Analogs nke ọgwụ ọgwụ LANerin

Langerin bụ otu n’ime ọtụtụ ọgwụ ọgwụ eji eme ọgwụgwọ maka usoro a na-akpọ ọrịa mellitus na-abụghị insulin. Ọgwụ bụ akụkụ nke ìgwè ọgwụ dị na biguanide, isi ihe dị na ya bụ ibelata mkpa maka mmepụta insulin.

Ọnụahịa nke Langerin dị na ụlọ ahịa ọgwụ, dabere na usoro ịchọrọ, nwere ike ịdị site na otu narị ruo narị atọ rubles.

Langerin bụ ọgwụ mbadamba ọgwụ nke a na-eji eme ihe n’ọrịa dị mgbagwoju anya nke ọrịa shuga. Akụkụ bụ isi ya bụ metformin umi. Ọgwụ bụ otu n'ime ọgwụ ndị na-ebelata shuga, a na-ejikwa ya eme ihe iji mee ka ọ̀tụ̀tụ̀ shuga dị n'ọbara dị na ndị ọrịa mamịrị.

Otu n'ime ọgwụ ndị dị otú ahụ ga-ekwe omume bụ nchịkwa ya ma ọ bụrụ na enweghi ike nke mbadamba ọrụ ndị mbụ ejirila na usoro sulfonylurea. Na mgbakwunye, oke ibu bụ nsogbu concoitant maka mmadụ niile nwere ọrịa shuga.

Ọ bụ ya mere, Langerin na-enye ohere ọ bụghị naanị iwetulata shuga dị ala, kama ọ na-enyekwa aka n’ibelata ịdị arọ nke onye ọrịa.

Ngwongwo ọgwụ na ihe ngosi maka ojiji

Usoro ihe omume nke akụkụ ahụ dị mkpa nke ọgwụ ahụ jikọtara ya na ikike ya ịkwụsị mmechi nke gluconeogenesis, yana usoro nke njikọta abụba n'efu na oxidation abụba n'efu. Onye na-anọchite klas biguanide anaghị emetụta oke insulin wepụtara na ọbara, mana ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe na ịba ụba nke insulin na proinsulin.

Isi ihe dị mkpa na usoro nke mbadamba ihe ndị dị otú a bụ mkpali nke glucose na-eme n’ihu site na mkpụrụ ndụ akwara.

Isi ihe na-egosi maka iji ọgwụ bụ mmepe nke ọrịa shuga na-akpata insulin na mmadụ, ọkachasị enweghị ike nke nri sochiri.

Njirimara ọgwụ ọgwụ dị na Langerin gụnyere:

• na -ewelata ego nke gemoclobinꓼ glycated
• na - egbochi insulin na - egbochi sel nke ọgwụ na insulin homonụ
• ọfụma na-emetụta oke iwu nke profaịlụ akwara nke plasmaꓼ ọbara
• belata cholesterolꓼ nke ojoo

Na mgbakwunye, iji ọgwụ ahụ eme ihe nwere ike ịbelata oke ahụ.

Ntuziaka maka mbadamba mbadamba

Ọgwụ Langerin dị n'ụdị nke mbadamba mkpuchi.

Mbadamba mbadamba ndị ahụ na akpa rọba, nke a na-eji ihe mkpuchi nke aluminom ekpuchi.

A na-etinye akwa n'ime igbe kaadi na ntuziaka maka ojiji nke ọgwụ.

Dabere n’usoro ọgwụ ịchọrọ iji mee ihe, a pụrụ iji ọgwụ were zụta ọgwụ a:

1. 500 milligrams.
2. Milligrams 850.
3. Otu gram nke ihe na-arụ ọrụ.

Ofzọ isi were mbadamba nkume ahụ bụ okwu ọnụ, n'oge nri ma ọ bụ mgbe ọ gachara. Dọkịta na-aga ya depụtara usoro ịgwọ ọrịa maka onye ọrịa ọ bụla n'otu n'otu dabere ogo ọrịa ahụ. Ọzọkwa, ọkachamara n’ihe banyere ọgwụ na-ekpebi ọnụọgụ ọgwụ ole n’otu ọgwụ n’ụbọchị.

Ntụziaka Langerin maka iji mee ihe na-atụ aro ịmalite usoro ọgwụgwọ ọgwụgwọ site na iji obere nke 500 mg nke ọgwụ na-arụ ọrụ. Ọnụ ọgụgụ nke ọgwụ mgbe ụbọchị nwere ike ịbụ otu ruo atọ. Nke nta nke nta, usoro onodi ogwu nwere ike ibuwanye 850 mg nke ihe eji arụ ọrụ ụbọchị dum (otu ugboro ugboro abụọ n'ụbọchị). Dọkịta na-aga ahụ na-enyocha ọnọdụ onye ọrịa ma ọ bụghị ihe karịrị otu ugboro n'izu, na-edozigharị ọnụọgụ ọgwụ agbagoro elu.

Edekwa ọgwụ a maka ịgwọ ọrịa ahụ na ụmụaka karịa afọ iri. Monotherapy kwesịrị ịmalite site na iji ọgwụ nke 500 mg nke ihe ahụ na-arụ ọrụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. Mgbe oge ụfọdụ gasịrị, a na-ekwe ka mmụba nke ọgwụ ahụ nwayọ nwayọ, ma ọ dịghị karịa gram abụọ kwa ụbọchị, kewara abụọ ma ọ bụ atọ.

Dị ka ọ na-adị, mgbanwe n’usoro nke ọgwụ a na-apụta mgbe ụbọchị iri ruo ụbọchị iri na ise dabere na nsonaazụ nyocha ọbara maka ọkwa glucose.

N'ọnọdụ ụfọdụ, ịkwadebe mbadamba ụrọ bụ akụkụ nke ọgwụ ngwakọta na inje insulin.

Okwesiri iburu n'uche na a na-ahụta ochichi nke Langerin nwere insulin, ihe ndị na-eme ka sulfonylurea, acarbose, ma ọ bụ ndị na-egbochi ACE iji mee ka mmetụta hypoglycemic nke ọgwụ ahụ dịkwuo elu.

N'ọnọdụ ụfọdụ, dibịa na-aga ahụ nwere ike iji mbadamba ihe mebere ụdị dochie iji Langerin. Taa, enwere ọtụtụ ọgwụ, ihe bụ isi ọrụ ya bụ metformin.

Ọnụahịa ọgwụ analog nwere ike ịdị iche iche, dabere na ụlọ ọrụ ndị na-emepụta ọgwụ.

Kedu ihe bụ contraindications maka ojiji?

Usoro ọgwụgwọ ahọpụtara n'ụzọ na-ezighi ezi ma ọ bụ na-agbasoghị ndụmọdụ nke dibịa na-aga nwere ike ịkpasu ọdịdị nke mmeghachi omume ọjọọ mgbe ị na-a theụ ọgwụ ahụ.

Na mgbakwunye, enwere oge enwere iji iwu ọgwụ megide metformin amachibidoro.

Ntuziaka maka iji ọgwụ ahụ na-egosi ndepụta nke contraindications kachasị.

Ihe ndi ozo banyere ojiji nke mbadamba Langerin bu ihe ndi a:

• oke nrụrụ imeju ma ọ bụ ọrụ akụrụ, ụkọ ha
• ahoụrụma, gụnyere n'ụdị na-adịghị ala ala
• obi ma ọ bụ iku ume ọdịda
• nnukwu myocardial infarctionꓼ
• Ọnọdụ akpịrị na-arịa ọrịa shuga ma ọ bụ nna nna
• mmepe nke ọrịa mamịrị ụkwụ na-arịa ọrịa shuga
• na ọnụnọ nke nnabata nke mmadụ na metformin yana mmepe nke mmeghachi ahụ nfụkasị ahụ
• ọnụnọ nke ọrịa na-efe efeꓼ
• na-ebu ọnụ na-arịa ọrịa shuga ma ọ bụ na-eso nri nri nke nri ya kwa ụbọchị anaghị aga otu puku kilocaloriesꓼ
• tupu yana mgbe a gbasịrị yaꓼ
• ya na mmerụ ahụ buru ibu na nso nso a
• tupu na mgbe nchọpụta ọrịa na-eji redioaktiiki isotropes nke ayodiin
• ketoacidosis na lactic acidosis.

