Ntụziaka maka iji ọgwụ Metformin

Metformin bụ ọgwụ ọnụ hypoglycemic ọgwụ maka ịgwọ ụdị ọrịa shuga 2.

Ọgwụ ahụ na-egbochi gluconeogenesis na imeju, na-ebelata nnabata nke glucose site na eriri afọ, na-eme ka ojiji nke glucose na-emetụta oge, na-emekwa ka ikike nke anụ ahụ nwee insulin.

Ọ naghị emetụta nzuzo nke insulin site na mkpụrụ ndụ beta nke pancreas, anaghị akpata mmeghachi omume hypoglycemic.

Ọ na-ebelata ọkwa nke thyroid na-akpali homonụ n'ime ọbara ọbara, ọkwa nke cholesterol na obere lipoproteins dị ala, na-egbochikwa mgbanwe mgbanwe na akwara ọbara.

Ojiji nke Metformin na-enyere aka weghachite coagulability ọbara, meziwanye ihe ọmụmụ ya, yana belata ohere nke thrombosis. Ihe mgbakwunye na-eso akpata oke ibu oke ibu.

Mejupụtara Metformin (mbadamba 1):

• Metformin - 500 mg
• Ndị ọpụpụ: povidone, stachi ọka, crospovidone, magnesium stearate, talc,
• Ihe mejupụtara shell: methaclates acid na methyl methacrylate copolymer, macrogol, titanium dioxide, talc.

Ihe ngosi maka ojiji

Gịnị bụ Metformin maka? Dabere na ntuziaka ndị ahụ, edepụtara ọgwụ ahụ n'okwu ndị a:

• Dika otu ogwu eji eme ihe na ndi mmadu nwere oria nke 2 n’enweghi udiri ketoacidosis na enweghi nsogbu usoro nri (karisia ndi oria buru oke ibu).
• Na insulin, a na-eji ọgwụ ahụ eme ihe maka ụdị ọrịa shuga mellitus nke 2, nke a na-ejikọ na insulin nke na-egbochi ya (karịchaa ndị ọrịa nwere oke oke ibu).

Ntụziaka maka iji Metformin, usoro onunu ogwu

Ekwesịrị ị takenụ ọgwụ ahụ n'ọnụ na-enweghị ata ata mbadamba ụrọ n'oge nri ma ọ bụ ozugbo nri. A na-edozi usoro onunu ogwu ọ bụla maka onye ọrịa ọ bụla, dabere na nyocha nke ọkwa glucose ọbara.

Ọgwụ nke mbụ maka ndị okenye nke Metformin tụrụ aro bụ 500 mg site na 1 ruo ugboro atọ kwa ụbọchị ma ọ bụ 850 mg site na 1 ruo 2 ugboro n'ụbọchị. Ọ bụrụ na ọ dị mkpa, na etiti oge nke izu 1, a na-eji nwayọ elu onunu ogwu ihe ruru 2000-3000 mg.

Oru kachasị na-anabata kwa ụbọchị maka ndị ọrịa bụ 1000 mg.

Usoro ọgwụgwọ maka ụmụaka ruru afọ 10 bụ 500 ma ọ bụ 850 mg 1 oge kwa ụbọchị ma ọ bụ 500 mg ugboro 2 kwa ụbọchị. Ọ bụrụ na ọ dị mkpa, a na-eji nwayọọ nwayọọ na-abawanye kwa ụbọchị, ruo 2000 mg na 2-3 usoro.

Mgbe ị na-eme ọgwụgwọ ngwakọta, ọgwụ Metformin dịka ntuziaka ahụ si si na 500 ruo 850 mg ugboro abụọ kwa ụbọchị. A na-ahọrọ usoro nke insulin n'otu n'otu dabere ogo glucose dị n'ọbara.

A na-ahụta ọgwụ kachasị na plasma ọbara 2,5 awa 2.5 mgbe nchịkwa gasịrị, mgbe awa 6 gachara ọ ga-agbada. Mgbe ụbọchị 1-2 gachara, ị na-etinye ọgwụ ị inụ ọgwụ mgbe niile.

Recommendedmeghari usoro onunu ogwu ka odi ka ubochi 7 ruo 15 nke mbido ogwu ahu.

