Presartan N

Ọgwụ nwere mmetụta antihypertensive, na-ezo aka ọgwụ, nke bụ ihe mgbochi akọwapụtara. angiotensin ndị na-anabata ihe (ụdị AT1) Ọ dịghị egbochi enzyme (kinase II) na-emebi bradykinin. Presartan na-ebelata ịta ọbara aldosterone na norepinephrine, OPSS, EGO, na-ebelata oke ibu, mgbali ke “obere” okirikiri mgbasa ọbara, nwere mmetụta diuretic. Ọ na-egbochi mmepe nke hypertrophy myocardial. Na ndị ọrịa na- CHF na-abawanye iguzogide mmega ahụ.

Mgbe otu ọgwụ Presartan kwụsịrị, mmetụta antihypertensive na-erute uru kachasị ya mgbe elekere 6 gachara, jiri nwayọ belata ụbọchị na-esote. A na-egosipụta mmetụta kachasị hypotensive na nkezi otu ọnwa mgbe mmalite ọgwụgwọ ọgwụ.

Presartan, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

A na-ewere Presartan n'agbanyeghị nri nri, otu oge kwa ụbọchị. Na ọgwụgwọ ọbara mgbali ike ọgwụ a tụrụ aro kwa ụbọchị nke 50 mg, nke, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ibu na 100 mg. N'ihe banyere onye ọrịa ahụ na-a ofụ ọgwụ mgbochi akpịrị ọ ,ụ, a kwesịrị belata usoro onunu ogwu ya rue 25mg kwa ụbọchị.

Maka ọgwụgwọ CHF dose mbụ kwa ụbọchị bụ 12.5 mg, were n’oge, yabụ, n’etiti izu ụka, a na-abawanye dose ahụ site ugboro abụọ (12.5, 25, 50 mg). Ulo mmezi bu 50 mg kwa ubochi. Iji mee ka mmetụta a na-ahụ anya bekee, a na-atụ aro ịkọ ya Presartan N (Losartan ya na onye na-ahụ maka antihypertensive).

Mmekorita

Iji ọgwụ ọgwụ eme ihe na ọgwụ ọgwụ nwere ọgwụ potassium nwere potassium na-eme ka ọnụọgụ) na-abawanye n'ihe ize ndụ nke mmepe hyperkalemia. Nchikota nke ị theụ ọgwụ ahụ na ihe eji egbu mmadụ nwere ike imebi mbelata EGO. Nkwonkwo nnabata nke Presartan na Ndị NSAID na-enyere aka belata mmetụta hypotensive nke ọgwụ ahụ. Site na nke imekotaotu aka nke ogwu ya na ọgwụ ndi ozo mmetụta hypotensive.

Mwepụta wepụtara ya na ihe mejupụtara

Presdị nke Presartan bụ mbadamba ihe eji eme fim: na usoro nke 25 na 50 mg - biconvex, pink, mbadamba 25 mg nke nwere akara nkewa n'otu akụkụ, na usoro onodu ogwu nke 100 mg - dobe-udi, biconvex, ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha 100 ”n'otu akụkụ na“ BL ”n'akụkụ nke ọzọ (PC 10. Na ntanetị ọnya, 3 ọnya na kaadiboodu, pcs 14. Na nchapu agba, ọnya abụọ na igbe kaadi).

Ngwakọta 1 mbadamba 25/50 mg:

• ihe na-arụ ọrụ: potassium losartan - 25/50 mg,
• ihe inyeaka: stachi akpọnwụ, microcrystalline cellulose, ọcha talc, colloidal silicon dioxide, sodium sitashi glycolate, magnesium stearate, mmanya mmanyaproprol, methylene chloride, opadry OY-55030, acha uhie uhie uhie.

Ngwakọta 1 mbadamba 100 mg:

• ihe na-arụ ọrụ: potassium losartan - 100 mg,
• ihe inyeaka: stachi ọka, microcrystalline cellulose, talc, colloidal silicon dioxide, sodium carboxymethyl stachi, magnesium stearate, hypromellose, titanium dioxide, talc, macrogol.

