Diabeton MV 60 mg: ntuziaka maka ojiji

Oral hypoglycemic ọgwụ sitere na otu nke usoro sulfonylurea nke ọgbọ nke abụọ.
Nkwadebe: DIABETON® MV
Ọrụ umi nke ogwu: gliclazide
Ihe nzuzo ATX: A10BB09
KFG: Ọgwụ ọgwụ hypoglycemic
Nọmba ndebanye: P Nke 011940/01
Ofbọchị idebanye aha: 12.29.06
Ndi nwe reg. doc.: Les Laboratoires Ọrụ

Ntọhapụ wepụtara Diabeton mv, nchịkọta ọgwụ na ihe mejupụtara.

Mbadamba ndị a gbanwere wepụtara na-acha ọcha, na-acha uhie uhie, nwere ihe osise na akụkụ abụọ: na otu bụ akara nke ụlọ ọrụ ahụ, na nke ọzọ - DIA30.

Taabụ 1
gliclazide
30 mg

Ndị na-ahụ maka ihe: calcium hydrogen phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide.

30 PC - blisters (1) - ngwugwu nke kaadiboodu.
30 PC - blisters (2) - ngwugwu nke kaadiboodu.

Nkọwa ọgwụ a sitere na ntuziaka masịrị iwu maka iji ya eme ihe.

Ogwu ogwu di mamma mv

Ọgwụ hypoglycemic ọgwụ sitere na otu nke usoro sulfonylurea nke ọgbọ nke abụọ, nke dị iche na ọgwụ ndị yiri ya site na ọnụnọ nke N-nwere heterocyclic nke nwere N-ejikọ ya na njikọ nke endocyclic.

Diabeton MB na-ebelata glucose ọbara site na-akpali mkpụrụ ndụ nke insulin site na sel Langerhans islet. Mgbe afọ 2 gasịrị ọgwụgwọ, ọtụtụ ndị ọrịa adịghị azụlite ọgwụ ahụ (ọnụọgụ insulin na postprandial insulin na nzuzo nke C-peptides ka dị).

Na ụdị ọrịa shuga mellitus nke 2 (nke na-abụghị insulin), ọgwụ ahụ na-eweghachite mmalite insulin nke nzuzo na nzaghachi glucose ma na-eme ka akụkụ nke abụọ nke insulin kwụsị. A na-ahụta mmụba dị ukwuu na mmiri insulin na nzaghachi mkpali n'ihi nri nri na nchịkwa glucose.

Gliclazide nwere nsonaazụ extrapancreatic, i.e. na - eme ka uru ahụ mmadụ dị na insulin na-abawanye ike.

Na akwara anụ ahụ, ihe insulin na-eme n’arụ glucose, n’ihi mmelite n’ọhụụ nke akwara anụ ahụ na insulin, na-abawanye ụba (+ 35%). Mmetụta a nke gliclazide bụ n'ihi eziokwu na ọ na-akwalite ọrụ nke insulin na muscle glycogen synthetase ma na-eme mgbanwe mgbanwe post-transcriptal na GLUT4 n'ihe metụtara glucose.

Diabeton MB na-ebelata ike ịmịkọ glucose n'imeju, na-eburu ogo glucose ọnụ ọnụ.

Na mgbakwunye na nsonaazụ ya na metabolism metabolism, gliclazide na-eme ka microcirculation dịkwuo mma. Ọgwụ ahụ na-ebelata ihe ize ndụ nke thrombosis obere arịa ọbara, na-emetụta usoro 2 nke nwere ike itinye aka na mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na-eme ka platelet rụọ ọrụ (beta-thromboglobulin, thromboxane B2), yana mweghachi nke fibrinolytic vaskụla endothelial ọrụ na ụba ọrụ nke plasminogen anụ ahụ.

Gliclazide nwere ihe ndị na-egbochi antioxidant: ọ na-ebelata ọkwa nke peroxides lipid na plasma, na-abawanye ọrụ nke sel ọbara ọbara superoxide dismutase.

Pharmacokinetics nke ọgwụ.

Mgbu na nkesa

Mgbe ị takingụsịrị ọgwụ ahụ n'ime ya, gliclazide na-abanye kpamkpam na ngọngọ nri. Theta gliclazide na plasma na-abawanye nwayọ nwayọ, na-erute ala dị larịị awa 6-12 mgbe nchịkwa gasịrị. Iri nri anaghị emetụta ogo nke mmịpụta. Onweghi ike n’otu n’otu di ala. Mmekọrịta dị n'etiti ị theụ ọgwụ na ịta plasma nke ọgwụ bụ ihe ndabere oge.

Otu ụzọ kwa ụbọchị nke Diabeton MB 30 mg na-enye nsị plasma dị irè nke glycazide ruo ihe karịrị awa 24.

Ijikọ protein protein Plasma bụ 95%.

Gliclazide bụ metabolized nke ukwu na imeju. Metabolites ndị a rụpụtara anaghị arụ ọrụ ọgwụ.

T1 / 2 bụ ihe dịka awa iri na isii (awa iri na abụọ ruo iri abụọ). Ọ na - apịpụta ihe kachasị site na akụrụ n'ụdị metabolites, erughi 1% - na mmamịrị n'ụdị agbanweghị.

Usoro onunu ogwu na uzo icho ogwu a.

Emere ọgwụ a naanị maka ndị okenye (gụnyere ndị ọrịa afọ 65 gbagoro). Usoro akwadoro ịmalite bụ 30 mg.

Ekwesịrị ịhọrọ usoro ntụgharị dịka ogo nke glucose dị n'ọbara mgbe ịmalite ọgwụgwọ. Enwere ike ịmalite mgbanwe ọ bụla na-esote izu ma ọ dịkarịa ala oge izu abụọ.

Site na usoro nlekọta mmezi, otu ụbọchị kwa ụbọchị na-enye njikwa nke glucose ọbara dị mma. Theụ ọgwụ kwa ụbọchị nwere ike ịdị iche site na mg mg 30 (1 tab.) Ruo 90-120 mg (3-4 tab.). Ogo kachasị nke ụbọchị bụ 120 mg.

Ana a oụ ọgwụ ahụ ọnụ 1 oge / ụbọchị n'oge nri ụtụtụ.

Ọ bụrụ n’otu ọgwụ ị orụ otu ọgwụ ma ọ bụ karịa ga-efu gị, ịnweghị ike ị aụ ọgwụ dị elu na usoro ọzọ.

Maka ndị ọrịa na-anatabeghị ọgwụgwọ, ọgwụ izizi bụ 30 mg. Mgbe ahinyere dose ahụ n’otu n’otu rue mgbe ikewapụtara ọgwụgwọ ọgwụgwọ chọrọ.

Diabeton MV nwere ike dochie Diabeton na doses site na mbadamba 1 ruo 4 / ụbọchị.

Chinggbanwe site na ọgwụ hypoglycemic ọzọ na Diabeton MB anaghị achọ oge mgbanwe ọ bụla. First ga-ebu ụzọ kwụsị ị theụ ọgwụ hypoglycemic naanị wee kenye Diabeton MB.

Enwere ike iji Diabeton MB jikọta ya na biguanides, alpha-glucosidase inhibitors ma ọ bụ insulin.

Maka ndị ọrịa agadi, usoro ọgwụgwọ a na-atụ aro bụ otu ihe ahụ maka ndị ọrịa na-erubeghị afọ 65.

Ọ bụrụ na onye ọrịa ahụ natara ọgwụ na sulfonylurea dị iche iche nwere ogologo T1 / 2 (dịka ọmụmaatụ, chlorpropamide), mgbe ahụ, iji nlezianya nyochaa (njikwa glycemia) dị mkpa maka izu 1-2 iji zere mmepe nke hypoglycemia dị ka nsonaazụ nsonaazụ nsonaazụ nke usoro ọgwụgwọ gara aga.

N'ime ndị ọrịa nwere obere akụrụ gbasara obere ahaghị oke (CC site na 15 ruo 80 ml / min), a na-enye ọgwụ ahụ n'otu usoro ahụ ka ndị ọrịa nwere ọrụ mkpo nkịtị.

Mmetụta mmetụta Ọrịa mamịrị mv:

Site na usoro endocrine: hypoglycemia ga-ekwe omume.

Na akụkụ nke usoro nri: ọgbụgbọ, afọ ọsịsa ma ọ bụ afọ ntachi ga-ekwe omume (nke a na-ahụtaghị mgbe edepụtara ọgwụ ahụ n'oge nri), adịkarịghị - ụba ọrụ nke AST, ALT, alkaline phosphatase, n'ọnọdụ ụfọdụ - jaundice.

Site na sistemụ hemopoietic: adịkarịghị - anaemia, leukopenia, thrombocytopenia.

Mmeghachi omume nfụkasị: ọ na - adịkarịghị - itching, urticaria, furuwuru maculopapular.

Ihe mgbochi ọgwụ:

- ọrịa shuga mellitus ụdị 1 (insulin-dependance),

- mamịrị ketoacidosis, ọrịa mamịrị, ụkwara ume ọkụ,

Nsogbu akụrụ ma ọ bụ ọrịa ịba ọcha n'anya,

- nhazi nke miconazole,

- lactation (inye ara),

- ụmụaka na ndị ntorobịa erubeghị afọ 18,

- Hypersensitivity na gliclazide ma ọ bụ nke ọ bụla na ọgwụ ọgwụ, ọgwụ ndị ọzọ na-eme ka sulfonylurea, sulfonylamides.

A naghị atụ aro ka iji ọgwụ a jikọta ya na phenylbutazone ma ọ bụ danazole.

Jiri n'oge ime na lactation.

Enweghị data dị n'ụlọ ọgwụ ezughi oke iji chọpụta ihe egwu nwere ike ime na nsonaazụ fetotoxic n'ihi ojiji nke gliclazide n'oge ịtụrụ ime. Yabụ, iji Diabeton MV na ngalaba ndị ọrịa a ka contraindicated.

Mgbe ime mere mgbe ị na-a theụ ọgwụ ahụ, enweghị ezigbo ihe kpatara ọ ga-akwụsị ya. N'ụdị ndị a, yana n'ihe gbasara ịtụrụ ime, ekwesịrị ị kwụsị ọgwụ ahụ ma ekwesịrị iji ọgwụ insulin gaa n'ihu na nyocha nke ndị nyocha ụlọ nyocha niile nke carbohydrate metabolism. A na-atụ aro maka nlebara anya nke glucose ọbara.

Amabeghị ma grylazide dị na mmiri ara ara; ọ nweghị ihe akaebe na ọ nwere ike ịrịa hypoglycemia. N'akụkụ a, ọgwụgwọ gliclazide n'oge inye ara na-egbochi afọ ojuju.

