Ntuziaka Metfogamma 1000 maka ojiji, contraindications, mmetụta ndị ọzọ, nyocha

Aha mba:Metfogamma 1000

Ngwakọta na ụdị ntọhapụ

Mbadamba mbadamba, ndị nwere ihe mkpuchi na-acha ọcha na-acha odo odo, dị egwu, na-enweghị ihe ọ bụla. Otu mbadamba 1 nwere 1000 mg nke meformin hydrochloride. Ndị pụrụ iche: hypromellose (15000 CPS) - 35.2 mg, povidone (K25) - 53 mg, magnesium stearate - 5.8 mg.

Ihe mejupụtara Shell: hypromellose (5 CPS) - 11.5 mg, macrogol 6000 - 2.3 mg, titanium dioxide - 9.2 mg.

N'ime blisters 30 ma ọ bụ mbadamba 120. Ihe ngwugwu na igbe kaadi.

Linlọ ọgwụ na ọgwụ ọgwụ

Ogwu hypoglycemic ọgwụ

Ndị na-ere ọgwụ

Ọrịa hypoglycemic maka nchịkwa ọnụ nke ìgwè biguanide

Ngwa ọgwụ ọgwụ Metfogamma 1000

Ọgwụ hypoglycemic ọgwụ sitere na ìgwè biguanide. Ọ na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose na eriri afọ, na - eme ka ojiji nke glucose na - emeju kwa oge, na - emekwa ka ọ nwee ọgụgụ isi nke insulin. Ọ naghị emetụta nzuzo nke insulin site na-sel nke pancreas.

Lowers triglycerides, LDL.

Na-eme ka ahụ gị dị ike ma ọ bụ belata ya.

O nwere mmetụta nke fibrinolytic n'ihi mkpochapụ nke plasminogen activates inhibitor anụ ahụ.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na ngọngọ nri. Bioavailability mgbe ị nwesịrị ọkọlọtọ bụ 50-60%. C max ka a na-enweta nchịkwa ọnụ mgbe awa 2 gachara

Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọ na gland ndị nwere akpụ, akwara, imeju na akụrụ.

A na - agbanwe ya na mmamịrị. T 1/2 bụ awa 1.5-4.5.

Pharmacokinetics n'ihe gbasara ọrịa

Site na arụ ọrụ ezumike n’akuku nsogbu, ịnwe ọgwụ ọgwụ ga-ekwe omume.

Elldị nke abụọ nke ọrịa shuga mellitus (nke na-abụghị insulin) na-enweghị ebumnuche nke ketoacidosis (karịsịa na ndị ọrịa na-ebu oke ibu) na usoro ọgwụgwọ nri anaghị arụ ọrụ.

Ihe ngbanwe

Hypersensitivity, hyperglycemic coma, ketoacidosis, ọdịda akụrụ na-adịghị ala ala, ọrịa imeju, ọrịa obi, ọrịa myocardial infarction, akụkụ okuku ume, akpịrị ịkpọ nkụ, ọrịa na-efe efe, nnukwu ọrụ na mmerụ ahụ, ị ​​alcoụ mmanya, nri obere kalori (ihe na-erughị 1000 kcal / ụbọchị), lactic acidosis (gụnyere akụkọ ntolite), afọ ime, lactation. Edeghị ọgwụ ahụ ụbọchị abụọ tupu ịwa ahụ, radioisotope, nyocha x-ray na ntinye nke ọdịiche ọgwụ yana n'ime ụbọchị 2 mgbe emechara ya. Ihe karịrị afọ 60, na-arụ ọrụ anụ ahụ dị arọ (ịba ụba nke ịmalite ịmalite lactic acidosis n'ime ha).

Usoro usoro onunu ogwu na usoro nke ngwa Metfogamma 1000

Tọọ iche, ichebara ọkwa glucose dị n’ọbara.

Usoro izizi na-abụkarị 500 mg-1000 mg (1 / 2-1 tab.) / Day. Mmụba nke iji nwayọọ nwayọọ na-abawanye na ọgwụ ọ ga-ekwe omume dabere na nsonaazụ ọgwụgwọ.

