Etu esi eji Telmista 40? > Ọgwụgwọ na mgbochi

Usoro onunu ogwu Telmists - mbadamba: ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ ọcha, na nha nke 20 mg - okirikiri, 40 mg - biconvex, oval, 80 mg - biconvex, ekpuchie okpu (na ọnya ngwongwo 7 pcs., N'ime igbe kaadi 2, 4, 8 , Blisters iri na abụọ ma ọ bụ iri na anọ na pọọsụ 10, n'ime igbe kaadi 3, 6 ma ọ bụ blisters 9).

Ngwakọta nke otu mbadamba:

ihe na-arụ ọrụ: telmisartan - 20, 40 ma ọ bụ 80 mg,
ndị na - ahụkarị: sodium hydroxide, lactose monohydrate, magnesium stearate, meglumine, povidone K30, sorbitol (E420).

Mlọ ọgwụ

Telmisartan, ihe na-arụ ọrụ na Telmista, nwere akụ antihypertensive, ebe ọ bụ onye nnabata angiotensin II antagonist (AT blocker₁ndị nabatara). Na-ekpughe angiotensin nke II site na njikọ ya na onye na-anabata ya, ọ nweghị ọrụ nke nnabata gbasara nkwanye nnabata a. Telmisartan selectively na ogologo oge nwere ike jikọ aka na angiotensin II receptor subtype AT₁. O nweghi nmekorita ya nye ndi nnabata angiotensin ndi ozo, ihe bara uru banyere ya na ihe ndi kari (nihi uto nke telemisartan) nke angiotensin II n’abu banyere ha.

Telmisartan na -ebelata mkpokọta nke aldosterone na plasma ọbara, anaghị emetụta ịta nke renin ma anaghị egbochi ọwa ion. Ihe na-arụ ọrụ anaghị egbochi ACE (angiotensin-enzyme ntụgharị), nke na-ebibikwa bradykinin, yabụ enweghị mmeghachi omume n'akụkụ nke kpatara bradykinin.

Telmisartan, nke a na-etinye ya na 80 mg, na-egbochi mmetụta ọbara mgbali elu nke angiotensin II. Mgbe ị firstụ ọgwụ mbụ ahụ ruo awa 3, achọpụtala mmalite nke mmetụta hypotensive, nsonaazụ ahụ na-adịgide otu ụbọchị, ọ ka dị ọhụhụ ruo ụbọchị abụọ. A ike hypotensive mmetụta na-amalite mgbe 4-8 izu site na mmalite nke ọgwụgwọ na mgbe nile nke telmisartan.

Site n'ọbara mgbali elu, ọgwụ a na - enyere aka belata systolic na ọbara mgbali ọbara (BP). Telmisartan enweghị mmetụta ọ bụla na nha obi (ọnụego obi).

N'ime ndị ọrịa nwere kagbuo telmisartan na mberede, ọbara mgbali ji nwayọọ nwayọọ laghachi na uru mbụ ya, a naghị achọpụta ọrịa ndọrọ ego.

Mlọ ọgwụ

ịmịkọrọ: mgbe a gbanyere ya mkpọrọ, ọ na-abanye ngwa ngwa na eriri afọ. Bioavailability bụ 50%. Mgbe ejiri nri, mbelata nke AUC (mpaghara dị n'okpuru usoro ọgwụ pharmacokinetic) dị na 6% ruo 19% na ogo 40 na 160 mg, n'otu n'otu. 3 awa mgbe ọ gbasịrị telmisartan, uche ya na ọkwa plasma ọbara (apụtaghị n'oge iri nri). AUC na plasma kachasị nke ihe ahụ (C_max) n'ime ụmụ nwanyị dịka ihe dịka 2 na ugboro atọ karịa, karịa, n'ime ụmụ nwoke. Enweghị mmetụta dị ukwuu na arụmọrụ,
nkesa na metabolism: 99.5% nke ihe ahụ jikọtara na protein plasma (tumadi alfa-1 glycoprotein na albumin). Olu doro anya nke ekesara na nhazi ịha bụ ọkara 500 l. Metabolism na-eme site na conjugation na glucuronic acid na nguzobe nke metabolites adịghị arụ ọrụ metabolites,
mpụga: T_1/2 (iwepu ọkara ndụ) - ihe karịrị elekere iri abụọ. Isi ihe na - agbanweghi agbanwe n’ime eriri afọ ya na mmamịrị - erughị 2%. Mkpokọta plasma zuru oke ma e jiri ya tụnyere ọbara ọgbụgba na -akpata (ihe dịka 1500 ml / min) yana ihe dịka 900 ml / min.

