Mpempe ọgwụ Ciprofloxacin: ntuziaka maka ojiji

Na ophthalmology: ọrịa anya na-efe efe na ọnya ọrịa (nnukwu na subacute conjunctivitis, blepharitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, ọnya nje na-adịghị ala ala, dacryocystitis, meibomitis (bali), ọnya na-efe efe nke anya mgbe trauma ma ọ bụ inoperative) ọrịa na-efe efe na ịwa ahụ ophthalmic.

Na otorhinolaryngology: otitis externa, ọgwụgwọ nke nsogbu ọrịa postolowo.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'obodo. Maka oria dị nwayọ ma na-adị obere oge, a na-etinye 1-2 mmerụ ahụ n'ime mkpokọta njikọ nke anya emetụtara kwa awa anọ, na maka ọrịa siri ike, 2 na-agbadata kwa awa. Mgbe ọ rụchara ọrụ, a na-ebelata dose na ugboro ole nrụnye.

N'ihe banyere ọnya ọnya afọ: 1 okpu ọ bụla 15 nkeji 6 awa, mgbe ahụ, okpu 1 kwa minit 30 ọ bụla n'oge awa, na ụbọchị 2 - 1 okpu kwa elekere n'oge awa, site na 3 ruo ụbọchị 14 - 1 okpu ọ bụla 4 awa mgbe awa. Ọ bụrụ na mgbe ụbọchị 14 nke epithelization ọgwụgwọ emebeghị, enwere ike ịga n'ihu ọgwụgwọ.

A na-edokwasị ude na-emegharị n'azụ nkuchianya nke anya emetụta emetụta.

Omume ọgwụ

Onye na-ahụ maka ọgwụ nje na - ekesa mmiri, nke na - achọpụta fluoroquinolone, na - egbochi nje gyrase (topoisomerases II na IV, na - ahụ maka usoro nke ịchịkwa DNA chromosomal gburugburu nuklia RNA, nke dị mkpa maka ịgụ mkpụrụ ndụ ihe), na - akpaghasị njikọ DNA, uto nje na nkewa, na - akpata morphological mgbanwe (gụnyere mgbidi sel na membranes) na ọnwụ ngwa ngwa nke mkpụrụ ndụ nje.

Ọ na - eme nje bacteria na - egbu ihe n'ahụ gram n'oge ezumike na nkewa (ebe ọ na - emetụta ọ bụghị naanị DNA gyrase, kamakwa ọ na - akpata lysis nke cell cell), na microorganisms gram-positive naanị naanị n'oge nkewa.

A na-akọwara ntakịrị mmerụ ahụ maka mkpụrụ ndụ macroorganism site na enweghị DNA gyrase n'ime ha. Mgbe ị na-a ciụ ọgwụ ciprofloxacin, enweghi mmepe nke ya na iguzogide ihe ndị ọzọ na - eme ọgwụ nje nke na - esiteghị na otu nke ndị na - egbochi mkpụkọ, nke na - eme ka ọ bụrụ nke ukwuu megide nje ndị na - eguzogide, dịka ọmụmaatụ, na aminoglycosides, penicillins, cephalosporins, tetracyclines na ọtụtụ ọgwụ nje ndị ọzọ.

Nje bacteria dị ka Gram-negative aerobic nwere ike ibuso ciprofloxacin: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescensippa r. , Morganella morganii, Vibrio spp., Yersinia spp.), Nje ndị ọzọ na-egbu gram (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campyunlobacterium). Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium ụkwara nta, Mycobacterium kansasii, Corynebacterium diphtheriae,

Ọrịa nje aerobic dị mma: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).

Imirikiti methicillin na-eguzogide staphylococci na-eguzogide ọgwụ na ciprofloxacin. Mmetụta uche nke prọonia, kọọrọ nke Enterococcus faecalis, Mycobacterium avium (nke dị n'ime intracellularly) na-agafe agafe.

Na-eguzogide ọgwụ: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Enweghi nsogbu megide treponema pallidum.

Nguzogide na-etolite nwayọ nwayọ, n'ihi na, n'otu aka ahụ, mgbe ọrụ nke ciprofloxacin enweghị ihe microorganisms na-adịgide, n'aka nke ọzọ, mkpụrụ ndụ nje enweghị enzyme na-egbochi ya.

