Analogs nke ọgwụ metglib ọgwụ

Ọgwụ ahụ nwekwara mmetụta bara uru na ngwakọta nke ọbara, na -ebelata ọkwa nke cholesterol zuru oke, obere lipoproteins dị ala (LDL) na triglycerides.

Metformin na glibenclamide nwere usoro ọrụ dị iche iche, mana jikọtara ọrụ hypoglycemic ọrụ ibe ha. Njikọ nke ndị na - arụ ọrụ hypoglycemic abụọ nwere mmetụta mmekọrịta na ibelata glucose.

Mlọ ọgwụ

Glibenclamide. Mgbe a na -ekwu ya n’onu, iwere si akwara gbasara ihe karịrị 95%. Glibenclamide, nke bụ akụkụ nke ọgwụ Glucovans® bụ micronized. Oke ruru na plasma erutela n’ihe dịka awa anọ, olu nke nkesa dị ihe dịka 10 lita. Nkwukọrịta na protein protein bụ 99%. Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju na ịmalite nke metabolites abụọ na-adịghị arụ ọrụ, nke akụrụ na-ewepụta (40%) na bile (60%). Iwepu ọkara ndụ bụ site na awa anọ ruo na iri na otu.

Metformin mgbe nchịkwa ọnụ gasịrị, ọ na-ewepụtakwa ya na eriri afọ nke zuru oke, a na-abanye n'ọtụtụ elu na plasma n'ime awa 2.5. Ihe dị ka 20-30% nke metformin na-apụ apụ site na eriri afọ na-agbanweghị. Ezigbo bioavailability sitere na 50 ruo 60%.

A na-ekesa Metformin ngwa ngwa na anụ ahụ, ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ bụ metadolized ruo obere adịghị ike ma kpụrụ ya akụrụ. Nkebi ọkara ndụ bụ ọkara 6.5. N'ihe banyere ọrụ akụrụ na-emebi emebi, mkpụchapu akwara na-adalata, dịka ikike nhichapụ nke creatinine, ebe mkpochapu ọkara ndụ na-abawanye, nke na-eduga n'ịbawanye ụba nke metformin na plasma ọbara. Nchikota nke metformin na glibenclamide n’otu usoro onodu ogwu nwere otu bioavailability dika mgbe ewere mbadamba ihe dika metformin ma obu glibenclamide n’onwe ya. Mmetụta bioavailability nke metformin yana yana glibenclamide anaghị emetụta nri oriri, yana bioavailability nke glibenclamide. Agbanyeghị, ogo oriri glibenclamide na-abawanye site na nri ị na-eri.

Ihe ngosi maka ojiji:

Diabetesdị shuga 2 n'ime ndị okenye:

Contraindications:

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.

Glucovans ® nwere lactose, yabụ akwadoghị iji ya maka ndị ọrịa nwere ọrịa hereditary ejikọtara na enweghị nkwekọrịta galactose, ụkọ lactase ma ọ bụ glucose-galactose malabsorption syndrome.

Iji nlezianya: ọrịa febrile, adrenal insufficiency, hypofunction nke isi isi, ọrịa thyroid na uncompensated mebiri nke ọrụ ya.

Jiri n’oge ime na n’oge a na-enye nwa ara
Ihe ogwu ahu n’emeghari ime. E kwesiri ịdọ onye ọrịa ahụ aka na ntị na oge ọgwụgwọ ya na Glucovans necessary ọ dị mkpa ịgwa dọkịta banyere atụmatụ ịtụrụ ime na mmalite nke ịtụrụ ime. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n’ihe gbasara afọ ime n’oge ịluụ ọgwụ Glucovans ®, ọgwụ ahụ kwesịrị ịkwụsị, yana ịnye ọgwụ insulin.

A na-enye ndị Glucovans in ara ara, n'ihi na onweghị ihe akaebe na-egosi ịbanye na mmiri ara.

Usoro onunu ogwu na nhazi

Mkpebi ọgwụ a ka dọkịta kpebiri n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ọkpụkpụ glycemia.

Ihe mbu bu 1 mbadamba ogwu Glucovans ® 2.5 mg + 500 mg ma obu Glucovans mg 5 mg + 500 mg otu ugboro kwa ubochi. Iji zere hypoglycemia, usoro mbụ ekwesịghị ịgụta kwa ụbọchị nke glibenclamide (ma ọ bụ nha nha nke ọgwụ sulfonylurea ọzọ e meburu) ma ọ bụ metformin, ma ọ bụrụ na ejiri ya mee ihe dị ka usoro ọgwụgwọ mbụ. A na-atụ aro ka ọnụọgụ ahụ rịa elu karịa 5 mg nke glibenclamide + 500 mg nke metformin kwa ụbọchị izu abụọ ma ọ bụ karịa iji nweta nchịkwa glucose ọbara zuru oke.

