Hainemox (Hinemox) > Ọgwụgwọ na mgbochi

Mbadamba nkume ndị ahụ, a na-eji ihe mkpuchi na-acha ọbara ọbara na-acha ọbara ọbara, bụ oval, biconvex, nwere ọkwa, na oge ezumike - ọtụtụ site na-acha ọcha na-acha odo odo na agba aja aja.

Taabụ 1
moxifloxacin hydrochloride	436.3 mg
nke kwekọrọ na ọdịnaya moxifloxacin	400 mg

Ndị pụrụ iche: ọka ọka - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, talc nke dị ọcha - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl stachi - 20 mg, ihe na-enye silicon dioxide anhydrous - 3.5 mg, croscarmellose sodium - 6.5 mg microcrystalline cellulose - 130.7 mg.

Ihe mejupụtara Shell: Opadry white 85G58997 Makc-Colorcon (mmanya polyvinyl, titanium dioxide, talc, macrogol 3000, lecithin (soy)) - 17.32 mg, iron oxide uhie - 0.68 mg.

5 pcs. - blisters (1) - ngwugwu nke kaadiboodu.
7 pcs - blisters (1) - ngwugwu nke kaadiboodu.
10 PC. - blisters (1) - ngwugwu nke kaadiboodu.
5 pcs. - blisters (2) - ngwugwu nke kaadiboodu.
7 pcs - blisters (2) - ngwugwu nke kaadiboodu.
10 PC. - blisters (2) - ngwugwu nke kaadiboodu.
5 pcs. - blisters (10) - ngwugwu nke kaadiboodu.
7 pcs - blisters (10) - ngwugwu nke kaadiboodu.
10 PC. - blisters (10) - ngwugwu nke kaadiboodu.
100 pcs - akpa (1) (maka ụlọ ọgwụ) - Mkpọ plastik.
500 PC - akpa (1) (maka ụlọ ọgwụ) - Mkpọ plastik.
1000 PC - akpa (1) (maka ụlọ ọgwụ) - Mkpọ plastik.

Omume ọgwụ

Onye na-ahụ maka ọgwụ mgbochi site na otu fluoroquinolones, na-eme nje. Ọ na - arụ ọrụ na - emegide micromgangan gram na-adịghị mma na gram na - adịghị mma, anaerobic, acid na - eguzogide ọgwụ na atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Ọ dị irè megide ụdị nje na-eguzogide ọgwụ beta-lactams na macrolides. Ọ na - arụ ọrụ megide ọtụtụ ụdị microorganisms: gram-nke oma - Staphylococcus aureus (gụnyere ụdị adịghị emetụta methicillin), pulcoeptoptoccccus (gụnyere nje ndị na - eguzogide penisilini na macrolides), Streptococcus pyogenes (otu A), gram-negative - Haemophilus influenzae ( na nje ndị na-abụghị beta-lactamase), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (gụnyere ma ndị na-anaghị emepụta beta na-abụghị beta-lactamase), Escherichia coli, Enterobacter cloacae, Chlamydia na oyi baa. Dika ihe omumu banyere vitro siri di, obu ezie na umu ihe ndi ahuru n’okpuru ebe a bu ihe banyere moxifloxacin, agbanyeghi, o dobeghi nchekwa ya na odi nma n’imeso oria. Gram-mma ntule: streptococcus milleri, streptococcus mitior, streptococcus agalactiae, streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (gụnyere nje, methicillin mwute), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Mkpụrụ ndụ na-adịghị mma: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter nkezaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. A na-ahụkarị microorganisms: Legionella pneumophila, Caxiella burnettii.

Nkanka topoisomerases nke II na nke anọ, enzymes na-achịkwa njirimara topological nke DNA, ma na-etinye aka na nnomi, ndozi, na ntụgharị DNA. Mmetụta nke moxifloxacin na-adabere na ntinye uche ya na ọbara na anụ ahụ. Obere ihe ncheta nke nje bacteria na-adịghị iche na nke kacha nta nke inhibitory.

Developmentzọ mmepe nrụgide, inactivating penicillins, cephalosporins, aminoglycosides, macrolides na tetracyclines, anaghị emetụta ọrụ antibacterial nke moxifloxacin. Enweghị nguzogide n'etiti moxifloxacin na ọgwụ ndị a. Achọpụtaghị usoro mmepe mbido plasmid. Ọnọdụ nguzogide n'ozuzu ya dị ala. Na nyocha nke vitro egosiwo na iguzogide moxifloxacin na-amalite nwayọ nwayọ n'ihi nsonye na-agbanwe oge. Site na ikpughe microorganisms ugboro ugboro na moxifloxacin na subminimal inhibitory concentrations, ihe ngosi BMD na-abawanye ntakịrị. A na-ahụta nguzogide nkwụghachi n'etiti ọgwụ ọjọọ sitere na otu fluoroquinolone. Agbanyeghị, ụfọdụ microorganisms gram-positive na anaerobic na-eguzogide fluoroquinolones ndị ọzọ na-emetụta moxifloxacin.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-etinye moxifloxacin ngwa ngwa ma ọ fọdụ nke ọma. Mgbe otu ọgwụ moxifloxacin na-a atụ n’arọ nke ọ̀tụ̀tụ̀ 400 mg C max n’ọbara na-enweta n’ime awa 0,5-4 ọ bụrụ 3.1 mg / L

Mgbe otu mkpụrụ ọgwụ na ọkara nke mg mg maka 1 h, a na-enweta C max na njedebe nke infusion ya bụ 4.1 mg / l, nke kwekọrọ na mmụba nke ihe dị ka 26% ma e jiri ya gosipụta uru a na-egosi mgbe a na-ekwu ya. N'ihe banyere otutu infusus IV na ọgwụ nke 400 mg maka elekere 1, C max dịgasị na oke site na 4.1 mg / l ruo 5.9 mg / l. Nkezi C ss nke 4,4 mg / L ruru na njedebe nke ọgbụgba ahụ.