Nsonaazụ

Mmeghachi omume nfụkasị ahụ, itching, ọkụ, ọnya dị nro na hyperemia nke conjunctiva ma ọ bụ membrane tympanic, ọgbụgbọ, ọ na-adịkarịghị - ọzịza nke nku anya, fotophobia, lacrimation, mmetụ nke ndị mba ọzọ na anya, ihe na-adịghị mma na-ekwu okwu n'ọnụ n'ọnụ ozugbo instillation, belata visual acuity, anya. na-eme ka ndị ọrịa nwee ọnya afọ, keratitis, keratopathy, ọdịdị nke ntụpọ ma ọ bụ ọgbụgba corneal, mmepe nke superinfection.

Mlọ ọgwụ

Ciprofloxacin na-egbochi mkpụrụ ndụ DNA, nke na-egbochi ọrụ topoisomerases na-eme ka mkpụrụ ndụ DNA ghara ịdị. Ọgwụ na-egbochi iyingomi mkpụrụ ndụ ihe nketa nke nje, na-egbochi uto na ịmụmụ nke microorganisms. Ọ nwere nje nke na-akpata nje na micromgangang gram na-adịghị mma na ọnọdụ dị egwu ma na-arụ ọrụ. A na-ekpughe nje ndị nwere ihe na-acha ọbara ọbara na mgbochi oge naanị n'oge nkewa. Nnọọ mmetụta na ciprofloxacin:

• Gram-ọjọọ aerobic microorganisms (Escherichia, Salmonella, Shigella, Citrobacter, Klebsiella, Enterobacter, Proteus, Cholera Vibrio, Serrations),
• microorganisms ndị ọzọ na-adịghị mma (pseudomonads, moraxella, aeromonads, pasteurella, campylobacter, gonococcus, meningococcus),
• nje intracellular paraisites (legionella, brucella, chlamydia, listeria, tubercle bacillus, diphtheria bacillus),
• gram-aerobic microorganisms (staphylococci, streptococcus).

Omimi mgbanwe di iche-iche nwere:

Ọgwụ anaghị emetụta:

• ureaplasma urealitikum,
• methicillin na-eguzogide staphylococci,
• clostridia
• nocardia
• treponema pale.

Nkwado na-amalite nwayọ. Mgbe ojiji nke ciprofloxacin, nje ndị na-adịgide adịgide adịghị adịgide. Na mgbakwunye, nje ọrịa anaghị emepụta enzymes nke na-ebibi ọgwụ nje.

Mlọ ọgwụ

Mgbe ejiri ya n’ime mpaghara, a na-abanye ntakịrị ọgwụ iji banye n’ọbara. Ciprofloxacin na-agbakọ na anụ ahụ metụtara, na-arụ ọrụ mpaghara. A na-achọta ọgwụ mgbochi ọgwụ 60-90 nkeji mgbe nchịkwa mmanụ ahụ.

Ngwa na usoro onunu ogwu

A na-ahụta ude 1-2.5 cm n'elu nkuchianaya 3 ugboro n'ụbọchị. A na-agwọ ha maka ụbọchị 2, mgbe nke a gasịkwara ọnụ ọgụgụ nke usoro iji ruo 2 kwa ụbọchị. N'ihe dị oke njọ nke ọrịa na-efe efe, a na-eji mmanu mmanụ 3 awa ọ bụla. A na-ebelata ọtụtụ usoro dị ka ihe ịrịba ama nke oke mbufụt na-apụ n'anya. Ọgwụgwọ ahụ agaghị adị ihe karịrị ụbọchị iri na anọ. Tupu iwebata ude ahụ, a na-edobe nkuchi anya. A na-ete mmanụ ahụ nwayọ nwayọ site na tube wee webata ya na sachie njikọta. A na-ewepụta eyelids ma na - agbatị ya na nkuchi anya nke 60-120 sekọnd. Mgbe nke a gasịrị, onye ọrịa ahụ kwesịrị ịra kpuchie anya ya maka nkeji 2-3.

Contraindications maka iji mmanu mmanu dinprofloxacin

Enwere ike iji mmanu mmanu eji:

• mmadụ ịghara ịnabata ihe ndị na-arụ ọrụ na ihe inyeaka
• malitere ịrịa conjunctivitis,
• fungal ọrịa na nke anya.

