Mmetụta nke Bayeta na-arịa ọrịa shuga

Ebe ọ bụ na isiokwu banyere ọgwụ ahụ pụtara na weebụsaịtị anyị "Baeta", nke a na-eji n'ịgwọ ụdị ọrịa shuga 2, ihe karịrị otu afọ agafeela. N'oge a, “Baeta” nwetara ụfọdụ ihe ama ama na mpaghara nke mba ndị bụbu USSR ma nwee ohere ịnweta ndị ọrịa mamịrị.

Taa, anyị ga-ekwu maka ọgwụ a n'ụzọ zuru ezu karị, tụlee akụkọ banyere ihe mepụtara ya iji ghọta etu o si emetụta ahụ nke ndị ọrịa mamịrị, otu o si dị iche na ọgwụ ndị ọzọ, otu ọ ga - esi baa uru na ihe ọ nwere ike ịkpata.

Na North America, ụdị nnụnụ pụrụ iche na-adị ndụ, nke na-eri nri naanị ugboro 3-4 kwa afọ. N'otu oge ahụ, ha na-eri nri buru oke ibu - ihe ruru otu ụzọ n'ụzọ atọ nke izu ha niile.

Paya ntị na ihe ijuanya anụ ọhịa a, ndị ọkà mmụta sayensị America achọpụtala na mmiri nke anụmanụ a nwere ihe dị n'ime ya exendin. Mgbe ogwe osisi na-abanye na ngwangwa nri na sistem exendin na-enye aka na nkesa nri nri ka oge na-aga. Nke ahụ bụ, a na-etinye nri nwayọ nwayọ, nke mere na a na-ebute ụdị nri dị etu a.

Site na mgbanwe nke mmiri nke anụmanụ a sirila banye, ọgwụ Bayeta pụtara, ya na ihe nwere ike igbapu.
Pezọ ịgwọ ọrịa ụdị ọgwụgwọ shuga dị afọ 2 bụ na ọ na - enyere aka belata ahụ ahụ onye ọrịa. Ezie na ọtụtụ ọgwụ eji maka otu nzube na-eduga ndị ọzọ nsonaazụ.

Ọ bụrụ n’ilelee na otu n’ime ihe kpatara ọrịa a buru oke ibu na oke ibu, yabụ ojiji ụdị ọrịa shuga 2 enwere ike ịtụle dị ka ihe ngwọta maka nsogbu abụọ n'otu oge.

Dabere na nyocha na akwụkwọ dị iche iche, a na-eji byte mee ihe ugboro abụọ n'ụbọchị. N'okwu a, a naghị eji insulin eme ihe. Mana ụdị shuga ọgwụgwọ 2 Dakọtara na iji ọgwụ ụfọdụ ndị ọzọ.
A na-ewebata iwebata ọgwụ ọgwụ n'apata ụkwụ, aka ma ọ bụ n'afọ, n'ime abụba dị n'okpuru. A na-eji mkpịsị sirinji mgbe niile eme ihe a.

Nanị ike enwere ike iji ọgwụ a gwọọ ọrịa shuga. A naghị atụ aro ya iji ọgwụ a na ọnụnọ ọrịa dịka ọrịa ketocidosis nke ọrịa mamịrị, ọdịda akụrụ, ọrịa eriri afọ dị iche iche, yana ịba ụba maka akụkụ dị iche iche nke ọgwụ.

Enweghị ike ịkọwa Bayeta ụmụaka gbara afọ 18, jiri oge atụrụ ime na oge inye nwa ara.

Enwere nkuzi.

A na-enye ọgwụ ahụ ruo otu awa tupu nri, ugboro 2 n'ụbọchị. Usoro ọgwụgwọ, mbelata ya ma ọ bụ ịrị elu ya ka a na-atụ aro ka gị na dibịa bekee lelee ya.

Nweghị ike iji ụlọ ịsa ahụ ma ọ bụrụ na ngwọta ya dị urukpuru, a na-ahụ ihe dị iche iche na ya ma ọ bụ nwee agba na-enyo enyo. A naghị atụ aro ya ka ị jiri ya ozugbo ị risịrị nri. Achọghị nchịkwa nke intramuscular na intraven of a byte solution.

