Pentilin ọgwụ a: ntuziaka maka ojiji

N'ime, n'oge ma ọ bụ mgbe nri gasịrị, na-elo ihe niile, 400 mg 2-3 ugboro n'ụbọchị, N'ezie - ọbụlagodi izu asatọ.

N'ime / nbanye ma ọ bụ na ntụtụ: 50-100 mg / ụbọchị (na nnu) maka minit 5. Na / n'ime ma ọ bụ na / a infusion: 100-400 mg / ụbọchị (na saline physiological), oge nke infusion intravenous - 90-180 nkeji, na / a - 10-30 nkeji, kacha kwa ụbọchị 800 na 1200 mg, karị. Ntinye aka na - aga n'ihu - 0.6 mg / kg / h maka awa 24, ọnụọgụ kachasị kwa ụbọchị nke 1200 mg.

Na Cl creatinine erughị 10 ml / min, a na-ebelata dose ahụ site na 50-70%. Maka ndị ọrịa na usoro ịba ọcha n'anya, ọgwụgwọ na-amalite site na iji ọgwụ mg mg 400 / ụbọchị, nke a na-abawanye na nkịtị na obere oge dịkarịa ala 4.

Mwepụta wepụtara ya na ihe mejupụtara

• azịza maka nchịkwa intravenous na intravenia: transperent, na-enweghị odo ma ọ bụ nke na-acha odo odo na agba (5 ml na ampoules, ampoules 5 na blister ma ọ bụ plastik, 1 ọnya ma ọ bụ tray na ngwakọ kaadiboodu),
• mbadamba nkume ogologo oge, ihe nkiri na-ete: oval, biconvex, ọcha (pc 10. na ọnya, na mkpọ kaadi nke abụọ blisters).

Ngwakọta nke 1 ampoule nke pentilin solution (5 ml):

• ihe na-arụ ọrụ: pentoxifylline - 100 mg,
• ihe ndi ozo: sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, disodium edetate, mmiri maka injection.

Ngwakọta nke 1 mbadamba pentilin:

• ihe na-arụ ọrụ: pentoxifylline - 400 mg,
• ihe ndi ozo: magnesium stearate, hypromellose, macrogol 6000, silicon dioxide anhydrous colloidal,
• shei: hypromellose, macrogol 6000, talc, titanium dioxide E171.

Mlọ ọgwụ

Pentoxifylline - ihe na-arụ ọrụ nke Pentilin - ọgwụ antispasmodic sitere na purine na-eme ka ihe ndị na-egbu egbu kwụsịlata (ịgbali mmiri) na microcirculation ọbara. Usoro nke ị theụ ọgwụ ahụ bụ n'ihi ikike ya igbochi phosphodiesterase ma nwekwuo mkpali nke cyclic AMP na platelet na ATP na mkpụrụ ndụ ọbara uhie, ebe ike zuru oke, n'ihi nsị vasodilation na-agbadata, ngụkọta akwara vaskụla na-ebelata, ngụgụ na nkeji olu ọbara na-abawanye, ebe ọnụọgụ obi adịghị nke ukwuu. na-agbanwe.

Pentoxifylline dilates na akwara akwara akwara, nke na-eme ka nnyefe oxygen na myocardium (mmetụta antianginal), yana arịa ọbara nke ngụgụ, na-eme ka ikuku oxygenation ọbara.

Ọgwụ a na -eme ka ụda nke akwara nke akụkụ iku ume, ọkachasị diaphragm na mọbụ intercostal.

Ọ na - eme ka microcirculation ọbara dị na mpaghara ndị nwere nsogbu mgbasa, na - eme ka ụdọ nke erythrocyte akpụkpọ ahụ dịkwuo ala, belata viscosity ọbara.

Site na ọnya na-enweghị ike ịpụta akwara ozi (ụkwara ụfụ), Pentilin na-eme ka ije ije dịkwuo ogologo, na-ewepụ nkwonkwo abalị nke uru ahụ nwa ehi na mgbu.

