Fraxiparin ngwọta analog

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Fraxiparin. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara ojiji Fraxiparin na omume ha. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Analogs nke Fraxiparin n'ihu ọnụnọ analogues dị n'ụdị dịnụ. Jiri maka ọgwụgwọ na mgbochi nke thrombosis na thromboembolism na ndị okenye, ụmụaka, yana n’oge ime na lactation.

Fraxiparin - a bụ heparin dị ala nke dị ala (NMH) nwetara site na depolymerization site na heparin ọkọlọtọ, bụ glycosaminoglycan nwere ogo molecule dị 4300 daltons.

Ọ na-egosipụta ike dị elu nke nwere ike ijikọ protein protein na antithrombin 3 (AT 3). Nchịkọta a na - eduga n'ịgbazi ike nke ihe 10a, nke nwere ike antithrombotic dị elu nke nadroparin (ihe na - arụ ọrụ nke ọgwụ Fraxiparin).

Otherzọ ndị ọzọ na-enye nsonaazụ antithrombotic nke nadroparin gụnyere ịgbalite mgbochi anụ ahụ na-egbochi ntụgharị (TFPI), ịgbalite fibrinolysis site na ntọhapụ nke onye na - eme ka plasminogen anụ ahụ na mkpụrụ ndụ endothelial, yana ịgbanwe ihe ndị dị na rheological ọbara (iwetula viscosity ọbara na ịbawanye ike nke platelet na membranes granulocyte).

A na-amata Calrop nadroparin site na oke ihe mgbochi 10a dị elu ma e jiri ya tụnyere ihe mgbochi 2a ma ọ bụ ọrụ antithrombotic ma nwee ma ọgwụ antithrombotic dị nso ma dị ogologo.

E jiri ya tụnyere heparin na-adịghị arụ ọrụ, nadroparin nwere obere mmetụta na platelet na nchịkọta, yana mmetụta dị ala na hemostasis bụ isi.

N'ime usoro onyonyo prophylactic, Fraxiparin anaghị ebute mbelata nke APTT.

N'ime usoro ọgwụgwọ n'oge arụ ọrụ kachasị, mmụba na APTT ruo uru 1.4 dị elu karịa ọkọlọtọ ahụ ga-ekwe omume. Ogologo oge dị otú a na-egosipụta nsị antithrombotic mmetụta nke calcium nadroparin.

Ngwakọta

Calcium nadroparin + ndị anụrị.

Mlọ ọgwụ

A na-ekpebi ihe ndị dị na Pharmacokinetic na ntọala nke mgbanwe na ihe mgbochi 10a nke plasma.

A na-etinye Fraxiparin ihe fọrọ nke nta ka ọ bụrụ kpamkpam (ihe dị ka 88%). Site na nchịkwa intraven, a na-enweta oke mgbochi 10a na erughị nkeji iri. Ọ bụ metabolized n'ime imeju site na nkụda mmụọ na depolymerization.

Nsonaazụ nke ọmụmụ a gosipụtara na enwere ike ịhụ ntakịrị ihe nadroparin na ndị ọrịa nwere nsogbu ịgbazigharị dị nro ma ọ bụ nke na-adịghị ala ala (CC ≥ 30 ml / min na

Ntụziaka maka ojiji na usoro onunu ogwu

Etu esi etinye ebe inyocha Fraxiparin - Usoro ịgba ntụtụ

Site na nchịkwa subcutaneous, a na-ahụkarị ọgwụ ahụ n'ọkwa onye ọrịa, na anụ ahụ dị n'okpuru ala nke afọ ma ọ bụ akụkụ azụ nke afọ, ọzọ na aka nri na n'akụkụ aka ekpe. Ahapụrụ gị ka ọ banye na apata ụkwụ.

Iji zere ọnwụ nke ọgwụ mgbe ị na-eji sirinji, ekwesighi iwepu ntụfu ikuku tupu ntụtụ.