Na mgbakwunye, ụmụ nwanyị ekwesịghị ị theụ ọgwụ ahụ n'oge ime na lact.

Ihe omume na - ebute nsonaazụ nwere ike igosipụta onwe ya n'akụkụ akụkụ dị iche iche na sistemụ nke ahụ mmadụ - eriri afọ, metabolism, usoro akwara obi, yana akpụkpọ ahụ. Ihe mmeghachi omume kachasị njọ nke nwere ike ịme n'ihi ị theụ ọgwụ bụ:

1. Egwuregwu dị elu. Oge ụfọdụ ọgbụgbọ na-apụta n'ụdị ọrịa shuga 2. Enwere ike dochie ọgbụgbọ site na ọgbụgbọ.
2. Typedị afọ na-egbu mgbu.
3. Ntughari nke ihe otite n’ime onu.
4. Hematopoiesis na hemostasis.
5. Megaloblastic anaemia.
6. Mbelata shuga dị n'ọbara n'okpuru ọkwa a na-anabata nke ọma - hypoglycemia.
7. Ọdịdị nke adịghị ike n’anụ ahụ.
8. Rowsjọ.
9. Hypotension.
10. Ọrịa akụkụ iku ume.
11. Ọdịdị nke dermatitis ma ọ bụ ihe ọkụ ọkụ na anụahụ.

Ekwesịrị ịkpachara anya mgbe ị na-ewere Langerin na ọgwụ ndị ọzọ. Otu mbadamba osisi na cymeditine n’otu oge na-ebulite ohere nke lactic acidosis. Nchikota nke Langerin na akwara loop, nwere ike imeputa otu ihe ahu. N'okwu a, na mgbakwunye na enwere ike igosipụta lactic acidosis, enwere ike ịhụ ngosipụta nke ọdịda akụrụ.

N'iji ọgwụ ọjọọ eme ihe, ọ dị mkpa iji nyochaa arụmọrụ akụrụ dị mma ma chọpụta ego nke lactate na plasma ọbụlagodi ugboro abụọ n'afọ.

Enyere ozi banyere ọgwụ ndị e ji agwọ ọrịa shuga na vidiyo dị n'isiokwu a.

Nkọwapụta ọgwụ ọjọọ

Langerine - Nnukwu hypoglycemic onye nnọchi anya nke otu biguanides (dimethylbiguanide). Usoro nke metformin na-ejikọta ya na ikike ya iji mee ka gluconeogenesis kwụsị, yana imepụta abụba na-enweghị ihe na nsị nke abụba. Na-eme ka mmata nke ndị na-anabata ihe na insulin na itinye glucose site na sel. Metformin anaghị emetụta oke insulin n'ime ọbara, mana ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe ma na-abawanye oke nke insulin na proinsulin.

Metformin na-akpali njikọ nke glycogen site na ime ihe na glycogen synthetase. Na-eme ka ikike ibuwanye nke ndị na-ebuga glucose ụdị ọ bụla. Na-egbu oge itinye glucose umeji.

Belata ogo triglycerides, LDL, VLDL. Metformin na - eme ka akwara fibrinolytic dị n'ọbara site na - egbochi ihe mgbochi plasminogen onye na - eme ka anụ ahụ nwee ọrụ.

Mgbe ị na-ewere metformin, ịdị arọ nke onye ọrịa ahụ ọ na-adịgide ma ọ bụ na-ebelata obere oge.

Ndepụta nke analogues

Edemede na-atọ ụtọ

Etu ị ga - ahọrọ ezi aha analog
Na pharmacology, a na-ekekarị ọgwụ iji mee ka okwu na analogues. Ihe mejuputara ya bu otu uzo ma obu ozo si aru aru nke nwere aru oru aru. Site na analogs bu ọgwụ ndi nwere ihe ndi ozo di ndu, mana ndi mmadu na acho ya.

Ọdịiche dị n’etiti nje virus na nje
Ọ bụ nje virus, nje, fungi na protozoa na-ebute ọrịa ndị na-efe efe. Ọrịa na-ebute nje na nje na-abụkarị. Agbanyeghị, ịmata ihe kpatara ọrịa ahụ pụtara ịhọrọ usoro ọgwụgwọ dị mma ga-enyere aka ịnagide ọrịa ngwa ngwa na agaghị emerụ nwa ahụ.

Ihe nfụkasị bụ ihe na-akpata otutu oge
Peoplefọdụ ndị maara ọnọdụ nwatakịrị na-arịakarị ụfụ na ogologo oge. Ndị nne na nna na-akpọrọ ya gaa na nke ndị dọkịta, na-ele ule, na-a drugsụ ọgwụ ọjọọ, n'ihi ya, a na-edebanye aha nwatakịrị ahụ na dọkịta ụmụaka mgbe ọ na-arịa ọrịa. Amaghị ihe kpatara ọrịa ọrịa iku ume ugboro ugboro.

Urology: ọgwụgwọ chlamydial urethritis
Chlamydial urethritis na-ahụkarị n’omume urologist. Ọ bụ Chlamidia trachomatis nke nje intracellular, nke nwere akụrụngwa nke nje na nje, nke na-achọkarị ọgwụ mgbochi ogologo oge maka ọgwụgwọ antibacterial. O nwere ike ibute oke urera na ụmụ nwoke na ụmụ nwanyị.

Langerin - ntuziaka maka ojiji, ọnụahịa, nyocha

Peeji ahụ na-enye ozi gbasara ọgwụ Langerin - a na-enye ntuziaka na ntụgharị n'efu. Maka ozi ndị ọzọ zuru oke, biko rụtụrụ aka na nkọwapụta onye nrụpụta. Ndụmọdụ ndị dịnụ maka ọgwụ ọjọọ abụghị ihe ndabere maka ịgwọ onwe gị.

Ndị na-emepụta ihe: Zentiva a.s (Slovak Republic)

Bekee arụ ọrụ
Klas nke ọrịa

• Mellitus na-arịa insulin na-abụghị insulin

Linlọ ọgwụ na ọgwụ ọgwụ

• Akọwapụtaghị ya. Lee ntuziaka

Omume ọgwụ
Ndị na-ahụ maka ọgwụ

• Hypoglycemic synthetic na ndị ọzọ na-ejikọ ọnụ

Weputara udi nke ogwu Langerin

Mpempe akwụkwọ mkpuchi 500mgị 500, mbadamba mkpọ 10 kaadiboodu 6 ngwugwu, mbadamba 500 nke ihe nkiri na-acha odo odo, igbe mkpọ 10 ngwugwu 10 nke kaadiboodu 3, mbadamba ihe mkpuchi 500 mg, mbadamba mkpọ 10 nke kaadiboodu 9, ọgwụ, 850 mg ihe mkpuchi-acha uhie uhie, ngwugwu mkpọ 10 mkpọ kaadiboodu 6, mbadamba ihe, 850 mg filled blister pack, 850 mg film blister pack, 10 packboard kaadiboodu 3, mbadamba ihe mkpuchi fim 850 mg, pack bliri pack Mpempe 10 nke kaadiboodu 9, mbadamba ihe mkpuchi na ihe nkiri 1 g, ọnya mkpọ 10 mkpọ kaadiboodu 1, mbadamba ihe mkpuchi na ihe nkiri 1 g, ọnya na-eji mkpọ 10 kaadiboodu 3, mbadamba ihe mkpuchi na ihe nkiri 1 1, mkpọ ọnya 10 mkpọ nke kaadiboodu 9,

mbadamba nkume nke mkpuchi vidio nke 1 g, nke na-acha uhie uhie mkpọ nke kaadiboodu 6,

Mlọ ọgwụ

Na -ebelata mkpụkọ glucose (na afo efu na mgbe i richara nri) n'ọbara na ọkwa glycosylated haemoglobin, na-eme ka nnabata glucose dịkwuo elu. Na-ebelata nnabata afọ nke glucose, imepụta ya na imeju, na-eme ka insulin mara na anụ ahụ na-emetụta (glucose uptake and metabolism metabolism).

