Ọgwụ Amikacin 500: ntuziaka maka ojiji

Mkpụrụ ọgwụ mgbochi ọrịa nke dị obere nke na-eme ka nje bacteria na-arụ ọrụ. Site na itinye 30S nke ribosomes nke 30S, ọ na-egbochi ịmepụta njem nke ụgbọ njem na onye ozi RNA, na-egbochi mkpokọ protein, ma na-ebibakwa membranes cytoplasmic nke nje.

Ọ na-arụ ọrụ nke ukwuu megide microorganisms aerobic gram-አሉታዊ Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp. ), ụfọdụ microorganisms gram-gram-Staphylococcus spp. (gụnyere ndị na-eguzogide ọgwụ na penisilini, ụfọdụ cephalosporins), na-agafe agafe agafe megide Streptococcus spp.

Site na nchịkwa nke oge a na benzylpenicillin, ọ nwere mmetụta synergistic dabere na njikọ nke Enterococcus faecalis.

Ọ dịghị emetụta microorganisms anaerobic.

Amikacin anaghị efunahụ ọrụ n'okpuru ọrụ nke enzymes inactivating amino glycosides ndị ọzọ, ma nwee ike nọgidesie ike na nsogbu nke Pseudomonas aeruginosa na-eguzogide tobramycin, gentamicin na netilmicin.

Mlọ ọgwụ

Mgbe nchịkwa intramuscular (IM), ọ na-abanye ngwa ngwa na kpamkpam. Ntinye kachasị (Stax) na nchịkwa m / mịnịstrị 7.5 mg / n'arọ bụ 21 μg / ml. Oge ị ga - eji nweta oge ịta (TSmax) bụ ihe dị ka awa 1.5 mgbe nchịkwa m. Nkwurita okwu na protein protein - 4-11%.

A na-ekesa ya nke ọma na mmiri extracellular (ọdịnaya nke etuto, ihe na-akpali agụụ mmekọahụ, ascitic, pericardial, synovial, lymphatic na peritoneal

mmiri), na oke ọnụnọ dị na mmamịrị, dị ala - na bile, mmiri ara, nwa na-a theụrị ọ ,ụ nke anya, mmiri bronchial, sputum na mmiri akpa (CSF). Ọ na-abanye nke ọma na akwara niile nke anụ ahụ ebe ọ na-agbakọta intracellularly, a na-ahụ ihe ndị dị elu na akụkụ ahụ nwere ọbara dị mma: akpa ume, imeju, myocardium, na akụrụ na akụrụ, ebe ọ na-agbakọ na oyi akwa cortical, mkpụkọ dị ala - na akwara, adipose anụ ahụ na ọkpụkpụ.

Mgbe etinyere ndi okenye, amikacin edeputaghi usoro ogwu ogwu di ya, ya na oria nke meninges, permeability na-abawanye ntakịrị. N'ime ụmụ amụrụ ọhụrụ, a na-enwetara ohere dị elu na CSF karịa na ndị okenye, na-agafe na Plasenta - a hụrụ n'ọbara nke nwa ebu n'afọ na mmiri ọmụmụ. Olu nkesa na ndị okenye - 0.26 l / n'arọ, na ụmụaka - 0.2-0.4 l / n'arọ, na ụmụ amụrụ ọhụrụ - nke na-erughị izu 1 na ịdị arọ ya erughị 1.5 n'arọ - ruo 0.68 l / n'arọ erughị otu izu na ahụ ha karịrị 1.5 n'arọ - ihe ruru 0,58 l / n'arọ, n'ime ndị ọrịa nwere cystic fibrosis - 0.3-0.39 l / n'arọ. A na-ejigide oge ịta ọgwụgwọ na nchịkwa m ruo elekere 10-12.

Emeghị metabolized. Ọkara ndụ (T1 / 2) na ndị okenye bụ awa 2-4, na ụmụ amụrụ ọhụrụ -5-8 awa, na ụmụaka toro eto - awa nke 2.5-4. Uru ikpeazụ nke T1 / 2 karịrị 100 awa (ewepụtara site na depot intracellular) .

Ọ bụ ya mere akụrụ site na nzacha ụwa (65-94%), ọkachasị adịghị agbanwe agbanwe. Mkpochapu ntaramahụhụ - 79-100 ml / min.

T1 / 2 n'ime ndị okenye nwere ọrụ gbasara akụrụ nwere nsogbu dịgasị iche dabere na ogo nke enweghi ike - rue 100 awa, n'ime ndị ọrịa nwere cystic fibrosis -1-2 awa, n'ime ndị ọrịa nwere oke ọkụ na ọbara mgbali elu, T1 / 2 nwere ike ịdị mkpụmkpụ karịa nkezi n'ihi mmụba dị elu n'ihi mmụcha dị elu. .

A na-ewepụ ya n'oge ịba ọcha n'anya (50% na awa 4-6), usoro nyocha nke na - adịchaghị mma (25% na awa 48-72).

Ihe ngosi maka ojiji

Ezubere ya maka ọgwụgwọ nke ọrịa na-efe efe na ọnya ọrịa nke microorganisms nwere mmetụta amikacin: akụkụ iku ume (akwara umeji, oyi baa, pleural empirma, ọnya afọ), sepsis, ọrịa endocarditis, Central ụjọ system (gụnyere meningitis), na oghere afọ (gụnyere peritonitis) ọnya mkpụrụ ndụ (pyelonephritis, cystitis, urethritis), anụ ahụ na anụ ahụ dị nro (gụnyere ọnya na-efe efe, ọnya nje na ọnya dị iche iche), ọnya biliary, ọkpụkpụ na nkwonkwo (gụnyere osteomyelitis) ọnya ọnya ktsiya, ọrịa na-efe efe.

Ihe ngbanwe Hypersensitivity (gụnyere akụkọ ihe mere eme nke aminoglycosides ndị ọzọ), auditory irighiri akwara neuritis, oké ịba uru akụrụ na-adịghị ala ala (CRF) na azotemia na uremia, ịtụrụ ime, lactation ..

Na-akpachara anya. Myasthenia gravis, parkinsonism, botulism (aminoglycosides nwere ike ibute mgbasa nke neuromuscular, nke na-eduga n’ihu na-eme ka uru ahụ ndị ọzọ na-eme ka ọkpụkpụ ghara ịdị gara gara), nkụda mmụọ, ọdịda akụrụngwa, oge ịmụ nwa, oge ụmụaka tozuru oke.