Mlọ ọgwụ

Pentoxifylline bụ metabolized n'ụba sel ọbara yana imeju. Mgbe nchịkwa ọnụ gasịrị, ọ na-ezucha oke kpamkpam site na eriri afọ. Thedị mbadamba ahụ agbatịwo ogologo oge na-enye nkwupụta nke ọgwụ ahụ na ntinye otu.

Pentoxifylline na-enyocha ụzọ isi site na imeju, na-arụpụta metabolites abụọ na-arụ ọrụ na-arụ ọrụ: 1-3-carboxypropyl-3,7-dimethylxanthine (metabolite V) na 1-5-hydroxyhexyl-3,7-dimethylxanthine (metabolite I), plasma ịta nke bụ 8 na 5 ugboro elu karịa pentoxifylline, otu.

Pentoxifylline na metabolites ya ejighi na protein plasma.

Ọgwụ n'ụdị ahụ agbagotere karịa ịta ya n'ime awa 2-4. A na-ekesa ya n'otu oge. Oge iwepu ọkara ndụ bụ awa 0,5-1.5.

Ndụ ọkara nke pentoxifylline mgbe usoro ọgwụ nke 100 mg dị ihe dịka awa 1.1. O nwere oke olu nkesa (mgbe 30 nkeji 30 mg - 168 L) mebere ya, yana nhichapụ dị elu (4500-5100 ml / min).

Ihe dị ka 94% nke ọgwụ enyerela ya bụ akụrụ ya n'ụdị metabolites (ọkachasị metabolite V), ihe dịka 4% - site na eriri afọ. N'okwu a, ihe ruru 90% nke ọgwụ a kapịrị n’ime ọnwa anọ ndị mbụ. Mwepu nke metabolites na-eji nwayọ nwayọ na ndị ọrịa nwere ezigbo akụrụ. N'ihe banyere ọrụ imeju na-emebi emebi, ọkara nke pentoxifylline na-adị ogologo ma na bioavailability ya na-abawanye.

Pentoxifylline dị na mmiri ara ara.

Ihe ngosi maka ojiji

• ntị ntị nke vaskụla sitere,
• ọrịa ụkọ akwara na - adịghị ala ala na akwara ozi na - adịghị ala ala na retina na choroid,
• ọrịa ụbụrụ nke na-adịghị ala ala nke ọrịa ischemic sitere,
• na-emechi obdarteritis,
• nsogbu nsogbu mgbasa n'ihi ọrịa atherosclerosis, ọrịa shuga mellitus (ọrịa shuga),
• angiopathy (paresthesia, ọrịa Raynaud),
• ọnya anụ ahụ trophic ọnya n'ihi ọrịa ara ma ọ bụ microcirculation akwara ike (frostbite, post-thrombophlebitis syndrome, ọnya trophic, gangrene),
• diskirekized na enherosclerotic encephalopathies.

Ihe ngbanwe

• ọbara ọgbụgba n'ụbụrụ,
• mbufụt,
• nnukwu ọbara ọgbụgba
• nnukwu ọnya ọgbụgba,
• oké arrhythmias,
• achịkwa ọbara ọgbụgba,
• nnukwu myocardial infarction,
• oke ọnya atherosclerotic ọnya nke akwara ọbara ma ọ bụ akwara akwara,
• porfria
• afọ ime, lactation,
• afọ ruo afọ 18
• hypersensitivity na mmiri Pentilin ma ọ bụ methylxanthines ndị ọzọ.

• hypotension akwara,
• ike ọgwụgwụ nke obi
• arụ ọrụ na-arụ ọrụ na-arụ ọrụ (mwepụta nke creatinine n'okpuru 30 ml / min),
• nnukwu ọrịa imeju,
• mmụba nke ọbara ọgbụgba, gụnyere mgbe a na-eji ọgwụ anticoagulants, nsogbu nke ọbara coagulation ọbara, mgbe emesịrị ịwa ahụ na nso nso a,
• ọnya afọ nke afọ na duodenum maka mbadamba.

