Actovegin® (Actovegin®)

mbadamba mkpuchi.

Mbadamba ụrọ gbara agba nwere
Kernel: ike ọrụ: ihe ndị mejupụtara ọbara: hapaterivative nke ọbara nwa ehi - 200.0 mg n'ụdị Actovegin ® inye ikike * - 345.0 mg, ndị na-ebu ụzọ: stenesia magnesium - 2.0 mg, talc - 3.0 mg,
Shell: acacia gum - 6.8 mg, glycol wax - oke 0.1 mg, hypromellose phthalate - 29.45 mg, diethyl phthalate - 11.8 mg, mmiri mmiri nke quinoline edo alumonia - 2.0 mg, macrogol-6000 - 2 , 95 mg, povidone-K 30 - 1.54 mg, sucrose -52.3 mg, talc - 42.2 mg, titanium dioxide - 0.86 mg.
* Actovegin ® granrey nwere: ihe na - arụ ọrụ: ihe ndị mejupụtara ọbara: hemoderivative nke hemoderivative nke ọbara nwa ehi - 200.0 mg, ndị nwere ibu: povidone-K 90 - 10.0 mg, microcrystalline cellulose - 135.0 mg.

mbadamba biconvex gbara okirikiri, nke a na-ete na shei nke akwụkwọ ndụ akwụkwọ ndụ na-acha odo odo.

Omume ọgwụ

Mlọ ọgwụ
Actovegin ® bụ antihypoxant nke nwere ụdị mmetụta atọ: metabolic, neuroprotective na microcirculatory. Actovegin ® na-abawanye nnabata na ojiji nke oxygen, nke bụ akụkụ nke inositol phospho-oligosaccharides, na-emetụta ọfụma na ojiji nke glucose, nke na-eduga n'ịbawanye uru nke ike sel na mbelata nguzobe nke lactate n’okpuru ọnọdụ ọjọọ.

A na-atụle ọtụtụ ụzọ iji mejuputa usoro neuroprotective nke ị theụ ọgwụ ahụ.

Actovegin ® na-egbochi mmepe nke apoptosis sitere na amyloid beta peptide (AP25-35).

Actovegin mejuputara ọrụ nke ihe kappa B (NF-kB) nke nuklia, nke na-arụ ọrụ dị mkpa na nhazi nke apoptosis na mbufụt na sistemụ akwara na akụkụ ụjọ.

Usoro ozo eji eme ihe bu ihe anakpo ya na enzyme poly (ADP-ribose) -polymerase (PARP). PARP na-arụ ọrụ dị mkpa na nchọta na ịrụzi mbibi nke DNA alụbeghị ọgụ, na-agbanyeghị, ịgbalite oke enzyme nwere ike ịkpalite usoro ọnwụ nke mkpụrụ ndụ na ọrịa dịka ọrịa ụbụrụ na polyneuropathy mamịrị. Actovegin ® na-egbochi ọrụ PARP, nke na-eduga n'ịrụ ọrụ na arụ ọrụ nke steeti nke etiti na akụkụ ụjọ akwara.

Mmetụta dị mma nke Actovegin ® na-emetụta microcirculation na endothelium bụ mmụba nke nnuku ọbara na-agba ọsọ, mbelata mpaghara pericapillary, mbelata ụda myogenic nke precapillary arterioles na okpu sphincters, mbelata ogo arteriovenular shunt ọbara na-aga na oke ọbara ọbara na-arụ ọrụ na nnweta ọbara n'ọkwa na nnweta ọbara na ọnụ nitric oxide, na-emetụta microvasculature.

N'ime usoro ọmụmụ dị iche iche, achọpụtara na nsonaazụ ọgwụ Actovegin ® pụtara erughị nkeji iri atọ mgbe nchịkwa ya gasịrị. A na - ahụkarị mmetụta kachasị 3 awa mgbe parenteral na 2-6 awa gachara nchịkwa ọnụ.

Mlọ ọgwụ
N'iji usoro pharmacokinetic, ọ gaghị ekwe omume ịmụ ọgwụ ọgwụ Actovegin since, ebe ọ bụ naanị ihe mejupụtara anụ ahụ bụ nke na-adịkarị n'ahụ.