Mlọ ọgwụ

Presartan na-abanye ngwa ngwa site na eriri afọ (GIT). Metabolized site na izizi ya na imeju. Ogo nke ijikọ protein protein nke losartan na metabolites ya bụ 92-99%. Bioavailability - 33% (nri oriri enweghị mmetụta). Ọgwụ ọ bụla abanyeghị n’ihe mgbochi nke ụbụrụ. Ọ naghị agbakọ n'ime ahụ, a na-ebupụ excretion na mmamịrị na bile. Ndụ ọkara nke losartan bụ awa 2.

Ihe ngosi maka ojiji

• ọbara mgbali elu na ọbara mgbali ventricular (iji belata ihe ize ndụ nke ịmalite ọrịa obi na ọnwụ),
• ụdị II mellitus ọrịa shuga na proteinuria (iji belata ihe ize ndụ nke proteinuria na hypercreatininemia),
• A na - eji nkụchi obi na - adịghị ala ala dị ka akụkụ nke ọgwụgwọ njikọta mgbe enweghị ike iji angiotensin na - agbanwe ndị na - egbochi enzyme (ACE).

Ihe ngbanwe

• oke imeju ˃ 9 isi na -mụaka-Pugh (maka mbadamba 100 mg),
• ime na lactation,
• afọ ruo afọ 18
• mmụba nke ihe ndị metụtara Presartan.

Contraindications (maka 100 mg mbadamba):

• gout
• hyperuricemia
• mmeghachi omume nfụkasị ahụ n'oge ọgwụgwọ gara aga yana ndị na - egbochi ACE ma ọ bụ ọgwụ ndị ọzọ.
• ụkwara ume ọkụ,
• systemic ọbara ọrịa
• mbelata ọbara (BCC),
• hypotension akwara,
• ngalaba na ọgwụ ndị na - abụghị ọgwụ steroidal (NSAIDs),
• akwara obi
• nká.

Ntụziaka maka iji Presartan: usoro na usoro onunu ogwu

A na-anara mbadamba ihe ndị n’echere n’eche otu ugboro kwa ụbọchị n’agbanyeghi nri ị na-eri.

Egosiputa usoro ogwu:

• Ọbara ọgbụgba akwara: usoro a tụrụ aro ka ọ bụrụ 25 mg / ụbọchị, nkezi a na-agbaso 50 mg / ụbọchị, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ya ruo 100 mg / ụbọchị, ebe ị na-a theụ ọgwụ ahụ ugboro abụọ n'ụbọchị.
• nkụchi obi: a na-atụ aro mbido mbụ bụ 12.5 mg / ụbọchị, a na-ebunye titration dose na etiti izu. Onu ogugu doziri bu 50 mg / ubochi,
• igbochi ọrịa obi na ọrịa obi na ndị ọrịa nwere ọbara mgbali elu na ọbara mgbali aka ekpe: a na-atụ aro ọgwụ mbụ bụ 50 mg / ụbọchị, mgbe ahụ ọ ga-amụba ka ọ bụrụ 100 mg / ụbọchị, ma ọ bụ usoro nchịkọta hydrochlorothiazide ka edepụtara,
• ụdị II mellitus ọrịa shuga na proteinuria: usoro a ka akwadoro bụ 50 mg / ụbọchị, mgbe ahụ ọ mụbara na 100 mg / ụbọchị.

Otu ndị ọrịa pụrụ iche:

• imeju imeju (˂ 9 isi na Child-Pugh scale), na-a highụ ọgwụ mgbochi ọrịa, hemodialysis, afọ karịrị afọ 75: ọgwụ mbụ ị shouldụ ọgwụ agaghị agafe 25 mg / ụbọchị,
• Ọrụ imeju na-arụ ọrụ: a ga-eji obere ọgwụ ọ bụla.