Ekwesịrị itinye agịga ahụ n'otu oge, ọ bụghịkwa n'akụkụ ya, n'ime akpụkpọ ahụ akpọrọ akpọrọ n'etiti etiti ukwu na isi aka. Ekwesịrị ịdịgide ogige ndị ahụ n'oge nlekọta nke ọgwụ. Etekwala ebe a na-anya ntụtụ gị.

Maka igbochi thromboembolism na usoro ịwa ahụ, ọgwụ a tụrụ aro Fraxiparin bụ 0.3 ml (2850 anti-10a ME) s / c. A na-enye ọgwụ ahụ ruo awa 2-4 tupu awaa ya, mgbe ahụ - oge 1 kwa ụbọchị. A na-aga n'ihu ọgwụgwọ ọ dịkarịa ala ụbọchị 7 ma ọ bụ oge dum nke ihe ize ndụ nke thrombosis, ruo mgbe agafere onye ọrịa na ọnọdụ outpatient.

Iji gbochie thromboembolism n'oge arụ ọrụ orthopedic, a na-achịkwa Fraxiparin subcutaneously na dose nke dabere na ahụ aru nke onye ọrịa na ọnụego 38 anti-10a IU / kg, nke enwere ike ịbawanye 50% na ụbọchị 4 postoperative. Edere ọgwụ izizi ka elekere iri na abụọ tupu awaa ya, nke abụọ - awa iri na abụọ ka ọ rụchara ọrụ ahụ. Ọzọkwa, a na-eji Fraxiparin na-eji ya otu ugboro n'ụbọchị oge dum nke ohere nke thrombosis ruo mgbe a gafere onye ọrịa na ọnọdụ outpatient. Oge opekempe nke ọgwụgwọ bụ ụbọchị iri.

Na ọgwụgwọ nke angina pectoris na-ejighị n'aka na infarction myocardial na-enweghị ebili mmiri Q, a na-enye Fraxiparin sc ugboro abụọ kwa ụbọchị (awa 12 ọ bụla). Oge ọgwụgwọ ọ na-abụkarị 6 ụbọchị. N'ime ọmụmụ ụlọ ọgwụ, ndị ọrịa nwere nkwarụ angina pectoris / myocardial infarction na-enweghị Q ife Fraxiparin ka etinyere yana acetylsalicylic acid na dose nke 325 mg kwa ụbọchị.

A na-elele usoro izizi a dị ka ntụtụ bolliyo intravenous, a na-achịkwa usoro onyonyo na subcutaneously. Emebere ọgwụ a dabere na ịdị arọ nke anụ ahụ na ọnụego 86 anti-10a IU / n'arọ.

N'ime ọgwụgwọ nke thromboembolism, ọgwụ anticoagulants (na-enweghị contraindications) ka a ga-edepụtara ozugbo enwere ike. Ọgwụ ọgwụgwọ na Fraxiparin anaghị akwụsị ruo mgbe ebumnuche nke prothrombin oge egosi. A na-enye ọgwụ ọgwụ s / c ugboro 2 n'ụbọchị (awa 12 ọ bụla), oge ọ na-agụ ya bụ ụbọchị iri. Ọgwụ a dabere na ịdị arọ nke onye ọrịa ahụ dabere na 86 anti-10a IU / kg body body.

Mmetụta akụkụ

• ọbara nke ebe dị iche iche,
• thrombocytopenia
• eosinophilia, enwere ike ibughari ya mgbe ịkwụsị ọgwụ ya,
• Mmeghachi omume hypersensitivity (edema nke Quincke, mmeghachi omume anụ ahụ),
• guzobe obere hematoma subcutaneous na ntụtụ,
• akpụkpọ anụ necrosis, ọ na - abụkarị na ntụtụ,
• onyinye amara
• hyperkalemia chigharịrị (ejikọtara na ike nke heparins iji gbochie nzuzo nke aldosterone, karịsịa na ndị ọrịa nọ n'ihe ize ndụ).