Mgbe ị na-eji ọgwụ nje dị iche iche, ekwesịrị ị were ha otu awa tupu nchịkwa nke ọgwụ ọgwụ byte.

Tupu ị .ụ ọgwụ ahụ Baeta maka ịgwọ ụdị ọrịa shuga 2, ị ga-agakwuru dọkịta!

International Nonproprietary Aha

INN Bayeta - Exenatide.

Baeta bụ ihe nnọchianya hypoglycemic nke e mere maka ịgwọ ụdị ọrịa shuga II, ọgwụ na-arụ ọrụ nke ukwuu.

Ọgwụ a bụ nke otu ọgwụ ọgwụ nke ndị na - eme ihe hypoglycemic sịntetik nke chọrọ iji gwọọ ọrịa shuga na - akpata ọrịa shuga mellitus, ma nwee akara ATX nke A10X.

Weputara udi ya na ihe mebere ya

Ogwu a di n ’udidi ogwu ogwu ogwu nke eji eji subcutaneous management. Ọ bụ mmiri doro anya, enweghị agba na isi. Ihe eji arụ ọrụ ya exenatide nwere ntụgharị nke 250 μg kwa 1 ml nke ihe ngwọta. A na-arụ ọrụ nke ihe mgbaze ahụ site na mmiri injection, na-anọchite anya inyeaka ahụ bụ metacresol, sodium acetate trihydrate, acetic acid, na mannitol (mmonye E421).

A na-awụnye ihe ngwọta nke 1.2 ma ọ bụ 2.4 ml n'ime katrized iko, a na-etinye nke ọ bụla na mkpịsị mkpụrụ sirinji - analogue nke inulinor insulin. Nkwakọ ngwaahịa katọn. Enwere naanị sirinji 1 na ọgwụ na igbe.

Enwere nkwanye nkwado na-adịgide adịgide dịnụ n'ụdị ntụ ntụ maka ịkwadebe ngwakọta nkwusioru. A na-ejikwa mmiri mmiri na - apụta. A na-awụnye ntụ ntụ (2 mg) n'ime katriiki nke etinyebere na pen sirinji. Ngwa ahụ gụnyere ihe mgbaze na ntụziaka.

Bayeta bụ katọn klas nke nwere ọgwụ nkwụ ụgwọ maka nchịkwa subcutaneous, nke etinyere na ya.

Omume ọgwụ

A na-enye mmetụta nke ọgwụ ahụ site na ọrụ nke exenatide (exendin-4).

Ihe mejuputara ogige a bu ihe eji amino peptide nke nwere ihe 39 amino acid nwere.

Ihe a bụ analoglucagon bụ ahaziri arụ ọrụ - homonụ peptide nke klas nke emepụtara na ahụ mmadụ, nke a na-akpọkwa glucagon-like peptide-1, ma ọ bụ GLP-1.

A na-emepụta incretins site na sel nke pancreas na eriri afọ mgbe nri gachara. Ọrụ ha bụ ịmalite ịmịnye insulin. N'ihi myirịta ya na ihe homonụ ndị a, exenatide nwere otu mmetụta ahụ n'ahụ. Arụ dị ka ihe dịka GLP-1 mimetic, ọ na-egosipụta njirimara ọgwụgwọ ndị a:

• na-eme ka ntọhapụ nke insulin site na mkpụrụ ndụ reat-pancreatic na-abawanye na ịbawanye uru glucose plasma,
• na-ebelata glucagon zoro ezo gabigara ókè, na-enweghị inye nsogbu nzaghachi hypoglycemia,
• na-egbochi ọrụ nke afọ, na-eme ka ọ ghara ịdịkwa,
• na-achịkwa agụụ
• na-ebelata oke nri a na-eri,
• na-akwalite ibu ibu.

Ntụziaka Byetta - aplikace Kedu ụdị ọrịa shuga 2 n'ụdị dị mfe

Ọrịa shuga 2dị nke abụọ, ọrụ reat-sel na-eme ka ọ daa ọrụ, na-eme ka mmadụ nwekwuo insulin. Exenatide na-emetụta ma usoro insulin insulin abụọ. Mana n'otu oge ahụ, ike nke ọrụ sel-abuo nke ọ malitere malitere na-ebelata mgbanye glucose. Iri insulin na-akwụsị mgbe oge nchịkọta glycemic na-alaghachi na nkịtị. Ya mere, iwebata ọgwụ a na-ajụ ajụjụ na-ebelata ohere nke ịmalite hypoglycemia.