Ngwọta maka ntụtụ

N'ime ụdị edozi, a na-achịkwa Pentilin ma ọ bụ intraarterially.

Dọkịta na-ekpebi ụzọ nchịkwa na oke ọgwụ dị mma maka onye ọrịa ọ bụla, dabere ogo nsogbu ọbara yana nnagide pentoxifylline. A na-ebuo infusion intravenous n'ọkwa supine.

Dịka iwu, maka ndị ọrịa okenye, a na-a drugụ ọgwụ ahụ ugboro abụọ n'ụbọchị (n'ụtụtụ na n'ehihie), 200 mg (2 ampoules nke 5 ml ọ bụla) ma ọ bụ 300 mg (3 ampoules nke 5 ml ọ bụla) na 250 ma ọ bụ 500 ml nke 0.9% sodium chloride solution. ma ọ bụ usoro azịza. A ga-enyocha ndakọrịta na ngwọta infusion ndị ọzọ iche, mana ọ bụ naanị azịza doro anya ga-eji.

Ogologo oge nke infusion bụ opekata mpe 60 maka otu pentoxifylline 100 mg. Nnukwu mpịakọta nwere ike belata ọnụnọ nke ọrịa concomitant, dịka ọmụmaatụ, nkụchi obi. N'ụdị ndị a, ọ bara uru iji ihe enyemaka pụrụ iche jikwaa infusion.

Mgbe irighiri ihe dị otu ụbọchị, ọ bụrụ na ọ dị mkpa, a na-enye mbadamba pentilin 400 mg na ntinye ọzọ - PC abụọ Ọ bụrụ na-eme ihe abụọ ka ọ bụrụ oge dị ogologo, mgbe ahụ, ị ​​nwere ike ibute mbadamba 1 n'isi (ihe dị ka elekere iri na abụọ nke ehihie).

N'ọnọdụ ebe enwere ike ịme ọgwụ mgbochi ọrịa n'ihi ọrịa ọnọdụ naanị otu ugboro n'ụbọchị, nchịkwa ndị ọzọ nke Pentilin na mbadamba na pcs atọ. (Mbadamba nkume abụọ n’etiti ehihie, 1 n’uhuruchi).

N'okwu ndị siri ike, dịka ọmụmaatụ, ya na gangrene, ọnya trophic nke III - IV dị ka nhazi nke Fontaine - Lerish - Pokrovsky, mgbu dị ukwuu na izu ike, a na-egosipụta njikwa ọgwụ ogologo oge - maka awa 24.

Nrọ ndị a tụrụ aro maka nchịkwa intraarterial: na mmalite ọgwụgwọ - 100 mg nke pentoxifylline na 50-100 ml nke 0.9% sodium chloride solution, na ụbọchị ndị na-eso ya - 100-400 mg na 50-100 ml nke 0.9% sodium chloride solution. Ọnụego nchịkwa bụ 10 mg / nkeji, oge nchịkwa bụ 10-30 nkeji.

N'ehihie, ịnwere ike ịbanye ọgwụ ahụ na ọgwụ ruru ihe ruru 1200 mg. N'okwu a, enwere ike ịgbakọ otu onye ahụ dabere na usoro ndị a: 0.6 mg nke pentoxifylline kwa kilogram nke ahụ dị otu awa. Ya mere, ubochi obula kwesiri ibu 1000 mg maka onye ọrịa nwere aru di 70 kilogram, 1150 mg maka onye nwere oria di 80 kg.

Ndị ọrịa nwere ọdịda akụrụngwa, dabere na ntachi obi nke ọgwụ ahụ, belata dose ahụ site na 30-50%.

A choro mbelata mmịpụta na ndị ọrịa nwere ọrụ imeju na-arụ ọrụ nke ukwuu, ebe Pentilin na-anabata ntinye onwe ya.