Ọ naghị agbanwe mkpụrụ ndụ insulin site na mkpụrụ ndụ beta nke agwaetiti pancreatic (ọkwa insulin tụrụ na afọ efu na nzaghachi insulin kwa ụbọchị nwere ike ibelata).

Ọ na - eme ka profaịlụ ọbara nke plasma ọbara dị na ndị ọrịa nwere ọrịa mellitus na - abụghị insulin: ọ na - ebelata ọdịnaya nke triglycerides, cholesterol na LDL (kpebisiri ike na afọ efu) na anaghị agbanwe ọkwa nke lipoproteins nke njupụta ndị ọzọ. Na-eme ka ahụ gị dị ike ma ọ bụ belata ya.

Mlọ ọgwụ

Anọrọ ngwa ngwa si na nri diges. Ihe zuru oke bioavailability (na afọ efu) bụ 50-60%. A na-enweta Cmax na plasma mgbe awa 2. A na-eri nri dị ala Cmax 40% ma na-eji nwayọ nwayọ na-ebelata nkeji 35.

Ọkpụkpụ ọgbụgba met metinin n’ọbara rute n’ime awa iri abụọ na anọ na iri anọ na anọ agafegaghị 1 /g / ml. Olu nke nkesa (maka otu ihe ruru 850 mg) bụ (654 ± 358) l. Obere ihe n’agbata protein nke plasma, nwere ike imubanye n’agbụrụ imeju, imeju na akụrụ.

Ọ na-apịpụta akụrụ (ọkachasị site na tubular secretion) anaghị agbanwe agbanwe (90% kwa ụbọchị). Renal Cl - 350-550 ml / min. T1 / 2 bụ 6.2 h (plasma) na 17.6 h (ọbara) (ihe dị iche bụ n'ihi ikike ịgbakọ mkpụrụ ndụ ọbara uhie).

N'ime ndị agadi, T1 / 2 adịla ogologo ma Cmax na-abawanye. Ọ bụrụ na arụ ọrụ ezumike ọrụ na-arụ ọrụ, T1 / 2 na-agbatịkwu ogologo na mkpochapu akwara na-ebelata.

N'oge ọgwụgwọ kwesịrị ịkwụsị inye ara.

Ihe ngbanwe

Ahụhụ hyperensitivity, ọrịa akụrụ, ma ọ bụ ọdịda akụrụngwa (ọkwa nke creatinine karịrị 0.132 mmol / L n'ime ụmụ nwoke na 0.123 mmol / L n'ime ụmụ nwanyị), oke ọgbụgba akwara, ọnọdụ yana hypoxia (gụnyere

ọrịa obi na akụkụ iku ume, oke akụkụ nke myocardial infarction, oke ụbụrụ cerebrovascular insufficiency, anemia), akpịrị ịkpọ nkụ, ọrịa na-efe efe, arụmọrụ buru ibu na mmerụ ahụ, mmanya na-egbu egbu, nnukwu ma ọ bụ metabolic acidosis, gụnyere ọrịa ketoacidosis nke ọrịa mamịrị na ma ọ bụ na-enweghị coma, akụkọ ihe mere eme nke lactic acidosis gbasoo nri nwere obere kalori (erughi 1000 kcal / ụbọchị), nyocha na-eji redioto ayodiin iodine, afọ ime, na-enye nwa ara.

Nsonaazụ

Site na eriri afọ: na mmalite nke ọgwụgwọ - anorexia, afọ ọsịsa, ọgbụgbọ, vomiting, flatulence, mgbu afọ (ibelata nri), ụtọ dị ọnụ na ọnụ (3%).

Site n'akụkụ nke sisitemu obi yana ọbara (hematopoiesis, hemostasis): n'ọnọdụ dị ụkọ - megaloblastic anaemia (nsonaazụ malabsorption nke vitamin B12 na folic acid).

Site n'akụkụ nke metabolism: hypoglycemia, n'ọnọdụ ndị a na - adịghị ahụkebe - lactic acidosis (adịghị ike, iro ụra, hypotension, bradyarrhythmia na-egbochi, nsogbu nke akụkụ okuku ume, mgbu azụ, myalgia, hypothermia).

Site na anụ ahụ: ọkụ ọkụ, ọnya afọ.

Mmekọrịta na ọgwụ ndị ọzọ

A kwụsịrị mmetụta nke metformin site na thiazide na ọgwụ ndị ọzọ, corticosteroids, phenothiazines, glucagon, homonụ thyroid, estrogens, gụnyere dịka akụkụ nke mgbochi afọ, phenytoin, acid nicotinic, sympathomimetics, ndị na-emegide calcium, isoniazid.

N'ime otu usoro n'ime ndị ọrụ afọ ofufo siri ike, nifedipine mụbara mmịpụta, Cmax (20%), AUC (9%) metformin, Tmax na T1 / 2 agbanweghị. A na - eme ka mmetụta hypoglycemic dị na insulin, ọgwụ sulfonylurea, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, AC inhibitors, ihe ndị a na - akpọ clofibrate, cyclophosphamide, beta-blockers.

Nnyocha nke otu mmekọrịta dị n'etiti ndị ọrụ afọ ofufo ahụ siri ike gosipụtara na furosemide mụbara Cmax (na 22%) na AUC (site na 15%) nke metformin (na-enweghị mgbanwe dị ukwuu na mkpochapu aha nke metformin), metformin na-ebelata Cmax (na 31%), AUC (site na 12 %) na T1 / 2 (32%) nke furosemide (na-enweghị mgbanwe dị ukwuu na mkpochapu mkpọsa nke furosemide).

Enweghị data na mmekọrịta nke metformin na furosemide na iji ogologo oge. Ọgwụ (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ebugharị ngwa ngwa na, na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye Cmax nke metformin na 60%.

Cimetidine belatara mkpochapu nke metformin, nke a na - abawanye ohere ị nwere ịmalite lactic acidosis. Na-ekwekọghi n'ihe ọ increasedụ alcoholụ na-aba n'anya (ohere dị ukwuu nke ịmalite acidosis mmiri ara ehi)

Ekwesịrị ịtụle ọrụ ntaramahụhụ, nhicha ma ọ bụ glutrị ọbara. Na nlebara anya nlebara anya ka ọ dị maka ọkwa glucose ọbara dị mkpa mgbe ị na-eji metformin yana njikọ ya na insulinlureas ma ọ bụ insulin (ihe egwu nke hypoglycemia).

Ekwesịrị ịgwọ ọgwụ ọnụ na metformin na insulin n'ụlọ ọgwụ ruo mgbe ọnye ọgwụ zuru oke. N'ime ndị ọrịa na usoro ọgwụgwọ na-aga n'ihu na metformin, ọ dị mkpa iji chọpụta ọdịnaya nke vitamin B12 otu ugboro n'afọ n'ihi mbelata nke ịmịcha ya.

Ọ dị mkpa iji chọpụta ọkwa nke lactate na plasma ọbụlagodi ugboro 2 n’afọ, yana ọdịdị nke myalgia. Site na mmụba nke ọdịnaya lactate, a na-akwụsị ọgwụ ahụ.

