Neupomax - ntuziaka maka ọrụ

Filgrastim bụ repobintial granulocyte ogige na-akpali akpali. Bụ a protein si na 175 amino acid. Ọpụrụ iche na mkpụrụ ndụ. Escherichia colin'ime ngwa ọrụ mkpụrụ ndụ ihe nketa nke G-CSF mmadu. Nwere otu ihe ahụ dị ndụ dị ka G-CSFemepụtara na ahụ mmadụ. Na-akwalite mmụta neutrophils ọpụpụ ọkpụkpụ ha. Dịkwuo neutrophils n'ime ọbara kwuru n'ime awa 24.

Ihe ngosi maka ojiji

• neutropenia mgbe mmiri ọgwụ,
• mkpokota CPMC na-enye onyinye na ndị ọrịa
• neutropenia mgbe myeloablative ọgwụgwọ tupu ụmị ọkpụkpụ,
• idiopathic ma ọ bụ congenital neutropenia na ndị okenye na ụmụaka,
• ịnọgidesi ike neutropenia n'ime ndị ọrịa Nje HIV (enweghi ike nke usoro ọgwụgwọ ndị ọzọ).

Omume ọgwụ

Neupomax bụ ihe na-akpali akpali nke leukopoiesis. Neupomax nwere filgrastim, ihe ndọghachi azụ mmadụ na-akpali akpali nke gọọmentị na-akpali akpali (G-CSF). Akụrụngwa nọ n'ọrụ nwere ọrụ nke yiri G-CSF endogenous; ihe kemịkal nke filgrastim dị iche na endogenous compound site na N-terminal methionine ọzọ (filgrastim bụ protein na-enweghị glycosylated). A na - enweta ọgwụ na - arụ ọrụ nke ọgwụ ahụ site na iji teknụzụ DNA recombinant na sel cocher nke Escherichia, na - eme ka usoro mkpụrụ ndụ ihe nketa nke ewebata mkpụrụ ndụ nke na - etinye protein G-CSF.

Neupomax na-eme ka mmepụta nke neutrophils nwee ọrụ na-eju afọ, yana ntinye ha na akwara vaskụla site na sel ụmị ọkpụkpụ. Neupomax dị irè na neutropenia nke mmalite dị iche iche.

Pharmacodynamics nke ọgwụ Neupomax

Ntinye intravenous na subcutaneous nke filgrastim na-eduga n'ịdabere na ndaba kwụ ọtọ nke ọkwa ọbara ya. Olu nkesa filgrastim ruru 150 ml / n'arọ.

Ogologo ndụ ọkara nke filgrastim bụ awa 3.5, nkezi mkpochapụ bụ 0.6 ml / min / n'arọ.

Filgrastim fọrọ nke nta ka ọ ghara ịgwakọta (na ndị ọrịa na-agagharị na ụmị ọkpụkpụ na-aga n'ihu, bụ onye natara infgrastim na-aga n'ihu maka ụbọchị 28, enweghị akara nke mmụpụta ọgwụ ahụ).

Ofzọ nke ngwa

Neupomax ezubere maka parenteral subcutaneous ma ọ bụ nchịkwa intraven. A na-achịkwa azịza ya kwa ụbọchị n'okpuru ma ọ bụ n'ụdị infusions dị mkpirikpi n'ime akwara (ruo nkeji 30). Ọ bụrụ na ọ dị mkpa, a na-ahapụ Neupomax ka ọ bụrụ nke a na-agakọ kwa awa iri abụọ na anọ. Usoro ochichi, yana usoro onodu ogwu ya na oge ojiji nke usoro Neupomax, ndi okacha mara kpebisiri ike, n’iburu n’uche banyere njiri mara onye ọrịa a. Maka ọtụtụ ndị ọrịa, a na-ahọrọ usoro nchịkwa subcutaneous.

Mgbe ejiri subcutaneously na-achịkwa, a na-atụ aro ka ịgbanwee ebe ntụtụ na ntụtụ ọ bụla (ịgbanwe saịtị ntụtụ na-ebelata ohere ihe mgbu mgbe nchịkwa ọgwụ ahụ gasịrị).

Usoro onunu ogwu nke Neupomax n'oge cytotoxic chemotherapy

N'usoro ọkọlọtọ, usoro ọgwụgwọ 5 ,g / n'arọ nke ọrịa ka a na-edenyekarị otu ugboro n'ụbọchị. A na-ahụ maka ọgwụ a kwa ụbọchị subcutaneously ma ọ bụ intravenously site na infusion (ruo nkeji 30) na nlele ọbara mgbe niile. A na-eji ọgwụ ahụ eme ọgwụ ọgụgụ neutrophil.

Ntinye izizi nke filgrastim a erughi tupu awa iri abụọ na anọ gachara site na mmiri ọgwụ. Ogologo oge eji filgrastim ruru ụbọchị 14. Nyere udiri anumanu eji eme ihe, mgbe ejikota ya na induction ọgwụgwọ nke ụdị myelogenous leukemia, enwere ike iji uzo Neupomax mee ihe ruru ubochi iri ato na asatọ. N'ime ọtụtụ ndị ọrịa, e dere mmụba dị mkpirikpi na ọnụ ọgụgụ nke neutrophils na ụbọchị nke abụọ na nke atọ nke usoro ọgwụgwọ filgrastim. A naghị atụ aro ka ọ kwụsị ịgwọ ọrịa filgrastim ruo mgbe a na-enweta ọnụnọ neutrophil nkịtị mgbe a na-ezube ibelata nke ngosipụta ndị a (na ịkwụsị ịgwọ ọrịa, ohere nke inweta mmetụta ọgwụgwọ kwụsiri ike). Akwụsịrị ọgwụgwọ na Neupomax ma ọ bụrụ na ọnụ ọgụgụ zuru oke nke neutrophils na-abawanye karịa 10,000 / μl.

Usoro onunu ogwu nke Neupomax na usoro myeloablative with the other marrow transplantation

Themalite mmalite nke filgrastim maka ọgwụgwọ myeloablative na-esochi ntụgharị (autologous ma ọ bụ allogene) nke ụmị ọkpụkpụ bụ 10 μg / kg nke ibu ndidi. A na-a drugụ ọgwụ ahụ ọgwụ mgbochi intravenously (oge nke ntapu bụ 30 nkeji ma ọ bụ awa 24). Ọ ga - ekwe omume ntinye nke filgrastim site na subcutaneous 24-hour infusion.

A na-achịkwa usoro mmalite nke ngwọta Neupomax tupu oge elekere 24 ka emechara ọgwụgwọ ọgwụ cytotoxic ma ọ gafere karịa awa 24 mgbe a gbasịrị ụmị ọkpụkpụ.