Na nyocha anụmanụ, emere ka egosiputa na usoro sulfonylurea na usoro onunu elu nwere mmetụta teratogenic.

Ntuziaka pụrụ iche maka iji Diabeton mv.

Mgbe ị na-edepụta Diabeton MB, ekwesịrị iburu n'uche na hypoglycemia nwere ike ịmalite n'ihi ị sulfụ ọgwụ sulfonylurea, na n'ọnọdụ ụfọdụ n'ụdị siri ike ma dị ogologo, chọrọ ụlọ ọgwụ na nchịkwa glucose ọtụtụ ụbọchị.

Iji zere mmepe nke hypoglycemia, nlezianya ịhọrọ ndị ọrịa na nhọrọ nke usoro ọgwụgwọ, yana inye onye ọrịa ozi zuru ezu banyere usoro ọgwụgwọ a chọrọ.

Mgbe ị na-eji ọgwụ hypoglycemic mee ihe na ndị ọrịa agadi, ndị mmadụ na-adịghị enweta nri na-edozi ahụ nke zuru oke, na-arịa ọrịa izugbe, na ndị ọrịa nwere adrenal ma ọ bụ nkụda mmụọ, ohere nke ịmalite hypoglycemia na-aba ụba.

Ọrịa siri ike nke hypoglycemia siri ike ịmata na ndị agadi na ndị ọrịa na-anata ọgwụgwọ beta-blocker.

Mgbe ị na-edepụta ndị ọrịa ọrịa mamịrị Diabeton MV, ọ dị mkpa ilezi anya maka ọkwa glucose ọbara. Ekwesịrị ịmalite ọgwụgwọ nwayọọ nwayọọ na ụbọchị mbụ nke ọgwụgwọ ọ dị mkpa iji chịkwaa glucose na-ebu ọnụ yana mgbe ị risịrị nri.

Enwere ike ịnye Diabeton MB naanị ndị ọrịa na-anata nri mgbe niile, nke na-agụnye nri ụtụtụ ma na-enye ezigbo carbohydrates. Hypoglycemia na-etolitekarị nri nwere kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị alcoholụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge.

Mgbe ihe mgbaàmà nke cholestatic jaundice pụtara, a ga-akwụsị ịgwọ ya. Mgbe akwụsịrị Diabeton MB, mgbaàmà ndị a na-apụ n'anya.

N'ime ndị ọrịa nwere nnukwu ịba ọcha n'anya na / ma ọ bụ ọdịda akụrụngwa, mgbanwe mgbanwe ọgwụ na / ma ọ bụ ọgwụ ọgwụ nke gliclazide ga-ekwe omume. Karịsịa, nnukwu ịba ọcha n'anya ma ọ bụ akụrụ nwere ike ịmetụta nkesa nke gliclazide n'ime ahụ. Enweghị ike ịba ọcha n'anya nwekwara ike inye aka belata glucogenesis. Mmetụta ndị a na - ebute nsogbu nke ịmalite hypoglycemic ọnọdụ. Ọrịa hypoglycemia nke na-etolite na ndị ọrịa a nwere ike ịdị ogologo oge, n'ọnọdụ ndị dị otú a, ọgwụgwọ kwesịrị ekwesị ozugbo dị mkpa.

Nchịkwa nke ọkwa glucose ọbara n'ọbara n'ime ndị ọrịa na - anata ike hypoglycemic nwere ike ịkụda n'ọnọdụ ndị a: ahụ ọkụ, mmerụ ahụ, ọrịa na-efe efe ma ọ bụ usoro ịwa ahụ. N'ọnọdụ ndị dị otú ahụ, ọ nwere ike ịdị mkpa ịkwụsị iji usoro ọrịa mamịrị Diabeton MV ma depụta ọgwụ insulin.

Ofdị Ọrịa Diabeton MB (yana ọgwụ ọgwụ hypoglycemic ndị ọzọ) na ụfọdụ ndị ọrịa na-ebelata mgbe ogologo oge gachara. Nke a nwere ike ịbụ n'ihi mmụba nke ọrịa shuga mellitus ma ọ bụ mbelata ịzaghachi ọgwụ. A maara nke a dị ka nkwụghachi ọgwụ nke abụọ, nke a ga-adị iche na nke mbụ mgbe edepụtara ọgwụ ahụ na nke mbụ ma ọ naghị emepụta mmetụta a tụrụ anya ya. Tupu ichoputa onye ọrịa na ezughi oke nke ọgwụgwọ ọgwụ, ọ dị mkpa iji nyochaa izu oke nke nhọrọ dose na nnabata nnabata na usoro nri.

Na ndabere usoro ọgwụgwọ na Diabeton MB, a gaghị atụ aro phenylbutazone na danazole. Ọ ka mma iji NSAID ọzọ.

Megide usoro ọgwụgwọ na Diabeton MB, ọ dị mkpa ịhapụ ị ofụ mmanya ma ọ bụ ọgwụ, nke gụnyere ethanol.

Ọ dị mkpa ịgwa onye ọrịa ahụ na ndị ezinụlọ ya banyere ihe ize ndụ nke ịmalite ọrịa hypoglycemia, ihe mgbaàmà ya na ọnọdụ ndị metụtara mmepe ya. Ọ dịkwa mkpa ịkọwa ihe ọgwụ ọgwụ nje na nke abụọ bụ. A ga-agwa onye ọrịa banyere ihe ọghọm na uru ọgwụgwọ ọgwụgwọ chọrọ, ọ dịkwa mkpa ịgwa ya gbasara ụdị ọgwụgwọ ndị ọzọ. Ọrịa ahụ kwesịrị ịkọwapụta mkpa iri nri na-agbanwe agbanwe, mkpa maka mmega ahụ oge niile na ileba anya mgbe niile na-egosi ọbara na mmamịrị mmamịrị.

Nnyocha ụlọ nyocha

Ọ dị mkpa ịchọpụta ọkwa nke glucose na glycosylated haemoglobin n'ime ọbara, ọdịnaya glucose dị na mmamịrị.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Ndị ọrịa kwesịrị ịma ihe mgbaàmà hypoglycemia ma jiri nlezianya mee ihe mgbe ị na-anya ụgbọala ma ọ bụ na-arụ ọrụ chọrọ ọnụego mmetụta psychomotor dị elu.

Doụbiga ọgwụ ókè:

Mgbaàmà: hypoglycemia, n'ọnọdụ ndị siri ike - na-esonyere coma, nkwarụ na nsogbu akwara ndị ọzọ.

Ọgwụ: ana mgbazi mgbaàmà hypoglycemia site na ị carbohydụ carbohydrates, ịhọrọ otu ọgwụ na / ma ọ bụ ịgbanwe nri. A ga-aga n'ihu na-elezi ọnọdụ onye ọrịa anya ruo mgbe dọkịta na-aga ele anya doro anya na ahụike nke onye ọrịa ahụ anọghị n'ihe egwu. N'ọnọdụ dị oke mkpa, nlekọta ahụike mberede na ụlọ ọgwụ ozugbo dị mkpa.

Ọ bụrụ na enyo enyo na hypoglycemic coma na-enyo enyo ma ọ bụ na-achọpụta ọrịa, a na-awụnye onye ọrịa ngwa ngwa site na 50 ml nke ngwakọta nke dextrose (glucose) 40% iv. Mgbe ahụ, a na-edozi ngwakọta nke dextrose (glucose) ọzọ nke 5% na-agba ọbara n'ime ọbara iji nọgide na-enwe ọkwa glucose dị mkpa n'ọbara. Ekwesịrị iji nlezianya nyochaa nlezi anya n'oge awa 48. N'ọdịnihu, dabere n'ọnọdụ onye ọrịa ahụ, a ga-ekpebi ajụjụ banyere mkpa ọ dị inyochakwu ọrụ dị mkpa nke onye ọrịa.

N'ime ndị ọrịa nwere ọrịa imeju, enwere ike igbu oge plasma nke gliclazide. A naghị eme nchọpụta nke ọma maka ndị ọrịa dị otú a n'ihi nkwupụta nke gliclazide na protein plasma.

Mmekọrịta nke Diabeton MV na ọgwụ ndị ọzọ.

Ọgwụ na-eme ka mmetụta Diabeton MB dịkwuo mma

Ojiji nke Diabeton MB nwere miconazole (maka usoro) na-akwalite mmepe enwere ike ịba hypoglycemia rue Coma.

Agaghị atụ aro maka ịgwakọta ọnụ

Phenylbutazone (maka iji ya rụọ ọrụ) na-akwalite mmetụta hypoglycemic nke sulfonylureas, dị ka jiri protein ndị na-arụ plasma na-edochi agbụ ha na / ma ọ bụ mee ka ahụ ha dị ọcha na -eme ka ha kwụsịlata.

Iji otu oge nke Diabeton MB, ọgwụ ethanol na ethanol nwere ọgwụ na-abawanye hypoglycemia, na-egbochi mmeghachi omume nkwụghachi ụgwọ, ma nwee ike itinye aka na mmepe nke hypoglycemic coma.

Nkpachara anya pụrụ iche

Ojiji nke beta-igbochi egbochi ụfọdụ ọrịa hypoglycemia, dị ka palpitations na tachycardia. Imirikiti ndị na-egbochi beta ịhọrọ na-abawanye ugboro na ogo nke hypoglycemia.

Fluconazole na-abawanye ogologo oge nke T1 / 2 sulfonylureas ma nwekwuo ohere nke hypoglycemia.

Ojiji nke ACE inhibitors (captopril, enalapril) nwere ike imebi mmetụta hypoglycemic nke usoro sulfonylurea (dịka otu hypothesis si kwuo, a na-anabata nnabata glucose na ibelata insulin insulin). Hypoglycemic mmeghachi omume dị ụkọ.

Ọgwụ nke na-ebelata ike nke Diabeton MV

Agaghị atụ aro maka ịgwakọta ọnụ

N'iji ojiji nke oge a na danazol, mbelata ịdị irè nke Diabeton MB ga-ekwe omume.

Nkpachara anya pụrụ iche

Ihe jikọtara Diabeton MB yana chlorpromazine na ọnụọgụ dị elu (karịa 100 mg / ụbọchị) nwere ike ibute mmụba nke ọkwa glucose ọbara n'ihi mbelata insulin insulin.

Site na iji GCS n'otu oge (maka sistem, mpụga na mpaghara) na tetracosactides, ọkwa glucose ọbara na-abawanye site na mmepe ketoacidosis enwere ike (ibelata nnabata glucose n'okpuru mmetụta nke GCS).

Iji otu oge nke iji ọrịa shuga agakọ na progestogens, ekwesịrị ịbanye na mmetụta nke progestogens na usoro onyonyo dị elu.