Ihe bụ ọgwụ pharmacokinetic bụ isi nke telmisartan mgbe eji ya na ụmụaka na ụmụaka nọ n’agbata afọ isii ruo afọ iri na asatọ maka izu nke 4 ma ọ bụ 2 mg / n'arọ ka atụnyere ndị nọ n’ozi ndị okenye ma kwado ọgwụ pharmokokinetics na-abụghị linear nke ihe dị n’ọrụ, ọkachasị n’ihe gbasara C_max.

Ihe ngbanwe

ụdị siri ike nke nsị imeju (dịka nhazi nke nwata - Pugh - klas C),
bile du mgbochi,
jikọtara iji ya na aliskiren na ndị ọrịa nwere nnukwu akwara azụ ma ọ bụ agafeghị oke (ọnụego nzacha ụwa na-erughị 60 ml / min / 1.73 m 2) ma ọ bụ na-arịa ọrịa shuga mellitus.
ụkọ lactase / sucrose / isomaltase, enweghi ike fructose, glucose-galactose malabsorption,
afọ ime na lactation,
afọ ruo afọ 18
ọgwụ mgbochi onwe onye na telmisartan ma ọ bụ ihe ọ bụla nke inyeaka ọgwụ ahụ.

Ikwu (oria / ọnọdụ nke ojiji nke Telmista chọrọ ịkpachara anya):

arụ ọrụ akwara na / ma ọ bụ ọrụ imeju,
Stenosis abụọ akụrụngwa akwara ma ọ bụ stenosis nke otu akụrụ,
Ọnọdụ mgbe akụrụ akụrụ (n'ihi enweghị ahụmịhe eji ya eme ihe),
hyperkalemia
hyponatremia,
ike ọgwụgwụ nke obi
warara nke ntule mital na / ma obu aortic valve,
GOKMP (ọnya na-egbochi hypertrophic ihe mgbochi ọbara),
mbelata nke ịba ọcha (olu ọbara na - ekesa) n'ihi ọgwụgwọ ọgwụgwọ ya na mbụ ya, ya bụ, oke nnu, ọgbụgbọ ma ọ bụ afọ ọsịsa.
hyperaldosteronism izizi (nchekwa na nrụpụta adịghị ike).

Ntụziaka maka iji Telmista: usoro na usoro onunu ogwu

Ana a tabletsụ mbadamba Telmist ọnụ, n'agbanyeghị oge nri.

Site n'ọbara mgbali elu, a na-atụ aro ka ịmalite were ọgwụ 20 ma ọ bụ 40 mg ọgwụ 1 oge kwa ụbọchị. N'ime ụfọdụ ndị ọrịa, ọ ga-ekwe omume nweta mmetụta hypotensive na dose nke 20 mg / ụbọchị. N'ọnọdụ ezughi oke ọgwụgwọ, ị nwere ike ịbawanye dose ahụ ruo n’obere ụbọchị kwa ụbọchị nke 80 mg. Site na mmụba na dose, ekwesịrị iburu n'uche na mmetụta kachasị ike nke Telmista bụ nke a na-enwetakarị mgbe izu 4-8 sitere na mmalite ọgwụgwọ.

Iji belata ọrịa obi na akwara, ọ na-atụ aro ka ị mgụọ ọgwụ mg 80 na ọgwụ 1 oge kwa ụbọchị.

Na usoro ọgwụgwọ mbụ, enwere ike ịchọ usoro ndị ọzọ iji mesoo ọbara mgbali elu.

Ọ dịghị mkpa ka ịhazigha usoro usoro ọgwụgwọ maka ndị ọrịa nwere ọdịda akụrụngwa, gụnyere ndị nọ na hemodialysis.

Maka ọrụ imeju na-arụ ọrụ nke ịdị nfe ma ọ bụ na-adịghị agafe agafe (dị ka nhazi nke ụmụaka-Pugh - Klas A na B), ọgwụ kachasị na Telmista kwa ụbọchị bụ 40 mg.

N'ime ndị ọrịa agadi, ọgwụ ọgwụ nke telmisartan adịghị agbanwe, yabụ na ọ dịghị mkpa ịgbanwe nhazi nke ọgwụ maka ha.