Ihe ngbanwe

• thrombocytopenia nke nwere nadroparin,
• ihe ịrịba ama nke ọbara ọgbụgba ma ọ bụ ohere dị ukwuu nke ọbara ọgbụgba na-emetụta ya hemostasis (ma e wezụga DIC ọ bụghị heparin kpatara).
• mmebi nke anụ ahụ nwere oke agba ọbara (dịka ọmụmaatụ, ọnya afọ ma ọ bụ ọnya afọ),
• mmerụ ahụ ma ọ bụ usoro ịwa ahụ na ụbụrụ na ogwurugwu ma ọ bụ n'anya,
• ọbara ọgbụgba n'ime intracranial,
• nnukwu seoc enditis,
• nnukwu ọdịda gbasara akụrụngwa (CC

Analogs nke ọgwụ Fraxiparin

Ihe analog dị ọnụ karịa 2164 rubles.

Wessel Douay F bụ onye na - eme ihe anticoagulant nke na - eduzi sulodexide na usoro nke 250 LE. Enwere ike inye ya ọgwụ maka ọghọm ọrịa ụbụrụ, akwara vidiyo na -akpata, vein thrombosis nke miri emi na ọrịa ndị ọzọ.

Ihe analog dị ọnụ karịa 527 rubles.

Emeputa: Sanofi Winthrop Mmeputa (France)
Mwepụta Mwepụta:

• Syringe dị puku 10. Anti-ChAME / ml 0.6 ml, 2 PC., Ọnụ ahịa site na 826 rubles

Clexane bụ onye na-eme ihe anticoagulant bụ onye France. Ọ dị n'ụdị edozi nwere sodium enoxaparin. Edere ya dịka ọgwụ proromlactic maka thrombosis venous, yana maka ọgwụgwọ nke thrombosis nke miri emi. N’oge ime ime na lactation ka a ga-edenye ya naanị n’ọnọdụ ndị pụrụ iche.

Ihe analogue dị ọnụ karịa 1428 rubles.

Anfibra bụ analog dịtụ ọnụ karịa maka mmepụta ụlọ. Erere na ngwugwu nke ampoules iri, nke ha nwere nkpuruxaparin sodium. N'ihi ọdịiche dị na ihe mejupụtara ya, ọ nwere ike rụọ ọrụ dịka enwere ike dochie anya naanị mgbe emesịrị dọkịta.

Ihe analogue dị ọnụ karịa 1868 rubles.

Angioflux bụ ọgwụ Russia sitere na otu mpaghara ọgwụ. Ọ dị iche na Fragmin na usoro mejupụtara, mana nwere ụdị yiri ya. Enwere ike ịkọwa ya maka angiopathy, ohere dị ukwuu nke thrombosis, usoro mmalite nke ischemia dị ala. E nwere ọdịiche na contraindications na mmetụta ndị ọ ga-ekwe omume.

Ihe analog dị ọnụ karịa 1256 rubles.

Emeputa: Vetter Pharma-Fertigung GmbH (Germany)
Mwepụta Mwepụta:

• Syringe 2500 IU, 0.2 ml, pcs 10., Ọnụahịa site na 1555 rubles

Fragmin bu ogwu nke emechara nke German nke emeputara na uzo a ga - esi dozie ochichi intraineous and subcutaneous. Enwere ike ịkọwa ya maka ọgwụgwọ nke nnukwu vein thrombosis na akwara umeji, angina na infarction na-akwụghị chịm (enweghị ebili Q na ECG), yana iji gbochie thrombosis n'oge ihe ịwa ahụ.

Ihe analog dị ọnụ karịa 1418 rubles.

Enixum bụ onye nnọchi Wessel Douay F anticoagulant edinam, nke nwere ụdị ya. Ihe di iche na nke mbu n’ime udiri mmanu nke oma - enoxaparin sodium. A na-edozi ọgwụ ahụ n'ụzọ miri emi n'okpuru ma ọ bụ intravenously. Agbabeghị nchekwa na o kwere omume ịkọ banyere ọgwụ ọgwụ nye ụmụaka ndị na-erubeghị afọ 18.