Nsonaazụ

A na-anabatakarị Presartan na usoro onunu ogwu nke 25 na 50 mg. Mmeghachi omume n'akụkụ nwere ike ime n'ụdị afọ ọsịsa, dyspepsia, olu mgbu, ọzịza, isi ọwụwa, ọgbụgba, ọgba aghara ụra, hyperkalemia (ịta mmadụ ụta 5.5 meq / l), n'ọnọdụ ndị a na-adịghị ahụkebe, ụkwara, ọdịda okuku ume, tachycardia, angioedema ( egbugbere ọnụ, ihu, pharynx na / ma ọ bụ ire), urticaria, ụba ọrụ nke enzymes imeju, ọkwa serir bilirubin.

Nsonaazụ puru iche mgbe ị na-ewere mbadamba Presartan na usoro onodu ogwu nke 100 mg:

• sisitemu akwara: tachycardia, palpitations, imi, imirikiti orthostatic hypotension, arrhythmias, bradycardia, vasculitis, angina pectoris, infarction myocardial,
• usoro nri: afọ ọsịsa, mgbu afọ, ọgbụgbọ, dyspepsia, akọrọ mucosa, anorexia, vomiting, eze mgbu, afọ ntachi, gastritis, flatulence, ịba ọcha n'anya, ọrụ imeju na-arụ ọrụ,
• usoro akwara: azụ nke akwara azụ, azụ na mgbu mgbu, ogbu na nkwonkwo, ogbu na nkwonkwo, mgbu na ubu, ikpere, fibromyalgia,
• akpụkpọ ahụ: erythema, akpụkpọ akọrọ, ecchymosis, photoensitivity, alopecia, sweating mụbara,
• Ihe nfụkasị ahụ: nfụkasị anụ ahụ, itching, urticaria, angioedema (gụnyere edema nke larynx, ire),
• hematopoiesis: thrombocytopenia, eosinophilia, purpure nke Schoenlein - Genoch, ntakịrị mbelata na hemoglobin na hematocrit,
• sistemụ ụjọ: isi ọwụwa, ọgbụgbọ, ehighị ụra, nchekasị, ụra, ụra, nchekasị nchekasị, paresthesia, hyposthesia, neuropathy akụkụ, oke ụjọ, ataxia, ịda mba, tinnitus, nkụda mmụọ, ọgba aghara, migraine, conjunctivitis, visual visual visual,
• usoro iku ume: ụkwara, ọrịa ụkwara ume ọkụ, akwara ozi afọ, imi mkpọchi, sinusitis, oke akụkụ iku ume,
• sisitemu mkpụrụ ndụ: urinary tract na-efe efe, urination peremptory, ọrụ ezughi oke, mbelata libido, enweghi ike,
• ọzọ: asthenia, mgbu obi, ike ọgwụgwụ, oke akụkụ, oke iwe nke gout,
• paradaịs nke ụlọ nyocha: hyperuricemia, mmụba nke mkpokọta urea, nitrogen residual nitrogen na creatinine n'ọbara ọbara, mmụba na ọrụ hepatic transaminases (agafeghị oke), hyperbilirubinemia.

Ntụziaka pụrụ iche

Eeh, mgbe ị malitere ị Presụ Presartan, ịkwesịrị idozi akpịrị ịkpọ nkụ kpatara, dịka ọmụmaatụ, site na ị diụ ọgwụ na oke doses, ma ọ bụrụ na enweghị ike idozi BCC, ọgwụgwọ kwesịrị ịmalite site na iji ọgwụ dị ala.

Ọgwụ ndị na-emetụta RAAS (renin-angiotensin-aldosterone sistemụ) na-enwe ike ime ka mkpokọta urea dị n'ọbara na ọbara serinine na ndị ọrịa nwere akwara akwara ma ọ bụ stenosis nke otu akụrụ akwara.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Emebeghi ihe omumu puru iche banyere ihe oma Presartan n’eji anya nke inya ugbo ala na usoro ndi ozo di nkpa. Agbanyeghị, ekwesịrị ichebara echiche maka mmetụta ndị ọ ga-ekwe omume, dị ka ịda ụra na ọgbụgbọ, na-achọ ịkpachara anya mgbe ị na-eme ihe egwu nwere ike ime.