N'ihi ịba ụba nke lactic acidosis, a ga-ebelata dose ahụ na nsogbu metabolic siri ike.

Nsonaazụ

Ntụziaka ahụ dọrọ aka ná ntị banyere ihe nwere ike imepụta nsogbu ndị a na-esochi mgbe ị na-edepụta Metformin:

• Usoro nri (uto) - uto dị n'ime ọnụ, ọgbụgbọ, ọgbụgbọ oge, mgbu afọ, afọ ọsịsa, agụụ maka nri ya ruo mgbe ọnụnọ ya zuru oke (anorexia), flatulence (ịba ụba gas na-aba n’ime eriri afọ).
• Usoro endocrine bụ hypoglycemia (mbelata n'ọbara shuga ọbara n'okpuru nkịtị).
• Metabolism - lactic acidosis (ịba ụba nke lactic acid n'ime ọbara), na-emetụta vitamin B12 site na eriri afọ.
• Ọbara ọbara na agịga ọbara - megaloblastic anaemia (anaemia metụtara mebiri ma tokwaa sel sel ọbara n’arụ ọbara ọbara n’ihi ezughị vitamin B12) ezughi oke).
• Mmeghachi omume nfụkasị ahụ - ọnya ọnya na itching.

Mmetụta ndị dị na akụkụ eriri afọ na-etolite na mmalite ọgwụgwọ na ọgwụ ahụ ma kwụsị n'onwe ha. Iji belata ogo mgbaàmà ozugbo enwere ike, ọgwụ ọgwụ antacids, antispasmodics na ọgwụ ndị dị ka ọgwụroprop-dị ka dọkịta nyere.

Ihe ngbanwe

A na - egbochi Metformin n'ọnọdụ ndị a:

• Imeju ma ọ bụ arụ ọrụ akụrụ arụ,
• Lactic acidosis (gụnyere akụkọ ihe mere eme)
• Ọrịa mamịrị ketoacidosis
• Mmanya na-egbu egbu ma ọ bụ egbu egbu ị ,ụ mmanya.
• Ọrịa shuga, prema,
• Egosiputara nke oma site na oria na ala oria nke puru ibu mmepe nke hypoxia aru (dika imaatu, iku ume ma obu akwara nke odida, nsogbu myocardial infarction).
• Nnabata na nri hypocaloric (mgbe ị na -eri obere calorie 1000 kwa ụbọchị).
• Ọrịa ọria nke nwere nsogbu itolite akụrụ, dịka ọmụmaatụ, akpọnwụ akpịrị na vomiting ma ọ bụ afọ ọsịsa, ọrịa na-efe efe, ahụ ọkụ, hypoxia (ya na ọrịa bronchopulmonary, ọrịa akụrụ, sepsis, ujo),
• Ngwa dị ka ụbọchị abụọ tupu yana n’ime ụbọchi abụọ mgbe nyochachara redio ma ọ bụ redioisotope na iwebata ihe dị iche nwere ayodiin,
• Nnukwu ọnya na ịwa ahụ (n'ọnọdụ ebe achọrọ insulin),
• Ime na lactation
• Ọnụnọ nke hypersensitivity na metformin hydrochloride ma ọ bụ akụrụngwa inyeaka ọ bụla.

Jiri nlezianya dọọ ndị mmadụ ihe karịrị afọ 60 na-arụ nnukwu ọrụ ahụ (ihe egwu nke ịmalite lactic acidosis).

Dodoụbiga ya ókè

N'ihe banyere ịdoụbiga mmanya ókè, lactic acidosis nwere ike ịmalite, mgbaàmà - ọgbụgbọ, ọgbụgbọ, mgbu akwara, afọ ọsịsa, mgbu afọ. Ọ bụrụ na enyereghị ya aka n'oge ọ kara aka, obi nkoropụ, mmụọ na-adịghịzi mma ma ọ bụ akpịrị.