Ezigbo bioavailability dị ihe dịka 91%.

The pharmacokinetics nke moxifloxacin mgbe ewere ya na otu onunu si 50 mg ruo 1200 mg, yana na 600 mg / ụbọchị maka ụbọchị 10, bụ ahịrị.

Ekwadoro steeti etolite n’ime ụbọchị 3.

Indtinye aka na-edozi ọbara (ọkachasị albumin) bụ ihe dịka 45%.

A na - ekesa Moxifloxacin ngwa ngwa n’akwara na akwara. V d bụ ihe dịka 2 l / n'arọ.

Nnukwu uche nke moxifloxacin, karịa ndị nọ na plasma, ka etinyere n’akwara umeji (gụnyere alveolar macrophages), na akpụkpọ ahụ mucous nke bronchi, na sinuses, na anụ ahụ dị nro, akpụkpọ ahụ na akụkụ ya, nke na-efe efe. N'ime mmiri interstitial na mmiri, ọgwụ ahụ na-ekpebisi ike n'ụdị na-abụghị protein, na mkpo dị elu karịa na plasma. Na mgbakwunye, a na-ekpebi nnukwu ihe nke arụ ọrụ n'ime akwara afọ na mmiri ọnya ọgbụgba, yana akwara nke akụkụ ahụ nwanyị.

Biotransformes ka mmiri sulfo na glucuronides na-adịghị arụ ọrụ. Moxifloxacin abụghị biotransformziki nke microsomal enzymes nke sistemụ cytochrome P450.

Mgbe ọ gafesịrị usoro nke biotransformation nke abụọ, moxifloxacin na-apụta site n'ahụ mmadụ site na akụrụ na site na eriri afọ, ma agbanweghi ya na ụdị sulfo na-arụ ọrụ na glucuronides.

A na-etisa ya na mmamịrị, yana yana feces, ma na-agbanweghi agbanwe ma n’ụdị metabolites na-adịghị arụ ọrụ. N'iji otu nari 400 mg, ihe dị ka pacenti iri na iteghete na-agbanwegharị na mmamịrị, ihe dị ka 25% na feces. T 1/2 dị ihe dị ka awa 12. Oge ngụkọta nhichapụ mgbe nchịkwa na ọnụọgụ 400 mg bụ site na 179 ml / min ruo 246 ml / min.

Ihe na-egosi na usoro onunu ogwu:

obodo oyibo nke gwadataworo n'obodo, gụnyere pneumonia nke ndị obodo nabatara, ihe ndị metụtara ya bụ ụdị nke microorganisms nwere ọtụtụ ọgwụ mgbochi ọgwụ *,

nnukwu nje sinusitis,

Ọrịa na-adịghị n'ọrịa na nke mgbagwoju anya nke akpụkpọ ahụ yana anụ ahụ dị nro (gụnyere ụkwụ ọrịa mamịrị),

gbagwojuru afọ n’ime afọ ime, tinyere ọrịa polymicrobial, gụnyere ezumike intraperitoneal,

ọrịa ọnya na - agbasighi agbatị nke akụkụ pelvic (gụnyere salpingitis na endometritis).

Were hinemoks n'ime, na-elocha mmiri, ọ naghị ata ata, na-a plentyụ mmiri buru ibu, ọkacha mma mgbe ị gachara nri. Agafela dose a tụrụ aro.

Ọrịa Ọrịa 24 kwa awa (otu oge kwa ụbọchị), mg Ogologo oge ọgwụgwọ, ụbọchị ọnụnọ ọnya na-arịa Ọrịa 4007–14 Ọrịa nje nje na-adịghị ala ala 4007-10 Ọrịa nje na-akpata ọnya ọnya ọnya na ọnya subcutaneous 4007 Ọrịa na-akpata ọnya nke anụ ahụ na nkewa subcutaneous 4007–21

Agafela oge ọgwụgwọ a tụrụ aro ya.

Enweghị mgbanwe mgbanwe usoro onunu ogwu a chọrọ: na ndị ọrịa agadi, ndị ọrịa nwere ọrụ imeju (klas A, B na ọnụ ọgụgụ ụmụaka), ndị ọrịa nwere nsogbu gbasara akụrụ isi (gụnyere ọdịda akwara siri ike na creatinine Cl ≤30 ml / min / 1.73 m2, yana ndị nke na-aga n'ihu ịba ọcha n'anya na ọrịa outitoneal dialysis ogologo oge), ndị ọrịa nke agbụrụ dị iche iche.

Nsonaazụ

Mmeghachi omume nfụkasị akụkụ mmiri metụtara Heinemox: ihe ọkụ ọkụ, itching, urticaria.

Site na sisitemu obi: tachycardia, nsogbu ọgụ, ịba ụba ọbara ọgbụgba, palpitations, mgbu obi.

Site na usoro digestive: afọ mgbu, ọgbụgbọ, afọ ọsịsa, ọgbụgbọ, dyspepsia, flatulence, afọ ntachi, ụba ọrụ nke ọrịa ịba ọcha n'anya, omume uto.

N'akụkụ nke ụlọ nyocha: mbelata nke ọkwa prothrombin, mmụba nke ọrụ amylase.

Site na sistemụ hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, anaemia.

Site n'akụkụ nke sistemụ akwara na akụkụ ụjọ: ụjọ, ụra, ụjọ, nchekasị, ụkwara ume ọkụ, isi ọwụwa, mkpọtụ, paresthesia, mgbu ụkwụ, ihe mgbu, ọgba aghara, ịda mba.