Ejirila ya tupu ịwa ahụ yana n'ime ụbọchị 2 mgbe emechara ha, yana n'ime ụbọchị abụọ tupu yana nyocha nyocha (intravenous urography, angiography, wdg).

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

10 PC - blisters (3) - ngwugwu nke kaadiboodu 10 pcs. - blisters (6) - ngwugwu nke kaadiboodu.

10 PC - blisters (9) - ngwugwu nke kaadiboodu.

Omume ọgwụ

Onye na-ahụ maka hypoglycemic nke sitere na ìgwè nke biguanides (dimethylbiguanide). Usoro nke metformin na-ejikọta ya na ikike ya iji mee ka gluconeogenesis kwụsị, yana imepụta abụba na-enweghị ihe na nsị nke abụba.

Metformin anaghị emetụta oke insulin n'ime ọbara, mana ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe ma na-abawanye oke nke insulin na proinsulin.

Otu njikọ dị mkpa na usoro nke metformin bụ mkpali nke glucose na - eme ka mkpụrụ ndụ mepụta ya.

Metformin na - akwalite mgbasa ọbara n'ime imeju na-emekwa ka ntụgharị glucose na glycogen gbanwee. Belata ogo triglycerides, LDL, VLDL. Metformin na - eme ka akwara fibrinolytic dị n'ọbara site na - egbochi ihe mgbochi plasminogen onye na - eme ka anụ ahụ nwee ọrụ.

1dị shuga 1 mellitus (insulin-dependance) - na ebumnuche belata mkpa insulin na igbochi oke ibu (na mgbakwunye na usoro insulin).

2dị shuga abụọ nke ọrịa shuga mellitus (nke na-abụghị insulin) ma ọ bụrụ na usoro ọgwụgwọ nri anaghị arụ ọrụ (karịchaa oke ibu).

Usoro usoro onunu ogwu

Maka ndị ọrịa anaghị anata insulin, n’ime ụbọchị atọ ndị mbụ - 500 mg ugboro atọ / ụbọchị ma ọ bụ 1 g ugboro abụọ / ụbọchị n’oge ma ọ bụ mgbe nri gasịrị. Site n'ụbọchị nke anọ ruo ụbọchị nke 14 - 1 g ugboro atọ / ụbọchị. Mgbe ụbọchị nke iri na ise gasịrị, a na-agbazi dose a na-eburu n'uche ogo glucose dị n'ọbara na mmamịrị. Usoro nlekọta ahụ bụ 100-200 mg / ụbọchị.

N'iji insulin emeghari onodu ya na oge erughi 40 nkeji / ubochi, usoro onunu ogwu nke metformin bu otu, ebe enwere ike wedata uzo insulin jiri nwayọ belata (site na nkeji 4-8 / ubochi ubochi obula). Ọ bụrụ na onye ọrịa ahụ na-enweta ihe karịrị nkeji iri anọ / ụbọchị, mgbe ahụ, ojiji nke metformin na mbelata nke insulin chọrọ nlekọta dị ukwuu ma eme ya n'ụlọ ọgwụ.

Analogs na ọnụahịa ọgwụ Langerin

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba mkpuchi

Mbadamba mbadamba dịgidere

Mbadamba mbadamba dịgidere

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba ihe mkpuchi

mbadamba ihe eji eme ihe nkiri

Mbadamba mbadamba dịgidere

Mbadamba mbadamba dịgidere

mbadamba ihe mkpuchi

Mgbakọ niile: 73 ndị dọkịta.

Ihe omuma nke ndi zaghachiri site na iche:

Mmetụta akụkụ

Site na nri digestive: enwere ike (ọ na-abụkarị na mbido ọgwụgwọ) ọgbụgbọ, ọgbụgbọ, afọ ọsịsa.

Site na usoro endocrine: hypoglycemia (tumadi mgbe ejiri ya na usoro ezighi ezi).

Site n'akụkụ nke metabolism: N'ọnọdụ ụfọdụ - lactic acidosis (chọrọ ịkwụsị ọgwụgwọ).

Site na sistemụ hemopoietic: n'ọnọdụ ụfọdụ - megaloblastic anaemia.

Ntụziaka pụrụ iche

A naghị akwado ya maka ọrịa na-efe efe, iwe ọkụ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala, na ihe ize ndụ nke akpịrị ịkpọ nkụ.

Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha.

A naghị atụ aro iji metformin na ndị ọrịa gafere afọ 60 na ndị na-arụ ọrụ anụ ahụ dị arọ, nke jikọtara ya na oke ihe ize ndụ nke ịmalite lactic acidosis.

N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ gbasara akụrụ, mkpebi nke lactate dị na plasma kwesịrị ịdịkarịa ala ugboro abụọ n’afọ, yana mpụta nke myalgia.

Enwere ike iji Metformin mee ihe na njikọta na sulfonylureas. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

A na-atụ aro iji metformin dịka akụkụ nke njikọta ọgwụ na insulin n'ụlọ ọgwụ.

Mkparịta ụka ọgwụ ọjọọ

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, yana clofibrate, cyclophosphamide, hypoglycemic mmetụta nke metformin nwere ike ịkwalite.

Site na iji GCS eme ihe n'otu oge, mgbochi nke homonụ maka nchịkwa ọnụ, adrenaline, glucagon, homonụ thyroid, ihe ndị phenothiazine, thiazide diuretics, nicotinic acid, na mbelata mmetụta hypoglycemic nke metformin ga-ekwe omume.

Iji cimetidine na-ejikọ ọnụ nwere ike ịbawanye ohere nke lactic acidosis.

37. : 2.92)
N'idebata ...

Ntuziaka LANGERIN (LANAGERIN)

Koodu ATX: A10BA02

A na-etinye Metformin na ngọngọ diges. Cmax na plasma erutela ihe dị ka awa 2 mgbe ịbasịsịrị. Ka awa 6 gachara, iwere akwara dị na eriri afọ ma kwụsịlata itinye uche metformin na plasma nke nta nke nta. Ọ na - agbakọta n'ime gland dị ya, imeju ya na akụrụ ya T1 / 2 - awa nke 1.5 --.5. Ọ bụ ya ka akpụrụ ya ga na - arụ ọrụ metalịn nwere ike ịchịkọta.

Zụta LANGERINE

Zụta na ọnụahịa dị ala:

Ndị ọbịa anyị ga-ekele gị ma ọ bụrụ na ị dee n'ime ụlọ ọgwụ dị n'ịntanetị ị hụla onyinye kacha mma.

Nkwupụta nke ndị ọbịa na ọkwa nke “ọnụahịa / arụmọrụ”: 37. : 2.92)
N'idebata ...

Ọ bụrụ n'iji ọgwụ LANZHERIN (LANAGERIN), adịla umengwụ ịhapụ nyocha gị gbasara iji ọgwụ a. Ọ dị mma ịtụle LANGERINE site opekata mpe abụọ: ọnụahịa na arụmọrụ. Will ga - enyere ndị ọzọ aka ma ọ bụrụ na i gosipụta ọrịa kpatara ọgwụ ahụ.

Langerin - nkọwa nke ọgwụ, ntuziaka maka ojiji, nyocha - Portal Medical

Dee nyocha
1 nyocha

Ndị na-emepụta ihe: Zentiva a.s (Slovak Republic)

Bekee arụ ọrụ

Klas nke ọrịa

• Mellitus na-arịa insulin na-abụghị insulin

Linlọ ọgwụ na ọgwụ ọgwụ

• Akọwapụtaghị ya. Lee ntuziaka

Omume ọgwụ

Ndị na-ahụ maka ọgwụ

• Hypoglycemic synthetic na ndị ọzọ na-ejikọ ọnụ

Jiri n’oge ime

N’ime afọ ime, ọ ga - ekwe omume ma ọ bụrụ na atụghị anya ọgwụgwọ ga - akarị n’ihe ọ bụla nwere ike ibute nwa ebu n’afọ (a mụbeghị ọmụmụ ihe zuru oke ma jiri ya na - eme ihe n’oge eji ime ya)

Usoro FDA maka ime nwa ebu n’afọ bụ B.

