọrụ, oligohydramniosis, oge na-egbu oge nke ọkpụkpụ cranial) na nsonye obi na-egbu egbu (akwara renal, hypotension, hyperkalemia). Ọ bụrụ na ojiji nke angiotensin II receagonor antagonists bidoro n’oge ọnwa nke abụọ nke afọ ime, a na-atụ aro ka ọ nyochaa akụrụngwa nke akụrụ na ọkpụkpụ nke okpokoro isi nke nwa ebu n’afọ. Ekwesịrị iji nlezianya nyochaa ọnọdụ ụmụ amụrụ ọhụrụ ndị nne ha nwetara nnabata antiotensin II (lee ngalaba “Contraindications” na “Akụkụ eji”).

Ara.

A naghị akwado Telmisartan n'oge inye nwa ara, ebe ọ bụ na amabeghị ma mmiri ara ehi ya. Usoro ọgwụgwọ ọzọ ejiri profaịlụ nchekwa nke ọma ka amachara, ọkachasị mgbe ị na-enye nwa amụrụ ọhụrụ ma ọ bụ nwa.

Dodoụbiga ya ókè

Ihe omuma banyere oke ị doụbiga ọgwụ ike n’ime mmadụ nwere oke.

Ọrịa A na-akọpụtakwa mmetụta kachasị dị oke mma nke njupụta nke telmisartan hypotension na tachycardia, na bradycardia, dizziness, na-abawanye ọgwụ ọbara, na oke gbasara akụrụ oke.

Ọgwụgwọ. Achọpụtaghị Telmisartan n'oge usoro ọgwụgwọ hemodial. Ekwesịrị inyocha ndị ọrịa anya na usoro ọgwụgwọ na usoro nkwado. Ọgwụgwọ dabere na oge gafere mgbe ị theụsịrị oke ọgwụ yana ogo mgbaàmà ya. Ihe usoro atumatu gunyere inabata vomiting na / ma obu gastric lavage. Carbon a na-arụ ọrụ nwere ike ịba uru na ọgwụgwọ nke ịdoụbiga mmanya ókè. Mgbe nile lelee serum electrolytes na ọkwa creatinine. Ọ bụrụ na onye ọrịa ahụ nwere hypotension, ọ kwesịrị ịnwe ọkaibe, ọ dịkwa mkpa ịmalite ngwa ngwa iji weghachite nguzo nke mmiri na electrolytes.