Ime na lactation

. Iji amikacin eme ihe n’oge ime. Aminoglycosides nwere ike igbochi mmepe ẹmbrayo ma enyere nwanyị dị ime. Aminoglycosides na-agafe Plasenta; mmepe nke ntị chikasị nke ịmụ nwa na ụmụaka nke nne ya nwetara streptomycin n'oge afọ ime. Ọ bụ ezie na ọghọm ya dị njọ ma ọ bụ na nwa amụrụ ọhụrụ ahụghị mgbe enyere ụmụ nwanyị dị ime aminoglycosides ndị ọzọ, mmerụ ahụ dị. Nyocha omumu nke amikacin na oke na ụmụ oke egosiputaghị akara nke ọmụmụ ma ọ bụ mmerụ ahụ nke metụtara imikacin.

Amabeghị ma amikacin abanye n’a intoụ ara. N'oge a na-eji amikacin, a naghị akwado ara ara.

Usoro onunu ogwu na nhazi

Maka ọtụtụ ọrịa, a na-atụ aro nchịkwa intramuscular. N'ọnọdụ nje ọrịa na-eyi ndụ egwu ma ọ bụ ọ bụrụ na nchịkwa intramuscular agaghị ekwe omume, edere ha nwayọ nwayọ n'ime ụgbọelu (nkeji 2-3), ma ọ bụ infusion (0.25% ngwọta 30 nkeji).

Nlekọta intramuscular na intravenal

Enwere ike inye Amikacin intramuscularly na intravenously. Mgbe etinyere ya na usoro onunu ogwu echekwara maka oria na-adighi agha nke microorganism na-enwe ike, a ga-enweta azịza ọgwụgwọ n'ime awa 24-48.

Ọ bụrụ na enwetaghị azịza ọgwụgwọ ụlọ ọgwụ n'ime ụbọchị 3-5, ekwesịrị ịkọ usoro ọgwụgwọ ọzọ.

Tupu ịkọwa amikacin, ị ga-emerịrị:

• tụọ ọrụ gbasara akụrụ site na ịta nrapụta nke creatinine ma ọ bụ site na ịgbakọ larịị nke creatinine (ọ dị mkpa ka ị nyochaa ọrụ akụrụngwa n'oge eji amikacin),

Ọ bụrụ na ọ ga-ekwe omume, ị ga-ekpebi ịgara ọbara n'ime amikacin (kacha na kacha nta oge niile n'oge oge

Zere kachasi mkpo nke amikacin (nkeji 30-90 mgbe agwara) nke ihe karịrị 35 μg / ml, ntinye uche nke kacha nta (ozugbo tupu usoro nke ọzọ) nke ihe karịrị 10 μg / ml.

N'ime ndị ọrịa nwere ọrụ ezumike nkịtị, enwere ike ịkọ amikacin oge 1 kwa ụbọchị, na nke a, ịta kachasị serum nwere ike karịa 35 μg / ml. Ogologo oge ọgwụgwọ bụ 7-10 ụbọchị.

Nchịkọta ha dum, agbanyeghị ụzọ nchịkwa, ekwesịghị ịgafe 15-20 mg / kg / ụbọchị.

N’ime ọrịa ọgbaghara, ọ bụrụ na ọ dị mkpa ịgwọ ihe karịrị ụbọchị iri, ọ dị mkpa ka arụ ọrụ akụrụ, auditory na vestibular sensory system, yana usoro amamacin serum amikacin.

Ọ bụrụ na enweghị ọgwụgwọ n’ụlọ ọgwụ n’ime ụbọchị 3-5, a ga-akwụsị iji amikacin, ma kwesiri inyocha nyocha nke microorganisms ka amikacin.

Ndị okenye na ụmụaka karịrị afọ iri na abụọ - na arụ ọrụ akụrụ dịkarịsịrị (okike klọọkụ> 50 ml / min) i / m ma ọ bụ iv 15 mg / kg / ụbọchị 1 oge kwa ụbọchị ma ọ bụ 7.5 mg / kg kwa awa 12. Ngụkọta ụbọchị kwa ụbọchị ekwesịghị gafere 1.5 g. N'ihi na endocarditis na febrile neutropenia, a ga-ekewa kwa ụbọchị ka ọ bụrụ usoro abụọ, n'ihi na ezughi oke data na nnabata 1 oge kwa ụbọchị.

4mụaka izu anọ - afọ iri na abụọ - na arụmọrụ nkịtị na-arụ ọrụ (mwepụta creatinine> 50 ml / min) m / m ma ọ bụ m / v (jiri nwayọ na-agbakọta) 15-20 mg / kg / ụbọchị 1 oge kwa ụbọchị ma ọ bụ

7.5 mg / n'arọ kwa awa iri na abụọ. Na endocarditis na febrile neutropenia, a ga-ekewa ọgwụ kwa ụbọchị n'ime usoro abụọ, n'ihi ezughi oke data na nnabata 1 oge kwa ụbọchị. Newmụ amụrụ ọhụrụ - ọgwụ mbu bidoro 10 mg / kg, yabụ 7.5 mg / n'arọ kwa awa iri na abụọ.

Matmụ amụrụ ime - 7.5 mg / n'arọ kwa awa iri na abụọ.

Ndụmọdụ pụrụ iche maka nchịkwa ọgbụgba. Maka ndị okenye na ụmụaka, a na-enyekarị amikacin ngwọta n'ime oge 30-60.

Shouldmụaka na-erubeghị afọ abụọ kwesịrị inye ha ihe ruru awa 1 ruo 2.

Ekwesighi itinye ọgwụ Amikacin na ọgwụ ndị ọzọ, mana ekwesịrị ịnwe ya iche dabere na usoro nchịkwa a tụrụ aro ya.

Ndị okenye nwere ikike. AỌ bụ akụrụ emeela mycacin. Ekwesịrị inyocha ọrụ mmerụ ahụ yana usoro enyere n'iwu ka ahụọ yana ana arụ ọrụ ezumike.

Na-eyi ndụ egwu na / ma ọ bụ Pseudomonas kpatara. DEnwere ike ịbawanye oz oz to 500 mg kwa elekere asatọ ọ bụla, mana ekwesighi ịnye amikacin na dose karịa

1.5 g kwa ụbọchị, ma ọ dịghị ihe karịrị ụbọchị 10. Mkpokọta ogo ịchọrọ agaghị agafe gram 15.

Insectsmụ ahụhụ ọnya afọ (ndị ọzọ Pseudomonas kpatara). Yiri hara

7.5 mg / n'arọ / ụbọchị e kewara 2 doses (nke na ndị okenye nhata 250 mg ugboro abụọ n'ụbọchị).

Ngụkọta ọnụọgụ nke amikainin pui na-arụ ọrụ ezinazu akwara ọrụ (nwechara nke creatinine)

Dodoụbiga ya ókè

Mgbaàmà: mmeghachi omume nsi (nfu ịnụ ntị, ataxia, dizzness, nsogbu nke urination, akpịrị ịkpọ nkụ, agụụ, agụụ, ọgbụgbọ, mkpọtụ ma ọ bụ mmetụta nke nri na ntị, ọdịda iku ume).