Nsonaazụ

Mgbe ị na-eji Telmist, mmeghachi omume ndị na-esote usoro na akụkụ ahụ ga-ekwe omume:

obi: tachycardia, bradycardia,
arịa ọbara: hyperension orthostatic, mbelata ọbara mgbali elu,
Usoro nri: afọ ọsịsa, mgbu afọ, dyspepsia, afọ erughị ala, flatulence, vomiting, dysgeusia (ngụgụ nke uto), akọrọ mucous nke onu ura, ọrịa akwara na-arụ ọrụ / ọrịa imeju,
ọbara na sistem lymphatic: thrombocytopenia, eosinophilia, anaemia, sepsis (gụnyere sepsis na-egbu),
ụjọ usoro: ehighị ụra, nchekasị, ịda mba, vertigo, ịkụda mmụọ,
usoro ahụ ji alụso ọrịa ọgụ: hypersensitivity (urticaria, erythema, angioedema), mmeghachi omume anaphylactic, pruritus, eczema, ọnya anụ ahụ (gụnyere ọgwụ), hyperhidrosis, angioedema (ruo ọnwụ), akpịrị anụ ahụ na-egbu egbu,
ahu nke anya:
sistem iku ume, obi na akụkụ ahụ mmadụ: ụkwara, mkpụmkpụ ume, ọrịa iku ume nke elu, ọrịa ọrịa ngụgụ (mmekọrịta a na-eji telmisartan etinyere),
akwara anụ ahụ na akwara anụ ahụ: azụ mgbu, arthralgia, olu mgbu (spasms nke akwara nke nwa ehi), myalgia, mgbu ụkwụ, ihe mgbu na akwara (mgbaàmà yiri ngosipụta nke ọnya na mmebi nke akwara anụ ahụ),
akụrụ na urinary tract: ọrụ akụrụ na-arụ ọrụ (gụnyere nnukwu ọrịa gbasara akwara), ọrịa urinary tract (gụnyere cystitis),
ahụ niile: adịghị ike izugbe, ọrịa na-efe efe, obi mgbu,
Ọmụmụ ihe nyocha na akụrụngwa: mmụba na ọdịnaya uric acid, creatinine na plasma ọbara, mbelata ọkwa nke hemoglobin, mmụba na ọrụ nke ọrịa hepatic transaminases, CPK (creatine phosphokinase) na plasma ọbara, hypoglycemia (na ndị ọrịa nwere ọrịa mellitus), hyperkalemia.

E guzobeghi mmekọrịta nke ogo ngosipụta nke ihe mmetụta na afọ, okike ma ọ bụ agbụrụ ndị ọrịa.

Ntụziaka pụrụ iche

Ojiji nke Telmista na ACE inhibitors ma ọ bụ onye na-egbochi nnabata nke renin, aliskiren, n'ihi ihe ahụ ugboro abụọ na RAAS (usoro renin-angiotensin-aldosterone) na-eme ka akụrụ na-arụ ọrụ akwara (gụnyere nwere ike ịkpata nnukwu akwara ọdịda), na-emekwa ka ohere nke hypotension na hyperkalemia dịkwuo njọ. . Ọ bụrụ na ọgwụgwọ nkwonkwo dị otú ahụ dị ezigbo mkpa, a ga-eme ya n'okpuru nlekọta ahụike yana yana ilele ọrụ akụrụ, ọbara mgbali elu na ọkwa electrolyte na plasma ọbara.

N'ime ndị ọrịa nwere ọrịa nephropathy, telmisartan na ACE inhibitors anaghị atụ aro ya.

N'ọnọdụ ebe ụda olu na ọrụ akụrụ na-adabere na ọrụ nke RAAS (dịka ọmụmaatụ, na ndị ọrịa nwere ọrịa akụrụ, gụnyere akwara abụọ akwara akwara ma ọ bụ stenosis nke otu akụrụ akwara, ma ọ bụ na obi na-adịghị ala ala), iji ọgwụ ọjọọ eme ihe na-emetụta RAAS nwere ike iduga mmepe nke hyperazotemia, hypotension hypotension, oliguria na nnukwu gbasara akụrụ afọ n’ala (n’ọnọdụ ndị dị ụkọ).

Mgbe ị na-eji ọgwụ ndị na-enye potassium, ọgwụ nnu na mmanụ, ihe mgbakwunye na ọgwụ ndị ọzọ na-eme ka mkpokọta potassium na plasma ọbara na-arụkọ ọrụ na Telmista, ọ dị mkpa ijikwa ọkwa nke potassium na ọbara.

Ebe ọ bụ na telmisartan na-apụtakarị na ọnya ọnya, nke nwere ọrịa na-egbochi ọnya biliary ma ọ bụ ọrụ imeju na -akpọ, belata nchacha nke ọgwụ ga-ekwe omume.

Site na ọrịa shuga na ọrịa obi nke ọzọ, dịka ọmụmaatụ, akwara obi (ọrịa obi obi), ojiji nke Telmista nwere ike ịkpata nnukwu ọrịa myocardial infarction na ọnwụ obi mberede. N'ime ndị ọrịa nwere ọrịa mellitus nke ọrịa shuga, ọrịa obi nwere ike ghara ịchọpụta, ebe ọ bụ na ihe mgbaàmà ya na nke a anaghị adịkarị. Ya mere, tupu ịmalite ọgwụgwọ ọgwụ, ọ dị mkpa iji nyochaa nyocha dị mma, gụnyere nnwale na mmega ahụ.