Ihe analogue dị ọnụ ala site na 134 rubles.

Emeputa: Italfarmako S.p.A. ()Tali)
Mwepụta Mwepụta:

• Syringe 10 puku mgbochi Ha ME / ml 0.2 ml, 1 pc., Ọnụ ahịa site na 165 rubles

Ngwa ahịa Italiantali dị ọnụ ala. A na-ere ya n'ụdị ihe ngwọta maka nchịkwa subcutaneous na sinxaparin sodium na dosages site na 2000 ruo 6000 IU ka eji ebe a dị ka ihe na-arụ ọrụ. Dabere na njiri mara isi maka nhọpụta ahụ, ọ dị ka Clexane ma edekwa ya maka thrombosis (ọgwụgwọ na mgbochi).

Ihe ngosi maka ojiji

Kedu ihe na-enyere Fraxiparin aka? Dabere na ntuziaka ndị ahụ, edepụtara ọgwụ ahụ n'okwu ndị a:

• igbochi nsogbu ụbụrụ nke thromboembolic n'oge usoro ọgwụgwọ ma ọ bụ ọgwụgwọ orthopedic,
• n'ime ndị ọrịa nwere nnukwu ihe metụtara nsogbu thromboembolic (ọdịda okuku ume na / ma ọ bụ ọrịa na-efe efe nke akụkụ okuku ume, na / ma ọ bụ nkụchi obi) n'ụlọ ọgwụ na ngalaba nlekọta kpụ ọkụ n'ọnụ, ọgwụgwọ nke nsogbu nke thromboembolic,
• igbochi coagulation ọbara n'oge ịba ọcha n'anya, ọgwụgwọ nke angina na-ejighị n'aka na nkwarụ myocardial na-enweghị ebugharị Q na-adịghị emerụ ahụ na ECG.

Ntụziaka maka iji Fraxiparin, usoro onunu ogwu

Site na nchịkwa subcutaneous, a na-ahụkarị ọgwụ ahụ n'ọkwa onye ọrịa, na anụ ahụ dị n'okpuru ala nke afọ ma ọ bụ akụkụ azụ nke afọ, ọzọ na aka nri na n'akụkụ aka ekpe. Ahapụrụ gị ka ọ banye na apata ụkwụ.

Iji zere ọnwụ nke ọgwụ mgbe ị na-eji sirinji, ekwesighi iwepu ntụfu ikuku tupu ntụtụ.

Ekwesịrị itinye agịga ahụ n'otu oge, ọ bụghịkwa n'akụkụ ya, n'ime akpụkpọ ahụ akpọrọ akpọrọ n'etiti etiti ukwu na isi aka. Ekwesịrị ịdịgide ogige ndị ahụ n'oge nlekọta nke ọgwụ. Etekwala ebe a na-anya ntụtụ gị.