N'oge ọgwụgwọ kwesịrị ịkwụsị inye ara.

Mmekọrịta na ọgwụ ndị ọzọ

A kwụsịrị mmetụta nke metformin site na thiazide na ọgwụ ndị ọzọ, corticosteroids, phenothiazines, glucagon, homonụ thyroid, estrogens, gụnyere dịka akụkụ nke mgbochi afọ, phenytoin, acid nicotinic, sympathomimetics, ndị na-emegide calcium, isoniazid.

N'ime otu usoro n'ime ndị ọrụ afọ ofufo siri ike, nifedipine mụbara mmịpụta, Cmax (20%), AUC (9%) metformin, Tmax na T1 / 2 agbanweghị.

A na - eme ka mmetụta hypoglycemic dị na insulin, ọgwụ sulfonylurea, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, AC inhibitors, ihe ndị a na - akpọ clofibrate, cyclophosphamide, beta-blockers.

Nnyocha nke otu mmekọrịta dị n'etiti ndị ọrụ afọ ofufo ahụ siri ike gosipụtara na furosemide mụbara Cmax (na 22%) na AUC (site na 15%) nke metformin (na-enweghị mgbanwe dị ukwuu na mkpochapu aha nke metformin), metformin na-ebelata Cmax (na 31%), AUC (site na 12 %) na T1 / 2 (32%) nke furosemide (na-enweghị mgbanwe dị ukwuu na mkpochapu mkpọsa nke furosemide). Enweghị data na mmekọrịta nke metformin na furosemide na iji ogologo oge. Ọgwụ (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ebugharị ngwa ngwa na, na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye Cmax nke metformin na 60%. Cimetidine belatara mkpochapu nke metformin, nke a na - abawanye ohere ị nwere ịmalite lactic acidosis. Na-ekwekọghi n'ihe ọ increasedụ alcoholụ na-aba n'anya (ohere dị ukwuu nke ịmalite acidosis mmiri ara ehi)

Cakpachara anya maka ojiji

Ekwesịrị ịtụle ọrụ ntaramahụhụ, nhicha ma ọ bụ glutrị ọbara. Na nlebara anya nlebara anya ka ọ dị maka ọkwa glucose ọbara dị mkpa mgbe ị na-eji metformin yana njikọ ya na insulinlureas ma ọ bụ insulin (ihe egwu nke hypoglycemia).

Ekwesịrị ịgwọ ọgwụ ọnụ na metformin na insulin n'ụlọ ọgwụ ruo mgbe ọnye ọgwụ zuru oke. N'ime ndị ọrịa na usoro ọgwụgwọ na-aga n'ihu na metformin, ọ dị mkpa iji chọpụta ọdịnaya nke vitamin B12 otu ugboro n'afọ n'ihi mbelata nke ịmịcha ya.

Ọ dị mkpa iji chọpụta ọkwa nke lactate na plasma ọbụlagodi ugboro 2 n’afọ, yana ọdịdị nke myalgia. Site na mmụba nke ọdịnaya lactate, a na-akwụsị ọgwụ ahụ.

Ejirila ya tupu ịwa ahụ yana n'ime ụbọchị 2 mgbe emechara ha, yana n'ime ụbọchị abụọ tupu yana nyocha nyocha (intravenous urography, angiography, wdg).

Ọgwụ ndị yiri ya:

** Ntuziaka ọgwụgwọ bụ maka ebumnuche ọhụụ. Maka ozi ndị ọzọ, biko rụtụ aka na nkọwapụta onye nrụpụta.

Emela ọgwụ onwe, tupu ịmalite iji Langerin, ị kwesịrị ịkpọtụrụ dọkịta. EUROLAB abụghị onye na-ata ahụhụ nsonaazụ ya site na iji ozi ezigara na portal.

Ozi ọ bụla dị na saịtị a anaghị agbanwe ndụmọdụ nke dọkịta ma ọ nweghị ike ịbụ nkwa maka mmetụta dị mma nke ọgwụ ahụ.

Nwere mmasị na Langerin? Want chọrọ ịmatakwu nkọwa zuru ezu ma ọ bụ ịchọrọ ịhụ dọkịta? Ka ịchọrọ nyocha? Nwere ike gi na dọkịta gharia - ụlọ ọgwụ Euroụlọ nyocha mgbe niile n’ozi gị! Ndị dọkịta kachasị mma ga-enyocha gị, nye ndụmọdụ, nye enyemaka dị mkpa ma mee nchoputa. I nwekwara ike kpọọ dọkịta n'ụlọ. Thelọ ọgwụ Euroụlọ nyocha gheghe gi oghe.

** Ntị! Ihe omuma a gosiputara n’ozi ogwu a bu ndi okacha amara nke aru ike ya abughi ihe mgbakwasị aro maka ogwu eji aka ya. Ekwuputara nkọwa nke ọgwụ Langerin maka nyocha ma ebughị n'uche ịkọ ọgwụ maka enweghị nnabata dọkịta. Ndị ọrịa chọrọ ndụmọdụ ọkachamara!

Ime na lactation

Contraindicated na ime na lactation.

Jiri maka ọrụ imeju na-arụ ọrụ

Contraindicated n'ime ọrụ imeju na-arụ ọrụ nke ukwuu.

Jiri maka ọrụ ezighi ezi na-arụ ọrụ

Contraindicated na oke gbasara akụrụ.

Jiri na agadi

A naghị akwado Metformin maka ndị ọrịa karịrị afọ 60, nke a na-ejikọta ya na oke ihe ize ndụ nke lactic acidosis.

Ntụziaka pụrụ iche

A naghị akwado ya maka ọrịa na-efe efe, iwe ọkụ nke ọrịa na-efe efe na mkpali, mmerụ ahụ, ọrịa ịwa ahụ na-adịghị ala, na ihe ize ndụ nke akpịrị ịkpọ nkụ.

Ejila ya n’ihu ịwa ahụ yana n’ime ụbọchị 2 mgbe emechara ha.

A naghị atụ aro iji metformin na ndị ọrịa gafere afọ 60 na ndị na-arụ ọrụ anụ ahụ dị arọ, nke jikọtara ya na oke ihe ize ndụ nke ịmalite lactic acidosis.

N'oge ọgwụgwọ, ọ dị mkpa iji nyochaa ọrụ gbasara akụrụ, mkpebi nke lactate dị na plasma kwesịrị ịdịkarịa ala ugboro abụọ n’afọ, yana mpụta nke myalgia.

Enwere ike iji Metformin mee ihe na njikọta na sulfonylureas. N'okwu a, ọ dị mkpa iji nlezianya nyochaa ọkwa nke glucose ọbara.

A na-atụ aro iji metformin dịka akụkụ nke njikọta ọgwụ na insulin n'ụlọ ọgwụ.

Mkparịta ụka ọgwụ ọjọọ

Iji otu ihe eji eme ihe na usoro sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, yana clofibrate, cyclophosphamide, hypoglycemic mmetụta nke metformin nwere ike ịkwalite.

Site na iji GCS eme ihe n'otu oge, mgbochi nke homonụ maka nchịkwa ọnụ, adrenaline, glucagon, homonụ thyroid, ihe ndị phenothiazine, thiazide diuretics, nicotinic acid, na mbelata mmetụta hypoglycemic nke metformin ga-ekwe omume.

Iji cimetidine na-ejikọ ọnụ nwere ike ịbawanye ohere nke lactic acidosis.

37. : 2.92)
N'idebata ...