N'ime ndị ọrịa nwere ọrịa shuga na-anata insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ, hypoglycemia nwere ike ịmalite n'oge ọgwụgwọ na Telmista. Ọ dị ndị ọrịa dị otú a mkpa ịchịkwa mkpokọta nke glucose n'ọbara, ebe ọ bụ na dabere na ngosipụta a, a ga-agbanwe nhazi nke insulin ma ọ bụ ọgwụ hypoglycemic.

Na hyperaldosteronism bụ isi, iji ọgwụ antihypertensive - RAAS inhibitors - anaghị adịkarị mma. A naghị atụ aro ka ndị ọrịa dị otú ahụ were Telmista.

Ojiji nke ọgwụ ahụ ga-ekwe omume na njikọ turezide diuretics, ebe ọ bụ na ngwakọta dị otú a na-enye mbelata mgbakwunye ọbara mgbali elu.

Nnyocha e mere egosiwo na Telmista adịghị ike na ndị ọrịa nke agbụrụ Negroid. A hụrụ mkpochasị nke imeju site na iji telmisartan n'ọtụtụ oge n'etiti ndị bi na Japan.

Ime na lactation

Dabere na ntuziaka ahụ, a na-egbochi Telmista n'oge afọ ime. N'ihe banyere nchọpụta afọ ime, ọgwụ a ga-akwụsị ozugbo. Ọ bụrụ na ọ dị mkpa, a ga-enye ọgwụ ọgwụ antihypertensive nke klaasị ndị ọzọ akwadoro maka iji ya n'afọ. A na-adụ ndị inyom na-eme atụmatụ ịtụrụ ime ume ka ha jiri usoro ọgwụgwọ ọzọ.

N'ime nyocha nke ọgwụ ahụ, achọpụtaghị mmetụta teratogenic. Mana achọpụtara na ojiji nke angiotensin II receagonor antagonists na nke abụọ na nke atọ nke afọ ime na - akpata fetotoxicity (oligohydramnios, belata ọrụ gbasara ọrụ, jiri nwayọ nwayọ n’ọkpụkpụ nke nwa ebu n'afọ) na oke nsí nke mkpụrụ ndụ (hypotension hypotension, kelal failure, hyperkalemia).

Newmụ amụrụ ọhụrụ ndị nne mụrụ Telmista n'oge afọ ime chọrọ nlekọta ahụike n'ihi mmepe nke hypotension akwara ike.

Ebe o nweghi ihe omuma banyere n’ime uzo nke telmisartan n’ime mmiri ara, ogwu a na - enye ogwu n’oge nri.

Na arụ ọrụ imeju

A naghị atụ aro ị theụ ọgwụ ahụ na ndị ọrịa nwere ọrụ imeju na-arụ ọrụ dị ukwuu (dị ka nhazi ọkwa nke ụmụaka-Pugh - klas C).

Site na ụkọ ịba ọcha ọ bụla na-erughị ala (dị ka nhazi ụmụaka-Pugh - Klas A na B), ojiji nke Telmista chọrọ ịkpachara anya. Maximumgwọ ọgwụ kwa ụbọchị kachasị na nke a ekwesịghị ịfe 40 mg.

Mkparịta ụka ọgwụ ọjọọ

Ojiji nke telmisartan n'otu oge na ọgwụ ụfọdụ nwere ike iduga mmepe nke mmetụta ndị a:

antihypertensive ọgwụ: ụba antihypertensive utịp,
warfarin, digoxin, ibuprofen, glibenclamide, hydrochlorothiazide, paracetamol, amlodipine na simvastatin: a hụghị mmekọrịta dị ịrịba ama na ụlọ ọgwụ. N'ọnọdụ ụfọdụ, mmụba nke ọdịnaya digoxin plasma site na nkezi nke 20% ga-ekwe omume. Ejikọtara ya na digoxin, a na-atụ aro ka inyocha ihe gbasara plasma ya kwa oge,
Mgbakwunye potassium-sparing diuretics (dịka ọmụmaatụ, spironolactone, amiloride, triamteren, eplerenone), ndị nọchiri potassium, ndị ACE inhibitors, angiotensin II receptor antagonists, NSAIDs (ọgwụ mgbochi ọgwụ na-abụghị steroid), gụnyere nhọrọ cyclooxygenase-hemporin-2-azimonpin-cyimpin na trimethoprim: ịba ụba nke hyperkalemia (n'ihi mmetụta synergistic),
ramipril: mmụba okpukpu abụọ nke ndị na-egosi C_max na AUC_0-24 ramipril na ramiprilat,
Nkwadebe nke lithium: mmụba nke mbugharị nke ịgwakọta lithium na plasma ọbara (a kọpụtawo n'ọnọdụ ndị dị ụkọ) yana nsonaazụ na-eso ya. A na-atụ aro ka ị na-elele ọkwa plasma nke lithium kwa oge,
NSAIDs (gụnyere acetylsalicylic acid, NSAIDs na-ahọrọghị na cyclooxygenase-2 inhibitors): belata mmetụta hypotensive nke telmisartan, mụbaa ihe ize ndụ nke ọdịda akwara ọdịda n'oge nkụda mmụọ. Na mbido nchikota ọgwụ na telmisartan na NSAIDs, ọ dị mkpa iji kwụọ ụgwọ maka bcc wee lelee ọrụ akụrụ,
amifostine, baclofen: potenti nke mmetụta hypotensive nke telmisartan,
barbiturates, mmanya, antidepressants na ọgwụ: nhụjuanya hypotension orthostatic.