Ọmụmụ ihe omimi gosipụtara na ụdị ọgwụgwọ a na-enye ohere maka nchịkwa shuga ọbara dị mma n'ebe ndị ọrịa nwere ụdị shuga nke 2 nọ.

Mlọ ọgwụ

Mgbe nchịkwa Baeta nọchara n'ụdị ọgwụ nro subcutaneous, ọgwụ bidoro banye n'ọbara, rute n'ọtụtụ izu ike n'ihe dị ka elekere abụọ.

Mkpokọta mkpokọta nke exenatide na-abawanye na nha ka usoro natara na oke nke 5-10 μg.

Ọgwụ ọgwụ Baeta ruru n'ọkwa ya zuru oke n'ọbara awa 2 mgbe nchịkwa subcutaneous gasịrị, ọ na-ewepụ ya kpamkpam n'ime ahụ n'ime awa iri.

A na-emegharị ọgwụ ahụ site na akụrụngwa gbasara akụrụ, enzymes proteolytic na-etinye aka na metabolization ya. Ọ na-ewe ihe dị ka awa 5 iji wepụ ọgwụ dị ukwuu n'ahụ ya, n'agbanyeghị usoro ị .ụ ya. Ihicha ahụ zuru oke na-ewe awa iri.

Ihe ngosi maka ojiji

E gosipụtara ọgwụ a maka mgbazi glycemic zuru oke n'ụdị ọrịa shuga na-adabere na ọrịa shuga. Enwere ike iji Byetu mee ihe dị ka ọgwụ hypoglycemic maka monotherapy. Mmetụta ọgwụ dị otú a dị irè ma ọ bụrụ na a na-agbaso nri kwesịrị ekwesị ma na-eme mmega ahụ oge niile.

Enwere ike itinye ọgwụ a na usoro a jikọtara ọnụ na arụmọrụ zuru oke nke ọgwụgwọ ya na ndị ọrụ antiglycemic ndị ọzọ. Ọtụtụ ọgwụ ọgwụ na Bayeta na-anabata:

1. Nchịkwa nke Sulfonylurea (PSM) na Metformin.
2. Metformin na Thiazolidinedione.
3. PSM nwere Thiazolidinedione na Metformin.

Atụmatụ ndị dị otú a na-eduga n'ọbara shuga obubu ọnụ ma mgbe ha risịrị nri, yana glycemic haemoglobin, nke na-eme ka njikwa glycemic na-emetụta ndị ọrịa.

Edebere Bayeta maka mmezi glycemic zuru oke, enwere ike iji ya maka monotherapy.

Ihe ngbanwe

Enweghị ike iji ọgwụ ahụ maka ọrịa shuga 1. Ihe mgbochi ndi ozo:

• mụbawanye ikike ịba mba,
• anabataghị enyemaka ndị ọzọ,
• ketoacidosis
• mmebi nke usoro nri, yana mbelata nke ọrụ ngo nke akwara afọ
• nye nwa ara ma obu ime
• nnukwu nsogbu gbasara akwara
• afọ ruo afọ 18.

Breastu ara bụ otu n’ime ihe ndị eji egbochi ọgwụ Bayet.

Etu esi ewere bayetu?

Dọkịta na-ahụ maka ịde ọgwụ ahụ, ikpebi usoro kachasị mma yana nyochaa ọnọdụ onye ọrịa na-arịa ọrịa shuga. A na-akwadosi ike ka ị zere ị fromụ ọgwụ.

A na-elekọta ụmụ irighiri ahụ n'okpuru anụ ahụ n'ime brachial, femoral ma ọ bụ mpaghara abdominal. Ebe ogwu ogwu ogwu n’enyeghi aru ya.

Na mbu, otu usoro onunu ogwu bu 0.005 mg (5 μg). A na-enye ọgwụ mgbochi tupu nri ụtụtụ na nri abalị. Oghere na-adị nwa oge n'etiti iwebata ọgwụ na mbido nri agaghị agafe elekere 1.