Dika akụkụ nke usoro ọgwụgwọ mgbagwoju anya:

• Ọrịa Sympiomatic nke nrụrụaka, gụnyere nrụrụ ụbụrụ na ọgbụgba.
• Ọrịa Symptomatic nke nsogbu mgbasa oke yana nsogbu ha.
• Ọrịa Symptomatic nke ọrịa mamịrị polyneuropathy na-arịa ọrịa mamịrị (DPN).

Ihe onyonyo 3D

Usoro onunu ogwu na nhazi

M / O, M / O (gụnyere n'ụdị nke infusion), n'ime / m.

Na njikọta maka mmepe nke mmeghachi omume anaphylactic, a na-atụ aro ka ọ nwalee maka ọnụnọ nke hypersensitivity na ọgwụ ahụ tupu mmalite nke infusion.

Ọrịa ụbụrụ na akwara nke ụbụrụ. 5-25 ml (200-1000 mg nke ọgwụ ahụ) kwa ụbọchị m / v kwa ụbọchị maka izu abụọ, na-esote ntụgharị gaa n'ụdị mbadamba.

Ọkpụkpụ ọrịa Ischemic. 20-50 ml (800-2000 mg nke ọgwụ) na 200-300 ml nke 0.9% sodium chloride ngwọta ma ọ bụ 5% iv dextrose solution dropwise 1 izu, mgbe ahụ 10-20 ml (400-800 mg nke ọgwụ) ) iv drip - izu 2 na udiri ngbanwe na udiri mbadamba.

Ọrịa vaskụla na akwara (ọnya na ọnyá) na nsonazụ ha. 20-30 ml (800–1200 mg nke ọgwụ ahụ) na 200 ml nke 0.9% slorum chloride solution ma ọ bụ 5% intravenous ma ọ bụ ihe mgbochi introvenous dextrose kwa ụbọchị maka izu anọ.

Polyneuropathy na-arịa ọrịa mamịrị. 50 ml (2000 mg nke ọgwụ) kwa ụbọchị intravenously maka izu 3 na-esochi mgbanwe n'ụdị mbadamba - mbadamba 2-3. 3 ugboro n'ụbọchị n'ihi na ọ dịkarịa ala 4-5 ọnwa.

Ọrịa ọnya. 10 ml (400 mg nke ọgwụ) iv ma ọ bụ 5 ml IM kwa ụbọchị ma ọ bụ ugboro 3-4 kwa izu, dabere na usoro ọgwụgwọ. Ikekwe, ejikọtara ya na ụdị usoro ọgwụgwọ Actovegin ® maka iji mpụga.

Mgbochi na ọgwụgwọ nke mmerụ ahụ nke anụahụ na akpụkpọ anụ mucous n'oge ọgwụgwọ radieshon. Nkezi bụ 5 ml (200 mg) iv kwa ụbọchị n’oge ezumike nke ikpughe radieshon.

Rystation cystitis. Transurethrally, kwa ụbọchị, ọgwụ mgbochi mmiri 10 ml (400 mg) yana ọgwụ nje. Ọnụego nchịkwa dị ihe dị ka 2 ml / min.

Ogologo oge ọgwụgwọ a na-ekpebi n'otu n'otu dabere na mgbaàmà na ogo nke ọrịa ahụ.

Ntụziaka maka iji ampoules nwere ebe ezumike

1. Debe ọnụ ọnụ ampoule ahụ jiri ntụpọ rịa elu.

2. Jiri mkpịsị aka na -eme mkpịsị aka ma na - eme ka ampoule dị, kwe ka mmiri ga - agbada site n'ọnụ ọnụ ampoule ahụ.

3. Biputu n'ọnụ ampoule ahụ n'ebe ihe adịghị mma site na ịhapụ gị.

Mpempe mwepụta

Injection, 40 mg / ml.

N'ihe banyere nrụpụta na nkwakọ ngwaahịa na Takeda Austria GmbH, Austria:

2, 5, 10 ml nke ọgwụ ahụ na ampoules iko na-enweghị agba na oge ezumike. 5 amp ọ bụla. na ngwungwu akpa agba. 1, 2 ma ọ bụ 5 paịlị na ngwugwu kaadiboodu. Mpempe akwụkwọ nchebe gburugburu nwere ihe ndebiri holographic na njikwa izizi na-agbakwunye na mkpọ ahụ.