Ogologo oge eji ihe Neupomax mee ihe na ọgwụgwọ myeloablative abụghị ihe karịrị ụbọchị 28. Ubọchi kwa ure nke filgrastim nwere ike idozi n’iburu n'uche neutrophils na ike nke ịba ụba ọnụ ọgụgụ ha. Mgbe ọnụ ọgụgụ neutrophil karịrị 1000 / μl maka ụbọchị atọ aga, ọnụọgụ nke filgrastim na-ebelata 5 μg / kg nke ibu onye ọrịa kwa ụbọchị. Y’oburu, mgbe emesigharịrị usoro, ọkwa neutrophil karịrị 1000 / forl maka ụbọchị atọ n’usoro, a na-akagbu idozi Neupomax. Ọ bụrụ na, mgbe ịgbanwere dose ma ọ bụ kagbuo ngwọta Neupomax, ọnụọgụ nke neutrophils na-agbadata erughị 1000 / ,l, ị kwesịrị ịlaghachi na nke mbụ nke filgrastim.

Usoro onunu ogwu nke Neupomax n'oge ochichi nke sel elu nke obara n’enwe ndi oria ojoo

Iji chịkọta sel azumazu ọbara, a na-edenye ndị ọrịa nwere ajọ ọrịa 10 μg / n'arọ nke ahụ kwa ụbọchị subcutaneously bolus ma ọ bụ infusionaneous infusion (maka awa 24) maka ụbọchị isii. Megide ndabere nke iji filgrastim, a na-eme leukapheresis abụọ n'usoro (ọ na-abụkarị ụbọchị nke ise na ụbọchị nke isii). Ọ bụrụ na leukapheresis ọzọ dị mkpa, a ga-aga n'ihu na njikwa nke filgrastim ruo mgbe usoro ikpeazụ dị.

Usoro onunu ogwu nke Neupomax mgbe ọgwụgwọ myelosuppressive megharia sel sel ọbara

Mgbe emechara myelosuppressive ọgwụgwọ, a na-edenyekarị filgrastim na dose 5 μg / kg nke onye ọrịa dị ka ntụtụ ụkwụ. Ọgwụ na Neupomax na-amalite ụbọchị mgbe ikpeazụ ọgwụgwọ nke chemotherapy. A na-ekpebi oge ihe eji eme ihe filgrastim site na ọkwa nke neutrophils na mgbanwe nke mgbanwe na ọnụ ọgụgụ ha; a na-atụ aro ka ọ nọgide na-eji nkwadebe Neupomax ruo mgbe a ga-enweta ụkpụrụ nkịtị nke ọkwa neutrophil. A na-eme Leukapheresis mgbe ọ ruru ogo neutrophil karịa 2000 / .l.

Usoro onunu ogwu nke Neupomax maka ichikota sel azumahia diri ndi n’enye onyinye ike maka ebumnuche

A na-adụ ndị na-enye ahụike ume ka ha na-achịkwa filgrastim na kilogram 10 mcg / kg dị arọ kwa ụbọchị. Ogologo oge ihe ọmụmụ a bụ ụbọchị 4-5, ebe 1-2 leukapheresis na-enye gị ohere inweta mkpụrụ ndụ 4 * 106 CD34 + n'arọ nke ịdị nnata. Enweghị data na nchekwa nke iji filgrastim na ndị na-enye onyinye dị mma n'okpuru afọ 16 na karịa afọ 60.

Usoro onunu ogwu nke Neupomax na ogwu nke na adighi ala ala

Site n'ụdị neutropenia, a na-atụzi filgrastim na kilogram 12 μg / n'arọ nke onye ọrịa kwa ụbọchị, na-enwe idiopathic na oge nkeropropropia, a na-atụzi filgrastim na nha 5 μg / kg nke ahụ dị kwa ụbọchị. N'ọnọdụ ndị dị otú a, a na-eji ọgwụ Neupomax achịkwa subcutaneously, enwere ike ike ị doseụ ọgwụ ahụ kwa ụbọchị n'ọtụtụ injections ma ọ bụ jikwa ya n'oge. Ekwesịrị ịga n'ihu na usoro ọgwụgwọ ahụ ruo mgbe ọnụnọ neutrophil ruru ihe karịrị 1500 / reachedl ruru. Mgbe enwetara ọnụ ọgụgụ dị mkpa nke neutrophils, ọ dị mkpa iji họrọ opekempe nke filgrastim, nke ga-agba mbọ hụ na ọnụọgụ ndị neutrophils ka a na-arụ.

Nyere nzaghachi nke onye ọrịa na usoro ọgwụgwọ filgrastim, mgbe izu 1-2 gasịrị, enwere ike belata ma ọ bụ nwekwuo ugboro abụọ. A na-emezigharị usoro ọzọ 1 oge n’ime izu 1-2. A na-ahụta oke kachasị mma iji kwe ka a nọgide na-enwe ọkwa nke neutrophils na korido 1500-10000 / .l. Na ọrịa dị egwu, a na-ahapụ mmụba ngwa ngwa karịa nke filgrastim.

Achọpụtaghị nchekwa nke ọgwụgwọ ogologo oge na filgrastim na usoro kwa ụbọchị nke ihe karịrị 24 mcg / kg / ụbọchị n'ime ndị ọrịa nwere ụdị ọgbụgba siri ike nke neutropenia.

Usoro ọgwụgwọ Neupomax maka neutropenia n'ime ndị ọrịa bu nje HIV

Themalite ọgbụgba nke filgrastim maka ndị ọrịa bu nje HIV na neutropenia bụ 1-4 μg / kg nke ahụ dị kwa ụbọchị. A ga-etinyerịrị dose ahụ iji nweta ọkwa nkịtị nke neutrophils. Dabere na ntachi obi nke filgrastim na ịdị omimi nke mmụba na ọnụ ọgụgụ nke neutrophils, enwere ike ịbawanye ọnụọgụ nke ngwọta Neupomax. Ejila ihe karịrị 10 mcg / n'arọ nke ọrịa ndidi kwa ụbọchị.

Usoro ị Neụ ọgwụ Neupomax na ụfọdụ ndị ọrịa

Maka ụmụaka gbara afọ 16, a na-edenye filgrastim na usoro ndị a tụrụ aro maka ndị okenye. Ekwesịrị ịgbakọ ọnụọgụ nke filgrastim na ọrịa ụmụaka dabere na ịdị arọ na nha ike nke ọkwa nke neutrophils.

Ndị ọrịa agadi achọghị ọgwụ mgbanwe nke Neupomax.

Ndụmọdụ maka dilution Neupomax

Mgbe ejiri subcutaneously na-achịkwa, Neupomax adịghị diluted.

Maka nkwadebe nke usoro infusion maka nchịkwa drip, naanị 5% dextrose solution ga-eji. Amachibidoro iji 0.9% sodium chloride (ihe ngwọta adịghị adabako).

