Mpempe akwụkwọ dicinon: ntuziaka maka ojiji

Dicinon dị na mbadamba nkume ma n'ụdị ihe eji eme ka mmiri sie ike.

Ihe na - arụ ọrụ nke ọgwụ ahụ bụ ethamsylate. Ntinye uche ya na otu mbadamba bụ 250 mg, na 1 ml nke ihe ngwọta - 125 mg.

Dị ka ihe inyeaka, mbadamba Dicinon gụnyere acid citric acid, ahịhịa ọka, magnesium stearate, povidone K25, lactose.

Na mgbakwunye ethamylate, ihe ngwọta nwere sodium disulfite, mmiri maka ntụtụ, sodium bicarbonate (n'ọnọdụ ụfọdụ ọ dị mkpa iji dozie ọkwa pH).

Mbadamba mbadamba ọgwụ na mbadamba 10 n'ime blisters; a na-ere blister 10 na ngwugwu katọn. A ga-ahụta azịza maka nchịkwa intramuscular na intraus na ampoules nke iko enweghị agba ya na olu dị milimita 2, 10 ampoules, ọnya ọkụ 5 na igbe kaadi.

Ihe ngosi maka ojiji

Ekwesiri iji Dicinon mee ihe maka ọgwụgwọ na mgbochi nke ọbara ọgbụgba dị okirikiri.

Dabere na ntuziaka, etamzilat dị irè na:

• Ọbara ọgbụgba na-ewere ọnọdụ n’oge yana mgbe a gwọchara ya n’ọkpụkpụ ahụ nke ọma (ọrịa arịa ọbara ruru n’arụ) n’ịkwarụ ukwu na ọrịa ụmụ nwanyị, omume ENT, ezé, ịwa ahụ plastik, urology, ophthalmology,
• Menorrhagia, gụnyere isi, yana ụmụ nwanyị nwere ọgwụ mgbochi intrauterine,
• Ọkụ ọgbụgba
• Hematuria,
• Nosebleeds
• Metrorrhagia,
• Ọrịa microfeiopathy na-arịa ọrịa shuga, gụnyere hemophthalmus, ọrịa retinopathy na-arịa ọbara ọbara, wdg,
• Ọrịa ịba ọchae nke ọbara n'ụba n'ime ụmụ amụrụ ọhụrụ, gụnyere ụmụ amụrụ n'afọ.

Ihe ngbanwe

Dabere na ntuziaka maka Dicinon, a na-egbochi iji ọgwụ ahụ eme ihe ma ọ bụrụ na onye ọrịa nwere:

• Ọrịa Neoplastic (tumor) nke akwara lymphatic na hematopoietic, gụnyere osteosarcoma, myeloblastic na lymphoblastic leukemia,
• Ọbara
• Nnukwu porphyria,
• Thromboembolism,
• Akpachapụ anya na njikọ nke mbadamba / ngwọta.

Ejiri Dicinon jiri nlezianya na-agwọ ndị ọrịa nwere ọrịa thrombosis ma ọ bụ thromboembolism, yana n'ọnọdụ ebe kpatara ọbara ọgbụgba bụ ọgwụ dị elu nke anticoagulants.

Usoro onunu ogwu na nhazi

Ezigbo ọgwụ Dicinon kwa ụbọchị na ụdị mbadamba sitere na 10 ruo 20 mg kwa kilogram 1 nke ịdị ahụ ya. Kewaa ya n'ime 3 ma ọ bụ 4 doses.

Dịka iwu, nkezi otu dose bụ 250-500 mg, n'ọnọdụ dị iche, ọ mụbara na 750 mg. Ugboro iji Dicinon bụ otu ihe, ugboro 3-4 kwa ụbọchị.

Na menorrhagia, ọgwụ etamzilate kwa ụbọchị sitere na 750 mg ruo 1 g Dicinon na-amalite ịbido site na ụbọchị nke ise nke oge ịtụ anya na ruo ụbọchị 5th nke usoro ọzọ.