Ọgwụ: iji wepu mgbochi nke mgbasa neuromuscular na nsonaazụ ya - hemodialysis ma ọ bụ peritoneal dialysis, ọgwụ anticholinesterase, sọlfọ, ikuku nke ikuku, usoro ndị ọzọ na usoro nkwado.

Mmekọrịta na ọgwụ ndị ọzọ

Ekwesịrị izere sistemu sistemu ma ọ bụ mpaghara na ọgwụ ndị ọzọ nwere ike nephrotoxic ma ọ bụ ọgwụ ototoxic n'ihi nsonye na-esote mmetụ. Mmụba na nephrotoxicity na-apụta na nchịkwa nkwonkwo nke aminoglycosides na cephalosporins. Con na-ejikọ ya na cephalosporins nwere ike ịba ụba ọbara ọbara creatinine mgbe ekpebisi ike. Ihe ọghọm nke ototoxicity na-abawanye site na iji ọgwụ amikacin na-eme ngwa ngwa na-eme ihe na-eme ngwa ngwa, ọkachasị mgbe a na-elekọta ya n'ọrịa ọbara. Diuretics nwere ike iwelie toinors nke aminoglycosides ruo na-enweghị mgbanwe ototoxicity n'ihi mgbanwe na mkpokọta nke ọgwụ nje na ọbara ọbara na anụ ahụ. Ndị a bụ furosemide na ethaclates acid, nke n'onwe ya bụ ọgwụ ototoxic.

Achọghị nchịkwa intraperitoneal nke amikacin na ndị ọrịa n’okpuru mmetụta nke ọgwụ akụnwụ ahụ ma ọ bụ ọgwụ na-eme ka ahụ ghara iru ala (gụnyere ether, halothane, D-tubocurarine, succinylcholine na decametonium), mgbochi neuromuscular na ụdi iku ume na-esote nwere ike ime. ,

Indomethacin nwere ike ịbawanye ụba nke amikacin na plasma n'ime ụmụ amụrụ ọhụrụ.

N'ime ndị ọrịa nwere nnukwu nsogbu akụrụ, mbelata nke ọrụ aminoglycoside nwere ike ịda site na iji ọgwụ penicillin mee ihe.

Riskbawanye n'ihe egwu nke ihu abụọ na nchịkwa nkwonkwo nke aminoglycosides na bisphosphonates.

Riskbawanye n'ihe ize ndụ nke nephrotoxicity na ikekwe ototoxicity na nchịkwa nkwonkwo nke aminoglycosides nwere ogige platinum.

Ingsdọ aka na ntị na nchedo pụrụ iche

Jiri mkpachapụ anya na ndị ọrịa nwere akụrụ gbasara akwara, ma ọ bụ mebie nke ntị ma ọ bụ ngwa vestibular. Ekwesịrị inyocha ndị ọrịa anya n'ihi ike pụrụ iche na nephrotoxicity nke aminoglycosides. Ewubeghi nchekwa maka oge ọgwụgwọ karịa ụbọchị 14. Ekwesịrị ileba anya na usoro onunu ogwu na ikuku kwesịrị ekwesị.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa ma ọ bụ mbelata nke ịlọ ụwa, ọrụ akụrụ ga-enyocha ụzọ usoro tupu ọgwụgwọ yana oge site n'oge ọgwụgwọ. Ekwesịrị ibelata usoro ọgwụ kwa ụbọchị yana / ma ọ bụ oge dị n'etiti ntụtụ ga-agbatị na usoro nlebara ọbara ọbara iji zere mkpokọta ọkwa dị ukwuu na ọbara ma belata ihe ize ndụ nke ototoxicity. Ileba anya n'ihe gbasara ọgwụ na ọrụ gbasara akụrụngwa dị ezigbo mkpa na ndị agadi nwere ike ịbelata ọrụ gbasara akụrụngwa enwere ike, nke nwere ike ọgaghị apụta na nsonaazụ nyocha oge niile dị ka urea ọbara na serum creatinine.

Ọ bụrụ na ọgwụgwọ ahụ ga-adị ụbọchị asaa ma ọ bụ karịa na ndị ọrịa nwere akụrụ gbasara akwara, ma ọ bụ ụbọchị iri na ndị ọrịa ndị ọzọ, a ga-enwetakwa data audiogram mbụ ma tụleghachi n'oge ọgwụgwọ. Ekwesịrị ịkwụsị ọgwụ Amikacin ma ọ bụrụ na inwe mmetụta uche nke tinnitus ma ọ bụ ọnwụ ịnụ na-etolite, ma ọ bụ ma ọ bụrụ na ihe nkiri na-esote ya na-egosi mbelata dị ukwuu na nghọta nke ugboro ugboro.

Ọ bụrụ n ’ihe ịrịba ama nke mgbakasị akwara akụrụ (dịka ọmụmaatụ, albuminuria, mkpụrụ ndụ ọbara uhie ma ọ bụ lymphocytes), ekwesịrị ịba ụba nke hydration ma belata ị doụ ọgwụ ahụ. Ọrịa ndị a na-apụ n'anya mgbe ọgwụgwọ zuru ezu. Agbanyeghị, ọ bụrụ na azotemia na / ma ọ bụ mbelata mmụpụta mmamịrị pụtara, ekwesịrị ịkwụsị ya.

Neuro / Ototoxicity. Neurotoxicity, gosipụtara n'ụdị nke vestibular na / ma ọ bụ audtoory ototoxicity, nwere ike ime na ndị ọrịa na-anata aminoglycosides. Ihe ọghọm nke aminoglycoside na-akpata ototoxicity dị ukwuu n’arụ ndị ọrịa nwere nsogbu gbasara akụrụngwa, yana mgbe ị na-anata usoro ọgwụgwọ dị elu, ma ọ bụ oge ọ ga-anọnyere ọgwụgwọ karịrị ụbọchị asaa. Dizzness nke nwere ike igosi mmebi vestibular. Ihe ngosipụta ndị ọzọ nke neurotoxicity nwere ike ịgụnye ọnya, ịmịkpọ nke anụ ahụ, ịmịkọta akwara, na ntagide. Ihe ọghọm nke ototoxicity na-abawanye site na ịbawanye ụba na-ekpughe ya ma ọ bụrụ na ọ na-anọkarị elu ma ọ bụ na ọnụnọ ike dị ukwuu. Ojiji nke amikacin na ndị ọrịa nwere nfụkasị aminoglycosides, ma ọ bụ mmerụ subclinical renal, ma ọ bụ mmebi nke akwara nke asatọ site na nchịkwa mbido nke nephrotoxic na / ma ọ bụ ọgwụ ototoxic (streptomycin, dihydrostreptomycin, gentamicin, tobramycin, kanamycin, kanamycin B polyinomycin, , cephaloridine, ma ọ bụ viomycin) kwesịrị iji nlezianya tụlee ya, ebe enwere ike ịkwalite nsị. N'ime ndị ọrịa a, a na-eji amikacin eme ihe ma ọ bụrụ na, dị ka dọkịta si kwuo, uru ọgwụgwọ ọgwụgwọ karịrị ihe ọ bụla nwere ike ịdaba.