Thezọ kachasị dị irè iji wepụ metformin n'ahụ ahụ bụ hemodialysis. Na-esote, a na-enye ọgwụ usoro ọgwụgwọ Symptomat

Analogs Metformin, ọnụahịa dị na ụlọ ahịa ọgwụ

Ọ bụrụ na ọ dị mkpa, ịnwere iji dochie Metformin iji ihe dị n'ọrụ - ndị a bụ ọgwụ ọjọọ:

Mgbe ị na-ahọrọ analogues, ọ dị mkpa ịghọta na ntuziaka maka ojiji nke Metformin, ọnụahịa na nyocha anaghị emetụta ọgwụ nwere mmetụta yiri ya. Ọ dị mkpa ịnweta ndụmọdụ nke dọkịta na ịghara ime mgbanwe ọgwụ ọ bụla.

Ọnụahịa dị na ụlọ ahịa ọgwụ Russia: Metformin 500 mg 60 mbadamba 60 - site na 90 ruo 120 rubles, mbadamba Metformin Zentiva 850 mg 30 - sitere na 93 ruo 149 rubles, ọnụ ahịa nke Metformin canon 500 mg 60 mbadamba 60 - site na 130 ruo 200 rubles, dị ka ọgwụ 726 si kwuo.

Na-echekwa n'ebe nkụkpọghị ụmụaka aka na okpomọkụ nke + 15 ... + 25 Celsius. Ndụ shelf bụ afọ 3.

Omume ọgwụ

Metformin bụ ihe eji eme klas. biguanides, usoro ọrụ ya gosipụtara n’ihi igbochi usoro gluconeogenesis n’ime imeju, ọ na-ebelata nnabata glucose site na eriri afọ, na-eme ka usoro glucose ike dịkwuo elu, na-abawanye ogo nke anụ ahụ na-eme ihe. insulin. Ọ dịghị emetụta usoro insulin insulin site na mkpụrụ ndụ beta nke pancreas, anaghị akpalite ngosipụta nke mmeghachi omume hypoglycemic. N'ihi ya, ọ na-akwụsị hyperinsulinemia, nke bụ ihe dị mkpa na-enyere aka ịba ụba ma nwee ọganihu nke nsogbu akwara oria shuga. N'okpuru mmetụta ya, ịdị arọ nke anụ ahụ na-eme ka ọ kwụghachi ma ọ bụ belata.

Ngwá ọrụ belata ọdịnaya n’ime ọbaratriglyceridesna linoproteinsnjupụta dị ala. Na -ebelata ọnụego abụba, na - egbochi mmepụta nke abụba n'efu. Achọpụtara mmetụta nke fibrinolytic, na-egbochi PAI-1 na t-PA.

Ọgwụ a na - egbochi ọgwụ ịba ụba nke akwara anụ ahụ. Mmetụta dị mma na steeti sistemụ akwara, na-egbochi mmepe ọrịa shuga na-arịa ọrịa mamịrị.

Mwepụta wepụtara ya na ihe mejupụtara

Mbadamba ụrọ enteric, Metformin nwere ọdịdị gbara ya gburugburu, ihu biconvex na agba ọcha. Ihe kachasị dị mkpa nke ọgwụ ahụ bụ metformin hydrochloride, ọdịnaya ya na mbadamba 500 bụ mg. Ọzọkwa, ihe mejupụtara ya gụnyere ihe inyeaka, nke gụnyere:

• Crospovidone.
• Talc.
• Stereta magnesium.
• Ọka ọka.
• Methaclates acid na methyl methacrylate copolymer.
• Povidone K90.
• Titanium dioxide
• Macrogol 6000.

A na-etinye mbadamba Metformin na ngwungwu na-acha uhie uhie 10. Mpempe kaadiboodu nwere blisters 3 (mbadamba 30) na nkọwapụta maka iji ọgwụ ahụ.

Gịnị bụ Metformin maka?

Iri mbadamba Metformin ka egosiri iji belata mkpokọ glucose na ọbara na ụdị ọrịa shuga na-abụghị insulin na - enweghị ọgwụgwọ ọgwụgwọ site na nhazi nri. A na-ejikwa ọgwụ a na insulin maka ụdị ọrịa shuga dị n'ọrịa 2 nke ukwuu, karịsịa na ndị nwere oke ahụ ha.