N'ihe banyere imepụta na / ma ọ bụ nkwakọ ngwaahịa na LLC Takeda Pharmaceuticals, Russia:

2, 5, 10 ml nke ọgwụ ahụ na ampoules iko na-enweghị agba na oge ezumike. 5 amp ọ bụla. na mpempe plastik panister nke eji eme ihe nkiri ma ọ bụ ihe nkiri PVC. 1, 2 ma ọ bụ 5 paịlị na ngwugwu kaadiboodu. Mpempe akwụkwọ nchebe gburugburu nwere ihe ndebiri holographic na njikwa izizi na-agbakwunye na mkpọ ahụ.

Emeputa

Emeputa / onye na-eweta ihe / onye nyere ikike njikwa mma: Takeda Austria GmbH, Austria.

Art. Peter Strasse 25, 4020 Linz, Austria.

"Takeda Austria GmbH, Austria." Peter-Strasse 25, 4020 Linz, Austria.

Ma ọ bụ LLC Takeda Pharmaceuticals, 150066, Russia, Yaroslavl, ul. Technopark, 9.

Tẹ.: (495) 933-55-11, faksị: (495) 502-16-25.

Ma ọ bụ CJSC PharmFirma Sotex. 141345, Russia, Russia mpaghara, Sergiev Posad ọchịchị ime obodo, mmezi ime obodo Bereznyakovskoe, pos. Belikovo, 11.

Tel./fax: (495) 956-29-30.

Legallọ ọrụ iwu kwadoro aha ya nyere akwụkwọ ikike ịdebanye aha ya: Takeda Pharmaceuticals LLC. 119048, Russia, Moscow, ul. Usacheva, 2, p. 1.

Tẹ.: (495) 933-55-11, faksị: (495) 502-16-25.

[email protected], www.takeda.com.ru, www.actovegin.ru

Ekwesịrị izipu ndị na-azụ ahịa na adreesị ụlọ ọrụ iwu nke aha ha nyere akwụkwọ nnabata: Takeda Pharmaceuticals LLC, Moscow, Russia.

Mmetụta akụkụ

E kpebiri ugboro ole mmetụta ọ bụla dabere na nhazi nke Council of International Medical Scientific Organisation (CIOMS): oge ​​(≥ 1/10), ọtụtụ mgbe (≥ 1/100 ruo not anaghị egosi mmetụta ọjọọ) ọbụlagodi mgbe ọnụọgụ ahụ dị 30-40 ugboro karịa onunu ogwu achoro ka eji aru mmadu Emebeghi oria Actovegin ®.

Ntụziaka pụrụ iche

Data adakarị
Na ARTEMIDA multicenter, nke a na-ahụ anya, nke gbara okpukpu abụọ, ọmụmụ ihe na-achịkwa (NCT01582854), nke chọrọ ịmụ banyere ọgwụgwọ Actovegin ® na nkwarụ ọgbaghara na 503 ndị ọrịa ischemic strok, mkpokọta nke ihe ọghọm dị egwu na ọnwụ bụ otu ihe ahụ na otu ọgwụgwọ abụọ. Agbanyeghi ugboro ugboro ọrịa ọnya afọ ole a tụrụ anya na ndị ọrịa a, ọnụ ọgụgụ ka ukwuu ka etinyere na otu ahụ na-a theụ ọgwụ Actovegin compared ma e jiri ya tụnyere otu placebo, mana ọdịiche a abụghị nnukwu ọnụ ọgụgụ. E dobeghi mmekọrịta dị n'etiti okwu mkpọnwụ ugboro ugboro na ọgwụ ịmụzi.

Jiri na ọrịa ọrịa ụmụaka
Ugbu a, data maka iji ọgwụ ahụ Actovegin ® dị ụmụaka adịghị ya, yabụ akwadoghị ojiji maka otu a.

Mmetụta ikike ịkwọ ụgbọala na usoro ndị ọzọ
Etinyeghi.