Mkparịta ụka ọgwụ ọjọọ

• potassium-spure diuretics, nkwado potassium: ihe egwu nke ịba hyperkalemia,
• diuretics: ihe ọghọm nke mbelata ọbara mgbali elu,
• beta-igbochi na ọmịiko: na-eme ka mmetụta ha dịkwuo mma,
• rifampicin, flucanazole: belata ịta nke metabolite nọ n'ọrụ nke losartan n'ọbara,
• lithium: mmụba n'ọbara ya na ọbara ga-ekwe omume,
• NSAIDs: a na-ebelata oke mmetụta nke ọgwụ ahụ,
• ọgwụ ndị ọzọ na - egbochi ọgwụ ọnụ: ha na - eme ka mmekọrịta ha na hypotensive nwekwuo ike.

Ihe analogues nke Prezartan bụ Brozaar, Blocktran, Vazotens, Zisakar, Kozaar, Lozap, Cardomin-Sanovel, Lozartan, Renikard, Lakea, Vero-Lozartan, Lorista.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

A na-eresị mbadamba ụrọ Presartan N, ọnụ agbanyeghị nri.

Oge mbido na mmezi bụ 1 mbadamba 12.5 mg + 50 mg 1 oge kwa ụbọchị. Mmetụta antihypertensive kachasị na-enweta n'ime izu atọ nke ọgwụgwọ. Iji nweta nsonaazụ akpọkwu akpọrọ, ọ ga-ekwe omume iwelie onodu ogwu a rue mbadamba abụọ n ’usoro nke ọgwụ 12.5 mg + 50 mg otu ugboro n’ụbọchị. Oke kachasị kwa ụbọchị bụ mbadamba abụọ nke Presartan N.

N'ime ndị ọrịa nwere oke ọbara na-agagharị agagharị (dịka ọmụmaatụ, mgbe ị na-a largeụ ọgwụ ọ ofụ largeụ buru ibu), ọgwụ a na-atụ aro ka losartan dị na ndị ọrịa nwere hypovolemia bụ 25 mg otu ugboro n'ụbọchị. N'akụkụ a, a ga-amalite ọgwụgwọ na Presartan N mgbe ọ kwụsịrị ọrịa diuretics na mgbazi nke hypovolemia.

N'ime ndị ọrịa agadi na ndị ọrịa nwere nsogbu gbasara obere akwara, gụnyere ndị nwere ọrịa diaal, ọ nweghị ndozi ọgwụ achọrọ ka achọrọ.

Mbelata ihe ize ndụ nke ọrịa obi na onwu na ndị ọrịa nwere ọbara mgbali elu na mgbali ventricular hypertrophy.

Initialkpụrụ izizi nke losartan bụ 50 mg 1 oge kwa ụbọchị. Ndị ọrịa na-enweghị ike imezu ebumnuche ọbara mgbe ha na-ewere losartan 50 mg / ụbọchị chọrọ ọgwụgwọ na ngwakọta nke losartan na obere mmiri hydrochlorothiazide (12.5 mg), ma ọ bụrụ na ọ dị mkpa, mụbaa dose nke losartan na 100 mg yana njikọ hydrochlorothiazide na uzo nke 12.5 mg / ụbọchị, n’ọdịnihu - mụbaa na mbadamba 2 nke ọgwụ na usoro nke 50 / 12.5 mg na ngụkọta (100 mg nke losartan na 25 mg nke hydrochlorothiazide kwa ụbọchị otu ugboro).

Omume ọgwụ

Presartan H nwere ngwakọta nke losartan na hydrochlorothiazide, ihe abụọ ahụ nwere mmetụta antihypertensive na-agbakwunye, na-ebelata ọbara mgbali elu (BP) karịa nke ọ bụla n'ime otu.