• Maka mgbochi nke thromboembolism na usoro ịwa ahụ, ọgwụ a tụrụ aro Fraxiparin bụ 0.3 ml (2850 anti-Xa ME) s / c. A na-enye ọgwụ ahụ ruo awa 2-4 tupu awaa ya, mgbe ahụ - oge 1 kwa ụbọchị. A na-aga n'ihu ọgwụgwọ ọ dịkarịa ala ụbọchị 7 ma ọ bụ oge dum nke ihe ize ndụ nke thrombosis, ruo mgbe agafere onye ọrịa na ọnọdụ outpatient.
• Iji gbochie thromboembolism n'oge arụ ọrụ orthopedic, a na-achịkwa Fraxiparin subcutaneously na nha nha nke onye ọrịa dabere na 38 anti-XA IU / kg, nke enwere ike ịbawanye 50% na ụbọchị 4 postoperative. Edere ọgwụ izizi ka elekere iri na abụọ tupu awaa ya, nke abụọ - awa iri na abụọ ka ọ rụchara ọrụ ahụ. Ọzọkwa, a na-eji Fraxiparin na-eji ya otu ugboro n'ụbọchị oge dum nke ohere nke thrombosis ruo mgbe a gafere onye ọrịa na ọnọdụ outpatient. Oge opekempe nke ọgwụgwọ bụ ụbọchị iri.
• Ndị ọrịa nwere nnukwu thrombosis (nke a na-anọkarị na ngalaba nlekọta ahụike / ngalaba nlekọta oke / ọdịda iku ume na / ma ọ bụ ọrịa akụkụ iku ume na / ma ọ bụ nkụda obi) /) onye ọrịa. Itinye oge niile nke ihe ize ndụ nke thrombosis.
• N'ime usoro ọgwụgwọ angina pectoris na-ejighị n'aka na infarction myocardial na-enweghị ebili mmiri Q, a na-ede s / c ugboro 2 n'ụbọchị (awa 12 ọ bụla). Oge ọgwụgwọ ọ na-abụkarị 6 ụbọchị. N'ime ọmụmụ ụlọ ọgwụ, ndị ọrịa nwere nkwarụ angina pectoris / myocardial infarction na-enweghị Q ife Fraxiparin ka etinyere yana acetylsalicylic acid na dose nke 325 mg / ụbọchị. Ntụziaka maka ojiji na-akwado ka a ga-enye ọgwụ izizi dị ka otu ntụtụ bolus intravenous, a na-enye usoro onyonyo ndị ọzọ s.c. Emebere ọgwụ a dabere na ịdị arọ ahụ na ọnụego 86 anti-XA IU / kg.
• N'ime ọgwụgwọ nke thromboembolism, ọgwụ anticoagulants (na-enweghị contraindications) ka a ga-edepụtara ozugbo enwere ike. Usoro ọgwụgwọ ahụ anaghị akwụsị ruo mgbe ebumnuche nke prothrombin oge egosi. A na-enye ọgwụ ọgwụ s / c ugboro 2 n'ụbọchị (awa 12 ọ bụla), oge ọ na-agụ ya bụ ụbọchị iri. Ọgwụ a dabere na ịdị arọ nke onye ọrịa na ọnụego 86 anti-XA ME / kg body body.

Ntụziaka pụrụ iche

Etinyekwala ọgwụ gị ogwu!

N'ime ndị ọrịa nwere oke ọbara ọgbụgba, ịnwere ike iji ọkara nke ọgwụ a tụrụ aro ya.

Ọ bụrụ na oge nyocha a na-adịte karịa awa anọ, enwere ike ịnwe obere obere nke ọgwụ ahụ.

N'ime ndị ọrịa agadi, anaghị achọ mmezi dose (ma ewezuga ndị ọrịa nwere ọrụ mgbazigharị nsogbu). Tupu ịmalite ọgwụgwọ na Fraxiparin, a na-atụ aro iji nyochaa ndị na-egosi ọrụ arụmọrụ.

N'ime ndị ọrịa nwere nsogbu gbasara obere aha na obere ịgba alụkwaghịm (CC ≥ 30 ml / min na

Nyocha 3 maka “Fraxiparin”

Mgbe cesarean ha bidoro imere m ya, n’ụbọchị nke abụọ, oke nfụkasị bidoro n’ebe a na-agba ya, a ga-ewepụrịrị ya - mana ọ naghị afụ ụfụ ịkwụsị ya niile.

Site na ya weghachite ya na Kleksan, ọ di nfe karie. Enweghị m ike ikwu nsonaazụ ahụ, n'ihi na agafere ule ndị ahụ mgbe m tụgharịrị gaa clexane ... mana ihe niile dị mma!

Ajụrụ m dọkịta clexane ma ọ bụ fraksiparin ka ọ dị mma karịa. Dọkịta ahụ kwuru hoo haa na fraksiparin. Ọbụlagodi ọbụlagodi n’ihi na iji ọgwụ a eme ihe n’ebe ụmụ nwanyị dị ime nọ sara mbara ma mụọ.