Mgbe usoro ọgwụgwọ gasị, a na-atụ aro ka a drugụọ ọgwụ ahụ kwa awa 6 na 250-500 mg. Ere ọgwụ na-aga n’ihu ruo mgbe ihe ọ bụla dị n’iru ọbara.

Maka nwatakiri, otu udiri aka bu mgmill iri na isii n’ime otu kilogram n’arọ. Otutu nke ngwa - ugboro 3-4 kwa ụbọchị.

Ntụziaka maka Dicinon na-egosi na ịchọrọ ntụtụ ahụ ka agba agba ngwa ngwa. N'ọnọdụ ebe ejiri saline mee ọgwụ ahụ, ọgwụ ntụtụ kwesịrị ịme ozugbo.

Maka okenye, ọgwụ kwa ụbọchị bụ 10-20 mg / kg / ụbọchị, ekwesịrị ịkesa ya na 3-4.

Maka ebumnuche prophylactic n'oge usoro ịwa ahụ, a na-edozi Dicinon iv ma ọ bụ IM na ọnụọgụ 250-500 mg ihe dị ka otu awa tupu ịwa ahụ. N’oge ịwa ahụ, a na-enye ọgwụ ahụ n’ime ọgwụ mgbe ọ bụla, ọ bụrụ na ọ dị mkpa, iwebata ọgwụ a ugboro ugboro. N'ime oge ọmụmụ ahụ, a na-atụ aro iji Dicinon na usoro ọgwụgwọ oge ọ bụla n'ime elekere isii ruo mgbe ọnya ọbara ga-apụ n'anya.

Maka umuaka, a na-enyezi ihe a ga-eme iji dozie ya azịza nke 10-15 mg / kg / ụbọchị, kewara 3-4 injections. Na omume neonatolology, a na-abanye Dicinon na akwara ma ọ bụ nwayọ nwayọ n'ime akwara mgbe ọ dị 12.5 mg / kg (usoro ethamylate ahụ akọwapụtara dabara na 0.1 ml nke ihe ngwọta). Ọgwụgwọ bidoro n’awa abụọ mbụ nke ndụ nwata.

Ntụziaka pụrụ iche

A na-ezube usoro ogwu dicinon naanị maka iji rụọ n'ụlọ ọgwụ na ụlọ ọgwụ.

A machibidoro ịgwakọta ihe ngwọta dị na sirinji ya na ọgwụ ọ bụla. A machibidoro ya iji ihe ngwọta ma ọ bụrụ na agbanweela agba.

Okwesiri iburu n’uche na Dicinon na onwa nke 10 mg / kg, nke enyere otu awa tupu dextrans, na-egbochi uto antiplatelet ha. Na Dicinon, nke ewepụtara ka dextrans gasịrị, enweghị mmetụta hemostatic.

Dicinone adabaghị na sodium lactate na sodium bicarbonate na-eme ka ogwu sie ike. Ọ bụrụ na ọ dị mkpa, enwere ike ijikọ ya na sodium menadione bisulfite na aminocaproic acid.

Otu mbadamba Dicinon nwere 60.5 mg nke lactose (nke kachasị na-anabata ihe a bụ gram 5). Mbadamba ụrọ bụ ndị ọrịa nwere ụkọ lactase, enweghị nkwekọrịta glucose afọ, malabsorption nke glucose na galactose.

Agbanyeghị na eburu Dicinon maka nchịkwa intravening na intraven, enwere ike itinye ya n’uche, dịka ọmụmaatụ, mgbe mmesịrị ezé ma ọ bụ n’ihu ọnya ọzọ. Maka nke a, mpempe gauze ma ọ bụ akwa na-enweghị atụ na-enwe ihe dị ukwuu na ihe ga-etinye ya na mmerụ ahụ.

Usoro na ọnọdụ nchekwa

Dicinon bụ otu nke ọgwụ ọgwụ ndị ọgwụ rerere.

