Enwere ọtụtụ ọgwụ na-enyere ụdị shuga 2 aka. Agbanyeghị, metformin anọwo na-ejide nkwụ n’etiti ha ruo ọtụtụ iri afọ - n’ihi ịdị elu ya na nchekwa ya. Isiokwu a na-akọwa njirimara nke iji otu n'ime ọgwụ dịgasị iche iche na metformin - Metformin - Richter.

Ndabere nke ọgwụ Metformin-Richter bụ metformin onyinye, nwere nke biguanides. A na - achọpụta mmetụta hypoglycemic nke metformin ozugbo n'ihi ọtụtụ ụdị omume:

igbochi nnabata glucose si na ngha,
igbochi njikọ nke glucose na mkpụrụ ndụ akwara (ọgwụ a na --ebelata mmetụta a na 30%),
ịba ụba nke uru ahụ dị na insulin (karịa na akwara karịa ka anụ ahụ adipose).

Na mkpokọta, metformin nwere mmetụta bara uru na ọtụtụ usoro metabolic na ahụ, na-enyere aka belata ego nke cholesterol "ọjọọ" n'ime ọbara, nwere mmetụta fibrinolytic, na-achịkwa oke homonụ na-akpali akpali na ahụ, na-egbochi thrombosis.

Metformin anaghị emetụta njikọ nke insulin na pancreas, yabụ etu insulin ọ na-emepụta na-adịgide. Nke a pụtara na metformin anaghị enye aka na oke ibu, na ọdịiche insulin parenteral. Site n'iji metformin eme ihe mgbe niile na ndị ọrịa, a na-ahụta njigide dị arọ. Mmetụta Fibrinolytic bụkwa ihe e ji mara metformin. Na mgbakwunye, enweghị ekpughepịa ihe a na-apụta ya bụ na akụrụngwa nke anụ ahụ anaghị ebelata ka oge na-aga. N'adịghị ka biguanides ndị ọzọ, metformin nwere ntakịrị ihe ize ndụ nke ịmalite ọrịa lactic acidosis. Ọzọkwa, site na iji monotherapy, metformin adịghị eduga hypoglycemia, ọbụlagodi ma a exceedụọ ọgwụ ya.

Mlọ ọgwụ

Usoro ndu ogwu ahu bu 50-60%. A na-ahụta ndọrọndọrọ elekere elekere abụọ na abụọ ka ijikwa nlekọta. A na-ekesa Metformin na akwara ma ọ dịghị agbanye na protein ndị dị na plasma. Ọ nwere ike banye n’ime sel ọbara. Nnọọ obere metabolized, kpụrụ akụrụ kachasị. Oge iwepu ọkara ndụ bụ awa 6.5. Usoro ọgwụ ọgwụ nke ụmụaka dị ka ndị okenye. Ọ bụrụ na arụ ọrụ ezughi oke ọrụ, nchịkọta ọgwụ nwere n'ahụ ahụ ga-ekwe omume.

Ihe ngosipụta kachasị maka iji Metformin-Richter bụ ọrịa shuga nke 2, ya bụ, ọrịa shuga na-abụghị insulin. Site na ụdị ọrịa shuga a, ọ nweghị mbelata na mmepụta nke insulin site na mkpụrụ ndụ nke pancreas, na agbanyeghị, mmetụ nke anụ ahụ na - emetụta insulin na-ebelata, mmepụta glucose site na mkpụrụ ndụ imeju na-amụba.

Na nmalite ọrịa shuga, ọ ka mma iji usoro ọgwụgwọ na - abụghị ọgwụ ịgwọ ọrịa - nri, mmega ahụ, oke ibu. Agbanyeghị, ọ bụrụ na usoro ndị dị otú a anaghị eweta nsonaazụ, mgbe ahụ ka edepụtara ọgwụ. Nke mbụ, ọ bụ metformin. N'okwu a, a na-edozi nri.

Ọzọkwa, enwere ike inye Metformin-Richter ọgwụ maka ndị nwere nnabata glucose dị ala (proilaria) dịka prophylactic. Agbanyeghị, n'ọtụtụ ọnọdụ yana ọrịa shuga, nri na mmega ahụ dị irè karịa ị medicationụ ọgwụ.

Metformin bụ usoro ọgwụgwọ mbụ maka ọrịa shuga. Enwere ike iji ya mee ihe dị ka ọgwụ naanị yana akụkụ nke ọgwụgwọ siri ike.

Mgbe ụfọdụ, a na-ejikwa metformin gwọọ ọrịa ndị ọzọ, dịka ọrịa akwara polycystic ma ọ bụ oke ibu. Agbanyeghị, ọgwụ gọọmentị akwadoghị ojiji nke metformin ịlụ ọgụ maka oke ibu.

Mpempe mwepụta

Enwere ọtụtụ ọgwụ nwere metformin na ahịa. Metformin-Richter bụ ụdị dị iche iche nke ọgwụ nke ụlọ ọrụ ndị Hungary bụ Gideon Richter mepụtara. A na - ewepụta naanị usoro onunu ogwu nke ọgwụ - mbadamba. Mbadamba ụrọ nke ọ bụla nwere 500 ma ọ bụ 850 mg nke ihe arụ ọrụ.

Ndi ozo bu nke Metformin-Richter mbadamba:

copovidone
polyvidone
microcrystalline cellulose,
silica
stereta magnesium.

Ọ dị mma ịmara na mbadamba 500 mg abụọ abụghị otu mbadamba 850 mg. Enwere ike ịzụta ọgwụ ahụ n'ụlọ ahịa ọgwụ na-enweghị ndenye ọgwụ.