A na-atụ aro ịmalite ọgwụgwọ na obere doses na mmụba nwayọ nwayọ na ndị ọrịa nwere ọbara mgbali ala, yana na ndị ọrịa na-enwekarị ike ọbara mgbali elu (dịka ọmụmaatụ, na ọrịa obi obi siri ike, akụrụngwa dị n'ọbara akwara dị n'ọbara).

Ekwesịrị iji ọnụ pentilin 400 mg mee ọnụ, mgbe ị risịrị nri: loda mmiri ma drinkụọ mmiri dị ukwuu.

Usoro akwadoro bụ mbadamba mbadamba abụọ ma ọ bụ ugboro atọ kwa ụbọchị. Agaferela otu ọgwụ kwa ụbọchị nke 1200 mg.

Ndị ọrịa nwere akụrụ gbasara akwara na-adịghị ala ala (nwechara nke creatinine)

Mpempe usoro onunu ogwu

Mkpụrụ mbadamba ọgwụ mkpuchi 400 mg

Otu mbadamba ihe

ike - pentoxifylline 400 mg,

ndị na-ebu ụzọ: hypromellose, macrogol 6000, magnesium stearate, sịlịkọn dioxide colloidal anhydrous,

ihe mejupụtara shei: hypromellose, macrogol 6000, titanium dioxide (E 171), talc.

Mbadamba ụrọ dị mma nke nwere biconvex elu, nke mkpuchi ya na-acha ọcha

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, pentoxifylline na-abanye ngwa ngwa ma zuru oke. Bioavailability nke pentoxifylline mbadamba ogologo oge dị ihe dịka 20%. Iri nri na-egbu oge, ma ogaghi ebechachaa oke ogwu.

Oke plasma ịta nwere bụ n'ime awa 2 ruo 4. Pentoxifylline dị na mmiri ara ara, achọpụtara n'ime elekere 2 mgbe nchịkwa gachara, na abụọ - agbanweghị agbanwe na ụdị metabolites.

Pentoxifylline bụ metabolized n'ime imeju yana obere obere sel sel ọbara. Ọ na - eme metabolism dị egwu ma doo anya na mbụ. Ihe ndọtị Plasma nke metabolites na-arụ ọrụ bụ 5 na oge 8 karịa nke ịta pentoxifylline. Ọ bụ metabolized site na mgbochi (site na α-keto reductase) yana ọxịdọrọ.

Metabolites na-abụkarị sọks na mmamịrị (ihe dị ka 95%). Ihe dị ka 4% nke ọgwụ a isụrụ na-apụta site na feces. N'ime nnukwu akụrụngwa akwara siri ike, a na-eji nwayọ ahụ efelata. Site n'ọrịa ịba ọcha n'anya, ọkara ndụ ahụ dị ogologo ma bioavailability na-abawanye. N'akụkụ a, iji zere mkpo ọgwụ na ahụ nke ndị ọrịa dị otú a, a ga-ebelata dose ahụ.

Mlọ ọgwụ

Pentoxifylline na - eme ka ogo dị na ọbara dị ọcha site na-emetụta nrụrụ nke sel ọbara ọbara, na - egbochi nchịkọta platelet ma belata viscosity ọbara na - arịwanye elu. Usoro nke pentoxifylline iji meziwanye ogo rheological nke ọbara gụnyere mmụba nke mkpụrụ ndụ ọbara uhie na ọkwa nke ATP (adenosine triphosphate), cAMP (cyclo-adenosine monophosphate) na cyclic nucleotides ndị ọzọ. Pentoxifylline belata viscosity nke plasma na ọbara site na ibelata mkpokọta fibrinogen. Mbelata nke ịta fibrinogen bụ nsonaazụ nke ọrụ fibrinolytic yana mbelata njikọta ya. Na mgbakwunye, site na igbochi enzymes membrane mechiri phosphodiesterase (nke na-eduga na mmụba nke cAMP) na njikọta nke thromboxane, pentoxifylline na-egbochi ike na ntinye platelet na n'otu oge ahụ na-akpali njikọta nke prostacyclin (prostaglandin I2).