Ihe anaemọrọ nke Telmista bụ: Mikardis, Teseo, Telmisartan-Richter, Telmisartan-SZ, Telpres, Telsartan na ndị ọzọ.

Mpempe usoro onunu ogwu

Otu mbadamba ihe

Telmista®H40

bekee arụ ọrụ: Telmisartan 40mg

hydrochlorothiazide 12.5 mg

ndị mbụ: meglumine, sodium hydroxide, povidone K30, lactose monohydrate, sorbitol, magnesium stearate, mannitol, iron oxide red (E172), hydroxypropyl cellulose, anhydrous colloidal silicon dioxide, sodium stearyl fumarate

Telmista®H80

bekee arụ ọrụ: Telmisartan 80mg

hydrochlorothiazide 12.5 mg

Telmista®ND 80

bekee arụ ọrụ: telmisartan 80 mg

hydrochlorothiazide 25 mg

ndị mbụ: meglumine, sodium hydroxide, povidone K30, lactose monohydrate, sorbitol, magnesium stearate, mannitol, iron oxide yellow (E172) hydroxypropyl cellulose, anhydrous colloidal silicon dioxide, sodium stearyl fumarate

Mbadamba ụrọ, biconvex, bilayer, site na ọcha ruo ihe na-acha ọcha ma ọ bụ pinkish-white na agba dị n'otu akụkụ na pink-marble n'akụkụ nke ọzọ (maka onunu ogwu nke 40 mg / 12.5 mg na 80 mg / 12.5 mg).

Mbadamba ụrọ, biconvex, okpukpu abụọ, site na ọcha ruo na-acha oji na agba n’otu akụkụ ya na mabul-edo edo n’akụkụ nke abụọ (maka onunu ogwu nke 80 mg / 25 mg).

Ngwongwo ogwu

Mlọ ọgwụ

Nleta elu nke telmisartan na nchịkwa ọnụ a na-enweta mgbe awa 0,5-1.5 gachara. Ezigbo bioavailability nke telmisartan na doses nke 40 mg na 160 mg bụ 42% na 58%, otu isi. Foodnweta nri n'otu oge anaghị belata bioavailability nke telmisartan, na-ebelata mpaghara n'okpuru ọgwụ kachasị elu nke ọgwụ na plasma ọbara (AUC) ihe dị ka 6% mgbe ị na-ewere 40 mg na ihe dị ka 19% mgbe ịghasịrị 160 mg. Obere mbelata nke ịta ahụ anaghị emetụta nrụpụta ọgwụgwọ nke ọgwụ. The pharmacokinetics nke telmisartan mgbe a na-eji ọnụ nye ya n'ime usoro nke 20-160 mg bụ enweghị, Cmax na AUC na-abawanye na oke ịba ụba. N'iji ya ugboro ugboro, telmisartan na-agbakọta na plasma ọbara.

Telmisartan na-ejikọ nke ọma na protein plasma (> 99.5%), tumadi albumin na glcoproteins alpha L-acid. Olu ya doro anya na nkesa telmisartan ruru 500 L, nke na-egosi ịgbakwunye agbatị ọzọ.

Ihe karịrị pasent 97% nke ọgwụ mgbe ejiri ọnụ na-ekwu ya bụ oria a na-eme site na mpụta biliary. A na-ahuta uzo n’ime mmamiri. A na-agbanye Telmisartan site na conjugation na ọgwụ ọgwụ na-adịghị arụ ọrụ - acetyl glucuronides. Glucuronides bụ naanị metabolites nke ihe amalite n'ime ahụ mmadụ.

