Emoxibel - ntuziaka gọọmentị maka ojiji

Usoro onunu ogwu nke Emoxibel weputara:

• ihe ngwọta maka infusion: na-enweghị ụcha, na-enweghị atụ (na karama mmiri nke 100 ml, na igbe kaadiboodu 1 karama),
• ihe omuma maka intravenous (i / v) na nchịkwa intramuscular (m / m): ụcha na-acha uhie uhie ma ọ bụ enweghị isi, na-apụta ìhè (na 10 ml vials, na ampoules 5 ml, na blisters nke 5 ampoules, na ngwungwu 1 ma ọ bụ 2) nkwakọ ma ọ bụ karama 1),
• anya na-ada: na-eji odo na-acha odo odo ma ọ bụ nke enweghị agba, na-ahụ ihe (na karama 5 ml, na karama 1 na karama),
• ịgba ntụtụ: na-enweghị ụcha, na-acha ọcha (na ampoules nke 1 ml, na ngwugwu ọnya 5 ampoules, na mkpọ kaadi nke 10 ampoules 10 ma ọ bụ ngwugwu 1 ma ọ bụ ngwugwu ampoule na kit).

Ngwakọta nke 1 ml Emoxibel Infusion Solution:

• ihe na-arụ ọrụ: methylethylpyridinol hydrochloride (emoxypine) - 0.005 g,
• ihe inyeaka: mmiri maka inpa, chloride sodium.

Ngwakọta nke 1 ml nke ihe ngwọta maka iv na nchịkwa intramuscular nke Emoxibel:

• ihe na-arụ ọrụ: methylethylpyridinol hydrochloride (emoxypine) - 0.03 g,
• ihe inyeaka: mmiri maka injection, sodium hydrogen phosphate dodecahydrate, sodium sulfite.

Ihe mejupụtara nke 1 ml tụlee nke Ophhalmic Emoxibel:

• ihe na-arụ ọrụ: methylethylpyridinol hydrochloride (emoxypine) - 0.01 g,
• ihe inyeaka: mmiri maka injection - ruo 1 ml, sodium hydrogen phosphate dodecahydrate - 0.007 5 g, potassium dihydrogen phosphate - 0.006 2 g, sodium benzoate - 0.002 g, sodium sulfite - 0.003 g.

Ngwakọta nke 1 ml Emoxibel Injection:

• ihe na-arụ ọrụ: methylethylpyridinol hydrochloride (emoxypine) - 0.01 g,
• ihe inyeaka: mmiri maka injection - ruo 1 ml, hydrochloric acid solution (0.1 M) - 0.02 ml.

Mlọ ọgwụ

Ekele maka ihe arụ ọrụ nke bụ Emoxibel, ọ na - eme ihe ndị a:

• na-emetụta usoro coagulation ọbara nke ọma: ọ na-agbatịkwu oge ịmịnye ọbara, na-ebelata ntụpọ coagulation n'ozuzu ya, na-egbochi nchịkọta platelet,
• na-eme ka iguzogide sel ọbara ọbara na hemolysis na usoro arụmọrụ, na-eme ka mkpụrụ ndụ akwara nke ọbara na sel ọbara ọbara dịrị.
• ọ na - eme microcirculation,
• na-abawanye ọrụ nke enzymes antioxidant, na-egbochi mgbochi ụfụfụ n'efu nke lipids nke ncheta ndu.
• nwere mmetụta antitoxic na angioprotective, na-emezi cytochrome P₄₅₀,
• na-eme ka usoro ihe ọkụkụ dịkwuo elu n'ọnọdụ ndị jọgburu onwe ya, yana hypoxia na ụba peroxidation ịba ụba,
• na-eme ka nguzogide ụbụrụ dịrị na ischemia na hypoxia,
• ya na ọrịa ụbụrụ na ọbara ọgbụgba nke ọrịa ụbụrụ na-eme ka ọrụ mnemonic dịkwuo mma, na-eme ka mweghachi nke ọrụ ụbụrụ na-arụ ọrụ, na-enye aka na mgbazi nke ahịhịa ndụ,
• na-ebelata triglyceride synthesis, nwere akụ na-ebelata
• na-ebelata ischemic mbibi nke myocardium, dilates arịa akwara ọbara,
• ya na myocardial infarction, ọ na-enye aka na nhazi nke metabolism nke myocardial, na-eme ka usoro mmegwara kwụsị, na -ego ogo ngbado nke necrosis,
• site na mbenweta nnukwu ọrịa obi na-emetụta nke ọma gbasara ọrịa myocardial infarction,
• na okirikiri ọdịda na-enye usoro nke usoro redox.