N'agbata nri isi, nke jikọtara ya na iji ọgwụ, ọ dịkarịa ala awa 6 kwesịrị ịgafe.

Mgbe otu ọnwa gachara ọgwụgwọ, a nwere ike okpukpu abụọ nke otu ọgwụ. Ọgwụ ịgba agbasaghị anaghị eme ka mmụba ọ bụla dị na ọgwụ ọgwụ ga-esochi. Mgbe i richara Bayetu, ekwesighi ịfu ọnụ.

Site n'iji ọgwụ ọgwụ yiri ya mee ihe na nkwadebe sulfonylurea, dọkịta nwere ike belata usoro nke ikpeazụ n'ihi ikike mmepe nke mmeghachi omume hypoglycemic. Nchikota na Thiazolidinedione na / ma obu Metformin achoghi ngbanwe nke usoro ogwu a.

Nsonaazụ

Mmeghachi omume ọjọọ nke exenatide nwere obere ogo na anaghị achọ ịkwụsị ọgwụ ahụ (yana ihe ndị dị ụkọ). Ọtụtụ mgbe, na ọkwa mbụ nke ọgwụgwọ na Bayeta na usoro nke 5 mg ma ọ bụ 10 mg, ọgbụgba na-apụta, nke na-apụ n'anya n'onwe ya ma ọ bụ mgbe ọ dozigharịrị ọgwụ ahụ.

Nausea bụ ihe dị njọ na mmeghachi omume nke ọgwụ Bayet, gosipụtara ọtụtụ mgbe na usoro ọgwụgwọ mbụ.

Ọkpụkpụ afọ

Ọtụtụ mgbe, ndị ọrịa na-enwe nsogbu mgbari. Ndị ọrịa na-eme mkpesa nke ọgbụgbọ, enweghị agụụ, ọgbụgbọ, dyspepsia, mgbu n'ime afọ. Nzipu puru iche, ọdịdị nke nbughari, ire ure, ntachi, imebi ihe uto. Otutu ikpe nke akwara nke achoputala achoputala ya.

Sistemụ akwara Central

Ọtụtụ mgbe ndị ọrịa na-enwe migraine. Obi nwere ike ịna-ama ha ura ma obu inwe ura nke ubochi nile.

Migraines bụ ihe ndị ọzọ na-ebutekarị ojiji nke ọgwụ Bayet site na sistemụ akwara.
N'ihi iji ọgwụ Bayeta na-eme, ndị ọrịa nwere ike ịmị nkụ.
Mmegide nke ụra ehihie bụ ihe ga - ekwe omume n'akụkụ nke iji Byeta.

Na anụahụ

N'ebe a na-agba ntụtụ, ọ nwere ike ịhụ ihe ịrịba ama mmekpa ahụ.

Mmeghachi omume Allergic nwere ike n'ụdị rashes skin, itching, redness, swelling. Ana anaghị ahụkarị ngosipụta anaphylactic.

Ọkpụkpọ isi awọ bụ ihe nfụkasị ahụ na-emetụta ọgwụ nke Bayet.

Ntụziaka pụrụ iche

Ọ bụrụ na agbanwee agba, nghọta ma ọ bụ ịdị n'otu mmiri ọgwụ injection gbanwere, enweghị ike iji ya. Should ga-agbaso usoro nlekọta ọgwụ a tụrụ aro ya. A naghị enye ọgwụ irigide intramuscularly ma ọ bụ intraven.

Mbelata agụụ ma ọ bụ ịbelata ọrịa abụghị ihe ngosipụta maka ịkwụsị ọgwụ, mgbanwe n ’ụzọ ọ ga-esi eme ya na ugboro ole ojiji ya.

Na nzaghachi na iwebata exenatide, enwere ike imepụta ọgwụ mgbochi anụ ahụ. Nke a anaghị emetụta mkpughe nke mgbaàmà akụkụ.

Jiri na agadi

Aclọ ọgwụ ọgwụ anaghị agbatị afọ ole ndị ọrịa dị. Ya mere, ekwesighi ime mgbanwe maka usoro ọgwụgwọ maka ndị agadi.