Mgbe otu larịị nke telmisartan, ihe glucuronides na plasma ọbara dị ihe dị ka 11%. A na-ejikọghị Telmisartan site na isoenzymes nke usoro cytochrome P450. Ibelata ikike sitere na plasma ọbara karịrị 1500 ml / min. Ọnọdụ ọkara ndụ nke ihe karịrị awa 20

Site na nchịkwa ọnụ nke njikọta nke telmisartan / hydrochlorothiazide, ọnụ ọgụgụ hydrochlorothiazide ruru na awa 1.0-3.0 mgbe nchịkwa ahụ gasịrị. N'iburu n'uche na hydrochlorothiazide nwere ike ịgbakọ n'oge mkpịsị akwara, ezigbo bioavailability bụ 60%.

Hydrochlorothiazide bụ ihe nchebe 68% na protein plasma na oke o kesara nkesa ya bụ 0.83-1.14 l / kg.

Hydrochlorothiazide adịghị metabolized ya ma ọ dịkarịa ala ịpụgharị na akụrụ na mmamịrị na-agbanweghi. Ihe dị ka pasent 60 nke ọgwụ a na-agbanweghị agbanwe n'ime awa asatọ

Ndụ ọkara nke hydrochlorothiazide bụ awa 10-15.

Mlọ ọgwụ

Nchikota telmisartan / hydrochlorothiazide bụ ngwakọta nke antagonistin II receptor antagonist, telmisartan na thiazide diuretic, hydrochlorothiazide, nke na-enye ọkwa dị elu nke mmetụta antihypertensive karịa iburu akụkụ nke ọ bụla iche. Mgbe ị na-ejikọkọta nke telmisartan / hydrochlorothiazide otu ugboro n'ụbọchị, mmerụ ahụ dị mma ma dịkwa mma n’ime ọbara ọgbụgba n’ime usoro ọgwụgwọ dị.

Telmisartan dị irè mgbe a na -ekwu ya okwu ọnụ ma bụrụkwa onye doro anya (nke ana - ahọ ọrụ) nke angiotensin II receptor subtype 1 (AT1). Telmisartan dochie angiotensin II, ebe ọ nwere ezigbo mmekọrịta dị n'etiti ndị na-anabata AT1 na saịtị nke na-ejide ya, bụ ndị na-ahụ maka ntọala guzosiri ike nke angiotensin II. Telmisartan na-ahọrọ ma na-ejikọkwa ya na ndị na-anabata AT1 ma ọ nweghị mmekọrịta maka ndị na-anabata ndị ọzọ, gụnyere AT2 na ndị ọzọ AT na-anabata ya. E guzobebeghị ọrụ dị mma nke ndị na-anabata ndị a, yana mmetụta ha na hyperstimulation nke angiotensin nke abụọ, ọkwa nke na-abawanye n'okpuru ọrụ nke telmisartan. Telmisartan belatara ọkwa plasma aldosterone ma ọ dịghị egbochi ọrụ nke enzyme angiotensin-na-agbanwe (kininase II), ya na ntinye ya na-ebelata nsụkọta bradykinin, yabụ iko nke mmetụta ọjọọ nke bradykinin anaghị eme.

Inhibido angiotensin nke II megidere ndabere nke telmisartan dịruru ihe karịrị awa 24 ma ọ ga-eru awa 48.

Mgbe ị gachara telmisartan, a na-arụ ọrụ antihypertensive n'ime awa 3. Mbelata kachasị nke ọbara mgbali elu ka etinyere izu 4-8 mgbe mmalite ọgwụgwọ wee gaa n'ihu n'oge usoro ọgwụgwọ ogologo oge. A nọgidere na-enwe mmetụta antihypertensive n'ọkwa mgbe niile awa 24.

N'ime ndị ọrịa nwere ọbara mgbali elu, telmisartan na-ebelata ma mgbagha ọbara systolic na diastolic n'emeghị ọnụego obi.

Site na mbelata nke ọgwụgwọ na telmisartan, ọbara mgbali na-eji nwayọ alaghachi na ọkwa ya ka ọ dị ọtụtụ ụbọchị na-enweghị mmepe nke “nwughari ọrịa” (mmụba dị elu nke ọbara mgbali).

Thiazides na-emetụta nlọghachi nke electrolytes na tubules nke akụrụ, na-eme ka mmịpụta sodium na chlorides na-abawanye nha. Mmetụta diuretic nke hydrochlorothiazide na-eduga n'ịbelata ọkwa plasma ọbara, mmụba na ọkwa plasma renin, mmụba nke ihe omimi aldosterone, nke na-enye aka na mmụba nke mmamịrị nke potassium na bicarbonates na, n'ihi ya, mbelata na ọkwa potassium. Ihe mgbochi nke renin-angiotensin nke usoro aldosterone na ijikọ ọnụ nke telmisartan ya na diuretics na-eduga n'iwe ọgwụ nwere ike iweghachi ọgwụ ahụ. Mgbe ị na-ewere hydrochlorothiazide, diuresis na-amalite mgbe awa 2 gachara, a na-enweta nsonaazụ diuretic kachasị 4 awa mgbe nchịkwa, ihe a na-ewe awa 6-12.