Ihe ngbanwe

Metformin Richter nwere contraindications ole na ole. Hapụrụ ọgwụ maka ụmụaka site na afọ 12. Agbanyeghị, n’oge ime na inye nwa ara, a naghị atụ aro ọgwụ a. Ihe ozo di nkpa contraindication bu odida nke akwara (mwepu nke okike erughi 60 ml / min). Ebe ọ bụ na akịrị wepụrụ ọgwụ ahụ n'ahụ site na akụrụ, ọdịda akụrụ nwere ike ibute nchịkọta nke ọgwụ ahụ n'ime ahụ, nke a pụta na nsonaazụ na-adịghị mma, nke a kọwara n'okpuru ebe a "ngalaba" oke.

Metformin-Richter na-contraindicated na:

ọrịa shuga na precoma,
ọrịa mamịrị ketoacidosis,
nnukwu myocardial infarction,
nnukwu obi adaa,
nnukwu akụkụ okuku ume na okuku
akpịrị ịkpọ nkụ
ọrịa na-efe efe siri ike
lactic acidosis (gụnyere akụkọ ihe mere eme)
egbu egbu egbu
usoro nyocha iji ọgwụ ayodiin nwere ayodiin (ụbọchị abụọ tupu usoro ahụ yana ụbọchị 2 ka ọ gasịrị),
A na - ahụkarị ogwugwo ahụ (ụbọchị abụọ tupu usoro ahụ yana ụbọchị abụọ ka emechara).
ụkọ lactase na ekweghị n ’lactose.

You nweghị ike ị takeụ ọgwụ a nye ndị na-eri nri nwere kalori (erughi 1000 kcal / ụbọchị)

N'iji nlezianya dọọ, Metformin-Richter ka edepụtara maka ndị okenye (karịa afọ 60) na-arụ ọrụ arụ ọrụ siri ike. Ejikọtara nke a na oke ihe egwu nke lactic acidosis na otu ndị ọrịa. Na nsogbu ọrịa metabolic siri ike, achọrọ mbelata dose.

Metformin Richter 500, 850, 1000: ntuziaka, nyocha, ntụnyere

N'ọtụtụ ọnụọgụ, battanides ka edepụtara ka ọ bụrụ ọgwụ izizi maka ndị ọrịa nwere ọrịa mellitus. Metformin-Richter bụ otu n'ime ọtụtụ ọgwụ metụtara ogo a nke ndị ọrịa hypoglycemic. E mepụtara mbadamba ahụ site na alaka ụlọ ọrụ Russia nke ụlọ ọrụ ndị Hungary Gideon-Richter, nke bụ otu n'ime ndị na-emepụta ọgwụ Europe kachasị ukwuu.

A kọwara ụdị ewu ewu nke metformin site na oke arụmọrụ ya na mmalite ọrịa ahụ, ọnụọgụ nke nsonaazụ ndị ọzọ, nsonaazụ dị mma na sistem obi yana oke ibu nke ndị ọrịa mamịrị. Agbanyeghị usoro ọgwụgwọ ọdịnala ma ọ bụ nke dọkịta gị na-eme, ozugbo nchọpụta nke ọrịa shuga, ọ ga-edepụta usoro nri, mmegharị na metformin.

Ihe omuma banyere ogwu

Metformin Richter dị n'ụdị nke mbadamba ọcha ọcha. Onye rụpụtara ya bụ ụlọ ọrụ ụlọ GEDEON RICHTER-RUS CJSC. Otu mbadamba 1 nwere metformin hydrochloride, yana talc, magnesium stearate na ọka ọka na obere. E mepụtara ha na usoro dị iche iche: 500 mg, 850 mg na 1000 mg.

Onye na - ahụ maka ọrịa hypoglycemic nwere ike ịkọwa ya site na endocrinologist maka ọrịa shuga nke 2, ọ bụrụ na onye ọrịa adịghị adịkarị mmepe mmepe nke ketoacidosis, yana yana yana inulin na insulin. A na-ewere ọgwụ ahụ na adịghị ike nke nri edoziziri na agụmakwụkwọ anụ ahụ.

Mgbe onye ọrịa na-ewere mbadamba Metformin Richter, ha na-abanye na ngọngọ nri. Drawepụta ọgwụ ọjọọ emee site na akụrụ na-agbanweghi. Ihe ogwu nke ogwu a bu:

Mbelata glucose na umeji.
Mbelata nke ịba uru nke glucose.
Mbelata mgbasa nke homonụ na-akpali akpali n’ime ọbara ọbara.
Ihe mgbochi nke glucogenesis - usoro ịkpụkọta glucose na imeju.
Increbawanyewanye uru anụ ahụ dị na insulin homonụ.
Ikelatalatara iji mepụta mkpụkọ ọbara.
Kachasị usoro nke resorption nke egbochi mkpụkọ ọbara.
Mbelata triglycerides, yana linoproteins dị ala.
Igha nkpuru nke nwere abuba acid.
Mbelata nke ịta cholesterol.

Na mgbakwunye, iji ọgwụ ahụ eme ka ahụ sie ike ma belata oke ahụ.

Ntuziaka maka mbadamba mbadamba

Enweghị ike ịzụta ọgwụ a na-enweghị ndenye ọgwụ dọkịta. Usoro ị theụ ọgwụ ahụ nwere ike ịdị iche iche dabere n'ọbara shuga dị n'ọbara, ogo ọrụ ya, ọrịa nje na ọdịmma onye ọrịa. Mgbe ịzụta Metformin Richter, a ga-eji nlezianya mụọ ntuziaka onye ọrịa.