Ọkpụkpụ nke akwara ozi. Edere ihe mgbochi neuromuscular na mkpịsị akpa ume mgbe a nwesịrị nlekọta, ikuzi (na usoro orthopedic, ogbugba mmiri nke eriri afọ, ọgwụgwọ nke emyema), na mgbe nchịkwa ọnụ nke aminoglycosides. Enwere ike ịtụle ahụike nke akụkụ okuku ume na ntinye nke aminoglycosides n'ụzọ ọ bụla, ọkachasị ndị ọrịa na-anata mgbatị, akwara umeji (tubocurarine, succinylcholine, decametonium), ma ọ bụ na ndị ọrịa na-anata oke mmịnye nke ọbara citrate-anticoagulated. Ọ bụrụ na mgbochi neuromuscular emee, sọlfọ a na - ewepụ ahịrị akụkụ okuku ume, ma ikuku ikuku nwere ike ịdị mkpa. Ekwesịrị iji aminoglycosides jiri nlezianya mee ihe na ndị ọrịa nwere nkwarụ akwara (myasthenia gravis ma ọ bụ parkinsonism), ebe ha nwere ike ịka ike adịghị ike n'ihi nsonaazụ curariform nwere ike ịfe na neuromuscular.

Nrụrụ aka ntaramahụhụ. Aminoglycosides nwere ike nephrotoxic. Ihe ọghọm nke ịmalite ọrịa nephrotoxicity dị elu na ndị ọrịa nwere ọrụ gbasara akụrụngwa, yana mgbe ha na-anata usoro ọgwụgwọ dị elu na ogologo oge. Achọrọ ezigbo hydration n'oge ọgwụgwọ; ekwesịrị ịchọpụta ọrụ akụrụ site na iji usoro ọgwụgwọ tupu yana mgbe ọgwụgwọ. A ga-akwụsị ịgwọ ya na mmụba azotemia ma ọ bụ mbelata mmamịrị na-aga n'ihu.

N'ime ndị ọrịa agadi, mbelata ọrụ ọrụ akụrụ ga-ekwe omume, nke nwere ike ọ gaghị apụta ìhè na ule nyocha umu anumanu (serum nitrogen urea ma ọ bụ serum feathein). Eterchọpụta nyocha nke creatinine nwere ike ịba uru karịa n'ọnọdụ ndị a. Nyochaa ọrụ gbasara akụrụngwa na ọrịa ndị agadi n'oge ọgwụgwọ aminoglycosides dị ezigbo mkpa.

Ọrụ ntaramahụhụ na akwara cranial nke asatọ chọrọ nyocha na ndị ọrịa a maara ma ọ bụ na-eche na ezigharị akụrụ na mbido ọgwụgwọ, yana ndị ọrịa nwere ibido ọrụ ezumike nkịtị, mana ya na akara nke arụ ọrụ ezigharị n'oge a na-agwọ ya. A ga-enyocha ntụpọ Amikacin iji hụ na usoro ọgwụgwọ zuru oke yana iji zere ọkwa nwere ike ịmetụta ya. Ekwesịrị ileba anya na-eme ka anwụ na-ebelata oke ọrụ, ike ịmịpụrụ protin, na erythrocyturia. Ekwesịrị tụọ urea ọbara, serum creatinine, ma ọ bụ nwechapụ ya site n'oge ruo n'oge. Ekwesịrị inweta usoro ihe omume ana - eme ka ndị agadi agadi, ọkachasị n’ebe ndị ọrịa nọ n'ihe ize ndụ dị. Ihe nrịba ama nke ototoxicity (dizzness, tinnitus, tinnitus and ear cure) ma ọ bụ nephrotoxicity chọrọ ịkwụsị ọgwụ ma ọ bụ mmezi dose.

Ekwesịrị izere n'otu oge na / ma ọ bụ usoro nke ọgwụ neurotoxic ndị ọzọ ma ọ bụ nephrotoxic (bacitracin, cisplatin, amphotericin B, cephaloridin, paromomycin, viomycin, polymyxin B, colistin, vancomycin, ma ọ bụ aminoglycosides ndị ọzọ). Ihe ndị ọzọ na-abawanye n'ihe ize ndụ nke nsi egbu egbu bụ ịka nká na akpịrị ịkpọ nkụ.

Misc Aminoglycosides na-agbakarị ngwa ngwa ma ọ fọrọ nke nta ka etinye ya kpamkpam mgbe etinyere ya na elu, yana yana usoro ịwa ahụ. A kọwo nti ntị chiri, mmebi akụrụ, na ọnwụ n'ihi mgbochi nke neuromuscular n'oge a na-agba mmiri nke nnukwu na obere mpaghara ịwa ahụ.

Dịka ọgwụ nje ndị ọzọ, iji amikacin nwere ike ibute nnukwu uto nke microorganisms. N'okwu a, ekwesịrị inye ọgwụ ọgwụgwọ kwesiri ekwenye.

A kọwo ọrịa nke ọhụụ na-enweghị atụ ọhụụ mgbe ịgba ọgwụ amikacin banye na anya.

Mwepụta wepụtara ya na ihe mebere

A na-enye ọgwụ ọgwụ n'ụdị:

• Ngwọta ezubere maka nchịkwa m / m na iv, 1 ml nke nwere 250 mg nke amikacin, na ampoules nke 2 na 4 ml,
• A na-edozi ntụ ntụ nke esi dozie ụzọ ntụtụ, n'otu karama (10 ml) nke nwere ike ịnwe 250 mg, 500 mg ma ọ bụ 1 gram nke amikacin.

Ihe ngbanwe

Dabere na nkọwa banyere ọgwụ a, a na-egbochi ojiji nke Amikacin:

• Womenmụ nwanyị dị ime
• Na neuritis nke akwara ozi,
• Ndị ọrịa nwere nnukwu akụrụ gbasara akwara na-esochi uremia na / ma ọ bụ azotemia,
• Na ọnụnọ nke ọgwụ amikacin, akụrụngwa inyeaka ọ bụla nke ọgwụ ahụ, aminoglycosides ndị ọzọ (gụnyere akụkọ).