Site na usoro akwara: azụ mgbu, arthralgia, myalgia.

Site na sistemụ omumu: candidiasis, vaginitis.

Ajuju, azịza, nyocha banyere ọgwụ Heinemoks

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke kachasi banyere ogwu ahu di na ntuziaka nke ndi emeputaworo. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Nhazi ọkwa nosological (ICD-10)

Mbadamba ihe mkpuchi	Taabụ 1.
ike ọrụ:
moxifloxacin hydrochloride	436.3 mg
(Akwụkwọ kwekọrọ na moxifloxacin - 400 mg)
ndị na-ebu ụzọ: stachi ọka - 52 mg, sodium lauryl sulfate - 7.5 mg, talc nke dị ọcha - 15 mg, magnesium stearate - 6.5 mg, carboxymethyl starch sodium - 20 mg, ihe na-enye mmiri ọgwụ sịlịkọn colloidal siliki 3,5 - 3.5 mg, croscarmellose sodium - 6.5 mg, MCC - 130.7 mg
n'ọbọ ihe nkiri: Opadry ọcha (85G58977) Mee (polyvinyl mmanya, titanium dioxide, talc, macrogol 3000, lecithin (soy)) - 17.32 mg, red iron oxide - 0.68 mg

Ngwakọta na ụdị ntọhapụ

Mbadamba ụrọ - 1 mbadamba:

Ihe na-arụ ọrụ: moxifloxacin hydrochloride 436.3 mg, nke kwekọrọ na ọdịnaya moxifloxacin 400 mg.
Ndị ọkachamara: stachi ọka - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, talc - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl stachi - 20 mg, silicon dioxide na-egbu egbu - 3.5 mg, croscarmellose sodium - 6,5 mg, microcrystalline cellulose - 130.7 mg.
Ihe mejupụtara Shell: Opadry white 85G58997 Makc-Colorcon (mmanya polyvinyl, titanium dioxide, talc, macrogol 3000, lecithin (soy)) - 17.32 mg, iron oxide uhie - 0.68 mg.

5 pcs. - blisters (1) - ngwugwu nke kaadiboodu.

Mgbe nchịkwa ọnụ gachara, a na-etinye moxifloxacin ngwa ngwa ma ọ fọdụ nke ọma. Mgbe otu moxifloxacin na-a atụ ya na mmiri ọgwụ dị nari 400 mg _max n'ọbara ruru n'ime awa 0.5-4 ma ọ bụ 3.1 mg / l.

Mgbe otu okpukpo na-abia na nha nke mg mg maka hh 1 h _max enwetara na njedebe nke infusion ma ọ bụ 4.1 mg / l, nke kwekọrọ na mmụba dị ihe dịka 26% ma e jiri ya gosipụta uru ngosipụta a mgbe a na-ewere ya ọnụ. Site na otutu infusions nke IV na ọgwụ nke 400 mg na-adịgide 1 h _max dịgasị iche site na 4.1 mg / l ruo 5.9 mg / l. Nkezi Css nke 4.4 mg / L na njedebe nke infusion.

Ezigbo bioavailability dị ihe dịka 91%.

The pharmacokinetics nke moxifloxacin mgbe ewere ya na otu onunu si 50 mg ruo 1200 mg, yana na 600 mg / ụbọchị maka ụbọchị 10, bụ ahịrị.

Ekwadoro steeti etolite n’ime ụbọchị 3.

Indtinye aka na-edozi ọbara (ọkachasị albumin) bụ ihe dịka 45%.

A na - ekesa Moxifloxacin ngwa ngwa n’akwara na akwara. Vd dị ihe dị ka 2 L / n'arọ.

Biotransformes ka mmiri sulfo na glucuronides na-adịghị arụ ọrụ. Moxifloxacin abụghị biotransformziki nke microsomal enzymes nke sistemụ cytochrome P450.

A na-etisa ya na mmamịrị, yana yana feces, ma na-agbanweghi agbanwe ma n’ụdị metabolites na-adịghị arụ ọrụ. N'iji otu nari 400 mg, ihe dị ka pacenti iri asaa na asaa apụtaghị na mmamịrị ahụ, ihe dị ka 25% na feces. T1 / 2 dị ihe dị ka awa 12. Nkezi mkpochapụ mgbe nchịkwa na ọnụọgụ 400 mg sitere na 179 ml / min ruo 246 ml / min.

Ọgwụ antibacterial nke otu fluoroquinolone.

Usoro onunu ogwu nke Heinemox

N'ime, 400 mg 1 oge / ụbọchị. Treatmentzọ ọ ga-esi gwọọ ọrịa bronchitis na-adịghị ala - ụbọchị 5, oyi ịba n’obodo - ụbọchị 10, nnukwu sinusitis, ọrịa nke anụ ahụ na anụ ahụ dị nro - ụbọchị asaa.

Edere Moxifloxacin na ịdọ aka na ntị ma ọ bụrụ na ọria isi (gụnyere akụkọ ihe mere eme), Akwụkwụ na-adọ, ọdịda imeju, ọrịa nke ịgbatị oge etiti QT.

N'oge ọgwụgwọ na fluoroquinolones, mbufụt na mgbaze nke akaị nwere ike ịmalite, ọkachasị ndị ọrịa agadi na ndị ọrịa na-anata corticosteroids n'otu oge. Na ihe ịrịba ama nke mbụ nke ihe mgbu ma ọ bụ mgbu nke akwara, ndị ọrịa kwesịrị ịkwụsị ọgwụgwọ ma hapụ aka na aka ahụ emetụtara site na ibu ahụ.