Igo ndozi bu 1-2 g (1-2 mbadamba) / ubochi. Oke kachasị kwa ụbọchị bụ 3 g (mbadamba 3). Ebumnuche nke ọgwụ na usoro ọgwụgwọ dị elu adịghị abawanye nsonaazụ nke usoro ọgwụgwọ ahụ.

E kwesịrị iri mbadamba dị ka ihe dị mkpa, were obere mmiri hichaa ya (iko mmiri).

A na-ezube ọgwụ a maka iji ogologo oge.

N'ihi ịba ụba nke lactic acidosis, n'ọrịa metabolic siri ike, a ga-ebelata dose ahụ.

Nsonaazụ

Site na nri digestive: ọgbụgbọ, ọgbụgbọ, mgbu afọ, afọ ọsịsa, enweghị agụụ, ụtọ ọla na ọnụ (dịka iwu, anaghị achọ ọgwụgwọ, na ihe mgbaàmà na-apụ n'anya na-enweghị ịgbanwe ọgwụ, ugboro ole na mmetụta nke mmetụta ọjọọ nwere ike belata ya na mmụba nwayọ na oke nke metformin), adịkarịghị - ọnya pathologies nke nyocha imeju, ịba ọcha n'anya (gafere mgbe mwepụ ọgwụ).

Mmeghachi omume nfụkasị ahụ: akpukpo aru.

Site na usoro endocrine: hypoglycemia (mgbe eji ya na-ekwesịghị ekwesị).

Site n'akụkụ nke metabolism: adịkarịghị - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ), na iji ogologo oge - hypovitaminosis B₁₂ (malabsorption).

Site na sistemụ hemopoietic: n'ihe ụfọdụ - megaloblastic anaemia.

Ime na lactation

A na - egbochi ọgwụ maka iji ya n'afọ na ịra ara (ara) .Mgbakwunye arịrịọ maka ọrụ imeju na - emeju ọgwụ. E mejupụtara ọgwụ ahụ maka arụ ọrụ ezughi oke.

Jiri ndị ọrịa agadi

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị ọrịa gaferela afọ 60 ndị na-arụ ọrụ anụ ahụ dị arọ, n'ihi oke ụba nke lactic acidosis.

Ntụziaka pụrụ iche maka nnabata Metfogamma 1000

N'oge ọgwụgwọ, ọ dị mkpa ileba anya maka ọrụ akụrụngwa; ekwesịrị ime mkpebi nke plasma lactate ọbụlagodi ugboro abụọ n’afọ, yana n’ile anya myalgia. Site na mmepe nke lactic acidosis, achọrọ ịkwụsị ọgwụgwọ. A naghị akwado oge itinye oge maka ọrịa dị egwu, mmerụ ahụ, na ihe ize ndụ nke akpịrị mmiri. Site na iji ọgwụgwọ na usoro ọgwụgwọ gluonylurea, nlezianya ịchebara ọkwa glucose ọbara dị mkpa. A na-atụ aro iji ọgwụ jikọtara insulin n'ụlọ ọgwụ.

Dodoụbiga ya ókè

Ọrịa egbu egbu lactic acidosis nwere ike ịmalite. Ihe kpatara mmepe nke lactic acidosis nwekwara ike ịbụ nchịkọta nke ọgwụ ahụ n'ihi ọrụ ezumike arụrụ yana ọrụ. Ihe mgbaàmà izizi nke lactic acidosis bụ ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, iwetulata ahụ, mgbu afọ, olu mgbu, n'ọdịniihu enwere ike iku ume ngwa ngwa, ọgbụgbọ, nsụda mmụọ na mmepe nke coma.

Ọgwụgwọ: ọ bụrụ na enwere ihe ịrịba ama nke lactic acidosis, a ga-akwụsị ọgwụgwọ na Metfogamma 1000 ozugbo, onye ọrịa ahụ kwesịrị ịga ụlọ ọgwụ ngwa ngwa, ebe o kpebisiri ike ịba uru nke lactate, gosipụta nchoputa ahụ. Usoro ọgwụgwọ kachasị dị mma maka iwepụ lactate na metformin n'ahụ ahụ. Ọ bụrụ na ọ dị mkpa, mee ọgwụgwọ Symptomatic.

Site na njikọta ọgwụgwọ na sulfonylureas, hypoglycemia nwere ike ịmalite.