Okwesiri iburu n'uche na ọgwụ ogwu Neupomax na ntinye nke 2-15 μg / ml nwere ike ịmịcha ya na iko na iko. Iji gbochie nnabata nke filgrastim site na mgbidi nke vial, a na-atụ aro ka ịgbakwunye yaumum mmadụ na ntinye (mkpokọta ikpeazụ nke albumin na ngwọta infusion kwesịrị 2 mg / ml). Ọ bụrụ na ngụkọ ikpeazụ nke filgrastim karịrị 15 μg / ml, a chọghị mgbakwunye nke albumin. Mkpuchi ọgwụ Neupomax na mkpụnye ihe na-erughị 2 isg / ml amachibidoro.

Ntụziaka pụrụ iche maka iji ọgwụ ọgwụ Neupomax

Filgrastim ọgwụgwọ nwere ike ịme naanị site na onye ọkachamara nwere ahụmịhe site na iji ihe ndị na-akpali ime mmụọ, ma dabere na enwere ikike nchọpụta. Ekwesịrị ịhazi mkpokọta sel na apheresis naanị na ụlọ ọrụ ahụike ọkachamara.

Ndị ọrịa nwere nnukwuropropia na-adịghị ala ala kwesịrị iji nlezianya na-eduzi nchọpụta ọdịiche tupu ịmalite ịgwọ ọrịa filgrastim iji wepu ọrịa ọbara ọgbụgba ndị ọzọ (gụnyere anaemia, myelogenous leukemia, myelodysplasia). Tupu ịmalite ọgwụgwọ, ọ dị mkpa iji nyocha nyocha cytogenetic na morphological nke ụmị ọkpụkpụ.

Usoro ọgwụgwọ Neupomax ga-ekwe omume naanị na iji nlezianya na-ahụ maka onyonyo onyunyo na-ahụkarị ihe na -echepụta usoro leukecyte usoro na platelet (nyocha nke mbụ tupu emee filgrastim, mgbe ahụ, a na-emeghachi ya, ọ dịkarịa ala ugboro abụọ n'izu site na iji ọgwụ na ọ dịkarịa ala ugboro atọ n'izu na mkpokọta nke steepụ ahụ dị ala mkpụrụ ndụ ọbara). Ọ bụrụ na a na-eji filgrastim emekọta mkpụrụ ndụ ọbara, na-abawanye na ọnụ ọgụgụ ọbara ọcha dị ihe karịrị 100,000 / orl ma ọ bụ mbelata ọnụ ọgụgụ platelet erughị 100,000 / ,l, Neupomax kwesịrị ịkagbu ma ọ bụ belata ọgwụ nke filgrastim. Ekwesiri iburu n'uche na ọgwụ Neupomax anaghị egbochi ịdaba anaemia na thrombocytopenia metụtara myelosuppressive chemotherapy.

Onweghi ihe akaebe banyere mmetụta esere na graft na mmeghachi omume nnabata.

Ọ dị mkpa iji nyochaa nsonaazụ mmamịrị mgbe niile n'oge ọgwụgwọ na Neupomax (wezuga proteinuria na hematuria).

A na-atụ aro ka nyochaa ọnọdụ morphological nke ọrịa ahụ n'oge ọgwụgwọ na Neupomax.

Ọ dị mkpa ịchịkwa ịdị ukwuu na nhazi nke anụ ahụ ọkpụkpụ n'ime ndị ọrịa nwere ọnya ọkpụkpụ ma ọ bụ osteoporosis n'oge ọgwụgwọ ogologo oge na Neupomax.

Nsonaazụ

Na-emegide usoro ọgwụgwọ ya na ọgwụ Neupomax n'ime ndị ọrịa, ọdịdị nke mmeghachi omume ndị a na-adịghị mma ga-ekwe omume:

• Usoro akwara: mgbu mgbu, myalgia, ọnya ọkpụkpụ, osteoporosis.
• Afọ ime: ọnya ọgbụgba, ọnya ọgbụgba, anorexia, vomiting, ọgbụgbọ.
• Ọbara ọbara: leukocytosis, neutrophilia, thrombocytopenia, anaemia, na-abawanye na ngwụcha nke spleen.
• Usoro iku ume: nsogbu iku ume, ngụgụ.
• CVS: lability ọbara mgbali, vasculitis.
• Nchọpụta ụlọ nyocha: mụbara (na-atụgharị) ọkwa nke uric acid, dectrogenase lactate, gamma glutamyl transferase na alkaline phosphatase na ọbara, hypoglycemia dị mkpụmkpụ (mgbe erichara nri).

Na mgbakwunye, n'oge ọgwụgwọ Neupomax ngwọta, mmepe nke proteinuria na hematuria, asthenia, ike ọgwụgwụ, petechiae, imi na erythema nodosum ka edere na ụfọdụ ndị ọrịa.

Mgbe ị na-eji ọgwụ Neupomax, ndị ọrịa nwere ike ịnwe mmeghachi omume hypersensitivity n'ụdị akụkụ ihu, urticaria, ọdịda okuku ume, hypotension hypotension, na tachycardia.

Mmeghe nke nnukwu ụdị nke myeloid leukemia na myelodysplastic syndrome na ndị ọrịa nwere ụdị akpọropropia na-adịghị ala ala kwuru. Ekwenyeghi njikọ njikọ nke ọrịa ndị a na ọgwụgwọ filgrastim, agbanyeghị, ekwesịrị ịdebe Neupomax nye ndị ọrịa na - enwe nnukwu nsogbu na - adịghị ala ala nanị site na iji nlezianya na nyocha cytogenetic nke ụmị ọkpụkpụ (ọbụlagodi otu ugboro na ọnwa iri na abụọ). Site na mmepe nke mgbanwe cytogenetic na ụmị ọkpụkpụ, a ga-enyocha ihe egwu na uru ndị ọzọ enwere ike na ọgwụgwọ ọzọ na filgrastim yana nhọrọ nke ịkwụsị ọgwụ Neupomax.

Mmepe nke arịa ọrịa leukemia na MDS chọrọ ịkwụsị Neupomax.

Neupomax anaghị abawanye ugboro na ogo ihe ọghọm nke ọgwụ cytotoxic.

Filgrastim nwere ike ibute mmụba dị ukwuu n'ọtụtụ sel sel, nke ekwesịrị ịtụle n'oge ọgwụgwọ ndị ọrịa nwere ọrịa sickle cell.

Ihe ngbanwe

Edeghị Neupomax maka ndị ọrịa nwere ntachi obi n'ihe filgrastim ma ọ bụ ihe enyemaka nke azịza ahụ.

Ejighị Neupomax na ọgwụgwọ nke ndị ọrịa nwere nnukwu congropital neutropenia (Costmann syndrome) yana nkwarụ cytogenetic.

Enweghị ike iji Neupomax mee ka ọgwụ ọgwụ cytotoxic nke chemotherapeutic chemotherape karịa nke ndị a tụrụ aro ya.

Achọrọ ịkpachara anya mgbe ị na-eji ọgwụ Neupomax na ndị ọrịa nwere ajọ ọrịa na ụdị ọrịa ụdị myeloid (gụnyere ọrịa myelogenous leukemia), yana ọrịa cell.