Okenye abughi ihe contraindication maka ojiji nke ọgwụ Bayet, anyi achoghi imeghari etu ogwu si eme ya.

Jiri maka ọrụ imeju na-arụ ọrụ

N'ihi eziokwu ahụ bụ na ibu dị arọ maka iwepu exenatide na-adakwasị akụrụ, malfunctions nke imeju ma ọ bụ eriri afọ abụghị ihe mgbochi maka iji ọgwụ ahụ emechilakwa mmachi.

Ọdịda nke imeju ma ọ bụ eriri afọ abụghị ihe mgbochi maka iji ọgwụ.

Do Overụbiga mmanya ókè nke Byeta

Nnukwu ike nke doses na-atụ aro nke exenatide na-eduga hypoglycemia. N'okwu a, a chọrọ ntụtụ ma ọ bụ ntapu glucose. Mgbaàmà nke ịdoụbiga mmanya ókè:

• nsogbu nke ọgbụgbọ
• vomiting
• plasma glucose dị ala
• pallor nke intgument,
• akpata oyi
• isi ọwụwa
• ọsụsọ
• arrhythmia,
• ụjọ
• mmụba ọbara mgbali:
• ịma jijiji.

Arrhythmia bụ otu n'ime ihe ngosipụta nke ịdoụbiga mmanya ókè nke Bayet.

Mmekọrịta na ọgwụ ndị ọzọ

Ejikọtara ngwakọta ahụ na ọgwụ ndị ọzọ siri ike na sirinji 1.

Ikwesiri iburu n’uche nke afo n’okpuru oru nke exenatide mgbe ị na-a drugsụ ọgwụ n’ime, n’ihi na enwere ike belata ogo ogo ihe na mmịpụta. Ekwesịrị ị nweta ụdị ego a ogologo oge tupu iwebata Byeta, obere oge dị otu awa. Ọ bụrụ na ọgwụ kwesịrị iji nri rijuo ya, mgbe ahụ ọ ga-abụ nri anaghị ejikọ ya na ọgwụ ịgba ọgwụ hypoglycemic a.

A ga-emerịrị ndị na-egbochi proton mgbapụta awa 4 mgbe ịgba ọgwụ ma ọ bụ otu awa tupu ya.

Site na ojiji a na-eji warfarin ma obu ihe ndi ozo eji eme ihe, ihe ndi prothrombin ga - ekwe omume. Ya mere, ekwesịrị ịchịkwa coagulation ọbara.

Agbanye na ojiji nke Bajeta juputara na ogwu nke na egbochi oria HMG-CoA, anaghị akpata mgbanwe dị egwu na oke nke ọbara, a na-atụ aro ka ị nyochaa akara cholesterol.

Nchikota nke ogwu ajuju na Lisinopril adighi eme ka mgbanwe di ka obara mgbali elu na onye ọrịa.

Bgụnye inje inwere nke Bajeta yana mgbochi ogwu a na-ekwu okwu adighi acho mgbanwe mgbanwe onunu ogwu.

Ọ dịghị mkpa iji leruo oge ọ bụla pụrụ iche n'etiti inyections Bayeta na ị takingụ ọgwụ - usoro nke sulfanylurea.

Site na njikọta / njikọta Bayeta na Warfarin, ọ dị mkpa ijikwa ịmịnye ọbara.

Mmanya ndakọrịta

Ọ bụ ihe na-adịghị oke mma ị consumeụ mmanya ma ọ bụ ọgwụ maka mmanya n'oge ọgwụgwọ.

Enwere naanị ụdị analogues 2 zuru ezu - Exenatide na Baeta Long. Ndị nnọchianya hypoglycemic ndị a nwere mmetụta yiri ya:

Generic Baeta - Bydureon (Bydureon).

Victoza bụ ihe nnọchianya hypoglycemic nke nwere ụdị mmetụta ahụ na Bayeta.

Exbọchị mmebi

N’ụdị mbụ ya, a na-echekwa ọgwụ ahụ maka afọ 2. Mgbe ịmepe ngwugwu ahụ, a ga-eji ya n’ime ụbọchị iri atọ.

Ndụ nchekwa nke ọgwụ Bayeta bụ afọ 2 n'ụdị mbụ ya na ụbọchị iri atọ mgbe emepechara ngwugwu ahụ.