Mmekọrịta na ọgwụ ndị ọzọ

N'iji oge a nifedipine eme ka mmata nke metformin, C_maxna-eji nwayọ nwayọ kwụsịlata.

Ọgwụ cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) zoro ezo na tubules na-asọrịta mpi maka sistemụ tubular na, site na ọgwụgwọ ogologo oge, nwere ike ịbawanye C_max 60% metformin.

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, NSAIDs, MAO inhibitors, oxygentetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide na beta-blockers, ọ ga-ekwe omume ịbawanye hypoglycemic mmetụta nke metformin.

Site na iji GCS eme ihe n'otu oge, mgbochi ogwu a na-aralụ aineụ, epinephrine (adrenaline), sympathomimetics, glucagon, homonụ thyroid, thiazide na loopback diure, ntụpọ phenothiazine na nicotinic acid, mbelata mmetụta hypoglycemic nke metformin kwere omume.

Cimetidine belatara mkpochapu nke metformin, n'ihi ihe nke lactic acidosis na-abawanye.

Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin).

Site na nchịkwa oge nke ethanol, mmepe nke lactic acidosis ga-ekwe omume.

Usoro ahịa ọgwụ ahịa

Ogwu gi bu ogwu.

Usoro na ọnọdụ nchekwa Metfogamma 1000

Ekwesịrị ịchekwa ọgwụ ahụ ka ụmụaka ghara iru ya na okpomọkụ agaghị agafe 25 Celsius. Ndụ shelf bụ afọ 4.

Ejiri Metfogamma 1000 nke ọgwụ ahụ naanị dịka dọkịta nyere ya, a na-enye nkọwa ahụ maka ntụnye!

Mwepụta ewepụtara Metfogamma 1000, nkwakọ ngwaahịa ọgwụ na ihe mejupụtara.

Mbadamba ụrọ a kpuchiri ekpuchi
Taabụ 1
metformin hydrochloride
1 g

Ndị ọbịa: hypromellose (15,000 CPS), magnesium stearate, povidone (K25).

Ihe mejupụtara Shell: hypromellose (5CPS), macrogol 6000, titanium dioxide.

10 PC. - blisters (3) - ngwugwu nke kaadiboodu.
10 PC. - blisters (12) - ngwugwu nke kaadiboodu.
15 PC. - blisters (2) - ngwugwu nke kaadiboodu.
15 PC. - blisters (8) - ngwugwu nke kaadiboodu.

NWAANYI NIILE ANYA.
A na-egosi ozi niile enyere naanị maka ịmara ọgwụ ahụ, ị ​​kwesịrị ịkpọtụrụ dọkịta maka ohere eji ya.

Ngwa Pharmacological Metfogamma 1000

Onye na-ahụ maka hypoglycemic nke sitere na ìgwè nke biguanides (dimethylbiguanide). Usoro nke metformin na-ejikọta ya na ikike ya iji mee ka gluconeogenesis kwụsị, yana imepụta abụba na-enweghị ihe na nsị nke abụba. Metformin anaghị emetụta oke insulin n'ime ọbara, mana ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe ma na-abawanye oke nke insulin na proinsulin. Otu njikọ dị mkpa na usoro nke metformin bụ mkpali nke glucose na - eme ka mkpụrụ ndụ mepụta ya.

Metformin na - akwalite mgbasa ọbara n'ime imeju na-emekwa ka ntụgharị glucose na glycogen gbanwee. Belata ogo triglycerides, LDL, VLDL. Metformin na - eme ka akwara fibrinolytic dị n'ọbara site na - egbochi ihe mgbochi plasminogen onye na - eme ka anụ ahụ nwee ọrụ.

Pharmacokinetics nke ọgwụ.

A na-etinye Metformin na ngọngọ diges. Cmax na plasma erutela ihe dị ka awa 2 mgbe ịbasịsịrị. Ka awa 6 gachara, iwere si eriri afọ ga-akwụsị ma tinyekwa metformin na plasma nke nta nke nta.

Ọ fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ na-agbakọta na gland salvary, imeju na akụrụ.

Oge T1 / 2 - awa nke awa nke 1,5-4.5. Ọ bụ akụrụ na-ewepụ ya.