Mlọ ọgwụ

Moxifloxacin bụ ọgwụ nje na-egbochi nje nke na - egbochi fluoroquinolone, 8-methoxy fluoroquinolone. Ọ na - egbochi topoisomerase nke II na topoisomerase IV, na - akpaghasị nnukwute ngwakọta na njikọta nke DNA, na - egbochi njikọ nke DNA, na - akpata mgbanwe morphological miri emi na cytoplasm, mgbidi sel na membranes nke microorganisms nwere mmetụta.Obere ihe ncheta nke moxifloxacin bụ moxifloxacin na-adịkarị site na iji obere mkpokọta inhibitory (MIC).

Usoro ndị na-eduga na mmepe nke iguzogide penisiliniins, cephalosporins, aminoglycosides, macrolides na tetracyclines anaghị emebi ọrụ antibacterial nke moxifloxacin. Onweghi nguzogide n'etiti otu ndia nke ogwu nje na moxifloxacin. Ruo ugbu a, enweghị okwu ikpe nguzobe plasmid a hụrụ. Oge mmepe nke nguzogide dị obere (10 -7 –10 -10). Nguzogide maka moxifloxacin na-amalite nwayọ nwayọ site na otutu mmụkọ. Mmetụta ugboro ugboro nke moxifloxacin na microorganisms na mkpokọta n'okpuru MIC bụ naanị ntakịrị mmụba na MIC. Ekwuru okwu nke nguzogide nguzogide na quinolones. Na agbanyeghị, ụfọdụ microorganisms gram-positive na anaerobic microorganisms na-eguzogide na quinolones ndị ọzọ ka nwere moxifloxacin.

Moxifloxacin in vitro arụ ọrụ megide ọtụtụ gram-na-adịghị mma na microorganisms, anaerobes, nje na-eguzogide acid na nje na-efe efe dị ka Mycoplasma spp., Chlamydia spp., Legionella spp.yana nje na-eguzogide ọgwụ beta-lactam na ọgwụ nje macrolide.

Ihe dị iche iche nke nje nje ihe moxifloxacin gụnyere microorganisms ndị a.

Ọkpụkpọ dị mma: Gardnerella vaginalis, ọrịa puruonia * (gụnyere ụdị na-eguzogide penisilini na nje nwere ọtụtụ ọgwụ nje), Ike pyogenes (otu A) *, otu Streptococcus milleri (S. anginosus *, S. constellatus *, S. intermedius *), otu ahụ Ptomụ agbọghọ na-amaghị nwoke (ụmụ agbọghọ na-amaghị nwoke, S. mutans, S. mitis, S. sanguinis, S. salivarius, S. thermophilus, S. constellatus), Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus (gụnyere ụdị nsogbu methicillin na-akpata) *, staphylococci coagulase-negative (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans), gụnyere nsogbu metụtara mmetụta methicillin.

Gram-ọjọọ: Haemophilus influenzae (gụnyere ọgịga na-emepụta na nke na-anaghị emepụta beta-lactamases) *, Haemophilus parainfluenzae *, Moraxella catarrhalis (gụnyere ọgịga na-emepụta na nke na-anaghị emepụta beta-lactamases) *, Bordetella pertussis, Legionella pneumophila, Acinetobacter baumannii, Proteus vulgaris.

Anaerobes: Fusobacterium spp., Porphyromonas spp., Prevotella spp., Propionibacterium spp.

Tena: Chlamydia pneumoniae *, Chlamydia trachomatis *, Mycoplasma pneumoniae *, Mycoplasma hominis, Mycoplasma genitalium, Legionella pneumophila *, Coxiella burnetii.

Ọkpụkpọ dị mma: Enterococcus faecalis * (naanị ụdị nwere nsogbu dị ka vancomycin na gentamicin) Enterococcus avium *, Enterococcus faecium *.

Gram-ọjọọ: Escherichia coli *, Klebsiella pneumoniae *, Klebsiella oxytoca, Citrobacter freundii *, Enterobacter spp. (E. aerogenes, E. intermedius, E. sizakii), Enterobacter cloacae *, Pantoea agglomerans, Pseudomonas fluorescens, Burkholderia cepacia, Stenotrophomonas maltophilia, Proteus mirabilis *, Morganella morganii, Neisseria gonorrhoeae * Prov. (P. rettgeri, P. stuartii).

Anaerobes: Bacteroides spp. (B. fragilis *, B. distasonis *, B. thetaiotaomicron *, B. ovatus *, B. uniformis *, B. vulgaris *), Peptostreptococcus spp., Clostridium spp.

Ọkpụkpọ dị mma: Staphylococcus aureus (methicillin / ofloxacin na-egbochi nje) **, coagulase-sta stalococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans)ụdị methicillin na-eguzogide ọgwụ.

Gram-ọjọọ: Pseudomonas aeruginosa.

* Ihe nchoputa maka moxifloxacin ka egosiputara site na data nke ulo ogwu.

** Achọghị ka ojiji nke Heinemox maka ọgwụgwọ nke ọrịa na-akpata site na ụdị. S. aureusna-eguzogide ọgwụ na methicillin (MRSA). N'ihe banyere nke a na-enyo enyo ma ọ bụ gosi na ọrịa na-akpata MRSA, Ekwesịrị ịnye ọgwụ nke iji ọgwụ nje ndị kwesịrị ekwesị.

Ihe ngosi Heinemox

Ọrịa na-efe efe na mkpali kpatara microorganisms nwere mmetụta nke moxifloxacin:

obodo oyibo nke gwadataworo n'obodo, gụnyere pneumonia nke ndị obodo nabatara, ihe ndị metụtara ya bụ ụdị nke microorganisms nwere ọtụtụ ọgwụ mgbochi ọgwụ *,

obi mgbawa nke ụkwara ume ọkụ na-adịghị ala ala,

nnukwu nje sinusitis,

Ọrịa na-adịghị n'ọrịa na nke mgbagwoju anya nke akpụkpọ ahụ yana anụ ahụ dị nro (gụnyere ụkwụ ọrịa mamịrị),

gbagwojuru afọ n’ime afọ ime, tinyere ọrịa polymicrobial, gụnyere ezumike intraperitoneal,

ọrịa ọnya na - agbasighi agbatị nke akụkụ pelvic (gụnyere salpingitis na endometritis).