Edere Amikacin, mana enwere nnukwu nlekọta na nlekọta nlekọta ahụike mgbe niile:

• Na akpịrị ịkpọ nkụ,
• Mụ nwanyị n'oge a na-enye nwa ara
• Na myasthenia gravis,
• Oria nwere oria
• Na okpu gbasara akwara,
• Mụ amụrụ ọhụrụ na ụmụ ime afọ,
• Ndị okenye
• Na botulism.

Usoro onunu ogwu na ochichi Amikacin

Ngwọta (gụnyere nke a kwadebere na ntụ ntụ) Amikacin, dị ka ntuziaka a si dị, a ga-enye ya intramuscularly ma ọ bụ intravenously.

Ọgwụ maka ndị okenye na ụmụaka karịrị afọ 6 bụ 5 mg kwa kilogram nke ịdị ahụ, nke a na-ahụ na oge nke awa 8, ma ọ bụ 7.5 mg / kg kwa awa 12. Site na nje ọrịa na-adịghị agbanwe agbanwe nke ọnya mkpụrụ ndụ, ọ ga-ekwe omume ị aụ ọgwụ n'ime ọgwụ 250 mg kwa awa iri na abụọ ọ bụla. Ọ bụrụ na ịchọrọ nnọkọ hemodialysis mgbe ọ gasịrị, ị nwere ike ịme ntụtụ ọzọ na ọnụego nke 3-5 mg kwa 1 n'arọ nke ibu.

Oke kachasị anabata ọgwụ maka ndị okenye kwa ụbọchị bụ 15 mg / n'arọ, mana ọ bụghị ihe karịrị 1.5 gram kwa ụbọchị. Oge ọgwụgwọ, dịka iwu, bụ ụbọchị 3-7 - ya na ntinye, ụbọchị 7-10 - ya na / m.

Edere Amikacin maka ụmụaka dịka ndị a:

• Matmụ amụrụla ime: ọgwụ nke mbụ bụ 10 mg kwa n'arọ, mgbe ahụ 7.5 mg / n'arọ kwa awa 18-24,
• Maka ụmụ amụrụ ọhụrụ na ụmụ ọhụrụ ruo afọ 6: usoro mbụ bụ 10 mg / n'arọ, mgbe ahụ 7.5 mg / kg kwa awa 12.

N'ihe banyere okpukpo ọkụ a na-ebute ọrịa, n'ihi obere ndụ amikacin dịkarịa ala na ndị ọrịa a, ị theụ ọgwụ ahụ na-abụkarị 5-7.5 mg / n'arọ, mana ugboro ugboro nke nchịkwa na-abawanye - awa 4-6.

A na-etinye Amikacin n'ọbara n'ụzọ karịrị minit 30-60. N'ọnọdụ chọrọ ngwa ngwa, a na-ahapụ irigbu jet maka nkeji abụọ.

Maka nchịkwa mgbochi intravenous, a na-agwakọta ọgwụ ahụ na 0.9% sodium chloride solution ma ọ bụ 5% dextrose solution ka itinye uche nke ihe ahụ na-arụ ọrụ ghara gafere 5 mg / ml.

Mbelata dose ahụ ma ọ bụ nwekwuo oge n'etiti injections chọrọ ndị ọrịa nwere nsogbu ezumike nri ha nwere nsogbu.

Nsonaazụ nke Amikacin

Dabere na nyocha nke ndị ọrịa na-eji Amikacin ọgwụgwọ, ọgwụ a nwere ike inwe mmetụta ndị ọzọ, dịka:

• Vomiting, ọgbụgbọ, na-arụ ọrụ imeju.
• Leukopenia, thrombocytopenia, anaemia, granulocytopenia,
• Mkpọnwụ isi, isi ọwụwa, mgbasa akwara ozi (akụkụ iku ume), mmepe nke mmetụta neurotoxic (imechi ọnya, ọnya, ihe mgbu, nsogbu ọdịdọ),
• Ntị ịnụ ntị, nti ntị a na-apagharị idogharị ya, ihe nlere na enweghị ike,
• Oliguria, microredituria, proteinuria,
• Mmeghachi omume nfụkasị: akpụkpọ ahụ akpịrị, ọnya, ahụ ọkụ, itching, edere nke Quincke.

Na mgbakwunye, na nchịkwa intravenous Amikacin, dị ka nyocha si kwuo, mmepe nke phlebitis, dermatitis na periphlebitis, yana mmetụta mgbu na saịtị ịgba ahụ, ga-ekwe omume.

Ntụziaka pụrụ iche

Tupu ị theụ ọgwụ ahụ, ọ dị mkpa iji chọpụta nzere nke pathogens ahọpụtara na ya.

N'oge ọgwụgwọ Amikacin, ọbụlagodi otu ugboro n'izu, a ga-enyocha ọrụ nke akụrụ, akwara vestibular na akwara auditory.

Amikacin enweghị ọgwụ ọgwụ nje B na C, cephalosporins, penisiliniins, nitrofurantoin, potassium chloride, erythromycin, hydrochlorothiazide, capreomycin, heparin, amphotericin B.

Ndị ọrịa a na-anara ọgwụgwọ maka ọrịa na-efe efe na mkpali nke ọrịa urinary kwesịrị ị drinkụ ọtụtụ mmiri (nyere diureis zuru oke).

Ekwesịrị iburu n'uche na iji ogologo oge nke Amikacin, mmepe nke microorganisms na-eguzogide ọgwụ ga-ekwe omume. Yabụ, na enweghị mgbanwe ọgwụ dị egwu, ọ dị mkpa ịkagbu ọgwụ a ma duzie ọgwụgwọ kwesịrị ekwesị.

Amikacin analogues

Amikacin-system analogues are Amikacin-Ferein, Amikacin-Vial, Amikacin Sulfate, Amikin, Amikabol, Selemicin, Hemacin.

Site na otu otu ọgwụ ọgwụ na myirịta nke usoro nke ime ihe, a pụrụ ịtụle ọgwụ ndị na-esote analogues nke Amikacin: Bramitob, Gentamicin, Kanamycin, Neomycin, Sisomycin, Florimycin sulfate, wdg.

Usoro na ọnọdụ nchekwa

Amikacin bụ ọgwụ nje B nke ndị ọgwụ nyere site na ọgwụ. Ndụ shelf bụ afọ 2 na-agbaso iwu nchekwa nke onye nrụpụta tụrụ aro ya - ọnọdụ 5-25 ºС, ebe akọrọ na ọchịchịrị.

Hụrụ njehie na ederede? Họrọ ya wee pịa Ctrl + Tinye.

Leasedị mwepụta, nkwakọ ngwaahịa na ihe eji eme Amikacin

Ngwọta maka nchịkwa intramuscular bụ transperent, enweghị agba ma ọ bụ nke dị obere.