Enweghị data na nchekwa nke filgrastim na ndị ọrịa nwere autoimmune neutropenia.

Ime

Emebeghi nchekwa nke ogwu na filgrastim nke nwanyi di ime. Ọ dị mkpa iji nyochaa nyocha nke ọghọm na uru dị na ya tupu ịdebanye Neupomax nye ụmụ nwanyị n'oge afọ ime.

Enweghị data na nbanye Neupomax n'ime mmiri ara. Ọ dị mkpa iji mezue ara tupu ịmalite ọgwụgwọ Neupomax.

Mkparịta ụka ọgwụ ọjọọ

Achọpụtaghị nchekwa nke iji filgrastim yana ọgwụ ọgwụ cytotoxic myelosuppimidia na-eji na usoro ọgwụgwọ (mgbe a na-enye ọgwụ ndị a n'otu ụbọchị).

Enwere ihe akaebe nke mmụba na ogo nke neutropenia mgbe ị na-eji filgrastim na 5-fluorouracil.

Agụghị ojiji nke filgrastim yana ihe ndị ọzọ na-eto eto, yana cytokines.

O kwere omume iwelie arụmọrụ nke filgrastim mgbe ejiri ya na nkwadebe lithium (nkwadebe lithium na-akpali ntọhapụ nke neutrophils).

Ngwọta Neupomax ekwekọghị na 0.9% sodium chloride.

Ọnọdụ nchekwa

Ekwesịrị ịchekwa Neupomax site na iru ụmụaka agaghị enweta okpomọkụ na ogo Celsius 2-8.

Amachibidoro iji usoro a dozie.

Ndụ shelf bụ afọ 2.

Mgbe ịmepechara karama ahụ, enweghị ike ịchekwa ihe ngwọta ya.

Granogen, Zarsio, Immugrast, Leukostim, Leucite, Myelastra, Neutrostim, Tevagrastim, Filgrastim, Filergim.

Usoro onunu ogwu:

ihe ngwọta maka nchịkwa intravenous na subcutaneous.

1 ml nke ihe ngwọta nwere:

ike ihe: filgrastim 300 mcg (nde iri atọ)

ndị mgbe ochie: glacial acetic acid, sodium hydroxide (sodium hydroxide), sorbitol (sorbitol), polysorbate 80, mmiri maka injection.

Na-acha uhie uhie ma ọ bụ ubé opalescent, adịghị acha mmiri ma ọ bụ ubé mmiri mmiri.

Ngwongwo ogwu

Mlọ ọgwụ.

Ihe na-arụ ọrụ nke ọgwụ ahụ bụ filgrastim - ihe na-akpali akpali mmadụ na-eme ka ọchịchị na-akpali akpali nke gọọmentị na-akpali akpali (G-CSF). Filgrastim nwere otu ihe dị ndụ dị ka G-CSF na-efe efe, ma dị iche na nke ikpeazụ naanị na ọ bụ protein na-enweghị glycosylated nwere mgbakwunye N-terminal methionine ọzọ. A na - ekewa Filgrastim site na teknụzụ DNA ọzọ site na mkpụrụ ndụ nke nje ahụ Esherichiacoli, ngwa ọrụ mkpụrụ ndụ ihe nketa nke webatara usoro mkpụrụ ndụ ihe omimi na-etinye protein G-CSF.

Filgrastim na-akpali okike nke na - arụ ọrụ ma na - ahapụ ha n'ime ọbara site na ụmị ọkpụkpụ; a na - eji ya eme ihe na - agwọ ndị ọrịa nwere njikọ dị iche iche.

Mlọ ọgwụ

Ma ya na nchịkwa intravenous na subcutaneous nke filgrastim, ana-ahụta ezigbo akara kwụ ọtọ na ịta ahụ ya na dose ahụ. Olu nke ikesa n’ọbara bụ ihe dịka 150 ml / n'arọ.

Ogologo ndụ ọkara nke filgrastim sitere na serum bụ ihe dịka awa 3.5, ọnụego mkpochapụ bụ ihe dịka 0.6 ml / min / kg.

Anwe ọnya na-aga n'ihu na-eme ihe ruru ụbọchị 28 ruo ndị ọrịa mgbe ọrịa ụmị ọkpụkpụ na-esoghị akara mmụba na mmụba na ọkara ndụ.

Mmetụta akụkụ

Site na usoro mọzụlụ: ihe mgbu na ọkpụkpụ, akwara na nkwonkwo, osteoporosis.

Site na nri digestive: anorexia, afọ ọsịsa, ịba ọcha n'anya, ọgbụgbọ na ọgbụgbọ.

Mmeghachi omume nfụkasị ahụ: akpukpo anụ ahụ, urticaria, akụkụ ihu, ọsụsọ, mkpụmkpụ ume, mbelata ọbara mgbali, tachycardia.

Site na akụkụ ahụ dị na hemopoietic: neutrophilia na leukocytosis (n'ihi nsonaazụ nke ọgwụ ọgwụ nke filgrastim), anaemia, thrombocytopenia, ịbawanye ụba na mgbapu nke spleen.

Na akụkụ akụkụ okuku ume: okenye ọrịa iku ume nsogbu, nkuume infiltrates.

Si usoro obi: na-ebelata ma ọ bụ na-abawanye ọbara mgbali, vasculitis akpụkpọ.

Site na egosi ulo laabu: mmụba mgbanwe enwere na ọdịnaya nke lactate dehydrogenase, alkaline phosphatase, gamma-glutamyltransferase, uric acid, hypoglycemia dị mkpụmkpụ mgbe ị risịrị nri, ọ dịkarịghị ala: proteinuria, hematuria.

Ndị ọzọ: isi ọwụwa, ike ọgwụgwụ, adịghị ike nke izugbe, imi imi, petechiae, erythema nodosum.

Filgrastim adịghị eme ka ihe ndị dị njọ na ọgwụgwọ cytotoxic dịkwuo njọ.

Mmekọrịta na ọgwụ ndị ọzọ

Nchekwa na arụmọrụ nke nchịkwa filgrastim n'otu ụbọchị ọgwụ myelosuppressive antitumor edobebeghị.

Enwere akụkọ dị iche iche na-abawanye ụba nke neutropenia ebe nhọpụta nke filgrastim na 5-fluorouracil.

Ugbua enweghi ihe akaebe banyere ihe ndi mmadu na emekorita ya na cytokines ndi ozo.

Lithium, nke na-eme ka mwepu nke neutrophils, nwere ike ịkwalite nsonaazụ nke filgrastim.

Ngwa ogwu ekwekorita na 0.9% chloride solution.