Ọ bụrụ na arụ ọrụ ezumike ezumike, nnuku metformin ga-ekwe omume.

Usoro onunu ogwu na uzo icho ogwu a.

Maka ndị ọrịa anaghị anata insulin, n’ime ụbọchị atọ ndị mbụ - 500 mg ugboro atọ / ụbọchị ma ọ bụ 1 g ugboro abụọ / ụbọchị n’oge ma ọ bụ mgbe nri gasịrị. Site n'ụbọchị nke anọ ruo ụbọchị nke 14 - 1 g ugboro atọ / ụbọchị. Mgbe ụbọchị nke iri na ise gasịrị, a na-agbazi dose a na-eburu n'uche ogo glucose dị n'ọbara na mmamịrị. Usoro nlekọta ahụ bụ 100-200 mg / ụbọchị.

N'iji insulin emeghari onodu ya na oge erughi 40 nkeji / ubochi, usoro onunu ogwu nke metformin bu otu, ebe enwere ike wedata uzo insulin jiri nwayọ belata (site na nkeji 4-8 / ubochi ubochi obula). Ọ bụrụ na onye ọrịa ahụ na-enweta ihe karịrị nkeji iri anọ / ụbọchị, mgbe ahụ, ojiji nke metformin na mbelata nke insulin chọrọ nlekọta dị ukwuu ma eme ya n'ụlọ ọgwụ.

Mmetụta akụkụ Metphogamma 1000:

Site na usoro nri: enwere ike (ọ na-abụkarị mmalite nke ọgwụgwọ) ọgbụgbọ, ọgbụgbọ, afọ ọsịsa.

Site na usoro endocrine: hypoglycemia (tumadi mgbe ejiri ya na usoro ezughị ezu).

Site n'akụkụ nke metabolism: n'ọnọdụ ụfọdụ - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Site na usoro hemopoietic: n'ọnọdụ ụfọdụ - megaloblastic anaemia.

Ihe mgbochi ọgwụ:

Mmebi siri ike nke imeju na akụrụ, obi na akụkụ iku ume, oke akụkụ nke myocardial infarction, ahoụrụma na-egbu egbu, ọrịa shuga, ketoacidosis, lactic acidosis (gụnyere akụkọ ntolite), ọrịa mamịrị ụkwụ na-arịa ọrịa shuga, ịtụrụ ime, lactation, hyperensitivity to metformin.

NKWREKWỌ na mmechi
Contraindicated na ime na lactation.

Ntụziaka pụrụ iche maka iji Metfogamma 1000.

A naghị akwado ya maka ọrịa na-efe efe, iwe ọkụ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala, na ihe ize ndụ nke akpịrị ịkpọ nkụ.

Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha.

A naghị atụ aro iji metformin na ndị ọrịa gafere afọ 60 na ndị na-arụ ọrụ anụ ahụ dị arọ, nke jikọtara ya na oke ihe ize ndụ nke ịmalite lactic acidosis.

N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ gbasara akụrụ, mkpebi nke lactate dị na plasma kwesịrị ịdịkarịa ala ugboro abụọ n’afọ, yana mpụta nke myalgia.

Enwere ike iji Metformin mee ihe na njikọta na sulfonylureas. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

A na-atụ aro iji metformin dịka akụkụ nke njikọta ọgwụ na insulin n'ụlọ ọgwụ.

Nmekorita nke Metfogamma 1000 yana ogwu ndi ozo.

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, yana clofibrate, cyclophosphamide, hypoglycemic mmetụta nke metformin nwere ike ịkwalite.

Site na iji GCS eme ihe n'otu oge, mgbochi nke homonụ maka nchịkwa ọnụ, adrenaline, glucagon, homonụ thyroid, ihe ndị phenothiazine, thiazide diuretics, nicotinic acid, na mbelata mmetụta hypoglycemic nke metformin ga-ekwe omume.

Iji cimetidine na-ejikọ ọnụ nwere ike ịbawanye ohere nke lactic acidosis.