Losartan bụ onye antagonistin II receptor antagonist (subtype AT1) maka nchịkwa ọnụ. Losartan na ọgwụ ya na-arụ ọrụ na-arụ ọrụ (E 3174) na vitro na vivo na-egbochi mmetụta physiologio nke angiotensin II, n'agbanyeghị isi iyi ma ọ bụ ụzọ nke njikọta. Losartan na-ejikọ ọnụnọ nke AT1 na-ejikọ ma ọ bụ na-ejikọ ma ọ bụ na-egbochi ndị na-enweta homonụ na ion ndị ọzọ, nke na-arụ ọrụ dị mkpa na ntụgharị nke ọrụ nke sistem obi. Na mgbakwunye, losartan anaghị egbochi enzyme angiotensin na-agbanwe (ACE) - kininase II, na, yabụ, anaghị egbochi mbibi bradykinin, yabụ mmetụta ndị ọzọ na-akpaghị aka na bradykinin (dịka ọmụmaatụ, angioedema) dị ụkọ.

Mgbe ị na-eji losartan, enweghị mmetụta nke nzaghachi na-adịghị mma na zụlite renin na-eduga n'ịba ụba na ọrụ plasma renin. Mmụba nke ọrụ renin na-ebute mmụba nke angiotensin II na plasma ọbara. Agbanyeghị, ọrụ antihypertensive na mbelata nke ịhapụ aldosterone na plasma ọbara na-adịgide, nke na-egosi mmachi dị mma nke ndị na-anabata angiotensin II. Losartan na metabolite na-arụ ọrụ ya nwere mmekọrịta dị ukwuu maka ndị na-anabata angiotensin M karịa ndị na-anabata angiotensin P. Ihe na-arụ ọrụ metabolite dị 10-40 ugboro karịa ka losartan.

Mgbe otu mkpụrụedemede ọnụ gasịrị, mmetụta antihypertensive (mbelata systolic na ọbara mgbali ọbara) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24. Mmetụta antihypertensive kachasị na-etolite izu 3-6 mgbe mmalite ọgwụ.

Hydrochlorothiazide - turezide diuretic, na-akpaghasị nlọghachi nke sodium, chlorine, potassium, maịlị magnesium na nephron distal, na-egbu oge mkpụrụ nke calcium, uric acid. Mmụba na mkpịsịwa akụrụngwa ndị nke ndị a bụ ihe mmụba na mmụba (n'ihi osmotic nke mmiri). Na -ebelata olu plasma ọbara, na-eme ka plasma renin ọzọ na sistemụ aldosterone. Mgbe etinyere ya na oke ọnụọgụ, hydrochlorothiazide na-abawanye mmiri nke bicarbonates, ebe iji ogologo oge na-ebelata mwepụta nke calcium.

Mmetụta antihypertensive na-etolite n'ihi mbelata olu nke ọbara na-ekesa (BCC), mgbanwe na nrụghachi nke mgbidi vaskụla, ibelata mmetụta nke vasoconstrictor amines (adrenaline, norepinephrine) na mmụba nke mmetụta na-akụda mmụọ na ganglia. Ọ naghị emetụta ọbara mgbali nkịtị. A na-ahụ mmetụta ahụ a na - enwe nchara ahụ ka awa 1-2 gachara, rute ihe kachasị mgbe awa anọ gachara, ọ ga - anọdụ 6 awa. Mmetụta antihypertensive na-apụta na ụbọchị 3-4, mana ọ dị izu 3-4 iji nweta nsonaazụ ọgwụgwọ kachasị mma.

Ajuju, azịza, nyocha banyere ọgwụ Presartan N

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Mpempe mwepụta, nkwakọ ngwaahịa na ihe mejupụtara Presartan N

Mbadamba nkume ndị ahụ, odo na-acha odo odo, bụ biconvex oval, n'akụkụ nke obe: isi ahụ bụ site na-acha ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

Ndị pụrụ iche: lactose monohydrate 111.50 mg, microcrystalline cellulose 58 mg, pregelatinized stachi 3 mg, ọka ọka 12 mg, colloidal silicon dioxide 1 mg, magnesium stearate 2 mg.

Ihe mejupụtara Shell:
hypromellose 2.441 g, titanium dioxide 0.60 mg, talc 1.50 mg, macrogol-6000 0.40 mg, quinoline acha odo odo 0.058 mg.