A na-ahapụ ndị ọrịa shuga na-aga ọgwụgwọ iji ọgwụ ike were ọgwụ ruru narị ise ruo otu puku. Ka izu abụọ nke ọgwụgwọ ahụ gasịrị, ọ ga-ekwe omume ịba ụba na onunu ogwu. Amachibidoro ịchọrọ ịbawanye oke nke ọgwụ a, naanị dọkịta nwere ike jiri nlezianya nyochaa ohere nke ịbawanye ya.

Ọ dị mkpa ka ndị agadi wepụta 1000 mg kwa ụbọchị. A na-ahụta usoro ọgwụgwọ mmezi dị ka 1500 mg ruo 2000 mg. N'otu oge, ihe ruru 3000 mg nwere ike iri oke karịa kwa ụbọchị. N'ime ntinye ahụ etinyere ya, a na-adụ ya ka ị takeụọ ọgwụ n’oge ma ọ bụ mgbe nri ahụ gasịrị, na-a theụ mbadamba mmiri ndị ahụ.

Okwesiri iburu n’uzo na iwere Metformin Richter, ihe mmeghachi omume nke aru bu omume. E jikọtara ha na ihe riri ahụ na mmemme nke ihe na-arụ ọrụ. Izu abụọ mbụ, onye ọrịa nwere ike mee mkpesa maka iwe nri, ya bụ ọgbụgbọ, afọ ọsịsa, mgbanwe nke uto, enweghị agụụ, ịba ụba gas, afọ ime. Dị ka ọ na-eme, mgbaàmà ndị a na-apụ n'anya nke aka ha. Iji belata ogo mmeghachi omume ọjọọ, a ga-ekewa ọgwụ ahụ n'ọtụtụ oge.

Ekwesịrị ịchekwa Metformin Richter site na iru mmiri, n'akụkụ ụmụaka. Okpomoku ekwesighi iga +25 Celsius.

Afọ abụọ site na ụbọchị ịhapụ ọgwụ ahụ, amachibidoro nchịkwa ya.

Mkparịta ụka ọgwụ ndị ọzọ

E nwere ọgwụ dịgasị iche na mmetụta ha na ọgwụgwọ nke ọgwụ ndị ọzọ. Yabụ, ụfọdụ n'ime ha belata mmetụta hypoglycemic nke Metformin Richter, si otú a na-ebute mmụba na ọkwa shuga. Ndị ọzọ, n'ụzọ megidere, na-eme ka mmetụta nke ọgwụ ahụ dịkwuo elu ma nwee ike iduga n'ịbelata glucose dị ala.

Yabụ, mkpokọta akwadoro na Metformin Richter, nke nwere ike ibute hyperglycemia, bụ Danazol, glucocorticosteroids, contraceptives, epinofrin, “loop” na thiazide diuretics, sympathomimetics, homonụ thyroid, nicotinic acid na phenothiazineeri, yana chlorproma.

Nlekọta oge nke Metformin Richter na ACE na MAO inhibitors, sulfonylurea na clofibrate, NSAIDs, oxytetracycline, cyclophosphamide, insulin, acarbose na beta-blockers na-eme ka ohere nke shuga dị ukwuu belata.

Na mgbakwunye, site na iji ihe ọholicụholicụ na-egbu egbu n'oge ọgwụgwọ ọgwụ, mmepe nke lactic acidosis ga-ekwe omume, karịsịa ma ọ bụrụ na onye ọrịa ahụ esoghị na-eri nri. Cimetidine nwekwara ike ime ka ohere nke lactic acidosis nwee ụdị shuga nke 2, ebe ọ na-ebelata akụkụ nke ọgwụ ahụ na-arụ ọrụ.

Iji gbochie nsonaazụ ndị dị otú a, ekwesịrị ka gị na ndị ọkachamara na-abịa ya, nwee ike gụọ nkọwa nke ọgwụ ahụ na ntuziaka ndị agbakwunyere.

Ahịa, nyocha na analogues

Onye ọrịa ahụ, na-enweta otu ọgwụ, na-elekwasị anya ọ bụghị naanị na ọgwụgwọ ọgwụgwọ ya.

Ebe ọ bụ na ọnụ ọgụgụ ndị bi na ya nwere ego dị iche iche, onye ọ bụla nwere ike ị nweta ọgwụ ọgwụ ike ha niile. Costgwọ ọgwụ ọjọọ ahụ dịgasị iche dabere na usoro nke isi ihe na-arụ ọrụ dị na ya.

Ọnụ ego nke Metformin Richter:

500 mg (mbadamba 60 kwa mkpọ): ọnụahịa si na 165 ruo 195 rubles,
850 mg (mbadamba 60 kwa mkpọ): ọnụahịa sitere na 185 ruo 250 rubles,
1000 mg (mbadamba 60 kwa mkpọ): ọnụahịa sitere na 220 ruo 280 rubles.

Nyocha nke ndị ọrịa mamịrị na ndị dọkịta dị mma. Metformin Richter na - enyere aka igbochi ọrịa shuga mgbe a chọpụtara onye ọrịa ọrịa ala. Ọgwụ na -ebilata ogo shuga. Nsonaazụ ndị ọzọ, na mgbakwunye na afọ mgbu, anaghị egosipụta nke ọma. Ọgwụ na-enyekwara aka funfu ego ole na ole.