Dịka ntuziaka ahụ si dị, ekwesịrị ịchekwa ọgwụ ahụ ebe a na-echebe ya site na ìhè na mmiri (maka mbadamba), na-agaghị eru ụmụaka, ebe a na-edobe okpomọkụ ọ bụla karịa 25 ºС. Ndụ nchekwa nke ampoules na mbadamba nkume bụ afọ 5.

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Omume ọgwụ

Ihe na-arụ ọrụ nke Dicinon bụ ethamylate.

Ọgwụ nwere mmetụta hemostatic (ọ na-akwụsị ma ọ bụ belata ọbara ọgbụgba), nke a bụ n'ihi ike nke ọgwụ iji mee ka e guzobere thromboplastin mgbe obere arịa mebiri (guzobere na mbido mbụ nke usoro coagulation).

Ojiji nke Dicinon nwere ike ime ka nguzobe mucopolysaccharides (chebe eriri protein site na mmerụ ahụ) nke nnukwu oke na mgbidi nke capillaries, kwalite ikike nke capillaries, mee ka nkwụsi ike ha dịkwuo mma, melite microcirculation.

Dicinon enweghị ike ịba ụba coagulability ọbara ma mee ka vasoconstriction, na-esokwa mee ka e kee mkpụkọ ọbara. Dicinon na-amalite ime 1-2 awa mgbe nchịkwa ọnụ na 5-15 nkeji mgbe ọ gbasịrị. A na-ahụta ọgwụgwọ dicinone n'ime awa 4-6.

Mlọ ọgwụ

Mgbe etinyere ya, etamsylate na-agbadata ngwa ngwa site na eriri afọ. Mgbe nchịkwa ọnụ nke 50 mg nke ethamsylate, ọkwa plasma kachasị (ihe dị ka 15 μg / ml) ruru awa anọ. Ihu ọkara nke plasma bụ awa 3.7. Ihe dị ka 72% nke ọgwụ a na-etinye na-apụta na mmamịrị n'ime awa 24 mbụ.

Ethamsylate na-agafe ihe mgbochi placental ma banye n’ime mmiri ara.

Ime na lactation

Amaghi utị etamzilate n'ahụ ụmụ nwanyị dị ime. Ethamsylate na-agafe ihe mgbochi site na placental, yabụ a machibidoro iji ya n'oge ọnwa atọ mbụ. Ojiji adakarị n’oge ime adịchaghị maka ihe ndị a.

Ethamsylate banye n’ime mmiri ara. Ighaghi inye ara ara mgbe ị na-a thisụ ọgwụ a.

Usoro onunu ogwu na nhazi

Jiri na ndị okenye na ụmụaka karịrị afọ 14

Tupu ịwa ahụ: otu mbadamba abụọ nke Dicinon 250 mg (250-500 mg) maka otu awa tupu ịwa ahụ.

Mgbe a wasịrị ya ahụ: otu n’ime mbadamba nkume abụọ nke Dicinon 250 mg (250-500 mg) kwa awa 4-6, ebe enwere ọghọm ọbara.

Ọrịa dị n'ime: nkwuputa izugbe ka ị were mbadamba abụọ nke 250 mg abụọ Dicinon ugboro atọ n'ụbọchị (1000-1500 mg) na nri nwere obere mmiri. Gynecology, maka meno- / metroragia: were mbadamba abụọ nke Dicinon 250 mg ugboro atọ n'ụbọchị (1.500 mg) mgbe ị na-eri obere mmiri. Ọgwụ ahụ dị ụbọchị iri, bido ụbọchị ise tupu mmalite ọbara ọgbụgba ahụ amalite.

N’ụgwọ ọrịa ụmụaka (ụmụaka karịrị afọ isii)

Dosebọchị kwa ụbọchị bụ 10-15 mg / n'arọ nke ịdị arọ ahụ kwa ụbọchị, kewara n'ime usoro 3-4. Ogologo oge eji ọgwụ a na-adabere n'ọbara nke ọbara ọgbụgba na oke site na ụbọchị 3 ruo 14 site na oge ịkwụsị ọbara ọgbụgba na ụdị ndị ọrịa niile.