Ntụziaka pụrụ iche

Ekwesịrị ịgwọ ọgwụgwọ Neypomaksom naanị n'okpuru nlekọta nke dibịa nwere ahụmịhe iji ihe ndị na-akpali akpali, yana ikike nchọpụta dị mkpa. Ekwesịrị ịmalite usoro mkpokọta sel na apheresis n'ụlọ ọrụ nlekọta ahụike.

Achọpụtaghị nchekwa na ịdị mma nke filgrastim na ndị ọrịa nwere ọrịa myelodysplastic na ọrịa lekonia na-adịghị ala ala, yabụ agaghị atụ aro iji filgrastim maka ọrịa ndị a. Ekwesịrị ị attentiona ntị na nchọpụta ọdịiche dị n'etiti ọrịa myelogenous ụkwara nta na nsogbu ọgbụgba nke ọrịa myelogenous leukemia na-adịghị ala ala.

Tupu nhọpụta nke Neupomax na ndị ọrịa nwere nnukwuropropropia na-adịghị ala ala (TCH), a ga-eji nlezianya mee nchọpụta ọdịiche iji wepu ọrịa ndị ọzọ dị n'ọbara dịka ọrịa akwara na myelodysplasia, na ọrịa mialogenous leukemia (morphological na cytogenetic analysis of the marrow bone) ga-emerịrị tupu ọgwụgwọ).

Site n'iji filgrastim mee ihe na ndị ọrịa nwere CTN, enweela ọnọdụ nke mmepe myelodysplastic syndrome na nnukwu myeloid leukemia. N'agbanyeghi eziokwu na njikọta n'etiti mmepe nke ọrịa ndị a na iji filgrastim, ekwesịrị iji ọgwụ ahụ mee ihe na TCH na nlezianya n'okpuru njikwa morphological na nyocha cytogenetic nke ụmị ọkpụkpụ (1 oge na ọnwa 12). Mgbe ihe ndị metụtara cytogenetic na ụmị ọkpụkpụ, a ga-eji nlezianya nyochaa ihe egwu na uru nke ọgwụgwọ ọzọ na filgrastim. Site na mmepe nke MDS ma ọ bụ leukemia, a ga-akwụsị Neupomax.

Ekwesịrị ịmalite usoro ọgwụgwọ Neupomax n'okpuru nleba anya ọnụ ọgụgụ ọbara n'ozuzu ya na ọnụ ọgụgụ leukocyte na platelet (tupu ịmalite ọgwụgwọ na mgbe ahụ ugboro 2 n'izu na usoro ọgwụgwọ ọkọlọtọ na ọ dịkarịa ala ugboro atọ n'izu na mkpokọta PSCC na ma ọ bụ na-enweghị mmịnye ụmị ọkpụkpụ na-esote). Mgbe ị na-eji Neupomax n'ịhazi PSCC, a ga-akwụsị ọgwụ ahụ ma ọ bụrụ na ọnụọgụ ndị leukocytes karịrị 100,000 / .l. Site na mpempe platelet kwụsiri ike na-erughị 100,000 / ,l, a na-atụ aro ka ị kwụsịtụ ịgwọ ọrịa filgrastim ma ọ bụ belata ya.

Filgrastim anaghị egbochi thrombocytopenia na anaemia n'ihi ọgwụ myelosuppressive.

N'oge ọgwụgwọ Neupomax, ekwesịrị ịme urinalysis mgbe nile (ewezuga hematuria na proteinuria) na a ga-enyocha ogo spleen.

Ekwesịrị iji Filgrastim jiri nlezianya mee ihe na ndị ọrịa nwere ọrịa sickle cell n'ihe metụtara ohere enwere ike ịdị na-abawanye ọnụ ọgụgụ mkpụrụ ndụ sickle.

Achọpụtaghị nchekwa na ịdị mma nke ọgwụ ahụ n'ime ụmụ amụrụ ọhụrụ na ndị ọrịa nwere ọrịa neutropenia.

Ndị ọrịa nwere ọnya ọkpụkpụ na osteoporosis na-anata ọgwụgwọ na Neupomax ruo ihe karịrị ọnwa 6 ka egosipụtara na-achịkwa njupụta nke ọkpụkpụ.

Ebidobeghi nsonaazụ filgrastim na aka aka na aka onye agha.

Mpempe mwepụta.

Ngwọta maka nchịkwa intravenous na subcutaneous, 300 μg (nkeji iri atọ) na 1 ml. Na 1.0 ml (300 mcg, nde 30 nde) ma ọ bụ 1.6 ml (480 mcg, nde 48 nde) na karama iko, jiri akara na-akwụsị ya site na ngwakọta roba na okpu aluminom na-agba ọsọ.

A na-etinye karama 5, ndị a na-akwakọba na ngwungwu ihe nkiri PVC yana ntuziaka maka iji, etinye ha n'ime mkpọ kaadiboodu.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

P / c ma ọ bụ n'ụdị infusions intravenous dị mkpụmkpụ (n'ime nkeji 30), kwa ụbọchị ruo ọnụọgụ nke neutrophils ruru ntakịrị elekere (nadir) wee laghachi na oke kwesịrị. Isgwakọta ọgwụ ahụ na ọgwụ dextrose 5%.

Szọ s / c kachasị mma nke nchịkwa ọgwụ. Nhọrọ nke uzo ochichi na-esite na onodu ogwu a ka aputara.

Usoro ọgwụgwọ cytotoxic na-ahụkarị: 0,5 nde nkeji (5 mcg) / kg otu ugboro n'ụbọchị. A na-elekọta ọgwụ mbụ tupu awa iri abụọ na anọ agachaa mmiri ọgwụ cytotoxic. Ogologo oge ọgwụgwọ dị ka ụbọchị iri na anọ. Mgbe induction na nchịkọta nkwonkwo nke ọrịa myelogenous na-arịa oké ọrịa, oge ọgwụgwọ nwere ike ịbawanye ruo ụbọchị 38, dabere na ụdị, dose, na usoro cytotoxic chemotherapy ejiri. A na-ahụkarị mgbakwunye na ọnụ ọgụgụ nke neutrophils 1-2 ụbọchị mgbe ịmalite ọgwụgwọ. Iji nweta nsonaazụ ọgwụgwọ kwụsiri ike, ọ dị mkpa ịga n'ihu na ọgwụgwọ ruo mgbe ọnụọgụ nke neutrophils na-agafe opekempe a tụrụ anya ya wee ruo ụkpụrụ nkịtị. A naghị atụ aro ka ịkagbu ọgwụ ahụ tupu oge a, ọnụọgụ nke neutrophils na-agafe opekempe a tụrụ anya. A na-akwụsị ọgwụgwọ ma ọ bụrụ na ọnụ ọgụgụ zuru oke nke neutrophils mgbe ndị nadir ahụ ruru 1 puku / µl.