Mgbe ụfọdụ enwere ike iji Metformin Richter n'ihi ọnụnọ nke contraindications ụfọdụ, yana ọdịdị nke mmeghachi omume na-adịghị mma. N'okwu a, dọkịta ahụ nwere ike inye onye ọrịa ọgwụgwọ ọzọ ụdị ọgwụgwọ ahụ. Ebe ọ bụ na metformin bụ ihe ama ama hypoglycemic na-elekọta mmadụ n'ụwa niile, enwere ọtụtụ ọnụọgụ ọgwụ nwere ihe a mejupụtara. Ihe dị iche na ụzọ nwere ike ịbụ naanị ọdịnaya nke ndị ozu. Ọgwụ Metformin Richter nwere usoro analo ndị a nke onye na-ere ọgwụ nwere ike igosi na ụlọ ahịa ọgwụ ọ bụla na mba ahụ, nkwadebe ahụ nwere ike ịdị iche na otu ihe mejupụtara ya ma bụrụ otu.

Gliformin (500mg Nke 60 - 108 rubles).
Glucophage (500mg Nke 30 - 107 rubles).
Metfogamma (850mg Nke 30 - 130 rubles).
Metformin Teva (500mg Nke 30 - 90 rubles).
Mpempe akwụkwọ (500mg Nke 30 - 73 rubles).
Siofor (500mg Nke 60 - 245 rubles).
Metformin Canon (500mg Nke 60 - 170 rubles).
Metformin Zentiva (500mg Nke 60 - 135 rubles).

Ejiri ọgwụ analogues ndị a dị n'elu maka ọrịa shuga na-abụghị insulin, ihe dị iche bụ naanị na contraindications na mmerụ ahụ. Iji ezigbo ojiji, ị nwere ike nweta mbelata na idozi ọkwa glucose, na Metformin Richter anaghị enweta oke mmetụta.

Vidiyo dị n'isiokwu a, enyere n'okpuru, ga-ekwu banyere njirimara ọgwụ nke Metformin.

Mbadamba ụrọ Metformin Richter

Ọgwụ maka ndị ọrịa mamịrị dị na ụdị mbadamba atọ nke 500 ma ọ bụ 850 mg nke metformin: biconvex, okirikiri, oblong na shei ọcha. Na ngwugwu nke iberibe iri. A na-enye ọgwụ ọgwụ site na ọgwụ ọgwụ dịka ọgwụ nke ndị dibia bekee si kwu.

Ihe mejupụtara ọgwụ ahụ nwere ihe ndị na-ere shuga n'ime ahụ, na-eme ka ọdịmma onye ọrịa dị mma:

colloidal silicon dioxide - 2%, microcrystalline cellulose - 98%

White Opadrai II

hypromellose - 40%, titanium dioxide - 25%, lactose monohydrate - 21%, macrogol 4000 - 8%, triacetin - 6%

Pharmacodynamics na pharmacokinetics

Ọgwụ nke ìgwè biguanide na-ebelata shuga ọbara. Were ogwu gwaa ogwu dika ntuziaka a si di. A na-egbochi usoro ịmịnye glucose na imeju site na 30% na elu, ebe nzuzo nke homonụ ndị ọzọ agbanwebeghị. Nke a na-eduga n'ịbelata ihe ndị na-enye carbohydrate.

Ihe ozo nke ogwu a bu ihe mgbochi nke carbohydrates na mwepu ya nke ozo n’enye ya n’ime plasma. A na-eji ọgwụ hypoglycemic dị ka ụzọ maka ifelata, mana ikwesighi ịhapụ nri dị ala. Ngwá ọrụ na-eme ka usoro nke oxidation nke abụba ọdụdụ, na-egbochi biosynthesis nke cholesterol, na-eme ka ahụ nwee insulin.

Iji ọgwụ a na-eme ihe kwa ụbọchị na-eme ka ị ghara ibu ibu. N'ihi nke a, ọgwụ a na-ewu ewu n'etiti ndị nwere ọrịa shuga 2 bụ ndị buru oke ibu. Mgbe ị na-achịkwa, metformin bụ eriri afọ na-agbasa, ọdịnaya nke arụ ọrụ kwesịrị ịdị tupu oge awa 2-3.

A na-ekesa ọgwụ ahụ n'ụzọ na-ezighi ezi, a na-ahụta ebe a na-eleba anya na akwara anụ ahụ, imeju, gland na mbuba na akụrụ.A na - ekepụta ngwaahịa ahụ site na ọrụ nke usoro ọgwụgwọ ma ọ bụ nke a na - eme n'ime awa 1-4, dabere na njirimara nke anụ ahụ.

Ngwakọta na ịhapụ ụdị

Ọgwụ (1 tab.) Nwere naanị metformin umi na-arụ ọrụ, akụkụ ya nwere ike ịbụ 500 mg na 850 mg. A na-egosiputa ihe ndi ozo:

Magnesium Stearate
Polyvidone
Aerosil
Copovidone
MCC.

500 mg na ọgwụ ogwu 850 bụ nke elongated, na-acha ọcha. A na-etinye mbadamba na blisters nke 10 PC. N'ime ngwugwu ahụ enwere blister 5.

Ngwongwo na-agwọ ọrịa

N'okpuru mmetụta nke metformin, a na-ahụ na igbochi gluconeogenesis na mkpụrụ ndụ imeju, a na-ebelata nnabata nke glucose site na mgbidi eriri afọ, usoro a na-eji ya eme ihe. N'otu oge ahụ, mmụba nke ike nke anụ ahụ na ime ihe insulin na-edekọ na-enweghị emetụta mmepụta nke insulin site na mkpụrụ ndụ located-nke dị na pancreas, n'ihi nke enwere ike belata cholesterol, LDL, na triglycerides n'ọbara.