* Ahụ ike na-efe efe nwere ọtụtụ ọgwụ nje na-egbochi penicillin na-egbochi nje na ụdị na-eguzogide ọgwụ abụọ ma ọ bụ karịa site na otu dịka penicillins (yana MICs ≥ 2 μg / ml), cephalosporins nke abụọ (cefuroxime), macrolides, tetracyclines na trimethoprim / sulfamethoxazole.

Ihe ngbanwe

hypersensitivity na moxifloxacin, quinolones ndị ọzọ ma ọ bụ ihe ndị ọzọ dị n'ọgwụ ahụ.

Ahụhụ nfụkasị ahụekere ma ọ bụ soy,

mmebi akwara na ọgwụgwọ gara aga na quinolones,

n'otu oge iji ọgwụ na-agbatị oge QT (gụnyere ọgwụ antiarrhythmic nke klaasị III, III) - lee “Mmekọrịta”,

ndị ọrịa nwere ọmụmụ ogologo oge ma ọ bụ enwetara ogologo oge nke oge QT, nsogbu nke electrolyte (ọkachasị hypokalemia na-adịghị edozi), bradycardia, na-adakarị ọrịa obi ike na ibelata mgbatị ventricular ekpection, akụkọ ihe mere eme nke ọgba aghara na-esonyere mgbaàmà nke ọrịa (ojiji nke moxifloxacin Q na-eduga na-eduga ),

ndị ọrịa nwere ọrịa imeju na-arụ ọrụ (nhazi ọkwa nke nwatakịrị-Pugh) na mmụba nke ọrụ transaminase karịa ugboro ise karịa VGN,

ụmụaka na-erubeghị afọ 18.

Iji nlezianya: Ọrịa CNS (gụnyere ndị ahụ na-enyo enyo na ntinye CNS) na-ekwupụta ihe ọdịdọ ma belata ọnụ ụzọ nke ọrụ nkwarụ, ndị ọrịa nwere akụkọ banyere psychosis na ọrịa uche, ndị ọrịa nwere ọnọdụ proarrhythmic dị ka nnukwu myocardial ischemia, karịsịa na ụmụ nwanyị na ndị ọrịa agadi, myasthenia gravis gravis, ọrịa imeju, iji ọgwụ na-ebelata potassium.

Mmekorita

Enweghi mmekorita di omimi banyere moxifloxacin na atenolol, ranitidine, mgbakwunye nke calcium, theophylline, ọgwụ mgbochi, glibenclamide, itraconazole, digoxin, morphine, probenecid. Achọzigharị usoro usoro usoro ọgwụgwọ mgbe ejikọtara ya na ọgwụ ndị a.

Ihe antacids, mineral na multivitamins. Ojiji nke moxifloxacin na nkwadebe antacid, mineral na multivitamins nwere ike kpaghasị nnabata nke moxifloxacin n'ihi nguzo nke chelate ogige ya na polyvalent cations dị n’ime ọgwụ ndị a, yabụ belata mkpokọta moxifloxacin na plasma ọbara. N'akụkụ a, ọgwụ antacid, antiretroviral ọgwụ (dịka didanosine) na ọgwụ ndị ọzọ nwere magnesium, aluminom, sucralfate, iron, zinc kwesịrị dị ka awa 4 tupu ma ọ bụ 4 awa mgbe nchịkwa ọnụ nke moxifloxacin.

Ọgwụ na-agbatị etiti oge QT. Ebe moxifloxacin na-emetụta ogologo oge nke oge QT, ojiji jikọtara ojiji nke moxifloxacin na ọgwụ ndị na-esote: antiarrhythmic IA (quinidine, hydroquinidine, viopyramide, wdg) na III (amiodarone, sotalol, dofetilide, ibutilide, wdg) akwara, tricypticics phenothiazines, pimozide, sertindole, haloperidol, sultopride, wdg, antimicrobial (sparfloxacin, erythromycin, pentamidine, ọgwụ antimalarial, karịsịa halofantrine), antihistamines (astemizole, terfenadine, misolastine) na ndị ọzọ (cisis) mpako, vincamine, bepridil, difemanil) ego.

Warfarin. Mgbe ejikọtara ya na warfarin, PV na mgbochi ọbara ọbara ndị ọzọ anaghị agbanwe agbanwe. Agbanyeghị, na ndị ọrịa na-anata anticoagulants yana ọgwụ nje, gụnyere na moxifloxacin, enweela ikpe nke ịba ụba ọgwụ anticoagulant. Ihe ndị dị ize ndụ bụ ọnụnọ nke ọrịa na-efe efe (yana usoro mkpali), afọ na ọnọdụ onye ọrịa niile. N'agbanyeghị eziokwu ahụ bụ na achọpụtaghị mmekọrịta dị n'etiti moxifloxacin na warfarin, na ndị ọrịa na-anakọta ọgwụgwọ yana ọgwụ ndị a, ọ dị mkpa iji nyochaa ọnụ ahịa INR ma, ọ bụrụ na ọ dị mkpa, dozie ọgwụ nke anticoagulants na-apụtaghị ìhè.

Digoxin. Moxifloxacin na digoxin emetụtachaghị ọgwụ ọgwụ nke ibe ha. Na ugboro ole onyosis nke moxifloxacin C_max digoxin mụbara ihe dịka 30%, ebe ụkpụrụ nke AUC na C_min digoxin agbanweghi.