Mgbe ọgwụgwọ myelo-ablative, nke a na-esochi site na ndọghachi azụ ma ọ bụ usoro allogeneic ọkpụkpụ ụmị ọkpụkpụ: sc ma ọ bụ iv infusion (na 20 ml nke 5% dextrose solution). Ọgwụ mbụ bụ 1 nde nkeji ọgwụ a (10 mcg) / n'arọ kwa ụbọchị na / dopu ma ọ bụ nkeji 30 ma ọ bụ awa 24 ma ọ bụ site na inf na-aga n'ihu na awa 24. be kwesịrị ị beụ ọgwụ mbụ ọ gafere tupu awa 24. mgbe achara cytotoxic, yana iji ụmị ọkpụkpụ mee - ọ dịghị oge ọ gafere elekere 24 ka mkpụrụ ụmị ọkpụkpụ na - agbakwa. Ogologo oge ọgwụgwọ abụghị ụbọchị 28. Mgbe mbelata nke oke nke neutrophils (nadir), a na-emegharị kwa ụbọchị na-adabere n'ike nke ọnụ ọgụgụ nke neutrophils. Ọ bụrụ na ọnụọgụ nke neutrophils karịrị 1 puku / forl maka ụbọchị atọ ga-agafe, ọnụọgụ belata belata nde 0,5 / n'arọ / ụbọchị, mgbe ahụ ọ bụrụ na ọnụ ọgụgụ zuru oke nke neutrophils karịrị 1 puku / forl maka ụbọchị atọ na-esote, ọgwụ ahụ na-akagbu. Ọ bụrụ na n'oge usoro ọgwụgwọ ọnụ ọgụgụ zuru oke nke neutrophils na-erughị 1 puku / μl, a na-amụba dose ahụ dabere na atụmatụ enyere.

Mkpokọta mkpụrụ ndụ ọbara dị gburugburu (PSCC) mgbe ọgwụgwọ myelosuppressive na-esochi site na ntụgharị nke onwe nke PSCC nwere ma ọ bụ na-enweghị ntụgharị ọkpụkpụ ma ọ bụ na ndị ọrịa nwere myeloablative ọgwụgwọ sochiri mmịnye nke PSCC: 1 nde nkeji (10 mcg) / kg kwa ụbọchị site na-aga n'ihu 24 awa s / c infusion ma ọ bụ ngbanye s / c 1 oge kwa ụbọchị maka ụbọchị 6 n'usoro. A na-atụ aro ka ọ rụọ ọrụ leukapheresis atọ n'usoro n'ụbọchị nke 5th, 6 na 7.

Ntughari nke PSCA mgbe nnagide myelosuppressive: 0,5 nde nkeji (5 μg) / kg kwa ụbọchị site na ntụtụ kwa ụbọchị, na-amalite site na ụbọchị 1st mgbe ọgwụgwọ kemịkalụ gwụchara ruo mgbe ọnụ ọgụgụ neutrophils gafere na nke a tụrụ anya ma rute nkịtị. ụkpụrụ. Ekwesịrị ịrụ ọrụ Leukapheresis n'oge oge ọnụ ọgụgụ zuru oke nke neutrophils na-ebili na erughị 500 ruo 5 puku / μl. Maka ndị ọrịa anabatabeghị chemotreapia, otu nnọkọ leukapheresis ezuola. N'ụdị ndị ọzọ, a na-atụ aro ka ha duzie oge leukapheresis.

Ntughari nke PSCC n’onyinye ndi nwere ezi ahuhu maka inyeghari allogene: s / c 1 nde (10 μg) / kg / ubochi nke 4-5 n’enye otutu CD34 + 4 nde / kg.

Neutropenia siri ike: sc kwa ụbọchị, otu ugboro ma ọ bụ ọtụtụ ọgwụ were were. Site na congropital neutropenia, usoro izizi bụ 1.2 nde nkeji (12 μg) / kg / ụbọchị, yana idiopathic ma ọ bụ oge nkejiropropenia - ọkara nde 0.5 (5 μg) / kg / ụbọchị ruo mgbe mmụba kwụsiri ike na ọnụ ọgụgụ nke ndị na-anọchi anya karịa karịa 1500 / μl. Mgbe emechara ọgwụgwọ ọgwụgwọ ahụ, ekpebiri obere opekempe iji nọgide na-enwe ọnọdụ a, a chọrọ nchịkwa ogologo oge kwa ụbọchị. Mgbe izu 1-2 gachara, enwere ike ịgbatị okpukpu abụọ ma ọ bụ belata 50%, dabere na nzaghachi onye ọrịa na usoro ọgwụgwọ. Nke a, izu 1-2 ọ bụla, ị nwere ike ịmeghari otu ihe iji dozie ọnụ ọgụgụ nke neutrophils na ngụkọta nke 1.5-10 puku / μl. Na nnukwu ọrịa, usoro nwere oke mmụba ngwa ngwa nwere ike iji. Na 97% nke ndị ọrịa zara ọfụma maka ọgwụgwọ, achọpụtara mmetụta ọgwụgwọ zuru oke na usoro onyonye ruru 24 mcg / kg / ụbọchị. Dosebọchị kwa ụbọchị ekwesịghị ịkarị 24 mcg / kg / ụbọchị.

Neutropenia na nje HIV: usoro mbụ bụ 0.1-0.4 nkeji (1-4 μg) / n'arọ / otu ugboro, s / c iji mee ka ọnụọgụ nke neutrophils dịkwuo elu. Oke kachasị kwa ụbọchị bụ 10 mcg / kg. Normalization nke ọnụ ọgụgụ nke neutrophils na - abụkarị mgbe ụbọchị 2 gachara. Mgbe o mechara nsonaazụ ọgwụgwọ, ihe mmezi bụ 300 mcg / ụbọchị 2-3 ugboro n'izu dịka atụmatụ ọzọ. Na-esote, enwere ike ịhazigharị otu onye na ọgwụ ogologo oge iji nọgide na-enwe ọnụọgụ nke ihe karịrị 2 puku / μl.

N'ime ndị ọrịa agadi, anaghị achọ mmegharị dose.

Ndụmọdụ maka ị ofụ ọgwụ ọ bụla na ụmụaka bụ otu ihe ahụ maka ndị okenye na-anata ọgwụ myelosuppressive.

Ọ bụrụ na ọgwụ a etinyere na mkpokọta ihe na-erughị 1.5 nde nkeji (15 μg) / ml, mgbe ahụ, a ga-agbakwunye serum albumin mmadụ ka ọ bụrụ nchikota nke albumin bụ 2 mg / ml (dịka ọmụmaatụ, na nsonaazụ ikpeazụ nke 20 ml, ngụkọta nke ọgwụ ahụ erughị nde 30 Ekwesịrị ịhazi ED (300 μg) na 0.2 ml nke ihe ngwọta 20% nke albumin mmadụ). Cannweghị ike ịgwagbu ọgwụ ahụ na mkpokọta ikpeazụ nke erughị 0.2 nde (2 μg) / ml.