Ntuziaka LANGERIN (LANAGERIN)

Koodu ATX: A10BA02

A na-etinye Metformin na ngọngọ diges. Cmax na plasma erutela ihe dị ka awa 2 mgbe ịbasịsịrị. Ka awa 6 gachara, iwere akwara dị na eriri afọ ma kwụsịlata itinye uche metformin na plasma nke nta nke nta. Ọ na - agbakọta n'ime gland dị ya, imeju ya na akụrụ ya T1 / 2 - awa nke 1.5 --.5. Ọ bụ ya ka akpụrụ ya ga na - arụ ọrụ metalịn nwere ike ịchịkọta.

Ntụziaka maka ojiji

Leasedị ntọhapụ, ihe mejupụtara na nkwakọ

10 PC - blisters (3) - ngwugwu nke kaadiboodu 10 pcs. - blisters (6) - ngwugwu nke kaadiboodu 10 pcs. - blisters (9) - ngwugwu nke kaadiboodu.

Mbadamba ihe eji eme ihe nkiri, 850 mg: 30, 60 ma ọ bụ 90 PC. - LSR-003625/10, 04.30.10

Maka ndị ọrịa na-anabataghị insulin, n’ụbọchị atọ mbụ - 500 mg ugboro atọ n’ụbọchị. ma ọ bụ 1 g ugboro abụọ n'ụbọchị. n'oge ma ọ bụ mgbe nri gasịrị. Site n’ụbọchị nke anọ ruo n’ụbọchị nke iri na anọ - 1 g ugboro atọ n’ụbọchị. Mgbe ụbọchị nke iri na ise gasịrị, a na-agbazi dose a na-eburu n'uche ogo glucose dị n'ọbara na mmamịrị. Usoro nlekọta ahụ bụ 100-200 mg / ụbọchị.

Site n'iji insulin emeghari oge n'ime onwa na erughi nkeji iri / ubochi. usoro usoro usoro ọgwụgwọ nke metformin bụ otu, ebe enwere ike belata ntụtụ nke insulin (site na nkeji 4-8 / ụbọchị ọ bụla ọzọ). Ọ bụrụ na onye ọrịa ahụ na-enweta ihe karịrị nkeji iri anọ / ụbọchị, mgbe ahụ, ojiji nke metformin na mbelata nke insulin chọrọ nlekọta dị ukwuu ma eme ya n'ụlọ ọgwụ.

Ime na lactation

Contraindicated na ime na lactation.

Zụta LANGERINE

Zụta na ọnụahịa dị ala:

Ndị ọbịa anyị ga-ekele gị ma ọ bụrụ na ị dee n'ime ụlọ ọgwụ dị n'ịntanetị ị hụla onyinye kacha mma.

Nkwupụta nke ndị ọbịa na ọkwa nke “ọnụahịa / arụmọrụ”: 37. : 2.92)
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Ọ bụrụ n'iji ọgwụ LANZHERIN (LANAGERIN), adịla umengwụ ịhapụ nyocha gị gbasara iji ọgwụ a. Ọ dị mma ịtụle LANGERINE site opekata mpe abụọ: ọnụahịa na arụmọrụ. Will ga - enyere ndị ọzọ aka ma ọ bụrụ na i gosipụta ọrịa kpatara ọgwụ ahụ.

Langerin: nyocha banyere ọgwụ, ọnụahịa, ntuziaka

Langerin bụ otu n’ime ọtụtụ ọgwụ ọgwụ eji eme ọgwụgwọ maka usoro a na-akpọ ọrịa mellitus na-abụghị insulin. Ọgwụ bụ akụkụ nke ìgwè ọgwụ dị na biguanide, isi ihe dị na ya bụ ibelata mkpa maka mmepụta insulin.

Ọnụahịa nke Langerin dị na ụlọ ahịa ọgwụ, dabere na usoro ịchọrọ, nwere ike ịdị site na otu narị ruo narị atọ rubles.

Langerin bụ ọgwụ mbadamba ọgwụ nke a na-eji eme ihe n’ọrịa dị mgbagwoju anya nke ọrịa shuga. Akụkụ bụ isi ya bụ metformin umi. Ọgwụ bụ otu n'ime ọgwụ ndị na-ebelata shuga, a na-ejikwa ya eme ihe iji mee ka ọ̀tụ̀tụ̀ shuga dị n'ọbara dị na ndị ọrịa mamịrị.

Otu n'ime ọgwụ ndị dị otú ahụ ga-ekwe omume bụ nchịkwa ya ma ọ bụrụ na enweghi ike nke mbadamba ọrụ ndị mbụ ejirila na usoro sulfonylurea. Na mgbakwunye, oke ibu bụ nsogbu concoitant maka mmadụ niile nwere ọrịa shuga.

Ọ bụ ya mere, Langerin na-enye ohere ọ bụghị naanị iwetulata shuga dị ala, kama ọ na-enyekwa aka n’ibelata ịdị arọ nke onye ọrịa.

Ngwongwo ọgwụ na ihe ngosi maka ojiji

Usoro ihe omume nke akụkụ ahụ dị mkpa nke ọgwụ ahụ jikọtara ya na ikike ya ịkwụsị mmechi nke gluconeogenesis, yana usoro nke njikọta abụba n'efu na oxidation abụba n'efu.

Onye na-anọchite klas biguanide anaghị emetụta oke insulin wepụtara na ọbara, mana ọ na-agbanwe ọgwụ ọgwụ ya site na ibelata ogo insulin na-ejedebe na ịba ụba nke insulin na proinsulin.

Isi ihe dị mkpa na usoro nke mbadamba ihe ndị dị otú a bụ mkpali nke glucose na-eme n’ihu site na mkpụrụ ndụ akwara.

Isi ihe na-egosi maka iji ọgwụ bụ mmepe nke ọrịa shuga na-akpata insulin na mmadụ, ọkachasị enweghị ike nke nri sochiri.

Njirimara ọgwụ ọgwụ dị na Langerin gụnyere:

• na -ewelata ego nke gemoclobinꓼ glycated
• na - egbochi insulin na - egbochi sel nke ọgwụ na insulin homonụ
• ọfụma na-emetụta oke iwu nke profaịlụ akwara nke plasmaꓼ ọbara
• belata cholesterolꓼ nke ojoo

Na mgbakwunye, iji ọgwụ ahụ eme ihe nwere ike ịbelata oke ahụ.

Ntuziaka maka mbadamba mbadamba

Ọgwụ Langerin dị n'ụdị nke mbadamba mkpuchi.

Mbadamba mbadamba ndị ahụ na akpa rọba, nke a na-eji ihe mkpuchi nke aluminom ekpuchi.

A na-etinye akwa n'ime igbe kaadi na ntuziaka maka ojiji nke ọgwụ.

Dabere n’usoro ọgwụ ịchọrọ iji mee ihe, a pụrụ iji ọgwụ were zụta ọgwụ a:

1. 500 milligrams.
2. Milligrams 850.
3. Otu gram nke ihe na-arụ ọrụ.

Ofzọ isi were mbadamba nkume ahụ bụ okwu ọnụ, n'oge nri ma ọ bụ mgbe ọ gachara. Dọkịta na-aga ya depụtara usoro ịgwọ ọrịa maka onye ọrịa ọ bụla n'otu n'otu dabere ogo ọrịa ahụ. Ọzọkwa, ọkachamara n’ihe banyere ọgwụ na-ekpebi ọnụọgụ ọgwụ ole n’otu ọgwụ n’ụbọchị.

Ntụziaka Langerin maka iji mee ihe na-atụ aro ịmalite usoro ọgwụgwọ ọgwụgwọ site na iji obere nke 500 mg nke ọgwụ na-arụ ọrụ. Ọnụ ọgụgụ nke ọgwụ mgbe ụbọchị nwere ike ịbụ otu ruo atọ.