Emeputa

Mba ekwuputara site na mba a bụ Great Britain. Agbanyeghị, ụlọ ọrụ ndị na-ahụ maka ọgwụ ahụ bụ ụlọ ọrụ ọgwụ India na Macleods Pharmaceuticals Ltd.

Alla, 29 afọ, Stavropol.

M zụta mama Baitu. Dị ọnụ, ma adaba iji. Na mbụ, mama m mere mkpesa na ọ bụ ọgbụgbọ, mana n'oge na-adịghị anya ọ kwụsịrị.Sugar kwụsiri, yabụ anyị ga-aga n’ihu ị .ụ ọgwụ ahụ.

Veronika, 34 afọ Danilo.

Mgbe m gụghachiri ntuziaka ahụ, enwere m nkụda mmụọ site na nsonaazụ ndị ọ bụla. Mgbe ogwu ogbugba m na-arịa ọrịa. Wasjọ na-atụ m ọbụna inye ọgwụ ga-esochi ya. Ma di m kwuru na m ghọgburu onwe m. O kwuru eziokwu. Insa mmiri na-esote abụkwaghị ihe mgbu. Dọkịta ahụ kwuru na a gaghị ekewa usoro ọgwụgwọ ahụ, ma emesịa meekwuo ya. Ugbu a, ọ naghịzi arịa ọrịa, naanị mgbe ụfọdụ enwere nsogbu na afọ.

Olga, onye gbara afọ 51, bụ obodo Azov.

Amalitere m iji ọgwụ ahụ nyere Metformin aka. O riri nri site na ụbọchị mbụ site na ike - agụụ ya fọrọ nke nta ka ọ gwụ. Mgbe ahụ ahụ nwetara. Akụkụ ndị ahụ pere mpe, ma agụụ gụghachite. Ugbu a ọ bụ ihe doro anya ihe mere na Amerịkà Bayetu ka edepụtara maka ndị chọrọ ifelata.

Ngwakọta na ụdị ntọhapụ

n’ime mkpụrụ ego sirinji nke nwere mpempe akwụkwọ nke 1.2 ma ọ bụ 2.4 ml, n’ime mkpọ kaadiboodu 1 mkpụrụ mịrị amị.

Mlọ ọgwụ

Exenatide (Exendin-4) bụ ọgwụ incretin ma bụrụ amidopeptide 39-amino acid. Ihe ndị metụtara, dị ka gluptagon-dị ka peptide-1 (GLP-1), na-eme ka insulin na-adabere na glucose dị mma, na-arụ ọrụ beta cell, na-ebelata glucagon nke ukwuu na-ebelata ma belata gastric empt mgbe ha batara n'ọbara ọbara n'ozuzu ya na eriri afọ. Exenatide bụ ọgwụ dị egwu nke na-eme ka mmiri ọgwụ insulin na-emetụta glucose ma nweekwa mmetụta hypoglycemic dị iche iche maka incretins, nke na-eme ka nchịkwa glycemic na ndị ọrịa nwere ụdị nke abụọ.

Usoro amino acid nke exenatide dabara na usoro nke mmadụ GLP-1, n'ihi nke ọ na-ejikọ ma na-akpali ndị na-anabata GLP-1 n'ime mmadụ, nke na-eduga n'ịba ụba njikọta glucose na izochi insulin site na mkpụrụ ndụ beta nke pancreatic na ntinye nke cyclic adenosine monophosphate (AMP) ma ọ bụ / / ụzọ mgbaàmà ndị ọzọ intracellular. Exenatide na-akpali ntọhapụ nke insulin site na mkpụrụ ndụ beta na ọnụnọ nke glucose dị elu.

Exenatide dị iche n'ụdị kemịkalụ na ihe ọgwụ na-arụ na insulin, n'ụkpụrụ sulfonylurea, usoro D-phenylalanine na meglitinides, biguanides, thiazolidinediones na alfa-glucosidase inhibitors.

Exenatide na-eme ka nchịkwa glycemic dịkwuo mma na ndị ọrịa nwere ọrịa shuga nke 2 n'ihi usoro ndị edepụtara n'okpuru.