Ihe njikwa / njikwa ngwaahịa

Takeda G MBH, Germany
Lenitzstrasse 70-98, 16515 Oranienburg, Germany
Takeda GmbH, Germany
Lehnitzstrasse 70-98, 16515 Oranienburg, Germany
ma obu
"Takeda Austria G MBH", Austria.
Art. Peter Strasse 25, 4020 Linz, Austria
Takeda Austria GmbH, Austria
St. Peter-Strasse 25, 4020 Linz, Austria
ma obu
Ọgwụ LLC Takeda Pharmaceuticals
Russia, 150066, Yaroslavl, ul. Technopark, d.9,
ma obu
CJSC PharmFirma Sotex
Russia, 141345, Moscow Mpaghara,
Sergiev Posad ọchịchị ime obodo,
mmezi ime obodo Bereznyakovskoe, pos. Belikovo, 11.

Weputara udi ya na ihe mebere ya

Ampules nwere mmiri doro anya ma ọ bụ nke edo edo maka ọgwụ mgbochi.

Ngwakọta ọrụ: hemoderivative deproteinized, 40 mg / ml.

Nke mepụtara site na akwara, nkewa na mkpo nke irighiri ọbara nke ụmụ anụmanụ na-eto, nyekwa mmiri ara ehi nanị.

Ihe mgbakwunye: mmiri maka ntinye.

Enwere ike imepụta ya site na ụlọ ọrụ ọgwụ Takeda Austria GmbH (Austria) ma ọ bụ Takeda Pharmaceuticals LLC (RF). Achịkọtara na 2 ml, 5 ma ọ bụ 10 ml na ampoules iko na-enweghị agba nke 5 PC. na ngwungwu ngwongwo eji rọba mee. Mkpụrụ ndụ ihe ndozi 1, 2 ma ọ bụ 5 n'ime igbe kaadi.

Ọgwụ ahụ bụ otu nke antihypoxants.

Na mpempe kaadiboodu ọ bụla kwesiri inwe mpempe akwụkwọ mpịakọta nwere ihe ndebiri holographic na ịchịkwa oghere mbụ.

Kedu ihe kpatara ya

Actovegin 40 gụnyere na usoro ọgwụgwọ mgbagwoju anya:

• nsogbu nke iche iche etiologies,
• nsogbu ọnyụnyụ ọbara na okpo iku ume na akwara,
• akụkụ angiopathy,
• ọrịa mamịrị na-arịa ọrịa mamịrị
• mwepu anụ ahụ (trauma, ịwa ahụ, ọnya nke akụkụ ala, wdg),
• nsonaazụ nke ọgwụgwọ radieshon.

Na mgbakwunye, iji ụdị usoro onti ogwu a, a na-agwọ gastritis na-egbu egbu, ọnya na-adịghị ala ala nke afọ na duodenum.

Actovegin 40 bụ akụkụ nke usoro ọgwụgwọ zuru oke maka ọrịa mberede ụbụrụ.
Edere ọgwụ ahụ maka ọrịa neuropathy mamịrị.
Iji ụdị usoro a, a na-agwọ ọnya afọ na nke duodenum.
A na-eji Actovegin agwọ ọrịa nsonaazụ radieshon.

Uzo esi ewere Actovegin 40

A na-ekpebi oge, usoro onyonyo na usoro ọgwụgwọ dabere na njirimara nke usoro pathological. Ekpebiela n’otu n’otu. Edere ya aha yabụ intraarterira, intravenia na intramuscularly.

N'ime usoro ọgwụgwọ nke ụbụrụ metabolic na vaskụla ụbụrụ, n'oge mmalite nke ọgwụgwọ, 10-20 ml nke iv ma ọ bụ iv na-abanye kwa ụbọchị. Mgbe ahụ, dịka usoro ọgwụgwọ si dị, 5 ml iv ma ọ bụ IM na infusion na-egbu oge.

Na ọrịa onchemic na oke oke, a na-enye ọgwụ.

Na ọrịa ischemic na ogbo, a na-eme infusus. Maka nke a, a na-etinye ọgwụ (10-50 ml) na 200-300 ml nke isotonic mejupụtara (5% glucose ma ọ bụ sodium chloride solution). Mgbe nke a gasịrị, a gbanwere usoro ọgwụgwọ iji were ụdị mbadamba ọgwụ.

Maka ọgwụgwọ nke ọnọdụ sitere na nkwarụ akwara ụbụrụ, a na-enye ọgwụ a iv ma ọ bụ iv (20-30 ml nke ọgwụ ahụ na 200 ml nke ihe mejupụtara isotonic).