Ihe ngbanwe

Iwere mbadamba nkume Metformin na ọnụnọ nke ọnụọgụ ọrịa na ahụ ike nke anụ ahụ, nke gụnyere:

• Ejikọtara onwe ya na ihe na-arụ ọrụ ma ọ bụ ihe enyemaka nke ọgwụ ahụ.
• Ketoacidosis nke na-arịa ọrịa shuga (akara nke ọbara glucose dị n'ọbara ya na mgbanwe nke metabolism na nchịkọta anụ ahụ ketone n'ime ahụ), precoa na-arịa ọrịa shuga na coma (mmetụ mmụọ na-emegide ihe ndabere nke ogo glucose dị elu).
• Ọrụ akụrụ na arụ ọrụ.
• Nnukwu ọrịa, nke na-eso nnukwu ihe gbasara ọdịda akwara - akpịrị ịkpọ nkụ (akpịrị ịkpọ nkụ) nke anụ ahụ na oke afọ ọsịsa, vomiting, ọrịa na-efe efe na oke egbu egbu na ahụ ọkụ.
• Ọnọdụ hypoxia na sepsis (nsị ọbara), nnukwu myocardial infarction (ọnwụ nke akụkụ akwara obi), obi ma ọ bụ akụkụ iku ume.
• Ventionsmepụta usoro ịwa ahụ volumetric, merụrụ ahụ nke ukwuu, na-achọ iwebata insulin maka ịmaliteghachi ngwa ngwa (ọgwụgwọ) nke anụ ahụ na mpaghara mmebi.
• Imebi ọrụ dị na imeju.
• Ngwa n'ime ụbọchị abụọ tupu ma ọ bụ mgbe redioisotope na ọmụmụ redio nke anụ ahụ jikọtara ya na ntinye nke isotope redioaktivu redio nke ayodiin.
• Lactic acidosis (mmụba nke ọkwa lactic acid n'ime ọbara, ihe sochiri mgbanwe na mmeghachi omume ya n'akụkụ acidic), gụnyere oge gara aga.
• Nnabata nri nwere kalori (n'okpuru 1000 kcal kwa ụbọchị).
• Ime ime n’oge ọ bụla n’agụmakwụkwọ na inye nwa ara.

N'iji nlezianya, a na-eji mbadamba Metformin mee ihe na ndị mmadụ karịa afọ 60 ma ọ bụ megide mmalite nke arụ ọrụ anụ ahụ (nnukwu ihe ọghọm nke mmụba nke mkpokọta lactic acid n'ọbara) Tupu ị takingụ ọgwụ ahụ, ịkwesịrị ijide n'aka na enweghi ọgwụ mgbochi.

Usoro onunu ogwu na nhazi

Iri mbadamba Methodin ka a na -ewere ọnụ site na nri ma ọ bụ ozugbo ewere ya. Edekwala mbadamba nkume ma drinkụọ mmiri dị ukwuu. Iji belata ohere mmadụ nwere ibia ihe ojoo site na usoro nri, a na-ewere kwa ụbọchị, na-ekewa n'ime usoro 2-3. Dọkịta debere usoro na usoro ọgwụ ahụ n’otu n’otu, dabere na nnabata shuga dị n’ọbara, yana nrụpụta ọgwụgwọ. Dịka ọ dị, usoro ịmalite bụ 500-1000 mg kwa ụbọchị (mbadamba 1-2). Mgbe ụbọchị 10-15 gachara, dabere n'ọkwa glucose dị n'ọbara, ọ ga-ekwe omume ịbawanye usoro onyonyo nke Metformin na 1500-2000 mg kwa ụbọchị. Usoro onunu ogwu kacha elu kwa ubochi kariri 3000 mg. N'ime ndị okenye, ọgwụ kachasị elu kwa ụbọchị ekwesịghị gafere 1000 mg.