Pentoxifylline belata mmepụta interleukin na monocytes na macrophages, nke na-ebelata ogo mmeghachi omume mbufụt. Pentoxifylline na-emeziwanye akụkụ ụbara na akụkụ ụbụrụ nke ọbara, na-eme ka akwara ndị ọzọ dabere na akwara oxygen na akwara nke ụsọ akwara na -akpata ọnya ụbụrụ, na cobex na akụkụ ụbụrụ, n'ime akwara nke ndị ọrịa nwere ọrịa retinopathy.

Nsonaazụ

Ihe ndị a bụ ọnọdụ nke mmeghachi omume ojoo mere n'oge ọnwụnwa nke ụlọ ọgwụ yana n'oge azụmaahịa.
Si na akuko obi. Arrhythmia, tachycardia, angina pectoris, mbelata ọbara mgbali elu, mgbali ọbara.
Site na sisitemu (ọbara) yana usoro ọbara. Thrombocytopenia, thrombocytopenic purpura, anaemia aplastic (nkebi ma ọ bụ akwụsịchaa otu ụbara ọbara), pancytopenia, nke nwere ike igbu mmadụ.
Site na sistemụ ụjọ. Dizziness, isi ọwụwa, aseptic meningitis, ịma jijiji, paresthesias, cramps.
Site na eriri afọ. Iwe na-egbu mmụọ, mmetụta nke afọ n’ime afọ, flatulence, ọgbụgbọ, vomiting, ma ọ bụ afọ ọsịsa.
N’akụkụ anụ ahụ na akwara dị n’okpuru ala. Itching, redness nke akpụkpọ ahụ na urticaria, necrolysis na-egbu egbu na Stevens-Johnson syndrome.
Mmebi nke ọrụ vaskụla. Sensation nke ikpo ọkụ (ọkụ na-enwu ọkụ), ọbara ọgbụgba, edema ọgụ.
Site na usoro ahụ ji alụso ọrịa ọgụ. Mmeghachi anaphylactic, mmeghachi omume anaphylactoid, angioedema, bronchospasm na ujolactic jijiji.
N’akụkụ imeju na akwara. Cholestasis intrahepatic.
Ọrịa uche Arousal, nsogbu na-ehi ụra, hallucinations.
Site n'akụkụ akụkụ ahụ nile nke ọhụụ. Ọrịa anya, nkwonkwo, ọbara ọgbụgba, mkpochi azụ.
Ndị ọzọ. A kọwo na ọrịa hypoglycemia, ọsụsọ oke, na ahụ ọkụ.

Ime

Enweghị ahụmịhe zuru ezu na ọgwụ ahụ Pentiline womenmụ nwanyị dị ime. Ya mere, a naghị atụ aro ka ọ dee Pentilin n'oge ime.
Pentoxifylline dị obere na-abanye n'ime mmiri ara. Ọ bụrụ na enyere Pentilin iwu, kwụsị inye ara.