Na ọnọdụ hyperglycemic, exenatide na-eme ka mmiri ọgwụ insulin na-egbochi glucose na-emetụta ya. Ihe nzuzo insulin a na-akwụsị ka ịba ụba nke glucose n'ọbara na-ebelata ka ọ na-erukwa ihe kwesịrị ekwesị, si otú a belata ihe egwu nwere ike ịrịa hypoglycemia.

Ihe nzuzo insulin n'oge nkeji iri mbụ, nke a maara dị ka “ngalaba mbụ nke nnabata insulin” enweghị ndị ọrịa nwere ọrịa shuga nke 2. Agbanyeghị, mfu nke ngalaba mbụ nke nzaghachi insulin bụ nkwarụ n'oge nke mkpụrụ ndụ beta na ọrịa shuga nke 2. na-eweghachi ma ọ bụ na-akwadowanye ma akụkụ nke mbụ na nke abụọ nke nzaghachi insulin na ndị ọrịa nwere ụdị shuga 2.

N'ime ndị ọrịa nwere ụdị ọrịa shuga 2 nke ọrịa hyperglycemia, nlekọta nke exenatide na-egbochi oke glucagon. Agbanyeghị, exenatide anaghị egbochi nzaghachi glucagon nkịtị na hypoglycemia.

E gosipụtara na nchịkwa nke exenatide na-eduga n'inwe agụụ na mbelata iri nri, na-egbochi mot ọnụ nke afọ, nke na-eduga n'ịbelata ọfụma.

N'ime ndị ọrịa nwere ụdị ọrịa shuga mellitus nke 2, ọgwụgwọ exenatide na mgbakwunye na nhazi nke metformin na / ma ọ bụ sulfonylurea na-eduga ná mbelata ọbara glucose ọbara, postprandial ọbara glucose, na glycosylated hemoglobin index (HbA1c), si otú a na-emeziwanye njikwa glycemic na ndị ọrịa a.

Usoro onunu ogwu na nhazi

S / c n’apata ụkwụ, n’ime afọ, ma ọ bụ n’apata ụkwụ.

Ọgwụ nke mbụ bụ 5 mcg, nke a na-elekọta ugboro 2 / ụbọchị n'oge ọ bụla n'oge nkeji 60 tupu nri ụtụtụ na nke mgbede. Emela ọgwụ ahụ mgbe ị risịrị nri. Ọ bụrụ n ’ị isụ ọgwụ ọgwụ ahụ na-efu, ọgwụgwọ ga-aga n’ihu n’ebughi ịgbanwe ogwu ahụ.

Otu ọnwa mgbe ịmalite ọgwụgwọ, ị canụ ọgwụ nke ọgwụ ahụ nwere ike ịbawanye 10 mcg ugboro abụọ / ụbọchị.

Mgbe ejikọtara ya na metformin, thiazolidinedione, ma ọ bụ na ọgwụ ndị a jikọtara ọnụ, a gaghị agbanwe usoro izizi nke metformin na / ma ọ bụ thiazolidinedione. N'ihe banyere njikọta nke Bayeta ® yana usoro sulfonylurea, enwere ike ịbelata mbelata nke ụdị sulfonylurea iji belata ihe egwu hypoglycemia.

Usoro onunu ogwu na uzo nke ochichi ogwu BAETA

A na-eme ọgwụ mgbochi ọgwụ s / c na afọ, apata ụkwụ, ubu.

Ọgwụ nke mbụ bụ 5 mcg, nke a na-ahụ ugboro abụọ n'ụbọchị, maka nkeji 60 tupu nri ụtụtụ na nri abalị. Mgbe ị risịrị nri, a naghị atụ aro ọgwụ ahụ. Ọ bụrụ nleghara ịgba ntụtụ, emegharịla usoro okpukpu abụọ n'oge nlekọta ọzọ.

Usoro ịba ụba na-abawanye na ọnwa ruo 10 mcg ugboro abụọ n'ụbọchị.

Ọrịa shuga 2dị nke abụọ: monotherapy ma ọ bụ mgbakwunye ọgwụgwọ na metformin, sulfonylurea na ọgwụ thiazolidinedione na enweghị nchịkwa glycemic.