Ntụziaka pụrụ iche

Tupu ị were mbadamba Metformin, ị ga-eji nlezianya gụọ ntuziaka maka ọgwụ. Enwere ọtụtụ ntuziaka akọwapụtara maka ojiji ya, nke gụnyere:

• Site na ngosipụta nke mgbu olu (myalgia) mgbe mmalite nke ọgwụ ahụ, a na-eme mkpebi nyocha nke ọkwa lactic acid na ọbara.
• Ogologo oge iji ogwu a choro nlekota oge nke ndi na-egosi ulo oru nke akuru nke aru.
• Site na iji mkpụrụ osisi Metformin na-ejikọ ọnụ yana ọgwụ ndị a na-enweta na sulfonylureas, ọ dị mkpa ilezi anya nke ọma ka a na-elele glucose ọbara n'ọtụtụ oge.
• N'oge ị na-agwọ ọrịa, kwesịrị ị fromụ mmanya na ọgwụ nwere ethanol.
• Mpempe akwụkwọ Metformin nwere ike iso ọgwụ ndị ọzọ na-emekọrịta ọgwụ, ya mere, mgbe ị na-ewere ha, ọ dị mkpa ịdọ dọkịta na-aga ịga aka banyere nke a.
• Ọ bụrụ na ihe mgbaàmà nke bronchopulmonary na ọrịa ọrịa genitourinary pụtara na ndabere nke ị theụ ọgwụ ahụ, a ga-akwụsị iji ya ma gakwuru dọkịta.
• Ọgwụ ahụ anaghị emetụta ọrụ ọrụ nke ụbụrụ ụbụrụ, Otú ọ dị, mgbe ejiri ọgwụ ndị ọzọ na-ebelata shuga, ihe ize ndụ nke hypoglycemia na-abawanye, yabụ, mgbe ị na-arụ ọrụ metụtara mkpa maka itinye uche dị ukwuu na ọsọ nke mmeghachi omume psychomotor, o kwesịrị ịkpachara anya.

Na netwọsị ahịa ọgwụ, mbadamba Metformin dị na ndenye ọgwụ. Agaghị akwado nchịkwa onwe onye na-enweghị ọgwụ kwesịrị ekwesị.

Dodoụbiga ya ókè

Site na ngafe dị ukwuu nke ọgwụ ọgwụgwọ Methodin a tụrụ aro ya, ịtalata lactic acid n'ọbara na-ebili (lactic acidosis). Ihe a bụ ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, mbelata nke ahụ, mgbu olu na afọ, yana iku ume ngwa ngwa. N'okwu a, ekwesịrị ịkwụsị ọgwụ ahụ. A na-eme ọgwụgwọ a doụbiga ihe ọ inụ Overụ n'ụlọ ọgwụ site n'enyemaka nke hemodialysis (ịsachapụ ngwanrọ nke ọbara).

Dika ihe di ike na aru oru, ogwu Metfogamma, Glucofage, Formmetin bu nke ozo ndi ozo banyere Metformin.

Pharmacokinetics na pharmacodynamics

Mgbe ejiri ọnụ kwuo Metformin, a na-achọpụta ịta ahụhụ kachasị na plasma mgbe awa 2.5 gachara. N'ime ndị na-anata ọgwụ n'ọtụtụ doses, ọdịnaya kachasị elu nke akụrụngwa nọ n'ọrụ na plasma adịghị elu 4 μg / ml.

Mwepu nke akụrụngwa nọ n'ọrụ na-akwụsị 6 awa mgbe nchịkwa gasịrị. N'ihi nke a, itinye uche plasma na-ebelata. Ọ bụrụ na onye ọrịa ahụ ewere ọgwụ ole a tụrụ aro ya, mgbe ụbọchị 1-2 gachara, a na-ahụta ịkwụsi ike mgbe niile nke ihe na-arụ ọrụ na plasma na oke 1 μg / ml ma ọ bụ obere.

Ọ bụrụ na a theụrụ ọgwụ n’oge nri, mgbe ahụ, nnabata nke ihe nọ n’ọrụ na-ebelata. Ọ na-agbakọta tumadi na mgbidi nke ọkpọkọ nri.

Ọkara ndụ ya dị ka awa 6.5. Ogo bioavailability dị na ahụike mmadụ bụ 50-60%. N'inye protein ndị na-enye plasma, mmekọrịta ya na-eleghara anya. Ihe dịka 20-30% nke ọgwụ ahụ na-apụta site na akụrụ.