Mmekọrịta na ọgwụ ndị ọzọ

Enwere ike ịkwalite mmetụta nke iwetulata shuga dị n’ọbara insulin ma ọ bụ nke ndị na-alụso ọrịa ọgụ ọgụ. Ya mere, ndị ọrịa na-anata ọgwụ maka ọrịa shuga kwesịrị ka akpachapụ anya nyochawa.
N’oge azụmaahịa ahụ, a kọrọ banyere okwu gbasara ike anticoagulant n’ime ndị ọrịa a na-ejikwa pentoxifylline na ọgwụ nje n’otu oge n’otu ọgwụ ma ọ bụ gbanwee, a na-atụ aro inyocha ọrụ anticoagulant n’otu ndị ọrịa.
Pentiline nwere ike ịkwalite mmetụta antihypertensive nke ọgwụ antihypertensive na ọgwụ ndị ọzọ, nke nwere ike ibute mbelata ọbara mgbali elu.
Ojiji nke pentoxifylline na theophylline n’otu oge n’ime ụfọdụ ndị ọrịa nwere ike ibute mmụba na ọkwa theophylline n’ọbara. Ya mere, enwere ike ịbawanye ugboro na ịba ụba na ngosipụta nke mmeghachi omume ọjọọ nke theophylline.
Ketorolac, meloxicam.
Ojiji nke pentoxifylline na ketorolac n'otu oge nwere ike ibute mmụba na oge prothrombin ma mee ka ohere ọbara ọgbụgba dịkwuo elu. Ihe ọghọm nke ọbara ọgbụgba nwekwara ike ịbawanye elu site na iji pentoxifylline na n'otu oge. Ya mere, a na-atụ aro ka ịme ọgwụgwọ n'otu oge na ọgwụ ndị a.

Dodoụbiga ya ókè

Ihe mgbaàmà mbụ nke oke nnyefere Pentiline bụ ọgbụgbọ, dizziness, tachycardia, ma ọ bụ mgbali ọbara na-ebelata.Na mgbakwunye, mgbaàmà ndị dị ka ahụ ọkụ, mgbakasị ahụ, mmetụta nke ọkụ (ọkụ ọkụ), mwepu nke mmụọ, Areflexia, ọdịdọ tonic-clonic na ọgbụgbọ na agba nke kọfị nwekwara ike ịmalite dị ka ihe ịrịba ama nke ọbara ọgbụgba.
Ọgwụgwọ. Iji na-agwọ oke ịdoụbiga ọgwụ ókè na iji gbochie ọrịa, nsogbu a na-ahụ maka nlekọta ahụike n'ozuzu ya na ịkwado nke usoro ọgwụgwọ dị mkpa.

Njirimara ngwa

Na akara mbụ nke mmeghachi omume anaphylactic / anaphylactoid, a ga-akwụsị ịgwọ pentoxifylline ma chọọ ndụmọdụ ahụike.

Ọ dị mkpa nlezianya nlebara anya maka ahụike maka ndị ọrịa nwere ọrịa arrhythmias, hypotension, ọrịa obi na akwara na ndị nwere nkụchi obi ma ọ bụ ịwa ahụ.

N'ihe banyere pentoxifylline, ndị ọrịa nwere nkụda mmụọ na-adịghị ala ala kwesịrị ibu ụzọ ruo mgbe a ga-akwụghachi ụgwọ ọbara na-akwụ ụgwọ.

Maka ndị ọrịa nwere system lupus erythematosus (SLE) ma ọ bụ ọrịa anụ ahụ ejikọtara ọnụ, enwere ike ịkọwa pentoxifylline naanị mgbe nyochachara nke ọma ihe ọghọm na uru dị na ya.

N'ihi ihe ize ndụ nke ọbara ọgbụgba site na iji otu oge pentoxifylline na ọgwụ anticoagulants, nlezianya nlebara anya na nlebara anya ugboro ugboro maka oke ọbara ọbara (MES nke mba ụwa (MES)) dị mkpa.

Ebe ọ bụ na enwere nsogbu ịba n'ọbara anaemia n'oge eji pentoxifylline ọgwụgwọ, ọ dị mkpa ka ị na-elebara ọnụ ọgụgụ ọbara n'ozuzu ya anya.

N'ime ndị ọrịa na-arịa ọrịa shuga ma na-anata insulin ma ọ bụ ọnụ hypoglycemic na-elekọta mmadụ, site na iji nnukwu pentoxifylline, enwere ike ịbawanye mmetụta nke ọgwụ ndị a na shuga ọbara (lee Nkebi “Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ”).

N'ime ndị ọrịa nwere ọdịda akụrụngwa (mwepụ nke creatinine erughị 30 ml / min) ma ọ bụ nnukwu nsị imeju, pentoxifylline excretion nwere ike gbue oge. Ọ dị mkpa ileba anya nke ọma.