Nke nta nke nta, usoro onodi ogwu nwere ike ibuwanye 850 mg nke ihe eji arụ ọrụ ụbọchị dum (otu ugboro ugboro abụọ n'ụbọchị).

Dọkịta na-aga ahụ na-enyocha ọnọdụ onye ọrịa ma ọ bụghị ihe karịrị otu ugboro n'izu, na-edozigharị ọnụọgụ ọgwụ agbagoro elu.

Edekwa ọgwụ a maka ịgwọ ọrịa ahụ na ụmụaka karịa afọ iri. Monotherapy kwesịrị ịmalite site na iji ọgwụ nke 500 mg nke ihe ahụ na-arụ ọrụ otu ugboro ma ọ bụ ugboro abụọ n'ụbọchị. Mgbe oge ụfọdụ gasịrị, a na-ekwe ka mmụba nke ọgwụ ahụ nwayọ nwayọ, ma ọ dịghị karịa gram abụọ kwa ụbọchị, kewara abụọ ma ọ bụ atọ.

Dị ka ọ na-adị, mgbanwe n’usoro nke ọgwụ a na-apụta mgbe ụbọchị iri ruo ụbọchị iri na ise dabere na nsonaazụ nyocha ọbara maka ọkwa glucose.

N'ọnọdụ ụfọdụ, ịkwadebe mbadamba ụrọ bụ akụkụ nke ọgwụ ngwakọta na inje insulin.

Okwesiri iburu n'uche na a na-ahụta ochichi nke Langerin nwere insulin, ihe ndị na-eme ka sulfonylurea, acarbose, ma ọ bụ ndị na-egbochi ACE iji mee ka mmetụta hypoglycemic nke ọgwụ ahụ dịkwuo elu.

N'ọnọdụ ụfọdụ, dibịa na-aga ahụ nwere ike iji mbadamba ihe mebere ụdị dochie iji Langerin. Taa, enwere ọtụtụ ọgwụ, ihe bụ isi ọrụ ya bụ metformin.

Ọnụahịa ọgwụ analog nwere ike ịdị iche iche, dabere na ụlọ ọrụ ndị na-emepụta ọgwụ.

Kedu ihe bụ contraindications maka ojiji?

Usoro ọgwụgwọ ahọpụtara n'ụzọ na-ezighi ezi ma ọ bụ na-agbasoghị ndụmọdụ nke dibịa na-aga nwere ike ịkpasu ọdịdị nke mmeghachi omume ọjọọ mgbe ị na-a theụ ọgwụ ahụ.

Na mgbakwunye, enwere oge enwere iji iwu ọgwụ megide metformin amachibidoro.

Ntuziaka maka iji ọgwụ ahụ na-egosi ndepụta nke contraindications kachasị.

Ihe ndi ozo banyere ojiji nke mbadamba Langerin bu ihe ndi a:

• oke nrụrụ imeju ma ọ bụ ọrụ akụrụ, ụkọ ha
• ahoụrụma, gụnyere n'ụdị na-adịghị ala ala
• obi ma ọ bụ iku ume ọdịda
• nnukwu myocardial infarctionꓼ
• Ọnọdụ akpịrị na-arịa ọrịa shuga ma ọ bụ nna nna
• mmepe nke ọrịa mamịrị ụkwụ na-arịa ọrịa shuga
• na ọnụnọ nke nnabata nke mmadụ na metformin yana mmepe nke mmeghachi ahụ nfụkasị ahụ
• ọnụnọ nke ọrịa na-efe efeꓼ
• na-ebu ọnụ na-arịa ọrịa shuga ma ọ bụ na-eso nri nri nke nri ya kwa ụbọchị anaghị aga otu puku kilocaloriesꓼ
• tupu yana mgbe a gbasịrị yaꓼ
• ya na mmerụ ahụ buru ibu na nso nso a
• tupu na mgbe nchọpụta ọrịa na-eji redioaktiiki isotropes nke ayodiin
• ketoacidosis na lactic acidosis.

Na mgbakwunye, ụmụ nwanyị ekwesịghị ị theụ ọgwụ ahụ n'oge ime na lact.

Ihe omume na - ebute nsonaazụ nwere ike igosipụta onwe ya n'akụkụ akụkụ dị iche iche na sistemụ nke ahụ mmadụ - eriri afọ, metabolism, usoro akwara obi, yana akpụkpọ ahụ. Ihe mmeghachi omume kachasị njọ nke nwere ike ịme n'ihi ị theụ ọgwụ bụ:

1. Egwuregwu dị elu. Oge ụfọdụ ọgbụgbọ na-apụta n'ụdị ọrịa shuga 2. Enwere ike dochie ọgbụgbọ site na ọgbụgbọ.
2. Typedị afọ na-egbu mgbu.
3. Ntughari nke ihe otite n’ime onu.
4. Hematopoiesis na hemostasis.
5. Megaloblastic anaemia.
6. Mbelata shuga dị n'ọbara n'okpuru ọkwa a na-anabata nke ọma - hypoglycemia.
7. Ọdịdị nke adịghị ike n’anụ ahụ.
8. Rowsjọ.
9. Hypotension.
10. Ọrịa akụkụ iku ume.
11. Ọdịdị nke dermatitis ma ọ bụ ihe ọkụ ọkụ na anụahụ.

Ekwesịrị ịkpachara anya mgbe ị na-ewere Langerin na ọgwụ ndị ọzọ. Otu mbadamba osisi na cymeditine n’otu oge na-ebulite ohere nke lactic acidosis. Nchikota nke Langerin na akwara loop, nwere ike imeputa otu ihe ahu. N'okwu a, na mgbakwunye na enwere ike igosipụta lactic acidosis, enwere ike ịhụ ngosipụta nke ọdịda akụrụ.

N'iji ọgwụ ọjọọ eme ihe, ọ dị mkpa iji nyochaa arụmọrụ akụrụ dị mma ma chọpụta ego nke lactate na plasma ọbụlagodi ugboro abụọ n'afọ.

Enyere ozi banyere ọgwụ ndị e ji agwọ ọrịa shuga na vidiyo dị n'isiokwu a.

Gosiputa shuga gi ma obu hota okike maka ntuziaka.

Langerin - nkọwa nke ọgwụ, ntuziaka maka ojiji, nyocha - Portal Medical

Dee nyocha
1 nyocha

Ndị na-emepụta ihe: Zentiva a.s (Slovak Republic)

Bekee arụ ọrụ

Klas nke ọrịa

• Mellitus na-arịa insulin na-abụghị insulin

Linlọ ọgwụ na ọgwụ ọgwụ

• Akọwapụtaghị ya. Lee ntuziaka

Omume ọgwụ

Ndị na-ahụ maka ọgwụ

• Hypoglycemic synthetic na ndị ọzọ na-ejikọ ọnụ

Mbadamba ụbụrụ Langerin (Lanagerin)

Ntuziaka maka ọgwụ eji ọgwụ eme ihe

Ihe ngosi maka ojiji

Elldị nke abụọ nke ọrịa shuga mellitus (karịsịa n'ihe metụtara oke ibu) yana enweghị ike nke nrụzi hyperglycemia na usoro nri, gụnyere yana nkwadebe nke sulfonylurea.