Mgbe ejikọtara ọnụ, 2-adrenoreceptor na-akpali akpali (maka iji usoro) - ritodrin, salbutamol, terbutaline na-eme ka glucose ọbara dị elu (ekwesịrị ilebara ọkwa glucose ọbara anya, ọ bụrụ na ọ dị mkpa, ọ ga-adị mkpa ịnyefe onye ọrịa insulin).

Ọ bụrụ na ọ dị mkpa, ojiji nke njikọ ndị dị n'elu kwesịrị ịnye ọkwa nke glucose ọbara. Enwere ike inwe mkpa maka mgbatị usoro ọzọ maka Diabeton MB abụọ n'oge oge njikọta yana mgbe wepụchara ọgwụ ọzọ.

Mwepụta wepụtara ya na ihe mejupụtara

Sdị usoro onunu ogwu - mbadamba mbugharị gbanwetụrụ.

Nchikota kwa otu mbadamba 1:

• Ihe na-arụ ọrụ: Gliclazide - 60.0 mg.
• Ndị ọkachamara: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cP. 160.0 mg, magnesium stearate 1.6 mg, silikon dioxide colloidal anhydrous 5.04 mg.

Mlọ ọgwụ

Gliclazide bụ ọgwụ ana-akpọ sulfonylurea, ọgwụ a na-akpọ hypoglycemic nke dị iche na ọgwụ ndị yiri nke ahụ site na ọnụnọ N-nwere heterocyclic nke N-nwere nke njikọ endocyclic.

Glyclazide na-ebelata glucose ọbara site na-akpali mkpụrụ ndụ nke insulin site na mkpụrụ ndụ beta nke agwaetiti Langerhans. Mmụba na ọkwa nke insprandial insulin na C-peptide na-adịgide ka afọ afọ nke ọgwụgwọ gasịrị.

Na mgbakwunye na nsonaazụ metabolism metabolism, gliclazide nwere mmetụta hemovascular.

Mmetụta ọwụwa

Glyclazide na-ebelata ihe ize ndụ nke thrombosis nke obere arịa ọbara, na-emetụta usoro ndị nwere ike iduga mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na-akpata platelet (beta-thromboglobulin, thromboxane B2), yana mweghachi nke fibrinoly ndọtị anụ ahụ plasminogen na-arụ ọrụ.

Egwu

Mgbe nchịkwa ọnụ gasịrị, a na-etinye gliclazide kpamkpam. Ọbara nke gliclazide na plasma ọbara na-abawanye nwayọ n'oge awa isii mbụ, a na-ahụ ọkwa nke ala dị larịị awa isii ruo awa iri na abụọ.

Ngbanwe nke ndi mmadu di ala. Iri nri anaghị emetụta ọnụego ma ọ bụ etu esi enweta gliclazide.

Metabolism

Gliclazide bụ metabolized nke ukwu na imeju. Ọ dịghị metabolites nọ n'ọrụ na plasma.

Glyclazide bụ nke akụrụ ga - apịpụta n'ike: a na - ebupụ mkpụrụ ọgwụ dị ka ụdị metabolites, erughi 1% akụrụ na - agbanweghi. Nkera ọkara ndụ nke gliclazide dị ihe dị ka awa iri na abụọ ruo iri abụọ.

Ihe ngosi maka ojiji

Ọgwụ Diabeton MV 60 mg ka enyere ndị ọrịa karịrị afọ 18 maka ọgwụgwọ nke ọnọdụ ndị a:

• Diabetesdị ọrịa shuga 2dị nke abụọ na-enweghị ike nke usoro ọgwụgwọ nri, mmega ahụ na oke ibu.
• Mgbochi nsogbu nke ọrịa shuga mellitus: belata ihe ize ndụ nke microvascular (nephropathy, retinopathy) na nsogbu akwara (myocardial infarction, stroke) na ndị ọrịa nwere ụdị shuga mellitus 2 site na nchịkwa glycemic kpụ ọkụ n'ọnụ.

Usoro onunu ogwu na nhazi

Edere ọgwụ a naanị ndị okenye!

Ekwesịrị iji ọnụ a na-atụ aro ka ọ bụrụ nke a ga-ede ọnụ, otu oge kachasị n'oge nri ụtụtụ. Thebọchị kwa ụbọchị nwere ike ịbụ 30 -120 mg (1/2 -2 mbadamba) na otu ọgwụ. Ọ na-atụ aro ilo mbadamba ma ọ bụ ọkara nke mbadamba ihe na-enweghị ata ma ọ bụ nhichapịa.

Ọ bụrụ na ị youụ otu ọgwụ ma ọ bụ karịa nke ọgwụ ahụ, ị ​​nweghị ike ị aụ ọgwụ dị elu na usoro ọzọ, a ga-ewere ọgwụ ahụ echere n'echi ya.

Dị ka ọ dị na ọgwụ hypoglycemic ndị ọzọ, a ga-ahọrọ dose nke ọgwụ ahụ n'ọnọdụ ọ bụla dabere na ntinye nke glucose ọbara na HbAlc.

Usoro ọgwụgwọ mbụ

Usoro ọgwụgwọ akwadoro nke mbụ (gụnyere maka ndị agadi agadi 30 mg kwa ụbọchị (1/2 mbadamba)).

N'ọnọdụ nchịkwa zuru oke, enwere ike iji ọgwụ dị na ọgwụ a maka ọgwụgwọ mmezi. Site na njikwa glycemic ezughị ezu, ị canụ ọgwụ kwa ụbọchị nwere ike ịba ụba nke 60, 90 ma ọ bụ 120 mg.

Mmụba dị ukwuu ga-ekwe omume ọ bụghị tupu mgbe ọnwa ọgwụ ọ bụla gasịrị na ọgwụ aeburu na mbụ. Ewezuga ya bụ ndị ọrịa ihe nlebara mgbali ọbara agbadabeghị mgbe izu ụka abụọ gachara. N'ụdị ndị a, enwere ike ịbawanye dose ahụ izu abụọ mgbe mmalite nke nchịkwa.

Oke ọgwụ a tụrụ aro ya kwa ụbọchị bụ 120 mg.

Mbadamba mbadamba ọgwụ ọgwụ Diabeton® MV nke emere 60 mg ahaziri ihe dị ka mbadamba 2 nke Diabeton® MV mbadamba ụrọ nwere 30 mg agbanwe. Ọnụnọ nke notch na mbadamba 60 mg na-enye gị ohere kewaa mbadamba ma were kwa ụbọchị 30 mg (1/1 mbadamba 60 mg), na, ọ bụrụ na ọ dị mkpa, 90 mg (1 na 1/1/60 60 mg).

Na-agbanwe site na onye nnọchi anya hypoglycemic ọzọ na Diabeton MV 60 mg

Diabeton®: MV mbadamba nkume ndị nwere ihe ndọtị 60 mg agbanwere ka enwere ike iji ya kama iji ọgwụ hypoglycemic ọzọ maka nchịkwa ọnụ. Mgbe ị na-ebufe ndị ọrịa na-anata ọgwụ hypoglycemic ndị ọzọ maka nchịkwa ọnụ na Diabeton® MV, ha kwesịrị iburu uzo ha na ọkara ndụ ha. Dịka iwu, oge ntughari achoghi. Usoro izizi kwesịrị ịbụ mg mg 30 ma tinye ya titrated dabere na ịta glucose ọbara. Mgbe ejiri mkpụrụ ndụ sulfonylurea dochie Dioniaon® MV site na iji ogologo oge iji zere hypoglycemia nke ihe mmụba nke ndị na - arụ ọrụ hypoglycemic abụọ, ị nwere ike ịkwụsị ị themụ ha ọtụtụ ụbọchị.

Ọgwụ mbụ nke ọgwụ Diabeton® MV bụkwa 30 mg (1/2 mbadamba 60 mg) ma, ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba n'ọdịnihu, dị ka akọwara n'elu.

Ndị Ọrịa na Egwu Hypoglycemia

N'ime ndị ọrịa n'ihe ize ndụ nke ịmalite hypoglycemia (nri na-ezughi ezu ma ọ bụ nke na-adịghị edozi ahụ, nsogbu nke endocrine erughị ala: hypothyroidism, mwepụ nke glucocorticosteroids (GCS) mgbe ejiri ogologo oge na / ma ọ bụ nchịkwa na oke onunu ogwu, ọrịa siri ike nke akwara obi. sistemu - ọrịa obi na akwara siri ike, atherosclerosis siri ike nke akwara carotid, atherosclerosis nkịtị, a na-atụ aro ka iji obere opekata mpe (30 mg) nke ọgwụ Diabeton® MV.

Mgbochi ọrịa shuga

Iji nweta nchịkwa glycemic siri ike, ị nwere ike jiri nwayọ dịkwuo Diabeton® MV ruo 120 mg / ụbọchị, na mgbakwunye na nri na mmega ahụ, iji nweta ọkwa HbAlc nke chọrọ. Buru n'uche ihe ize ndụ nke ịmalite hypoglycemia. Na mgbakwunye, ọgwụ hypoglycemic ndị ọzọ, dịka ọmụmaatụ, metformin, inhibitor alpha-glucosidase inhibitor, ọgwụ hyazolidinedione ma ọ bụ insulin, nwere ike ịgbakwunye na ọgwụgwọ.

Ojiji nke ọgwụ n’oge afọ ime na lactation

Onweghi data obula banyere iji iko ndi kaadi oria Di Mọnk n’oge nke nwanyi ime. Agbanyeghị eziokwu ụmụ anụmanụ amabeghị na teratogenic na mmetụta ẹmbrayo nke nsị na nwa ebu n’afọ, ọgwụ a machiri ọgwụ maka ụmụ nwanyị dị ime. Ọ bụrụ n’ịchọpụta ọrịa shuga n’ime ụmụ nwanyị n’oge afọ ime, ahọpụtara onye ọrịa ahụ ọgwụgwọ ọzọ na-agaghị adị ize ndụ nye nwa ebu n’afọ. N'okwu a, dọkịta na-enyocha ọnọdụ nwanyị niile.

Ọ bụrụ na a gwọchara nwanyị Diabeton MV, na ime amaliteworị, ọgwụgwọ ahụ kwesịrị ịkwụsị ozugbo ma kpọtụrụ dọkịta, jide n'aka na ị ga-agwa maka ị takingụ ọgwụ.

Amachibidoro iji ọgwụ a hypoglycemic n'oge a na-enye nwa ara, ebe ọ bụ na ihe ndị dị n’ọrụ nke ọgwụ ahụ nwere ike ịbanye n’ime mmiri ara, wee banye n’ime ahụ nwa. Ọ bụrụ na ọ dị mkpa, a ga-akwụsị ị therapyụ ọgwụ.