14 pi. - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu.

Usoro onunu ogwu na nhazi

Site na mgbali ọbara, akwara ụbọchị mbụ bụ 25 mg, nkezi ụbọchị kwa ụbọchị bụ mg 50, ugboro nchịkwa bụ 1 oge / ụbọchị.

Mmetụta hypotensive kachasị na-etolite izu 3-6 mgbe mmalite ọgwụ. Ọ bụrụ na ọ dị mkpa, enwere ike ịba ụba nke ọgwụ a gaa na 1 00 mg kwa ụbọchị. N'okwu a, ọ ga-ekwe omume ị theụ ọgwụ ahụ ugboro abụọ n'ụbọchị.

Ọgwụ nke mbụ maka ndị ọrịa nwere nkụchi obi bụ 12.5 mg 1 oge / ụbọchị. Nke a, a na-enye ọgwụ ahụ ụzọ oge ezumike kwa izu (i.e. 12.5 mg / ụbọchị, 25 mg / ụbọchị. 50 mg / ụbọchị) na oge mmezi nke 50 mg 1 oge / ụbọchị, dabere na ndidi onye ọgwụ a.

Mgbe ị na-edepụta ọgwụ ahụ maka ndị ọrịa na-anata oke ọgwụ diuretics, ekwesịrị ịbelata ọgwụ nke mbụ na 25 mg 1 oge / ụbọchị.

Ekwesịrị inye ndị ọrịa nwere nsogbu imeju nwere obere ọgwụ losartan,

N'ime ndị ọrịa agadi, yana ndị ọrịa nwere nsogbu gbasara akụrụ, tinyere ndị ọrịa n'ọrịa ha, ọ nweghị mkpa ịhazigharị usoro ọgwụ mbụ.

Enwere ike ịkọwa Presartan na njikọ ọgwụ ndị ọzọ na - alụ ọgụ. Enwere ike iji Losartan n'agbanyeghị nri nri.

Mmetụta akụkụ

A na-anabatakarị Presartan. Enwere ike ịhụ ya: afọ ọsịsa, dyspepsia, mgbu akwara, ọzịza, ọgbụgbọ, ọgba aghara ụra, isi ọwụwa, hyperkalemia (potassium n'ime ọbara karịa 5.5 meq / l). N'ọnọdụ ndị a na-adịghị ahụkebe, enwere ike ịnwe ụkwara, iku ume iku ume, tachycardia, angioedema (nke gụnyere ihu nke egbugbere ọnụ, egbugbere ọnụ, pharynx na / ma ọ bụ ire), urticaria, ụba ọrụ nke transminates “imeju”, bilirubin na ọbara.

Njirimara ngwa

N'ime ndị ọrịa nwere akpịrị ịkpọ nkụ (dịka ọmụmaatụ, ịnata ọgwụgwọ na ọnụọgụ dị elu), hypotension hypotension nwere ike ịmalite na mmalite ọgwụgwọ na Presartan. Ọ dị mkpa iji dozie akpịrị ịkpọ nkụ tupu ị mebelata ma ọ bụ ịmalite ọgwụgwọ na obere ala.

Ihe omuma nke ogwu na-egosi na itinye uche nke losartan na plasma na ọkwa nke ndị ọrịa nwere ọrịa cirrhosis na-abawanye ụba, yabụ, ndị ọrịa nwere akụkọ ọrịa ọrịa imeju kwesịrị ịkọwa ọgwụ dị ala.

Drugsfọdụ ọgwụ ọjọọ na-emetụta usoro kipinapgiotensin nwere ike ịbawanye urea ọbara na serum creatinine na ndị ọrịa nwere ọrụ mkpo ya.

Amabeghị ma losartan dị mmiri ara. Mgbe etinyere ọgwụ akara n'oge a na-enye nwa ara, o kwesịrị ime mkpebi ikwusi ị breastụ ara ma ọ bụ ịkwụsị ọgwụgwọ.