Ihe onyonyo 3D

Mlọ ọgwụ

Ọ na - egbochi gluconeogenesis na imeju, na - ebelata nnabata nke glucose site na eriri afọ, na - eme ka ojiji nke glucose na - emeju kwa oge, na - emekwa ka ọ nwee mmetụta nke anụ ahụ na insulin. Na-ebelata ọkwa nke triglycerides na obere lipoproteins dị ala n'ime ọbara. Ọ nwere mmetụta nke fibrinolytic (na-egbochi ọrụ nke plasminogen activator inhibitor anụ ahụ), na-eme ka ahụ sie ike ma ọ bụ belata ibu ahụ.

Nsonaazụ

Site na sisitemu obi na obara (hematopoiesis, hemostasis): n'ọnọdụ ụfọdụ megaloblastic anaemia.

Site na ngwara: ọgbụgbọ, ọgbụgbọ, mgbu afọ, afọ ọsịsa, enweghị agụụ, ụtọ dị n'ọnụ.

Site n'akụkụ nke metabolism: hypoglycemia, n'ọnọdụ ndị na-adịghị ahụkebe, lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Mmeghachi omume nfụkasị ahụ: akpukpo aru.

Ugboro na ogo mmetụta ya na-esite na mgbari nri nwere ike wedata jiri mmụba nwayọ nwayọ na usoro metformin. N'ọnọdụ ndị na-adịghị ahụkebe, ọnya ọrịa na - adọ adọ nke ihe nlere nke imeju ma ọ bụ ịba ọcha n'anya na-apụ mgbe ịhapụ ọgwụ gachara.

Site n'akụkụ nke metabolism: ya na ọgwụgwọ ogologo - hypovitaminosis B₁₂ (malabsorption.)

Usoro onunu ogwu na nhazi

N'ime mgbe ị na-eri nri, na-a plentyụ ọtụtụ mmiri mmiri (otu iko mmiri). A na-etinye dose ahụ n’otu n’otu, na-eburu n’uche nke glucose n’ime ọbara.

Usoro izizi na-abụkarị 500-1000 mg (1/2/1 mbadamba) kwa ụbọchị, mmụba na-arịwanye elu nke dose ga-ekwe omume dabere na nsonaazụ ọgwụgwọ.

Nlekọta kwa ụbọchị bụ 1-2 g (1-2 mbadamba) kwa ụbọchị, nke kachasị - 3 g (3 mbadamba) kwa ụbọchị. Nhọpụta nke usoro ọgwụgwọ dị elu adịghị abawanye mmetụta nke ọgwụgwọ ahụ.

N'ime ndị ọrịa agadi, ọgwụ kwa ụbọchị ekwesịghị ịgabiga 1000 mg / ụbọchị.

Ọgwụgwọ ọ dị ogologo.

N'ihi oke ịba ụba nke lactic acidosis, a ga-ebelata oke ọgwụ ahụ na nsogbu metabolic siri ike.

Ntụziaka pụrụ iche

A naghị akwado ya maka ọrịa na-efe efe ma ọ bụ njọ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala ala, tupu ịwa ahụ na n'ime ụbọchị 2 mgbe a gbasịrị ha, yana n'ime ụbọchị 2 tupu yana mgbe nyocha nyocha (ọgwụ na redio). iji ọdịiche nke mgbasa ozi). Ekwesighi iji ya na ndị ọrịa na nri nwere mmachi na oriri caloric (erughị 1000 kcal / ụbọchị).A naghị atụ aro iji ọgwụ a eme ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ nnukwu ọrụ anụ ahụ (n'ihi oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis).

Ọ ga - ekwe omume iji ọgwụ a jikọtara ya na ihe ndị na - eme ka sulfonylurea ma ọ bụ insulin. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ. Enweghị mmetụta (mgbe eji ya monotherapy). Na mgbakwunye na ndị nnọchi hypoglycemic ndị ọzọ (usoro sulfonylurea, insulin, wdg), mmepe nke steeti hypoglycemic ga-ekwe omume, nke ike ịnya ụgbọ ala na itinye aka na ihe omume ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor.

Emeputa

Ihe njide akwụkwọ ndebanye aha: Verwag Pharma GmbH & Co. KG, Kalverstrasse 7, 71034, Beblingen, Germany.

Onye nrụpụta: Dragenopharm Apotheker Püschl GmbH & Co. KG, Germany.