Carbon na-arụ ọrụ. N'iji oge nke carbon na moxifloxacin na-arụ ọrụ n'ime ya na ọnụọgụ 400 mg, sistemụ bioavailability nke moxifloxacin na-ebelata ihe karịrị 80% n'ihi mmachi nke ịmịkọrọ ya.

GCS. N'iji moxifloxacin na corticosteroids oge, enwere ihe ọghọm nke ibute ọrịa akwara na nkụ na-abawanye.

Usoro onunu ogwu na nhazi

N'ime na-elocha mmiri, ọ naghị ata ata, na-a plentyụ mmiri buru ibu, ọkacha mma mgbe ị gachara nri. Agafela dose a tụrụ aro.

Ofufe Ọrịa	Dose kwa awa 24 (otu oge kwa ụbọchị), mg	Oge ọgwụgwọ, ụbọchị
Ahụ ọkụ na-efe efe nke ime obodo	400	7–14
Anwụ nke bronchitis na-adịghị ala ala	400	5–10
Ọrịa jisiri na-akpata nnukwu ọrịa	400	7
Akpụkpọ ahụ na-adịghị mgbagwoju anya na ọrịa anụ ahụ dị nro	400	7
Ọrịa bute ọnyá anụahụ na akụkụ nke akụkụ ala dị n'okpuru	400	7–21
Ọrịa intraabdominal na-efe efe	400	5–14
Ọrịa na - emetụtaghị ọrịa nke akụkụ ahụ nke akụkụ pelvic	400	14

Agafela oge ọgwụgwọ a tụrụ aro ya.

Enweghị mgbanwe mgbanwe usoro onunu ogwu a chọrọ: na ndị ọrịa agadi, ndị ọrịa nwere ọrụ imeju (klas A, B na ọnụ ọgụgụ ụmụaka), ndị ọrịa nwere nsogbu gbasara akụrụ isi (gụnyere ọdịda akwara siri ike na creatinine Cl ≤30 ml / min / 1.73 m 2, yana ndị na-aga n'ihu na-agwọ ọrịa na-aga n'ihu na usoro ọgwụgwọ ọrịa ogologo oge), ndị ọrịa nke agbụrụ dị iche iche.

Dodoụbiga ya ókè

Ọgwụgwọ: bụrụ na ị ofụbiga ihe ọdoụdoụ ókè, mmadụ kwesịrị idozi ya site na ndenye ụlọ ọgwụ ma na-eduzi usoro ọgwụgwọ na-akwado usoro ọgwụgwọ na nyocha ECG. Nlekọta nke carbon emegharịrị ozugbo enwere nchịkwa ọnụ ọgwụ nke ọgwụ ahụ nwere ike inye aka gbochie sistemụ oke moxifloxacin n'ihe banyere oke ịdoụbiga mmanya ókè.

Ntụziaka pụrụ iche

N'ọnọdụ ụfọdụ, mgbe ị firstụsịrị ọgwụ mbụ, ịba ọcha na mmeghachi ahụ nfụkasị nwere ike ịmalite, nke ekwesịrị ịgwa dọkịta ozugbo. Ọ dịkarịghị ala, mmeghachi omume anaphylactic nwere ike ịga n'ihu na ihe atụ nke ndụ anaphylactic, ọbụlagodi mgbe ị firstụ ọgwụ mbụ. N'ọnọdụ ndị a, a ga-akwụsị ịgwọ ọrịa Heinemox na usoro ọgwụgwọ dị mkpa (gụnyere mgbochi oke).

Mgbe ị na-eji ọgwụ Heinemox na ụfọdụ ndị ọrịa, enwere ike ịmịpụta ndọtị QT. Associatedgbatị oge nke QT na-esonye n'ihe egwu dịwanye elu nke nsogbuhythmias polymorphic, gụnyere tachycardia polymorphic. Enwere mmekọrịta kpọmkwem n'etiti mmụba nke moxifloxacin na mmụba na etiti oge QT. N'ihi ya, usoro a tụrụ aro (400 mg / ụbọchị) ekwesịghị gafere.

Ọrịa na ụmụ nwanyị meworo agadi na-aka elebara ọgwụ ike nke na-agbatị oge QT. Mgbe ị na-a drugụ ọgwụ Heinemox, ihe ize ndụ nke ịmalite ọrịa ventricular arrhythmias na ndị ọrịa nwere ọnọdụ na-ekwu maka arrhythmias nwere ike ịba ụba. N'akụkụ a, enweghị ike iji ọgwụ Heinemox mee ihe n'ọnọdụ ndị a: congenital ma ọ bụ enwetara ogologo oge nke oge QT, hypokalemia na-enweghị ọgwụgwọ, bradycardia dị ukwuu, nkụchi obi dị ukwuu na mkpịsị aka mgbanaka na-ebelata nke ukwuu, akụkọ ihe mere eme nke akwara arrhythmias tinyere ọrịa mgbaasị, nhazi oge. ọgwụ na-agbatịkwu oge nke QT (gụnyere ọgwụ antiarrhythmic nke klas IA, III) na ndị ọzọ (lee "Mmekọrịta").

Mgbe ị na-eji ọgwụ ahụ Heinemox, achọpụtala banyere mmepe nke ịba ọcha n'anya zuru oke, nke nwere ike iduga mmepe mmepe nke imeju. Ọ bụrụ na ihe mgbaàmà nke mmerụ imeju na-apụta, ịkwesịrị ịgakwuru dọkịta tupu ịga n'ihu na ọgwụgwọ ọgwụ.