Isi ọgwụ ọgwụ ọgwụ gosipụtara bụ:

Kachasịsịsịsịsịsịsị usoro nke mgbagha mgbaru ọsịị na mbelata nke mkpụkọ umeji
Regulation nke ọkwa thyroid na-akpali akpali
Ihe mgbochi nke gluconeogenesis
Mbibi nke thrombosis
Meziwanye usoro nke resorption nke egbochi mkpụkọ ọbara
Mbelata linoproteins na triglycerides
Cenweta ọnya nke otutu nke abụba
Normalization nke cholesterol.

Mgbe eji mbadamba ụrọ, enwere nnabata ngwa ngwa ihe na-arụ ọrụ nke eriri afọ. Ihe ngosi bioavisible kariri 60%. A na-edekọ mkpokọta plasma kachasị elu mgbe awa 2.5 gachara. Mgbe ị na-eri nri, a na-ebelata ogo a site na 40% na ihe ọ rụpụtara na-egbochi ihe dị ka nkeji iri atọ na ise.

A na-eji Metformin mara maka nkesa ngwa ngwa n'ime akwara, yana usoro metabolic dị ala. Mmekọrịta metformin na protein plasma dị ntakịrị.

A na-ewepu usoro mkpochapu site na ntinye nke sistem. Ọ dị mma ịmara na ọkara ndụ ahụ bụ awa 6.5.

Metformin Richter: ntuziaka zuru oke maka ojiji

Ọnụahịa: site na 162 ruo 271 rubles.

Iri nri riri oke nri ma obu ozugbo. E kwesịrị iji mmiri mmiri were were sachaa ọgwụ. Iji belata ohere nke ịmalite ịrịa ọrịa na-adịghị mma, m na-a drinkụ ihe ọ dailyụ theụ kwa ụbọchị maka 2-3 r.

A na-ekpebi usoro ị drugsụ ọgwụ ọjọọ n’otu n’otu n’inwe ndekọ glucose.

Ceptionnabata ọgwụ ị withụ ọgwụ ọ bụla nke milligram 500: bido gwọọ ya kwa ụbọchị nke 0-1-1 g. ịba ụba usoro onunu ogwu mgbe enwere ike ịchịkwa glucose. Ọtụtụ mgbe, usoro mmezi kwa ụbọchị anaghị agafe 1.5-2 g, nke kachasị - 3 g.

Ojiji nke mbadamba ogwu nwere ogwu nke 850 milligrams: n'ime ubochi mbu nke ọgwụgwọ, a na-atụ aro ka ị were 850 mg nke metformin kwa ụbọchị. Mgbe ụbọchị 10-15 gachara. dọkịta gị nwere ike ikwu ka iwelie ọgwụ gị. N'oge ọgwụgwọ mmezi, a na-ewere usoro metformin kwa ụbọchị na ọnụọgụ 1.7 g. Usoro ọgwụgwọ kachasị elu ekwesịghị gafere 2.55 g.

Adịghị akwado ndị ọrịa agadi ka ha rie ihe karịrị 1 g nke metformin kwa ụbọchị.

N'ihe banyere nnukwu nsogbu metabolism, enwere ike nke lactic acidosis na-abawanye, nke a ga-achọ mbelata usoro ị theụ ọgwụ ahụ.

Mkparịta ụka ọgwụ ọjọọ

Enwere mmụba na mmetụta hypoglycemic n'oge a na-eme n'otu oge:

Ndị na-egbochi ya
NWPS
Nkwadebe dabere na usoro sulfonylurea, clofibrate
Ndị na - egbochi ACE na MAO
Acarbose
Cyclophosphamide
Oxytetracycline
Insulin.

E dere mbelata nke mmetụta hypoglycemic n'oge eji ọgwụ ndị na-esonụ:

COC
Sympathomimetics
Homonụ thyroid
GKS
Ngwakọta nke phenothiazine yana acid nicotinic
Epinephrine
Difọdụ mkpụrụ mmiri ("akaghị" na otu ìgwè thiazide)
Glucagon.

Cimetidine nwere ike igbochi mkpochapụ nke metformin, nke na-abawanye ohere nke lactic acidosis.

Site na iji ọgwụ anticoagulants na-eme n'otu oge, mmetụta nke ọgwụ ndị dabere na metformin nwere ike ibelata.

Alcoholakingụ mmanya na ọgwụ ethanol nwere ike ibute mmepe nke lactic acidosis.

Nsonaazụ

Enwere ike gosipụta nsonaazụ mgbe ị na-a drugụ ọgwụ ahụ na mmeghachi omume nfụkasị, nsogbu nri, ọgbụgbọ, ọgbụgbọ, ekpomoku, ụtọ ọla. Ihe ịtụnanya ndị a na - eme ugboro ugboro ma na - apụta ihe karịrị 1 mmadụ n’ime mmadụ iri n’afọ iri na - abụkarị, ụdị ihe ịtụnanya a na - eme na mbido usoro ọgwụgwọ ma nwee ike ibunye nke ha. Na mgbakwunye, mmụba na-adịghị ala ala, dịka iwu, na-enyekwa aka iwepu nsonaazụ ndị ọzọ. Site na ihe ijuanya na-adighi nma nke metụtara eriri afọ, a na-atụ aro ị anụ ọgwụ anticholinergics, antacids ma ọ bụ antispasmodics.