Nsonaazụ

Ọtụtụ mgbe, mgbe ị na-a theụ ọgwụ ahụ, a na-egosipụta mmetụta ndị ọ na-arụ na ọrụ ndị ahụ usoro nri: ọgbụgbọ afọ ọsịsavomiting, mgbu afọ, akawanye njọ agụụỌdịdị dị ụtọ n'ụdị n'ọnụ. Dịka iwu, mmeghachi omume ndị dị otú a na-etolite n'oge mbụ ị takingụ ọgwụ. N'ọnọdụ ka ukwuu, ha ga-apụ n'anya ọzọ n'iji ọgwụ ọzọ.

Ọ bụrụ na mmadụ nwere mmetụta dị oke elu na ọgwụ ahụ, mmepe nke erythema ga-ekwe omume, mana nke a na-eme naanị n'oge ọ na-adịghị ahụkebe. Site na mmepe nke mmetụta dị ụkọ - erythema agafeghị oke - ọ dị mkpa iji kagbuo nnabata.

Site n'ọgwụgwọ ruo ogologo oge, ụfọdụ ndị ọrịa na-akawanye njọ nke usoro nnabata. vitamin b12. N'ihi ya, ọkwa ya na serum na-agbada ọbaranke ahụ nwere ike ibute imebi hematopoiesis na mmepe megaloblastic anaemia.

Mbadamba ụrọ Metformin, ntuziaka maka ojiji (usoro na usoro onunu ogwu)

Ọ dị mkpa ilo mbadamba ihe nile ma themụọ ya na nnukwu mmiri. Ha na-a theụ ọgwụ ahụ mgbe ha risịrị nri. Ọ bụrụ na ọ na-esiri mmadụ ike ilo mbadamba 850 mg, enwere ike ekewa ya abụọ, a na-ewere ya ozugbo, otu na nke ọzọ. Na mbu, a na-ewere onunu ogwu nke 1000 mg kwa ubochi, a gha ekewa ogwu a ka ogwu abuo ma obu ato iji zere nsogbu ndi ozo. Mgbe ụbọchị 10-15 gachara, a na-eji nwayọ nwayọ elu ya. Nkwekọrịta kachasị anabata nke 3000 mg nke ọgwụ kwa ụbọchị.

Ọ bụrụ na ndị okenye na-ewere Metformin, ọ dị mkpa ka ha nyochaa akụrụ ha mgbe niile. Enwere ike ịnweta usoro ọgwụgwọ zuru oke mgbe izu abụọ gachara ịmalite ọgwụgwọ.

Ọ bụrụ na ọ dị mkpa, bido Metụ ọgwụ Metformin mgbe ị takingụchara ọgwụ hypoglycemic ọzọ maka nchịkwa ọnụ, ị ga-ebu ụzọ kwụsị ị treatmentụ ọgwụ a, wee malite ị Metụ Metformin na usoro usoro akọwapụtara.

Ọ bụrụ na onye ọrịa ahụ jikọtara insulin na Metformin, mgbe ahụ n’ụbọchị ole na ole mbụ, ịkwesighi ịgbanwe insulin na-emebu. Ọzọkwa, enwere ike belata ntụtụ nke insulin n'okpuru nlekọta nke dọkịta.

Ntuziaka maka iji Metformin Richter

Dọkịta setịpụrụ ọgwụ nke ọgwụ ahụ, ọ dabere na glucose ọbara onye ọrịa. Mgbe ị na-ewere mbadamba 0,5 g, ọgwụ mbụ bụ 0,5-1 g kwa ụbọchị. Ọzọkwa, enwere ike ịbawanye dose ahụ ma ọ bụrụ na ọ dị mkpa. Oke kachasị elu kwa ụbọchị bụ 3 g.

Mgbe ị na-ewere mbadamba 0.85 g, ọgwụ mbụ bụ 0.85 g kwa ụbọchị. Ọzọkwa, ọ bụrụ na ọ dị mkpa, a na-abawanye. Ọgwụ kachasị elu bụ 2.55 g kwa ụbọchị.

Mmekorita

Ekwesịrị ijikọ usoro Metformin na sulfonylurea n'ihi ihe ize ndụ nke hypoglycemia.

A na-ebelata hypoglycemic mmetụta mgbe ị na-ewere systemic na mpaghara glucocorticosteroids, glucagon, sympathomimetics, gestagens, adrenaline, homonụ gland thyroid estrogennkwekọrịta nke nicotinic acid, thiazide diuretics, phenothiazines.