Lọ ọrụ nnọchite anya / ụlọ ọrụ na-anabata nnabata: ụlọ ọrụ nnọchite anya ụlọ ọrụ Vervag Pharma GmbH & Co. CG na Russian Federation.

117587, Moscow, Warsaw awara awara, 125 F, bldg. 6.

Tẹ.: (495) 382-85-56.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, mgbe nri ma ọ bụ ozugbo nri gasịrị, maka ndị ọrịa anaghị enweta insulin - 1 g (mbadamba abụọ) ugboro 2 n'ụbọchị n'ụbọchị 3 mbụ ma ọ bụ 500 mg ugboro atọ kwa ụbọchị, mgbe ahụ site na ụbọchị anọ ruo ụbọchị iri na anọ - 1 g ugboro atọ n’ụbọchị, mgbe ụbọchị iri na ise gachara, a ga-belata usoro ihe omimi n’iburu n’obi glucose dị n’ọbara na mmamịrị. Mmezi kwa ụbọchị - 1-2 g.

A na-ewere mbadamba azụ (850 mg) 1 n'ụtụtụ na mgbede. Oke kachasị kwa ụbọchị bụ 3 g.

N'iji insulin emeghari onodu ya na oge erughi 40 nkeji / ubochi, usoro onunu ogwu nke metformin bu otu, ebe enwere ike wedata uzo insulin jiri nwayọ belata (site na nkeji 4-8 / ubochi ubochi obula). Mgbe dose insulin karịrị 40 nkeji / ụbọchị, ojiji nke metformin na mbelata nke insulin chọrọ nlekọta dị ukwuu ma eme ya n'ụlọ ọgwụ.

Ajuju, azịza, nyocha banyere ọgwụ Metfogamma 1000

Ihe omuma a enyere ndi okacha amara n’ulo ogwu. Ihe omuma nke oma banyere ogwu a di na ntuziaka ndi emeputara na nkwakọ. Enweghị ozi edeputara na ibe a ma ọ bụ na saịtị ọ bụla ọzọ nwere ike ịnọchite anya arịrịọ nke onye ọkachamara.

Mmekọrịta na ọgwụ ndị ọzọ

Nifedipine na-abawanye mmịpụta, C_tahna-eji nwayọ nwayọ kwụsịlata. Ọgwụ cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ụgbọ njem tubular na, site na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye C_tah site na 60%.

Mgbe ejiri otu ihe eji eme ihe na - eme ka anakpo insulinalrea, acarbose, insulin, ọgwụ na - abụghị steroidal anti-inflammatory ọgwụ, monoamine oxidase inhibitors, oxygentetracycline inhibitors, angiotensin-na-agbanwe ntụgharị enzyme, • ngwa ngwa lofibrate, cyclophosphamide, glucose-ngwa-ngwa-ngwa-ngwa-ngwa-ala, , epinephrine, sympathomimetics, glucagon, homonụ thyroid, thiazide na anụ ụlọ evymi "diuretics, phenothiazine nkwekọrịta, nicotinic acid pụrụ ibelata hypoglycemic edinam nke metformin.

Cimetidine belatara mkpochapu nke metformin, nke na-abawanye ohere nke lactic acidosis. Metformin nwere ike ịkụda nsonaazụ anticoagulants (ọgwụ coumarin). N'ihi ị alcoholụ mmanya n'otu oge, lactic acidosis nwere ike ịmalite.

Njirimara ngwa

N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ akụrụngwa. Ọbụlagodi ugboro 2 n’afọ, yana ọdịdị myalgia, mkpebi nke plasma lactate kwesịrị ime. Ọ ga-ekwe omume iji Metfogamma® 1000 na nchịkọta ma ọ bụ insulin. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ Mgbe ị na-eji ọgwụ ahụ na monotherapy, ọ naghị emetụta ikike ịkwọ ụgbọala na usoro. Mgbe ejikọtara metformin na ndị ọzọ hypoglycemic (ihe dị n'ụkpụrụ sulfonylurea, insulin, wdg), ọnọdụ hypoglycemic nwere ike ịmalite nke ike ịkwọ ụgbọala na itinye aka na ọrụ ndị ọzọ dị ize ndụ nke chọrọ nlebara anya na mmeghachi omume psychomotor ngwa ngwa.