Ndepụta nke contraindications gụnyere:

• akpọpụtara ọnya anụ arụ,
• nnukwu ọrịa ụbụrụ,
• nwekwuru ihe nkwaghari.

Dodoụbiga ya ókè

Mgbe ị na-eji mmanụ tee mmanụ maka ebumnuche ya, ịdoụbiga mmanya ókè agaghị enwe ike. Ọ bụrụ na ọgwụ ahụ na-abanye n’afọ na-abanye na afọ, ọgbụgbọ, ube tọgbọ, isi ọwụwa, iche echiche, na ọnọdụ nkụda mmụọ na-eme. Ihe enyemaka mbu gụnyere iweghachi nguzozi-nnu nke ahụ, ịbawanye acidity nke mmamịrị, nke na-egbochi imepụta okwute n’ime akụrụ na eriri afọ.

Mkparịta ụka ọgwụ ọjọọ

Iji mmanu mmanu buru ibu nwere ike inye aka mee ka mkpokoro ogwu na-aga n'ihu na-eme ka ọbara kwụsịlata, na-ebelata ihe na-egbochi caffeine ma na-eme ka mmetụta anticoagulants kwụsị. Ojiji nke ciprofloxacin na cyclosporine nwere ike ibute mmụba nwa oge na ntinye nke creatinine n'ime ọbara.

Ọgwụ ndị a nwere mmetụta yiri ya:

• Saịprọs
• Tsiprolet,
• Oftocipro,
• Ciprofloxacin (tụlee),
• Ciprofloxacin (mbadamba ihe mkpuchi fim).

Ngwá ọgwụ ọgwụ:

Mlọ ọgwụ

Antimicrobial gị n'ụlọnga nke ụdịdị dị iche iche nke ìgwè nke fluoroquinolones. Ọ nwere mmetụta nje na-akpata. Na-egbochi DNA imechi ma na-egbochi ịkpa ike nje DNA.

Arụ ọrụ nke ukwuu megide ọtụtụ nje gram-na-adịghị mma: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.

Na-arụsi ọrụ ike megide Staphylococcus spp. (gụnyere ụdọ na-emepụta ma na-anaghị emepụta penicillinase, ụdị methicillin na-egbochi), ụfọdụ ụdị Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.

Ciprofloxacin na-arụ ọrụ megide nje ndị na-emepụta beta-lactamases.

Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides na-eguzogide ọgwụ na ciprofloxacin. Aghọtaghị ihe ọ bụla megide Treponema pallidum.

Mlọ ọgwụ

Anọrọ ngwa ngwa si na nri diges. Usoro ndu a na-ebugharị site na nchịkwa ọnụ bụ 70%. Iri nri na - emetụta nnabata nke ciprofloxacin. Indmịnye protein ndị dị na plasma bụ 20-40%. A na-ekesa ya na akwara na ahụ. Ọ banye n’ime mmiri mkpụrụ mmiri nke cerebrospinal: nchịkọta nke ciprofloxacin ya na meninges na - enweghị mmerụ ahụ ruru 10%, ndị nwere mmamiri - ruru 37%. A na-enweta oke omimi na bile. Ara na mmamịrị na bile.

Usoro usoro onunu ogwu

Onye ọ bụla. N'ime - 250-750 mg ugboro abụọ / ụbọchị. Oge ọ ga-eji ọgwụgwọ sitere na ụbọchị 7-10 ruo izu anọ.

Maka nchịkwa intravenous, otu ọgwụ bụ 200-400 mg, ugboro ole nchịkwa bụ oge 2 / ụbọchị, oge ọgwụgwọ ga-abụ izu 1-2, ma ọ bụrụ na ọ dị mkpa karịa. Ọ ga - ekwe omume ịhazi iv n'ime ụgbọelu, mana ọkacha mma, nchịkwa ụmụ ntakịrị maka nkeji iri atọ.

Mgbe etinyere ya n’elu, a na-etinye 1-2 mmerụ ahụ n’ime obere njikọ mkpị anya nke anya emetụtara ọ bụla awa iri na anọ ọ bụla.