Hypoglycemia

Dịka ọgwụ ọgwụ ndị ọzọ nke otu sulfonylurea, ọgwụ Diabeton MV nwere ike ime ka hypoglycemia bụrụ nke ịda ogbenye na oge ịkpa oke na enweghị nri. Ihe mgbaàmà puru iche nke hypoglycemia: isi ọwụwa, agụụ siri ike, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, mgbakasị ụra, mgbakasị ahụ, mgbanyụ belata, mmeghachi omume na-egbu oge, ịda mba, ọgba aghara, ọhụụ na okwu, aphasia, jijiji, paresis, ọnwụ nke njide onwe onye. , mmetụta nke enweghị enyemaka, nghọta zuru oke, nkụda mmụọ, adịghị ike, ihe ọdịdọ, bradycardia, delirium, iku ume, ura, ọdịda nke mmụọ na mmepe nke mmụọ, ruo ọnwụ.

A ga-ahụta mmeghachi omume Andrenergic: ịsụsọ nke ịba ụba, akpụkpọ "nnyapade", nchegbu, tachycardia, ọbara mgbali elu, palpitations, arrhythmia, na angina pectoris.

Dịka iwu, akara nke hypoglycemia na-akwụsị site na ị carbohydụ carbohydrates (sugar).

I sweetomi ihe ndi na ato uto adighi adighi nma. Na nzụlite nke usoro ndị ọzọ dị na sulfonylurea, a chọpụtara nlọghachi hypoglycemia mgbe enyemaka ya mechara nke ọma.

Na nnukwu hypoglycemia dị elu ma ọ bụ ogologo oge, a na-egosi nlekọta ahụike mberede, ikekwe enwere n'ụlọ ọgwụ, ọbụlagodi na enwere mmetụta na ị carbohydụ carbohydrates.

Nsonaazụ ndị ọzọ

• Site na eriri afọ: mgbu afọ, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, afọ ntachi. Drugakingụ ọgwụ n’oge nri ụtụtụ na-egbochi mgbaama ndị a ma ọ bụ belata ha.
• N’akụkụ anụ ahụ na akpụkpọ anụ ahụ: ihe ọkụ ọkụ. itching urticaria, edere Quincke, erythema, maculopapullous ihe ọkụ ọkụ, mmeghachi omume jọgburu onwe (dịka ọrịa Stevens-Jones na-egbu egbu na necrolysis na-egbu egbu).
• Ahụhụ Hematopoietic na sistemụ lymphatic: nsogbu ọgbụgba ọbara (anaemia, leukopenia, thrombocytopenia, granulocytopenia) dị ụkọ.
• N'akuku nke imeju na akwara biliary: mmụba nke enzymes "imeju" (aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase), ịba ọcha n'anya (ikpe dịpụrụ adịpụ). Ọ bụrụ na ọrịa jalestice mere, ekwesịrị ịkwụsị ịgwọ ọrịa ahụ.
• Site n'akụkụ akụkụ ahụ nke ọhụụ: ọgba aghara a na-ahụ anya n'oge nwere ike ime n'ihi mgbanwe mgbanwe nke glucose ọbara, ọkachasị na mmalite ọgwụgwọ.

Mmekọrịta na ọgwụ ndị ọzọ

Ekwesighi ị takenụ ọgwụ Diabeton MV 60 mg n'otu oge na miconazole, ebe ọ bụ na mkparịta ụka a na-akpata mmụba na hypoglycemic mmetụta, nke nwere ike iduga mmepe nke hypoglycemic coma.

Ọgwụ a nwere ike belata nsonaazụ ọgwụgwọ mgbochi ọgwụ si n'ọnụ, yabụ, ndị ọrịa na-eji usoro nchekwa a ga-adọ aka na ntị gbasara ihe egwu nke ịtụrụ ime na-achọghị.

A naghị atụ aro ka ọgwụ ahụ jikọta ya na ọgwụ ndị na-agụnye ethanol, n'ihi na nke a nwere ike iduga mmụba na hypoglycemic mmetụta na mmepe nke nsogbu imeju siri ike.

Usoro ahịa ọgwụ ahịa

Ọgwụ ndị a bụ analogues nke ọgwụ Diabeton MV:

• Mbadamba akwụkwọ ndụ glidiab
• Glidiab MV,
• Diabefarm MV,
• Gliclazide MV.

Tupu iji iji ọgwụ analog dochie ọgwụ edepụtara, onye ọrịa ahụ kwesịrị ịgakwuru onye ọrịa endocrinologist.

Ọnụ ego ọgwụ Diabeton MV 60 mg na ọgwụ ọgwụ Moscow bụ 150-180 rubles kwa mkpọ (mbadamba 30).

Usoro onunu ogwu:

Ngwakọta:
Otu mbadamba ihe nwere:
Arụ Ọrụ: gliclazide - 60.0 mg.
Ndị e mere: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cp 160.0 mg, magnesium stearate 1.6 mg, anhydrous colloidal silicon dioxide 5.04 mg.

Nkọwa
White, biconvex, mbadamba osisi oval nke nwere ogbonye ma dochie "DIA" "60" n'akụkụ abụọ.

Otu na-ere ọgwụ:

Koodu ATX: A10BB09

NKWUKWU PHARMACOLOGIC

Mlọ ọgwụ
Glyclazide bụ ọgwụ a na-akpọ sulfonylurea, ọgwụ a na-akpọ hypoglycemic nke dị iche na ọgwụ ndị yiri ya site na ọnụnọ nke heterocyclic nke N-nwere nwere njikọ njikọ endocyclic.
Gliclazide na -ebelata mkpụkọ nke glucose ọbara, na-akpali nzuzo nke β-sel nke agwaetiti nke Langerhans. Mmụba na mkpokọta nke insprandial insulin na C-peptide na-adịgide ka afọ afọ nke ọgwụgwọ gasịrị.
Na mgbakwunye na nsonaazụ metabolism metabolism, gliclazide nwere mmetụta hemovascular.

Mmetụta insulin insulin
Na ụdị ọrịa mellitus nke 2, ọgwụ a na-eweghachi mmalite nke insulin na-emeghachi omume na nzaghachi glucose ma na-eme ka akụkụ nke abụọ nke insulin ahụ dịkwuo elu. A na-achọpụta mmụba dị elu na mmiri insulin na nzaghachi mkpali n'ihi nri nri ma ọ bụ nchịkwa glucose.

Mmetụta ọwụwa
Glyclazide na-ebelata ihe ize ndụ nke thrombosis nke obere arịa ọbara site na-emetụta usoro ndị nwere ike iduga mmepe nke nsogbu na ọrịa shuga mellitus: ịhapụ akụkụ nke platelet na nrapado na mbelata ihe ndị na-eme ka platelet na-arụ ọrụ (beta-thromboglobulin, thromboxane B₂), yana iweghachi ọrụ fibrinolytic nke vaskụla endothelium ma mee ka ọrụ plasminogen anụ ahụ dịkwuo elu.
Njikwa glycemic siri ike dabere na iji Diabeton ® MV (HbA1c) atụmatụ nchịkwa glycemic siri ike gụnyere nhọpụta ọgwụ Diabeton ® MV na ịbawanye ọgwụ ya megide ndabere nke (ma ọ bụ kama) usoro ọgwụgwọ tupu ịgbakwunye ya ọgwụ hypoglycemic ọzọ (dịka ọmụmaatụ, metformin, alfa-glucosidase inhibitor Thiazolidinedione derivative ma ọ bụ insulin.) Nkezi ọgwụ kwa ụbọchị Diabeton ® MV n’ebe ndị ọrịa nọ n’otu nchịkwa kpụ ọkụ n’ọnụ bụ 103 mg, nke kachasị elu kwa ụbọchị. ọgwụ a bụ 120 mg.
Megide ndabere nke iji ọgwụ ọgwụ Diabeton ® MV nọ n'ime nchịkwa glycemic kpụ ọkụ n'ọnụ (oge na-esochi oge 4.8 afọ, nkezi HbA1c larịị 6.5%) ma e jiri ya tụnyere otu njikwa akara (nkezi HbA1c larịị 7.3%), a na-egosi mbelata dị ukwuu nke 10% nsogbu dị na ya nke ugboro abụọ jikọrọ nnukwu macro na nje
E mepụtara uru ahụ site na ibelata ọghọm ikwu dị ukwuu: nsogbu ndị dị na microvascular site na 14%, mmalite nke ọganihu nke nephropathy site na 21%, ihe na-eme microalbuminuria site na 9%, macroalbuminuria site na 30% na mmepe nke nsogbu akwara site 11%.
Abamuru nke njikwa glycemic siri ike mgbe ị na-a Diụ ọrịa mamịrị ® MV adabereghị na uru ndị a na-enweta na usoro ọgwụgwọ antihypertensive.

Mlọ ọgwụ

Egwu
Mgbe nchịkwa ọnụ gasịrị, a na-etinye gliclazide kpamkpam. Ọbara nke gliclazide na plasma ọbara na-abawanye nwayọ n'oge awa isii mbụ, a na-ahụ ọkwa nke ala dị larịị awa isii ruo awa iri na abụọ. Ngbanwe nke ndi mmadu di ala.
Iri nri anaghị emetụta ọnụego ma ọ bụ etu esi enweta gliclazide.

Nkesa
Ihe dị ka 95% nke glycazide na-ejikọ protein protein. Olu nke nkesa dị ihe dịka 30 lita.Thenweta ọgwụ mamịrị abet MV na 60 mg mgbe ọ bụla kwa ụbọchị na-eme ka enwee ike ị nweta gliclazide na plasma ọbara dị mma karịa awa 24.

Metabolism
Gliclazide bụ metabolized nke ukwu na imeju. Ọ dịghị metabolites nọ n'ọrụ na plasma.

Ojiji
Glyclazide bụ nke akụrụ ga - abụrịrị: a na - ebupụta ntụpọ n'ụdị metabolites, ihe na - erughị 1% akụrụ na - agbanweghi. Ọkara ọkara nke gliclazide bụ nkezi nke awa 12 ruo 20.

Linearity
Mmekọrịta dị n'etiti ọgwụ a (ụrụ (ihe ruru 120 mg) na mpaghara dị n'okpuru ọgwụ pharmacokinetic “ịta - oge” bụ ahịrị.

Onu ogugu ndi puru iche
Ndị okenye
N'ime ndị agadi, enweghị mgbanwe dị ukwuu na pọọmọnokinetic ọgwụ.

EGO NA-EGO

• Diabetesdị ọrịa shuga 2dị nke abụọ na-enweghị ike nke usoro ọgwụgwọ nri, mmega ahụ na oke ibu.
• Mgbochi nsogbu nke ọrịa shuga mellitus: belata ihe ize ndụ nke microvascular (nephropathy, retinopathy) na nsogbu akwara (myocardial infarction, stroke) na ndị ọrịa nwere ụdị shuga mellitus 2 site na nchịkwa glycemic kpụ ọkụ n'ọnụ.

