Ọrịa shuga mellitus

Thatzọ nke na-enye ohere ịchọpụta mbufe hyperglycemia gụnyere mkpebi nke protein glycosylated, oge ọnụnọ nke anụ ahụ sitere na izu abụọ ruo izu iri na abụọ. N'ịkpọtụrụ glucose, ha na-agbakọta ya, dị ka a pụrụ isi kwuo ya, ụdị ebe nchekwa na-echekwa ozi gbasara ọkwa glucose n'ọbara ("Nchekwa glucose ọbara"). Hemoglobin A n'ime ndị ahụ nwere ahụike nwere obere akụkụ haemoglobin A1c, nke gụnyere glucose. Ọnụ ọgụgụ nke haemoglobin glycosylated (HbA1c) bụ 4-6% nke ngụkọta hemoglobin.

N'ime ndị ọrịa nwere ọrịa mellitus nke nwere hyperglycemia na-adịgide adịgide na ịnagide glucose na-adịghị ala ala (ya na hyperglycemia transient), usoro nke itinye glucose na molikula haemoglobin na-abawanye, nke a na-agbakwunye na mmụba nke irighiri ihe HbAic. N’oge na-adịbeghị anya, achọpụtara ụmụ obere irighiri haemoglobin ndị ọzọ, Ala na A1b, ndị nwekwara ikike iji glucose achọpụtala. N'ime ndị ọrịa nwere mellitus ọrịa shuga, ngụkọta nke haemoglobin A1 n'ime ọbara karịrị 9-10% - njirimara bara uru nke ndị mmadụ nwere ahụ ike.

Ọrịa hyperglycemia dị obere na-agbago na ọkwa nke hemoglobin A1 na A1c ruo ọnwa 2-3 (n'oge ndụ nke sel ọbara) na mgbe ọ gbasasịrị ọkwa shuga dị n'ọbara. A na-eji kromograf nke kọlụji ma ọ bụ usoro calorimetry ikpebi haemoglobin glycosylated.

Nkowaputa IRI

Nwalee tolbutamide (dika Unger na Madison siri kwuo). Mgbe ituchara shuga ọbara n’afọ na-enweghị isi, a na-enye 20 ml nke 5% ihe ngwọta nke tolbutamide n’arụ onye ọrịa ahụ ma ka ọ jiri nkeji iri atọ gụgharịa shuga ọbara. N’ime ndị ahụ siri ike, ọnụego shuga dị n’ọbara karịrị 30%, yana n’ime ndị ọrịa nwere ọrịa shuga - erughị 30% nke ọkwa mbụ. N'ime ndị ọrịa insulinoma, shuga ọbara na-agbada karịa 50%.