Ndị pụrụ iche: sodium disulfite (sodium metabisulfite), sodium citrate d / i (sodium citrate pentasesquihydrate), sọlfọ acid a gwakọtara, mmiri d / i.

2 ml - ampoules iko (5) - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
2 ml - ampoules iko (5) - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu.
2 ml - ampoules iko (10) - ngwugwu na-acha uhie uhie (1) - ngwugwu nke kaadiboodu.
2 ml - ampoules iko (10) - igbe kaadiboodu.

Ngwọta maka nchịkwa intramuscular bụ transperent, enweghị agba ma ọ bụ nke dị obere.

Ndị pụrụ iche: sodium disulfite (sodium metabisulfite), sodium citrate d / i (sodium citrate pentasesquihydrate), sọlfọ acid a gwakọtara, mmiri d / i.

4 ml - iko ampoules (5) - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
4 ml - iko ampoules (5) - ngwugwu ọnya (2) - ngwugwu nke kaadiboodu.
4 ml - iko ampoules (10) - ngwugwu ọnya (1) - ngwugwu nke kaadiboodu.
4 ml - iko ampoules (10) - igbe kaadiboodu.

Ngwakọta ntụ ntụ maka nkwadebe nke ihe ngwọta maka nchịkwa intravenous na intramuscular nke ọcha na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha bụ hygroscopic.

Karama nwere ikike nke 10 ml (1) - ngwugwu nke kaadiboodu.
Karama nwere ikike nke 10 ml (5) - ngwugwu nke kaadiboodu.
Karama nwere ikike nke 10 ml (10) - ngwugwu nke kaadiboodu.

Mmegha nke otu nosological

Ọnụ ahịa ahịa ọgwụ na Moscow

Hapụ okwu gị

Nchọpụta Ozi Ugbu A, ‰

Aha ọgwụ dị mkpa yana ọgwụ ndị dị mkpa

Asambodo ndenye aha Amikacin

• P N001175 / 01

• LP-003317

• LP-004398

• LP-003391

• LSR-002156/09

• LSR-002348/08

• LS-000772

• LSR-006572/09

• P N003221 / 01

• S-8-242 N008784

• S-8-242 N008266

Ndị ọrụ gọọmenti webụsaịtị nke ụlọ ọrụ RLS ®. Nnukwu akwụkwọ nkà ihe ọmụma nke ọgwụ na ngwongwo nke ọgwụ ahịa ọgwụ nke Internetntanetị Russia. Ndepụta ọgwụ ọgwụ Rlsnet.ru na-enye ndị ọrụ ohere ịnweta ntuziaka, ọnụahịa na nkọwapụta ọgwụ, nri nri, ngwaọrụ ọgwụ, ngwaọrụ ọgwụ na ngwaahịa ndị ọzọ. Ntuziaka pharmacological gunyere ozi banyere ihe mejupụtara na ụdị ntọhapụ, ihe ndị a na-eme ọgwụ, na-egosi iji ya, contraindications, mmetụta ndị dị na ya, mmekọrịta nke ọgwụ, ụzọ iji ọgwụ, ụlọ ọrụ ọgwụ. Akwụkwọ ndekọ ọgwụ ahụ nwere ọnụ ahịa ọgwụ na ngwaahịa ọgwụ na Moscow na obodo ndị ọzọ Russia.

Amachibidoro ịnyefe, detuo, kesaa ozi na enweghị ikike nke RLS-Patent LLC.
Mgbe ị na-ehota ihe ederede nke edepụtara na ibe saịtị ahụ: www.rlsnet.ru, njikọ ga-enweta isi mmalite ozi a chọrọ.

Ọtụtụ ihe ndị ọzọ na-adọrọ mmasị

Ikike niile echekwabara.

Anaghị anabata iji ihe azụmaahịa.

Ezubere ozi a maka ndị ọrụ ahụike.

Ngwongwo ogwu

Mlọ ọgwụ

Mgbe nchịkwa intramuscular (IM), ọ na-abanye ngwa ngwa na kpamkpam. Oke ntinye uche (Cmax) ya na nchịkwa m / m na ọgwụ nke 7.5 mg / kg bụ 21 μg / ml. Oge ị ga - eji nweta oge ịta (TCmax) bụ ihe dịka 1.5 awa mgbe nchịkwa m. Nkwurita okwu na protein protein - 4-11%.

A na-ekesa ya nke ọma na mmiri extracellular (ọdịnaya nke etuto, ihe na -akasị anụ ahụ, ascitic, pericardial, synovial, lymphatic and peritoneal fluid), a na-ahụ ya anya na oke mmamịrị, dị ala - na bile, mmiri ara ara, ihu ọchị nke anya, ihe gbasara akwara ozi, sputum na eriri azụ mmiri mmiri (CSF). Ọ na-abanye nke ọma na akwara niile nke anụ ahụ ebe ọ na-agbakọta intracellularly, a na-ahụ ihe ndị dị elu na akụkụ ahụ nwere ọbara dị mma: akpa ume, imeju, myocardium, na akụrụ na akụrụ, ebe ọ na-agbakọ na oyi akwa cortical, mkpụkọ dị ala - na akwara, anụ ahụ adipose na ọkpụkpụ .

Mgbe etinyere ya na usoro ọgwụgwọ oke (kwesịrị) maka ndị okenye, amikacin anaghị abanye na mgbochi ụbụrụ ọbara (BBB), yana ọnya iwe nke meninges, permeability na-abawanye ntakịrị. N'ime ụmụ amụrụ ọhụrụ, a na-enwetara ohere dị elu na CSF karịa na ndị okenye, na-agafe na Plasenta - a hụrụ n'ọbara nke nwa ebu n'afọ na mmiri ọmụmụ. Olu nkesa na ndị okenye - 0.26 l / n'arọ, n'ime ụmụaka - 0.2 - 0.4 l / n'arọ, na ụmụ amụrụ ọhụrụ - na-erubeghị afọ 1. na ahụ gị erughị 1.5 n'arọ - ihe ruru 0.68 l / n'arọ, nke na-erughị izu 1. na ahụ ha karịrị 1.5 n'arọ - ihe ruru 0,58 l / n'arọ, n'ime ndị ọrịa nwere ọrịa fibrosis - 0.3 - 0.39 l / n'arọ. A na-ejigharị ọnụọgụ ọgwụgwọ maka mmekọrịta akwara ma ọ bụ nchịkwa intramuscular maka elekere 10-12.

Emeghị metabolized. Ọkara ndụ (T1 / 2) na ndị okenye bụ awa 2 ruo 4, na ụmụ amụrụ ọhụrụ bụ awa ise ruo asatọ, na ụmụaka gbara afọ bụ awa 2.5 ruo awa 4. T1 / 2 nke ikpeazu karịrị 100 awa (eweputara na depot intracellular. )

Ọ kpụrụ ya akụrụ site na nzacha ụwa (65 - 94%), ọkachasị adịghị agbanwe agbanwe. Mkpochapu ntaramahụhụ - 79-100 ml / min.