Mgbe na-ewere Cimetidine Nwepu nke metformin n’anwụ na-eji nwayọ nwayọ, n’ihi nke a, ọghọm nke igosipụta lactic acidosis na-abawanye.

Mmetụta hypoglycemic bụ nke agon2-adrenergic receptor antagonists, antiotensin-converting factor inhibitors, ndị a na-akpọ clofibrate, inhibitors monoamine, na-abụghị steroidal anti-inflammatory ọgwụ na oxytetracycline, cyclophosphamidesitere na usoro cyclophosphamide.

Mgbe ị na-eji ọgwụ ọgbụgba ma ọ bụ ọgwụ akwara iche na ọdịnaya ayodiin, nke a na-eji maka ọmụmụ X-ray, ya na Metformin, onye ọrịa ahụ nwere ike ịmalite gbasara akwara, na-emekwa ka ohere nke lactic acidosis belata. Ọ dị mkpa ịkwụsịtụ nnabata tupu usoro a, n'oge ya yana ụbọchị abụọ agachara. Ọzọkwa, enwere ike weghachi ọgwụ ahụ mgbe ana-elele ọrụ akụrụngwa ugboro ugboro ka ọ dị ka ọ dị.

Mgbe ị na-ewere ọgwụ mgbochi chlorpropamazine n'ọtụtụ ọnụọgụ, glucose ọbara na-abawanye na ịhapụ insulin na-egbochi. N'ihi ya, mmụba nke ọgwụ insulin nwere ike ịdị mkpa. Ma tupu nke ahụ, ọ dị mkpa ijikwa glucose ọbara gị.

Iji zere hyperglycemiaekwesighi ijikọ ya Danazol.

Na concomitant ogologo oge were na metformin Vancomycin, Amilorida, Quinine, Morphine, Quinidine, Ranitidine, Cimetidine, Procainamide, Nifedipine, Triamterena plasma ịta metformin na-abawanye site na 60%.

Ndinye Metformin na-akwụsịlata Gua na Cholestyramine, ya mere, mgbe ị na-a drugsụ ọgwụ ndị a, ịdị irè nke metformin na-ebelata.

Na-eme ka mmetụta nke anticoagulants dị n'ime, nke dị na klas coumarins.

Analogs nke Metformin

Metformin analogues bụ ọgwụ Metformin Hydrochloride, Metformin Richter, Metformin teva, Bagomet, Formethine, Metfogamma, Glyformin, Metospanin, Siofor, Glycometer, Glycon, Vero Metformin, Orabet, Glyminfor, Ọrịa, Novoformin. Enwekwara otutu ogwu ogwu nke nwere mmetuta ahu di otua (Glibenclamide wdg), mana ya na ihe ndi ozo na aru oru.

Ngwa Mgbakwunye Metformin

N’agbanyeghi eziokwu na ogbako nke Metformin Richter na ihe ndi ozo na anata nyocha banyere Metformin maka oke ibu, ebuputaghi ihe eji eme ihe a. ibu ibu. A na-eji ọgwụ a maka oke ibu n’ihi nsonaazụ ya na mbelata ọbara shuga yana mbelata ọnụ n’ahụ. Agbanyeghị, ị nwere ike ịmụ maka otu esi ewere Metformin maka oke ibu naanị site na isi mmalite ndị a na-atụkwasịghị obi na netwọkụ, ebe ndị ọkachamara anaghị atụ aro ka eme nke a. Agbanyeghị, ị losingụ ọgwụ were ọgwụ nwere ike oge ụfọdụ ga - ekwe omume mgbe ụfọdụ maka ndị na - akpọ Metformin iji gwọọ ọrịa shuga.

Nyocha banyere Metformin

Nyocha banyere Metformin na mbadamba ihe site na ndị ọrịa ahụ nwere ọrịa mellitus nke ọrịa shuga na-egosi na ọgwụ dị irè ma na-enye gị ohere ịchịkwa ọkwa glucose. Nzukọ ndị ahụ nwekwara ntụle nke ịdị mma dị mma mgbe ejiri ọgwụ a maka PCOS. Mana ọtụtụ mgbe enwere nyocha na echiche banyere otu ọgwụ Metformin Richter, Metformin teva ndị ọzọ na-enye gị ohere ijikwa oke anụ ahụ.