Mbadamba kwesịrị iwere n’oge nri ma ọ bụ n’oge nri

Onweghi ihe omumu n’ime ndi ọrịa nwere oruru akwara ma ọ bụ akụrụ. Ya mere, odi nkpa iji Dicinon jiri nlezianya na ndị ọrịa a

Ejila okpukpu abụọ iji kwụọ ụgwọ ihe ndị furu efu.

Mmetụta akụkụ

Mmetụta enwere ike ịchọrọ: isi ọwụwa, nkụda mmụọ, ihu ihu, nsogbu anụ ahụ na-adịte aka, ọgbụgbọ, mgbu epigastric, ụkwụ paresthesia. Mmeghachi omume ndị a dị obere, dịkwa nwayọọ.

Enwere ihe akaebe na n’ime ụmụaka nwere nnukwu lymphoid na ọrịa myelogenous leukemia, osteosarcoma, etamsylate, nke enyere maka igbochi ọbara ọgbụgba, kpatara nnukwu leukopenia. Dabere na ọtụtụ data ebipụtara, ojiji nke etamzilate n'ime ụmụaka amachibidoro.

Enwere ihe akaebe na ụmụ nwanyị ndị tinyere ethamsilate tupu ịwa ahụ nwere thrombosis mgbe hawachara ahụ na cervix. Agbanyeghị, ule ndị na-adịbeghị anya egosighi data ndị a.

Njirimara ngwa

Ekwesịrị iji ọgwụ kpachara anya ma ọ bụrụ na enwere akụkọ banyere thrombosis ma ọ bụ thromboembolism na ndị ọrịa, ma ọ bụ ọgwụ mgbochi. Dicinon nwere sọlfọ sulfur, nke mere na a ga-akpachara anya mgbe a na-elekọta ya ndị ọrịa asịrị na allergies. Tupu ịmalite ọgwụgwọ, a ga-eburu n'uche na ọgwụ ahụ adịghị arụ ọrụ na ndị ọrịa nwere thrombocytopenia.

N'ihi eziokwu ahụ bụ na ụmụaka ndị ekenyela Dicinon maka igbochi ọbara ọgbụgba na lymphoblastic na myeloid leukemia na osteosarcoma, ọnọdụ ahụ kawanyere njọ, ụfọdụ ndị na - ede akwụkwọ na-atụle iji ọgwụ ahụ eme ihe n'ọnọdụ ndị a ka ọ bụrụ ihe mgbochi.

Ekwesịrị inye ndị ọrịa nwere ọrịa heredite dị ka ụkọ lactase ma ọ bụ malabsorption nke glucose-galactose.

Ethamsylate anaghị emetụta ikike iji ụgbọ ala na-arụ ọrụ na usoro.

Ọ bụrụ n ’ike anabataghị carbohydrates, gwa dọkịta gị tupu ị theụọ ọgwụ ahụ.

Pharmacodynamics na pharmacokinetics

Ọgwụ na-akpali usoro nke platelet si ụmị ọkpụkpụna-eme ka agụmakwụkwọ ha sie ike. Ọgwụ ahụ nwere ọgwụ mgbochi yana mmerụ egwu angioprotective. Ọgwụ na - enyere aka ịkwụsị ọbara ọgbụgba, na - eme ka nguzobe ya dịkwuo elu isi thrombusEthamylate na - akwalite ntụgharị azụ, anaghị emetụta ya oge prothrombinfibrinogen ịta. N'inye ọgwụ ugboro ugboro, thrombosis na-abawanye. Dicinon na-ebelata diapesesis nke akpụ, ihe ndị metụtara ọbara site na akwa akwara, belata nsụpụta mmiri, na-emetụta nke ọma microcirculation. Ọgwụ a anaghị emetụta usoro nkịtị na usoro nke hemostatic. Dicinon nwere ike iweghachi oge ọbara ọgbụgba gbanwere n'ọrịa dị iche iche.