T1 / 2 n'ime ndị okenye nwere ọrụ gbasara akụrụ na-arụ ọrụ dịgasị iche dabere na ogo nke nkwarụ - ruo 100 awa, n'ime ndị ọrịa nwere cystic fibrosis - 1 - 2 awa, n'ime ndị ọrịa nwere ọnya na ọbara mgbali elu, T1 / 2 nwere ike ịdị mkpụmkpụ karịa nkezi n'ihi mmụba dị elu n'ihi mmụkọ nwekwuo ya. .

A na - apịpụta ya n'oge a na - agwọ ọrịa (50% na 4 - 6 awa), ọgwụgwọ ọrịa peritoneal adịghị arụ ọrụ (25% na 48 - 72 awa).

Mlọ ọgwụ

Mkpụrụ ọgwụ mgbochi ọrịa nke dị obere nke na-eme ka nje bacteria na-arụ ọrụ.Site na itinye 30S nke ribosomes nke 30S, ọ na-egbochi ịmepụta njem nke ụgbọ njem na onye ozi RNA, na-egbochi mkpokọ protein, ma na-ebibakwa membranes cytoplasmic nke nje.

Arụ ọrụ nke ukwuu megide microorganisms nke aerobic gram-Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Grafọdụ micromgangan gram-positive-staphyloccus spp. (gụnyere ndị na-eguzogide ọgwụ penisilini, ụfọdụ cephalosporins), na-arụ ọrụ ike ruo n'ókè megide Streptococcus spp.

Site na nchịkwa nke oge a na benzylpenicillin, ọ nwere mmetụta synergistic megide njikọta Enterococcus faecalis.

Ọ dịghị emetụta microorganisms anaerobic.

Amikacin anaghị arụ ọrụ n'okpuru ọrụ nke enzymes na-eme ka aminoglycosides ndị ọzọ na-arụ ọrụ, ma nwee ike ịnọgide na-arụ ọrụ megide ụdị Pseudomonas aeruginosa na-eguzogide tobramycin, gentamicin na netilmicin.

Mkparịta ụka ọgwụ ọjọọ

Ọ bụ nke ọgwụ ekwekọghị na penisiliniins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, vitamin B na C, na chloride potassium.

Ọ na-egosi synergism mgbe ya na carbenicillin, benzylpenicillin, cephalosporins (na ndị ọrịa nwere nnukwu akwara na-adịghị ala ala, mgbe ejikọtara ya na ọgwụ mgbochi beta-lactam, ịdị mma nke aminoglycosides nwere ike ibelata). Nalidixic acid, polymyxin B, cisplatin na vancomycin na-amụba ohere nke oto- na nephrotoxicity.

Diuretics (ọkachasị furosemide, ethaclates acid), cephalosporins, penisiliniins, sulfonamides na ọgwụ mgbochi na-abụghị steroid, na-asọ mpi maka nzuzo ọrụ na nephron tubules, na-egbochi ikpochapụ aminoglycosides ma na-abawanye itinye uche ha na ọbara ọbara, na-abawanye nephro- na neurotoxicity.

Ekwesịrị iji otu oge a na ọgwụ ndị ọzọ nwere ike nephrotoxic ma ọ bụ ọgwụ ototoxic n'ihi ohere nke nsonaazụ ndị ọ bụla.

Egosiwo mmụba nke nephrotoxicity mgbe nchịkwa nnabata nke aminoglycosides na cephalosporins. Ce na-ejikarị cephalosporins nwere ike ịba ụba serin creatinine.

Na-eme ka uru ahụ dị jụụ nke ọgwụ curariform.

Methoxyflurane, polymyxins parenteral, capreomycin, na ọgwụ ndị ọzọ na-egbochi nnyefe neuromuscular (halogenated hydrocarbons dị ka anesthetics inhalation, opioid analgesics), na mmịnye ọbara dị ukwuu na nchekwa nke citrate na-eme ka ohere nke njide okuku.

Nlekọta Parenteral nke indomethacin na-abawanye ohere nke nsonaazụ nke aminoglycosides (mmụba na ọkara ndụ na belata nwepu).

Na-ebelata mmetụta nke ọgwụ myasthenic.

Enwere ihe dịwanye elu nke ihu abụọ na nchịkwa nke aminoglycosides na bisphosphonates. Ihe ọghọm nke nephrotoxicity na ikekwe ototoxicity ga-ekwe omume na njikọta aminoglycosides na nkwadebe platinum.

Site na nhazi nke sistem (vitamin B1), enwere ike imebi ihe sodium bisulfite na amikacin sulfate mejupụtara.

Mwepụta wepụtara na nkwakọ

Mpempe 500 nke ihe na-arụ ọrụ n'ime karama ahụ ji roba ndị ejiri ọgwụ eji ekpuchi roba, jiri okpu aluminom wee ma okpu "FLIPP OFF".

Mpempe akwụkwọ ejiri mpempe akwụkwọ ma ọ bụ ihe edere ede na-agbanye na karama ọ bụla, ma ọ bụ butere mpempe onwe-nrapado na ya

A na-etinye karama ọ bụla, yana ntuziaka akwadoro maka ojiji ahụike na asụsụ obodo na Russian, na igbe kaadi.

Ngosipụta nke ọgwụ Amikacin

Ọrịa na-efe efe na-akpata site na microorganisms gram-na-adịghị mma (na-eguzogide ọgwụ nke sitamicin, sisomycin na kanamycin) ma ọ bụ mkpakọrịta nke microorganisms gram-gram na-adịghị mma.

• ọrịa okuku ume na akwara na akwara (ọnya afọ, oyi baa, nsogbu nke akpa ume, akpa ume),
• sepsis
• oria endocarditis,
• Ọrịa CNS (gụnyere meningitis),
• ofufe ọrịa nke eriri afọ (gụnyere peritonitis),
• ọrịa urinary na-efe efe (pyelonephritis, cystitis, urethritis),
• ọnya na-efe efe nke anụ ahụ na anụ ahụ dị nro (gụnyere ọnya na-ere ọkụ, ọnya na ọrịa mgbali dị iche iche),
• ọrịa biliary tract
• ọrịa nke ọkpụkpụ na nkwonkwo (gụnyere osteomyelitis),
• ọnya ọrịa
• ọrịa na-efe efe postolowo.