• hypersensitivity na gliclazide, ihe ndị ọzọ na-eme ka sulfonylurea, sulfonamides ma ọ bụ ndị na-esonye na ọgwụ ahụ,
• ụdị shuga 1
• ọrịa mamịrị ketoacidosis, precca mamịrị, mamịrị shuga,
• oke akụrụ gbasara akwara ma ọ bụ enweghị nsogbu (n'ọnọdụ ndị a, a na-atụ aro ka ya jiri insulin),
• na-ewere miconazole (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ”),
• afọ ime na lactation (lee mpaghara “Oge ime na lactation”),
• afọ ruo afọ 18.

N'ihi eziokwu na nkwadebe ahụ nwere lactose, a naghị akwado Diabeton MV maka ndị ọrịa nwere ọrịa ekweghị hazie lactose, galactosemia, glucose-galactose malabsorption.
A naghị akwado ka ejiri ya na phenylbutazone ma ọ bụ danazole (lee mpaghara "Mmekọrịta na ọgwụ ndị ọzọ").

Jiri nlezianya
Okenye, enweghi nsogbu na / ma obu ihe oriri adighi edozi, ike nri glucose-6-phosphate dehydrogenase, ọrịa siri ike nke akwara obi, hypothyroidism, adrenal or pituitary insulence, gbasara akụrụ na / ma ọ bụ imeju, ogologo oge na glucocorticosteroids (GCS), ahoụrụma.

NKWUKWU EGO NA-EKWU NIILE

Ime
Enweghị ahụmịhe na gliclazide n'oge afọ ime. Ihe omuma banyere ojiji nke ihe ndi ozo nke sulfonylurea n’oge di ime.
N'ime ihe omumu banyere umu anumanu, achoputala ihe omuma di nke gliclazide.
Iji belata ihe egwu nke ọrịa metụtara ọrịa metụtara ọrịa, ọ dị mkpa ijikwa ezigbo (ọgwụgwọ kwesịrị ekwesị) nke ọrịa shuga mellitus. Anaghị eji ọgwụ hypoglycemic ọgwụ n'oge ime.
Insulin bu ogwu eji eme nhọrọ maka ogwu oria shuga n’ime ndi nwanyi di ime.
A na-atụ aro ka iji ọgwụ inspoglycemic nke na-aralụ ọgwụ jiri ọgwụ insulin dochie ya ma n'oge ime atụgharịrị, ma ọ bụrụ na ime mere mgbe ị na-a theụ ọgwụ ahụ.

Lactation
N'iburu n'uche enweghị data na ị gụ gliclazide na mmiri ara ara yana ihe ọghọm nke ịmalite hypoglycemia nke afọ, a na-enye ụmụ ara ara n'oge ọgwụ.

OSM ANDAKA NA ỌM .AKA

Ọgwụ a bụ naanị iji ọgwụ nnweta.

Ekwesịrị iji ọgwụ ndị a tụrụ aro ka a oara ọnụ, 1 oge kwa ụbọchị, ọkacha mma n'oge nri ụtụtụ.
Dosebọchị kwa ụbọchị nwere ike ịbụ 30-120 mg (1 /₂ -2 mbadamba) n’otu udiri.
Ọ na-atụ aro ilo mbadamba ma ọ bụ ọkara nke mbadamba ihe na-enweghị ata ma ọ bụ nhichapịa.
Ọ bụrụ na ị youụ otu ọgwụ ma ọ bụ karịa nke ọgwụ ahụ, ị ​​nweghị ike ị aụ ọgwụ dị elu na usoro ọzọ, a ga-ewere ọgwụ ahụ echere n'echi ya.
Dị ka ọ dị na ọgwụ hypoglycemic ndị ọzọ, a ga-ahọrọ dose nke ọgwụ ahụ n'ọnọdụ nke ọ bụla, dabere na ntinye nke glucose ọbara na HbA1c.

Imu nke mbu
Ọgwụ akwadoro nke mbụ (gụnyere maka ndị ọrịa agadi, ≥ 65 afọ) bụ mg mg 30 kwa ụbọchị (1 /₂ ọgwụ).
N'ọnọdụ nchịkwa zuru oke, enwere ike iji ọgwụ dị na ọgwụ a maka ọgwụgwọ mmezi. Site na njikwa glycemic ezughị ezu, ị canụ ọgwụ kwa ụbọchị nwere ike ịba ụba nke 60, 90 ma ọ bụ 120 mg.
Mmụba dị ukwuu ga-ekwe omume ọ bụghị tupu mgbe ọnwa ọgwụ ọ bụla gasịrị na ọgwụ aeburu na mbụ. Ewezuga ya bụ ndị ọrịa ihe nlebara mgbali ọbara agbadabeghị mgbe izu ụka abụọ gachara. N'ụdị ndị a, enwere ike ịbawanye dose ahụ izu abụọ mgbe mmalite nke nchịkwa.
Oke ọgwụ a tụrụ aro ya kwa ụbọchị bụ 120 mg.
Mbadamba mbadamba ọgwụ ọgwụ Dika ® MV mbadamba MV nke nwere 60 mg nke ọ bụla nwere ihe ọ dị ka mbadamba 2 nke Diabeton ® MV mbadamba ụrọ nke 30 mg agbanwe. Ọnụnọ nke notch na mbadamba 60 mg na-enye gị ohere kewaa mbadamba ma were kwa ụbọchị 30 mg (1 /₂ mbadamba 60 mg), ma ọ bụrụ na ọ dị mkpa 90 mg (1 na 1 /₂ Mbadamba 60 mg).

Ntughari site na ị Diụ ọgwụ mamịrị abet mbadamba ọgwụ 80 mg na ọgwụ mamịrị tablets MV mbadamba nkume ndị eji mmegharị 60 mg gbanwee. A ga-eji dochie mbadamba ọgwụ ọgwụ 1 abet 80 mg ọgwụ ọgwụ 1 /₂ Mbadamba ụrọ nwere ihe ndebiri agbaziri Diabeton ® MV 60 mg. Mgbe ị na-ebufe ndị ọrịa site na Diabeton ® 80 mg na Diabeton ® MV, a na-atụ aro njikwa glycemic.

Na-agbanwe site na ị takingụ ọgwụ hypoglycemic ọzọ na ọgwụ Diabeton ® MV mbubata nke 60 mg gbanwechara.
A ga-eji ọgwụ Diabeton ® MV ọgwụ nke nwere ndọtị 60 mg agbanwe karịa nke ọgwụ hypoglycemic ọzọ maka nchịkwa ọnụ. Mgbe ị na-ebufe ndị ọrịa na-anata ọgwụ hypoglycemic ndị ọzọ maka nchịkwa ọnụ na Diabeton ® MV, ha kwesịrị ibute ọgwụ ha na ọkara ndụ. Dịka iwu, oge ntughari achoghi. Usoro izizi kwesịrị ịbụ mg mg 30 ma tinye ya titrated dabere na ịta glucose ọbara.
Mgbe ejiri ogologo nke ndụ ọkara iji dochie Diabeton ® MV iji zere hypoglycemia site na mmụba nke ndị na - arụ ọrụ hypoglycemic abụọ, ị nwere ike ịkwụsị ị themụ ha ruo ọtụtụ ụbọchị. Usoro mbu nke ọgwụ Diabeton ® MV bụkwa 30 mg (1 /₂ mbadamba 60 mg) na, ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba n’ọdịnihu, dịka akọwara n’elu.

Ejikọtara iji ọgwụ hypoglycemic ọzọ
Enwere ike iji Diabeton ® MV jikọta ya na biguanidins, alfa-glucosidase inhibitors ma ọ bụ insulin. Site na nchịkwa nchịkwa na-ezughị ezu, a ga-eji ọgwụ nlezianya depụta ọgwụ insulin ọzọ.

Ndị okenye na-arịa ọrịa
Ọchọghị ịmegharị ọgwụgwọ maka ndị ọrịa karịrị afọ 65.

Ọrịa enweghị akụrụ
Nsonaazụ nke ọmụmụ ụlọ ọgwụ gosipụtara na ọ dịghị achọrọ ndozi nke ndị ọrịa nwere nsogbu ọdịda na obere afọ na-adịghị ala ala. A na-atụ aro imechi ọgwụ anya.

Ndị Ọrịa na Egwu Hypoglycemia
N'ime ndị ọrịa nọ n'ihe ize ndụ nke ịmalite hypoglycemia (nri na-ezughị ezu ma ọ bụ nke na-adịghị edozi ahụ, nsogbu nke endocrine erughị ala ma ọ bụ nke na-adịghị mma - pituitary na adrenal insufficiency, hypothyroidism, kagbuo glucocorticosteroids (GCS) mgbe ejiri ogologo oge na / ma ọ bụ nchịkwa na nnukwu usoro onunu ogwu, ọrịa obi na-arịa nnukwu ọrịa. sistem vaskụla - ọrịa obi na-arịa oke akwara, atherosclerosis siri ike nke akwara carotid, atherosclerosis nkịtị), a na-atụ aro ka iji obere opekata mpe (30 mg) nke akwadebe ATA Diabeton ® MV.

Mgbochi ọrịa shuga
Iji mezuo nchịkwa glycemic siri ike, ị nwere ike jiri nwayọ dịkwuo elu nke ọgwụ Diabeton ® MV ruo 120 mg / ụbọchị na mgbakwunye na nri na mmega ahụ iji nweta ogo HbA1c. Buru n'uche ihe ize ndụ nke ịmalite hypoglycemia. Na mgbakwunye, ọgwụ hypoglycemic ndị ọzọ, dịka ọmụmaatụ, metformin, inhibitor alpha-glucosidase inhibitor, ọgwụ thiazolidinedione ma ọ bụ insulin, nwere ike ịgbakwunye na ọgwụgwọ.

Childrenmụaka na ụmụaka nọ n’agbata afọ 18.
Achọpụtaghị data banyere arụmọrụ yana nchekwa nke ọgwụ na ụmụaka yana ndị na-eto eto na-erubeghị afọ 18.

NWAANYI EGO
Nyere ahụmịhe nke gliclazide, ị kwesịrị icheta banyere ohere nke ịmalite nsonaazụ ndị a.