A na-ejikọkarị hypoglycemia dị ka akụkụ ọ na-agakọ na oge nke ọgwụ ndị ọzọ. Enyere ndepụta nke ọgwụ ndị a na ngalaba “Mmekọrịta na ọgwụ ndị ọzọ”. Lactic acidosis, dị ka ihe mmetụta dị n'akụkụ, na-aputa ya oke oke. Ọtụtụ mgbe, nsonaazụ a na-egosi na ndị mmadụ na-ata ahụhụ n'ihi ọrụ ezumike ezumike. Mmetụta dị n'akụkụ a chọrọ ịkwụsị ọgwụgwọ ozugbo.

Site na ọgwụgwọ ogologo oge, ụkọ vitamin B12 ga-ekwe omume n'ihi mmebi nke mmịkọ ya na eriri afọ, megaloblastic anaemia. Enweghi mmụba nke transpeases na ịba ọcha n'anya. Ihe ịtụnanya ndị a na - apụ n'anya mgbe ịkwụsị ọgwụ.

Mmetụta nke ọgwụ ahụ na mmeghachi omume psychomotor

Monotherapy na ọgwụ ahụ anaghị emetụta sistemụ akwara. Ya mere, ọ bụrụ na e bupụrụ onye ọrịa naanị metformin, onye ọrịa ahụ nwere ike nwee ike kwọrọ ụgbọ ma ọ bụ rụọ ọrụ chọrọ ịta ahụhụ. Agbanyeghị, mgbe ị na-eji ọgwụ ndị ọzọ (usoro sulfonylurea, insulin), mmeghachi omume hypoglycemic ga-ekwe omume. A naghị atụ aro ka ndị ọrịa dị otú a tinye aka na ọrụ ndị a dị n'elu.

Dodoụbiga ya ókè

Ọbụlagodi mgbe usoro ọgwụgwọ ọgwụgwọ gaferela okpukpu iri, ndị ọrịa anaghị ahụ ụdị ihe ahụ dịka hypoglycemia. Kaosinadị, n'ihe fọrọ nke nta ka ọ bụrụ na nke a, ọnọdụ nke lactic acidosis ga - eme - oke ngbanwe kachasị nke ịhapụ lactic acid n'ime ọbara. Ọnọdụ a dị oke egwu ma nwee ike igbu egbu na enweghị ọgwụgwọ kwesịrị ekwesị. Mgbaàmà nke lactic acidosis:

olu mgbu
akwara mgbu
dyspepsia
ibelata na ahụ ọkụ
ọnwụ nke nhazi
ịkụda mmụọ
na-ebelata ọbara mgbali elu
bradycardia.

Enweghị nlekọta ahụike, Coma na-amalite ma nwụọ. Ọgwụgwọ na lactic acidosis nwere ike ibute naanị n’ụlọ ọgwụ. Usoro ọgwụgwọ, usoro ọgwụgwọ Symptomatic ka akwadoro.

Iji gbochie nsogbu a mgbe ị na-ewere Metformin-Richter, ọ dị mkpa ịlele ntinye ọbara maka lactic acid ugboro abụọ n'afọ. Ekwesịrị icheta na ihe ize ndụ nke lactic acidosis na-abawanye na ị ofụbiga mmanya ókè, nri nwere obere kalori yana ọrụ imeju na-arụ ọrụ. Lactic acidosis nwekwara ike ime mgbe ewere iodine nwere ihe dị iche iche nwere.

N'ime ndị agadi, a ga-enyocha ọkwa nke creatinine ọbara kwa oge iji chọpụta mbelata ọrụ ọrụ akụrụ n'oge, n'ihi na ọnọdụ a nwekwara ike itinye aka na nchịkọta nke metformin n'ọbara na oke onunu ya. A gha eme ihe a ugboro abụọ n’afọ.

Mmekọrịta na ọgwụ ndị ọzọ

Ekwesighi iji ọgwụ a mee ihe na mmanya iji mee ka ọ dịkwuo njọ n'ihi lactic acidosis. Otu ihe a metụtara ị cimụ cimetidine. Ọzọkwa, ụfọdụ ọgwụ na-eme ka mmetụta nke metformin gbanwee ma nwee ike iduga hypoglycemia. Otu a gunyere:

cyclophosphamide
MA inhibitors
Ihe mgbochi ACE
Ndị NSAID
ihe mgbochi beta,
eji eme ugba mmuo
insulin
salicylates,
acarbose,
Ọkpụkpụ oxygen

Ihe mgbochi oral, glucocorticosteroids, epinephrine, homonụ thyroid, ọgwụ nicotinic acid, ọgwụ ọmịiko, akwara na-ebelata ịdị irè nke metformin.

N'aka nke ya, metformin na-ebelata ike ọrụ ndị na-apụta coumarin.

Iodine nwere ihe dị iche na - emetụta mmadụ nwere ike ibute nchịkọta nke metformin.

Kedu ka ọgwụ ahụ si arụ ọrụ?