Mgbe ị na-a theụ ọgwụ Heinemox, a kọọrọ akụkọ banyere mmepe nke ọnya anụ ahụ (Stevens-Johnson syndrome ma ọ bụ nchikota necrolysis). Ekwesịrị ịgwa onye ọrịa ahụ na ọ bụrụ na mgbaàmà nke akpụkpọ ma ọ bụ akpụkpọ ahụ mucous, ọ dị mkpa ịkpọtụrụ dọkịta tupu ịga n'ihu na-ewere Heinemox.

Ojiji nke quinolone ogwu jikọtara ya na enwere ike ibute ihe ọdịdọ. A ga-eji Heinemox kpachara anya na ndị ọrịa nwere ọrịa nke sistemụ akwara etiti yana nsogbu nke usoro akwara ozi nke na-ebute ihe ọdịdọ ma ọ bụ belata nbata imebi ihe.

Ekwesiri iji Heinemox jiri nlezianya mee ihe na ndị ọrịa nwere myasthenia gravis. gravis n'ihe banyere enwere ike wepu ọrịa a.

A ga-eji Heinemox kpachara anya na ndị ọrịa nwere ụkọ glucose-6-phosphate dehydrogenase n'ihi mmepe mmeghachi omume haemolytic.

Ojiji nke ọgwụ nje sara mbara, gụnyere Heinemox, nwere ihe ọghọm nke ọrịa nje pseudomembranous. Ekwesịrị ibute nchọpụta nke ọrịa a na ndị ọrịa a na-ahụta nnukwu afọ ọsịsa n'oge ọgwụgwọ Heinemox. N'okwu a, ekwesịrị ịkwụsị ọgwụ ahụ ma kwekọọ n'ọgwụgwọ kwesịrị ekwesị. Ọgwụ ndị na-egbochi ịba uru nke imeju na-egbochi mmepe nke afọ ọsịsa.

Na ndabere nke ọgwụgwọ quinolone, gụnyere moxifloxacin, mmepe nke tendonitis na tendon rupture ga-ekwe omume, ọkachasị ndị ọrịa agadi na ndị ọrịa na-anata corticosteroids oge. Na ngosipụta nke mbụ nke ihe mgbu ma ọ bụ mbufụt nke akwara, ị kwesịrị ịkwụsị ị takingụ ọgwụ ahụ wee mee ka aka ahụ emetụtara.

Moxifloxacin enweghị mmetụta na-eme ka ọ bụrụ ọgwụ, Otú ọ dị, a na-atụ aro izere radieshon UV n'oge ọgwụgwọ ya na ọgwụ ahụ, gụnyere anwụ anwụ.

A naghị atụ aro iji moxifloxacin maka ọgwụgwọ nke ọrịa na-akpata ụdị. Staphylococcus aureusna-eguzogide ọgwụ na methicillin (MRSA). N'ihe banyere nke a na-enyo enyo ma ọ bụ gosi na ọrịa na-akpata MRSA, ịchọrọ ị withụ ọgwụ mgbochi nje kwesịrị ekwesị ekwesịrị inye ọgwụ (lee "Pharmacodynamics").

Ike nke ọgwụ Heinemox igbochi uto nke mycobacteria nwere ike ibute mmekọrịta in vitro moxifloxacin na ule maka Mycobacterium spp., na-eduga na nsonaazụ ụgha na nyocha nke nyocha nke ndị ọrịa na-agwọ na Heinemox n'oge a.

N'ime ndị ọrịa ejirila quinolones, gụnyere Heinemox, akọwaala ikpe gbasara sensọ ma ọ bụ sensorimotor polyneuropathy, na-eduga na paresthesia, hypesthesia, dysesthesia, ma ọ bụ adịghị ike. A ga-adọ ndị ọrịa na-agwọ ọrịa Heinemox aka na ntị banyere mkpa ọ dị ịkpọtụrụ dọkịta ozugbo tupu ọ gaa n'ihu ọgwụgwọ maka mgbaàmà nke neuropathy, gụnyere mgbu, ọkụ, ntigbu, ọnya ma ọ bụ adịghị ike (lee “Nsonaazụ”).

Mmeghachi omume ụbụrụ nwere ike ime ọbụlagodi mgbe emechara nke mbụ nke fluoroquinolones, gụnyere moxifloxacin. N’oge ndị a na-adịghị ahụkebe, ịda mba ma ọ bụ mmetụta uche na-aga n’ihu iche echiche igbu onwe ya na akparamagwa nke imerụ onwe ya ahụ, gụnyere ịgbalị igbu onwe ya (lee “mmetụta ndị na-adịghị mma”). Ọ bụrụ na mmeghachi omume ndị dị otú a malitere na ndị ọrịa, ekwesịrị ịkwụsị ọgwụ Heinemox yana usoro ndị dị mkpa.

N'ihi mgbasa zuru ebe niile na-arịwanye elu nke ọrịa na-akpata fluoroquinolone na-eguzogide Neisseria gonorrhoeae, n'ịgwọ ndị ọrịa nwere ọrịa mbufụt nke akụkụ ahụ pelvic, moxifloxacin monotherapy agaghị arụ ọrụ. Ewezuga mgbe ọnụnọ nke fluoroquinolone na-eguzogide N. gonorrhöeae ewepuru. Ọ bụrụ na ọ gaghị ekwe omume iwepu ọnụnọ nke fluoroquinolone na-eguzogide N. gonorrhoe, Ọ dị mkpa iji dozie okwu banyere ịgbakwunye ọgwụ mgbu na moxifloxacin na ọgwụ mgbochi kwesịrị ekwesị nke na-arụ ọrụ megide N. gonorrhöeae (dịka cephalosporin).

Mmetụta ikike ịnya ụgbọ ala na igwe na-agagharị. Fluoroquinolones, gụnyere moxifloxacin, nwere ike imebi ikike nke ndị ọrịa ịnya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor n'ihi nsonaazụ na sistemụ akwara na imerụ ahụ.