Hypoglycemia
Dịka ọgwụ ọjọọ ndị ọzọ nke otu sulfonylurea, ọgwụ Diabeton ® MV nwere ike bute hypoglycemia bụrụ nke na-eri nri oge adịghị adị yana ọkachasị ma ọ bụrụ na echefula iri nri. Ihe mgbaàmà puru iche nke hypoglycemia: isi ọwụwa, agụụ siri ike, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, mgbakasị ụra, mgbakasị ahụ, mgbanyụ belata, mmeghachi omume na-egbu oge, ịda mba, ọgba aghara, ọhụụ na okwu, aphasia, jijiji, paresis, ọnwụ nke njide onwe onye. , mmetụta nke enweghị enyemaka, nghọta zuru oke, nkụda mmụọ, adịghị ike, ihe ọdịdọ, bradycardia, delirium, iku ume, ura, ọdịda nke mmụọ na mmepe nke mmụọ, ruo ọnwụ.
A ga-ahụta mmeghachi omume Andrenergic: ịsụsọ nke ịba ụba, akpụkpọ "nnyapade", nchegbu, tachycardia, ọbara mgbali elu, palpitations, arrhythmia, na angina pectoris.

Dịka iwu, akara nke hypoglycemia na-akwụsị site na ị carbohydụ carbohydrates (sugar). I sweetomi ihe ndi na ato uto adighi adighi nma. Na nzụlite nke usoro ndị ọzọ dị na sulfonylurea, a chọpụtara nlọghachi hypoglycemia mgbe enyemaka ya mechara nke ọma.

Na nnukwu hypoglycemia dị elu ma ọ bụ ogologo oge, a na-egosi nlekọta ahụike mberede, ikekwe enwere n'ụlọ ọgwụ, ọbụlagodi na enwere mmetụta na ị carbohydụ carbohydrates.

Nsonaazụ ndị ọzọ

Site na eriri afọ: mgbu afọ, ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, afọ ntachi. Drugakingụ ọgwụ n’oge nri ụtụtụ na-egbochi mgbaama ndị a ma ọ bụ belata ha.

Nsonaazụ ndị a abụghị ihe a na-ahụkarị:

Na akpụkpọ anụ ahụ ọnya, itching, urticaria, Quincke edema, erythema, maculopapular fash, mmeghachi omume jọgburu onwe (dị ka Stevens-Jones syndrome na tocrolysis na-egbu egbu).

Site na akụkụ ahụ haemopoietic na lymphatic sistemụ: Ọrịa hematological (anaemia, leukopenia, thrombocytopenia, granulocytopenia) dị ụkọ. Dịka iwu, ihe ịtụnanya ndị a ga - atụgharị ma ọ bụrụ na a kwụsịrị ọgwụgwọ.

N'akuku nke imeju na akwara biliary: mmụba nke enzymes “imeju” (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), ịba ọcha n'anya (ikpe dịpụrụ adịpụ). Ọ bụrụ na ọrịa jalestice mere, ekwesịrị ịkwụsị ịgwọ ọrịa ahụ.

Ihe omume ndị a na - agbanwe agbanwe ma ọ bụrụ na a kwụsịrị ọgwụgwọ.

Site n'akụkụ akụkụ ahụ nke ọhụụ: nhụsianya na-ahụ anya n'oge nwere ike ime n'ihi mgbanwe nke mgbanye glucose ọbara, ọkachasị na mmalite ọgwụgwọ.

Nsonaazụ ndị ọzọ sitere na usoro nke sulfonylurea: dịka ọ dị n'ụkpụrụ ndị ọzọ nke sulfonylurea, ihe ndị a na-esote ya kwuru bụ nke a: erythrocytopenia, agranulocytosis, hemolytic anaemia, pancytopenia, vasculitis allergies, hyponatremia Enwere mmụba na ọrụ nke enzymes “imeju”, ọrụ imeju na-arụ ọrụ (dịka ọmụmaatụ, na mmepe nke cholestasis na jaundice) na ịba ọcha n'anya, ngosipụta belatara ka oge na-aga ịkwụsị akwụkwọ nkwuputa sulfonylurea, mana n'ọnọdụ ụfọdụ butere imeju na-eyi ndụ egwu.

Nsonaazụ ndị a chọpụtara na ule nke ụlọ ọgwụ
N'ime ọmụmụ ihe ADVANCE, enwere obere ọdịiche na oge ihe ọghọm dị iche iche dị n'etiti ndị ọrịa abụọ ahụ. Onweghi nchekwa data nchekwa ọhụụ a natara. Ọnụ ọgụgụ dị nta nke ndị ọrịa nwere hypoglycemia siri ike, mana mkpokọta hypoglycemia dị ala. Ọnọdụ nke hypoglycemia n'ime nnukwu nchịkwa glycemic dị elu karịa nke otu njikwa glycemic ọkọlọtọ. Ọtụtụ akụkụ nke hypoglycemia n'ime usoro nchịkwa glycemic ka a hụrụ megide mmalite nke usoro insulin na-eweta ọgwụ.

OGBONA
N'ihe banyere njigide nke usoro sulfonylurea, hypoglycemia nwere ike ịmalite.
Ọ bụrụ na ị na-enweta mgbaàmà dị nro nke hypoglycemia na-enweghị mmetụ mmụọ ma ọ bụ ihe mgbaàmà akwara, ị ga-eme ka nri ndị carbohydrates dịkwuo na nri, belata dose nke ọgwụ na / ma ọ bụ gbanwee nri. Ikwusi nso banyere nlekọta ahụike banyere ọnọdụ onye ọrịa ahụ kwesịrị ịga n'ihu ruo mgbe enwere obi ike na ọ nweghị ihe na-etinye ahụ ike ya. Ikekwe mmepe nke ọnọdụ hypoglycemic siri ike, tinyere coma, nkwarụ ma ọ bụ nsogbu akwara ndị ọzọ. Ọ bụrụ na ụdị mgbaàmà ndị ahụ apụta, nlekọta ahụike mberede na ụlọ ọgwụ ozugbo ọ dị mkpa.
N'ọnọdụ akpọnwụ hypoglycemic ma ọ bụ ọ bụrụ na enyo ya enyo, a na-ara onye ọrịa ọgwụ na 50 ml nke ihe 20-30% nke dextrose (glucose). Mgbe ahụ, a na-edozi ihe ndozi 10% dextrose iji jiri aka gị wee nwee ike itinye glucose ọbara ọbara karịa 1 g / L. Ekwesịrị iji nlezianya nyochaa ọkwa glucose ọbara na nyochaa onye ọrịa ahụ ma ọ dịkarịa ala awa 48 na-esote. Mgbe oge a gasị, dabere n'ọnọdụ onye ọrịa, dibịa na-aga na-ekpebi mkpa ọ dị inyochakwu ya. Nchọpụta adịghị arụ ọrụ n'ihi nkwupụta akpọrọ nke gliclazide na protein protein.

NWAANYI NA EGO

1) Ọgwụ na ihe ndị na-abawanye ohere ịba ụba hypoglycemia:
(na - emeziwanye mmetụta nke gliclazide)

Ngwakọta ndị amachibidoro
- Miconazole (na njikwa sistemụ na mgbe ị na-eji gel na onco mural): na-eme ka mmetụta hypoglycemic nke gliclazide (hypoglycemia nwere ike ịmalite ruo na coma).

Ngwakọta agwaghị ya
- Phenylbutazone (nchịkwa usoro): na - eme ka mmetụta hypoglycemic nke ihe nchịkwa sulfonylurea (kwụsị ha na nkwukọrịta na protein plasma na / ma ọ bụ mee ka mkpochapu ahụ ghara ịdị).
Ọ ka mma ka ị useụ ọgwụ mgbochi mbu ọzọ. Ọ bụrụ na ọ dị mkpa phenylbutazone, a ga-adọ onye ọrịa aka na ntị banyere mkpa ọ dị ịchịkwa glycemic. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịhazigharị ọgwụ ọgwụ Diabeton ® MV ka ị na-ewere phenylbutazone na mgbe ọ gachara.
- Ethanol : na - akwalite hypoglycemia, na-egbochi mmeghachi omume nkwụghachi ụgwọ, nwere ike itinye aka na mmepe nke hypoglycemic coma. Ọ dị mkpa ịjụ ị medicinesụ ọgwụ, nke gụnyere ethanol na ị alcoholụ mmanya.

Cakpachara anya
Glyclazide na ọgwụ ụfọdụ: hypoglycemic ndị ọzọ (insulin, acarbose, metformin, thiazolidinidiones, dipeptidyl peptidase-4 inhibitors, GLP-1 agonist), ndị na-egbochi beta-adrenergic na-egbochi, fluconazole, angiotensin-antiplatelet inhibitors, caprimin,₂Ndị na-anabata yahistamine, ndị na-egbochi monoamine oxidase, sulfonamides, clarithromycin na ọgwụ mgbochi na-abụghị steroid) na-abawanye na mmụba hypoglycemic na ihe ize ndụ nke hypoglycemia.

2) Ọgwụ na-abawanye glucose ọbara:
(mmetụta adịghị ike nke gliclazide)

- Danazole: nwere mmetụta ọrịa mamịrị. Ọ bụrụ na ị thisụ ọgwụ a dị mkpa, a na-adụ onye ọrịa ọdụ ka ọ jiri nlezianya nyochaa glucose ọbara. Ọ bụrụ na ọ dị mkpa, nchịkwa nkwonkwo ọgwụ, a na-atụ aro ka ịhọrọ ọgwụ hypoglycemic ma ọ bụrụ n'oge nlekọta nke danazol na mgbe ọpụpụ ya.

Cakpachara anya
- Chlorpromazine (antipsychotic) : na nnukwu doses (ihe karịrị 100 mg kwa ụbọchị) na-eme ka nchịkọta glucose dị n'ọbara, na -ebelata secretion nke insulin.
A na-atụ aro iji njikwa glycemic mee ihe. Ọ bụrụ na ọ dị mkpa, nchịkwa nkwonkwo ọgwụ, a na-atụ aro ka ịhọrọ ọgwụ hypoglycemic, ma n'oge nlekọta nke ọgwụ mgbochi na mgbe mwepụ ya.
- GKS (usoro na ngwa mpaghara: intraarticular, anụ ahụ, nchịkwa rectal) na tetracosactide: mee ka ịbawanye ụba nke glucose ọbara na mmepe nke ketoacidosis (belata na ntachi obi na carbohydrates). A na-atụ aro iji nchịkwa glycemic mee ihe, karịsịa mmalite nke ọgwụgwọ. Ọ bụrụ na ọ dị mkpa ijikọ ọgwụ ọnụ, enwere ike ịhazigharị ọgwụ hypoglycemic ma oge nchịkwa GCS yana mgbe ha wepụtasịrị ya.
- Ritodrin, salbutamol, terbutaline (nchịkwa intravenous): beta-2 adrenergic agonists na-eme ka ịbawanye ụba glucose ọbara.
Ekwesịrị ị attentiona ntị na mkpa nke njide onwe onye. Ọ bụrụ na ọ dị mkpa, a na-atụ aro inyefe onye ọrịa ahụ ọgwụ insulin.