Metformin bụ ọgwụ bụ ọgwụ enyere ndị ọrịa shuga ozugbo na ndụ. Ihe kpatara nkwenye ndị dọkịta na ọgwụ a dabere na nsonaazụ ya:

Metformin nwere nrụpụta ọrụ hypoglycemic dị elu nke na-enweghị atụ nke sulfonylureas. Ebumnuche ya na-enye aka belata hemoglobin glycated site na nkezi nke 1.5%. A na - achọpụta nsonaazụ kacha mma na ndị ọrịa mamịrị.
A gwakọtara ọgwụ ahụ nke ọma yana ọgwụ ndị ọzọ edepụtara maka ọrịa shuga. Usoro ọgwụgwọ abụọ na atọ nwere metformin nwere ike nweta njikwa ọrịa shuga n'ọtụtụ ndị ọrịa.
Ọgwụ nwere akụrụngwa pụrụ iche. E gosiputara na iwere ya na –ebelata ohere nke nkụchi obi, na - ebughari mmeghari akwara.
Metformin bụ otu n'ime nchekwa ọgwụ antidiabet kasị dịrị nchebe. Ọ fọrọ nke nta ka ọ ghara ibute hypoglycemia, a na-edekọ mmetụta ndị ọzọ dị ize ndụ dị oke ala.

Mmetụta na-ebelata shuga nke Metformin-Richter bụ nsonaazụ nke ọrụ ọtụtụ usoro, ọ dịghị nke ọ bụla n'ime ha na-emetụta njikọ insulin. Mgbe ị takingụ ọgwụ ahụ, imeju na - emeju glucose site na umeji n'otu oge, ebufe ya na anụ ahụ na - aka mma n'ihi mbelata nguzogide insulin. Ntụziaka maka iji rịba ama na nsonaazụ ndị ọzọ nke metformin na-enye aka na njikwa nchịkwa nke ọrịa mellitus - na -ebelata oriri nke carbohydrates site na eriri afọ, yana ibelata agụụ. Dika nyocha, ihe a nwere ike ikwado usoro nke ifelata na oria shuga.

Ihe ngosi maka ojiji

Na nyocha nke ndị dọkịta, a na-akpọkarị metformin ntọala maka ịgwọ ụdị ọrịa shuga 2. Ntuziaka banyere ụlọ ọgwụ ụwa na nke Rọshịa kwenyechara na nkwupụta a. Acheszọ maka ọgwụgwọ na-agbanwe, ọgwụ ọhụrụ na ụzọ ịchọpụta ọrịa na-apụta, mana ebe nke metformin ka na-agbanwe agbanwe.

Edere ọgwụ ahụ:

Ndị niile nwere ọrịa shuga maka inye ndụmọdụ na-enye ihe na-edozi ahụ anaghị enye glycemia ezubere iche.
Ozugbo achọpụtara ọrịa shuga, ọ bụrụ na nnwale ahụ gosipụtara mgbochi insulin dị elu. Enwere ike iche na ya na ndị ọrịa nwere nnukwu ibu.
Dị ka akụkụ nke ọgwụgwọ nke ndị ọrịa mamịrị nwere ogologo ọrịa.
Na ọrịa shuga na-akpata insulin, iji belata insulin.
Ndị ọrịa nwere ọrịa metabolic, ọgwụ ibu dị ka mgbakwunye na mgbanwe ndụ.
Ndị na-ebu oke ibu ma nwee nnukwu ọrịa shuga. Site na ibelata insulin iguzogide, Metformin Richter na-abawanye ịdị irè nke nri.

Ka ọ dị ugbu a, enwere ihe akaebe banyere enwere ike iji ọgwụ maka polycystic ovaries na steatosis imeju, mana etinyebeghị akara ndị a na ntuziaka ahụ.

Mmetụta ndị na-achọghị ka metformin

Isi mmetụta metformin nwere njikọ na nsonaazụ ya na nri nri site na afọ na oke nke eriri afọ, nke usoro mgbaze bụ isi na-apụta. Ọrịa ndị a adịghị ize ndụ maka ahụike, mana na-eme ka nnabata nke ọgwụ ahụ dịkwuo njọ ma na-eme ka ọnụ ọgụgụ ndị na-ajụ ọgwụgwọ pụta n'ihi ahụike nke ndị ọrịa.

A na-ahụta nsonaazụ na eriri afọ na mbido ọgwụgwọ nke Metformin-Richter na 25% nke ndị ọrịa mamịrị. Enwere ike gosipụta ya na ọgbụgbọ na ụtọ ọla na ọnụ na-enweghị afọ, vomiting, afọ ọsịsa. Mmetụta a na-achọghị bụ dose-dabere, ya bụ, ọ na-eto n’otu oge yana mmụba na usoro onunu ogwu. Mgbe izu ole na ole gasịrị, eriri afọ na-emegharị ahụ na metformin, ọtụtụ ihe mgbaàmà ahụ na-agwụ ike ma ọ bụ na-apụ n'anya.

Nyocha nke ndị na-arịa ọrịa shuga na-egosi na ị timeụ ọgwụ n'otu oge ahụ dị ka nri siri ike na-enyere aka belata mgbaàmà, na-ekewa ụbọchị kwa ụbọchị n'ime usoro 3, ma jiri nwayọ na-abawanye usoro onunu ogwu malite na nke kacha nta (500, kacha 850 mg).

Ọzọkwa, mgbe ị na-ewere Metformin-Richter na ndị ọrịa nwere ọrịa shuga, mmeghachi omume nfụkasị anụ ahụ, enwere ike ịhụ obere mmebi nke ọrụ imeju. A na-enyocha ihe ize ndụ ha dị ka ọ dị ụkọ (0.01%).

Mmetụta akụkụ mmetụta naanị maka metformin bụ lactic acidosis. Ihe gbasara nke puru omume bu oge ato n’etiti ndi oria puku ise. Iji zere lactic acidosis, ị ga-agbasochi ntuziaka maka ojiji, egbula ọgwụ ahụ ma ọ bụrụ na enwere contraindications, agafeghị usoro ọgwụ enyere.