A na-enwe mmetụta nke hemostatic mgbe minit 10-15 gasịrị. A na-eru ọkwa kachasị elu nke ihe na-arụ ọrụ n'ime otu awa mgbe nchịkwa gasịrị. Ọ dịkwaghị agbanwe agbanwe n’ụbọchị mbụ ọ nwere mmamịrị kpamkpam.

Ntụziaka maka iji Dicinon

Dicinone dị n'ụdị ihe ngwọta maka nsị intravenous na intramuscular yana n'ụdị mbadamba nkume ezubere maka nchịkwa ọnụ. Ngwa nke Dicinone nwekwara ike kwe omume site n'itinye swab a gbanyere na mmiri ga-adị ọnya ahụ. Otu ampoule na otu mbadamba ihe ọ bụla nwere 250 mg nke etamsylate.

N'ọtụtụ oge, a na-atụ aro mbadamba Dicinon ka ọ bụrụ otu 1-2 PC. n'otu oge, ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ gaa na 3 PC. Otu uzo azịza maka injection na-abụkarị ½ ma ọ bụ 1 ampoule, ma ọ bụrụ na ọ dị mkpa - 1 po ampoule.

Maka ebumnuche prophylactic tupu ịwa ahụ: 250-500 mg nke etamsylate site na ntinye akwara ma ọ bụ intramuscular 1 awa tupu ịwa ahụ ma ọ bụ mbadamba 2-3 nke Dicinon awa 3 tupu ịwa ahụ. Ọ bụrụ na ọ dị mkpa, iji ọgwụ mgbochi intrave nke 1-2 ampoules nke ọgwụ n’oge ịwa ahụ ga-ekwe omume.

Ọbara ọgbụgba na akwara na-egosi ị takingụ mbadamba abụọ nke Dicinon kwa ụbọchị maka ụbọchị 5-10, ma ọ bụrụ na ọ dị mkpa ịgbatị usoro ọgwụgwọ ahụ, belata ọgwụ nke ọgwụ ahụ.

Dicinon maka nsọ nwanyị ka akwadoro ka ị were mbadamba mkpụrụ osisi 3-4 kwa ụbọchị maka ụbọchị iri - bido ụbọchị ise tupu nsọ nsọ wee gwụ n ’ụbọchị nke 5 nke nsọ nsọ. Iji mee ka mmetụta dị mma, ekwesịrị iburu mbadamba Dicinon dịka atụmatụ ahụ na usoro abụọ na-esochi.

N'ime ụbọchị 5-14, a na-atụ aro ka ị were mbadamba 3-4 nke Dicinon maka ọrịa nke usoro ọbara, hemorrhagic diathesis na ọrịa angiopathies (mmebi nke arịa ọbara).

Tupu arụ ọrụ maka ebumnuche profilactic, a na-enye ụmụaka Dicinon ka ọ bụrụ 1-12 mg / kg kwa ụbọchị maka ụbọchị 3-5. N'oge ịwa ahụ, nchịkwa intraven nke 8-10 mg / kg ga-ekwe omume, na mgbe a wachara ya ahụ iji gbochie ọbara ọgbụgba - 8 mg / kg n'ụdị mbadamba Dicinon.

Ọbara nchịkwa n'ime ụmụ na-agwọkwa ya site na nchịkwa ọnụ nke 6-8 mg / n'arọ ugboro atọ n'ụbọchị maka ụbọchị 5-14.

Na microangiopathy na-arịa ọrịa mamịrị, a na-atụ aro ka Dicinon na-elekọta intramuscularly na dose nke mg mg, ugboro 2 kwa ụbọchị maka ọnwa 2-3.

Nsonaazụ

Dicinon, iji ya mee ka ya na dọkịta kwenye, nwere ike ibute nsonaazụ ndị na-adịghị mma dịka oke ume na epigastric (akụkụ elu nke ogwe), obi mgbawa, akwara ọbara na ihu, ọgbụgbọ, isi ọwụwa, ọnụọgụ ụkwụ, mbelata ọbara mgbali, mmeghachi omume nfụkasị.