Ihe ngosi maka ojiji

- ọgwụgwọ nke ọbara mgbali elu

A na-egosi Telmista®H40 na Telmista®H80 maka ndị ọrịa na-enweghị ike ijikwa ọkwa ọbara mgbali elu site na iji telmisartan ma ọ bụ hydrochlorothiazide n'ụdị monotherapy.

A na - egosi Telmista® ND80 maka ndị ọrịa toro eto ebe ọ na - enweghị ike ijikwa ọkwa ọbara mgbali elu site na iji Telmista® N80 ma ọ bụ onye kwalitere nrụgide ahụ na mbụ site na iji telmisartan na hydrochlorothiazide iche.

Usoro onunu ogwu na nhazi

Ekwesịrị iji Telmista®N40, Telmista®N80 ma ọ bụ Telmista®ND80 otu ugboro kwa ụbọchị, were obere mmiri sachaa ya, n'agbanyeghị nri ị na-eri.

Tupu usoro ọgwụgwọ telmisartan / hydrochlorothiazide kwesịrị ime

uzo eji aru oru ya na telmisartan. Ọ bụrụ na ọ dị mkpa, ịnwere ike ịgbanwe site na monotherapy wee gwọọ ya na ngwakọta nke ọgwụ ole enyere.

Enwere ike inye ọgwụ Telmista®H40 ka ndị ọrịa ọbara mgbali ọbara na-achịkwaghị nke ọma.

Enwere ike ịkọwa Telmista® H80 maka ndị ọrịa ọbara mgbali ọbara na -achọpụtaghị site na 80 mg telmisartan.

Enwere ike ịgwọta Telmista® ND80 nye ndị ọrịa na-ejighị ọkwa Telmista® N80 na-achịkwa ọbara ọgbụgba ọfụma ma ọ bụ ebe enwere nrụgide ya na mbụ site na iji telmisartan na hydrochlorothiazide iche.

Mgbe ịmalite ọgwụgwọ na njikọta nke telmisartan / hydrochlorothiazide, a na-enweta mmetụta antihypertensive kachasị n'etiti izu anọ 4-8. Ọ bụrụ na ọ dị mkpa, enwere ike ịkọwa Telmista®H40, Telmista®H80 ma ọ bụ Telmista®ND80 na ngwakọta ọzọ.

Ọrịa enweghị akụrụ

A na-atụ aro ka ileba anya n'ihe gbasara akụrụngwa.

Ndị ọrịa nwere ọrịa imeju

N'ime ndị ọrịa nwere nsogbu ịba ọcha n'anya na-agafe agafe na oke, dose ahụ ekwesịghị gafere 1 mbadamba Telmista®N40 (telmisartan 40 / hydrochlorothiazide 12.5 mg) otu ugboro n'ụbọchị.

Ọchọgaghị ọgwụgwọ ọ bụla achọrọ n'ime ndị ọrịa agadi.

Omume ọgwụ

Mbadamba Telmista - ọgwụ dị irè maka nrụgide, nwere ọnụahịa dị ọnụ ala.

Ebumnuche ya bụ igbochi ndị nabatara ụdị AT1, ebe ọ naghị emetụta ụdị ndị ọzọ nnabata.

Mmetụta hypotensive kachasị nke ị Telụ Telmista ka achọpụtara mgbe ọnwa ọgwụ gasịrị, nke na-egosi mmetụta ọgwụ ga-agbatị.

Ngwongwo nke ogwu ahu sitere na mmekorita nke telmisartan na ihe hydrochlorothiazide, nke bu ihe diuretic. Ọgwụ bụ ụdị anabatacha ihe na-eme ihe anakpọ angiotensin ii. Akụkụ ahụ na-arụ ọrụ nke ọgwụ ahụ nwere mmekọrịta dị ogologo na onye na-anabata AT1.

Ọgwụ na-ebelata oke nke aldosterone na plasma ọbara. Ọgwụ na-ebelata oke nke aldosterone na plasma ọbara. Enweghị mmetụta mgbochi ọ bụla na ọwa ion na renin. Mmetụta igbochi na kininase II, nke nwere mbelata bradykinin, adịghị anọ.

Kedu ọnọdụ ọbara m kwesịrị ị takeụ?