Dọkịta nke Sciences Medical, Isi nke Institute of Diabetology - Tatyana Yakovleva

M na-amụ ọrịa shuga kemgbe ọtụtụ afọ. Ọ na-atụ ụjọ mgbe ọtụtụ mmadụ nwụrụ, nweekwa nkwarụ karịa n'ihi ọrịa shuga.

Emere m ngwa ngwa izisa ozi ọma - thelọ Ọrụ Nnyocha Ọgwụ Endocrinology nke Mahadum Ọgwụ nke Russia jisiri ike mepụta ọgwụ na-agwọ ọrịa shuga kpamkpam. N'oge a, ịdị irè nke ọgwụ a na-eru nso 98%.

Ozi ọma ọzọ: Ministri Ahụike echekwaala maka mmemme pụrụ iche nke na-akwụ ụgwọ ọgwụ dị elu. Na Russia, ndị ọrịa mamịrị ruo Mee Mee 18 (isonye) nwere ike inweta ya - Naanị 147 rubles!

Uzo esi ewere Metformin Richter

Ekwesịrị ịhọrọ usoro Metformin maka nke ọ bụla maka ọrịa mamịrị ọbụla. N'oge ahọpụtara, nkuzi a na-atụ aro ka ewere ihe nrịba glucose ugboro ugboro.

Otu esi ekpebi usoro ogwu achọrọ:

A na-ahụta oge ịmalite iji Metọdin-Richter mbadamba mbadamba 500 ma ọ bụ 850. Achọghị izu abụọ mbụ. Mbadamba ụrọ ga-eri nri abalị.
Ọ bụrụ na enweghị mmetụta ọ bụla, usoro ịba ụba na-abawanye site na 500 ma ọ bụ 850 mg kwa izu abụọ. A na-ekewa mbadamba ụzọ abụọ, wee banye na atọ. Ka ọ̀gwụ ahụ na-abawanye, glucose na-ebu ọnụ na-ebuwanye ibu, yanazie glucose kwa ụbọchị.
Usoro kachasị mma bụ 2000 mg. Mmụba na-abawanye na ọnụ ọgụgụ mbadamba ụrọ na mgbakwunye nke glycemia dị ala karịa nke mbụ.
Oke metformin na-anabata kwa ụbọchị bụ 3000 mg, maka ọrịa akụrụ - 1000 mg, na nwata - 2000 mg.

Ndị dọkịta na ndị ọrịa mamịrị gbasara ọgwụ

N'afọ ndị gafeworonụ, Metformin-Richter jisiri ike nakọta ọtụtụ nyocha dị mma na nke na-adịghị mma. N'ime ndị ọrịa nwere ọrịa shuga, ọgwụ a na-ewu ewu nke ukwuu, ebe ọ na-ebelata hyperglycemia nke ọma, na-enweghị kpatara hypoglycemia. Ha hụrụ ihe ngwa ngwa ọgwụ a mere: "n'ụzọ nkịtị site na mbadamba ihe."

A na - ewerekwa Metformin-Richter dị ka ụzọ isi gbochie agụụ, na - akpali ovulation na PCOS, na ibelata oke abụba dị n'ime ndị egwuregwu. A na-enyocha nsonaazụ ndị ọzọ nke metformin n'echeghị ọnụ. Enwere afọ ime na-atụ anya na oke ibu site na iri ruru kilogram n'ụlọ akụ. Dị ka o kwesịrị ịdị, enwere nyocha ndị na-adịghị mma. Ọtụtụ mgbe, ndị na-ede akwụkwọ ha bụ ndị weere metformin na-agwaghị dọkịta, nke a kọwara n'ụzọ dị mfe. Endocrinologists na-edepụta ọgwụ maka oke ibu naanị ndị ọrịa nwere nguzogide insulin, nke ọ bụghị mmadụ niile nwere.

Ndi dibia na achota uzo di elu nke Metformin-Richter obughi na oria n’aria aru, kama n’otutu ndi n’eme oria mmikpo n’abia. Site na ọgwụgwọ kwesịrị ekwesị na àgwà dịịrị ndị ọrịa, ọ ga-ekwe omume izere ọrịa ahụ na 75% nke ikpe.

Analogues nke ọgwụ

Ọgwụ Russia ọ bụla nwere okwu "metformin" n'aha nwere ike dochie Metformin-Richter. A na-emepụta Vertex, Medisorb, Canonfarm, Akrikhin na ndị ọzọ. Glyformin, Merifatin, Bagomet nwere otu ihe mebere. Aka nke ndị si mba ọzọ nke Metformin-Richter - French Glucophage, German Siofor na Metfogamma. Ọgwụ ndị a yiri na ikike, yabụ ị nwere ike ịgakwuru ha n’emeghị nhọrọ ọzọ.

Maka ndị ọrịa na-anabataghị mbadamba ihe, ndị dọkịta na-atụ aro kama Metformin-Richter ka ọ anaụọ ihe ọlogụ anaụ ya nke oge ọrụ na otu ihe eji arụ ọrụ: Glucofage Long, Metformin Prolong, Metformin MV.

Gbalia imuta! You chere na ị takingụ ọgwụ na insulin bụ naanị ụzọ eji egbochi shuga? Ọ bụghị eziokwu! Nwere ike ịchọpụta nke a n'onwe gị site na ịmalite iji ya. gụkwuo >>