Usoro usoro onunu ogwu

A na-ahụ maka ọgwụ ahụ intramuscularly, intravenously (n'ime jet, maka nkeji 2 ma ọ bụ ntapu) maka ndị okenye na ụmụaka karịrị afọ 6 - 5 mg / kg kwa awa 8 ma ọ bụ 7.5 mg / kg kwa awa 12. N'ihe banyere nje nje nke urinary tract ( agbagọ) - 250 mg kwa elekere 12 ọ bụla, mgbe emesịrị ịba ọcha n'anya, enwere ike inye ọgwụ mgbochi ọzọ nke 3-5 mg / kg.

Oke kachasị maka ndị okenye bụ 15 mg / kg / ụbọchị, mana ọ karịghị 1.5 g / ụbọchị maka ụbọchị 10. Ogologo oge ọgwụgwọ ya na a / na ntinye bụ ụbọchị 3-7, yana ụbọchị / m - 7-10.

Maka ụmụ amụrụ ọhụrụ, otu ụzọ izizi bụ 10 mg / kg, mgbe ahụ 7.5 mg / n'arọ kwa awa 18-24, maka ụmụ amụrụ ọhụrụ na ụmụaka na-erubeghị afọ 6, ọgwụ mbụ bụ 10 mg / kg, mgbe ahụ 7.5 mg / kg ọ bụla 12 h maka ụbọchị 7-10.

N'ime ọkụ ọgbụgba, oria 5-7.5 mg / kg kwa awa 4-6 nwere ike ịchọrọ n'ihi mkpụmkpụ T 1/2 (awa 1-1.5) na ndị ọrịa.

A na-eji amamacin abanye / na amikacin maka nkeji 30-60, ọ bụrụ na ọ dị mkpa, site na jet.

Maka nchịkwa iv (drip), ọgwụ na-ebu ụzọ jiri 200 ml nke 5% dextrose (glucose) edozi ma ọ bụ 0.9% sodium chloride solution. Ntinye uche nke amikacin na mmezi maka ochichi iv ekwesịghị gafere 5 mg / ml.

Ọ bụrụ na arụrụ ọrụ ezumike ezumike ezumike, mbelata dose ma ọ bụ mmụba n'etiti oge dị n'etiti ọchịchị ndị dị mkpa. N'ihe banyere mmụba na etiti oge nke nchịkwa (ọ bụrụ na amabeghi na uru QC adịghị, na ọnọdụ onye ọrịa kwụsie ike), etinyere nkeji oge n'etiti nchịkwa ọgwụ site n'ụkpụrụ a:

nkeji oge (h) = serum creatinine ịta × 9.

Ọ bụrụ na itinye uche nke serum creatinine bụ 2 mg / dl, mgbe ahụ a ga-enyerịrị otu mkpụrụ ọgwụ a tụrụ aro (7.5 mg / n'arọ) kwa awa 18. Site na mmụba na nkeji oge, a naghị agbanwe otu mmiri.

N'ihe banyere mbelata nke otu mkpụrụ ọgwụ nwere usoro ọgwụgwọ dosing na-agbanweghi, usoro izizi maka ndị ọrịa nwere akwara ezumike bụ 7.5 mg / kg. Ngụkọta nke usoro onodu ogwu a na -eme dị ka usoro a si dị:

Subsequhe na-esote (mg), a na-elekọta kwa awa iri abụọ na abụọ = KK (ml / min) na onye ọrịa × ọgwụ mbụ (mg) / KK bụ ihe dị mma (ml / min).

Mmetụta akụkụ

Site na usoro digestive: ọgbụgbọ, ọgbụgbọ, ọrụ imeju na-arụ ọrụ (ụba ọrụ nke ọrịa hepatic transaminases, hyperbilirubinemia).

Site na sistemụ hemopoietic: anaemia, leukopenia, granulocytopenia, thrombocytopenia.

Site n'akụkụ nke sistemụ akwara na akụkụ akwara: isi ọwụwa, iro ụra, mmetụta neurotoxic (ntugbu akwara, ọnya na-eme mkpọtụ, ọnya na-egbu egbu), nfe na-emegharị neuromuscular (njide akụkụ iku ume).

Site na akwara anụ ahụ: ototoxicity (ọnwụ ịnụ, vestibular na nsogbu labyrinth, ntị chiri agbagha), nsonaazụ na-emetụta ngwa ọrụ vestibular (ịchọpụta mmegharị, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ, ọgbụgbọ).

Site na usoro urinary: nephrotoxicity - arụ ọrụ ezughị ezu ọrụ (oliguria, proteinuria, microredituria).

Mmeghachi omume nfụkasị: ọnya ọnya, itching, akpọnwụ akpịrị, ahụ ọkụ, ọnya Quincke.

Mmeghachi omume mpaghara: ihe mgbu na saịtị ịgba ahụ, dermatitis, phlebitis na periphlebitis (ya na nchịkwa iv).

Ime na lactation

A na-egbochi ọgwụ a n'afọime.

N'ihu ihe ngosi di nkpa, enwere ike iji ogwu ahu mee ihe na umu nwanyi. Ekwesịrị iburu n'uche na aminoglycosides na-apụ apụ na mmiri ara ara obere obere. Ha na-agbasochasị akụkụ eriri afọ, yana edeghị nsogbu metụtara ụmụ ọhụrụ.

Mkparịta ụka ọgwụ ọjọọ

Ọ na-egosi synergism mgbe ya na carbenicillin, benzylpenicillin, cephalosporins (na ndị ọrịa nwere nnukwu akwara na-adịghị ala ala, mgbe ejikọtara ya na ọgwụ mgbochi beta-lactam, ịdị mma nke aminoglycosides nwere ike ibelata).

Nalidixic acid, polymyxin B, cisplatin na vancomycin na-amụba ohere nke oto- na nephrotoxicity.

Diuretics (karịsịa furosemide), cephalosporins, penicillins, sulfanilamides na NSAIDs, na-asọ mpi maka nzuzo nzuzo na tubules nke nephron, na-egbochi ikpochapụ aminoglycosides, na-abawanye itinye uche ha na ọbara ọbara, na-abawanye nephro- na neurotoxicity.

Amikacin na-eme ka uru ahụ dị jụụ nke ọgwụ curariform.

Mgbe ejiri amikacin, methoxyflurane, polymyxins parenteral, capreomycin na ọgwụ ndị ọzọ na-egbochi nnyefe neuromuscular (hacarenated hydrocarbons - inhalation anesthesia, analgesics opioid), nnukwu ọbara ọbara na nchekwa nke citrate na-abawanye ohere nke njide iku ume.

Nlekọta Parenteral nke indomethacin na-abawanye ohere nke nsonaazụ nke aminoglycosides (mmụba na T 1/2 ma belata mwepụ).

Amikacin na-ebelata ịdị irè nke ọgwụ mgbochi myasthenic.

Ọ bụ nke ọgwụ ekwekọghị na penisiliniins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, vitamin B na C, na chloride potassium.