Neupomax, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

N'ọnọdụ ka ukwuu, a na-eji ọgwụ ahụ eme ihe kwa ụbọchị subcutaneously, n'ọnọdụ ụfọdụ - infusion (igbari naanị na 5% ngwọta dextrose) Nhọrọ nke uzo ochichi na usoro onodu ogwu Neupomax dabere na onodu ogwu. Usoro ọgwụgwọ dị mgbagwoju anya, ha dị iche na ọrịa na ọnọdụ dị iche iche. Lee ụfọdụ n’ime ha.

Ka emechara mmiri ọgwụ họpụta 5 mcg / kg otu ugboro kwa ụbọchị s / c kwa ụbọchị ruo mgbe ọ bụla neutrophils. A na-elekọta ọgwụ nke mbụ otu ụbọchị mgbe njedebe ahụ gasịrị mmiri ọgwụ. Ogologo ọgwụgwọ ya dị izu abụọ. Emechaa ọgwụgwọ induction nnukwu myeloid leukemia oge ọ ga-eji ọgwụgwọ ga-abụ ụbọchị 38. Mụbaa na ọnụ ọgụgụ neutrophils Achọpụtara ka ụbọchị 1-2 gachara, iji nweta nsonaazụ kwụsiri ike, ekwesighị ịkwụsị ọgwụgwọ.

Usoro ọgwụgwọ Myeloablative tupu ịmịnye ụmị ọkpụkpụ

Ọgwụgwọ na-amalite site na 10 mcg / kg kwa ụbọchị, nke a na-achịkwa ya mgbe ọ bụla. Ogologo oge ọgwụgwọ ya dị ụbọchị 28.

Ntughari CPMC na-enye onyinye - 10 mcg / kg 1 oge kwa ụbọchị, subcutaneously ruo ụbọchị 5 na njikwa ọzọ leukapheresis.

Ntughari CPMC na ndị ọrịa na-eme mmiri ọgwụ - 5 mcg / n'arọ otu ugboro n'ụbọchị, subcutaneously, kwa ụbọchị ruo normalization neutrophils. Leukapheresis rụrụ mgbe neutrophils ruru ụkpụrụ> 2000 / μl.

Neutropenia n'ime ndị ọrịa Nje HIV - 1-4 mcg / n'arọ 1 oge kwa ụbọchị, subcutaneously ka ịhazi ụkpụrụ neutrophils. Tinyezie na usoro mmezi - 3 mcg / kg kwa ụbọchị.

Mlọ ọgwụ

Site na ntinye / abanye na s / na ntinye nke Neupomax, a na-ahụta ezigbo akara kwụ ọtọ nke ndọtị nke filgrastim na dose ahụ.

Olu nke nkesa na-ahapụ ihe dịka 150 ml / n'arọ. Mkpuchi ala dị 0.6 ml / min / n'arọ.

Obere ọkara ndụ bụ ihe dịka awa 3.5.

Site na ngụkọta nke Neupomax na-aga n’ihu ruo ụbọchị iri abụọ na asatọ, ndị ọrịa na-enwetara ụmị ọkpụkpụ akpaghị aka enwebeghị mmụba na ọkara ndụ na nchịkọta nke ihe arụ ọrụ.

Ntuziaka maka iji Neupomax: usoro na usoro onunu ogwu

Ejiri Neupomax mee sc dị n'ụdị injections ma ọ bụ iv n'ụdị infusions 30 dị mkpụmkpụ. Ọzọkwa, ọ bụrụ na ọ dị mkpa, sc ma ọ bụ nchịkwa intravenous n'ụdị infusus-24 awa ga-ekwe omume. Dọkịta na-ahọrọ ụzọ kachasị mma nke nchịkwa dabere na ọnọdụ ụlọ ọrụ a kapịrị ọnụ nke onye ọrịa, mana a na-ewere ụzọ ụzọ nchịkwa nke ọgwụ ahụ ka ọ ka mma karịa.

Kwa ụbọchị, a na-atụ aro ka ịgbanwee ebe ntinye ahụ, nke a ga-ezere ihe mgbu n'oge iwebata ngwọta.

Iwu maka ịkwadebe ihe ngwọta:

1. Site na nchịkwa subcutaneous, Neupomax anaghị agba nkịtị. Ọ bụrụ na ọ dị mkpa, infusion dị ka ihe mgbaze site na iji usoro dextrose 5%.
2. N'ihi ọgwụ mgbochi ọgwụ, ọ machibidoro iji slorum chloride 0.9% nke dilution.
3. Neupomax a gbanyere mkpọrọgwụ na 2-15 μg / ml nwere ike ịbụ plastik na iko. Iji gbochie mmịpụta, ọ dị mkpa ịgbakwunye serum albumin mmadụ na ihe ngwọta, a na-agbakọ ọnụọgụ ya nke na itinye uche na ngwọta ikpeazụ bụ 2 mg / ml.
4. Ekwesighi ịgbakwunye Albumin na Neupomax dil dil na mgbakwunye 15 15g / ml.
5. Ekwesighi iji Neupomax gbajiri n'ime ihe ruru 2 μg / ml.

Usoro Usoro Chemotherapy Cytotoxic

Usoro a tụrụ aro bụ 5 mg kwa n'arọ nke ịdị arọ otu ugboro kwa ụbọchị ma ọ bụ iv n'ụdị infusion nkeji iri atọ.

A na-elekọta ọgwụ nke mbụ tupu elekere iri abụọ na anọ mgbe ngwụsị kemịkal cytotoxic.

A na-eji Neupomax kwa ụbọchị ruo mgbe, mgbe atụtụsịrị ọnụego elekere neutrophils kachasị atụ anya, a na-eweghachi ọnụọgụ ha na nkịtị, mana ọ bụghị ihe karịrị ụbọchị 14. Mgbe o ruru ụkpụrụ, a kagbuo Neupomax.

Enwere ike ịbawanye oge nke ọgwụgwọ ahụ ruo ụbọchị 38 na ndị ọrịa na-anata nkwanye na usoro ọgwụgwọ maka njikọta ọrịa leukemia nnukwu. N'okwu a, buru n'uche ụdị usoro ọgwụgwọ chemotherapy, ụdị ya na ụdị ya.

A na-ahụkarị mgbakwunye na ọnụ ọgụgụ nke neutrophils 1-2 ụbọchị mgbe mmalite nke iji filgrastim. Iji mezuo mmetụta ọgwụgwọ kwụsiri ike, ekwesighi ịkwụsị ọgwụgwọ ruo mgbe ebutere ụkpụrụ nke neutrophil nkịtị mgbe mbelata ọnụ ọgụgụ ha kacha atụ anya. N'ihe banyere ọnụ ọgụgụ zuru oke nke neutrophils karịa 10,000 / ,l, a kagbuo Neupomax.