Oke kachasị kwa ụbọchị maka ndị okenye, mgbe ejiri ọnụ kwuo ya bụ 1.5 g.

Mmetụta:

Site na nri digestive: ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, mgbu nke afọ, ọrụ ịba ụba nke transmeta ịba ọcha n'anya, alkaline phosphatase, LDH, bilirubin, pseudomembranous colitis.

Site n'akụkụ nke usoro ụjọ ahụ: isi ọwụwa, nkụda mmụọ, inwe nkụda mmụọ, nsogbu ịrahụ ụra, ụra abalị, ịtụgharị uche, mgbakasị ahụ.

Site na urinary system: kristalia, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, mmụba dị mkpụmkpụ nke serum creatinine.

Site na sistemụ hemopoietic: eosinophilia, leukopenia, neutropenia, mgbanwe mgbanwe platelet.

Site na akụkụ nke usoro akwara obi: tachycardia, obi ọgba aghara, akwara ozi.

Mmeghachi omume nfụkasị ahụ: pruritus, urticaria, ụbụrụ Quincke, ọrịa Stevens-Johnson, ọrịa ogbu na nkwonkwo.

Mmeghachi omume ojoo jikọtara ya na usoro chemotherapeutic: kandụl.

Mmeghachi omume mpaghara: ọnya, phlebitis (ya na nchịkwa iv). Site n'iji anya anya, mgbe ụfọdụ enwere ike ịdị nro na hyperemia.

Kedu ụdị ude

Nkọwapụta banyere ọgwụ a na-ekwu na ọ bụ nke otu fluoroquinolones. Ihe ndi otu a n’enye aka n’oru mgba megide oria ojoo nke negosiputa ha.

Omume a dị na ọkwa mpaghara, naanị ụdị mbadamba ụdọ ntọhapụ ka arụ ọrụ nke ọma.

Mmetụta ọgwụgwọ ahụ na-apụta mgbe obere oge. Usoro ọgwụgwọ agaghị akpata ọnụọgụgụ nke mmetụta.

Mmanụ otite nke Ciprofloxacin na-enyere aka wepu ngwa ngwa ọrịa ahụ ngwa ngwa.

Ọrụ umi na mejupụtara

Nime aru ike aru ike bara aru bu ihe akporo ciprofloxacin.

Ejiri ya na usoro ọgwụgwọ ahụ ogologo oge ma jisie ike gosipụta onwe ya dịka ezigbo ngwaọrụ.

Ọ na - emetụta ụmụ irighiri ihe DNA nke nje ahụ, na - egbochi ọganiru na ọrụ ịmụpụta ihe, nke na - eduga n'ọnwụ n'enweghi ike nlọghachi ọrịa ahụ.

N'oge nyocha ahụike, achọpụtara na n'ihe metụtara ụfọdụ ụdị, ọrụ ahụ bụ efu. Nke ahụ bụ, n'ọnọdụ dị otú ahụ, ọ dị mkpa iji ọgwụ analogues nke ciprofloxacin anya ọdịda.

Ngwakọta ahụ gụnyere ihe ndị dị ka:

• hydrochloric acid (diluted),
• paraffin mmiri
• mmiri dị ọcha
• Trilon B
• ciprofloxacin.

Ọtụtụ n’ime ha anaghị emetụta arụ ọrụ nke anụ ahụ.

Na ọnụnọ nke ekweghị ekwe, elegharala ndị ahụ achọpụtala na oke iwe. Nke a nwere ike ibute mmebi ahụike na-achọghị.

Womenmụ nwanyị dị ime na onye na-enye nwa ara

N'oge ime na lactation na contraindicated. O nweghi ihe aka ma ọ bụrụgodị na uru nne dị ya karịrị ihe ọjọọ nwa ebu n’afọ.

N'ime ụmụaka na-erubeghị afọ 18, a machibidoro iji iwu eme ihe.

Mmekọrịta na ọgwụ ndị ọzọ:

Site n'iji ciprofloxacin na didanosine mee ihe, a na-ebelata nnabata nke ciprofloxacin n'ihi ihiwe ciprofloxacin na aluminom na magnesium buffers na didanosine.

N'iji oge agha na-emekọ oge, ohere nke ọbara na-abawanye.