Ọtụtụ ndị ọrụ na-akọ na ọgwụ nwere metforminnyeere aka n’ezie ịnagide ego ndị ọzọ. Ma n'otu oge ahụ, a na-egosipụta mmetụta ndị ọ bụla metụtara ọrụ eriri afọ. N'ime usoro a na-atụle etu esi eji metformin eme ihe maka ịdị felata, echiche ndị dọkịta na-abụkarị ihe na-adịghị mma. Ha na-adụ ọdụ ike megide iji ya maka nzube a, yana ị drinkingụ mmanya n'oge usoro ọgwụgwọ.

Ọnụahịa Metformin, ebe ị ga-azụ

Ọnụahịa Metformin n'ụlọ ahịa ọgwụ na-adabere na ọgwụ na nkwakọ ngwaahịa ya.

Ọnụahịa Metformin teva 850 mg averages 100 rubles kwa ngwugwu 30 PC.

Buyzụta Metformin Canon 1000 mg (60 pcs.) Nwere ike ịbụ maka 270 rubles.

Ego ole bụ Metformin, dabere na ọnụ ọgụgụ mbadamba na ngwugwu: 50 PC. You nwere ike ịzụta na ọnụahịa nke 210 rubles. Ekwesiri iburu n’uche mgbe ị na-azụrụ ọgwụ maka oke ibu nke ọgwụ rere ya.

Usoro onunu ogwu na nhazi

Mkpebi Metformin kpebiri site na dọkịta n’otu n’otu, dabere na ịba ụba nke glucose n’ime ọbara, a na-ewere mbadamba ihe ọnụ, dum, n’oge ma ọ bụ ozugbo nri, yana obere mmiri mmiri. Iji belata ihe ọghọm nke nsonaazụ si eriri afọ, a na-atụ aro ka emee kwa ụbọchị ka ọ bụrụ nke abụọ.

Ọgwụ nke mbụ bụkarị 500-1000 mg kwa ụbọchị, ma ọ bụrụ na ọ dị mkpa (dabere na nsonaazụ nke mkpebi nke glucose n'ọbara) mgbe ụbọchị 10-15 gachara, ọ nwere ike jiri nwayọ mụbaa. Uzo eji edozi ugwọ ogwu n’odi ikpe bu 1500-2000 mg kwa ubochi, oke nke ubochi ekwesighi kari 3000 mg.

A na-atụ aro ka ndị ọrịa nke afọ agadi ghara ịfe ihe karịrị 1000 mg kwa ụbọchị.

Na nsogbu ọrịa metabolic siri ike, n'ihi oke ụjọ nke lactic acidosis, a ga-ebelata ọgwụ Metformin.

Mkparịta ụka ọgwụ ọjọọ

Site na nhazi oge nke ọgwụ ahụ na antipsychotics ma ọ bụ danazole, yana mgbe ha gụchara akwụkwọ ha, achọrọ ka ịchịkwa ọkwa nke glycemia ma dozie nnabata nke Metformin.

Ekwesiri iburu n'uche na mgbe ejiri ya na metformin:

• Ngwurugwu Sulfonylurea, insulin, acarbose, ọgwụ mgbochi anti-mbufụt (NSAIDs), oxytetracycline, monoamine oxidase inhibitors (MAOs), cyclophosphamide, Clofibrate sitere, angiotensin na-agbanwe enzyme inhibitors (ACEs), gic-agren
• Chlorpromazine - enyere aka na oke onunu (100 mg / ụbọchị) ịbawanye glycemia, belata ntọhapụ nke insulin,
• Cimetidine - na-egbu oge ikpochapụ metformin, si otú a na-abawanye ihe ize ndụ nke lactic acidosis,
• Ihe mgbochi oral, glucocorticosteroids (GCS), epinephrine, glucagon, sympathomimetics, homonụ thyroid, ọgwụ nicotinic acid, ọgwụ phenothiazine, thiazide na loop diuretics belata mmetụta hypoglycemic.

Metformin na-akụda ịdị irè nke anticoagulants (ọgwụ coumarin).