Iji kpochapụ ihe nrịba ama nke polyneuropathy na-arịa ọrịa mamịrị, 50 ml iv bụ ọgwụ. Mgbe ahụ, ọgwụgwọ ọgwụgwọ gbanwere iji Actovegin na mbadamba.

Site na nchịkwa / m, a na-eji ihe ruru 5 ml. Tinye nwayọ.

Na-a drugụ ọgwụ maka ọrịa shuga

Na-ezo aka na ọgwụ ndị na-eme ka nhazi nke metabolism. Ya mere, ọ bụ amanyere bụ iwu na usoro ọgwụgwọ dị ala nke ọrịa shuga.

Ọgwụ a chọrọ n'ọgwụgwọ ọrịa shuga dị mgbagwoju anya.

Dodoụbiga ya ókè

Onweghi nsogbu ịdoụbiga mmanya ókè nke Actovegin.

A na-eji ya na ọgwụgwọ na mgbochi nke ọrịa hypoxic na ọrịa ischemic nke akụkụ na anụ ahụ na ndị ọrịa metụtara afọ.

Enwere enwere ike ịbawanye ụba nke ihe ndị ọ na-akpata.

Mmekọrịta na ọgwụ ndị ọzọ

Enweghị mmetụta ọjọọ site na njikọta ọgwụ.

Ọ dakọtara n'ụdị ọgwụ eji eme ihe na mgbagwoju anya nke ọgwụgwọ ọrịa ischemic (dịka ọmụmaatụ, ya na Mildronate).

Na mgbakwunye, a na-eji ya na atụmatụ jikọtara ọnụ na ọgwụ ọgwụ ndị a na-eji egbochi mkpụkọ venous na placental insufficiency, na ọgwụgwọ nke thrombosis (dịka ọmụmaatụ, ya na Curantil).

Mgwakọta chọrọ ịkpachara anya

Nchikota ya na ndi inhibitors ACE (Enalapril, Lisinopril, Captopril, wdg), ya na ihe ndi ozo eji edozi potassium choro ịkpachara anya.

Ndị nọchiri anya Actovegin bụ:

• Vero-Trimetazidine,
• Curantil-25,
• Cortexin
• Cerebrolysin, wdg.

Curantil-25 bụ analog nke Actovegin.

Actovegin Ahịa 40

Ọnụ ego ha dabere na olu ampoules na ọnụ ọgụgụ ha na ngwugwu. Ya mere, dịka ọmụmaatụ, na Russia, ọnụahịa nke Actovegin (ntụtụ maka ampoules 40 mg / ml nke 5 ml 5 pcs.) Dị iche site na 580 ruo 700 rubles.

Na Ukraine, ngwugwu yiri ya bụ ihe dịka 310-370 UAH.

Onu ogugu onu ogwu a dabere na olu ampoules na onu ogugu ha na ngwugwu.

Nyocha nke ndị dọkịta na ndị ọrịa na Actovegin 40

Echiche nke ndị dọkịta na ndị ọrịa gbasara ojiji, ịdị irè na nchekwa dị iche.

Vasilieva E.V., akparamaagwa akwara, Krasnodar

Actovegin enweghị ihe ọ bụla ọ na-akpata, ọ na-anabatakwa nke ọma. Enwere ike iji ya mee ihe na monotherapy ma na usoro ọgwụgwọ dị mgbagwoju anya. E nyefere ya usoro nke usoro akwara obi na ọdịda nke metabolic. Ana m akwado ọtụtụ ndị ọrịa.

Marina, 24 afọ, Kursk

Ha nyere ogwu ogbugba na obere mmiri n'oge ime ime ka obara di n’iru n’ile n’iru. Enweghị mmetụta ọ bụla. Mgbe ọgwụgwọ ya gachara, ọbara ọbara lọghachiri kwesịrị, ike gwụrụ ya na nkụda mmụọ ya na ọrịa ahụ gwụrụ. M na-adụ ụmụ nwanyị niile dị ime aka.