Mpempe mwepụta

Mpempe akwụkwọ mkpuchi 500mgị 500, mbadamba mkpọ 10 kaadiboodu 6 ngwugwu, mbadamba 500 nke ihe nkiri na-acha odo odo, igbe mkpọ 10 ngwugwu 10 nke kaadiboodu 3, mbadamba ihe mkpuchi 500 mg, mbadamba mkpọ 10 nke kaadiboodu 9, ọgwụ, 850 mg ihe mkpuchi-acha uhie uhie, ngwugwu mkpọ 10 mkpọ kaadiboodu 6, mbadamba ihe, 850 mg filled blister pack, 850 mg film blister pack, 10 packboard kaadiboodu 3, mbadamba ihe mkpuchi fim 850 mg, pack bliri pack Mpempe 10 nke kaadiboodu 9, mbadamba ihe mkpuchi na ihe nkiri 1 g, ọnya mkpọ 10 mkpọ kaadiboodu 1, mbadamba ihe mkpuchi na ihe nkiri 1 g, ọnya na-eji mkpọ 10 kaadiboodu 3, mbadamba ihe mkpuchi na ihe nkiri 1 1, mkpọ ọnya 10 mkpọ nke kaadiboodu 9,

mbadamba nkume nke mkpuchi vidio nke 1 g, nke na-acha uhie uhie mkpọ nke kaadiboodu 6,

Jiri n’oge ime

N’ime afọ ime, ọ ga - ekwe omume ma ọ bụrụ na atụghị anya ọgwụgwọ ga - akarị n’ihe ọ bụla nwere ike ibute nwa ebu n’afọ (a mụbeghị ọmụmụ ihe zuru oke ma jiri ya na - eme ihe n’oge eji ime ya)

Usoro FDA maka ime nwa ebu n’afọ bụ B.

N'oge ọgwụgwọ kwesịrị ịkwụsị inye ara.

Mmekọrịta na ọgwụ ndị ọzọ

A kwụsịrị mmetụta nke metformin site na thiazide na ọgwụ ndị ọzọ, corticosteroids, phenothiazines, glucagon, homonụ thyroid, estrogens, gụnyere dịka akụkụ nke mgbochi afọ, phenytoin, acid nicotinic, sympathomimetics, ndị na-emegide calcium, isoniazid.

N'ime otu usoro n'ime ndị ọrụ afọ ofufo siri ike, nifedipine mụbara mmịpụta, Cmax (20%), AUC (9%) metformin, Tmax na T1 / 2 agbanweghị.

A na - eme ka mmetụta hypoglycemic dị na insulin, ọgwụ sulfonylurea, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, AC inhibitors, ihe ndị a na - akpọ clofibrate, cyclophosphamide, beta-blockers.

Nnyocha nke otu mmekọrịta dị n'etiti ndị ọrụ afọ ofufo ahụ siri ike gosipụtara na furosemide mụbara Cmax (na 22%) na AUC (site na 15%) nke metformin (na-enweghị mgbanwe dị ukwuu na mkpochapu aha nke metformin), metformin na-ebelata Cmax (na 31%), AUC (site na 12 %) na T1 / 2 (32%) nke furosemide (na-enweghị mgbanwe dị ukwuu na mkpochapu mkpọsa nke furosemide). Enweghị data na mmekọrịta nke metformin na furosemide na iji ogologo oge. Ọgwụ (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren na vancomycin) zoro ezo na tubules na-asọrịta mpi maka usoro ebugharị ngwa ngwa na, na usoro ọgwụgwọ ogologo oge, nwere ike ịbawanye Cmax nke metformin na 60%. Cimetidine belatara mkpochapu nke metformin, nke a na - abawanye ohere ị nwere ịmalite lactic acidosis. Na-ekwekọghi n'ihe ọ increasedụ alcoholụ na-aba n'anya (ohere dị ukwuu nke ịmalite acidosis mmiri ara ehi)

Cakpachara anya maka ojiji

Ekwesịrị ịtụle ọrụ ntaramahụhụ, nhicha ma ọ bụ glutrị ọbara. Na nlebara anya nlebara anya ka ọ dị maka ọkwa glucose ọbara dị mkpa mgbe ị na-eji metformin yana njikọ ya na insulinlureas ma ọ bụ insulin (ihe egwu nke hypoglycemia).

Ekwesịrị ịgwọ ọgwụ ọnụ na metformin na insulin n'ụlọ ọgwụ ruo mgbe ọnye ọgwụ zuru oke.N'ime ndị ọrịa na usoro ọgwụgwọ na-aga n'ihu na metformin, ọ dị mkpa iji chọpụta ọdịnaya nke vitamin B12 otu ugboro n'afọ n'ihi mbelata nke ịmịcha ya.

Ọ dị mkpa iji chọpụta ọkwa nke lactate na plasma ọbụlagodi ugboro 2 n’afọ, yana ọdịdị nke myalgia. Site na mmụba nke ọdịnaya lactate, a na-akwụsị ọgwụ ahụ.

Ejirila ya tupu ịwa ahụ yana n'ime ụbọchị 2 mgbe emechara ha, yana n'ime ụbọchị abụọ tupu yana nyocha nyocha (intravenous urography, angiography, wdg).

Ndị so na ATX nhazi ọkwa:

Ọkpụkpụ nri na metabolism

Ọgwụ A10 maka ọrịa shuga

A10B Oral hypoglycemic ọgwụ

Ọgwụ ndị yiri ya:

** Ntuziaka ọgwụgwọ bụ maka ebumnuche ọhụụ. Maka ozi ndị ọzọ, biko rụtụ aka na nkọwapụta onye nrụpụta.

Emela ọgwụ onwe, tupu ịmalite iji Langerin, ị kwesịrị ịkpọtụrụ dọkịta. EUROLAB abụghị onye na-ata ahụhụ nsonaazụ ya site na iji ozi ezigara na portal.

Ozi ọ bụla dị na saịtị a anaghị agbanwe ndụmọdụ nke dọkịta ma ọ nweghị ike ịbụ nkwa maka mmetụta dị mma nke ọgwụ ahụ.

Nwere mmasị na Langerin? Want chọrọ ịmatakwu nkọwa zuru ezu ma ọ bụ ịchọrọ ịhụ dọkịta? Ka ịchọrọ nyocha? Nwere ike gi na dọkịta gharia - ụlọ ọgwụ Euroụlọ nyocha mgbe niile n’ozi gị! Ndị dọkịta kachasị mma ga-enyocha gị, nye ndụmọdụ, nye enyemaka dị mkpa ma mee nchoputa. I nwekwara ike kpọọ dọkịta n'ụlọ. Thelọ ọgwụ Euroụlọ nyocha gheghe gi oghe.

** Ntị! Ihe omuma a gosiputara n’ozi ogwu a bu ndi okacha amara nke aru ike ya abughi ihe mgbakwasị aro maka ogwu eji aka ya. Ekwuputara nkọwa nke ọgwụ Langerin maka nyocha ma ebughị n'uche ịkọ ọgwụ maka enweghị nnabata dọkịta. Ndị ọrịa chọrọ ndụmọdụ ọkachamara!

Ihe eji arụ ọrụ

- metformin hydrochloride (metformin)

Ime na lactation

Emebeghị nnyocha omumu ihe doro anya na nke ekwesiri idi nma banyere metformin n’oge di ime. Ojiji n’oge ime ga-ekwe omume n’ihe gbasara ọnọdụ mberede, mgbe uru elere anya na usoro ọgwụgwọ maka nne ji karịa nwa nwere ike ibute nwa ebu n’afọ. Metformin na-agafe oghere mgbochi.

A na-ahụkarị Metformin na mmiri ara ehi, ebe ịta metformin na mmiri ara nwere ike ịbụ 1/3 nke ịta na plasma nne. Achọpụtaghị nsonaazụ n'akụkụ ụmụ amụrụ ọhụrụ n’oge a na-enye nwa ara ma na-ewere metformin

Agbanyeghị, n'ihi oke data, ole ka akwadoro ka a na-enye ara.

Ekwesịrị ime mkpebi ịkwụsị inye ara, na-eburu n'uche uru ị breastụ ara na ohere nke nsonaazụ nwata a.

Ọmụmụ preclinical gosipụtara na metformin enweghị mmetụta teratogenic na usoro onyonyo nke ji okpukpu abụọ dị elu karịa usoro ọgwụgwọ eji eme mmadụ. Metformin enweghị ikike nke mutagen, ọ naghị emetụta ọmụmụ ọmụmụ.