N'iji oge nke ciprofloxacin na theophylline, mmụba nke ịhapụ theophylline na plasma ọbara, mmụba na T, ga-ekwe omume_1/2 theophylline, nke na-eduga n'ịbawanye n'ihe ize ndụ nke ịmalite mmetụta na-egbu egbu nke metụtara theophylline.

Nlekọta nke ọgwụ mgbochi otu oge, yana nkwadebe nwere alumini, zinc, iron ma ọ bụ magnesium, nwere ike ime ka mbelata ciprofloxacin, yabụ na etiti dị na nhọpụta ọgwụ ndị a kwesịrị opekata mpe awa anọ.

Ntụziaka pụrụ iche na ịkpachapụ anya:

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa nsogbu, achọrọ mgbazi usoro onunu ogwu. A na-eji nlezianya mee ihe na ndị ọrịa agadi, yana ọrịa arteriosclerosis, ihe mberede ụbụrụ, ọgbụgbọ, ọrịa nkwarụ nke etiology na-edoghị anya.

N'oge ọgwụgwọ, ndị ọrịa kwesịrị ịnata ọnya mmiri zuru oke.

N'ọnọdụ nke afọ ọsịsa, a ga-akwụsị ciprofloxacin.

Site na nchịkwa ivuraị nke ciprofloxacin na barbiturates, njikwa ọnụego obi, ọbara mgbali, ECG dị mkpa. N'oge ọgwụgwọ, ọ dị mkpa ijikwa mkpokọta urea, creatinine, na usoro ịba ọcha n'anya na ọbara.

N'oge usoro ọgwụgwọ, enwere ike ịgbatị ahụ (karịchaa mgbe ị alcoholụ mmanya n'otu oge).

Anabataghị iwebata ọgwụ nke subprojunloival ciprofloxacin ma ọ bụ banye n'ime ihu anya.

Na arụ ọrụ ezumike ọrụ

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa nsogbu, achọrọ mgbazi usoro onunu ogwu.

Jiri na agadi

Jiri nlezianya mee ihe na ndị ọrịa agadi.

Jiri na nwata

Ndi nne na nna na umuaka na erubeghị afọ iri na ise.

Ngosiputa ogwu

Ọrịa na-efe efe na mkpali kpatara microorganisms nwere mmetụta nke ciprofloxacin, gụnyere ọrịa nke akụkụ okuku ume na akwara, akwara afọ na akụkụ ahụ aka ya, ọkpụkpụ, nkwonkwo, anụ ahụ, septicemia, ọrịa siri ike nke akụkụ ENT. Ọgwụ nke ọrịa postoperative. Mgbochi na ọgwụgwọ nke ibute ọrịa na ndị ọrịa nwere obere mgbochi.

Maka ọgwụ eji eme ihe: nnukwu na subacute conjunctivitis, blepharoconjunctivitis, blepharitis, ọnya nje, keratitis, keratoconjunctivitis, na-adịghị ala ikpe dacryocystitis, meibomites. Ọrịa ọnya na-efe efe mgbe mmerụ ahụ ma ọ bụ ahụ ndị si mba ọzọ. Propolaxis nke ana - ahụ anya n’egwuregwu ophthalmic.

Usoro usoro onunu ogwu

Onye ọ bụla. N'ime - 250-750 mg ugboro abụọ / ụbọchị. Oge ọ ga-eji ọgwụgwọ sitere na ụbọchị 7-10 ruo izu anọ.

Maka nchịkwa intravenous, otu ọgwụ bụ 200-400 mg, ugboro ole nchịkwa bụ oge 2 / ụbọchị, oge ọgwụgwọ ga-abụ izu 1-2, ma ọ bụrụ na ọ dị mkpa karịa. Ọ ga - ekwe omume ịhazi iv n'ime ụgbọelu, mana ọkacha mma, nchịkwa ụmụ ntakịrị maka nkeji iri atọ.

Mgbe etinyere ya n’elu, a na-etinye 1-2 mmerụ ahụ n’ime obere njikọ mkpị anya nke anya emetụtara ọ bụla awa iri na anọ ọ bụla.

Oke kachasị maka ndị okenye kwa ụbọchị mgbe ejiri ọnụ mee ya bụ 1.5 g.