Ntinye ogwu eji agwughari ya na metformin na glibenclamide: dose mbụ agaghị agafe kwa ụbọchị nke glibenclamide (ma ọ bụ ihe nha nke nke ọzọ nkwadebe sulfonylurea) na metformin ewere na mbụ. Kwa izu abụọ ma ọ bụ karịa mgbe ịmalite ọgwụgwọ, a na-edozi dose ahụ dabere na ogo nke glycemia.

Oke kachasị kwa ụbọchị bụ mbadamba 4 nke ọgwụ Glucovans ® 5 mg + 500 mg ma ọ bụ mbadamba 6 nke ọgwụ Glucovans ® 2.5 mg + 500 mg.

Usoro usoro:
Usoro usoro usoro onunu ogwu dabere na ebumnuche mmadụ:

Maka onunu ogwu nke 2.5 mg + 500 mg na 5 mg + 500 mg

Maka usoro onunu ogwu nke 2.5 mg + 500 mg Ugboro atọ n'ụbọchị, n'ụtụtụ, n'ehihie na mgbede, na-enwe mbadamba 3, 5 ma ọ bụ 6 kwa ụbọchị.

Maka usoro onunu ogwu nke 5 mg + 500 mg Ugboro atọ n'ụbọchị, n'ụtụtụ, n'ehihie na mgbede, na-enwe mbadamba mbadamba 3 kwa ụbọchị.

E kwesịrị iji nri dị mbadamba. Iri nri ọ bụla nwere carbohydrate kwesịrị ịgbakwunye ya iji gbochie hypoglycemia.

Ndị okenye na-arịa ọrịa
A na-ahọrọ ọ̀gwụ nke ọgwụ ahụ dabere na steeti ọrụ arụmọrụ. Ọgwụ nke mbụ ekwesịghị ịfe 1 mbadamba ọgwụ ọgwụ Glukovans ® 2.5 mg + 500 mg. Ntụle oge niile maka ọrụ gbasara akụrụ dị mkpa.

Childrenmụaka
A naghị akwadoro Glucovans ® maka ụmụaka.

Nsonaazụ

Nsonaazụ ndị na-esote nwere ike ịme n'oge ọgwụgwọ Glucovans ®.

A na-eme atụmatụ ugboro ole mmetụta ọgwụ ahụ dị ka ndị a:
Ọtụtụ mgbe: ≥ 1/10
Ugboro: ≥ 1/100, ® kwesiri ịkwụsị. A na-atụ aro ịmaliteghachi ọgwụgwọ ka awa 48 gachara, naanị mgbe enyochala ma kọwaa ọrụ ezumike.

Ọrụ akụrụ
Ebe ọ bụ na akụrụngwa mepụtara metformin, na mgbe nke a gachara, ọ dị mkpa iji chọpụta kọwaa nke creatinine na / ma ọ bụ ihe mejupụtara ya: ọ dịkarịa ala otu ugboro n'afọ na ndị ọrịa nwere ọrụ mkpo nkịtị, yana ugboro 2-4 kwa afọ na ndị ọrịa agadi. , yana ndị ọrịa nwere ikike imebi ya site na oke nke kwesịrị.

A na-atụ aro oke nlezianya na ọnọdụ ebe enwere ike ịnwe mmekpa ahụ akụrụ, dịka ọmụmaatụ, na ndị ọrịa agadi, ma ọ bụ na mmalite nke usoro ọgwụgwọ antihypertensive, ojiji nke diuretics ma ọ bụ ọgwụ mgbochi mkpali (NSAIDs).

Prekpachara anya
Onye ọrịa ga-agwa dọkịta banyere mpụta nke ọrịa bronchopulmonary ma ọ bụ ọrịa na-efe efe nke akụkụ akụkụ ahụ.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ
Ekwesịrị ịgwa ndị ọrịa banyere ihe ize ndụ hypoglycemia ma kwesịrị ilezi anya mgbe ha na-anya ma na-arụ ọrụ na-achọkarị mmụba uche na ọsọ nke mmeghachi omume psychomotor.

Emeputa

MERC SANTE SAAS
MERCK SANTE s.a.s.

Adreesị iwu:
37 rue Saint-Romain, 69379 LION SEDEX 08, France
37 rue Saint Romain, 69379 LYON CEDEX 08, France

Adreesị saịtị:
Centre de Production SEMOIS, 2 rue du Pressoire Ver, 45400 SEMOIS, France
Centre de Production SEMOY, 2 rue du Pressoir Vert, 45400 SEMOY, France

Ekwesịrị izipu ndị na-ere ahịa na:
LLC Nycomed Distribution Center
119048 Moscow, nkp. Usacheva, nke 2, p
Adreesị ịntanetị: www.nycomed.ru

Ihe omuma a di na peeji ahu sitere n’aka dibia ogwu Vasilieva E.I.

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