3) Nchikota kwesiri itinye n’ime ya

- Anticoagulants (wdg. warfarin)
Nchịkọta nke sulfonylureas nwere ike ịkwalite nsonaazụ anticoagulants mgbe ejikọtara ọnụ. Enwere ike ịchọ ndozi ọgwụ Anticoagulant.

AKWSTRUCTIONKWỌ NDEC NA-EGO

Hypoglycemia
Mgbe ị na-a sulfụ ọgwụ sulfonylurea, gụnyere gliclazide, hypoglycemia nwere ike ịmalite, n'ọnọdụ ụfọdụ n'ụdị siri ike ma na-adịte aka, chọrọ ụlọ ọgwụ na nchịkwa ọgbụgba nke usoro dextrose ruo ọtụtụ ụbọchị (lee akụkụ “Side Side”).
Enwere ike ịnye ọgwụ ahụ naanị maka ndị ọrịa ahụ nri ha bụ oge niile ma tinye nri ụtụtụ. Ọ dị ezigbo mkpa iji nri were nweta nri zuru oke, ebe ọ bụ na ihe ize ndụ nke ịmalite hypoglycemia na-abawanye site na nri na-ezighi ezi ma ọ bụ na-ezughị ezu, yana mgbe ị na-eri nri na-adịghị mma na carbohydrates.
Hypoglycemia na-etolitekarị obere nri kalori, mgbe ọ gbasịrị ogologo ma ọ bụ mgbatị ahụ siri ike, mgbe ị drinkingụ mmanya na-egbu egbu, ma ọ bụ mgbe ị na-ewere ọtụtụ ọgwụ hypoglycemic n'otu oge.
A, mgbaàmà hypoglycemia na-apụ n'anya mgbe ị risịrị nri nwere carbohydrates (dịka shuga). Okwesiri iburu n’uche na iwere ihe uto n’enweghi aka iwepu ihe mgbaàmà hypoglycemic. Ahụmahụ nke iji usoro ndị ọzọ na-enye usoro sulfonylurea na-atụ aro na hypoglycemia nwere ike ịmaliteghachi n'agbanyeghị ngbanwe mbụ dị irè nke ọnọdụ a. N'ọnọdụ nke akpọrọ hypoglycemic ọrịa ma ọ bụ mee ka ọ dị ogologo oge, ọbụlagodi n'ọnọdụ ndozi nwa oge mgbe ị risịrị nri nwere carbohydrates, nlekọta ahụike mberede dị mkpa, ruo ụlọ ọgwụ.
Iji zere mmepe nke hypoglycemia, mmadụ ị individualụ ọgwụ ọ andụ andụ na usoro ị doụ ọgwụ ọ bụla dị mkpa, yana ịnye onye ọrịa ozi gbasara ọgwụgwọ ahụ.

Onwekwu ike nke hypoglycemia nwere ike ime na ndị a:

• ọjụjụ ma ọ bụ enweghị ike nke onye ọrịa (ọkachasị ndị agadi) ịgbaso ọgwụ ndị dọkịta ma nyochaa ọnọdụ ya,
• nri na-ezughi ezu, na-ezighi ezi, na-eri nri, na-ebu ọnụ ma na-agbanwe nri,
• akpachapụ anya n'etiti ọrụ nkịtị na ego nke carbohydrates,
• gbasara akwara
• nnukwu ikeji imeju
• do overụ ọgwụ ọ theụ Diụ na-arịa Diabeton
• ụfọdụ ọrịa endocrine: ọrịa thyroid, pituitary na adrenal insufficiency,
• N'otu oge, ị certainụ ọgwụ ụfọdụ (lee mpaghara “Mmekọrịta na ọgwụ ndị ọzọ”).

Mgbaaka na imeju imeju
N'ime ndị ọrịa nwere ọrịa ịba ọcha n'anya na / ma ọ bụ ọdịda akụrụngwa, ọgwụ na ọgwụ na / ma ọ bụ ọgwụ ọgwụ nke gliclazide nwere ike ịgbanwe. Ọnọdụ hypoglycemia nke na-etolite na ndị ọrịa nwere ike ịdị ogologo oge, n'ọnọdụ ndị dị otú a, ọgwụgwọ kwesịrị ekwesị ozugbo dị mkpa.

Ozi Ndidi
Ọ dị mkpa ịgwa onye ọrịa ahụ, yana ndị ezinụlọ ya, banyere ihe ize ndụ nke ịmalite hypoglycemia, ihe mgbaàmà ya na ọnọdụ ndị na-eme ka mmepe ya. A ga-agwa onye ọrịa banyere ihe ọghọm na uru ọgwụgwọ ọgwụgwọ chọrọ.
Onye ọrịa ahụ kwesịrị ịkọwa mkpa iri nri dị, mkpa maka mmega ahụ oge niile yana ileba anya n'ọtụtụ glucose ọbara.

Nchịkwa nchịkwa zuru oke
Njikwa glycemic na ndị ọrịa na-enweta ọgwụgwọ hypoglycemic nwere ike ịkụda n'ọnọdụ ndị a: ahụ ọkụ, trauma, ọrịa na-efe efe, ma ọ bụ nnukwu ịwa ahụ. N'ọnọdụ ndị a, ọ nwere ike ịdị mkpa iji kwụsị ọgwụ Diabeton abet MV ma wepụta ọgwụ insulin.
N'ọtụtụ ndị ọrịa, ịdị irè nke ihe ndị na-eme ka hypoglycemic nke ọnụ, gụnyere gliclazide, na-adalata mgbe ogologo oge ọgwụgwọ gasịrị. Mmetụta a nwere ike ịbụ n'ihi ma ọrịa ahụ yana mbelata na azịza ọgwụgwọ ọgwụ. A maara nke a dị ka nkwụghachi ọgwụ nke abụọ, nke a ga-apụrịrị na nke mbụ, nke ọgwụ a anaghị enye nsonaazụ a na-atụ anya na nnọkọ mbụ. Tupu inyocha onye ọrịa nwere ọgwụ mgbochi ọgwụ nke abụọ, ọ dị mkpa iji nyochaa izu oke nke nhọrọ dose na nnabata nnabata na usoro nri.

Nnwale ụlọ nyocha
Iji chọpụta njikwa glycemic, a na-atụ aro mkpebi siri ike nke glucose ọbara na-ebu ọnụ na HbA1c glucose ọbara.
Na mgbakwunye, ọ ga-adị mma ka ị na-eme nyocha onwe onye mgbe niile gbasara nchịkọta glucose ọbara.
Nchịkwa nke Sulfonylurea nwere ike ibute anaemia n'ime hemolytic n'ime ndị ọrịa nwere ụkọ glucose-6-phosphate dehydrogenase. Ebe ọ bụ na gliclazide bụ ihe ana - akpọ sulfonylurea, a ga - elerịrị ya anya mgbe ị na - elekọta ndị ọrịa nwere ụkọ glucose-6-phosphate dehydrogenase.
Ekwesịrị ịkọwapụta ọgwụ hypoglycemic nke otu ọzọ.

NKWU NDEN NA-EKWU NA-EKWESEHREH BAEHB VL NA EHMCHAKA
N'ihi mmepe nke hypoglycemia site na iji ọgwụ Diabeton ® MV, ndị ọrịa kwesịrị ịma ihe mgbaàmà nke hypoglycemia ma kwesịrị ịkpachara anya mgbe ha na-anya ụgbọ ala ma ọ bụ na-arụ ọrụ chọrọ oke ọsọ nke mmeghachi omume anụ ahụ na nke uche, karịsịa na mmalite ọgwụgwọ.

ISI AKA
60 mg agbanwere mbadamba mbugharị
Mbadamba ụrọ iri atọ dị n'otu ọnya (PVC / Al), blister 1 ma ọ bụ abụọ nwere ntuziaka maka ojiji ahụike na kaadiboodu.
Mgbe nkwakọ (nkwakọ ngwaahịa) na ụlọ ọrụ Russia LLC Serdix:
Mbadamba ụrọ iri atọ dị n'otu ọnya (PVC / Al), blister 1 ma ọ bụ abụọ nwere ntuziaka maka ojiji ahụike na kaadiboodu.
Mbadamba iri na ise n'otu ọnya (PVC / Al), blister 2 ma ọ bụ 4 nwere ntuziaka maka iji ọgwụ na ahụ ike na igbe kaadi.
Site na mmepụta na ụlọ ọrụ Russian LLC Serdix
Mbadamba iri na ise n'otu ọnya PVC / Al. Maka blister 2 ma ọ bụ 4 nwere ntuziaka maka ojiji ahụike na otu kaadiboodu.

Ọnọdụ ọnọdụ
Achọghị ọnọdụ nchekwa pụrụ iche.
Mee ka ụmụaka ghara iru.

ELBỌCH SH NSỌ
Afọ 2 Ejila oge emechara ka egosiputara na ngwugwu ahụ.

Usoro EGO
Site na ndenye ọgwụ.

NWA ANYA
Laboratories Servier Mmeputa, France
Serdix LLC, Russia

Akwụkwọ edere aha nke ụlọ ọrụ Servier Laboratories, France; Servier Industries Labs, France

"Ratlọ ọrụ nyocha nke ụlọ ọrụ":
905, Saran awara awara, 45520 Gidey, France
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Maka ajụjụ niile, kpọtụrụ Representativelọ Ọrụ Nlekọta nke JSC “Servier Laboratory”.

Onyinye nke JSC “Laboratory Servier”:
115054, Moscow, Paveletskaya pl. d.2, p. 3

N'ihe banyere nkwakọ ngwaahịa na / ma ọ bụ nkwakọ ngwaahịa / n'ichepụta ihe na LLC Serdiks, Russia
Serdix LLC:
Russia, Moscow

Diabeton MV: ntuziaka maka ojiji (usoro na usoro)

A na-ewere ọgwụ ahụ ọnụ, otu ugboro n'ụbọchị (ọkacha mma n'oge nri ụtụtụ). A naghị akwado ya ka ị ghee ma ọ bụ taa tebụl ahụ.

Thebọchị nke Diabeton MV kwa ụbọchị dịgasị site na 30 ruo 120 mg na otu usoro. Ọ bụrụ n’otu ụbọchị ma ọ bụ karịa ka ọ ga-efu, ị gaghị enwe ike ịbawanye ọgwụ a na-esote ya.

A na-ahọrọ ọ̀gwụ nke ọgwụ n’otu n’otu n’iburu n'uche ihe ngosi dịka ịta nke glucose n’ime ọbara yana ọkwa glycogemoglobin (HbA1c).