Nefedov I.B., gbara afọ 47, Oryol

N'agbanyeghị eziokwu ahụ bụ na FDA machibidoro ọgwụ a (Ngalaba Ahụike na Ọrụ Ọrụ US), a na-eji ya eme ihe na Russia na mba CIS. Ofesi nke ala ọzọ. Anaghị m atụkwasị obi na ọgwụ ike, ntuziaka maka nke na-egosi na ọ gaghị ekwe omume iji nyochaa akụrụngwa ọgwụ ya.

Afanasyev P.F. dibia bekee, St Petersburg

Ezigbo ọgwụ antihypoxic na ịchekwa nsonaazụ ọgwụgwọ maka ọnwa 3-6. A na-eji ngwá ọrụ a eme ihe n'ụlọ ọgwụ anyị na Institutelọ Ọrụ Nnyocha. Ankylosing spondylitis maka mkpochapu nke mgbaàmà nke ọrịa ụbụrụ na encephalopathy diski, nsonaazụ nke ọnya na ọnya ụbụrụ. Ọ na - enyere aka wepu isi ọwụwa, isi ọwụwa, mmetụta nke ụjọ, meziwanye ọrụ ọgụgụ isi, wdg.

Na-egosi Actovegin ®

Dika akụkụ nke usoro ọgwụgwọ mgbagwoju anya:

• nsogbu imerime onwe ya, gụnyere mmebi akwara ozi na ọgbụgba,
• nsogbu mgbasa ọbara na nsogbu ọ bụla,
• polyneuropathy na-arịa ọrịa mamịrị.

Usoro usoro onunu ogwu

A na-eji ọgwụ ahụ eme ihe na / a, na / na (gụnyere n'ụdị infusion) na / m.

Dabere ogo ịdị njọ nke onyonyo a, ị ga - ebu ụzọ tinye 10-20 ml nke ọgwụ na / n'ime ma ọ bụ na / ụbọchị, mgbe ahụ 5 ml n'ime / n'ime ma ọ bụ m, nwayọ, kwa ụbọchị ma ọ bụ ọtụtụ ugboro n'izu.

Maka nchịkwa infusion, site na 10 ruo 50 ml nke ọgwụ ahụ kwesịrị ịgbakwunye 200-300 ml nke isi ihe ngwọta (isotonic sodium chloride solution ma ọ bụ 5% glucose ngwọta). Ọnụego ya bụ ihe dị ka 2 ml / min.

Maka injections v / m, eji ihe karịrị 5 ml nke ọgwụ ahụ, nke ekwesịrị iji nwayọ nwayọ mee ya, ebe ọ bụ na ngwọta ya bụ hypertonic.

Na oge nsogbu ischemic strok (malite na ụbọchị 5-7) - 2000 mg / day in / drip to 20 infusions with a transition to a form of 2 tablet. 3 ugboro / ụbọchị (1200 mg / ụbọchị). Oge ngụkọta nke ọgwụgwọ bụ ọnwa 6.

Na ọrịa dementia - 2000 mg / day in / drip. Ogologo ọgwụgwọ ya dị izu anọ.

N'ọnọdụ nsogbu nsogbu mgbasa gburugburu na nsonazụ ha - 800-2000 mg / day in / a ma ọ bụ na / na ntapu. Ogologo ọgwụgwọ ya dị izu anọ.

Na polyneuropathy na-arịa ọrịa mamịrị - 2000 mg / day iv / drip nke infusions 20 na ntughari na ụdị mbadamba 3 mbadamba. Ugboro atọ / ụbọchị (1800 mg / ụbọchị). Oge ọgwụgwọ ọ dị site na ọnwa anọ ruo ọnwa ise.

Ntụziaka maka iji ampoules nwere ebe ezumike

Debe isi ampoule ahụ elu.

Jiri nwayọ jiri mkpịsị aka wee kpoo ampoule ahụ, kwe ka ngwọta ga-agbada site n'ọnụ ọnụ ampoule ahụ.

Jidesie ampoule aka aka n'otu aka ya, were n'aka nke ọzọ, bibie ọnụ ụzọ ampoule ahụ n'ebe ntụpọ.

Ihe ngbanwe

• ọgwụ mgbochi Actovegin ®, ọgwụ ndị yiri ya ma ọ bụ ndị ochie,
• obi erughị ala,
• edem edere,
• oliguria, anuria,
• njikwa mmiri na ahụ,
• ụmụaka na ndị ntorobịa erubeghị afọ iri na asatọ.