Mlọ ọgwụ

Njirimara nke methylethylpyridinol hydrochloride (emoxypine):

• mmado: ya na ihe mmeghe nwere oge mkpochapu ọkara (T_½ dị minit 18, nke na-egosi oke mkpochapu ọbara ọbara), mkpochapu oge niile bụ 0.041 min, mkpochapu nke Cl bụ 214.8 ml kwa 1 min,
• nkesa: oke ihe ekesara - 5,2 l, na - abanye ngwa ngwa na akwara nke mmadụ, ebe edobere ma mezie ya.
• metabolism: o nwere metabolites 5 nke ihe conjugated na dealkylated nke ntụgharị ya na-anọchite anya ya, akụrụ na-ahụpụta akụrụ, 2-ethyl-6-methyl-3-hydroxypyridine phosphate dị n'ọtụtụ dị ukwuu na imeju,
• mwepu: ọnọdụ a na - ahụ maka ọrịa belata ọnụego nke mwepụ ya, nke na - eme ka bioavailability ya dịkwuo elu, ma na - emekwa ka oge obibi ya dị n'ọbara (enwere ike ijikọ ya na nlọghachi ya site na ebusa, gụnyere site na isyomic myocardium).

Aclọ ọgwụ ọgwụ Emoxibel nọ n'ọnọdụ ọrịa na-agbanwe (dịka ọmụmaatụ, ya na mgbaze ọgbụgba).

Ngwọta maka infusion, ihe ngwọta maka nchịkwa iv na / m

• oge ọrịa na ọrịa oge ọnya ọrịa traumatic, na-arụ ọrụ maka intracerebral, subdural na hematomas jikọtara ya na mmerụ ụbụrụ, isi isi na mmerụ ụbụrụ, ụbụrụ na-adịghị ala ala, ọrịa ụbụrụ nke na-adịghị ala ala, ọnụnọ ọbara ọgbụgba, ọrịa strok. n'ime ọdọ mmiri nke akwara carotid na akwara vertebrobasilar (eji ya na akwara akwara)
• angina pectoris ejighi ike, mgbochi nke ọrịa syerfusion syndrome, nnukwu myocardial infarction (eji ya na obi).

Ngwọta maka ntụtụ

• ọkụ, mmerụ ahụ, ọrịa degenerative nke cornea,
• iwepu akwara obi nke anya ya na glaucoma na oge izipu ihe,
• ụdị akpukpọ nke ajọ akụkụ,
• mgbagwoju anya nke myopathy
• chorioretinal dystrophy (etiti na mpaghara),
• ọrịa animeretinopathy, gụnyere ọrịa shuga,
• ọbara mgbochi intraocular na subconjunctival nke usoro dị iche iche,
• thrombosis nke isi akwara nke retina na alaka ya,
• mgbochi na ọgwụgwọ nke ọnya anya nwere oke ọkụ (ọkụ laser n'oge ọnụnọ laser, ụzarị anyanwụ).

Ihe ngbanwe

• n'okpuru afọ 18
• ịtụrụ ime (belụsọ ya gbaa ya agba)
• lactation (belụsọ maka ịgba ntụtụ)
• mmadụ inabata ya na ọgwụ ndị ahụ.

Ikwu (oria / ọnọdụ ọnụnọ nke Emoxibel chọrọ nlezianya):

• ihe ngwọta maka nchịkwa intravenous na intramuscular: ọnụnọ nke ihe mgbaàmà nke ọbara ọgbụgba dị ukwuu, arụ ọrụ ịwa ahụ, ụbụrụ na-adịghị mma.
• injection: afọ ime, lactation.

Ngwọta maka nchịkwa intram

Emoxibel na-achịkwa na / n'ime ma ọ bụ / m. Tupu nchịkwa iv, a na-agwakọta ihe ngwọta na 200 ml nke ihe dextrose 5% ma ọ bụ 0.9% sodium chloride.

Settọ usoro ọgwụ na oge ọgwụgwọ ka edobere n’otu n’otu.

• akwara, neurosurgery: nsị shuga nke 0.01 g kwa 1 n'arọ nke ịdị arọ ya kwa ụbọchị na ọnụọgụ 20-30 na 1 min maka ụbọchị 10-12, mgbe ahụ a na-ebufe onye ọrịa ahụ na ntụtụ intramuscular nke 0.06-0 , 3 g 2-3 ugboro n'ụbọchị maka ụbọchị 20,
• kadiology: iv drip 0.6-0.9 g 1-3 ugboro kwa ụbọchị na ọnụego nke 20-40 dara na 1 min maka 5-15 ụbọchị na ịnyefe onye ọrịa na nchịkwa 0.06-0 , 3 g nke ogwu 2-3 ugboro n'ụbọchị maka ụbọchị 10-30.