Ọrịa daa ọrịa gbasara akụrụ. N'ime ndị ọrịa nwere akwara ezumike (mwepụ nke creatinine erughị 30 ml / min), titition nke doses ruru 50-70% nke ọkọlọtọ kwesịrị ka eburu n'uche nnabata nke mmadụ, dịka ọmụmaatụ, iji pentoxifylline 400 mg ugboro abụọ kwa ụbọchị kama 400 mg ugboro atọ n'ụbọchị.

Oria ndi nwere nnukwu imeju. N'ime ndị ọrịa nwere nnukwu ọrịa imeju, dọkịta ga-eme mkpebi iji belata ọgwụ ahụ, na-eburu ogo ọrịa ahụ na ntachi obi na onye ọrịa ọ bụla.

Kpachara anya nlebara anya dị mkpa maka:

• ndị ọrịa na-arịa ọrịa obi ọgụ arrhythmias,
• ndị ọrịa nwere myocardial infarction
• ndị ọrịa nwere hypotension,
• ndị ọrịa nwere nnukwu atherosclerosis nke akụkụ ụbụrụ na akwara ọbara, ọkachasị mgbe enwere obara mgbali akwara na akwara arrhythmias. N'ime ndị ọrịa a, n'iji ọgwụ ọgwụ, ọgụ angina, arrhythmias na ọbara mgbali elu nwere ike,
• ndị ọrịa nwere ọdịda akụrụngwa (mwepụ nke creatinine dị n'okpuru 30 ml / min.),
• ndị ọrịa nwere nnukwu umeji,
• ndị ọrịa nwere oke ọbara ọgbụgba n'ihi ọmụmaatụ, iji ọgwụgwọ anticoagulants ma ọ bụ nkwarụ ọbara na -akpata. Maka ọbara ọgbụgba - lee mpaghara "Contraindications",
• ndị ọrịa nwere akụkọ ọnya afọ na ọnya afọ, ndị ọrịa nwetere ọgwụgwọ ịwa ahụ n'oge na-adịbeghị anya (ịba ụba nke ọbara ọgbụgba, nke chọrọ nlebara anya usoro ọbara na ọkwa ọbara).
• ndị ọrịa a na - agwọkwa ọgwụ na pentoxifylline na vitamin K n'otu oge (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ”),
• ndị ọrịa na-anata ọgwụgwọ n'otu oge na pentoxifylline na ndị ọrụ hypoglycemic (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ na ụdị mmekọrịta ndị ọzọ”).

Jiri n'oge ime na lactation

Ebe ọ bụ na enwebeghị ahụmịhe eji pentoxifylline dị n’ime ụmụ nwanyị dị ime, ekwesighi ịkọ ya n’oge atụrụ ime.

N'oge a na-enye nwa ara, pentoxifylline na-abanye na mmiri ara. Agbanyeghị, obere nwa a na-enweta obere nwa. Ya mere, o yighị ka ojiji nke pentoxifylline mgbe a na-a duringụ ara na-egosi na ọ nwere mmetụta ụfọdụ na nwa ahụ.

Ikike iji metụta ọnụego mmeghachi omume mgbe ị na-anya ụgbọ ala ma ọ bụ usoro ndị ọzọ

Pentilin enweghị obere mmetụta na ịnya ụgbọ ala na ihe ndị ọzọ. Agbanyeghị, na ụfọdụ ndị ọrịa ọ nwere ike ibute ọgbụgba, yabụ, na -ebelata ike psychophysical ikike ịkwọ ụgbọala na usoro ndị ọzọ. Ruo mgbe ndị ọrịa achọpụtala etu ha si emeghachi omume na ọgwụgwọ, a daghị ha ọdụ ka ha kwọọ ụgbọ ma ọ bụ jiri usoro ndị ọzọ rụọ ọrụ.