Iji belata ọbara mgbali, a na-enye Telmista 40 mg kwa ụbọchị. N'ime ụfọdụ ndị ọrịa, ọbụlagodi ọgwụ kwa ụbọchị nke 20 mg, enwere ike nweta nsonaazụ zuru oke. Ọ bụrụ na emebeghi mgbaru ọsọ ọbara mgbali elu, dọkịta nwere ike ịbawanye ọgwụ ahụ ruo 80 mg kwa ụbọchị.

Enwere ike ịnye ọgwụ ahụ na mgbakwunye na onye na-enye mmiri ara ehi sitere na otu thiazide (dịka ọmụmaatụ, hydrochlorothiazide). Tupu mmụba ọ bụla, dọkịta ahụ ga-eche izu anọ ma ọ bụ asatọ, ebe ọ bụ na mgbe ahụ gosipụtara mmetụta kachasị elu nke ọgwụ ahụ.

Iji gbochie mmebi vaskụla na ọnọdụ dịbu, ọgwụ a tụrụ aro bụ 80 mg nke telmisartan otu ugboro n'ụbọchị. Na mbido ọgwụgwọ, a na-atụ aro ka ịbanye n'ọbara ugboro ugboro. Ọ bụrụ na ọ dị mkpa, dọkịta ahụ ga-ahazi usoro ọgwụgwọ iji mezuo ọbara mgbali elu. A na-atụ aro mbadamba nkume iji mmiri mmiri ma ọ bụ n'agbanyeghị nri nri.

Telmista H80

A na-ewere ọgwụ ọnụ 1 oge / ụbọchị, n'agbanyeghị nri. Mbadamba ga-eji ntakịrị mmiri hichaa ya.

Enwere ike ịkọwa Telmista H80 maka ndị ọrịa bụ ndị iji telmisartan na ọgwụ nke 80 mg anaghị ebute nchịkwa zuru oke nke ọbara mgbali.

Gụọ akwukwo a: Lasix: mbadamba 40 mg na injections

Tupu ịmalite ọgwụgwọ, ị ga-eme ọgwụ nhọrọ megide telmisartan monotherapy. Ọ bụrụ na ọ dị mkpa, ịnwere ike ịgbanwe site na monotherapy na telmisartan na ọgwụgwọ na Telmista H80.

Ọ bụrụ na ọ dị mkpa, enwere ike ịcribedụ ọgwụ a na ọgwụ ọzọ.

Nsonaazụ

Ojiji nke Telmista, yana ọgwụ ndị ọzọ antihypertensive, nwere ike ibute nsonaazụ ọjọọ dị iche iche maka ahụ.

N'ime mmetụta dị iche iche, ntuziaka maka ojiji ịmata ọdịiche ndị a:

imebi akụrụ na usoro urinary,
ọkụ na-efe efe na ọrịa ịba,
ụkwara, ọnya na-efe efe nke akụkụ elu na nke akụkụ okuku ume na ume, mkpụmkpụ ume,
enweghi ike nke ngwa anya,
ọgba aghara nke obi, nke tachycardia na bradycardia pụtara,
nsogbu nke afọ na eriri afọ, nke afọ ọsịsa gosipụtara site na afọ ọsịsa, ọgbụgbọ, syndromes mgbu na mgbu.
nkụda mmụọ, ọgba aghara ụra, ike ọgwụgwụ,
hypersensitivity na mmetụta dị iche iche dị na mpụga, nke na-egosipụta onwe ya n'ụdị akpụkpọ itching na urticaria, anaphylactic shock and hyperhidrosis,
anaemia na nsogbu nke sepsis na-egbu egbu.
ihe adighi nma nke ihe omumu nke ihe omumu banyere ihe banyere ihe banyere ihe ndia, nke gosiputara na oke uric acid, creatinine n'ime obara, hypoglycemia na mbelata nke obara.

Otu mmetụta ndị a ọ bụla nwere ike ime naanị ma ọ bụ naanị ya na ndị ọzọ. Maka mgbaàmà na-enyo enyo, a chọrọ nlekọta ahụike ozugbo iji dozie usoro ọgwụgwọ ahụ.

Childrenmụaka, n’oge ime na lactation

Emebeghi nchekwa na ịdị irè nke ojiji nke telmisartan na ọrịa ụmụaka, yabụ, ekwesighi inye mbadamba ụrọ Telmista 40 mg, 80 mg na 20 mg maka ụmụaka na ndị nọ n’agbata afọ 18.

Dabere na ntuziaka ahụ, a na-egbochi Telmista n'oge afọ ime. N'ihe banyere nchọpụta afọ ime, ọgwụ a ga-akwụsị ozugbo.

Ebe o nweghi ihe omuma banyere n’ime uzo nke telmisartan n’ime mmiri ara, ogwu a na - enye ogwu n’oge nri.