Emeputa

Highglans Laboratories Pvt. Ltd. E-11, 12 & 13, Site-B, UPSIDC, Surajpur, Mpaghara Mpaghara, Greater Noida-201306, (U.P.), India.

Tẹ.: +91 (120) 25-69-742, faksị: +91 (120) 25-69-743.

ozi-e: [email protected], www.higlance.com

Onye nnọchi anya nke onye nrụpụta na Russian Federation: Pharma Group LLC. 125284, Moscow, abụrụ. Na-agba ọsọ, 13.

Tel./fax: +7 (495) 940-33-12, 940-33-14.

Weputara udi ya na ihe mebere ya

A na-ere ọgwụ antimicrobial n'ụdị mbadamba 400 mg nke moxifloxacin (akụrụngwa nọ n'ọrụ).

Ihe ndi ozo mejuputara:

ihe na-enye uko uyi na ogwu
sodium croscarmellose
cellulose microcrystals,
stereta magnesium,
ntụ ọka peeled
sodium lauryl sulfate,
3000 macrogol
soya lecithin,
iron oxide,
White Opadry 85G58977.

Ihe ngosi maka ojiji

Ọrịa na-esochi ọnya na-efe efe nke microorganisms na-akpasu iwe banyere ọgwụ:

obodo oyibo nwetara site na Streptococcus anginosus na Streptococcus milleri,
nnukwu ogbo nke ala ala ụkwara ume ala,
sinusitis (nnukwu), nke nje pathogenic kpasuru iwe,
ọrịa nje na-efe efe n'ime afọ (gụnyere ọrịa polymicrobial),
ọnya anụ ahụ na ọnya anụ ahụ dị nro,
ọrịa ọrịa pelvic, gụnyere endometritis na salpingitis.

Edere Heinemox maka ọrịa mbufụt nke akụkụ ahụ pelvic.
N’ibute ọrịa akpụkpọ, Heinemox ka edepụtara.Edebere Thrombomagum maka mmebi nke akụkụ okuku ume.
Edere ọgwụ a maka oyi baa.
Site na sinusitis, ọ bụ omenala ịre Heinemox.

Otu esi ewere Heinemox

Ekwesịrị ị oụ mbadamba ọgwụ antimicrobial ka dum, jiri mmiri sachaa ya. Ọ dị mma ime nke a mgbe nri gasịrị.

oyi baa (ụdị obodo enwetara): a na-a drugsụ ọgwụ n’ime irighiri mmiri nke 400, ọgwụ na-anọ otu izu rue izu abụọ.
bronchitis (ya na oke iwe): ọgwụ kwa ụbọchị - 400 mg, oge nchịkwa - 5-10 ụbọchị,
nje sinusitis: A na-enye ọgwụ ọgwụ mg mg 400 kwa ụbọchị, oge ọgwụgwọ bụ izu 1,
ọnya anụ / subcutaneous na-efe efe: dose - 400 mg, oge ọgwụgwọ - site na 1 ruo izu atọ,
Ọrịa nje na-efe efe n'ime afọ: usoro ọgwụgwọ - 400 mg, oge ọgwụgwọ - site na ụbọchị ise ruo ụbọchị iri na anọ,
ọnya ọnya (anaghị agbagha), dị na akụkụ akụkụ pelvic: nkezi kwa ụbọchị - 400 mg, oge nchịkwa - izu abụọ.

Ekwesịrị ị oụ mbadamba ọgwụ antimicrobial ka dum, jiri mmiri sachaa ya.

Ọkpụkpụ afọ

afọ mgbu
ọgbụgbọ
afọ ọsịsa
flatulence
nri riri
stomatitis
dysphagia
colitis (ụdị pseudomembranous),
eriri afọ.

N'oge nlekọta ọgwụ ahụ, akwara nwere ike ime.
Mgbu n'ime afọ bụ mmetụta dị n'akụkụ ọgwụ ọgwụ Thrombomag.
N'oge ọgwụgwọ Heinemox, ibelata agụụ ga-ekwe omume.
Ogwu nwere ike ibute oria afọ.Mgbe ị na-ewere thrombomag, ọgbụgbọ na ọgbụgbọ pụrụ ịmalite.

Sistemụ akwara Central

anya ntughari
dysesthesia / paresthesia,
njọ na uto
ndaba,
ehighi ura
ịda mba
vertigo
ike ọgwụgwụ
iro ụra
Ihe ojoo
nsogbu ụbara ọrụ,
hyperesthesia.

Mgbe ị na-a theụ ọgwụ ahụ, ọdịdị nke adịghị ike n'ozuzu ga-ekwe omume.
Ọ bụ nkụda mmụọ na-adịgide adịgide bụ ihe ndị dị n'ị ofụ Aspirin.
Incusnia bụ otu n'ime mmetụta ndị ọgwụ ọjọọ na-akpata.
Heinemox nwere ike ime ka iro ụra.

Site n'akụkụ nke metabolism

hyperuricemia
mụbara elu bilirubin,
hyperglycemia
hyperlipidemia.

eosinophilia
mmeghachi omume anaphylactic,
ihe nwu
Udeme nke Quincke
oji ibia laryngeal (ndu mmadu).

Ọrịa ntị na ọnya ọnya nwere ike apụta mgbe ụfọdụ.

N'oge ọgwụgwọ Heinemox, ngosipụta nke ịrụ ọrụ nke obi ga-ekwe omume.

Mmanya ndakọrịta

Onye rụpụtara anaghị enye ozi gbasara ụdị njikọ a.

Avelox bụ analog nke Heinemox.
Thetụ ụtụ nke ọgwụ Heinemox - Maxiflox.
Kama Heinemox, a na-atụzi Vigamox mgbe ụfọdụ.A na-enye Rotomox oge ụfọdụ kama Heinemox.