Neutropenia na-adịghị ala ala (TCH)

Initialụ ọgwụ kwa ụbọchị bụ: na-enwe njikọ nne na nna - 12 mcg / n'arọ, ya na idropathia ma ọ bụ oge adọ - 5 mcg / kg. A na-ahụ maka ọgwụ s / c otu oge ma ọ bụ ruo ọtụtụ ụbọchị, ruo mgbe ọnụọgụ nke neutrophils kwụsiri ike karịa 1500 / μl. Mgbe o mechara nsonaazụ dị mkpa iji chebe ya, a na-eji Neupomax mee ihe na mmezi nke ekpebiri iche. Mgbe izu 1-2 gachara, dabere na nzaghachi nke onye ọrịa, a na-agbakọta okpukpu abụọ ma ọ bụ ọkara.

N'ọdịnihu, otu ugboro kwa izu 1-2 ọ bụla, ọ bụrụ na ọ dị mkpa, a na-eme mgbanwe otu onye ka o wee nye gị ohere idobe ọnụọgụ nke neutrophils site na 1500 / μl ruo 10,000 / .l.

Enwere ike ịgwọ ndị ọrịa nwere ọrịa siri ike dabere na usoro na-atụ aro mmụba ngwa ngwa na dose.

Emebeghi nchekwa nke iji filgrastim ruo ogologo oge na usoro nke ihe karịrị 24 mcg / kg na ndị ọrịa nwere TCH.

Usoro ọgwụgwọ Myeloablative na-esochi site na ndọghachi azụ ma ọ bụ ụmị ọkpụkpụ

Ọgwụgwọ na-amalite site na mkpụrụ ọgwụ kwa ụbọchị nke 10 mcg / kg. A na-achịkwa Neupomax n'ụzọ intravenously n'ụdị mkpirisi nkeji iri atọ, inf 24 ma ọ bụ subcutaneous infusion.

Enwere ike ịnye ọgwụ nke mbụ tupu elekere iri abụọ na anọ awa iri ngwụcha ọgwụ gasị cytotoxic, bụrụ na ntụgharị ụmị ọkpụkpụ - agaghị erughị awa 24. Ogologo oge eji Neupomax agaghị agafe ụbọchị 28.

Enwere ike ịhazigharị kwa ụbọchị dabere na ọnụ ọgụgụ ugbu a nke neutrophils. Ọ bụrụ na maka ụbọchị 3 sochiri ọnụ ọgụgụ zuru oke nke neutrophils karịa 1000 / μl, a na-ebelata kwa ụbọchị ka ọ bụrụ 5 μg / kg, mgbe ụbọchị atọ sochirinụ mgbe ị na-eji Neupomax na usoro a ọnụọgụ zuru oke nke neutrophils agaghị adaba n'okpuru 1000 / ,l, a na-akwụsị ọgwụ ahụ. Ọ bụrụ na mbelata nke ọnụ ọgụgụ neutrophils dị n'okpuru 1000 / μl, mgbe ahụ, a na-abawanye ọnụọgụ ahụ na nke mbụ.

Nhazi nke Peripheral Blood Stem Cells (PSCC) na ndị ọrịa nwere Ọrịa Ọbara

Usoro a tụrụ aro bụ 10 mcg / kg 1 oge kwa ụbọchị dị ka ntụtụ ma ọ bụ infusion 24 na-aga n'ihu. A na-eji ọgwụ ahụ kwa ụbọchị maka ụbọchị 6. Ọzọkwa, n’ụbọchị nke ise na nke isii, a na-akpata leukapheresis. Ọ bụrụ na egosiri leukapheresis ma ọ bụ karịa, ntinye nke Neupomax na-aga n'ihu ruo na njedebe nke usoro ikpeazụ.

Ntughari nke PSCC mgbe myelosuppressive chemotherapy

A na-eme ka Neupomax na-abụ sc n'ụdị nke injections kwa ụbọchị.

Usoro a na-atụ aro kwa ụbọchị bụ 5 mcg / kg. A na-elekọta ọgwụ nke mbụ ụbọchị ngwụsị ngwụsị kemịkal, a na-aga n'ihu na ọgwụgwọ ruo mgbe a na-agụta ọnụ ọgụgụ nkịtị.

Leukapheresis ga-ekwe omume naanị mgbe ọnụọgụ nke neutrophils gafere akara nke 2000 / .l.

HIV Neutropenia

Ejiri ọgwụ a sc. Ọgwụgwọ bidoro na ubochi nke 1-4 μg / kg ma na-aga n’ihu ruo mgbe ọnụọgụ nke neutrophils na-ahazi. N'ọnọdụ ụfọdụ, enwere ike ịbawanye ọgwụ kwa ụbọchị, mana ọ bụghị ihe karịrị 10 μg / kg.

Mgbe o nwetasịrị ọgwụgwọ ọgwụgwọ, a na-ebelata oke nke Neupomax na usoro mmezi, nke na-abụkarị 300 mcg kwa ụbọchị.

N'ọdịnihu, dọkịta ahụ na-edozigharị usoro dosing n'otu n'otu maka onye ọrịa ọ bụla ka ọnụọgụ ahụ na-ejigide ọnụọgụ nke neutrophils karịa 2000 / .l.

Ime na lactation

Emebeghi nchekwa nke filgrastim n'oge eji ya n'oge afọ ime, yabụ, enwere ike ịkọ ọgwụ a naanị ma ọ bụrụ uru ele anya dị oke karịa ihe egwu dị na ya.

Enweghi ike ikike ịbanye na mmiri ara ara, yabụ, akwadoghị nhọpụta Neupomax n'oge a na-enye ya ara.

Nyocha na Neypomaks

Dika nyocha nke Neupomax, enyere ọgwụ a ọ bụghị naanị maka ọgwụ neutropenia metụtara kemoterapi, mana maka mbelata nke ọnụ ọgụgụ nke neutrophils n'ọbara n'ihi ọtụtụ ọrịa ndị ọzọ siri ike autoimmune na oncological. Ọzọkwa, iji filgrastim bụ ihe amamihe dị na nje HIV na nje ịba ọcha n'anya nke C n’ebe ndị ọrịa na-anara ọgwụ mgbochi, yana ọrịa ogbu na nkwonkwo nke ụmụaka.

N'agbanyeghị ihe ngosi ahụ, mgbe ị na-etinye Neupomax, mmụba ngwa ngwa na ọnụ ọgụgụ nke neutrophils na leukocytes, mmeghachi omume nke mkpali mere mgbe ihe dị ka ụbọchị 9 gasịrị. Ma, ndị ọrịa na-anara ọgwụ mgbochi, filgrastim kwesịrị ịdị ogologo oge.

Enwere mkpesa dị iche iche banyere mmepe nke mmetụta ndị ọzọ, dị ka akpata oyi, nkwonkwo na ọnya ọkpụkpụ, ahụ ọkụ, ọnụ na-egbu, na isi ọwụwa.

Ya mere, a na-eji Neupomax eme ihe mgbe nile ma ọ na-arụ ọrụ nke ukwuu na ọgwụgwọ na mgbochi nke neutropenia.