Mmekorita

Ejikọkwala Dicinon na ọgwụ ndị ọzọ n'otu sirinji. Iji gbochie ihe mgbochi antiplatelet dextrans A na-achịkwa dicinone otu awa tupu ha ejiri ya na 10 mg / kg. Ojiji nke etamzilate mgbe oge a anaghị enye mmetụta hemostatic. Enwere ike ijikọ ọgwụ ahụ na menadione sodium bisulfite, aminocaproic acid.

Mpempe usoro onunu ogwu

Mbadamba 250 mg

Otu mbadamba ihe nwere:

ike - etamsylate 250 mg

ndị na-ebu ụzọ: citric acid, ahịhịa ọka, lactose monohydrate, povidone, magnesium stearate.

Mbadamba ụrọ dị gburugburu, na-enwe biconvex elu, site na ọcha ruo ihe fọrọ nke nta ka ọ bụrụ ọcha.

Ngwongwo ogwu

Mlọ ọgwụEgwu Mgbe nchịkwa ọnụ gasịrị, a na-eji nwayọ nwayọ enweta ọgwụ site na eriri afọ. Mgbe ị theụsịrị ọgwụ ahụ na ọgwụ nke 500 mg, ịtinye uche kachasị na plasma ọbara na-erute mgbe awa anọ gasịrị ma ọ bụ 15 μg / ml.

Ogo nke jikọtara na protein plasma bụ ihe dịka 95%. Ethamsylate na-agafe ihe mgbochi placental. Ọbara nne nwa na eriri nwa nwere ụdị nke etamsylate. Enweghi data na ntinye ethamsylate na mmiri ara.

Ojiji Etamsylate ewepu site na akụrụ ya anaghị agbanwe agbanwe. Ọkara ndụ site na plasma ọbara dị ihe dị ka awa 8. Ihe dị ka 70-80% nke ọgwụ a isụrụ na-apụtazi n'ime awa iri abụọ na anọ mbụ yana mmamịrị na-agbanweghi.

Pharmacokinetics na ndị ọrịa nwere ọria imeju na ọrụ akụrụ

Emebeghị ka ụlọ ọgwụ pharmacokinetic nke etamsylate nwee ọrịa imeju na akụrụ.

Mlọ ọgwụ Ethamsylate bụ ọgwụ hemostatic na angioprotective ọgwụ eji mee ihe dị ka onye nnọchi anya hemostatic (njikọta nke endothelium-platelets). Site na imeziwanye ihe nracha nke platelet na weghachite nguzosi ike, ogwu a na -ebelata nnukwu oge oge obara na mbelata obara nke obara.

Ethamsylate enweghị mmetụta vasoconstrictor, ọ naghị emetụta fibrinolysis, ọ naghị agbanwe ihe ndị metụtara plasma coagulation.

Jiri n’oge ime na n’oge a na-enye nwa ara

Enweghị data nyocha gbasara ọgwụ iji Dicinon n'ime ụmụ nwanyị dị ime. Ojiji Dicinon n'oge ime ga-ekwe omume naanị ma ọ bụrụ na ebumnuche ebumnuche ya na nne ya karịrị akarị n'ihe nwa ebu n’afọ.
Enweghi data na ntinye ethamsylate na mmiri ara.
Yabụ, mgbe ị na-eji ọgwụ n’oge a na-enye nwa ara, a ga-ekpebi ihe a ga-akwụsị ịkwụsị inye ya ara.

Dodoụbiga ya ókè

Ruo ugbu a, ọ nweghị okwu ịdoụbiga mmanya ókè akọwapụtara.
Ọ bụrụ na ị overụbiga ihe oke ókè, ọ dị mkpa ịmalite usoro ọgwụgwọ symptomatic.

Mmekọrịta na ọgwụ ndị ọzọ

Enweghị data ọ bụla banyere mmekọrịta nke etamsylate na ọgwụ ndị ọzọ.
Ikekwe ngwakọta na aminocaproic acid na sodium menadione bisulfite.