Ntụziaka pụrụ iche

A na-eme usoro ọgwụgwọ Emoxibel n'okpuru nchịkwa ọbara na ọbara mgbali mgbe niile.

Ngwọta maka infusion ekwesịghị agwakọta ya na ọgwụ ndị ọzọ.

Tupu instillation nke anya na-agbada, a ga-ewepụ mịkpọ kọntaktị dị nro. Mgbe minit 20 (ọ bụghị na mbụ), enwere ike iyi akwa ahụ. N'ihe banyere usoro ọgwụgwọ jikọtara anya na anya mmiri ndị ọzọ, Emoxibel etinyere na nke ikpeazụ, nkeji iri na ise (ọ bụghị na mbụ) mgbe ị completeụchara ọgwụ ọgwụ gara aga.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Na mbido ojiji nke ihe ngwọta maka infusion, yana ndị ọrịa na-achọpụta ura ụra ma ọ bụ mbelata ọbara mgbali mgbe ejiri ihe ngwọta maka nchịkwa iv na / m ma ọ bụ ntụtụ, ị ga-ezere ịnya ụgbọ ala na ịme ihe omume nwere ike dị ize ndụ.

Ngwakọta na ụdị ntọhapụ

Ngwọta Emoxibel maka nchịkwa intraus + na intramuscular - mmiri mmiri ahụ enweghị agba ma ọ bụ nke dị obere na ammịnụ 5 ml, nwere:

• Ihe na-arụ ọrụ: emoxypine (methylethylpyridinol hydrochloride) - 30 g,
• Ihe ndi ozo: sodium hydrogen phosphate dodecahydrate, sulfur sodium, mmiri.

Mpempe akwụkwọ sel 1 ma ọ bụ 2 PC. 5 ampoules na kaadiboodu. Ntụziaka, ịchafụ.

Usoro onunu ogwu:

Nkọwa:
doro anya, mmiri na-acha odo odo ma ọ bụ nke dị ụcha.

Ngwakọta
1 liter: ike ọrụ: methylethylpyridinol hydrochloride (emoxypine) - 30 g,
ndị na-ebu ụzọ: sodium sulfite, sodium hydrogen phosphate dodecahydrate, mmiri maka injection.

Otu na-ere ọgwụ:

Koodu: C05CX

Omume ọgwụ.
Ọ bụ ihe mgbochi nke usoro radieshon n'efu, antihypoxant na antioxidant. Na-ebelata viscosity ọbara na nchịkọta platelet, na-abawanye ọdịnaya nke cyclic nucleotides (cAMP na cGMP) na platelet na akwara ụbụrụ, nwere ọrụ fibrinolytic, na-ebelata ike nke mgbidi vaskụla na ihe ize ndụ nke ọbara ọgbụgba, na-akwalite resorption ha. Na-agbasa arịa ọbara ọgbụgba, n'oge oke nke myocardial infarction na-egbochi ogo nke necrosis, na-eme ka mmekọrịta dị mma nke obi yana ọrụ ya. Site n'ọbara mgbali elu (BP) nwere mmetụta hypotensive. Na nnukwu nsogbu ischemic nke mgbasa akwara na-ebelata ogo mgbaàmà ọrịa ụbụrụ, na-eme ka iguzogide anụ ahụ na hypoxia na ischemia.

Mlọ ọgwụ
Mgbe ejiri ọgwụ 10 10 mg / kg rụọ ọrụ intravenly, ọkara ndụ bụ awa 0.3, mkpokọta nke CL bụ 0.2 l / min, olu pụtara oke nkesa bụ 5.2 l. Ọgwụ ahụ na-abanye ngwa ngwa n’arụ na anụ ahụ, ebe a na-edebe ya ma na-akụ ya. Achọpụtara metabolites ise nke methylethylpyridinol, nke ngwaahịa ndị nwere nkụda mmụọ na nke dịjuru anya nọchitere anya ya. Ọkpụkpụ methyl ethyl pyridinol na-amịpụta akụrụ. A na - ahụta oke 2-ethyl-6-methyl-3-hydroxypyridine-phosphate n'ime imeju. Site na ọrịa obi obi, bioavailability na-abawanye.

Ihe ngosi maka ojiji.
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