Na mbido ọgwụgwọ, a na-edenye Diabeton MV 30 mg kwa ụbọchị (gụnyere ndị agadi agadi 65 afọ na karịa). Site na njikwa zuru oke, enwere ike iji gliclazide dị ka ọgwụ mmezi. N'ihe banyere njikwa glycemic ezughị ezu, enwere ike ịbawanye dose ahụ (usoro) gaa 60 mg, 90 mg ma ọ bụ 120 mg kwa ụbọchị.

Enwere ike ịbawanye ọnụọgụ ahụ mgbe otu ọnwa gachara gliclazide na usoro enyerelarị ya, ewezuga ndị ọrịa ahụ nke ọkwa glucose ọbara agbasaghị mgbe izu abụọ nke iji ọgwụ ahụ. Ndị ọrịa dị otú a nwere ike ịbawanye ọgwụ mgbe izu abụọ nke ọgwụgwọ gasịrị.

Usoro kachasị maka Diabeton MV bụ 120 mg kwa ụbọchị.

Mgbe ị na-agbanwe site na mkpụrụ ọgwụ Diabeton (80 mg nke gliclazide) na Diabeton MV, a na-agbanwe otu mbadamba Diabeton ka ọ bụrụ ọkara mbadamba nke Diabeton MV 60 mg. A na-ebufe ntụgharị a n'okpuru nchịkwa glycemic.

Enwere ike ịrịa Diabeton MV kama ịnwe ọnya hypoglycemic nke ọzọ. Mgbe ị na-ebufe onye ọrịa, a na-atụle usoro nke ọgwụ hypoglycemic ejirila na ọkara ndụ ya. Ọtụtụ mgbe ọ dịghị oge mgbanwe. Ọkwa nke mbụ nke Diabeton MV bụ 30 mg ma na-esochizi ya aha ọ dabere na ọkwa glucose dị n'ọbara.

Ọ bụrụ na onye ọrịa ahụ ejirila ọkara ndụ nke mkpochapụ sulfonylurea, ọ dị mkpa ịkwụsị ọgwụgwọ ruo ọtụtụ ụbọchị ma ọ bụ mgbe nke ahụ gasịrị malitere ịrịa ọrịa mamịrị MV (iji gbochie hypoglycemia, nke nwere ike ibute nsonaazụ mmụba nke ọgwụ hypoglycemic abụọ).

Enwere ike ikpokọta Gliclazide na alfa-glucosidase inhibitors, insulin ma ọ bụ biguanidines.

N'ihe banyere nchịkwa nchịkwa na-ezughị ezu, a na-eme insulin ọgwụ ahụ n'otu oge n'otu nlekọta ahụike.

Maka ndị ọrịa gbara afọ iri isii na ise gbagowe, yana ndị ọrịa nwere obere ahaghị akwara na-emegaghị, ọ dịkwa mkpa ka a gbanwee mgbanwe dose ahụ.

Na ọnụnọ nke contraindications dị iche iche, a na-eji Diabeton MV na usoro dịkarịa ala a tụrụ aro (30 mg kwa ụbọchị).

Nsonaazụ

• usoro nri: ọgbụgbọ, mgbu afọ, vomiting, afọ ntachi ma ọ bụ afọ ọsịsa (ị gụ gliclazide n'oge nri ụtụtụ na-ebelata ohere nke mgbaàmà ndị a),
• imeju na ọnya biliary: ụba ọrụ transaminase na-arụ ọrụ, ikpe ndị dịpụrụ adịpụ - ịba ọcha n'anya (achọrọ ịkwụsị ọgwụgwọ),
• sistemu (lymphatic system) na akụkụ hematopoietic: adịkarịghị - leukopenia, anaemia, granulocytopenia, thrombocytopenia (na-apụ n'anya mgbe ọpụpụ ọgwụ ọjọọ),
• akpụkpọ ahụ na abụba subcutaneous: akpụkpọ ahụ itching, erythema, ihe ọkụ ọkụ, urticaria, maculopapular fash, angioedema, mmeghachi omume jọgburu onwe ya,
• Ahụ akụrụngwa: ọgba aghara nlegharị anya nke anya n'ihi mgbanwe nke ọkwa glucose, ọkachasị na mmalite ọgwụgwọ.

N'oge ọgwụgwọ na Diabeton MV, hypoglycemia nwere ike ịmalite, ọkachasị mgbe nri na-adịghị adị ma ọ bụ na-ahapụ nri ụtụtụ, nri ehihie ma ọ bụ nri abalị. Ihe mgbaàmà hypoglycemia bụ: ọgbụgbọ, agụụ siri ike, ọgbụgbọ, isi ọwụwa, mgbakasị ahụ, mgbanyụ anya, ike ọgwụgwụ, mgbakasị ahụ, mmeghachi omume ụra, ọgba aghara, ịma jijiji, enweghị enyemaka, ịda mba, enweghị isi na ọhụụ, enweghị njide onwe onye, ịda mba, paresis, nghọta na-adịghị mma, nkwarụ, aphasia, bradycardia, iku ume na-emighị emi, nkụchi, adịghị ike, iro ụra, isi ọnwụ, nsụhọ mmụọ, coma (ruo ọnwụ). Ihe mmeghachi adrenergic ndị a nwekwara ike ịpụta: nchekasị, hyperhidrosis, tachycardia, palpitations, angina pectoris, arapara, ọbara mgbali elu na arrhythmia.

Ọtụtụ mgbe, akara nke hypoglycemia na-akwụsị nke ọma site na ị sugarụ shuga (carbohydrates). Ndị na-atọ ụtọ ụtọ adịghị arụ ọrụ. Ọ bụrụ na mgbe mgbaghasịsịsị nke hypoglycemia nwere ihe ịga nke ọma onye ọrịa ahụ na-ewere usoro ọgwụgwọ sulfonylurea ndị ọzọ, nlọghachi nwere ike ibute ya na-emebi ugboro ugboro. N'ihe banyere hypoglycemia ogologo oge ma ọ bụ nnukwu ọrịa, a na-atụ aro nlekọta mberede (ruo ụlọ ọgwụ), ọbụlagodi nnwere onwe nke mgbaàmà site na nchịkwa nke carbohydrates.

Mgbe ụfọdụ ọgwụ nwere ike ibute nsonaazụ ndị a na-esite na usoro ọgwụgwọ sulfonylurea niile: hemolytic anaemia, erythrocytopenia, pancytopenia, hyponatremia, agranulocytosis, vasculitis allergies.

Ntụziaka pụrụ iche

Enwere ike ịnye ndị ọrịa mamịịn MV ọgwụ naanị ndị ọrịa na-adịghị azọsa nri ma rie nri ụtụtụ mgbe niile. Ọ dị mkpa idobe oriri carbohydrates zuru oke site na nri ma zere nri nwere obere carb. Ihe ọghọm hypoglycemia na-abawanye n'okwu ndị a:

• nnukwu ikeji imeju
• gbasara akwara
• ọnụnọ ụfọdụ ọrịa endocrine (adrenal na pituitary insufficiency, ọrịa thyroid),
• oge nri na adighi nma, nri onu, iri nri, mgbanwe nri,
• akpachapụghị anya n'etiti oke carbohydrates wetara nri na mmega ahụ,
• n'otu oge iji ụfọdụ ọgwụ (lee mpaghara "Mmekọrịta Ọgwụ"),
• nnyefere nke gliclazide,
• enweghi ike ma ọ bụ jụ onye ọrịa (ọkachasị na agadi) ịchịkwa ọnọdụ nke ya ma soro ntuziaka dọkịta.

A na-anabata ike nchịkwa glycemic na ndị ọrịa nwere mmerụ ahụ, nnukwu ịwa ahụ, ọrịa na-efe efe ma ọ bụ ahụ ọkụ. N'ọnọdụ ndị a, enwere ike ịchọ mwepu Diabeton MV na nchịkwa nke insulin.

N'ime ọtụtụ ndị ọrịa, ịdị mma nke ndị na - ahụ maka hypoglycemic nke nchịkwa ọnụ nwere ike ibelata ka oge na-aga (nke a na-akpọ ọgwụ mgbochi nke abụọ).

Mkparịta ụka ọgwụ ọjọọ

A na - eme ka mmetụta nke gliclazide na iji n'otu oge na miconazole (a na - egbochi ngwakọta a, ebe ọ nwere ike iduga mmepe nke coma), phenylbutazone na ethanol (a na - eme ka mmetụta hypoglycemic dịkwuo elu).

N'ihi ihe ize ndụ nke hypoglycemia, ekwesịrị iji Diabeton MV kpachara anya na ọgwụ ndị na-esote: hypoglycemic waki (acarbose, insulin, thiazolidinediones, metformin, dipeptidyl peptidase-4 inhibitors), fluconazole, beta-adrenergic igbochi ndị na-ahụ maka ya, ndị na-eme mmụọ, ndị na-achọghị, ọgwụ mgbochi mkpali, ọgwụ mgbochi histamine H₂ndị na-anabata ya, ndị na-egbochi monoamine oxidase.

Mmetụta nke gliclazide na-akụda Danazol (a naghị atụ aro ngwakọta a), chlorpromazine, glucocorticosteroids n'otu oge na tetracosactide na beta₂-adrenomimetik. A na-eji ọgwụ ndị a akpachara anya na n'okpuru nchịkwa nchịkwa.

Gliclazide nwere ike ịkwalite nsonaazụ anticoagulants.

Ihe analogues Diabeton MV bu Gliclazide MV, Gliclazide-AKOS, Gliclazide Canon, Gliclazide MV Pharmstandard, Golda MV, Glidiab, Gliklada, Diabetalong, Glidiab MV, Diabefarm, Glyclazid-SZ, Diabinax, Diabinax, Diabinax, Diabinax, Diabinax, Diabinax

Nyocha banyere Diabeton MV

Ndị ọrịa na-ahapụ nyocha dị mma gbasara Diabeton MV. Nke a bụ ọgwụ dị irè n'ezie nke na-enyere aka ịnọgide na-enwe ọ̀tụ̀tụ̀ shuga dị n'ọbara nkịtị. Gliclazide adịkarịghị akpata mmeghachi ahụ nfụkasị na mmetụta ndị ọzọ. Ọ dị mma ị were mbadamba mbadamba, ebe ọ bụ na a na-eme usoro kwa ụbọchị maka otu ọgwụ. Ọgwụ Diabeton MV bụ ụzọ dị mma maka ọgwụgwọ insulin.

Cons nke ọgwụ, dị ka ndị ọrịa: ọ dị mkpa inye ụmụ aka, ihe ize ndụ nke hypoglycemia, ọnụ ahịa dị elu, mmeghachi omume onwe onye na gliclazide.